Publication Information

{'id': 'https://openalex.org/W2140862820', 'doi': 'https://doi.org/10.1128/aac.50.1.104-112.2006', 'title': 'Novel Gyrase Mutations in Quinolone-Resistant and -Hypersusceptible Clinical Isolates of <i>Mycobacterium tuberculosis</i> : Functional Analysis of Mutant Enzymes', 'display_name': 'Novel Gyrase Mutations in Quinolone-Resistant and -Hypersusceptible Clinical Isolates of <i>Mycobacterium tuberculosis</i> : Functional Analysis of Mutant Enzymes', 'publication_year': 2005, 'publication_date': '2005-12-23', 'ids': {'openalex': 'https://openalex.org/W2140862820', 'doi': 'https://doi.org/10.1128/aac.50.1.104-112.2006', 'mag': '2140862820', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16377674', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1346799'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/aac.50.1.104-112.2006', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc1346799?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5090449409', 'display_name': 'Alexandra Aubry', 'orcid': 'https://orcid.org/0000-0003-4230-4793'}, 'institutions': [{'id': 'https://openalex.org/I165862685', 'display_name': "St George's, University of London", 'ror': 'https://ror.org/040f08y74', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I165862685', 'https://openalex.org/I4401726869']}, {'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}], 'countries': ['FR', 'GB'], 'is_corresponding': False, 'raw_author_name': 'Alexandra Aubry', 'raw_affiliation_strings': ['Laboratoire de Bactériologie, Faculté de Médecine Pierre et Marie Curie, Université Paris VI, Paris, France', "Molecular Genetics Group, Molecular and Metabolic Signalling Centre, Division of Basic Medical Sciences, St. George's, University of London, London SW17 0RE, United Kingdom"], 'affiliations': [{'raw_affiliation_string': "Molecular Genetics Group, Molecular and Metabolic Signalling Centre, Division of Basic Medical Sciences, St. George's, University of London, London SW17 0RE, United Kingdom", 'institution_ids': ['https://openalex.org/I165862685']}, {'raw_affiliation_string': 'Laboratoire de Bactériologie, Faculté de Médecine Pierre et Marie Curie, Université Paris VI, Paris, France', 'institution_ids': ['https://openalex.org/I39804081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044308727', 'display_name': 'Nicolas Véziris', 'orcid': 'https://orcid.org/0000-0001-5660-6544'}, 'institutions': [{'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Nicolas Veziris', 'raw_affiliation_strings': ['Laboratoire de Bactériologie, Faculté de Médecine Pierre et Marie Curie, Université Paris VI, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire de Bactériologie, Faculté de Médecine Pierre et Marie Curie, Université Paris VI, Paris, France', 'institution_ids': ['https://openalex.org/I39804081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108222588', 'display_name': 'Emmanuelle Cambau', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Emmanuelle Cambau', 'raw_affiliation_strings': ['Laboratoire de Bactériologie, Faculté de Médecine Pierre et Marie Curie, Université Paris VI, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire de Bactériologie, Faculté de Médecine Pierre et Marie Curie, Université Paris VI, Paris, France', 'institution_ids': ['https://openalex.org/I39804081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108122528', 'display_name': 'C. Truffot-Pernot', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Chantal Truffot-Pernot', 'raw_affiliation_strings': ['Laboratoire de Bactériologie, Faculté de Médecine Pierre et Marie Curie, Université Paris VI, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire de Bactériologie, Faculté de Médecine Pierre et Marie Curie, Université Paris VI, Paris, France', 'institution_ids': ['https://openalex.org/I39804081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055642273', 'display_name': 'Vincent Jarlier', 'orcid': 'https://orcid.org/0000-0003-0957-0002'}, 'institutions': [{'id': 'https://openalex.org/I39804081', 'display_name': 'Sorbonne Université', 'ror': 'https://ror.org/02en5vm52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I39804081']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'Vincent Jarlier', 'raw_affiliation_strings': ['Laboratoire de Bactériologie, Faculté de Médecine Pierre et Marie Curie, Université Paris VI, Paris, France'], 'affiliations': [{'raw_affiliation_string': 'Laboratoire de Bactériologie, Faculté de Médecine Pierre et Marie Curie, Université Paris VI, Paris, France', 'institution_ids': ['https://openalex.org/I39804081']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5009035925', 'display_name': 'L. Mark Fisher', 'orcid': 'https://orcid.org/0000-0002-2172-3369'}, 'institutions': [{'id': 'https://openalex.org/I165862685', 'display_name': "St George's, University of London", 'ror': 'https://ror.org/040f08y74', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I165862685', 'https://openalex.org/I4401726869']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'L. Mark Fisher', 'raw_affiliation_strings': ["Molecular Genetics Group, Molecular and Metabolic Signalling Centre, Division of Basic Medical Sciences, St. George's, University of London, London SW17 0RE, United Kingdom"], 'affiliations': [{'raw_affiliation_string': "Molecular Genetics Group, Molecular and Metabolic Signalling Centre, Division of Basic Medical Sciences, St. George's, University of London, London SW17 0RE, United Kingdom", 'institution_ids': ['https://openalex.org/I165862685']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.726, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 193, 'citation_normalized_percentile': {'value': 0.927475, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '50', 'issue': '1', 'first_page': '104', 'last_page': '112'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11845', 'display_name': 'Cancer therapeutics and mechanisms', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10038', 'display_name': 'Tuberculosis Research and Epidemiology', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10147', 'display_name': 'Antibiotic Resistance in Bacteria', 'score': 0.9983, 'subfield': {'id': 'https://openalex.org/subfields/1313', 'display_name': 'Molecular Medicine'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/quinolone', 'display_name': 'Quinolone', 'score': 0.7749836}, {'id': 'https://openalex.org/keywords/topoisomerase-iv', 'display_name': 'Topoisomerase IV', 'score': 0.48606256}], 'concepts': [{'id': 'https://openalex.org/C167125095', 'wikidata': 'https://www.wikidata.org/wiki/Q70551687', 'display_name': 'DNA gyrase', 'level': 4, 'score': 0.9768043}, {'id': 'https://openalex.org/C2779922871', 'wikidata': 'https://www.wikidata.org/wiki/Q426549', 'display_name': 'Quinolone', 'level': 3, 'score': 0.7749836}, {'id': 'https://openalex.org/C2777975735', 'wikidata': 'https://www.wikidata.org/wiki/Q130971', 'display_name': 'Mycobacterium tuberculosis', 'level': 3, 'score': 0.63810575}, {'id': 'https://openalex.org/C2778049240', 'wikidata': 'https://www.wikidata.org/wiki/Q411447', 'display_name': 'Ofloxacin', 'level': 4, 'score': 0.6285533}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.59086084}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.57909894}, {'id': 'https://openalex.org/C89423630', 'wikidata': 'https://www.wikidata.org/wiki/Q7193', 'display_name': 'Microbiology', 'level': 1, 'score': 0.5446706}, {'id': 'https://openalex.org/C2777112418', 'wikidata': 'https://www.wikidata.org/wiki/Q7824976', 'display_name': 'Topoisomerase IV', 'level': 5, 'score': 0.48606256}, {'id': 'https://openalex.org/C3019249092', 'wikidata': 'https://www.wikidata.org/wiki/Q274493', 'display_name': 'Antibacterial agent', 'level': 3, 'score': 0.4858372}, {'id': 'https://openalex.org/C547475151', 'wikidata': 'https://www.wikidata.org/wiki/Q25419', 'display_name': 'Escherichia coli', 'level': 3, 'score': 0.38254887}, {'id': 'https://openalex.org/C2781069245', 'wikidata': 'https://www.wikidata.org/wiki/Q12204', 'display_name': 'Tuberculosis', 'level': 2, 'score': 0.2530259}, {'id': 'https://openalex.org/C2778512257', 'wikidata': 'https://www.wikidata.org/wiki/Q256602', 'display_name': 'Ciprofloxacin', 'level': 3, 'score': 0.1832124}, {'id': 'https://openalex.org/C501593827', 'wikidata': 'https://www.wikidata.org/wiki/Q12187', 'display_name': 'Antibiotics', 'level': 2, 'score': 0.18186763}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.15871277}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.11809456}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.07971597}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000995', 'descriptor_name': 'Antitubercular Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D027081', 'descriptor_name': 'DNA Gyrase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D024881', 'descriptor_name': 'Drug Resistance, Bacterial', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009169', 'descriptor_name': 'Mycobacterium tuberculosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000995', 'descriptor_name': 'Antitubercular Agents', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D000995', 'descriptor_name': 'Antitubercular Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D027081', 'descriptor_name': 'DNA Gyrase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D027081', 'descriptor_name': 'DNA Gyrase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024881', 'descriptor_name': 'Drug Resistance, Bacterial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008826', 'descriptor_name': 'Microbial Sensitivity Tests', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009169', 'descriptor_name': 'Mycobacterium tuberculosis', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D009169', 'descriptor_name': 'Mycobacterium tuberculosis', 'qualifier_ui': 'Q000302', 'qualifier_name': 'isolation & purification', 'is_major_topic': False}, {'descriptor_ui': 'D009169', 'descriptor_name': 'Mycobacterium tuberculosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/aac.50.1.104-112.2006', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S47215897', 'display_name': 'Antimicrobial Agents and Chemotherapy', 'issn_l': '0066-4804', 'issn': ['0066-4804', '1070-6283', '1098-6596'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320263', 'host_organization_name': 'American Society for Microbiology', 'host_organization_lineage': ['https://openalex.org/P4310320263'], 'host_organization_lineage_names': ['American Society for Microbiology'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1346799', 'pdf_url': 'https://europepmc.org/articles/pmc1346799?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1346799', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16377674', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1346799', 'pdf_url': 'https://europepmc.org/articles/pmc1346799?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.82}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 37, 'referenced_works': ['https://openalex.org/W1811040502', 'https://openalex.org/W1966126698', 'https://openalex.org/W1968593986', 'https://openalex.org/W1970972367', 'https://openalex.org/W1972642772', 'https://openalex.org/W1990591017', 'https://openalex.org/W1996007131', 'https://openalex.org/W1999422888', 'https://openalex.org/W2001243940', 'https://openalex.org/W2093527907', 'https://openalex.org/W2099090001', 'https://openalex.org/W2102022526', 'https://openalex.org/W2103017729', 'https://openalex.org/W2107640779', 'https://openalex.org/W2107861076', 'https://openalex.org/W2116940411', 'https://openalex.org/W2120683593', 'https://openalex.org/W2121082250', 'https://openalex.org/W2121649640', 'https://openalex.org/W2126326498', 'https://openalex.org/W2127776703', 'https://openalex.org/W2129759335', 'https://openalex.org/W2132600317', 'https://openalex.org/W2134535764', 'https://openalex.org/W2136510992', 'https://openalex.org/W2152634568', 'https://openalex.org/W2154806021', 'https://openalex.org/W2155360762', 'https://openalex.org/W2156233609', 'https://openalex.org/W2158023121', 'https://openalex.org/W2163169974', 'https://openalex.org/W2165738430', 'https://openalex.org/W2167862584', 'https://openalex.org/W2198784517', 'https://openalex.org/W2318229153', 'https://openalex.org/W2402326220', 'https://openalex.org/W2418210342'], 'related_works': ['https://openalex.org/W4205683657', 'https://openalex.org/W3039257693', 'https://openalex.org/W2802675021', 'https://openalex.org/W2163957087', 'https://openalex.org/W2152096232', 'https://openalex.org/W2123854966', 'https://openalex.org/W2101147359', 'https://openalex.org/W2088858993', 'https://openalex.org/W2072890859', 'https://openalex.org/W2039556608'], 'abstract_inverted_index': {'Mutations': [0], 'in': [1, 13, 22, 38, 62, 112, 255], 'the': [2, 23, 39, 42, 56, 72, 183, 186, 191, 216, 239, 242, 246], 'DNA': [3, 144], 'gyrase': [4, 124, 156, 206], 'GyrA2GyrB2': [5], 'complex': [6], 'are': [7, 18], 'associated': [8, 47, 78], 'with': [9, 48, 79], 'resistance': [10, 50, 60, 254], 'to': [11, 55, 97, 116, 120, 169, 215, 235], 'quinolones': [12], 'Mycobacterium': [14], 'tuberculosis.': [15, 257], 'As': [16], 'fluoroquinolones': [17], 'being': [19], 'used': [20, 119], 'increasingly': [21], 'treatment': [24], 'of': [25, 33, 89, 218, 251], 'tuberculosis,': [26], 'we': [27, 69], 'characterized': [28], 'several': [29, 83], 'multidrug-resistant': [30], 'clinical': [31], 'isolates': [32, 84], 'M.': [34, 99, 256], 'tuberculosis': [35, 100], 'carrying': [36], 'mutations': [37, 61, 230], 'genes': [40], 'encoding': [41], 'GyrA': [43, 101, 159, 209], 'or': [44, 51, 211], 'GyrB': [45, 73, 103, 165, 192], 'subunits': [46, 104], 'quinolone': [49, 59, 170, 200], 'hypersusceptibility.': [52], 'In': [53, 203], 'addition': [54], 'reported': [57], 'putative': [58], 'GyrA,': [63], 'i.e.,': [64], 'A90V,': [65, 160], 'D94G,': [66, 161], 'and': [67, 92, 102, 108, 118, 134, 142, 153, 162, 164, 173, 188, 232, 253], 'D94H,': [68], 'found': [70], 'that': [71, 223], 'N510D': [74, 166], 'mutation': [75], 'was': [76, 224], 'also': [77], 'ofloxacin': [80], 'resistance.': [81], 'Surprisingly,': [82], 'bearing': [85, 158, 208, 228], 'a': [86, 199], 'novel': [87], 'combination': [88], 'gyrA': [90, 133], 'T80A': [91, 210], 'A90G': [93, 212], 'changes': [94], 'were': [95, 110, 128, 146, 167, 194, 213], 'hypersusceptible': [96, 214], 'ofloxacin.': [98], '(wild': [105], 'type': [106], '[WT]': [107], 'mutants)': [109], 'overexpressed': [111], 'Escherichia': [113], 'coli,': [114], 'purified': [115], 'homogeneity,': [117], 'reconstitute': [121], 'highly': [122], 'active': [123], 'complexes.': [125], 'Mutant': [126, 155], 'proteins': [127], 'produced': [129], 'similarly': [130], 'from': [131], 'engineered': [132], 'gyrB': [135], 'alleles': [136], 'by': [137], 'mutagenesis.': [138], 'MICs,': [139], 'enzyme': [140], 'inhibition,': [141], 'drug-induced': [143], 'cleavage': [145, 201], 'determined': [147], 'for': [148, 185, 226, 241], 'moxifloxacin,': [149], 'gatifloxacin,': [150], 'ofloxacin,': [151], 'levofloxacin,': [152], 'enoxacin.': [154], 'complexes': [157, 207, 227], 'D94H': [163], 'resistant': [168], 'inhibition': [171], '(MICs': [172, 231], '50%': [174], 'inhibitory': [175], 'concentrations': [176, 184], '[IC50s]': [177], 'at': [178], 'least': [179], '3.5-fold': [180], 'higher': [181], 'than': [182, 238], 'WT),': [187], 'all,': [189], 'except': [190], 'mutant,': [193], 'less': [195], 'efficiently': [196], 'trapped': [197], 'as': [198], 'complex.': [202], 'marked': [204], 'contrast,': [205], 'action': [217], 'many': [219], 'quinolones,': [220], 'an': [221], 'effect': [222], 'reinforced': [225], 'both': [229], 'IC50s': [233], 'up': [234], '14-fold': [236], 'lower': [237], 'values': [240], 'WT).': [243], 'This': [244], 'is': [245], 'first': [247], 'detailed': [248], 'enzymatic': [249], 'analysis': [250], 'hypersusceptibility': [252]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2140862820', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 12}, {'year': 2016, 'cited_by_count': 10}, {'year': 2015, 'cited_by_count': 16}, {'year': 2014, 'cited_by_count': 15}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 19}], 'updated_date': '2024-12-13T08:52:35.669084', 'created_date': '2016-06-24'}