Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2141504862', 'doi': 'https://doi.org/10.3892/mco.2013.151', 'title': 'Overexpression of heparan sulfate 6-O-sulfotransferase-2 in colorectal cancer', 'display_name': 'Overexpression of heparan sulfate 6-O-sulfotransferase-2 in colorectal cancer', 'publication_year': 2013, 'publication_date': '2013-07-23', 'ids': {'openalex': 'https://openalex.org/W2141504862', 'doi': 'https://doi.org/10.3892/mco.2013.151', 'mag': '2141504862', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24649258', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3915281'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/mco.2013.151', 'pdf_url': 'https://www.spandidos-publications.com/10.3892/mco.2013.151/download', 'source': {'id': 'https://openalex.org/S2754683124', 'display_name': 'Molecular and Clinical Oncology', 'issn_l': '2049-9450', 'issn': ['2049-9450', '2049-9469'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320412', 'host_organization_name': 'Spandidos Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320412'], 'host_organization_lineage_names': ['Spandidos Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.spandidos-publications.com/10.3892/mco.2013.151/download', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5002590458', 'display_name': 'Shigeru Hatabe', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'SHIGERU HATABE', 'raw_affiliation_strings': ['Department of Surgery, Kinki University School of Medicine, Osaka-Sayama, Osaka 589-8511, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Surgery, Kinki University School of Medicine, Osaka-Sayama, Osaka 589-8511, Japan.', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077306744', 'display_name': 'Hideharu Kimura', 'orcid': 'https://orcid.org/0000-0002-6558-7012'}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'HIDEHARU KIMURA', 'raw_affiliation_strings': ['Department of Genome Biology, Kinki University School of Medicine, Osaka‑Sayama, Osaka 589‑8511, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Genome Biology, Kinki University School of Medicine, Osaka‑Sayama, Osaka 589‑8511, Japan', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000324980', 'display_name': 'Tokuzo Arao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'TOKUZO ARAO', 'raw_affiliation_strings': ['Department of Genome Biology, Kinki University School of Medicine, Osaka‑Sayama, Osaka 589‑8511, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Genome Biology, Kinki University School of Medicine, Osaka‑Sayama, Osaka 589‑8511, Japan', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064027488', 'display_name': 'Hiroaki Kato', 'orcid': 'https://orcid.org/0000-0002-5993-4532'}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'HIROAKI KATO', 'raw_affiliation_strings': ['Department of Surgery, Kinki University School of Medicine, Osaka-Sayama, Osaka 589-8511, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Surgery, Kinki University School of Medicine, Osaka-Sayama, Osaka 589-8511, Japan.', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038101792', 'display_name': 'Hidetoshi Hayashi', 'orcid': 'https://orcid.org/0000-0001-8787-5587'}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'HIDETOSHI HAYASHI', 'raw_affiliation_strings': ['Department of Genome Biology, Kinki University School of Medicine, Osaka‑Sayama, Osaka 589‑8511, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Genome Biology, Kinki University School of Medicine, Osaka‑Sayama, Osaka 589‑8511, Japan', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101707712', 'display_name': 'Tomoyuki Nagai', 'orcid': 'https://orcid.org/0000-0003-1528-6665'}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'TOMOYUKI NAGAI', 'raw_affiliation_strings': ['Department of Genome Biology, Kinki University School of Medicine, Osaka‑Sayama, Osaka 589‑8511, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Genome Biology, Kinki University School of Medicine, Osaka‑Sayama, Osaka 589‑8511, Japan', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5106185594', 'display_name': 'Kazuko Matsumoto', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'KAZUKO MATSUMOTO', 'raw_affiliation_strings': ['Department of Genome Biology, Kinki University School of Medicine, Osaka‑Sayama, Osaka 589‑8511, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Genome Biology, Kinki University School of Medicine, Osaka‑Sayama, Osaka 589‑8511, Japan', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051123041', 'display_name': 'Marco A. De Velasco', 'orcid': 'https://orcid.org/0000-0002-4011-6572'}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'MARCO DE VELASCO', 'raw_affiliation_strings': ['Department of Genome Biology, Kinki University School of Medicine, Osaka‑Sayama, Osaka 589‑8511, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Genome Biology, Kinki University School of Medicine, Osaka‑Sayama, Osaka 589‑8511, Japan', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002405384', 'display_name': 'Yoshihiko Fujita', 'orcid': 'https://orcid.org/0000-0001-6321-2121'}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'YOSHIHIKO FUJITA', 'raw_affiliation_strings': ['Department of Genome Biology, Kinki University School of Medicine, Osaka‑Sayama, Osaka 589‑8511, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Genome Biology, Kinki University School of Medicine, Osaka‑Sayama, Osaka 589‑8511, Japan', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073377114', 'display_name': 'Go Yamanouchi', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210123203', 'display_name': 'Sumitomo Bakelite (Japan)', 'ror': 'https://ror.org/02kxw8q35', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210123203']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'GO YAMANOUCHI', 'raw_affiliation_strings': ['Sumitomo Bakelite Co., Ltd., Nishi-ku, Kobe 651-2241, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Sumitomo Bakelite Co., Ltd., Nishi-ku, Kobe 651-2241, Japan.', 'institution_ids': ['https://openalex.org/I4210123203']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058813836', 'display_name': 'Masao Fukushima', 'orcid': 'https://orcid.org/0000-0002-4372-6376'}, 'institutions': [{'id': 'https://openalex.org/I4210123203', 'display_name': 'Sumitomo Bakelite (Japan)', 'ror': 'https://ror.org/02kxw8q35', 'country_code': 'JP', 'type': 'company', 'lineage': ['https://openalex.org/I4210123203']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'MASAO FUKUSHIMA', 'raw_affiliation_strings': ['Sumitomo Bakelite Co., Ltd., Nishi-ku, Kobe 651-2241, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Sumitomo Bakelite Co., Ltd., Nishi-ku, Kobe 651-2241, Japan.', 'institution_ids': ['https://openalex.org/I4210123203']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079864042', 'display_name': 'Yasuhide Yamada', 'orcid': 'https://orcid.org/0000-0003-0692-8419'}, 'institutions': [{'id': 'https://openalex.org/I4210145079', 'display_name': 'National Cancer Center Hospital East', 'ror': 'https://ror.org/03rm3gk43', 'country_code': 'JP', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210145079']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'YASUHIDE YAMADA', 'raw_affiliation_strings': ['Department of Medical Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo 104-0045, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo 104-0045, Japan.', 'institution_ids': ['https://openalex.org/I4210145079']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077151296', 'display_name': 'Akihiko Ito', 'orcid': 'https://orcid.org/0000-0002-6116-1700'}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'AKIHIKO ITO', 'raw_affiliation_strings': ['Department of Pathology, Kinki University School of Medicine, Osaka‐Sayama, Osaka 589‐8511, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Pathology, Kinki University School of Medicine, Osaka‐Sayama, Osaka 589‐8511, Japan', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064774655', 'display_name': 'Kiyotaka Okuno', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'KIYOTAKA OKUNO', 'raw_affiliation_strings': ['Department of Surgery, Kinki University School of Medicine, Osaka-Sayama, Osaka 589-8511, Japan.'], 'affiliations': [{'raw_affiliation_string': 'Department of Surgery, Kinki University School of Medicine, Osaka-Sayama, Osaka 589-8511, Japan.', 'institution_ids': ['https://openalex.org/I916559398']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5004282323', 'display_name': 'Kazuto Nishio', 'orcid': 'https://orcid.org/0000-0002-8275-0846'}, 'institutions': [{'id': 'https://openalex.org/I916559398', 'display_name': 'Kindai University', 'ror': 'https://ror.org/05kt9ap64', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I916559398']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'KAZUTO NISHIO', 'raw_affiliation_strings': ['Department of Genome Biology, Kinki University School of Medicine, Osaka‑Sayama, Osaka 589‑8511, Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Genome Biology, Kinki University School of Medicine, Osaka‑Sayama, Osaka 589‑8511, Japan', 'institution_ids': ['https://openalex.org/I916559398']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.944, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 34, 'citation_normalized_percentile': {'value': 0.811177, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '1', 'issue': '5', 'first_page': '845', 'last_page': '850'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11131', 'display_name': 'Role of Extracellular Matrix in Biological Signaling', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11131', 'display_name': 'Role of Extracellular Matrix in Biological Signaling', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10602', 'display_name': 'Glycosylation in Health and Disease', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12287', 'display_name': 'Fibroblast Growth Factor Signaling Pathway', 'score': 0.9881, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/heparan-sulfate', 'display_name': 'Heparan Sulfate', 'score': 0.488625}], 'concepts': [{'id': 'https://openalex.org/C526805850', 'wikidata': 'https://www.wikidata.org/wiki/Q188874', 'display_name': 'Colorectal cancer', 'level': 3, 'score': 0.77713406}, {'id': 'https://openalex.org/C2781018059', 'wikidata': 'https://www.wikidata.org/wiki/Q207609', 'display_name': 'Oncogene', 'level': 4, 'score': 0.7016881}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.66481555}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.5431558}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.51451087}, {'id': 'https://openalex.org/C67082663', 'wikidata': 'https://www.wikidata.org/wiki/Q3523816', 'display_name': 'Molecular medicine', 'level': 4, 'score': 0.50298613}, {'id': 'https://openalex.org/C2778041096', 'wikidata': 'https://www.wikidata.org/wiki/Q424668', 'display_name': 'Heparan sulfate', 'level': 3, 'score': 0.49900055}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4974101}, {'id': 'https://openalex.org/C8415881', 'wikidata': 'https://www.wikidata.org/wiki/Q6839217', 'display_name': 'Microarray analysis techniques', 'level': 4, 'score': 0.43114933}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.38154447}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.36173105}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.36127254}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3250329}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.31918627}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.2704703}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.2614904}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.2348077}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.16780716}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.08734089}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/mco.2013.151', 'pdf_url': 'https://www.spandidos-publications.com/10.3892/mco.2013.151/download', 'source': {'id': 'https://openalex.org/S2754683124', 'display_name': 'Molecular and Clinical Oncology', 'issn_l': '2049-9450', 'issn': ['2049-9450', '2049-9469'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320412', 'host_organization_name': 'Spandidos Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320412'], 'host_organization_lineage_names': ['Spandidos Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3915281', 'pdf_url': 'https://europepmc.org/articles/pmc3915281?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc', 'license_id': 'https://openalex.org/licenses/cc-by-nc', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915281', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24649258', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.3892/mco.2013.151', 'pdf_url': 'https://www.spandidos-publications.com/10.3892/mco.2013.151/download', 'source': {'id': 'https://openalex.org/S2754683124', 'display_name': 'Molecular and Clinical Oncology', 'issn_l': '2049-9450', 'issn': ['2049-9450', '2049-9469'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320412', 'host_organization_name': 'Spandidos Publishing', 'host_organization_lineage': ['https://openalex.org/P4310320412'], 'host_organization_lineage_names': ['Spandidos Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 20, 'referenced_works': ['https://openalex.org/W1565276921', 'https://openalex.org/W1969445939', 'https://openalex.org/W1972078597', 'https://openalex.org/W1978661103', 'https://openalex.org/W2008581828', 'https://openalex.org/W2011762251', 'https://openalex.org/W2045253560', 'https://openalex.org/W2047986508', 'https://openalex.org/W2064942304', 'https://openalex.org/W2076788883', 'https://openalex.org/W2083432523', 'https://openalex.org/W2089450737', 'https://openalex.org/W2095708380', 'https://openalex.org/W2095745421', 'https://openalex.org/W2107983150', 'https://openalex.org/W2116715149', 'https://openalex.org/W2122687697', 'https://openalex.org/W2142226955', 'https://openalex.org/W2156014566', 'https://openalex.org/W2326026062'], 'related_works': ['https://openalex.org/W3209843007', 'https://openalex.org/W2807613378', 'https://openalex.org/W2800201886', 'https://openalex.org/W2777311301', 'https://openalex.org/W2772993264', 'https://openalex.org/W2604370214', 'https://openalex.org/W2588285805', 'https://openalex.org/W2259981584', 'https://openalex.org/W2076290497', 'https://openalex.org/W2004426597'], 'abstract_inverted_index': {'The': [0, 63, 103, 148], 'heparan': [1, 13, 41], 'sulfate': [2, 10, 14, 42], 'sulfotransferase': [3], 'gene': [4, 27, 46], 'family': [5, 28], 'catalyzes': [6], 'the': [7, 23, 40, 92, 106, 157, 186, 227, 248], 'transfer': [8], 'of': [9, 25, 66, 91, 101, 133, 160, 250], 'groups': [11], 'to': [12, 127, 211, 220], 'and': [15, 53, 72, 83, 110, 143, 189, 216], 'regulates': [16], 'various': [17, 73], 'growth': [18], 'factor-receptor': [19], 'signaling': [20], 'pathways.': [21], 'However,': [22, 192], 'involvement': [24], 'this': [26], 'in': [29, 49, 57, 68, 123, 140, 156, 165, 176, 214], 'cancer': [30, 51, 74, 145], 'biology': [31], 'has': [32], 'not': [33, 164, 230], 'been': [34], 'elucidated.': [35], 'It': [36], 'was': [37, 61, 95, 118, 154, 174, 181, 197, 209, 229], 'demonstrated': [38, 151], 'that': [39, 152, 235, 243], 'D-glucosaminyl': [43], '6-O-sulfotransferase-2': [44], '(HS6ST2)': [45], 'is': [47], 'overexpressed': [48, 120, 213], 'colorectal': [50], '(CRC)': [52], 'its': [54, 217], 'clinical': [55, 69], 'significance': [56], 'patients': [58, 178], 'with': [59, 199], 'CRC': [60, 70, 124, 161, 215], 'investigated.': [62], 'mRNA': [64, 117, 135], 'levels': [65, 132], 'HS6ST2': [67, 93, 107, 116, 134, 153, 173, 190, 196, 208, 236], 'samples': [71, 125], 'cell': [75, 146], 'lines': [76], 'were': [77, 113, 137], 'assessed': [78], 'using': [79, 97], 'a': [80, 200, 222, 239], 'microarray': [81], 'analysis': [82, 90, 150], 'quantitative': [84], 'RT-PCR,': [85], 'respectively.': [86], 'An': [87], 'immunohistochemical': [88], '(IHC)': [89], 'protein': [94], 'performed': [96], '102': [98], 'surgical': [99], 'specimens': [100], 'CRC.': [102, 251], 'correlations': [104], 'between': [105, 185], 'expression': [108, 136, 218], 'status': [109], 'clinicopathological': [111, 187], 'characteristics': [112, 188], 'then': [114], 'evaluated.': [115], 'significantly': [119], 'by': [121], '37-fold': [122], 'compared': [126], 'paired': [128], 'colonic': [129, 167], 'mucosa.': [130], 'High': [131], 'also': [138], 'observed': [139], 'colorectal,': [141], 'esophageal': [142], 'lung': [144], 'lines.': [147], 'IHC': [149], 'expressed': [155], 'cytoplasmic': [158], 'region': [159], 'cells,': [162], 'but': [163], 'normal': [166], 'mucosal': [168], 'cells.': [169], 'Positive': [170], 'staining': [171, 194], 'for': [172, 195], 'detected': [175], '40': [177], '(39.2%).': [179], 'There': [180], 'no': [182], 'significant': [183], 'association': [184], 'expression.': [191], 'positive': [193], 'associated': [198], 'poor': [201, 223], 'survival': [202], '(P=0.074,': [203], 'log-rank': [204], 'test).': [205], 'In': [206], 'conclusion,': [207], 'found': [210], 'be': [212, 221, 238], 'tended': [219], 'prognostic': [224], 'factor,': [225], 'although': [226], 'correlation': [228], 'significant.': [231], 'These': [232], 'findings': [233], 'indicate': [234], 'may': [237, 244], 'novel': [240], 'cancer-related': [241], 'marker': [242], 'provide': [245], 'insight': [246], 'into': [247], 'glycobiology': [249]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2141504862', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 3}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 5}], 'updated_date': '2024-09-01T00:09:58.906275', 'created_date': '2016-06-24'}