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[60], 'George': [62, 350, 1718], 'M.': [63, 351, 353, 1719], 'Yousef': [64, 354, 1391, 1720], 'ChowTsz-fung': [67], 'Chow': [69, 888, 1461], 'Department': [70, 95, 120, 144, 169, 194, 219, 244, 274, 304, 327, 355, 371, 1462, 1485, 1508, 1530, 1553, 1576, 1599, 1622, 1649, 1677, 1697, 1721, 1737], 'Laboratory': [72, 97, 146, 171, 196, 221, 246, 357, 373, 1464, 1487, 1532, 1555, 1578, 1601, 1624, 1723, 1739], 'Medicine': [73, 98, 147, 172, 197, 222, 247, 358, 374, 1465, 1488, 1533, 1556, 1579, 1602, 1625, 1724, 1740], 'Keenan': [75, 100, 149, 174, 199, 224, 249, 360, 1467, 1490, 1535, 1558, 1581, 1604, 1627, 1726], 'Research': [76, 101, 150, 175, 200, 225, 250, 361, 1468, 1491, 1536, 1559, 1582, 1605, 1628, 1727], 'Centre,': [77, 102, 151, 176, 201, 226, 251, 362, 1469, 1492, 1537, 1560, 1583, 1606, 1629, 1728], 'Li': [78, 103, 152, 177, 202, 227, 252, 363, 1470, 1493, 1538, 1561, 1584, 1607, 1630, 1729], 'Ka': [79, 104, 153, 178, 203, 228, 253, 364, 1471, 1494, 1539, 1562, 1585, 1608, 1631, 1730], 'Shing': [80, 105, 154, 179, 204, 229, 254, 365, 1472, 1495, 1540, 1563, 1586, 1609, 1632, 1731], 'Knowledge': [81, 106, 155, 180, 205, 230, 255, 366, 1473, 1496, 1541, 1564, 1587, 1610, 1633, 1732], 'Institute,': [82, 107, 156, 181, 206, 231, 256, 367, 1474, 1497, 1542, 1565, 1588, 1611, 1634, 1733], 'Toronto,': [83, 108, 157, 182, 207, 232, 257, 280, 310, 333, 368, 379, 380, 1475, 1498, 1543, 1566, 1589, 1612, 1635, 1655, 1683, 1703, 1734, 1745, 1746], 'Ontario,': [84, 109, 158, 183, 208, 233, 258, 281, 311, 334, 369, 381, 1476, 1499, 1544, 1567, 1590, 1613, 1636, 1656, 1684, 1704, 1735, 1747], 'Canada': [85, 110, 159, 184, 209, 234, 259, 282, 312, 335, 370, 382, 1477, 1500, 1545, 1568, 1591, 1614, 1637, 1657, 1685, 1705, 1736, 1748], 'More': [86, 111, 135, 160, 185, 210, 235, 260, 292, 313, 343, 383, 1478, 1501, 1523, 1546, 1569, 1592, 1615, 1638, 1667, 1686, 1713, 1749], 'articles': [87, 112, 136, 161, 186, 211, 236, 261, 293, 314, 344, 384, 1479, 1502, 1524, 1547, 1570, 1593, 1616, 1639, 1668, 1687, 1714, 1750], 'by': [88, 113, 137, 162, 187, 212, 237, 262, 294, 315, 345, 385, 485, 530, 575, 782, 842, 956, 1219, 1265, 1323, 1452, 1480, 1503, 1525, 1548, 1571, 1594, 1617, 1640, 1669, 1688, 1715, 1751], 'this': [89, 114, 138, 163, 188, 213, 238, 263, 295, 316, 346, 386, 430, 454, 1481, 1504, 1526, 1549, 1572, 1595, 1618, 1641, 1670, 1689, 1716, 1752], 'author': [90, 115, 139, 164, 189, 214, 239, 264, 296, 317, 347, 387, 1482, 1505, 1527, 1550, 1573, 1596, 1619, 1642, 1671, 1690, 1717, 1753], ',': [91, 116, 140, 165, 190, 215, 240, 265, 297, 318, 348], 'MankaruosMarina': [93], 'Mankaruos': [94, 1484], 'ScorilasAndreas': [118], 'Scorilas': [119, 942, 1507], 'Biochemistry': [122, 1510], 'Molecular': [124, 1512], 'Biology,': [125, 128, 1513, 1516], 'Faculty': [126, 1514], 'University': [129, 377, 1517, 1743], 'Athens,': [131, 133, 1519, 1521], 'Panepistimiopolis,': [132, 1520], 'Greece': [134, 1522], 'YoussefYoussef': [142], 'GirgisAndrew': [167], 'Girgis': [168, 1374, 1552], 'MossadSarah': [192], 'Mossad': [193, 1575], 'MetiasShereen': [217], 'Metias': [218, 1380, 1598], 'RofaelYostina': [242], 'Rofael': [243, 1621], 'HoneyR.': [268], 'Honey': [270, 1382, 1645], 'Division': [271, 301, 324, 1646, 1674, 1694], 'Urology,': [273, 303, 326, 1357, 1415, 1648, 1676, 1696], 'Surgery,': [276, 306, 329, 1651, 1679, 1699], 'St.': [277, 307, 330, 1652, 1680, 1700], "Michael's": [278, 308, 331, 1653, 1681, 1701], 'Hospital,': [279, 309, 332, 1654, 1682, 1702], 'Financial': [283, 336, 1658, 1706], 'interest': [284, 337, 1659, 1707], 'and/or': [285, 338, 1660, 1708], 'other': [286, 339, 1661, 1709], 'relationship': [287, 340, 1662, 1710], 'with': [288, 341, 476, 1287, 1663, 1711], 'Cook': [289, 1664], 'Pleuromed.': [291, 1666], 'StewartRobert': [299], 'Stewart': [300, 1384, 1673], 'PaceKenneth': [321], 'Pace': [323, 1386, 1693], 'Sanofi-Synthelabo.': [342, 1712], 'YousefGeorge': [352], 'Pathobiology,': [376, 1742], 'View': [388], 'All': [389, 1755], 'Author': [390], 'Informationhttps://doi.org/10.1016/j.juro.2009.09.086AboutFull': [391], 'TextPDF': [392], 'ToolsAdd': [393], 'to': [394, 563, 568, 977, 1087, 1342], 'favoritesDownload': [395], 'CitationsTrack': [396], 'CitationsPermissionsReprints': [397], 'ShareFacebookLinked': [398], 'InTwitterEmail': [399], 'Abstract': [400], 'Purpose:': [401], 'miRNAs': [402, 419, 584, 676], 'are': [403, 409, 421, 664, 677], 'small,': [404], 'nonprotein': [405], 'coding': [406], 'RNAs': [407], 'that': [408, 420, 592], 'differentially': [410], 'expressed': [411, 556], 'many': [413, 669], 'malignancies.': [414], 'We': [415, 462, 518, 598], 'previously': [416], 'identified': [417, 580, 600], '80': [418], 'dysregulated': [422, 515, 585, 649, 656, 675, 927], 'clear': [424, 441, 470, 525, 587, 608, 633, 659, 670, 968], 'cell': [425, 427, 442, 444, 471, 473, 492, 505, 526, 528, 542, 560, 565, 588, 590, 609, 611, 634, 636, 660, 662, 671, 673, 711, 903, 920, 951, 969, 971, 1000, 1044, 1151, 1249, 1290, 1312], 'renal': [426, 443, 472, 503, 527, 589, 610, 635, 661, 672, 902, 919, 950, 970, 979, 999, 1150, 1311], 'carcinoma.': [428, 1152, 1313], 'In': [429], 'study': [431], 'we': [432], 'validated': [433, 484, 519], 'over': [434, 522], 'expression': [435, 482, 523, 596, 722, 761, 897, 996, 1018, 1040, 1075], 'the': [437, 448, 465, 558, 594, 619, 813, 916, 1077, 1088, 1142, 1246, 1308], 'cluster': [439, 455, 521, 746, 1261], 'carcinoma': [445, 474, 529, 591, 612, 637, 663, 674, 904, 1085], 'tested': [447, 500], 'effect': [449, 494, 572], '2': [451, 696], 'members': [452], '(miR-17-5p': [456], 'miR-20a)': [458], 'tumor': [460], 'proliferation.': [461, 712], 'also': [463, 599], 'elucidated': [464], 'role': [466, 743], 'miRNA': [468, 481, 614, 666, 721, 1116, 1394, 1412], 'pathogenesis': [475, 917], 'bioinformatics.': [477], 'Materials': [478], 'Methods:': [480], 'was': [483, 499, 573, 624], 'quantitative': [486, 531], 'reverse': [487, 532], 'transcriptase-polymerase': [488, 533], 'chain': [489, 534], 'reaction.': [490, 535], 'The': [491, 1238], 'proliferation': [493, 543, 566, 1288], 'miR-17-5p': [496, 576, 1223, 1239], 'miR-20a': [498, 538, 1225], 'a': [502, 545, 687, 808, 860, 974, 1121, 1181, 1242, 1335], 'adenocarcinoma': [504], 'line': [506], 'model.': [507], 'Multiple': [508], 'silico': [510, 1168], 'analyses': [511], 'were': [512, 645], 'done': [513, 625], 'miRNAs.': [516, 620, 650], 'Results:': [517], 'miR-71-92': [520], 'Transfection': [536, 549], 'inhibitor': [539], 'significantly': [540], 'decreased': [541], 'dose': [546], 'dependent': [547], 'manner.': [548], 'miR-17-5p,': [551], 'which': [552], 'not': [554], 'endogenously': [555], 'ACHN': [559], 'line,': [561], 'led': [562], 'increased': [564], 'compared': [567], 'control': [569], 'values.': [570], 'This': [571], 'suppressed': [574], 'inhibitor.': [577], 'Bioinformatics': [578], 'analysis': [579, 623, 925], '10': [581, 873], 'clusters': [582], 'followed': [593], 'same': [595], 'patterns.': [597], 'matching': [601], 'patterns': [602], 'between': [603], 'reported': [604], 'chromosomal': [605, 1102], 'aberration': [606], 'dysregulation': [615], 'for': [616, 648, 863, 1124, 1396], '37.5%': [617], 'Target': [621], 'prediction': [622], 'using': [626], 'multiple': [627], 'algorithms.': [628], 'Many': [629], 'key': [630, 1243], 'molecules': [631], 'pathogenesis,': [638], 'including': [639], 'HIFs,': [640], 'mTOR,': [641], 'VEGF': [642], 'VHL,': [644], 'potential': [646, 665, 688], 'targets': [647, 1021], 'Conclusions:': [651], 'A': [652, 683, 698, 943, 1137], 'significant': [653, 1002], 'number': [654], 'proteins': [657, 785], 'targets.': [667], 'Also,': [668], 'phylogenetically': [678], 'conserved.': [679], 'References': [680], '1': [681], ':': [682, 697, 720, 741, 759, 778, 804, 833, 853, 874, 914, 964, 993, 1015, 1033, 1055, 1073, 1099, 1113, 1136, 1161, 1179, 1194, 1216, 1237, 1259, 1282, 1299], 'microRNA': [684, 700, 865, 995, 1035, 1164, 1240, 1304], 'polycistron': [685, 1079], 'as': [686, 859, 1163, 1339], 'human': [689, 706, 765, 1119], 'oncogene.': [690], 'Nature2005;': [691], '435:': [692], '828.': [693], 'Google': [694, 717, 738, 756, 775, 801, 830, 850, 871, 885, 911, 935, 961, 990, 1012, 1030, 1052, 1070, 1096, 1110, 1133, 1158, 1176, 1191, 1213, 1234, 1256, 1279, 1296, 1319], 'Scholar': [695, 718, 739, 757, 776, 802, 831, 851, 872, 886, 912, 936, 962, 991, 1013, 1031, 1053, 1071, 1097, 1111, 1134, 1159, 1177, 1192, 1214, 1235, 1257, 1280, 1297, 1320], 'polycistronic': [699], 'cluster,': [701], 'miR-17-92,': [702, 817], 'overexpressed': [704], 'lung': [707, 1227], 'cancers': [708, 1228], 'enhances': [710], 'Cancer': [713, 752, 867, 1128, 1153, 1292, 1315], 'Res2005;': [714], '65:': [715], '9628.': [716], '3': [719, 1147], 'profiles': [723], 'chronic': [725], 'lymphocytic': [726, 729], 'acute': [728, 794], 'leukemia.': [730, 796], 'Braz': [731], 'J': [732, 880, 981, 1008, 1092], 'Med': [733], 'Biol': [734, 881, 931, 1172, 1187], 'Res2007;': [735], '40:': [736], '1435.': [737], '4': [740], 'anaplastic': [748], 'thyroid': [749], 'cancer': [750, 809, 972, 1105, 1125], 'cells.': [751, 1106], 'Sci2008;': [753], '99:': [754], '1147.': [755], '5': [758], 'Overlapping': [760], 'microRNAs': [763, 900], 'embryonic': [766], 'colon': [767], 'colorectal': [769], 'cancer.': [770], 'Res2008;': [772, 868, 1316], '18:': [773], '823.': [774], '6': [777], 'Activation': [779], 'NK-like': [783], 'homeodomain': [784], 'suppresses': [786], 'apoptosis': [787], 'via': [788], 'reduction': [789], 'E2F1': [791, 843], 'T-cell': [793], 'lymphoblastic': [795], 'Leuk': [797], 'Lymphoma2009;': [798], '50:': [799], '101.': [800], '7': [803], 'MicroRNA': [805, 965, 1060], 'regulation': [806], 'network:': [810], 'consequences': [811], 'feedback': [814, 878], 'loops': [815], 'involving': [816], 'E2F,': [818], 'Myc.': [820], 'Proc': [821, 1270], 'Natl': [822, 1271], 'Acad': [823, 1272], 'Sci': [824, 1063, 1273], 'U': [825, 1274], 'S': [826, 1275], 'A2008;': [827, 1276], '105:': [828, 1277], '19678.': [829], '8': [832], 'Protein': [834], 'tyrosine': [835], 'phosphatase': [836], 'receptor-type': [837], 'O': [838], '(PTPRO)': [839], 'co-regulated': [841], 'miR-17-92.': [845, 1230], 'FEBS': [846], 'Lett2008;': [847], '582:': [848], '2850.': [849], '9': [852], 'Identification': [854, 1405], 'hypoxia-inducible': [856], 'factor-1': [857], 'alpha': [858], 'novel': [861], 'target': [862], 'cluster.': [866], '68:': [869], '5540.': [870], 'An': [875], 'E2F/miR-20a': [876], 'autoregulatory': [877], 'loop.': [879], 'Chem2007;': [882], '282:': [883], '2135.': [884], '11': [887], 'T,': [889, 1369], 'Y,': [891, 1373], 'Lianidou': [892], 'E': [893], 'et': [894, 944], 'al:': [895, 945], 'Differential': [896, 946], 'profiling': [898, 966, 997], 'their': [906], 'clinical': [907], 'implications.': [908], 'Unpublished': [909, 959], 'data.': [910, 960], '12': [913], 'Exploring': [915], 'carcinoma:': [921, 952, 1001], 'pathway': [922], 'bioinformatics': [924], 'genes': [928, 1306], 'proteins.': [930], 'Chem2009;': [932], '390:': [933], '125.': [934], '13': [937], 'Siu': [938], 'KWM,': [939], 'Desouza': [940], 'L,': [941], 'protein': [947], 'expressions': [948], 'new': [953, 1122, 1182], 'biomarker': [954], 'discovery': [955], 'mass': [957], 'spectrometry.': [958], '14': [963], 'identifies': [973], 'robust': [975], 'signature': [976], 'define': [978], 'malignancy.': [980], 'Mol': [983], 'Med2009;': [984], '.': [985, 1208], 'Epub': [986, 1209], 'ahead': [987, 1210], 'print.': [989, 1212], '15': [992], 'Genome-wide': [994], 'down-regulation': [1003], 'miR-141': [1005], 'miR-200c.': [1007], 'Pathol2008;': [1009, 1093], '216:': [1010], '418.': [1011], '16': [1014], 'MicroRNA-17-92': [1016], 'downregulates': [1017], 'distinct': [1020], 'different': [1023], 'B-cell': [1024], 'lymphoma': [1025], 'subtypes.': [1026], 'Blood2008;': [1027], '113:': [1028], '396.': [1029], '17': [1032], 'Human': [1034], 'clusters:': [1036], 'genomic': [1037], 'organization': [1038], 'profile': [1041], 'leukemia': [1043], 'lines.': [1045], 'Biochem': [1046], 'Biophys': [1047], 'Res': [1048], 'Commun2006;': [1049], '349:': [1050], '59.': [1051], '18': [1054], 'Diversity': [1056], 'evolution': [1058], 'gene': [1061, 1126], 'clusters.': [1062], 'China': [1064], 'C': [1065], 'Life': [1066], 'Sci2009;': [1067], '52:': [1068], '261.': [1069], '19': [1072], 'Elevated': [1074], 'miR-21': [1081], 'hepadnavirus-associated': [1083], 'hepatocellular': [1084], 'contributes': [1086], 'malignant': [1089], 'phenotype.': [1090], 'Am': [1091], '173:': [1094], '856.': [1095], '20': [1098], 'MicroRNAs': [1100, 1195], 'abnormalities': [1103], 'Oncogene2006;': [1107], '25:': [1108], '6202.': [1109], '21': [1112], 'Modulation': [1114], 'activity': [1117], 'cancer:': [1120, 1197], 'paradigm': [1123], 'therapy?.': [1127], 'Gene': [1129], 'Ther2008;': [1130], '15:': [1131], '341.': [1132], '22': [1135], 'detailed': [1138], 'deletion': [1139], 'mapping': [1140], 'short': [1143], 'arm': [1144], 'chromosome': [1146], 'sporadic': [1149], 'Res1991;': [1154], '51:': [1155], '4707.': [1156], 'Medline,': [1157], '23': [1160], 'Kallikreins': [1162], 'targets:': [1165], 'experimental-based': [1170], 'analysis.': [1171], 'Chem2008;': [1173, 1188], '389:': [1174, 1189], '731.': [1175], '24': [1178], 'MicroRNAs:': [1180], 'frontier': [1183], 'kallikrein': [1185], 'research.': [1186], '689.': [1190], '25': [1193], 'current': [1198], 'state': [1199], 'future': [1201], 'perspectives': [1202], 'urologic': [1204], 'oncology.': [1205], 'Urol': [1206], 'Oncol2008;': [1207], '26': [1215], 'Apoptosis': [1217], 'induction': [1218], 'antisense': [1220], 'oligonucleotides': [1221], 'against': [1222], 'overexpressing': [1229], 'Oncogene2007;': [1231], '26:': [1232], '6099.': [1233], '27': [1236], 'regulator': [1244], 'G1/S': [1247], 'phase': [1248], 'cycle': [1250], 'transition.': [1251], 'Genome': [1252], 'Biol2008;': [1253], '9:': [1254], 'R127.': [1255], '28': 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