Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2141037581', 'doi': 'https://doi.org/10.1038/onc.2011.384', 'title': 'Molecular mechanisms of cisplatin resistance', 'display_name': 'Molecular mechanisms of cisplatin resistance', 'publication_year': 2011, 'publication_date': '2011-09-05', 'ids': {'openalex': 'https://openalex.org/W2141037581', 'doi': 'https://doi.org/10.1038/onc.2011.384', 'mag': '2141037581', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21892204'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/onc.2011.384', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S128439998', 'display_name': 'Oncogene', 'issn_l': '0950-9232', 'issn': ['0950-9232', '1476-5594'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1038/onc.2011.384', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5071827163', 'display_name': 'Lorenzo Galluzzi', 'orcid': 'https://orcid.org/0000-0003-2257-8500'}, 'institutions': [{'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'L Galluzzi', 'raw_affiliation_strings': ["INSERM, U848 'Apoptosis, Cancer and Immunity', Villejuif, France."], 'affiliations': [{'raw_affiliation_string': "INSERM, U848 'Apoptosis, Cancer and Immunity', Villejuif, France.", 'institution_ids': ['https://openalex.org/I154526488']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074355427', 'display_name': 'Laura Senovilla', 'orcid': 'https://orcid.org/0000-0001-6887-2436'}, 'institutions': [{'id': 'https://openalex.org/I102197404', 'display_name': 'Université Paris-Sud', 'ror': 'https://ror.org/028rypz17', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I102197404']}, {'id': 'https://openalex.org/I4210109573', 'display_name': 'Immunité et Cancer', 'ror': 'https://ror.org/01zefvs55', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I4210109573', 'https://openalex.org/I80043']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I2801843802', 'display_name': 'Institut Gustave Roussy', 'ror': 'https://ror.org/0321g0743', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I2801843802']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'L Senovilla', 'raw_affiliation_strings': ['INSERM, U848 ‘Apoptosis, Cancer and Immunity’; Villejuif France', 'Institut Gustave Roussy, Villejuif, France', 'Université Paris Sud-XI; Villejuif France'], 'affiliations': [{'raw_affiliation_string': 'Université Paris Sud-XI; Villejuif France', 'institution_ids': ['https://openalex.org/I102197404']}, {'raw_affiliation_string': 'INSERM, U848 ‘Apoptosis, Cancer and Immunity’; Villejuif France', 'institution_ids': ['https://openalex.org/I4210109573', 'https://openalex.org/I154526488']}, {'raw_affiliation_string': 'Institut Gustave Roussy, Villejuif, France', 'institution_ids': ['https://openalex.org/I2801843802']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067656240', 'display_name': 'Ilio Vitale', 'orcid': 'https://orcid.org/0000-0002-5918-1841'}, 'institutions': [{'id': 'https://openalex.org/I102197404', 'display_name': 'Université Paris-Sud', 'ror': 'https://ror.org/028rypz17', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I102197404']}, {'id': 'https://openalex.org/I4210109573', 'display_name': 'Immunité et Cancer', 'ror': 'https://ror.org/01zefvs55', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I4210109573', 'https://openalex.org/I80043']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I2801843802', 'display_name': 'Institut Gustave Roussy', 'ror': 'https://ror.org/0321g0743', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I2801843802']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'I Vitale', 'raw_affiliation_strings': ['INSERM, U848 ‘Apoptosis, Cancer and Immunity’; Villejuif France', 'Institut Gustave Roussy, Villejuif, France', 'Université Paris Sud-XI; Villejuif France'], 'affiliations': [{'raw_affiliation_string': 'Université Paris Sud-XI; Villejuif France', 'institution_ids': ['https://openalex.org/I102197404']}, {'raw_affiliation_string': 'INSERM, U848 ‘Apoptosis, Cancer and Immunity’; Villejuif France', 'institution_ids': ['https://openalex.org/I4210109573', 'https://openalex.org/I154526488']}, {'raw_affiliation_string': 'Institut Gustave Roussy, Villejuif, France', 'institution_ids': ['https://openalex.org/I2801843802']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001949379', 'display_name': 'Judith Michels', 'orcid': 'https://orcid.org/0000-0002-9640-0222'}, 'institutions': [{'id': 'https://openalex.org/I102197404', 'display_name': 'Université Paris-Sud', 'ror': 'https://ror.org/028rypz17', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I102197404']}, {'id': 'https://openalex.org/I4210109573', 'display_name': 'Immunité et Cancer', 'ror': 'https://ror.org/01zefvs55', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I4210109573', 'https://openalex.org/I80043']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I2801843802', 'display_name': 'Institut Gustave Roussy', 'ror': 'https://ror.org/0321g0743', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I2801843802']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'J Michels', 'raw_affiliation_strings': ['INSERM, U848 ‘Apoptosis, Cancer and Immunity’; Villejuif France', 'Institut Gustave Roussy, Villejuif, France', 'Université Paris Sud-XI; Villejuif France'], 'affiliations': [{'raw_affiliation_string': 'Université Paris Sud-XI; Villejuif France', 'institution_ids': ['https://openalex.org/I102197404']}, {'raw_affiliation_string': 'INSERM, U848 ‘Apoptosis, Cancer and Immunity’; Villejuif France', 'institution_ids': ['https://openalex.org/I4210109573', 'https://openalex.org/I154526488']}, {'raw_affiliation_string': 'Institut Gustave Roussy, Villejuif, France', 'institution_ids': ['https://openalex.org/I2801843802']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077808010', 'display_name': 'Isabelle Martins', 'orcid': 'https://orcid.org/0000-0003-0885-613X'}, 'institutions': [{'id': 'https://openalex.org/I102197404', 'display_name': 'Université Paris-Sud', 'ror': 'https://ror.org/028rypz17', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I102197404']}, {'id': 'https://openalex.org/I4210109573', 'display_name': 'Immunité et Cancer', 'ror': 'https://ror.org/01zefvs55', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I4210109573', 'https://openalex.org/I80043']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I2801843802', 'display_name': 'Institut Gustave Roussy', 'ror': 'https://ror.org/0321g0743', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I2801843802']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'I Martins', 'raw_affiliation_strings': ['INSERM, U848 ‘Apoptosis, Cancer and Immunity’; Villejuif France', 'Institut Gustave Roussy, Villejuif, France', 'Université Paris Sud-XI; Villejuif France'], 'affiliations': [{'raw_affiliation_string': 'Université Paris Sud-XI; Villejuif France', 'institution_ids': ['https://openalex.org/I102197404']}, {'raw_affiliation_string': 'INSERM, U848 ‘Apoptosis, Cancer and Immunity’; Villejuif France', 'institution_ids': ['https://openalex.org/I4210109573', 'https://openalex.org/I154526488']}, {'raw_affiliation_string': 'Institut Gustave Roussy, Villejuif, France', 'institution_ids': ['https://openalex.org/I2801843802']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056768522', 'display_name': 'Oliver Kepp', 'orcid': 'https://orcid.org/0000-0002-6081-9558'}, 'institutions': [{'id': 'https://openalex.org/I4210109573', 'display_name': 'Immunité et Cancer', 'ror': 'https://ror.org/01zefvs55', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I4210109573', 'https://openalex.org/I80043']}, {'id': 'https://openalex.org/I102197404', 'display_name': 'Université Paris-Sud', 'ror': 'https://ror.org/028rypz17', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I102197404']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I2801843802', 'display_name': 'Institut Gustave Roussy', 'ror': 'https://ror.org/0321g0743', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I2801843802']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'O Kepp', 'raw_affiliation_strings': ['INSERM, U848 ‘Apoptosis, Cancer and Immunity’; Villejuif France', 'Institut Gustave Roussy, Villejuif, France', 'Université Paris Sud-XI; Villejuif France'], 'affiliations': [{'raw_affiliation_string': 'INSERM, U848 ‘Apoptosis, Cancer and Immunity’; Villejuif France', 'institution_ids': ['https://openalex.org/I4210109573', 'https://openalex.org/I154526488']}, {'raw_affiliation_string': 'Université Paris Sud-XI; Villejuif France', 'institution_ids': ['https://openalex.org/I102197404']}, {'raw_affiliation_string': 'Institut Gustave Roussy, Villejuif, France', 'institution_ids': ['https://openalex.org/I2801843802']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044366070', 'display_name': 'Maria Castedo', 'orcid': 'https://orcid.org/0000-0001-6855-3451'}, 'institutions': [{'id': 'https://openalex.org/I102197404', 'display_name': 'Université Paris-Sud', 'ror': 'https://ror.org/028rypz17', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I102197404']}, {'id': 'https://openalex.org/I4210109573', 'display_name': 'Immunité et Cancer', 'ror': 'https://ror.org/01zefvs55', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I4210109573', 'https://openalex.org/I80043']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}, {'id': 'https://openalex.org/I2801843802', 'display_name': 'Institut Gustave Roussy', 'ror': 'https://ror.org/0321g0743', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I2801843802']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'M Castedo', 'raw_affiliation_strings': ['INSERM, U848 ‘Apoptosis, Cancer and Immunity’; Villejuif France', 'Institut Gustave Roussy, Villejuif, France', 'Université Paris Sud-XI; Villejuif France'], 'affiliations': [{'raw_affiliation_string': 'Université Paris Sud-XI; Villejuif France', 'institution_ids': ['https://openalex.org/I102197404']}, {'raw_affiliation_string': 'INSERM, U848 ‘Apoptosis, Cancer and Immunity’; Villejuif France', 'institution_ids': ['https://openalex.org/I4210109573', 'https://openalex.org/I154526488']}, {'raw_affiliation_string': 'Institut Gustave Roussy, Villejuif, France', 'institution_ids': ['https://openalex.org/I2801843802']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5075296559', 'display_name': 'Guido Kroemer', 'orcid': 'https://orcid.org/0000-0002-9334-4405'}, 'institutions': [{'id': 'https://openalex.org/I4210109573', 'display_name': 'Immunité et Cancer', 'ror': 'https://ror.org/01zefvs55', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I154526488', 'https://openalex.org/I4210109573', 'https://openalex.org/I80043']}, {'id': 'https://openalex.org/I154526488', 'display_name': 'Inserm', 'ror': 'https://ror.org/02vjkv261', 'country_code': 'FR', 'type': 'government', 'lineage': ['https://openalex.org/I154526488']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'G Kroemer', 'raw_affiliation_strings': ['INSERM, U848 ‘Apoptosis, Cancer and Immunity’, Villejuif, France'], 'affiliations': [{'raw_affiliation_string': 'INSERM, U848 ‘Apoptosis, Cancer and Immunity’, Villejuif, France', 'institution_ids': ['https://openalex.org/I4210109573', 'https://openalex.org/I154526488']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4390, 'currency': 'EUR', 'value_usd': 5490, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 9.787, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 2277, 'citation_normalized_percentile': {'value': 0.699569, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '31', 'issue': '15', 'first_page': '1869', 'last_page': '1883'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10123', 'display_name': 'Molecular Mechanisms of DNA Damage Response', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10123', 'display_name': 'Molecular Mechanisms of DNA Damage Response', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10163', 'display_name': 'Platinum-Based Cancer Chemotherapy', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11845', 'display_name': 'DNA Topoisomerases: Structure, Function, and Inhibition', 'score': 0.9946, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cisplatin-resistance', 'display_name': 'Cisplatin Resistance', 'score': 0.587059}], 'concepts': [{'id': 'https://openalex.org/C2778239845', 'wikidata': 'https://www.wikidata.org/wiki/Q412415', 'display_name': 'Cisplatin', 'level': 3, 'score': 0.96164775}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7301037}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.66786623}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.53939265}, {'id': 'https://openalex.org/C134935766', 'wikidata': 'https://www.wikidata.org/wiki/Q210538', 'display_name': 'DNA repair', 'level': 3, 'score': 0.46177375}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.4243216}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.32990068}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.32925123}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.32218644}, {'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.28523818}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.23768702}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.16818056}], 'mesh': [{'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018736', 'descriptor_name': 'DNA Adducts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018736', 'descriptor_name': 'DNA Adducts', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004260', 'descriptor_name': 'DNA Repair', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/onc.2011.384', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S128439998', 'display_name': 'Oncogene', 'issn_l': '0950-9232', 'issn': ['0950-9232', '1476-5594'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21892204', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/onc.2011.384', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S128439998', 'display_name': 'Oncogene', 'issn_l': '0950-9232', 'issn': ['0950-9232', '1476-5594'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.86, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 193, 'referenced_works': ['https://openalex.org/W135571340', 'https://openalex.org/W1482451012', 'https://openalex.org/W1496882207', 'https://openalex.org/W1503322288', 'https://openalex.org/W1509669696', 'https://openalex.org/W1541405335', 'https://openalex.org/W1553367038', 'https://openalex.org/W1558366281', 'https://openalex.org/W1575135190', 'https://openalex.org/W1581204894', 'https://openalex.org/W1741860215', 'https://openalex.org/W1751582566', 'https://openalex.org/W1775562748', 'https://openalex.org/W1802949207', 'https://openalex.org/W1856122700', 'https://openalex.org/W1864699017', 'https://openalex.org/W1937607074', 'https://openalex.org/W1963759331', 'https://openalex.org/W1964483580', 'https://openalex.org/W1964529737', 'https://openalex.org/W1966672378', 'https://openalex.org/W1969405789', 'https://openalex.org/W1969791922', 'https://openalex.org/W1971332741', 'https://openalex.org/W1972070154', 'https://openalex.org/W1972562299', 'https://openalex.org/W1972687365', 'https://openalex.org/W1973268287', 'https://openalex.org/W1974671082', 'https://openalex.org/W1974691766', 'https://openalex.org/W1974831163', 'https://openalex.org/W1975080796', 'https://openalex.org/W1978531032', 'https://openalex.org/W1978860052', 'https://openalex.org/W1979908884', 'https://openalex.org/W1980635047', 'https://openalex.org/W1982640212', 'https://openalex.org/W1984375205', 'https://openalex.org/W1984665941', 'https://openalex.org/W1984853900', 'https://openalex.org/W1985282657', 'https://openalex.org/W1987365971', 'https://openalex.org/W1988116079', 'https://openalex.org/W1988936558', 'https://openalex.org/W1989937700', 'https://openalex.org/W1991399842', 'https://openalex.org/W1992396964', 'https://openalex.org/W1995242599', 'https://openalex.org/W1995396230', 'https://openalex.org/W1997909925', 'https://openalex.org/W2000402876', 'https://openalex.org/W2000501612', 'https://openalex.org/W2004718750', 'https://openalex.org/W2005428197', 'https://openalex.org/W2006173249', 'https://openalex.org/W2006358865', 'https://openalex.org/W2008517896', 'https://openalex.org/W2009007206', 'https://openalex.org/W2011743008', 'https://openalex.org/W2013478379', 'https://openalex.org/W2014994298', 'https://openalex.org/W2015884867', 'https://openalex.org/W2016203478', 'https://openalex.org/W2016612145', 'https://openalex.org/W2019617397', 'https://openalex.org/W2021736277', 'https://openalex.org/W2022254839', 'https://openalex.org/W2022736748', 'https://openalex.org/W2023964913', 'https://openalex.org/W2025291080', 'https://openalex.org/W2026143081', 'https://openalex.org/W2030763326', 'https://openalex.org/W2033136945', 'https://openalex.org/W2033281614', 'https://openalex.org/W2034615295', 'https://openalex.org/W2039810057', 'https://openalex.org/W2042083290', 'https://openalex.org/W2043125282', 'https://openalex.org/W2043445391', 'https://openalex.org/W2043610941', 'https://openalex.org/W2044021534', 'https://openalex.org/W2044640058', 'https://openalex.org/W2047438535', 'https://openalex.org/W2048580070', 'https://openalex.org/W2050202644', 'https://openalex.org/W2052153483', 'https://openalex.org/W2055530920', 'https://openalex.org/W2061023797', 'https://openalex.org/W2062130291', 'https://openalex.org/W2064980447', 'https://openalex.org/W2065849886', 'https://openalex.org/W2066606648', 'https://openalex.org/W2066969492', 'https://openalex.org/W2067117419', 'https://openalex.org/W2068996402', 'https://openalex.org/W2070890790', 'https://openalex.org/W2071274102', 'https://openalex.org/W2071443593', 'https://openalex.org/W2071811082', 'https://openalex.org/W2072678678', 'https://openalex.org/W2072895129', 'https://openalex.org/W2073235168', 'https://openalex.org/W2076705043', 'https://openalex.org/W2077510597', 'https://openalex.org/W2078374613', 'https://openalex.org/W2079786703', 'https://openalex.org/W2081184407', 'https://openalex.org/W2084492467', 'https://openalex.org/W2086404130', 'https://openalex.org/W2088829982', 'https://openalex.org/W2090597698', 'https://openalex.org/W2091103707', 'https://openalex.org/W2091961739', 'https://openalex.org/W2093168199', 'https://openalex.org/W2093544927', 'https://openalex.org/W2095078498', 'https://openalex.org/W2095156669', 'https://openalex.org/W2095889277', 'https://openalex.org/W2096535852', 'https://openalex.org/W2098645377', 'https://openalex.org/W2100506495', 'https://openalex.org/W2102265131', 'https://openalex.org/W2102662870', 'https://openalex.org/W2102752109', 'https://openalex.org/W2102989179', 'https://openalex.org/W2103105022', 'https://openalex.org/W2103192876', 'https://openalex.org/W2103922165', 'https://openalex.org/W2106515413', 'https://openalex.org/W2110790042', 'https://openalex.org/W2111403239', 'https://openalex.org/W2111766542', 'https://openalex.org/W2113689159', 'https://openalex.org/W2115027988', 'https://openalex.org/W2117582069', 'https://openalex.org/W2119983127', 'https://openalex.org/W2120921507', 'https://openalex.org/W2121368761', 'https://openalex.org/W2121401234', 'https://openalex.org/W2122020045', 'https://openalex.org/W2122561635', 'https://openalex.org/W2123133140', 'https://openalex.org/W2124295966', 'https://openalex.org/W2124322375', 'https://openalex.org/W2126130825', 'https://openalex.org/W2127286396', 'https://openalex.org/W2127610049', 'https://openalex.org/W2128403792', 'https://openalex.org/W2128798059', 'https://openalex.org/W2130032383', 'https://openalex.org/W2130177169', 'https://openalex.org/W2133362967', 'https://openalex.org/W2134709133', 'https://openalex.org/W2136652583', 'https://openalex.org/W2137075269', 'https://openalex.org/W2137571282', 'https://openalex.org/W2138496727', 'https://openalex.org/W2139163037', 'https://openalex.org/W2139840013', 'https://openalex.org/W2140287543', 'https://openalex.org/W2142397500', 'https://openalex.org/W2142822079', 'https://openalex.org/W2144817030', 'https://openalex.org/W2144851947', 'https://openalex.org/W2145940470', 'https://openalex.org/W2150822910', 'https://openalex.org/W2153746289', 'https://openalex.org/W2154175915', 'https://openalex.org/W2154925720', 'https://openalex.org/W2156214772', 'https://openalex.org/W2157004858', 'https://openalex.org/W2157096314', 'https://openalex.org/W2160126971', 'https://openalex.org/W2160492795', 'https://openalex.org/W2161242392', 'https://openalex.org/W2161384666', 'https://openalex.org/W2162313061', 'https://openalex.org/W2162957160', 'https://openalex.org/W2164277862', 'https://openalex.org/W2164468996', 'https://openalex.org/W2166218765', 'https://openalex.org/W2166937531', 'https://openalex.org/W2167494923', 'https://openalex.org/W2187648857', 'https://openalex.org/W22055284', 'https://openalex.org/W2222382372', 'https://openalex.org/W2271855069', 'https://openalex.org/W2316994976', 'https://openalex.org/W2414593708', 'https://openalex.org/W2417354618', 'https://openalex.org/W4236554963', 'https://openalex.org/W50240922', 'https://openalex.org/W86527326'], 'related_works': ['https://openalex.org/W3125757075', 'https://openalex.org/W2760815521', 'https://openalex.org/W2747101336', 'https://openalex.org/W2108718931', 'https://openalex.org/W2055890925', 'https://openalex.org/W2033918102', 'https://openalex.org/W2004480716', 'https://openalex.org/W1991644354', 'https://openalex.org/W1972094156', 'https://openalex.org/W1965186484'], 'abstract_inverted_index': {'Platinum-based': [0], 'drugs,': [1], 'and': [2, 26, 30, 65, 102, 166], 'in': [3, 82, 129, 183], 'particular': [4], 'cis-diamminedichloroplatinum(II)': [5], '(best': [6], 'known': [7], 'as': [8], 'cisplatin),': [9], 'are': [10], 'employed': [11], 'for': [12, 107], 'the': [13, 51, 58, 61, 66, 83, 98, 108, 136, 155, 189, 193], 'treatment': [14, 79], 'of': [15, 19, 48, 53, 60, 68, 75, 85, 111, 123, 138, 195], 'a': [16, 72, 120, 199], 'wide': [17], 'array': [18], 'solid': [20], 'malignancies,': [21], 'including': [22], 'testicular,': [23], 'ovarian,': [24], 'head': [25], 'neck,': [27], 'colorectal,': [28], 'bladder': [29], 'lung': [31], 'cancers.': [32], 'Cisplatin': [33], 'exerts': [34], 'anticancer': [35], 'effects': [36], 'via': [37], 'multiple': [38], 'mechanisms,': [39], 'yet': [40], 'its': [41], 'most': [42], 'prominent': [43], '(and': [44], 'best': [45], 'understood)': [46], 'mode': [47], 'action': [49], 'involves': [50], 'generation': [52], 'DNA': [54, 62, 141, 162], 'lesions': [55], 'followed': [56], 'by': [57, 126, 160], 'activation': [59], 'damage': [63, 163], 'response': [64], 'induction': [67], 'mitochondrial': [69], 'apoptosis.': [70], 'Despite': [71], 'consistent': [73], 'rate': [74], 'initial': [76], 'responses,': [77], 'cisplatin': [78, 139, 187], 'often': [80], 'results': [81], 'development': [84, 194], 'chemoresistance,': [86], 'leading': [87], 'to': [88, 140, 148], 'therapeutic': [89, 191], 'failure.': [90], 'An': [91], 'intense': [92], 'research': [93], 'has': [94], 'been': [95, 115], 'conducted': [96], 'during': [97], 'past': [99], '30': [100], 'years': [101], 'several': [103], 'mechanisms': [104], 'that': [105, 132, 145, 171], 'account': [106], 'cisplatin-resistant': [109], 'phenotype': [110], 'tumor': [112], 'cells': [113], 'have': [114], 'described.': [116], 'Here,': [117], 'we': [118], 'provide': [119], 'systematic': [121], 'discussion': [122], 'these': [124], 'mechanism': [125], 'classifying': [127], 'them': [128], 'alterations': [130], '(1)': [131], 'involve': [133], 'steps': [134], 'preceding': [135], 'binding': [137], '(pre-target': [142], 'resistance),': [143, 152], '(2)': [144], 'directly': [146], 'relate': [147], 'DNA-cisplatin': [149], 'adducts': [150], '(on-target': [151], '(3)': [153], 'concerning': [154], 'lethal': [156], 'signaling': [157], 'pathway(s)': [158], 'elicited': [159], 'cisplatin-mediated': [161], '(post-target': [164], 'resistance)': [165], '(4)': [167], 'affecting': [168], 'molecular': [169], 'circuitries': [170], 'do': [172], 'not': [173], 'present': [174], 'obvious': [175], 'links': [176], 'with': [177, 201], 'cisplatin-elicited': [178], 'signals': [179], '(off-target': [180], 'resistance).': [181], 'As': [182], 'some': [184], 'clinical': [185, 203], 'settings': [186], 'constitutes': [188], 'major': [190], 'option,': [192], 'chemosensitization': [196], 'strategies': [197], 'constitute': [198], 'goal': [200], 'important': [202], 'implications.': [204]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2141037581', 'counts_by_year': [{'year': 2024, 'cited_by_count': 161}, {'year': 2023, 'cited_by_count': 212}, {'year': 2022, 'cited_by_count': 258}, {'year': 2021, 'cited_by_count': 277}, {'year': 2020, 'cited_by_count': 234}, {'year': 2019, 'cited_by_count': 205}, {'year': 2018, 'cited_by_count': 166}, {'year': 2017, 'cited_by_count': 165}, {'year': 2016, 'cited_by_count': 151}, {'year': 2015, 'cited_by_count': 165}, {'year': 2014, 'cited_by_count': 144}, {'year': 2013, 'cited_by_count': 91}, {'year': 2012, 'cited_by_count': 34}], 'updated_date': '2024-09-13T06:34:44.513971', 'created_date': '2016-06-24'}