Publication Information

{'id': 'https://openalex.org/W2141322398', 'doi': 'https://doi.org/10.1074/jbc.m112.357707', 'title': 'δ-Tocopherol Reduces Lipid Accumulation in Niemann-Pick Type C1 and Wolman Cholesterol Storage Disorders', 'display_name': 'δ-Tocopherol Reduces Lipid Accumulation in Niemann-Pick Type C1 and Wolman Cholesterol Storage Disorders', 'publication_year': 2012, 'publication_date': '2012-10-04', 'ids': {'openalex': 'https://openalex.org/W2141322398', 'doi': 'https://doi.org/10.1074/jbc.m112.357707', 'mag': '2141322398', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23035117', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3537026'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m112.357707', 'pdf_url': 'http://www.jbc.org/article/S0021925820622335/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925820622335/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100601425', 'display_name': 'Miao Xu', 'orcid': 'https://orcid.org/0000-0001-9968-733X'}, 'institutions': [{'id': 'https://openalex.org/I4210148682', 'display_name': 'National Center for Advancing Translational Sciences', 'ror': 'https://ror.org/04pw6fb54', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210148682']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I2802390878', 'display_name': 'Sir Run Run Shaw Hospital', 'ror': 'https://ror.org/00ka6rp58', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2802390878']}, {'id': 'https://openalex.org/I76130692', 'display_name': 'Zhejiang University', 'ror': 'https://ror.org/00a2xv884', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I76130692']}], 'countries': ['CN', 'US'], 'is_corresponding': False, 'raw_author_name': 'Miao Xu', 'raw_affiliation_strings': ['National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892', 'Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China'], 'affiliations': [{'raw_affiliation_string': 'National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I4210148682', 'https://openalex.org/I1299303238']}, {'raw_affiliation_string': 'Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China', 'institution_ids': ['https://openalex.org/I2802390878', 'https://openalex.org/I76130692']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100349838', 'display_name': 'Ke Liu', 'orcid': 'https://orcid.org/0000-0002-0505-920X'}, 'institutions': [{'id': 'https://openalex.org/I4210148682', 'display_name': 'National Center for Advancing Translational Sciences', 'ror': 'https://ror.org/04pw6fb54', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210148682']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ke Liu', 'raw_affiliation_strings': ['National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892'], 'affiliations': [{'raw_affiliation_string': 'National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I4210148682', 'https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004192317', 'display_name': 'Manju Swaroop', 'orcid': 'https://orcid.org/0000-0002-0576-1664'}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210148682', 'display_name': 'National Center for Advancing Translational Sciences', 'ror': 'https://ror.org/04pw6fb54', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210148682']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Manju Swaroop', 'raw_affiliation_strings': ['National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892'], 'affiliations': [{'raw_affiliation_string': 'National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I1299303238', 'https://openalex.org/I4210148682']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043346952', 'display_name': 'Forbes D. Porter', 'orcid': 'https://orcid.org/0000-0001-9397-0046'}, 'institutions': [{'id': 'https://openalex.org/I4210144228', 'display_name': 'Eunice Kennedy Shriver National Institute of Child Health and Human Development', 'ror': 'https://ror.org/04byxyr05', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210144228']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Forbes D. Porter', 'raw_affiliation_strings': ['Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver NICHD, National Institutes of Health, Bethesda, Maryland 20892'], 'affiliations': [{'raw_affiliation_string': 'Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver NICHD, National Institutes of Health, Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I4210144228', 'https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071028184', 'display_name': 'Rohini Sidhu', 'orcid': 'https://orcid.org/0000-0003-1703-2167'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rohini Sidhu', 'raw_affiliation_strings': ['Diabetic Cardiovascular Disease Center, Washington University School of Medicine, St. Louis, Missouri 63110.'], 'affiliations': [{'raw_affiliation_string': 'Diabetic Cardiovascular Disease Center, Washington University School of Medicine, St. Louis, Missouri 63110.', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030603509', 'display_name': 'Sally Finkes', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sally Finkes', 'raw_affiliation_strings': ['Diabetic Cardiovascular Disease Center, Washington University School of Medicine, St. Louis, Missouri 63110.'], 'affiliations': [{'raw_affiliation_string': 'Diabetic Cardiovascular Disease Center, Washington University School of Medicine, St. Louis, Missouri 63110.', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103088335', 'display_name': 'Daniel S. Ory', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daniel S. Ory', 'raw_affiliation_strings': ['Diabetic Cardiovascular Disease Center, Washington University School of Medicine, St. Louis, Missouri 63110.'], 'affiliations': [{'raw_affiliation_string': 'Diabetic Cardiovascular Disease Center, Washington University School of Medicine, St. Louis, Missouri 63110.', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061998470', 'display_name': 'Juan Marugán', 'orcid': 'https://orcid.org/0000-0002-3951-7061'}, 'institutions': [{'id': 'https://openalex.org/I4210148682', 'display_name': 'National Center for Advancing Translational Sciences', 'ror': 'https://ror.org/04pw6fb54', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210148682']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Juan J. Marugan', 'raw_affiliation_strings': ['National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892'], 'affiliations': [{'raw_affiliation_string': 'National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I4210148682', 'https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112419443', 'display_name': 'Jingbo Xiao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210148682', 'display_name': 'National Center for Advancing Translational Sciences', 'ror': 'https://ror.org/04pw6fb54', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210148682']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jingbo Xiao', 'raw_affiliation_strings': ['National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892'], 'affiliations': [{'raw_affiliation_string': 'National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I4210148682', 'https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036261394', 'display_name': 'Noel Southall', 'orcid': 'https://orcid.org/0000-0003-4500-880X'}, 'institutions': [{'id': 'https://openalex.org/I4210148682', 'display_name': 'National Center for Advancing Translational Sciences', 'ror': 'https://ror.org/04pw6fb54', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210148682']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Noel Southall', 'raw_affiliation_strings': ['National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892'], 'affiliations': [{'raw_affiliation_string': 'National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I4210148682', 'https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002726308', 'display_name': 'William J. Pavan', 'orcid': 'https://orcid.org/0000-0001-8281-5120'}, 'institutions': [{'id': 'https://openalex.org/I4210090236', 'display_name': 'National Human Genome Research Institute', 'ror': 'https://ror.org/00baak391', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210090236']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'William J. Pavan', 'raw_affiliation_strings': ['Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892'], 'affiliations': [{'raw_affiliation_string': 'Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I4210090236', 'https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026435689', 'display_name': 'Cristin Davidson', 'orcid': 'https://orcid.org/0000-0002-5508-8113'}, 'institutions': [{'id': 'https://openalex.org/I2802421775', 'display_name': 'John F. Kennedy Center for the Performing Arts', 'ror': 'https://ror.org/02f7sfa33', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2802421775']}, {'id': 'https://openalex.org/I129975664', 'display_name': 'Albert Einstein College of Medicine', 'ror': 'https://ror.org/05cf8a891', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I129975664', 'https://openalex.org/I4210112371']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Cristin Davidson', 'raw_affiliation_strings': ['Sidney Weisner Laboratory of Genetic Neurological Disease, Rose F. Kennedy Center, Albert Einstein College of Medicine, Bronx, New York 10461'], 'affiliations': [{'raw_affiliation_string': 'Sidney Weisner Laboratory of Genetic Neurological Disease, Rose F. Kennedy Center, Albert Einstein College of Medicine, Bronx, New York 10461', 'institution_ids': ['https://openalex.org/I2802421775', 'https://openalex.org/I129975664']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045148387', 'display_name': 'Steven U. Walkley', 'orcid': 'https://orcid.org/0000-0003-2279-8597'}, 'institutions': [{'id': 'https://openalex.org/I129975664', 'display_name': 'Albert Einstein College of Medicine', 'ror': 'https://ror.org/05cf8a891', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I129975664', 'https://openalex.org/I4210112371']}, {'id': 'https://openalex.org/I2802421775', 'display_name': 'John F. Kennedy Center for the Performing Arts', 'ror': 'https://ror.org/02f7sfa33', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2802421775']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Steven U. Walkley', 'raw_affiliation_strings': ['Sidney Weisner Laboratory of Genetic Neurological Disease, Rose F. Kennedy Center, Albert Einstein College of Medicine, Bronx, New York 10461'], 'affiliations': [{'raw_affiliation_string': 'Sidney Weisner Laboratory of Genetic Neurological Disease, Rose F. Kennedy Center, Albert Einstein College of Medicine, Bronx, New York 10461', 'institution_ids': ['https://openalex.org/I129975664', 'https://openalex.org/I2802421775']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068951391', 'display_name': 'Alan T. Remaley', 'orcid': 'https://orcid.org/0000-0001-5839-7280'}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210106489', 'display_name': 'National Heart Lung and Blood Institute', 'ror': 'https://ror.org/012pb6c26', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210106489']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alan T. Remaley', 'raw_affiliation_strings': ['Laboratory of Lipoprotein Metabolism, NHLBI, National Institutes of Health, Bethesda, Maryland 20892'], 'affiliations': [{'raw_affiliation_string': 'Laboratory of Lipoprotein Metabolism, NHLBI, National Institutes of Health, Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I1299303238', 'https://openalex.org/I4210106489']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005541485', 'display_name': 'Ulrich Baxa', 'orcid': 'https://orcid.org/0000-0002-7263-5078'}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ulrich Baxa', 'raw_affiliation_strings': ['Electron Microscopy Laboratory, NCI, National Institutes of Health, Bethesda, Maryland 20892'], 'affiliations': [{'raw_affiliation_string': 'Electron Microscopy Laboratory, NCI, National Institutes of Health, Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101769059', 'display_name': 'Wei Sun', 'orcid': 'https://orcid.org/0000-0001-6742-1393'}, 'institutions': [{'id': 'https://openalex.org/I4210148682', 'display_name': 'National Center for Advancing Translational Sciences', 'ror': 'https://ror.org/04pw6fb54', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210148682']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wei Sun', 'raw_affiliation_strings': ['National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892'], 'affiliations': [{'raw_affiliation_string': 'National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I4210148682', 'https://openalex.org/I1299303238']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018433143', 'display_name': 'John C. McKew', 'orcid': 'https://orcid.org/0000-0003-0771-8114'}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210148682', 'display_name': 'National Center for Advancing Translational Sciences', 'ror': 'https://ror.org/04pw6fb54', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210148682']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John C. McKew', 'raw_affiliation_strings': ['National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892'], 'affiliations': [{'raw_affiliation_string': 'National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I1299303238', 'https://openalex.org/I4210148682']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044892430', 'display_name': 'Christopher P. Austin', 'orcid': 'https://orcid.org/0000-0001-7770-0708'}, 'institutions': [{'id': 'https://openalex.org/I4210148682', 'display_name': 'National Center for Advancing Translational Sciences', 'ror': 'https://ror.org/04pw6fb54', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210148682']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christopher P. Austin', 'raw_affiliation_strings': ['National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892'], 'affiliations': [{'raw_affiliation_string': 'National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I4210148682', 'https://openalex.org/I1299303238']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5035735276', 'display_name': 'Wei Zheng', 'orcid': 'https://orcid.org/0000-0003-1034-0757'}, 'institutions': [{'id': 'https://openalex.org/I4210148682', 'display_name': 'National Center for Advancing Translational Sciences', 'ror': 'https://ror.org/04pw6fb54', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210148682']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wei Zheng', 'raw_affiliation_strings': ['National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892'], 'affiliations': [{'raw_affiliation_string': 'National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892', 'institution_ids': ['https://openalex.org/I4210148682', 'https://openalex.org/I1299303238']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 10, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 7.289, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 119, 'citation_normalized_percentile': {'value': 0.999948, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '287', 'issue': '47', 'first_page': '39349', 'last_page': '39360'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10945', 'display_name': 'Lysosomal Storage Disorders Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10945', 'display_name': 'Lysosomal Storage Disorders Research', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11308', 'display_name': 'Sphingolipid Metabolism and Signaling', 'score': 0.9848, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11655', 'display_name': 'HIV-related health complications and treatments', 'score': 0.9835, 'subfield': {'id': 'https://openalex.org/subfields/2711', 'display_name': 'Emergency Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/npc1', 'display_name': 'NPC1', 'score': 0.93993986}, {'id': 'https://openalex.org/keywords/niemann–pick-disease', 'display_name': 'Niemann–Pick disease', 'score': 0.83507955}, {'id': 'https://openalex.org/keywords/lysosomal-storage-disease', 'display_name': 'Lysosomal storage disease', 'score': 0.7894343}, {'id': 'https://openalex.org/keywords/batten-disease', 'display_name': 'Batten disease', 'score': 0.4794825}, {'id': 'https://openalex.org/keywords/mannose-6-phosphate-receptor', 'display_name': 'Mannose 6-phosphate receptor', 'score': 0.45759875}, {'id': 'https://openalex.org/keywords/neuronal-ceroid-lipofuscinosis', 'display_name': 'Neuronal ceroid lipofuscinosis', 'score': 0.4436974}, {'id': 'https://openalex.org/keywords/lysosomal-storage-disorders', 'display_name': 'Lysosomal Storage Disorders', 'score': 0.4323117}], 'concepts': [{'id': 'https://openalex.org/C2778552423', 'wikidata': 'https://www.wikidata.org/wiki/Q14914279', 'display_name': 'NPC1', 'level': 4, 'score': 0.93993986}, {'id': 'https://openalex.org/C2780635549', 'wikidata': 'https://www.wikidata.org/wiki/Q2067267', 'display_name': 'Niemann–Pick disease, type C', 'level': 3, 'score': 0.87942797}, {'id': 'https://openalex.org/C2779489717', 'wikidata': 'https://www.wikidata.org/wiki/Q1419931', 'display_name': 'Niemann–Pick disease', 'level': 3, 'score': 0.83507955}, {'id': 'https://openalex.org/C2778264360', 'wikidata': 'https://www.wikidata.org/wiki/Q675010', 'display_name': 'Lysosomal storage disease', 'level': 3, 'score': 0.7894343}, {'id': 'https://openalex.org/C2780216420', 'wikidata': 'https://www.wikidata.org/wiki/Q83330', 'display_name': 'Lysosome', 'level': 3, 'score': 0.71104854}, {'id': 'https://openalex.org/C2778163477', 'wikidata': 'https://www.wikidata.org/wiki/Q43656', 'display_name': 'Cholesterol', 'level': 2, 'score': 0.4880251}, {'id': 'https://openalex.org/C2778230176', 'wikidata': 'https://www.wikidata.org/wiki/Q1753778', 'display_name': 'Batten disease', 'level': 3, 'score': 0.4794825}, {'id': 'https://openalex.org/C120694314', 'wikidata': 'https://www.wikidata.org/wiki/Q6750941', 'display_name': 'Mannose 6-phosphate receptor', 'level': 4, 'score': 0.45759875}, {'id': 'https://openalex.org/C102747710', 'wikidata': 'https://www.wikidata.org/wiki/Q824237', 'display_name': 'Endosome', 'level': 3, 'score': 0.45561275}, {'id': 'https://openalex.org/C2778650512', 'wikidata': 'https://www.wikidata.org/wiki/Q4358039', 'display_name': 'Neuronal ceroid lipofuscinosis', 'level': 3, 'score': 0.4436974}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4375463}, {'id': 'https://openalex.org/C2908579795', 'wikidata': 'https://www.wikidata.org/wiki/Q675010', 'display_name': 'Lysosomal storage disorders', 'level': 3, 'score': 0.4323117}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.39837492}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3866703}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.33444467}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.31230527}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.1526221}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.124611914}], 'mesh': [{'descriptor_ui': 'D020013', 'descriptor_name': 'Calcium Signaling', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D002784', 'descriptor_name': 'Cholesterol', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D050356', 'descriptor_name': 'Lipid Metabolism', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D052556', 'descriptor_name': 'Niemann-Pick Disease, Type C', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D024505', 'descriptor_name': 'Tocopherols', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D015223', 'descriptor_name': 'Wolman Disease', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002118', 'descriptor_name': 'Calcium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020013', 'descriptor_name': 'Calcium Signaling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002784', 'descriptor_name': 'Cholesterol', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006224', 'descriptor_name': 'Cricetinae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005089', 'descriptor_name': 'Exocytosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005089', 'descriptor_name': 'Exocytosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050356', 'descriptor_name': 'Lipid Metabolism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008247', 'descriptor_name': 'Lysosomes', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D052556', 'descriptor_name': 'Niemann-Pick Disease, Type C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052556', 'descriptor_name': 'Niemann-Pick Disease, Type C', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D024505', 'descriptor_name': 'Tocopherols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015223', 'descriptor_name': 'Wolman Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015223', 'descriptor_name': 'Wolman Disease', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m112.357707', 'pdf_url': 'http://www.jbc.org/article/S0021925820622335/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3501083', 'pdf_url': 'https://europepmc.org/articles/pmc3501083?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501083', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23035117', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m112.357707', 'pdf_url': 'http://www.jbc.org/article/S0021925820622335/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.64, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 50, 'referenced_works': ['https://openalex.org/W106241503', 'https://openalex.org/W1490169551', 'https://openalex.org/W1535285650', 'https://openalex.org/W1553107632', 'https://openalex.org/W1583024484', 'https://openalex.org/W1900790925', 'https://openalex.org/W1965722065', 'https://openalex.org/W1987054071', 'https://openalex.org/W1994519378', 'https://openalex.org/W1998249296', 'https://openalex.org/W2003003181', 'https://openalex.org/W2007718055', 'https://openalex.org/W2012619495', 'https://openalex.org/W2017214552', 'https://openalex.org/W2023567224', 'https://openalex.org/W2023707309', 'https://openalex.org/W2025395154', 'https://openalex.org/W2037307064', 'https://openalex.org/W2038238765', 'https://openalex.org/W2044869954', 'https://openalex.org/W2046407155', 'https://openalex.org/W2052009430', 'https://openalex.org/W2052385124', 'https://openalex.org/W2056228772', 'https://openalex.org/W2065408118', 'https://openalex.org/W2069188070', 'https://openalex.org/W2082011949', 'https://openalex.org/W2087839268', 'https://openalex.org/W2089085630', 'https://openalex.org/W2091234795', 'https://openalex.org/W2108492672', 'https://openalex.org/W2111482014', 'https://openalex.org/W2116290781', 'https://openalex.org/W2131627090', 'https://openalex.org/W2132617605', 'https://openalex.org/W2136116905', 'https://openalex.org/W2138786573', 'https://openalex.org/W2147612731', 'https://openalex.org/W2150206832', 'https://openalex.org/W2152311269', 'https://openalex.org/W2152828683', 'https://openalex.org/W2153824991', 'https://openalex.org/W2163583299', 'https://openalex.org/W2170106154', 'https://openalex.org/W2173535394', 'https://openalex.org/W2187911644', 'https://openalex.org/W2300552860', 'https://openalex.org/W2321740044', 'https://openalex.org/W278832569', 'https://openalex.org/W3024300525'], 'related_works': ['https://openalex.org/W3203590990', 'https://openalex.org/W3042866968', 'https://openalex.org/W3004336560', 'https://openalex.org/W2895358534', 'https://openalex.org/W2885234628', 'https://openalex.org/W2711429970', 'https://openalex.org/W2344443137', 'https://openalex.org/W2166539605', 'https://openalex.org/W2141322398', 'https://openalex.org/W2067085641'], 'abstract_inverted_index': {'Niemann-Pick': [0, 158], 'disease': [1, 7, 37, 44, 159], 'type': [2, 160, 163, 166], 'C': [3], '(NPC)': [4], 'and': [5, 55, 65, 92, 99, 115, 169], 'Wolman': [6, 43, 66, 100], 'are': [8, 58], 'two': [9], 'members': [10], 'of': [11, 14, 20, 28, 53, 62, 72, 103, 118, 128, 185, 191], 'a': [12, 69, 110, 123, 179], 'family': [13], 'storage': [15, 146, 187], 'disorders': [16], 'caused': [17], 'by': [18, 109], 'mutations': [19], 'genes': [21], 'encoding': [22], 'lysosomal': [23, 39, 83, 87, 119, 129, 145, 186], 'proteins.': [24], 'Deficiency': [25], 'in': [26, 35, 42, 46, 96, 140, 188], 'function': [27], 'either': [29], 'the': [30], 'NPC1': [31, 98], 'or': [32, 38], 'NPC2': [33], 'protein': [34], 'NPC': [36, 64], 'acid': [40], 'lipase': [41], 'results': [45], 'defective': [47], 'cellular': [48], 'cholesterol': [49, 54, 84, 90], 'trafficking.': [50], 'Lysosomal': [51], 'accumulation': [52], 'enlarged': [56], 'lysosomes': [57], 'shared': [59], 'phenotypic': [60, 70], 'characteristics': [61], 'both': [63, 97], 'cells.': [67], 'Utilizing': [68], 'screen': [71], 'an': [73], 'approved': [74], 'drug': [75], 'collection,': [76], 'we': [77, 132], 'found': [78, 134], 'that': [79, 135, 174], 'δ-tocopherol': [80, 136], 'effectively': [81], 'reduced': [82], 'accumulation,': [85, 131], 'decreased': [86], 'volume,': [88], 'increased': [89], 'efflux,': [91], 'alleviated': [93], 'pathological': [94, 138], 'phenotypes': [95, 139], 'fibroblasts.': [101], 'Reduction': [102], 'these': [104], 'abnormalities': [105], 'may': [106, 177], 'be': [107], 'mediated': [108], 'δ-tocopherol-induced': [111], 'intracellular': [112], 'Ca(2+)': [113], 'response': [114], 'subsequent': [116], 'enhancement': [117], 'exocytosis.': [120], 'Consistent': [121], 'with': [122], 'general': [124], 'mechanism': [125], 'for': [126, 183], 'reduction': [127, 184], 'lipid': [130], 'also': [133], 'reduces': [137], 'patient': [141], 'fibroblasts': [142], 'from': [143], 'other': [144], 'diseases,': [147], 'including': [148], 'NPC2,': [149], 'Batten': [150], '(ceroid': [151], 'lipofuscinosis,': [152], 'neuronal': [153], '2,': [154], 'CLN2),': [155], 'Fabry,': [156], 'Farber,': [157], 'A,': [161], 'Sanfilippo': [162], 'B': [164], '(mucopolysaccharidosis': [165], 'IIIB,': [167], 'MPSIIIB),': [168], 'Tay-Sachs.': [170], 'Our': [171], 'data': [172], 'suggest': [173], 'regulated': [175], 'exocytosis': [176], 'represent': [178], 'potential': [180], 'therapeutic': [181], 'target': [182], 'this': [189], 'class': [190], 'diseases.': [192]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2141322398', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 14}, {'year': 2019, 'cited_by_count': 10}, {'year': 2018, 'cited_by_count': 16}, {'year': 2017, 'cited_by_count': 12}, {'year': 2016, 'cited_by_count': 14}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 13}, {'year': 2013, 'cited_by_count': 18}], 'updated_date': '2024-12-24T13:43:29.914911', 'created_date': '2016-06-24'}