Publication Information

{'id': 'https://openalex.org/W2140793388', 'doi': 'https://doi.org/10.1634/theoncologist.2010-0260', 'title': 'Part 3: Pharmacogenetic Variability in Phase II Anticancer Drug Metabolism', 'display_name': 'Part 3: Pharmacogenetic Variability in Phase II Anticancer Drug Metabolism', 'publication_year': 2011, 'publication_date': '2011-06-09', 'ids': {'openalex': 'https://openalex.org/W2140793388', 'doi': 'https://doi.org/10.1634/theoncologist.2010-0260', 'mag': '2140793388', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21659608', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3228134'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1634/theoncologist.2010-0260', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S15523509', 'display_name': 'The Oncologist', 'issn_l': '1083-7159', 'issn': ['1083-7159', '1549-490X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316295', 'host_organization_name': 'AlphaMed Press', 'host_organization_lineage': ['https://openalex.org/P4310316295'], 'host_organization_lineage_names': ['AlphaMed Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc3228134?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5085647012', 'display_name': 'Maarten J. Deenen', 'orcid': 'https://orcid.org/0000-0002-4389-6420'}, 'institutions': [{'id': 'https://openalex.org/I4210111138', 'display_name': 'Oncode Institute', 'ror': 'https://ror.org/01n92vv28', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I4210111138']}, {'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Maarten J. Deenen', 'raw_affiliation_strings': ['Department of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands', 'a Division of Clinical Pharmacology, Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'a Division of Clinical Pharmacology, Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I4210111138', 'https://openalex.org/I2898336195']}, {'raw_affiliation_string': 'Department of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I2898336195']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017478217', 'display_name': 'Annemieke Cats', 'orcid': 'https://orcid.org/0000-0001-6509-9804'}, 'institutions': [{'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Annemieke Cats', 'raw_affiliation_strings': ['cDepartment of Gastroenterology and Hepatology, The Netherlands Cancer Institute, Amsterdam, The Netherlands;'], 'affiliations': [{'raw_affiliation_string': 'cDepartment of Gastroenterology and Hepatology, The Netherlands Cancer Institute, Amsterdam, The Netherlands;', 'institution_ids': ['https://openalex.org/I2898336195']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062227574', 'display_name': 'Jos H. Beijnen', 'orcid': 'https://orcid.org/0000-0003-0118-561X'}, 'institutions': [{'id': 'https://openalex.org/I193662353', 'display_name': 'Utrecht University', 'ror': 'https://ror.org/04pp8hn57', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I193662353']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Jos H. Beijnen', 'raw_affiliation_strings': ['e Faculty of Science, Department of Pharmaceutical Sciences, Section of Biomedical Analysis, Division of Drug Toxicology, Utrecht University, Utrecht, The Netherlands', 'eFaculty of Science, Department of Pharmaceutical Sciences, Section of Biomedical Analysis, Division of Drug Toxicology, Utrecht University, Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'eFaculty of Science, Department of Pharmaceutical Sciences, Section of Biomedical Analysis, Division of Drug Toxicology, Utrecht University, Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I193662353']}, {'raw_affiliation_string': 'e Faculty of Science, Department of Pharmaceutical Sciences, Section of Biomedical Analysis, Division of Drug Toxicology, Utrecht University, Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I193662353']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5000418012', 'display_name': 'Jan H.M. Schellens', 'orcid': 'https://orcid.org/0000-0001-6832-1976'}, 'institutions': [{'id': 'https://openalex.org/I2898336195', 'display_name': 'The Netherlands Cancer Institute', 'ror': 'https://ror.org/03xqtf034', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2898336195']}, {'id': 'https://openalex.org/I193662353', 'display_name': 'Utrecht University', 'ror': 'https://ror.org/04pp8hn57', 'country_code': 'NL', 'type': 'education', 'lineage': ['https://openalex.org/I193662353']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'Jan H.M. Schellens', 'raw_affiliation_strings': ['b Department of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands', 'e Faculty of Science, Department of Pharmaceutical Sciences, Section of Biomedical Analysis, Division of Drug Toxicology, Utrecht University, Utrecht, The Netherlands', 'eFaculty of Science, Department of Pharmaceutical Sciences, Section of Biomedical Analysis, Division of Drug Toxicology, Utrecht University, Utrecht, The Netherlands'], 'affiliations': [{'raw_affiliation_string': 'b Department of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands', 'institution_ids': ['https://openalex.org/I2898336195']}, {'raw_affiliation_string': 'e Faculty of Science, Department of Pharmaceutical Sciences, Section of Biomedical Analysis, Division of Drug Toxicology, Utrecht University, Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I193662353']}, {'raw_affiliation_string': 'eFaculty of Science, Department of Pharmaceutical Sciences, Section of Biomedical Analysis, Division of Drug Toxicology, Utrecht University, Utrecht, The Netherlands', 'institution_ids': ['https://openalex.org/I193662353']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3494, 'currency': 'USD', 'value_usd': 3494, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.584, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 27, 'citation_normalized_percentile': {'value': 0.415282, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '16', 'issue': '7', 'first_page': '992', 'last_page': '1005'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10375', 'display_name': 'Pharmacogenetics and Drug Metabolism', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10375', 'display_name': 'Pharmacogenetics and Drug Metabolism', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/3004', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/30', 'display_name': 'Pharmacology, Toxicology and Pharmaceutics'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12187', 'display_name': 'Glutathione Transferases and Polymorphisms', 'score': 0.9992, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/genetic-variability', 'display_name': 'Genetic Variability', 'score': 0.5182297}, {'id': 'https://openalex.org/keywords/gstp1', 'display_name': 'GSTP1', 'score': 0.45807597}, {'id': 'https://openalex.org/keywords/pharmacogenomics', 'display_name': 'Pharmacogenomics', 'score': 0.4505787}, {'id': 'https://openalex.org/keywords/pharmacodynamics', 'display_name': 'Pharmacodynamics', 'score': 0.43799064}, {'id': 'https://openalex.org/keywords/drug-response', 'display_name': 'Drug response', 'score': 0.42805338}, {'id': 'https://openalex.org/keywords/drug-development', 'display_name': 'Drug Development', 'score': 0.42530286}, {'id': 'https://openalex.org/keywords/pharmacotherapy', 'display_name': 'Pharmacotherapy', 'score': 0.41274768}], 'concepts': [{'id': 'https://openalex.org/C55775858', 'wikidata': 'https://www.wikidata.org/wiki/Q1152227', 'display_name': 'Pharmacogenetics', 'level': 4, 'score': 0.89217293}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.73749065}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.72485864}, {'id': 'https://openalex.org/C89311334', 'wikidata': 'https://www.wikidata.org/wiki/Q1124842', 'display_name': 'Drug metabolism', 'level': 3, 'score': 0.6713197}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.5829778}, {'id': 'https://openalex.org/C172777353', 'wikidata': 'https://www.wikidata.org/wiki/Q1374271', 'display_name': 'Genetic variability', 'level': 4, 'score': 0.5182297}, {'id': 'https://openalex.org/C2780122483', 'wikidata': 'https://www.wikidata.org/wiki/Q18026593', 'display_name': 'GSTP1', 'level': 4, 'score': 0.45807597}, {'id': 'https://openalex.org/C170734499', 'wikidata': 'https://www.wikidata.org/wiki/Q1152227', 'display_name': 'Pharmacogenomics', 'level': 2, 'score': 0.4505787}, {'id': 'https://openalex.org/C111113717', 'wikidata': 'https://www.wikidata.org/wiki/Q725307', 'display_name': 'Pharmacodynamics', 'level': 3, 'score': 0.43799064}, {'id': 'https://openalex.org/C2994119904', 'wikidata': 'https://www.wikidata.org/wiki/Q1251001', 'display_name': 'Drug response', 'level': 3, 'score': 0.42805338}, {'id': 'https://openalex.org/C64903051', 'wikidata': 'https://www.wikidata.org/wiki/Q2198549', 'display_name': 'Drug development', 'level': 3, 'score': 0.42530286}, {'id': 'https://openalex.org/C500440147', 'wikidata': 'https://www.wikidata.org/wiki/Q701216', 'display_name': 'Pharmacotherapy', 'level': 2, 'score': 0.41274768}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.37646216}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.326788}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.32049203}, {'id': 'https://openalex.org/C135763542', 'wikidata': 'https://www.wikidata.org/wiki/Q106016', 'display_name': 'Genotype', 'level': 3, 'score': 0.3159367}, {'id': 'https://openalex.org/C112705442', 'wikidata': 'https://www.wikidata.org/wiki/Q323936', 'display_name': 'Pharmacokinetics', 'level': 2, 'score': 0.28191268}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.24695575}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.24287283}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.23287413}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000493', 'qualifier_name': 'pharmacokinetics', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D010597', 'descriptor_name': 'Pharmacogenetics', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014644', 'descriptor_name': 'Genetic Variation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D010597', 'descriptor_name': 'Pharmacogenetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011110', 'descriptor_name': 'Polymorphism, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1634/theoncologist.2010-0260', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S15523509', 'display_name': 'The Oncologist', 'issn_l': '1083-7159', 'issn': ['1083-7159', '1549-490X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316295', 'host_organization_name': 'AlphaMed Press', 'host_organization_lineage': ['https://openalex.org/P4310316295'], 'host_organization_lineage_names': ['AlphaMed Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3228134', 'pdf_url': 'https://europepmc.org/articles/pmc3228134?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3228134', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21659608', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3228134', 'pdf_url': 'https://europepmc.org/articles/pmc3228134?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.46, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 114, 'referenced_works': ['https://openalex.org/W1252407659', 'https://openalex.org/W1509637701', 'https://openalex.org/W1574225715', 'https://openalex.org/W1594148627', 'https://openalex.org/W1631027698', 'https://openalex.org/W1750764013', 'https://openalex.org/W1850914599', 'https://openalex.org/W1964947822', 'https://openalex.org/W1967103850', 'https://openalex.org/W1967490229', 'https://openalex.org/W1968004589', 'https://openalex.org/W1969556302', 'https://openalex.org/W1969809385', 'https://openalex.org/W1972248724', 'https://openalex.org/W1972773868', 'https://openalex.org/W1974292630', 'https://openalex.org/W1976468768', 'https://openalex.org/W1978594041', 'https://openalex.org/W1978999706', 'https://openalex.org/W1984169395', 'https://openalex.org/W1984641899', 'https://openalex.org/W1989868349', 'https://openalex.org/W1990665707', 'https://openalex.org/W1990743262', 'https://openalex.org/W1991736137', 'https://openalex.org/W1992918749', 'https://openalex.org/W1994542058', 'https://openalex.org/W1995584424', 'https://openalex.org/W1996409190', 'https://openalex.org/W2003965848', 'https://openalex.org/W2007263773', 'https://openalex.org/W2009536846', 'https://openalex.org/W2011607101', 'https://openalex.org/W2015092588', 'https://openalex.org/W2016329982', 'https://openalex.org/W2016756549', 'https://openalex.org/W2017060960', 'https://openalex.org/W2018522063', 'https://openalex.org/W2020205310', 'https://openalex.org/W2021223798', 'https://openalex.org/W2027183498', 'https://openalex.org/W2027950584', 'https://openalex.org/W2031436799', 'https://openalex.org/W2032749099', 'https://openalex.org/W2033674020', 'https://openalex.org/W2035336252', 'https://openalex.org/W2036706547', 'https://openalex.org/W2038750466', 'https://openalex.org/W2039986747', 'https://openalex.org/W2042143199', 'https://openalex.org/W2048327703', 'https://openalex.org/W2050475316', 'https://openalex.org/W2052447033', 'https://openalex.org/W2055257627', 'https://openalex.org/W2057230334', 'https://openalex.org/W2062101898', 'https://openalex.org/W2063919832', 'https://openalex.org/W2065676027', 'https://openalex.org/W2065829703', 'https://openalex.org/W2069546278', 'https://openalex.org/W2073070205', 'https://openalex.org/W2078145905', 'https://openalex.org/W2082459431', 'https://openalex.org/W2084140931', 'https://openalex.org/W2089720722', 'https://openalex.org/W2093380647', 'https://openalex.org/W2094499171', 'https://openalex.org/W2095027842', 'https://openalex.org/W2095822339', 'https://openalex.org/W2096342039', 'https://openalex.org/W2103392752', 'https://openalex.org/W2103726865', 'https://openalex.org/W2104477572', 'https://openalex.org/W2104637985', 'https://openalex.org/W2105670618', 'https://openalex.org/W2106159140', 'https://openalex.org/W2107262592', 'https://openalex.org/W2113393299', 'https://openalex.org/W2116181319', 'https://openalex.org/W2118170001', 'https://openalex.org/W2118385151', 'https://openalex.org/W2119347977', 'https://openalex.org/W2121503597', 'https://openalex.org/W2121592758', 'https://openalex.org/W2123683190', 'https://openalex.org/W2127449669', 'https://openalex.org/W2127532818', 'https://openalex.org/W2135506468', 'https://openalex.org/W2139458933', 'https://openalex.org/W2139687160', 'https://openalex.org/W2142572653', 'https://openalex.org/W2143755247', 'https://openalex.org/W2144154516', 'https://openalex.org/W2144233828', 'https://openalex.org/W2145688747', 'https://openalex.org/W2149246244', 'https://openalex.org/W2149356694', 'https://openalex.org/W2150914452', 'https://openalex.org/W2151158169', 'https://openalex.org/W2152992217', 'https://openalex.org/W2153591132', 'https://openalex.org/W2156596704', 'https://openalex.org/W2156950528', 'https://openalex.org/W2160234875', 'https://openalex.org/W2161069288', 'https://openalex.org/W2162507937', 'https://openalex.org/W2162784517', 'https://openalex.org/W2165106918', 'https://openalex.org/W2167501156', 'https://openalex.org/W2168693396', 'https://openalex.org/W2295706507', 'https://openalex.org/W2322536880', 'https://openalex.org/W2335253526', 'https://openalex.org/W2419122952'], 'related_works': ['https://openalex.org/W4361242895', 'https://openalex.org/W4307187643', 'https://openalex.org/W2462959210', 'https://openalex.org/W2327821609', 'https://openalex.org/W2053705419', 'https://openalex.org/W2036094388', 'https://openalex.org/W1967016477', 'https://openalex.org/W1559085367', 'https://openalex.org/W1546831097', 'https://openalex.org/W1502803161'], 'abstract_inverted_index': {'Abstract': [0], 'Learning': [1], 'Objectives': [2], 'After': [3], 'completing': [4], 'this': [5], 'course,': [6], 'the': [7, 37, 99, 128, 157, 197, 222, 228, 240], 'reader': [8], 'will': [9], 'be': [10, 142], 'able': [11], 'to:': [12], 'Identify': [13], 'genetic': [14, 57, 134, 153, 204, 225], 'variants': [15, 42], 'of': [16, 40, 64, 114, 161, 187, 199, 224], 'glutathione': [17], 'S-transferase': [18], 'and': [19, 35, 116, 118, 159, 179, 218, 220], 'uridine': [20, 213], 'diphosphoglucuronosyl': [21, 214], 'transferase': [22], 'that': [23, 59, 96, 145, 169], 'have': [24, 56, 138], 'been': [25, 139], 'shown': [26], 'to': [27, 45, 84, 91, 102, 141, 147], 'affect': [28, 60, 98, 156], 'clinical': [29], 'outcomes': [30], 'in': [31, 51, 88, 133, 149, 174, 196, 206], 'patients': [32, 52, 137], 'with': [33, 43, 53], 'cancer': [34, 54], 'describe': [36], 'general': [38], 'effects': [39, 223], 'these': [41, 122, 231], 'respect': [44], 'standard': [46], 'treatment.Describe': [47], 'potential': [48], 'treatment': [49], 'considerations': [50], 'who': [55], 'polymorphisms': [58], 'Phase': [61], 'II': [62, 208], 'metabolism': [63], 'anticancer': [65, 92, 234, 246], 'drugs.': [66], 'CME': [67], 'This': [68, 193], 'article': [69], 'is': [70, 165, 170, 201], 'available': [71], 'for': [72, 172, 244], 'continuing': [73], 'medical': [74], 'education': [75], 'credit': [76], 'at': [77], 'CME.TheOncologist.com': [78], 'Equivalent': [79], 'drug': [80, 89, 104, 150, 175, 177, 181, 235], 'doses': [81], 'may': [82, 97, 155], 'lead': [83], 'wide': [85], 'interpatient': [86, 130], 'variability': [87, 173, 205], 'response': [90, 101], 'therapy.': [93], 'Known': [94], 'determinants': [95], 'pharmacological': [100], 'a': [103, 166, 185], 'are,': [105], 'among': [106, 136], 'others,': [107], 'nongenetic': [108], 'factors,': [109], 'including': [110], 'age,': [111], 'gender,': [112], 'use': [113], 'comedication,': [115], 'liver': [117], 'renal': [119], 'function.': [120], 'Nonetheless,': [121], 'covariates': [123], 'do': [124], 'not': [125], 'explain': [126], 'all': [127], 'observed': [129], 'variability.': [131, 192], 'Differences': [132], 'constitution': [135], 'identified': [140], 'important': [143], 'factors': [144], 'contribute': [146], 'differences': [148], 'response.': [151], 'Because': [152], 'polymorphism': [154, 226], 'expression': [158], 'activity': [160], 'proteins': [162], 'encoded,': [163], 'it': [164], 'key': [167], 'covariate': [168], 'responsible': [171], 'metabolism,': [176], 'transport,': [178], 'pharmacodynamic': [180], 'effects.': [182], 'We': [183], 'present': [184], 'series': [186, 198], 'four': [188], 'reviews': [189, 200], 'about': [190], 'pharmacogenetic': [191], 'third': [194], 'part': [195], 'focused': [202], 'on': [203, 233, 239], 'phase': [207], 'drug-metabolizing': [209], 'enzymes': [210, 232], '(glutathione': [211], 'S-transferases,': [212], 'transferases,': [215], 'methyltransferases,': [216], 'sulfotransferases,': [217], 'N-acetyltransferases)': [219], 'discusses': [221], 'within': [227], 'genes': [229], 'encoding': [230], 'therapy': [236, 247], 'outcome.': [237], 'Based': [238], 'literature': [241], 'reviewed,': [242], 'opportunities': [243], 'patient-tailored': [245], 'are': [248], 'proposed.': [249]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2140793388', 'counts_by_year': [{'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 5}, {'year': 2012, 'cited_by_count': 1}], 'updated_date': '2024-12-15T11:13:23.280224', 'created_date': '2016-06-24'}