A High-Confidence Human Plasma Proteome Reference Set with Estimated Concentrations in PeptideAtlas

Name: Work Video:
Duration: 3 min 30 s
Terry Farrah; Eric W. Deutsch; Gilbert S. Omenn; David Campbell; Zhi Sun; Julie Bletz; Parag Mallick; Jonathan E. Katz; Johan Malmström; Reto Ossola; Julian D. Watts; Biaoyang Lin; Hui Zhang; Robert L. Moritz; Ruedi Aebersold
{'id': 'https://openalex.org/W2142286883', 'doi': 'https://doi.org/10.1074/mcp.m110.006353', 'title': 'A High-Confidence Human Plasma Proteome Reference Set with Estimated Concentrations in PeptideAtlas', 'display_name': 'A High-Confidence Human Plasma Proteome Reference Set with Estimated Concentrations in PeptideAtlas', 'publication_year': 2011, 'publication_date': '2011-06-03', 'ids': {'openalex': 'https://openalex.org/W2142286883', 'doi': 'https://doi.org/10.1074/mcp.m110.006353', 'mag': '2142286883', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21632744', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3186192'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.m110.006353', 'pdf_url': 'http://www.mcponline.org/article/S1535947620301523/pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.mcponline.org/article/S1535947620301523/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5010025009', 'display_name': 'Terry Farrah', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3148997608', 'display_name': 'Institute for Systems Biology', 'ror': 'https://ror.org/02tpgw303', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I3148997608']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Terry Farrah', 'raw_affiliation_strings': ['Institute for Systems Biology, Seattle, WA'], 'affiliations': [{'raw_affiliation_string': 'Institute for Systems Biology, Seattle, WA', 'institution_ids': ['https://openalex.org/I3148997608']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5070102563', 'display_name': 'Eric W. Deutsch', 'orcid': 'https://orcid.org/0000-0001-8732-0928'}, 'institutions': [{'id': 'https://openalex.org/I3148997608', 'display_name': 'Institute for Systems Biology', 'ror': 'https://ror.org/02tpgw303', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I3148997608']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Eric W. Deutsch', 'raw_affiliation_strings': ['Institute for Systems Biology, Seattle, WA'], 'affiliations': [{'raw_affiliation_string': 'Institute for Systems Biology, Seattle, WA', 'institution_ids': ['https://openalex.org/I3148997608']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008478119', 'display_name': 'Gilbert S. Omenn', 'orcid': 'https://orcid.org/0000-0002-8976-6074'}, 'institutions': [{'id': 'https://openalex.org/I3148997608', 'display_name': 'Institute for Systems Biology', 'ror': 'https://ror.org/02tpgw303', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I3148997608']}, {'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gilbert S. Omenn', 'raw_affiliation_strings': ['Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI', 'Institute for Systems Biology, Seattle, WA'], 'affiliations': [{'raw_affiliation_string': 'Institute for Systems Biology, Seattle, WA', 'institution_ids': ['https://openalex.org/I3148997608']}, {'raw_affiliation_string': 'Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036793826', 'display_name': 'David Campbell', 'orcid': 'https://orcid.org/0000-0002-1740-3223'}, 'institutions': [{'id': 'https://openalex.org/I3148997608', 'display_name': 'Institute for Systems Biology', 'ror': 'https://ror.org/02tpgw303', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I3148997608']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'David S. Campbell', 'raw_affiliation_strings': ['Institute for Systems Biology, Seattle, WA'], 'affiliations': [{'raw_affiliation_string': 'Institute for Systems Biology, Seattle, WA', 'institution_ids': ['https://openalex.org/I3148997608']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080826559', 'display_name': 'Zhi Sun', 'orcid': 'https://orcid.org/0000-0003-3324-6851'}, 'institutions': [{'id': 'https://openalex.org/I3148997608', 'display_name': 'Institute for Systems Biology', 'ror': 'https://ror.org/02tpgw303', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I3148997608']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zhi Sun', 'raw_affiliation_strings': ['Institute for Systems Biology, Seattle, WA'], 'affiliations': [{'raw_affiliation_string': 'Institute for Systems Biology, Seattle, WA', 'institution_ids': ['https://openalex.org/I3148997608']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066491453', 'display_name': 'Julie Bletz', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3148997608', 'display_name': 'Institute for Systems Biology', 'ror': 'https://ror.org/02tpgw303', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I3148997608']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Julie A. Bletz', 'raw_affiliation_strings': ['Institute for Systems Biology, Seattle, WA'], 'affiliations': [{'raw_affiliation_string': 'Institute for Systems Biology, Seattle, WA', 'institution_ids': ['https://openalex.org/I3148997608']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004807599', 'display_name': 'Parag Mallick', 'orcid': 'https://orcid.org/0000-0002-0505-2032'}, 'institutions': [{'id': 'https://openalex.org/I1174212', 'display_name': 'University of Southern California', 'ror': 'https://ror.org/03taz7m60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1174212']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Parag Mallick', 'raw_affiliation_strings': ['Department of Medicine, University of Southern California, Los Angeles, CA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, University of Southern California, Los Angeles, CA', 'institution_ids': ['https://openalex.org/I1174212']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5022615394', 'display_name': 'Jonathan E. Katz', 'orcid': 'https://orcid.org/0000-0001-8175-790X'}, 'institutions': [{'id': 'https://openalex.org/I1174212', 'display_name': 'University of Southern California', 'ror': 'https://ror.org/03taz7m60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1174212']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jonathan E. Katz', 'raw_affiliation_strings': ['Department of Medicine, University of Southern California, Los Angeles, CA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, University of Southern California, Los Angeles, CA', 'institution_ids': ['https://openalex.org/I1174212']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036451897', 'display_name': 'Johan Malmström', 'orcid': 'https://orcid.org/0000-0002-2889-7169'}, 'institutions': [{'id': 'https://openalex.org/I5124864', 'display_name': 'École Polytechnique Fédérale de Lausanne', 'ror': 'https://ror.org/02s376052', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I2799323385', 'https://openalex.org/I5124864']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Johan Malmström', 'raw_affiliation_strings': ['Department of Biology, Institute of Molecular Systems Biology, ETH (Swiss Federal Institute of Technology), Zurich, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, Institute of Molecular Systems Biology, ETH (Swiss Federal Institute of Technology), Zurich, Switzerland', 'institution_ids': ['https://openalex.org/I5124864']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007559667', 'display_name': 'Reto Ossola', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I5124864', 'display_name': 'École Polytechnique Fédérale de Lausanne', 'ror': 'https://ror.org/02s376052', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I2799323385', 'https://openalex.org/I5124864']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Reto Ossola', 'raw_affiliation_strings': ['Department of Biology, Institute of Molecular Systems Biology, ETH (Swiss Federal Institute of Technology), Zurich, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, Institute of Molecular Systems Biology, ETH (Swiss Federal Institute of Technology), Zurich, Switzerland', 'institution_ids': ['https://openalex.org/I5124864']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028727045', 'display_name': 'Julian D. Watts', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I3148997608', 'display_name': 'Institute for Systems Biology', 'ror': 'https://ror.org/02tpgw303', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I3148997608']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Julian D. Watts', 'raw_affiliation_strings': ['Institute for Systems Biology, Seattle, WA'], 'affiliations': [{'raw_affiliation_string': 'Institute for Systems Biology, Seattle, WA', 'institution_ids': ['https://openalex.org/I3148997608']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048050210', 'display_name': 'Biaoyang Lin', 'orcid': 'https://orcid.org/0000-0002-2189-0407'}, 'institutions': [{'id': 'https://openalex.org/I76130692', 'display_name': 'Zhejiang University', 'ror': 'https://ror.org/00a2xv884', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I76130692']}, {'id': 'https://openalex.org/I4210093417', 'display_name': 'Swedish Medical Center', 'ror': 'https://ror.org/004jktf35', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210093417', 'https://openalex.org/I94396219']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Biaoyang Lin', 'raw_affiliation_strings': ['Swedish Neuroscience Institute, Swedish Medical Center, Seattle, WA', 'Systems Biology Division, Zhejiang-California International Nanosystems Institute (ZCNI), Zhejiang University, Hangzhou, Zhejiang, China'], 'affiliations': [{'raw_affiliation_string': 'Systems Biology Division, Zhejiang-California International Nanosystems Institute (ZCNI), Zhejiang University, Hangzhou, Zhejiang, China', 'institution_ids': ['https://openalex.org/I76130692']}, {'raw_affiliation_string': 'Swedish Neuroscience Institute, Swedish Medical Center, Seattle, WA', 'institution_ids': ['https://openalex.org/I4210093417']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100323374', 'display_name': 'Hui Zhang', 'orcid': 'https://orcid.org/0000-0001-8726-7098'}, 'institutions': [{'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Hui Zhang', 'raw_affiliation_strings': ['Department of Pathology, Johns Hopkins University, Baltimore, MD'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, Johns Hopkins University, Baltimore, MD', 'institution_ids': ['https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036737482', 'display_name': 'Robert L. Moritz', 'orcid': 'https://orcid.org/0000-0002-3216-9447'}, 'institutions': [{'id': 'https://openalex.org/I3148997608', 'display_name': 'Institute for Systems Biology', 'ror': 'https://ror.org/02tpgw303', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I3148997608']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert L. Moritz', 'raw_affiliation_strings': ['Institute for Systems Biology, Seattle, WA'], 'affiliations': [{'raw_affiliation_string': 'Institute for Systems Biology, Seattle, WA', 'institution_ids': ['https://openalex.org/I3148997608']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5053361384', 'display_name': 'Ruedi Aebersold', 'orcid': 'https://orcid.org/0000-0002-9576-3267'}, 'institutions': [{'id': 'https://openalex.org/I5124864', 'display_name': 'École Polytechnique Fédérale de Lausanne', 'ror': 'https://ror.org/02s376052', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I2799323385', 'https://openalex.org/I5124864']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Ruedi Aebersold', 'raw_affiliation_strings': ['Department of Biology, Institute of Molecular Systems Biology, ETH (Swiss Federal Institute of Technology), Zurich, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, Institute of Molecular Systems Biology, ETH (Swiss Federal Institute of Technology), Zurich, Switzerland', 'institution_ids': ['https://openalex.org/I5124864']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 7, 'corresponding_author_ids': ['https://openalex.org/A5010025009'], 'corresponding_institution_ids': ['https://openalex.org/I3148997608'], 'apc_list': {'value': 2800, 'currency': 'USD', 'value_usd': 2800, 'provenance': 'doaj'}, 'apc_paid': {'value': 2800, 'currency': 'USD', 'value_usd': 2800, 'provenance': 'doaj'}, 'fwci': 28.736, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 436, 'citation_normalized_percentile': {'value': 0.99986, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '10', 'issue': '9', 'first_page': 'M110.006353', 'last_page': 'M110.006353'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10519', 'display_name': 'Advanced Proteomics Techniques and Applications', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1607', 'display_name': 'Spectroscopy'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10519', 'display_name': 'Advanced Proteomics Techniques and Applications', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1607', 'display_name': 'Spectroscopy'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10683', 'display_name': 'Mass Spectrometry Techniques and Applications', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1607', 'display_name': 'Spectroscopy'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10836', 'display_name': 'Metabolomics and Mass Spectrometry Studies', 'score': 0.9948, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/proteome', 'display_name': 'Proteome', 'score': 0.82622284}, {'id': 'https://openalex.org/keywords/human-proteome-project', 'display_name': 'Human proteome project', 'score': 0.4941099}, {'id': 'https://openalex.org/keywords/false-discovery-rate', 'display_name': 'False Discovery Rate', 'score': 0.4179142}], 'concepts': [{'id': 'https://openalex.org/C104397665', 'wikidata': 'https://www.wikidata.org/wiki/Q860947', 'display_name': 'Proteome', 'level': 2, 'score': 0.82622284}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.5975111}, {'id': 'https://openalex.org/C46111723', 'wikidata': 'https://www.wikidata.org/wiki/Q471857', 'display_name': 'Proteomics', 'level': 3, 'score': 0.5379243}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.52902794}, {'id': 'https://openalex.org/C31827203', 'wikidata': 'https://www.wikidata.org/wiki/Q874296', 'display_name': 'Tandem mass spectrometry', 'level': 3, 'score': 0.51522595}, {'id': 'https://openalex.org/C3020134792', 'wikidata': 'https://www.wikidata.org/wiki/Q79749', 'display_name': 'Human plasma', 'level': 2, 'score': 0.50488883}, {'id': 'https://openalex.org/C94795543', 'wikidata': 'https://www.wikidata.org/wiki/Q3813754', 'display_name': 'Human proteome project', 'level': 4, 'score': 0.4941099}, {'id': 'https://openalex.org/C146543888', 'wikidata': 'https://www.wikidata.org/wiki/Q425056', 'display_name': 'Blood proteins', 'level': 2, 'score': 0.46978298}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.42472678}, {'id': 'https://openalex.org/C193244246', 'wikidata': 'https://www.wikidata.org/wiki/Q5432696', 'display_name': 'False discovery rate', 'level': 3, 'score': 0.4179142}, {'id': 'https://openalex.org/C162356407', 'wikidata': 'https://www.wikidata.org/wiki/Q180809', 'display_name': 'Mass spectrometry', 'level': 2, 'score': 0.32124603}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.2856642}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.24911761}, {'id': 'https://openalex.org/C43617362', 'wikidata': 'https://www.wikidata.org/wiki/Q170050', 'display_name': 'Chromatography', 'level': 1, 'score': 0.20065174}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.1261588}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D015415', 'descriptor_name': 'Biomarkers', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': True}, {'descriptor_ui': 'D010949', 'descriptor_name': 'Plasma', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D020543', 'descriptor_name': 'Proteome', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': True}, {'descriptor_ui': 'D040901', 'descriptor_name': 'Proteomics', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D000465', 'descriptor_name': 'Algorithms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001798', 'descriptor_name': 'Blood Proteins', 'qualifier_ui': 'Q000032', 'qualifier_name': 'analysis', 'is_major_topic': False}, {'descriptor_ui': 'D002853', 'descriptor_name': 'Chromatography, Liquid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D030562', 'descriptor_name': 'Databases, Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013058', 'descriptor_name': 'Mass Spectrometry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010455', 'descriptor_name': 'Peptides', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D012015', 'descriptor_name': 'Reference Standards', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012984', 'descriptor_name': 'Software', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014357', 'descriptor_name': 'Trypsin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.m110.006353', 'pdf_url': 'http://www.mcponline.org/article/S1535947620301523/pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3186192', 'pdf_url': 'https://europepmc.org/articles/pmc3186192?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186192', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21632744', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.m110.006353', 'pdf_url': 'http://www.mcponline.org/article/S1535947620301523/pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Partnerships for the goals', 'score': 0.41, 'id': 'https://metadata.un.org/sdg/17'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 71, 'referenced_works': ['https://openalex.org/W1512972301', 'https://openalex.org/W1572033224', 'https://openalex.org/W1759442301', 'https://openalex.org/W1969569756', 'https://openalex.org/W1971280282', 'https://openalex.org/W1974500649', 'https://openalex.org/W1977184198', 'https://openalex.org/W1982411844', 'https://openalex.org/W1985493919', 'https://openalex.org/W1985557175', 'https://openalex.org/W1987891604', 'https://openalex.org/W1995119931', 'https://openalex.org/W1997504014', 'https://openalex.org/W2002396315', 'https://openalex.org/W2002615785', 'https://openalex.org/W2013589890', 'https://openalex.org/W2015556811', 'https://openalex.org/W2027776285', 'https://openalex.org/W2029316471', 'https://openalex.org/W2030105964', 'https://openalex.org/W2036247643', 'https://openalex.org/W2043113652', 'https://openalex.org/W2043956496', 'https://openalex.org/W2044970750', 'https://openalex.org/W2046095066', 'https://openalex.org/W2046554583', 'https://openalex.org/W2049727081', 'https://openalex.org/W2051795211', 'https://openalex.org/W2052266313', 'https://openalex.org/W2057419053', 'https://openalex.org/W2065096062', 'https://openalex.org/W2073637473', 'https://openalex.org/W2075093214', 'https://openalex.org/W2081128004', 'https://openalex.org/W2084590373', 'https://openalex.org/W2085630110', 'https://openalex.org/W2087746647', 'https://openalex.org/W2093371523', 'https://openalex.org/W2102572519', 'https://openalex.org/W2104764521', 'https://openalex.org/W2112078820', 'https://openalex.org/W2114329163', 'https://openalex.org/W2117300383', 'https://openalex.org/W2122976461', 'https://openalex.org/W2123960992', 'https://openalex.org/W2128988773', 'https://openalex.org/W2129897014', 'https://openalex.org/W2130706354', 'https://openalex.org/W2132899146', 'https://openalex.org/W2138563170', 'https://openalex.org/W2139927267', 'https://openalex.org/W2142970078', 'https://openalex.org/W2144979640', 'https://openalex.org/W2146103026', 'https://openalex.org/W2148342439', 'https://openalex.org/W2148490163', 'https://openalex.org/W2148853951', 'https://openalex.org/W2150818376', 'https://openalex.org/W2153681618', 'https://openalex.org/W2155553629', 'https://openalex.org/W2157819664', 'https://openalex.org/W2160110467', 'https://openalex.org/W2161062388', 'https://openalex.org/W2172116519', 'https://openalex.org/W2188558831', 'https://openalex.org/W2202648627', 'https://openalex.org/W2415592755', 'https://openalex.org/W24553703', 'https://openalex.org/W4210430020', 'https://openalex.org/W4211000692', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W4229449181', 'https://openalex.org/W2952627046', 'https://openalex.org/W2901496258', 'https://openalex.org/W2759592955', 'https://openalex.org/W2380923603', 'https://openalex.org/W2330454676', 'https://openalex.org/W2068212194', 'https://openalex.org/W2049727081', 'https://openalex.org/W1753712793', 'https://openalex.org/W1577106742'], 'abstract_inverted_index': {'Human': [0, 237, 689, 698, 916, 984, 1592, 1615, 1721, 1784, 1916, 2061, 2484, 2639, 3037, 4187], 'blood': [1, 238, 1166, 1826], 'plasma': [2, 26, 64, 109, 239, 263, 301, 346, 475, 504, 571, 584, 611, 628, 666, 682, 714, 968, 1033, 1066, 1297, 1757, 1827, 1847, 1885, 1901, 2013, 2931, 3038, 3098, 3167], 'can': [3, 66, 148, 240, 303, 385, 514, 2222], 'be': [4, 67, 149, 241, 304, 386, 515, 673, 1760, 3759, 3786, 4110], 'obtained': [5, 242], 'relatively': [6, 243], 'noninvasively': [7, 244], 'and': [8, 51, 60, 85, 90, 245, 288, 297, 322, 327, 485, 520, 530, 576, 588, 620, 703, 709, 712, 724, 888, 900, 1074, 1133, 1255, 1322, 1427, 1439, 1460, 1508, 1536, 1631, 1660, 1743, 1771, 1864, 1925, 1941, 2022, 2268, 2345, 2351, 2393, 2414, 2447, 2464, 2528, 2591, 2608, 2661, 2850, 2862, 2940, 2944, 3046, 3122, 3134, 3158, 3168, 3220, 3240, 3262, 3297, 3299, 3394, 3409, 3430, 3625, 3712, 3775, 3800, 3875, 4023, 4258], 'contains': [9, 246, 476, 1878, 2069, 2294, 3514], 'proteins': [10, 27, 119, 247, 264, 356, 612, 741, 899, 941, 1067, 1240, 1312, 1438, 1476, 1529, 1540, 1848, 1876, 2506, 2557, 2861, 4226, 4276], 'from': [11, 73, 191, 248, 310, 428, 482, 742, 880, 962, 1313, 1419, 1531, 1710, 1766, 2290, 2366, 2482, 2748, 2842, 3144, 3150, 3160, 3165, 3315, 3441, 3518, 3823, 4203], 'most,': [12, 249], 'if': [13, 250], 'not': [14, 251, 2159, 2185, 2188, 2204, 3737], 'all,': [15, 252], 'tissues': [16, 253], 'of': [17, 25, 36, 58, 87, 99, 120, 128, 134, 165, 180, 199, 208, 224, 254, 262, 273, 295, 324, 336, 357, 365, 371, 402, 417, 436, 445, 461, 479, 496, 502, 511, 522, 540, 570, 609, 618, 636, 696, 707, 739, 873, 897, 930, 1041, 1063, 1122, 1135, 1205, 1250, 1294, 1412, 1436, 1502, 1528, 1654, 1674, 1690, 1705, 1750, 1843, 1875, 1891, 1905, 1914, 1954, 1963, 1977, 1984, 2040, 2045, 2051, 2107, 2122, 2145, 2157, 2171, 2174, 2178, 2208, 2218, 2225, 2232, 2244, 2271, 2278, 2299, 2335, 2368, 2381, 2451, 2466, 2539, 2547, 2595, 2610, 2634, 2637, 2646, 2652, 2659, 2690, 2701, 2720, 2733, 2835, 2859, 2929, 3008, 3094, 3173, 3183, 3214, 3245, 3259, 3271, 3390, 3432, 3456, 3523, 3534, 3619, 3647, 3680, 3704, 3722, 3733, 3741, 3762, 3789, 3802, 4029, 4196, 4253, 4266, 4283], 'the': [18, 34, 83, 117, 235, 255, 271, 320, 354, 472, 503, 518, 538, 542, 633, 688, 743, 874, 881, 915, 931, 1070, 1206, 1239, 1295, 1318, 1323, 1413, 1420, 1465, 1511, 1520, 1526, 1539, 1555, 1590, 1652, 1719, 1727, 1798, 1801, 1892, 1915, 1927, 2054, 2060, 2074, 2108, 2118, 2138, 2146, 2158, 2172, 2179, 2226, 2276, 2279, 2296, 2309, 2358, 2378, 2387, 2391, 2397, 2452, 2483, 2512, 2530, 2536, 2540, 2554, 2596, 2629, 2635, 2638, 2650, 2656, 2691, 2836, 2843, 2941, 3095, 3154, 3290, 3302, 3309, 3457, 3556, 3617, 3693, 3705, 3731, 3745, 3766, 3778, 4036, 4044, 4058, 4073, 4102, 4105, 4116, 4121, 4185, 4251, 4287], 'body.': [19, 256], 'Therefore,': [20, 257, 498], 'an': [21, 29, 258, 266, 493, 626, 765, 2031, 2632, 3326], 'extensive,': [22, 259], 'quantitative': [23, 260], 'catalog': [24, 261], 'is': [28, 265, 2011, 2201, 2273, 2288, 2313, 2321, 2324, 2339, 2363, 4041, 4051], 'important': [30, 267], 'starting': [31, 268], 'point': [32, 269], 'for': [33, 82, 270, 319, 517, 527, 568, 768, 787, 936, 1258, 1289, 1326, 1979, 2001, 2059, 2136, 2149, 2361, 2670, 2729, 3268, 3308, 3438, 3486, 3508, 3543, 3550, 3599, 3640, 3645, 4148, 4184, 4224, 4286], 'discovery': [35, 206, 272, 443, 654, 996, 1687, 3488, 4146], 'disease': [37, 274], 'biomarkers.': [38, 275], 'In': [39, 276, 573, 686, 1546, 1806, 4033], '2005,': [40, 277, 1547], 'we': [41, 102, 142, 175, 193, 278, 339, 379, 412, 430, 1548, 1730, 3288, 3320], 'showed': [42, 279, 1714], 'that': [43, 61, 147, 280, 298, 384, 513, 670, 1732, 1754, 2088, 2183, 2200, 2207, 2221, 2367, 2507, 3747, 3768, 4090, 4114, 4273], 'different': [44, 48, 56, 75, 132, 281, 285, 293, 312, 369, 483, 1243, 1543, 1733, 1737, 1748, 1959, 2365, 3798, 3809], 'proteomics': [45, 153, 282, 390, 769, 1570, 1734, 3398, 3572, 4151], 'measurements': [46, 98, 283, 335], 'using': [47, 168, 183, 284, 405, 420, 1479, 1736, 1929, 1945, 1968, 1995, 2412, 2937, 3555, 4263], 'sample': [49, 286, 1741, 1855, 2462, 2606, 3174], 'preparation': [50, 287, 3175], 'analysis': [52, 84, 289, 321, 501, 1169, 1572, 1744, 2417, 2450, 2594, 2928, 3040, 3241, 3574], 'techniques': [53, 169, 290, 406, 659, 1745, 3176], 'identify': [54, 291, 1746], 'significantly': [55, 292, 1747], 'sets': [57, 93, 294, 330, 669, 1080, 1630, 1749, 1937, 1953, 2044, 2753, 3292, 3307, 4153], 'proteins,': [59, 296], 'a': [62, 106, 126, 137, 145, 177, 195, 204, 218, 299, 343, 363, 374, 382, 414, 432, 441, 455, 477, 490, 499, 509, 566, 607, 615, 662, 678, 731, 735, 893, 901, 966, 1035, 1061, 1164, 1432, 1440, 1480, 1550, 1637, 1684, 1755, 1840, 1852, 1898, 1911, 1946, 1969, 1974, 1980, 2012, 2105, 2142, 2155, 2197, 2209, 2215, 2237, 2333, 2490, 2497, 2644, 2730, 2855, 2863, 3171, 3243, 3269, 3433, 3452, 3638, 3817, 4083, 4179, 4190, 4264], 'comprehensive': [63, 300, 680, 1756], 'proteome': [65, 110, 302, 347, 505, 629, 683, 969, 1758, 1886, 1902, 2014, 2927], 'compiled': [68, 105, 305, 342, 1761, 1951], 'only': [69, 306, 1462, 1762], 'by': [70, 95, 232, 307, 332, 469, 549, 614, 730, 965, 1039, 1170, 1242, 1658, 1694, 1763, 1909, 2326, 2342, 2655, 2683, 3041, 3623, 3699, 3710, 3795, 4155, 4227], 'combining': [71, 308, 1764], 'data': [72, 92, 154, 309, 329, 391, 668, 737, 895, 963, 1079, 1434, 1468, 1514, 1534, 1544, 1629, 1696, 1765, 1778, 1791, 1921, 1928, 1936, 2752, 2857, 3156, 3256, 3291, 3306, 3393, 3706, 4100, 4152], 'many': [74, 311, 535, 1767, 4034, 4062, 4078, 4278, 4314], 'experiments.': [76, 313], 'Applying': [77, 314], 'advanced': [78, 315], 'computational': [79, 316], 'methods': [80, 317, 1257], 'developed': [81, 318, 1038], 'integration': [86, 323], 'very': [88, 325, 4098, 4149], 'large': [89, 326, 1532, 3280, 4099, 4150], 'diverse': [91, 328], 'generated': [94, 331, 4154], 'tandem': [96, 228, 333, 465, 721, 4156, 4228], 'MS': [97, 229, 334, 466, 639, 722, 983, 1859], 'tryptic': [100, 337], 'peptides,': [101, 190, 338, 427, 784], 'have': [103, 211, 340, 448], 'now': [104, 341], 'high-confidence': [107, 122, 344, 359, 959, 1841], 'human': [108, 345, 583, 681, 1032, 1118, 1165, 1210, 1296, 1314, 1825, 1846, 1900, 2930, 3460], 'reference': [111, 348, 630, 684, 705, 1829, 1887, 1903, 1999, 2015, 2457, 2601], 'set': [112, 155, 198, 349, 392, 435, 738, 896, 1435, 1842, 1874, 1904, 1983, 2016, 2098, 2110, 2121, 2129, 2161, 2199, 2217, 2298, 2360, 2858, 3257, 4282], 'with': [113, 350, 623, 884, 1174, 1423, 1455, 1523, 1537, 1708, 1867, 2099, 2130, 2275, 2374, 2558, 2846, 3253, 3411, 3750, 3797, 3808, 4277], 'well': [114, 351, 525, 1725], 'over': [115, 352, 1632], 'twice': [116, 353], 'identified': [118, 187, 226, 355, 424, 463, 783, 1541, 1682, 1793, 2093, 2123, 2139, 2147, 2227, 2682, 2708, 3520, 3794, 3807, 4279, 4284], 'previous': [121, 358, 1517, 1883], 'sets.': [123, 360, 1545], 'It': [124, 361], 'includes': [125, 362, 2089, 2167, 3277, 4061], 'hierarchy': [127, 364], 'protein': [129, 181, 201, 366, 418, 438, 725, 960, 1127, 1260, 1706, 1828, 1956, 1985, 2028, 2046, 2071, 2077, 2115, 2132, 2151, 2165, 2211, 2219, 2234, 2240, 2251, 2282, 2319, 2372, 2409, 2498, 2706, 3819, 3873, 4039, 4070, 4088, 4122, 4182], 'identifications': [130, 367, 961, 1656, 1957, 2047, 3621, 3682, 3728, 3754], 'at': [131, 203, 368, 440, 1683, 1958, 2030, 2048, 2065, 2090, 2545, 2628, 4104, 4115, 4120], 'levels': [133, 370, 1962, 2050], 'redundancy': [135, 372, 1964, 2052], 'following': [136, 373, 2932], 'clearly': [138, 375, 1960], 'defined': [139, 376, 1961], 'scheme,': [140, 377], 'which': [141, 192, 378, 429, 727, 1503, 2041, 2112, 2137, 2163, 2284, 3524, 4270], 'propose': [143, 380], 'as': [144, 171, 381, 408, 508, 524, 526, 1692, 1724, 1726, 1775, 1779, 1993, 2643, 2649, 2695, 3590], 'standard': [146, 383, 2537], 'applied': [150, 387, 1325, 3691, 4208], 'to': [151, 156, 161, 388, 393, 398, 532, 672, 676, 715, 1310, 1464, 1506, 1510, 1588, 1650, 1699, 1773, 1896, 1939, 1987, 2206, 2283, 2306, 2384, 2396, 2535, 3322, 3334, 3397, 3615, 3692, 3696, 3758, 3777, 3785, 3816, 4068, 4086, 4109, 4177, 4199, 4205, 4209, 4247, 4275, 4312], 'any': [152, 389, 1882, 2070, 2175], 'facilitate': [157, 394], 'cross-proteome': [158, 395], 'analyses.': [159, 396], 'Further,': [160, 397], 'aid': [162, 399], 'in': [163, 227, 400, 464, 661, 665, 957, 1004, 1069, 1075, 1232, 1238, 1477, 1542, 1800, 1923, 2073, 2236, 2242, 2266, 2308, 2390, 2500, 2561, 2696, 2933, 3119, 3123, 3491, 3495, 3592, 3683, 3772, 3879, 4043, 4053, 4077, 4082, 4175], 'development': [164, 401], 'blood-based': [166, 403, 1989], 'diagnostics': [167, 404], 'such': [170, 407, 1777, 1992], 'selected': [172, 409, 1000, 2002, 3314], 'reaction': [173, 410, 657, 1001, 2003], 'monitoring,': [174, 411], 'provide': [176, 413], 'rough': [178, 415, 1975], 'estimate': [179, 416, 1651, 1976, 2633, 3616], 'concentrations': [182, 419, 1978, 2410, 2560], 'spectral': [184, 421, 1970, 2480, 3329, 3434, 3453, 3461, 3484, 3492], 'counting.': [185, 422], 'We': [186, 210, 423, 447, 1752, 1933, 2744], '20,433': [188, 425], 'distinct': [189, 426, 1137, 1702, 1795, 2734, 4249], 'inferred': [194, 431, 1530], 'highly': [196, 433, 1872, 1981, 2026], 'nonredundant': [197, 434, 1036, 1065, 1873, 1982, 2027], '1929': [200, 437, 2025], 'sequences': [202, 439, 1986, 2029, 2116, 2133, 2182, 2220, 2235, 2348, 2373, 2382, 2707, 4071, 4089], 'false': [205, 442, 995, 1246, 1686, 3487, 4145], 'rate': [207, 444, 997, 1688, 3489], '1%.': [209, 446], 'made': [212, 449, 1657, 3622], 'this': [213, 450, 4080], 'resource': [214, 451], 'available': [215, 452], 'via': [216, 453], 'PeptideAtlas,': [217, 454, 1723, 2487, 4189], 'large,': [219, 456], 'multiorganism,': [220, 457], 'publicly': [221, 458], 'accessible': [222, 459], 'compendium': [223, 460], 'peptides': [225, 462, 1680, 2000, 2140, 2148, 2173, 2263, 2331, 2389, 3646, 3793, 3806, 4268, 4272, 4285], 'experiments': [230, 467, 1735, 2006, 3281, 3318, 3764, 3774], 'conducted': [231, 468], 'laboratories': [233, 470, 719, 887, 1426, 2849], 'around': [234, 471], 'world.': [236, 473], 'Blood': [474], 'combination': [478, 1040], 'subproteomes': [480], 'derived': [481, 3517, 3822], 'tissues,': [484], 'thus,': [486], 'it': [487, 2285, 2293, 2338, 4050], 'potentially': [488], 'provides': [489], 'window': [491], 'into': [492, 734, 3293], "individual's": [494], 'state': [495], 'health.': [497], 'detailed': [500], 'holds': [506], 'promise': [507], 'source': [510], 'biomarkers': [512], 'used': [516, 643, 1321, 1549], 'diagnosis': [519], 'staging': [521], 'diseases,': [523], 'monitoring': [528, 2004], 'progression': [529], 'response': [531], 'therapy.': [533], 'For': [534, 3286, 4097], 'years,': [536], 'before': [537], 'era': [539], 'proteomics,': [541], 'classic': [543], 'multivolume': [544], 'reference,': [545], 'The': [546, 555, 582, 761, 1031, 1117, 1781, 1889, 2009, 2370, 2524, 2551, 2626, 3304, 3547, 3717, 3871, 4281], 'Plasma': [547, 556, 699, 876, 917, 987, 1415, 1593, 1616, 1722, 1785, 1917, 2062, 2454, 2485, 2598, 2640, 2838, 4188], 'Proteins': [548, 3216], 'Frank': [550], 'Putnam': [551], '(1975–1989)': [552], '(1Putnam': [553], 'F.W.': [554], 'Proteins.': [557], '2nd': [558], 'Ed.': [559], 'Academic': [560], 'Press,': [561], 'New': [562, 920], 'York1975–1989Google': [563], 'Scholar),': [564, 1501, 1625, 3589, 3890, 4022], 'provided': [565, 704, 1973], 'foundation': [567], 'studies': [569, 1711], 'proteins.': [572, 1703, 1751, 1805], '2002,': [574, 687], 'Anderson': [575, 577, 580, 1006, 1111, 2899, 2905, 2996], '(2Anderson': [578], 'N.L.': [579, 1010, 1112, 1602], 'N.G.': [581], 'proteome:': [585, 1034, 1120, 1168], 'history,': [586], 'character,': [587], 'diagnostic': [589, 1990], 'prospects.Mol.': [590], 'Cell': [591, 1045, 1177, 1213, 2948, 3100, 3687, 4159], 'Proteomics.': [592, 1046, 1178, 1214, 1494, 2883, 2949, 3101, 3226, 4160, 4302], '2002;': [593, 1179, 1664, 3629], '1:': [594, 1180, 1496, 1834, 2885, 4304], '845-867Abstract': [595], 'Full': [596, 598, 1050, 1052, 1182, 1184, 1218, 1220, 2953, 2955, 3105, 3107, 3230, 3232, 4164, 4166], 'Text': [597, 599, 1051, 1053, 1183, 1185, 1219, 1221, 2954, 2956, 3106, 3108, 3231, 3233, 4165, 4167], 'PDF': [600, 1054, 1186, 1222, 2957, 3109, 3234, 4168], 'PubMed': [601, 774, 907, 976, 1055, 1142, 1187, 1223, 1303, 1446, 1583, 1621, 1667, 1836, 2473, 2617, 2869, 2958, 3017, 3054, 3110, 3235, 3404, 3446, 3502, 3585, 3632, 3886, 4018, 4169, 4235], 'Scopus': [602, 775, 908, 923, 977, 1056, 1143, 1188, 1224, 1304, 1447, 1498, 1584, 1622, 1668, 2474, 2618, 2870, 2887, 2959, 3018, 3055, 3111, 3236, 3405, 3447, 3503, 3586, 3633, 3887, 4019, 4170, 4236, 4306], '(3528)': [603], 'Google': [604, 777, 910, 925, 979, 1058, 1145, 1190, 1226, 1306, 1449, 1500, 1586, 1624, 1670, 1837, 2476, 2620, 2872, 2889, 2961, 3020, 3057, 3113, 3132, 3238, 3407, 3449, 3505, 3588, 3635, 3845, 3889, 4021, 4172, 4238, 4308], 'Scholar)': [605, 778, 1059, 1307, 1450, 1587, 1671, 1838, 2477, 2621, 3133, 3408, 3450, 3472, 3506, 3636, 3689, 4239, 4309], 'published': [606, 1060, 1077, 1839], 'review': [608, 1073], '289': [610], 'studied': [613], 'wide': [616], 'variety': [617, 3172, 3244], 'methods,': [619, 1244], 'quantified': [621], 'primarily': [622], 'immunoassays,': [624], 'providing': [625], 'early': [627], 'set.': [631, 685, 1469, 1515, 1888, 2180], 'Subsequently,': [632], 'widespread': [634], 'adoption': [635], 'liquid': [637, 981], 'chromatography-tandem': [638, 645, 982], '(LC-MS/MS)': [640], '1The': [641], 'abbreviations': [642], 'are:LC-MS/MSliquid': [644], 'MSHUPOHuman': [646], 'Proteome': [647, 649, 690, 700, 877, 985, 988, 1416, 2455, 2599, 2839, 3012, 3049, 3117, 3497], 'OrganizationPPPPlasma': [648], 'ProjectIPIInternational': [650], 'Protein': [651, 745, 763, 991, 2181, 2347, 4143], 'IndexTPPTrans-Proteomic': [652], 'PipelineFDRfalse': [653], 'ratePSMpeptide-spectrum': [655], 'matchSRMselected': [656], 'monitoring.': [658, 1002], 'resulted': [660, 4081], 'rapid': [663], 'increase': [664], 'proteome-related': [667], 'needed': [671], 'similarly': [674], 'integrated': [675, 729, 766], 'form': [677, 2141, 2332], 'next-generation': [679], 'Organization': [691, 986], '(HUPO)': [692], 'launched': [693], 'Phase': [694, 3145, 3152], 'I': [695, 3146], 'its': [697, 2317, 2329, 3395, 3876, 4254], 'Project': [701, 989, 2456, 2600], '(PPP)': [702], 'specimens': [706], 'serum': [708, 1119, 1167, 1211, 1478, 3009, 3169], 'EDTA-,': [710], 'citrate-,': [711], 'heparin-anticoagulated': [713], '55': [716], 'laboratories.': [717, 3163], 'Eighteen': [718], 'contributed': [720], 'findings': [723], 'identifications,': [726], 'were': [728, 1230, 1681, 2508, 3247, 3251, 3312, 3332, 3553], 'collaborative': [732, 970], 'process': [733], 'core': [736, 894, 1433, 1467, 1513, 2856], '3020': [740, 898, 1437, 2860], 'International': [744, 762, 990], 'Index': [746, 992], '(IPI)': [747], 'database': [748, 767, 1661, 2079, 3626, 3821, 4046, 4060], '(3Kersey': [749], 'P.J.': [750], 'Duarte': [751], 'J.': [752, 825, 839, 841, 951, 1106, 1114, 1364, 1378, 1380, 1561, 2787, 2801, 2803, 2999, 3563, 3922, 3982, 4000, 4006], 'Williams': [753], 'A.': [754, 821, 855, 857, 861, 1030, 1360, 1394, 1396, 1400, 1559, 1640, 2369, 2433, 2577, 2783, 2817, 2819, 2823, 3070, 3561, 3605, 3673, 3838, 3850, 3856, 3936, 3940, 3962, 3980, 3988, 4002, 4136, 4216], 'Karavidopoulou': [755], 'Y.': [756, 1266, 2902, 3910], 'Birney': [757, 3989], 'E.': [758, 1644, 3351, 3367, 3609, 3830, 3858, 3906, 3950, 3990, 4218], 'Apweiler': [759, 804, 1343, 2766, 3354, 3851], 'R.': [760, 801, 805, 823, 845, 853, 1014, 1028, 1082, 1110, 1273, 1340, 1344, 1362, 1384, 1392, 1567, 1612, 1614, 1646, 2429, 2573, 2763, 2767, 2785, 2807, 2815, 2908, 2970, 3209, 3341, 3355, 3377, 3379, 3385, 3428, 3481, 3569, 3611, 3668, 3852, 3932, 3946, 3996, 4142, 4220], 'Index:': [764], 'experiments.Proteomics.': [770], '2004;': [771, 1047, 1300, 1495, 2884, 3401, 4303], '4:': [772, 2951, 3052, 3228], '1985-1988Crossref': [773], '(640)': [776], 'containing': [779, 1626, 2024, 4072], 'two': [780, 1857, 2114, 3278, 3294], 'or': [781, 2518, 3650, 3726, 4095], 'more': [782, 1920, 1930, 2168, 3756, 3783], 'plus': [785, 3473], 'filters': [786], 'smaller,': [788], 'higher': [789], 'confidence': [790, 1908], 'lists': [791], '(4Omenn': [792, 1331], 'G.S.': [793, 945, 1332, 2445, 2589, 2755], 'States': [794, 1333, 2756], 'D.J.': [795, 943, 1334, 2757, 2906], 'Adamski': [796, 1335, 2758], 'M.': [797, 863, 1012, 1102, 1336, 1402, 1819, 2435, 2579, 2759, 2825, 2984, 3343, 3834, 3836, 3870, 3930, 3968, 4130, 4134], 'Blackwell': [798, 946, 1337, 2760], 'T.W.': [799, 947, 1338, 2761], 'Menon': [800, 1339, 2762], 'Hermjakob': [802, 1341, 2764, 3360], 'H.': [803, 831, 867, 1342, 1370, 1406, 1600, 1608, 2765, 2793, 2829, 2966, 2988, 3190, 3361, 3416, 3477], 'Haab': [806, 1345, 2768], 'B.B.': [807, 1346, 2419, 2563, 2769], 'Simpson': [808, 1347, 2770, 3376], 'R.J.': [809, 1154, 1275, 1348, 2771, 2904, 3034, 3076], 'Eddes': [810, 1349, 2772, 3419], 'J.S.': [811, 835, 1350, 1374, 2773, 2797, 3420], 'Kapp': [812, 1351, 2774, 3366], 'E.A.': [813, 1352, 2775, 3116], 'Moritz': [814, 1353, 2776], 'R.L.': [815, 1354, 2777], 'Chan': [816, 1194, 1355, 1470, 2778, 3155], 'D.W.': [817, 869, 953, 1356, 1408, 2779, 2831], 'Rai': [818, 1357, 2780], 'A.J.': [819, 1086, 1358, 2781], 'Admon': [820, 1359, 2782], 'Aebersold': [822, 1361, 1566, 1613, 1645, 2784, 3208, 3384, 3427, 3480, 3568, 3610, 4141, 4219], 'Eng': [824, 950, 1363, 1560, 1597, 2786, 2967, 3338, 3421, 3562], 'Hancock': [826, 1365, 2788], 'W.S.': [827, 1366, 2789], 'Hefta': [828, 1367, 2790], 'S.A.': [829, 1368, 2791], 'Meyer': [830, 1369, 2792], 'Paik': [832, 1371, 2794], 'Y.K.': [833, 1372, 2795], 'Yoo': [834, 1373, 2796], 'Ping': [836, 1375, 2798], 'P.': [837, 865, 1376, 1404, 2431, 2575, 2799, 2827, 3196, 3912, 3958, 4010], 'Pounds': [838, 1025, 1161, 1377, 2800], 'Adkins': [840, 1023, 1379, 2442, 2586, 2802], 'Qian': [842, 1381, 2804, 3024, 3061], 'X.': [843, 851, 1382, 1390, 2805, 2813], 'Wang': [844, 1107, 1383, 2806], 'Wasinger': [846, 1385, 2808], 'V.': [847, 1386, 2809, 3994], 'Wu': [848, 1387, 2810], 'C.Y.': [849, 1388, 2811], 'Zhao': [850, 1101, 1389, 2812], 'Zeng': [852, 1391, 2814], 'Archakov': [854, 1393, 2816], 'Tsugita': [856, 1395, 2818], 'Beer': [858, 1397, 2820], 'I.': [859, 1398, 2821, 3866, 3954], 'Pandey': [860, 1399, 2822], 'Pisano': [862, 1401, 2824], 'Andrews': [864, 1403, 2826], 'Tammen': [866, 1405, 2828], 'Speicher': [868, 952, 1407, 2830], 'Hanash': [870, 954, 1409, 2832], 'S.M.': [871, 955, 1150, 1410, 2833, 3074], 'Overview': [872, 1411, 2834], 'HUPO': [875, 967, 1414, 1456, 2453, 2597, 2837], 'Project:': [878, 1417, 2840], 'results': [879, 1418, 2841, 3549, 3695], 'pilot': [882, 1421, 2844], 'phase': [883, 1422, 2845], '35': [885, 1424, 2847], 'collaborating': [886, 1425, 2848], 'multiple': [889, 937, 1428, 2851, 3734, 3751, 3773, 4047, 4054, 4087], 'analytical': [890, 1429, 2852], 'groups,': [891, 1430, 2853, 3295], 'generating': [892, 1431, 2854], 'publicly-available': [902, 1441, 2864], 'database.Proteomics.': [903, 1442, 2865], '2005;': [904, 1443, 1581, 1618, 2470, 2614, 2866, 2950, 3051, 3227, 3583], '5:': [905, 1444, 1619, 2471, 2615, 2867, 3103, 3130], '3226-3245Crossref': [906, 1445, 2868], '(687)': [909, 1448, 2871], 'Scholar,': [911, 1146, 1191, 2873, 2890, 2962, 3021, 3058, 3114, 3846], '5Omenn': [912], 'G.': [913, 1817, 2423, 2441, 2567, 2585, 3373, 3916, 3970, 3976, 4004], 'Exploring': [914], 'Proteome.': [918], 'Wiley-VCH,': [919], 'York,': [921], 'NY2006Crossref': [922], '(0)': [924], 'Scholar).': [926, 980, 1227, 4032, 4173], 'A': [927, 1568, 1820, 2291, 2312, 2327, 3386, 3530, 3570, 4221], 'stringent': [928, 1252, 1868, 1931, 4191], 're-analysis': [929], 'PPP': [932, 3147, 3151], 'data,': [933], 'including': [934, 3142, 3826], 'adjustment': [935], 'comparisons,': [938], 'yielded': [939], '889': [940], '(6States': [942], 'Omenn': [944, 1328, 2444, 2588, 3372], 'Fermin': [948], 'D.': [949, 1490, 2346, 2879, 3832, 3942, 3952, 3966, 3972, 4298], 'Challenges': [956], 'deriving': [958], 'gathered': [964], 'study.Nat.': [971], 'Biotechnol.': [972, 3400], '2006;': [973, 3102], '24:': [974], '333-338Crossref': [975], '(286)': [978], 'Trans-Proteomic': [993, 1556, 3557], 'Pipeline': [994, 1557, 3558], 'peptide-spectrum': [998, 3642], 'match': [999, 3643], 'Meanwhile,': [1003], '2004,': [1005], 'et': [1007, 1263, 1329, 1471, 1491, 1809, 2880, 4299], 'al.': [1008, 1264, 1330, 1472, 1810], '(7Anderson': [1009], 'Polanski': [1011], 'Pieper': [1013], 'Gatlin': [1015, 1083], 'T.': [1016, 2896, 2982, 2992, 3023, 3060], 'Tirumalai': [1017], 'R.S.': [1018, 1193], 'Conrads': [1019, 1200], 'T.P.': [1020, 1201], 'Veenstra': [1021, 1202], 'T.D.': [1022, 1203, 2976], 'J.N.': [1024, 1148, 2443, 2587], 'J.G.': [1026, 1162], 'Fagan': [1027], 'Lobley': [1029], 'list': [1037], 'four': [1042, 1234, 2521], 'separate': [1043], 'sources.Mol.': [1044], '3:': [1048, 1140], '311-326Abstract': [1049], '(749)': [1057], 'compilation': [1062], '1175': [1064], 'reported': [1068, 1231, 1308, 1473, 2559], '2002': [1071], 'literature': [1072], 'three': [1076, 2371], 'experimental': [1078], '(8Pieper': [1081], 'C.L.': [1084], 'Makusky': [1085], 'Russo': [1087], 'P.S.': [1088], 'Schatz': [1089], 'C.R.': [1090], 'Miller': [1091], 'S.S.': [1092], 'Su': [1093], 'Q.': [1094], 'McGrath': [1095], 'A.M.': [1096], 'Estock': [1097], 'M.A.': [1098, 3027, 3064], 'Parmar': [1099], 'P.P.': [1100], 'Huang': [1103, 3362], 'S.T.': [1104], 'Zhou': [1105], 'F.': [1108, 2425, 2569, 3948, 3992], 'Esquer-Blasco': [1109], 'Taylor': [1113, 3380], 'Steiner': [1115], 'S.': [1116, 1812, 2427, 2439, 2571, 2583, 3363, 3868, 3900, 3908, 3918, 3920, 3926, 3928, 3944, 3978, 3984, 3986, 4008], 'display': [1121], 'nearly': [1123], '3700': [1124], 'chromatographically': [1125], 'separated': [1126, 3289], 'spots': [1128], 'on': [1129, 1317, 1554, 1850, 1856, 2489, 2553, 3242, 3730, 4243], 'two-dimensional': [1130], 'electrophoresis': [1131], 'gels': [1132], 'identification': [1134, 1253, 3440, 4144], '325': [1136], 'proteins.Proteomics.': [1138], '2003;': [1139, 1215, 3129, 3883, 4232], '1345-1364Crossref': [1141], '(462)': [1144], '9Adkins': [1147], 'Varnum': [1149, 3073], 'Auberry': [1151], 'K.J.': [1152], 'Moore': [1153, 1274, 2903, 3033, 3075], 'Angell': [1155], 'N.H.': [1156], 'Smith': [1157, 1276, 2924, 3000, 3035, 3088, 3204, 3378, 4005], 'R.D.': [1158, 1277, 2925, 3001, 3036, 3089, 3205], 'Springer': [1159], 'D.L.': [1160], 'Toward': [1163], 'multidimensional': [1171, 1481], 'separation': [1172, 1483], 'coupled': [1173], 'mass': [1175, 2467, 2611, 2943, 3047, 3391, 3532, 3810, 4157, 4229], 'spectrometry.Mol.': [1176, 4158], '947-955Abstract': [1181], '(713)': [1189], '10Tirumalai': [1192], 'K.C.': [1195, 1486, 2875, 4294], 'Prieto': [1196], 'D.A.': [1197, 1488, 2877, 4296], 'Issaq': [1198], 'H.J.': [1199], 'Characterization': [1204], 'low': [1207], 'molecular': [1208], 'weight': [1209], 'proteome.Mol.': [1212, 3099], '2:': [1216], '1096-1103Abstract': [1217], '(727)': [1225], 'Only': [1228], '46': [1229], 'all': [1233, 2224, 2386, 3313, 4069], 'sources,': [1235], 'suggesting': [1236], 'variability': [1237], 'detected': [1241], 'high': [1245, 1290, 1821, 1907, 3752], 'positive': [1247], 'rates': [1248, 4147], 'because': [1249, 2194, 2292, 2316, 2328, 2357, 3319, 4049, 4057], 'insufficiently': [1251], 'criteria,': [1254], 'nonuniform': [1256], 'assigning': [1259, 4246], 'identifications.': [1261], 'Shen': [1262, 2901], '(11Shen': [1265], 'Jacobs': [1267, 2897], 'J.M.': [1268, 2898, 4138], 'Camp': [1269, 2921, 2993, 3028, 3085, 3201], '2nd,': [1270, 2922, 2994, 3029, 3086], 'D.G.': [1271, 2923, 2995, 3030, 3087, 3203], 'Fang': [1272, 2969], 'Xiao': [1278, 2913, 3065], 'W.': [1279, 2914, 3066, 3383, 3974], 'Davis': [1280, 2917, 3081], 'R.W.': [1281, 2918, 3082], 'Tompkins': [1282, 2919, 3083], 'R.G.': [1283, 2920, 3084], 'Ultra-high-efficiency': [1284], 'strong': [1285], 'cation': [1286], 'exchange': [1287], 'LC/RPLC/MS/MS': [1288], 'dynamic': [1291, 3091], 'range': [1292, 3092], 'characterization': [1293, 3093], 'proteome.Anal.': [1298], 'Chem.': [1299, 1663, 3628, 4231], '76:': [1301], '1134-1144Crossref': [1302], '(282)': [1305], '800': [1309], '1682': [1311], 'plasma,': [1315], 'depending': [1316], 'proteolytic': [1319], 'enzymes': [1320], 'criteria': [1324], 'identification;': [1327], 're-analyzed': [1451], 'those': [1452, 1709, 3708], 'raw': [1453, 1935, 2746], 'spectra': [1454, 2747, 3516, 3743], 'PPP-I': [1457, 1466, 1512, 1728], 'search': [1458, 3323, 3548, 3735], 'parameters': [1459, 3601], 'matched': [1461, 3776], '213': [1463], '1444': [1474], 'unique': [1475], 'peptide': [1482, 1655, 1685, 1943, 2198, 2359, 3439, 3620, 3681, 3714, 3780, 4075, 4106, 4250], 'strategy': [1484], '(12Chan': [1485, 4293], 'Lucas': [1487, 2876, 4295], 'Hise': [1489, 2878, 4297], 'al.Serum/Plasma': [1492, 2881, 4300], 'Proteome.Clinical': [1493, 2882, 4301], '101-225Crossref': [1497, 2886, 4305], '(104)': [1499, 2888, 4307], '1019': [1504], 'mapped': [1505, 3813, 4067], 'IPI': [1507, 2083, 3891], '257': [1509], 'These': [1516], 'efforts': [1518, 1991], 'highlight': [1519], 'challenges': [1521], 'associated': [1522], 'accurately': [1524], 'determining': [1525], 'number': [1527, 1799, 2651, 2658, 3721, 3740, 3761, 3788, 3801, 4265], 'proteomic': [1533], 'sets,': [1535, 1792, 4101], 'comparing': [1538], 'uniform': [1551, 1569, 1947, 3571], 'method': [1552, 3437], 'based': [1553, 1849, 3729], '(13Keller': [1558, 3560], 'Zhang': [1562, 1599, 2907, 2965, 2987, 3564], 'N.': [1563, 3424, 3565, 3938], 'Li': [1564, 3193, 3566], 'X.J.': [1565, 3194, 3567], 'MS/MS': [1571, 1659, 3573, 3624], 'platform': [1573, 3575], 'utilizing': [1574, 3576], 'open': [1575, 3388, 3577], 'XML': [1576, 3578], 'file': [1577, 3579], 'formats.Mol.': [1578, 3580], 'Syst.': [1579, 3581], 'Biol.': [1580, 3582, 3841], '12005.0017Crossref': [1582, 3584], '(595)': [1585, 3587], 'create': [1589], 'first': [1591], 'PeptideAtlas': [1594, 1786, 1918, 1940, 2642], '(14Deutsch': [1595], 'E.W.': [1596, 3345, 3418, 3479], 'J.K.': [1598, 2968, 3339, 3422], 'King': [1601, 3423], 'Nesvizhskii': [1603, 1641, 3606], 'A.I.': [1604, 1642, 3607, 4214], 'Lin': [1605, 2985], 'B.': [1606, 3347, 3349, 3848, 3902, 3960, 3964], 'Lee': [1607], 'Yi': [1609, 3191], 'E.C.': [1610, 3192], 'Ossola': [1611], 'PeptideAtlas.Proteomics.': [1617], '3497-3500Crossref': [1620], '(123)': [1623], '28': [1627], 'LC-MS/MS': [1628, 1790, 2751, 3264, 3273], '1.9': [1633], 'million': [1634], 'spectra.': [1635], 'Using': [1636, 3217], 'PeptideProphet': [1638, 3603, 3694], '(15Keller': [1639, 3604], 'Kolker': [1643, 3608, 4217], 'Empirical': [1647, 3612], 'statistical': [1648, 3613, 3678, 4222], 'model': [1649, 3614, 4223], 'accuracy': [1653, 3618], 'search.Anal.': [1662, 3627], '74:': [1665, 3630], '5383-5392Crossref': [1666, 3631], '(3857)': [1669, 3634], 'probability': [1672, 2281, 3639, 3753, 4200, 4252, 4256], 'threshold': [1673], 'p': [1675], '>': [1676], '=': [1677, 2704, 2716, 2722], '0.90,': [1678], '6929': [1679], '(FDR)': [1689], '12%,': [1691], 'estimated': [1693, 2032], "PeptideProphet's": [1695], 'model,': [1697, 4269], 'mapping': [1698, 4085], 'about': [1700], '960': [1701], 'Comparison': [1704], 'identifiers': [1707], 'cited': [1712], 'above': [1713, 2527], 'quite': [1715], 'limited': [1716], 'overlap.': [1717], 'From': [1718], '2005': [1720, 1802], 'collaboration,': [1729], 'concluded': [1731], 'samples,': [1738, 3170], 'depletion,': [1739, 1862], 'fractionation,': [1740], 'preparation,': [1742], 'decided': [1753], 'could': [1759], 'diverse,': [1768], 'high-quality': [1769, 2750], 'experiments,': [1770, 2693, 3148], 'strove': [1772], 'collect': [1774], 'much': [1776, 4111, 4124], 'possible.': [1780], 'resulting': [1782], '2007': [1783, 1924], '(unpublished),': [1787], 'encompassing': [1788], '53': [1789], '27,801': [1794], 'peptides—four': [1796], 'times': [1797, 4048], 'Atlas—and': [1803], '2738': [1804], '2008,': [1807], 'Schenk': [1808], '(16Schenk': [1811], 'Schoenhals': [1813], 'G.J.': [1814], 'de': [1815], 'Souza': [1816], 'Mann': [1818], 'confidence,': [1822], 'manually': [1823], 'validated': [1824], 'set.BMC': [1830], 'Med.': [1831, 3128], 'Genomics.': [1832], '2008;': [1833], '41Crossref': [1835], '697': [1844], 'nonimmunoglobulin': [1845], 'measuring': [1851], 'single': [1853], 'pooled': [1854], 'high-end': [1858], 'instruments': [1860, 3246], 'after': [1861], 'prefractionation,': [1863], 'protease': [1865, 3184], 'inhibition,': [1866], 'validation': [1869, 1944, 3431, 3679], 'methods.': [1870], 'This': [1871, 3512], 'likely': [1877, 2305, 3757, 3784], 'fewer': [1879, 2519], 'false-positives': [1880], 'than': [1881, 1922, 2169, 2520, 4113], 'MS-derived': [1884], 'goal': [1890], 'present': [1893], 'work': [1894], 'was': [1895, 3538, 3690, 4066, 4207, 4240, 4310], 'compile': [1897], 'larger': [1899, 4112, 4125], 'similar': [1906, 2731], 'creating': [1910], 'new': [1912], 'release': [1913], 'incorporating': [1919], 'interpreting': [1926], 'criteria.': [1932], 'searched': [1934, 3410], 'submitted': [1938], 'performed': [1942], 'pipeline': [1948], '(Fig.': [1949, 1965, 2007, 2017], '1),': [1950], 'several': [1952, 3135, 3159], 'corresponding': [1955], '2),': [1966], 'and,': [1967, 4119], 'counting': [1971], 'technique,': [1972], 'guide': [1988], 'doping': [1994], 'stable': [1996], 'isotope-labeled': [1997], 'synthetic': [1998], '(SRM)': [2005], '3).': [2008], 'result': [2010], '4)': [2018], '(supplemental': [2019], 'Tables': [2020], 'S3': [2021], 'S6)': [2023], '1%': [2033, 4180], 'FDR.Fig.': [2034], '2A,': [2035], 'Six': [2036], 'shaded': [2037], 'bars': [2038], '(two': [2039], 'overlap)': [2042], 'represent': [2043, 2250, 2258, 2505, 2556], 'various': [2049, 3179], 'under': [2053], 'Cedar': [2055], 'scheme.': [2056], 'Tallies': [2057], 'are': [2058, 2184, 2190, 2264, 2303, 2353, 2533, 3720, 3755, 3782, 4091], 'PeptideAtlas.': [2063], 'Beginning': [2064], 'bottom:': [2066], '•Exhaustive': [2067], 'set:': [2068, 2096, 2104, 2127, 2154, 2214], 'sequence': [2072, 2078, 2166, 3781, 3820, 4040], "atlas'": [2075], 'combined': [2076, 3301, 3818, 4045], '(Swiss-Prot': [2080], '2010–04': [2081, 3825], '+': [2082, 2085, 2714], 'v3.71': [2084], 'Ensembl': [2086, 3893, 4011, 4059], 'v57.37)': [2087], 'least': [2091], 'one': [2092, 2269, 2689, 3261, 3474], 'peptide.': [2094], '•Sequence-unique': [2095], 'exhaustive': [2097], 'exact': [2100, 2119, 4037], 'duplicates': [2101], 'removed.': [2102], '•Peptide-set-unique': [2103], 'subset': [2106, 2144, 2156, 2334, 2380], 'sequence-unique': [2109], 'within': [2111, 2162, 2663], 'no': [2113, 2164, 2623], 'include': [2117, 3525], 'same': [2120, 2297, 3779, 4038], 'peptides.': [2124, 2228, 2260, 4280], '•Not': [2125], 'subsumed': [2126, 2131, 2160, 2325, 2341], 'peptide-set-unique': [2128], 'removed': [2134], '(those': [2135], 'proper': [2143], 'another': [2150], 'sequence).': [2152], '•Canonical': [2153], '80%': [2170], 'other': [2176], 'member': [2177], 'subsumed,': [2186], 'but': [2187, 2203, 2311, 2622], 'canonical': [2189, 2210, 2315, 2705], 'called': [2191], 'possibly': [2192, 2355], 'distinguished,': [2193], 'each': [2195, 2272, 2362, 2664, 2684, 3509, 3551, 3641, 3814, 4210, 4244, 4248], 'has': [2196], 'close,': [2202], 'identical,': [2205], 'sequence.': [2212], '•Covering': [2213], 'minimal': [2216], 'explain': [2223, 2385], 'B,': [2229, 2349], 'Peptide-centric': [2230], 'illustration': [2231], 'six': [2233], 'hypothetical': [2238], 'ProteinProphet': [2239, 2246, 4212], 'group,': [2241, 2392], 'order': [2243, 4176], 'descending': [2245], 'probability.': [2247], 'Heavy': [2248], 'lines': [2249, 2257], 'chains': [2252], '(with': [2253], 'invented': [2254], 'identifiers);': [2255], 'lighter': [2256], 'observed': [2259, 2300, 2330, 2388, 3771], 'Vertically': [2261], 'aligned': [2262], 'identical': [2265], 'sequence,': [2267], 'instance': [2270], 'labeled': [2274, 2314, 2354], 'letter': [2277], 'highest': [2280, 4255], 'maps.': [2286], "A'": [2287], 'indistinguishable': [2289], 'exactly': [2295], 'peptides;': [2301, 2337], 'both': [2302, 2501, 3166], 'equally': [2304], 'exist': [2307], 'sample(s),': [2310], 'Swiss-Prot': [2318, 3824], 'identifier': [2320], 'preferred.': [2322], 'E': [2323], "A's": [2336], 'also': [2340], "A',": [2343], 'C,': [2344, 2350], 'D': [2352], 'distinguished': [2356], 'slightly': [2364], 'superscript': [2375], 'C': [2376], 'comprise': [2377], 'smallest': [2379], 'sufficient': [2383], 'thus': [2394], 'belong': [2395], 'covering': [2398], 'set.View': [2399], 'Large': [2400, 2673, 2736, 4290], 'Image': [2401, 2674, 2737], 'Figure': [2402, 2675, 2738], 'ViewerDownload': [2403, 2676, 2739], 'Hi-res': [2404, 2677, 2740], 'image': [2405, 2678, 2741], 'Download': [2406, 2679, 2742], '(PPT)Fig.': [2407, 2680], '3Plasma': [2408], 'determined': [2411], 'immunoassay': [2413], 'antibody': [2415, 2448, 2592], 'microarray': [2416, 2449, 2593], '(40Haab': [2418, 2562], 'Geierstanger': [2420, 2564], 'B.H.': [2421, 2565], 'Michailidis': [2422, 2566], 'Vitzthum': [2424, 2568], 'Forrester': [2426, 2570], 'Okon': [2428, 2572], 'Saviranta': [2430, 2574], 'Brinker': [2432, 2576], 'Sorette': [2434, 2578], 'Perlee': [2436, 2580], 'L.': [2437, 2581, 2997, 3914, 3924, 4128], 'Suresh': [2438, 2582], 'Drwal': [2440, 2584], 'Immunoassay': [2446, 2590], 'specimens:': [2458, 2602], 'systematic': [2459, 2603], 'variation': [2460, 2604], 'between': [2461, 2605, 3260], 'types': [2463, 2607], 'calibration': [2465, 2609], 'spectrometry': [2468, 2612, 3392], 'data.Proteomics.': [2469, 2613], '3278-3291Crossref': [2472, 2616], '(129)': [2475, 2619], 'versus': [2478], 'normalized': [2479], 'counts': [2481], 'Non-glyco': [2486, 2641], 'plotted': [2488], 'log': [2491], 'scale.': [2492], 'Each': [2493, 2686, 3255, 4064], 'small': [2494], 'square': [2495], 'represents': [2496, 2688], 'found': [2499, 4311], 'sources.': [2502], 'Hollow': [2503], 'squares': [2504], 'excluded': [2509], 'when': [2510], 'drawing': [2511], 'trend': [2513, 2531], 'line': [2514, 2525, 2532], '(either': [2515], 'depleted': [2516], '(albumin)': [2517], 'spectrum': [2522, 2624], 'counts).': [2523], 'segments': [2526], 'below': [2529], 'fit': [2534], 'deviation': [2538], 'y': [2541], 'axis': [2542], 'values': [2543], 'computed': [2544, 3637], 'intervals': [2546], '0.1': [2548], '(log': [2549], 'scale).': [2550], 'arrows': [2552, 2662], 'left': [2555, 3595], 'counts.': [2625], 'histogram': [2627], 'right': [2630], 'depicts': [2631], 'completeness': [2636], 'function': [2645], 'concentration,': [2647], 'calculated': [2648], 'points': [2653, 2660], 'divided': [2654], 'total': [2657, 2711, 3270, 3276], 'decade.': [2665], 'See': [2666, 2725, 3540], 'supplemental': [2667, 2697, 2726, 3137, 3541, 3597], 'Fig.': [2668, 2727, 3593], 'S2,': [2669], 'N-Glyco': [2671], 'atlas.View': [2672], '4Proteins': [2681], 'experiment.': [2685, 4211], 'bar': [2687, 2703, 2721], '91': [2692, 2749], 'ordered': [2694], 'Table': [2698, 3138], 'S4.': [2699], 'Height': [2700], 'dark': [2702], 'per': [2709], 'experiment;': [2710], 'height': [2712], '(dark': [2713], 'light)': [2715], 'cumulative': [2717], 'tally;': [2718], 'width': [2719], 'PSM': [2723, 3815, 4065, 4084, 4117, 4193], 'count.': [2724], 'S5,': [2728], 'graph': [2732], 'peptides.View': [2735], '(PPT)': [2743], 'collected': [2745], '((4Omenn': [2754], '12Chan': [2874], '17Qian': [2891], 'W.J.': [2892, 3025, 3062], 'Monroe': [2893, 3031, 3071], 'M.E.': [2894, 3032, 3072, 3369], 'Liu': [2895, 2991], 'G.A.': [2900], 'Calvano': [2909], 'S.E.': [2910, 3426], 'Lowry': [2911], 'S.F.': [2912], 'Moldawer': [2915, 3067], 'L.L.': [2916, 3068], 'Quantitative': [2926, 3212], 'vivo': [2934], 'lipopolysaccharide': [2935], 'administration': [2936], '16O/18O': [2938], 'labeling': [2939], 'accurate': [2942], 'time': [2945], 'tag': [2946], 'approach.Mol.': [2947], '700-709Abstract': [2952], '(158)': [2960], '18Whiteaker': [2963], 'J.R.': [2964], 'Piening': [2971], 'B.D.': [2972], 'Feng': [2973], 'L.C.': [2974], 'Lorentzen': [2975], 'Schoenherr': [2977], 'R.M.': [2978], 'Keane': [2979], 'J.F.': [2980], 'Holzman': [2981], 'Fitzgibbon': [2983], 'C.': [2986, 3864], 'Cooke': [2989], 'K.': [2990, 3357, 3862, 3904, 3934, 3956], 'Watts': [2998], 'McIntosh': [3002], 'M.W.': [3003], 'Paulovich': [3004], 'A.G.': [3005], 'Head-to-head': [3006], 'comparison': [3007], 'fractionation': [3010, 3180], 'techniques.J.': [3011], 'Res.': [3013, 3050, 3498, 3882, 4014], '2007;': [3014, 3443, 3842], '6:': [3015], '828-836Crossref': [3016], '(142)': [3019], '19Liu': [3022], 'Gritsenko': [3026, 3063], 'N-glycoproteome': [3039], 'immunoaffinity': [3042], 'subtraction,': [3043], 'hydrazide': [3044], 'chemistry,': [3045], 'spectrometry.J.': [3048], '2070-2080Crossref': [3053], '(372)': [3056], '20Liu': [3059], 'Kaushal': [3069], 'Purvine': [3077], 'S.O.': [3078], 'Maier': [3079], 'R.V.': [3080], 'High': [3090, 3210], 'trauma': [3096], 'patient': [3097], '1899-1913Abstract': [3104], '(137)': [3112], '21Armandola': [3115], 'profiling': [3118], 'body': [3120], 'fluids': [3121], 'cancer': [3124], 'cell': [3125], 'signaling.Med.': [3126], 'Gen.': [3127], '18PubMed': [3131], 'unpublished;': [3136], 'S4,': [3139], 'Supplemental': [3140], 'Data),': [3141], '44': [3143], '13': [3149], 'II,': [3153], 'set,': [3157], 'corporate': [3161], 'research': [3162], 'Data': [3164, 3331, 3542, 3598], '(depleted/not': [3177], 'depleted,': [3178], 'schemata,': [3181], 'use': [3182], 'inhibitors,': [3185], 'N-linked': [3186], 'glycocapture': [3187, 3296], 'enrichment': [3188], '(22Zhang': [3189], 'Mallick': [3195], 'Kelly-Spratt': [3197], 'K.S.': [3198], 'Masselon': [3199], 'C.D.': [3200], '3rd,': [3202], 'Kemp': [3206], 'C.J.': [3207], 'Throughput': [3211], 'Analysis': [3213], 'Serum': [3215], 'Glycopeptide': [3218], 'Capture': [3219], 'Liquid': [3221], 'Chromatography': [3222], 'Mass': [3223, 3468], 'Spectrometry.Mol.': [3224], 'Cell.': [3225], '144-155Abstract': [3229], '(189)': [3237], 'Scholar)),': [3239], 'included.': [3248], 'All': [3249], 'samples': [3250, 3311], 'digested': [3252], 'trypsin.': [3254], 'consisted': [3258], '38,252': [3263], 'runs': [3265, 3274], '(median': [3266], '22)': [3267], '48,789': [3272], '2This': [3275], 'extraordinarily': [3279], 'together': [3282], 'comprising': [3283], '45,160': [3284], 'runs..': [3285], 'analysis,': [3287], 'nonglycocapture,': [3298], 'later': [3300], 'results.': [3303], '69': [3305], 'nonglycocapture': [3310], 'ion': [3316, 3327], 'trap': [3317, 3328], 'wished': [3321], 'them': [3324], 'against': [3325, 3451], 'library.': [3330], 'converted': [3333], 'mzXML': [3335], '(23Pedrioli': [3336], 'P.G.': [3337], 'Hubley': [3340], 'Vogelzang': [3342], 'Deutsch': [3344, 3417, 3478], 'Raught': [3346], 'Pratt': [3348], 'Nilsson': [3350], 'Angeletti': [3352], 'R.H.': [3353], 'Cheung': [3356], 'Costello': [3358], 'C.E.': [3359], 'Julian': [3364], 'R.K.': [3365], 'McComb': [3368], 'Oliver': [3370], 'S.G.': [3371], 'Paton': [3374], 'N.W.': [3375], 'C.F.': [3381], 'Zhu': [3382], 'common': [3387], 'representation': [3389], 'application': [3396], 'research.Nat.': [3399], '22:': [3402], '1459-1466Crossref': [3403], '(649)': [3406], 'SpectraST': [3412, 3545], 'version': [3413], '4.0': [3414], '(24Lam': [3415], 'Stein': [3425], 'Development': [3429], 'library': [3435, 3454, 3462, 3493, 3513], 'searching': [3436, 3494], 'MS/MS.Proteomics.': [3442], '7:': [3444], '655-667Crossref': [3445], '(387)': [3448], 'consisting': [3455], 'NIST': [3458, 3510], '3.0': [3459, 3535], '(261,777': [3463], 'consensus': [3464, 3515], 'spectra)': [3465], '(25NIST': [3466], 'Peptide': [3467], 'Spectral': [3469], 'Libraries': [3470], 'http://peptide.nist.govGoogle': [3471], 'SpectraST-generated': [3475], '(26Lam': [3476], 'Artificial': [3482], 'decoy': [3483, 3507], 'libraries': [3485], 'estimation': [3490], 'proteomics.J.': [3496], '2010;': [3499], '9:': [3500], '605-610Crossref': [3501], '(79)': [3504], 'spectrum.': [3511], 'actual': [3519], 'spectra,': [3521], 'some': [3522], 'missed': [3526], 'cleavages': [3527], 'and/or': [3528, 4056], 'modifications.': [3529], 'precursor': [3531, 3748, 3769], 'tolerance': [3533], 'Th': [3536], '(thomson)': [3537], 'used.': [3539], 'complete': [3544], 'parameters.': [3546], 'experiment': [3552, 4292], 'processed': [3554], '(TPP)': [3559], 'shown': [3591], '1,': [3594], '(see': [3596], 'TPP': [3600], 'used).': [3602], '(PSM)': [3644], 'length': [3648], 'seven': [3649], 'greater.': [3651], 'iProphet': [3652], '(27Shteynberg,': [3653], 'D.,': [3654], 'Deutsch,': [3655], 'E.,': [3656], 'Lam,': [3657], 'H.,': [3658], 'Eng,': [3659], 'J.,': [3660], 'Sun,': [3661], 'Z.,': [3662], 'Tasman,': [3663], 'N.,': [3664], 'Mendoza,': [3665], 'L.,': [3666, 3669], 'Moritz,': [3667], 'Aebersold,': [3670], 'R.,': [3671], 'Nesvizhskii,': [3672], 'I.,': [3674], '(submitted)': [3675], 'iProphet:': [3676], 'Improved': [3677], 'shotgun': [3684], 'proteomics.': [3685], 'Mol.': [3686, 3840], 'ProteomicsGoogle': [3688], 'improve': [3697], 'discrimination': [3698], 'modeling': [3700], 'five': [3701, 3718], 'additional': [3702], 'properties': [3703], 'beyond': [3707], 'modeled': [3709], 'PeptideProphet,': [3711], 'adjusting': [3713, 4260], 'probabilities': [3715, 4262], 'accordingly.': [3716], 'models': [3719], 'sibling': [3723, 3763, 3790, 3803, 4267], 'searches': [3724], '(rewards': [3725, 3792, 3805], 'penalizes': [3727], 'output': [3732], 'engines,': [3736], 'applicable': [3738], 'here),': [3739], 'replicate': [3742], '(models': [3744, 3765], 'assumption': [3746, 3767], 'ions': [3749, 3770, 3791], 'correct),': [3760, 3787], 'precursors': [3796], 'charges),': [3799], 'modifications': [3804], 'modifications).': [3811], 'RefreshParser': [3812], 'splice': [3827, 4093], 'variants': [3828], '(28Boutet': [3829], 'Lieberherr': [3831], 'Tognolli': [3833], 'Schneider': [3835, 3869], 'Bairoch': [3837, 3849], 'UniProtKB/Swiss-Prot.Methods': [3839], '406:': [3843], '89-112PubMed': [3844], '29Boeckmann': [3847], 'Blatter': [3853], 'M.C.': [3854], 'Estreicher': [3855], 'Gasteiger': [3857], 'Martin': [3859], 'M.J.': [3860], 'Michoud': [3861], "O'Donovan": [3863], 'Phan': [3865], 'Pilbout': [3867], 'SWISS-PROT': [3872], 'knowledgebase': [3874], 'supplement': [3877], 'TrEMBL': [3878], '2003.Nucleic': [3880], 'Acids': [3881, 4013], '31:': [3884], '365-370Crossref': [3885], '(2745)': [3888], 'v3.71,': [3892], 'v57.37': [3894], '(30Hubbard': [3895], 'T.J.': [3896], 'Aken': [3897], 'B.L.': [3898], 'Ayling': [3899], 'Ballester': [3901], 'Beal': [3903], 'Bragin': [3905], 'Brent': [3907], 'Chen': [3909], 'Clapham': [3911], 'Clarke': [3913], 'Coates': [3915], 'Fairley': [3917], 'Fitzgerald': [3919], 'Fernandez-Banet': [3921], 'Gordon': [3923], 'Graf': [3925], 'Haider': [3927], 'Hammond': [3929], 'Holland': [3931], 'Howe': [3933], 'Jenkinson': [3935], 'Johnson': [3937], 'Kahari': [3939], 'Keefe': [3941], 'Keenan': [3943], 'Kinsella': [3945], 'Kokocinski': [3947], 'Kulesha': [3949], 'Lawson': [3951], 'Longden': [3953], 'Megy': [3955], 'Meidl': [3957], 'Overduin': [3959], 'Parker': [3961], 'Pritchard': [3963], 'Rios': [3965], 'Schuster': [3967], 'Slater': [3969], 'Smedley': [3971], 'Spooner': [3973], 'Spudich': [3975], 'Trevanion': [3977], 'Vilella': [3979], 'Vogel': [3981], 'White': [3983], 'Wilder': [3985], 'Zadissa': [3987], 'Cunningham': [3991], 'Curwen': [3993], 'Durbin': [3995], 'Fernandez-Suarez': [3997], 'X.M.': [3998], 'Herrero': [3999], 'Kasprzyk': [4001], 'Proctor': [4003], 'Searle': [4007], 'Flicek': [4009], '2009.Nucleic': [4012], '2009;': [4015, 4161], '37:': [4016], 'D690-697Crossref': [4017], '(689)': [4020], 'cRAP': [4024], 'v1.0': [4025], '(31cRAP,': [4026], 'Common': [4027], 'Repository': [4028], 'Adventitious': [4030], 'Proteins.http://www.thegpm.org/cRAPGoogle': [4031], 'cases,': [4035], 'included': [4042], 'contained': [4052], 'databases': [4055], 'duplicates.': [4063], "PSM's": [4074], 'sequence;': [4076], 'cases': [4079], 'duplicates,': [4092], 'variants,': [4094], 'paralogs.': [4096], 'FDR': [4103, 4183, 4194], 'level': [4107], 'tends': [4108], 'level,': [4118, 4123], 'still': [4126], '(32Reiter': [4127], 'Claassen': [4129], 'Schrimpf': [4131], 'S.P.': [4132], 'Jovanovic': [4133], 'Schmidt': [4135], 'Buhmann': [4137], 'Hengartner': [4139], 'M.O.': [4140], '8:': [4162], '2405-2417Abstract': [4163], '(251)': [4171], 'Thus,': [4174], 'obtain': [4178], 'decoy-estimated': [4181], 'final': [4186], 'PeptideProphet-estimated': [4192], 'filter': [4195], '0.0002': [4197], '(corresponding': [4198], 'cutoffs': [4201], 'ranging': [4202], '0.9903': [4204], '0.9998)': [4206], '(33Nesvizhskii': [4213], 'Keller': [4215], 'identifying': [4225], 'spectrometry.Anal.': [4230], '75:': [4233], '4646-4658Crossref': [4234], '(3589)': [4237], 'then': [4241], 'run': [4242], 'experiment,': [4245], 'PSM,': [4257], 'further': [4259], 'these': [4261], 'rewards': [4271], 'map': [4274], 'HsSerum': [4288], 'NCI': [4289], 'Survey': [4291], 'contain': [4313], 'pep': [4315]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2142286883', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 16}, {'year': 2021, 'cited_by_count': 20}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 28}, {'year': 2018, 'cited_by_count': 26}, {'year': 2017, 'cited_by_count': 34}, {'year': 2016, 'cited_by_count': 41}, {'year': 2015, 'cited_by_count': 60}, {'year': 2014, 'cited_by_count': 49}, {'year': 2013, 'cited_by_count': 64}, {'year': 2012, 'cited_by_count': 48}], 'updated_date': '2025-01-05T15:03:10.359658', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
