Title: Chromosomal aberrations as detected by array comparative genomic hybridization in early low-grade intraepithelial neoplasias of the breast
Abstract: HistopathologyVolume 59, Issue 3 p. 549-555 Chromosomal aberrations as detected by array comparative genomic hybridization in early low-grade intraepithelial neoplasias of the breast Elvira Stacher, Elvira Stacher Institute of Pathology, Medical University of Graz, Graz, AustriaSearch for more papers by this authorVivien Boldt, Vivien Boldt Max-Planck-Institute of Molecular Genetics, Berlin, GermanySearch for more papers by this authorSebastian Leibl, Sebastian Leibl Institute of Pathology, Medical University of Graz, Graz, AustriaSearch for more papers by this authorIris Halbwedl, Iris Halbwedl Institute of Pathology, Medical University of Graz, Graz, AustriaSearch for more papers by this authorHelmut H Popper, Helmut H Popper Institute of Pathology, Medical University of Graz, Graz, AustriaSearch for more papers by this authorReinhard Ullmann, Reinhard Ullmann Max-Planck-Institute of Molecular Genetics, Berlin, GermanySearch for more papers by this authorFattaneh A Tavassoli, Fattaneh A Tavassoli Department of Pathology, Yale University School of Medicine, New Haven, CT, USASearch for more papers by this authorFarid Moinfar, Farid Moinfar Institute of Pathology, Medical University of Graz, Graz, AustriaSearch for more papers by this author Elvira Stacher, Elvira Stacher Institute of Pathology, Medical University of Graz, Graz, AustriaSearch for more papers by this authorVivien Boldt, Vivien Boldt Max-Planck-Institute of Molecular Genetics, Berlin, GermanySearch for more papers by this authorSebastian Leibl, Sebastian Leibl Institute of Pathology, Medical University of Graz, Graz, AustriaSearch for more papers by this authorIris Halbwedl, Iris Halbwedl Institute of Pathology, Medical University of Graz, Graz, AustriaSearch for more papers by this authorHelmut H Popper, Helmut H Popper Institute of Pathology, Medical University of Graz, Graz, AustriaSearch for more papers by this authorReinhard Ullmann, Reinhard Ullmann Max-Planck-Institute of Molecular Genetics, Berlin, GermanySearch for more papers by this authorFattaneh A Tavassoli, Fattaneh A Tavassoli Department of Pathology, Yale University School of Medicine, New Haven, CT, USASearch for more papers by this authorFarid Moinfar, Farid Moinfar Institute of Pathology, Medical University of Graz, Graz, AustriaSearch for more papers by this author First published: 10 September 2011 https://doi.org/10.1111/j.1365-2559.2011.03918.xCitations: 10 F Moinfar, MD, Unit of Breast and Gynaecologic Pathology, Institute of Pathology, Medical University of Graz, Auenbruggerplatz 25, A-8036 Graz, Austria. e-mail: [email protected] E.S. and V.B. contributed equally to this work. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Stacher E, Boldt V, Leibl S, Halbwedl I, Popper H H, Ullmann R, Tavassoli F A & Moinfar F(2011) Histopathology59, 549–555 Chromosomal aberrations as detected by array comparative genomic hybridization in early low-grade intraepithelial neoplasias of the breast Aims: Low-grade flat ductal intraepithelial neoplasia (DIN1a, flat epithelial atypia) is one of the earliest morphologically recognizable neoplastic lesions of the breast. Frequently, it occurs concomitantly with lobular intraepithelial neoplasia (LIN). We aimed to elucidate chromosomal aberrations in these early neoplastic breast lesions with the use of array comparative genomic hybridization analysis. Methods and results: Laser capture microdissection of 12 archival formalin-fixed, paraffin-embedded specimens harbouring foci of both DIN1a and LIN was performed. All analysed cases of DIN1a and LIN showed chromosomal gains and losses. The aberration encountered most often was loss of 16q, noted in seven DIN1a (70% of those successfully examined) and 10 LIN (91%) cases. The next most common alteration was a gain on 1q, noted in four DIN1a (40%) and seven LIN (64%) cases. Conclusions: The results show concurrent chromosomal aberrations of 1q gains and 16q losses in several cases with coexisting LIN and DIN1a. These aberrations are known to be common in low-grade invasive (ductal and lobular) carcinomas as well as in more advanced (conventional) types of low-grade ductal intraepithelial neoplasia (DIN) (low-grade ductal carcinoma in situ). Our results raise the possibility of similar molecular-genetic pathways in coexisting LIN and low-grade flat DIN. Supporting Information Table S1. Chromosomal intervals of all aberrations larger than 500 kb found in DIN and LIN, including case number and aberration type. Filename Description HIS_3918_sm_TableS1.doc231.5 KB Supporting info item Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. References 1 Moinfar F, Man YG, Bratthauer GL, Ratschek M, Tavassoli FA. 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Publication Year: 2011
Publication Date: 2011-09-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 15
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