Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2140647342', 'doi': 'https://doi.org/10.4269/ajtmh.13-0328', 'title': 'Investigation of the in vitro Gender-Specific Partitioning of Mefloquine in Malarial Infected Red Blood Cells and Plasma', 'display_name': 'Investigation of the in vitro Gender-Specific Partitioning of Mefloquine in Malarial Infected Red Blood Cells and Plasma', 'publication_year': 2013, 'publication_date': '2013-09-04', 'ids': {'openalex': 'https://openalex.org/W2140647342', 'doi': 'https://doi.org/10.4269/ajtmh.13-0328', 'mag': '2140647342', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24002481', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3795105'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4269/ajtmh.13-0328', 'pdf_url': 'http://www.ajtmh.org/deliver/fulltext/14761645/89/4/737.pdf?itemId=%2Fcontent%2Fjournals%2F10.4269%2Fajtmh.13-0328&mimeType=pdf&containerItemId=content/journals/14761645', 'source': {'id': 'https://openalex.org/S100045985', 'display_name': 'American Journal of Tropical Medicine and Hygiene', 'issn_l': '0002-9637', 'issn': ['0002-9637', '1476-1645'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315658', 'host_organization_name': 'American Society of Tropical Medicine and Hygiene', 'host_organization_lineage': ['https://openalex.org/P4310315658'], 'host_organization_lineage_names': ['American Society of Tropical Medicine and Hygiene'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'http://www.ajtmh.org/deliver/fulltext/14761645/89/4/737.pdf?itemId=%2Fcontent%2Fjournals%2F10.4269%2Fajtmh.13-0328&mimeType=pdf&containerItemId=content/journals/14761645', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5036292474', 'display_name': 'Nongluk Seethorn', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I108108428', 'display_name': 'Thammasat University', 'ror': 'https://ror.org/002yp7f20', 'country_code': 'TH', 'type': 'education', 'lineage': ['https://openalex.org/I108108428']}], 'countries': ['TH'], 'is_corresponding': False, 'raw_author_name': 'Nongluk Seethorn', 'raw_affiliation_strings': ['Chulabhorn International College of Medicine, Thammasat University (Rangsit Campus), Pathumthani, Thailand'], 'affiliations': [{'raw_affiliation_string': 'Chulabhorn International College of Medicine, Thammasat University (Rangsit Campus), Pathumthani, Thailand', 'institution_ids': ['https://openalex.org/I108108428']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111904885', 'display_name': 'Walther H. Wernsdorfer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I76134821', 'display_name': 'Medical University of Vienna', 'ror': 'https://ror.org/05n3x4p02', 'country_code': 'AT', 'type': 'education', 'lineage': ['https://openalex.org/I76134821']}], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Walther H. Wernsdorfer', 'raw_affiliation_strings': ['Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Austria'], 'affiliations': [{'raw_affiliation_string': 'Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Austria', 'institution_ids': ['https://openalex.org/I76134821']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065968307', 'display_name': 'Harald Noedl', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I43777268', 'display_name': 'Nagasaki University', 'ror': 'https://ror.org/058h74p94', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I43777268']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Harald Noedl', 'raw_affiliation_strings': ['Department of Clinical Product Development Institute of Tropical Medicine, Nagasaki University Nagasaki Japan'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Product Development Institute of Tropical Medicine, Nagasaki University Nagasaki Japan', 'institution_ids': ['https://openalex.org/I43777268']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5045836221', 'display_name': 'Juntra Karbwang', 'orcid': 'https://orcid.org/0000-0003-2107-7173'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Juntra Karbwang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5002736566', 'display_name': 'Kesara Na‐Bangchang', 'orcid': 'https://orcid.org/0000-0001-6389-0897'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Kesara Na-Bangchang', 'raw_affiliation_strings': [], 'affiliations': []}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.644, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.657903, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 72, 'max': 76}, 'biblio': {'volume': '89', 'issue': '4', 'first_page': '737', 'last_page': '741'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12229', 'display_name': 'Pharmacological Effects and Toxicity Studies', 'score': 0.9948, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10993', 'display_name': 'Complement system in diseases', 'score': 0.9938, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/clone', 'display_name': 'clone (Java method)', 'score': 0.5457787}], 'concepts': [{'id': 'https://openalex.org/C2777199930', 'wikidata': 'https://www.wikidata.org/wiki/Q736270', 'display_name': 'Mefloquine', 'level': 4, 'score': 0.9966986}, {'id': 'https://openalex.org/C2778048844', 'wikidata': 'https://www.wikidata.org/wiki/Q12156', 'display_name': 'Malaria', 'level': 2, 'score': 0.7034856}, {'id': 'https://openalex.org/C2778371730', 'wikidata': 'https://www.wikidata.org/wiki/Q311383', 'display_name': 'Plasmodium falciparum', 'level': 3, 'score': 0.6603743}, {'id': 'https://openalex.org/C81089528', 'wikidata': 'https://www.wikidata.org/wiki/Q5134986', 'display_name': 'clone (Java method)', 'level': 3, 'score': 0.5457787}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.50473773}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.5030498}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.49268228}, {'id': 'https://openalex.org/C2776557347', 'wikidata': 'https://www.wikidata.org/wiki/Q37187', 'display_name': 'Red blood cell', 'level': 2, 'score': 0.48780468}, {'id': 'https://openalex.org/C42407357', 'wikidata': 'https://www.wikidata.org/wiki/Q521', 'display_name': 'Physiology', 'level': 1, 'score': 0.36054158}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.35485}, {'id': 'https://openalex.org/C16685009', 'wikidata': 'https://www.wikidata.org/wiki/Q335057', 'display_name': 'Andrology', 'level': 1, 'score': 0.32858458}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.2878331}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.077934265}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D004912', 'descriptor_name': 'Erythrocytes', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D015767', 'descriptor_name': 'Mefloquine', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D010949', 'descriptor_name': 'Plasma', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': True}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004912', 'descriptor_name': 'Erythrocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015767', 'descriptor_name': 'Mefloquine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010949', 'descriptor_name': 'Plasma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010963', 'descriptor_name': 'Plasmodium falciparum', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012737', 'descriptor_name': 'Sex Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.4269/ajtmh.13-0328', 'pdf_url': 'http://www.ajtmh.org/deliver/fulltext/14761645/89/4/737.pdf?itemId=%2Fcontent%2Fjournals%2F10.4269%2Fajtmh.13-0328&mimeType=pdf&containerItemId=content/journals/14761645', 'source': {'id': 'https://openalex.org/S100045985', 'display_name': 'American Journal of Tropical Medicine and Hygiene', 'issn_l': '0002-9637', 'issn': ['0002-9637', '1476-1645'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315658', 'host_organization_name': 'American Society of Tropical Medicine and Hygiene', 'host_organization_lineage': ['https://openalex.org/P4310315658'], 'host_organization_lineage_names': ['American Society of Tropical Medicine and Hygiene'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/10069/33998', 'pdf_url': 'https://nagasaki-u.repo.nii.ac.jp/record/6973/files/AJTMH89_737.pdf', 'source': {'id': 'https://openalex.org/S4306400113', 'display_name': "Nagasaki University's Academic Output SITE (Nagasaki University)", 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I43777268', 'host_organization_name': 'Nagasaki University', 'host_organization_lineage': ['https://openalex.org/I43777268'], 'host_organization_lineage_names': ['Nagasaki University'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3795105', 'pdf_url': 'https://europepmc.org/articles/pmc3795105?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795105', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24002481', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.4269/ajtmh.13-0328', 'pdf_url': 'http://www.ajtmh.org/deliver/fulltext/14761645/89/4/737.pdf?itemId=%2Fcontent%2Fjournals%2F10.4269%2Fajtmh.13-0328&mimeType=pdf&containerItemId=content/journals/14761645', 'source': {'id': 'https://openalex.org/S100045985', 'display_name': 'American Journal of Tropical Medicine and Hygiene', 'issn_l': '0002-9637', 'issn': ['0002-9637', '1476-1645'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315658', 'host_organization_name': 'American Society of Tropical Medicine and Hygiene', 'host_organization_lineage': ['https://openalex.org/P4310315658'], 'host_organization_lineage_names': ['American Society of Tropical Medicine and Hygiene'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.79}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 32, 'referenced_works': ['https://openalex.org/W154338057', 'https://openalex.org/W173330408', 'https://openalex.org/W1766980394', 'https://openalex.org/W1823594715', 'https://openalex.org/W1934488471', 'https://openalex.org/W1965960128', 'https://openalex.org/W1969503178', 'https://openalex.org/W1970173074', 'https://openalex.org/W1978765607', 'https://openalex.org/W1988024530', 'https://openalex.org/W1992370441', 'https://openalex.org/W1993190682', 'https://openalex.org/W1999228678', 'https://openalex.org/W2010651882', 'https://openalex.org/W2020251171', 'https://openalex.org/W2027313042', 'https://openalex.org/W2029502167', 'https://openalex.org/W2062820605', 'https://openalex.org/W2064655152', 'https://openalex.org/W2075055204', 'https://openalex.org/W2077933771', 'https://openalex.org/W2080606952', 'https://openalex.org/W2081768970', 'https://openalex.org/W2098612202', 'https://openalex.org/W2114223824', 'https://openalex.org/W2136730510', 'https://openalex.org/W2137641881', 'https://openalex.org/W2158698574', 'https://openalex.org/W2329656484', 'https://openalex.org/W2339497051', 'https://openalex.org/W2788073857', 'https://openalex.org/W3021834003'], 'related_works': ['https://openalex.org/W7239210', 'https://openalex.org/W2472861103', 'https://openalex.org/W2419858624', 'https://openalex.org/W2409312553', 'https://openalex.org/W2402403221', 'https://openalex.org/W2398893669', 'https://openalex.org/W2295855342', 'https://openalex.org/W2209778082', 'https://openalex.org/W2144038468', 'https://openalex.org/W1986444812'], 'abstract_inverted_index': {'The': [0], 'investigation': [1], 'of': [2, 5, 50, 76, 86, 91, 117], 'gender-specific': [3], 'partitioning': [4, 90], 'the': [6, 80, 114, 131], 'antimalarial': [7], 'drug': [8], 'mefloquine': [9, 39, 77, 92, 118, 128], 'to': [10], 'cellular': [11, 133], 'and': [12, 24, 36, 42, 53, 82], 'fluid': [13], 'blood': [14, 19, 95], 'compartments': [15], 'was': [16, 70, 96], 'performed': [17], 'using': [18], 'collected': [20], 'from': [21], 'a': [22, 73], 'female': [23, 52, 108, 120], 'male': [25, 54, 111], 'healthy': [26], 'subject': [27], 'that': [28], 'were': [29, 56, 105], 'infected': [30], 'with': [31, 38, 110, 122], 'Plasmodium': [32], 'falciparum': [33], 'PCM2': [34], 'clone': [35], 'spiked': [37], '(0.25,': [40], '1,': [41], '5': [43], 'μM).': [44], 'Mefloquine': [45], 'concentrations': [46, 78, 104, 129], 'in': [47, 79, 93, 99, 107, 119, 130, 137], 'red': [48, 67, 84], 'cells': [49, 85], 'both': [51, 138], 'subjects': [55], 'significantly': [57, 102], 'higher': [58, 103], 'than': [59], 'plasma,': [60], 'which': [61], 'suggests': [62], 'an': [63], 'intensive': [64], 'uptake': [65], 'by': [66, 72], 'cells.': [68], 'This': [69], 'supported': [71], 'high': [74], 'ratio': [75], 'parasitized': [81, 94], 'non-parasitized': [83], 'about': [87], '4-fold.': [88], 'Gender-specific': [89], 'seen': [97], 'only': [98], 'plasma': [100], 'where': [101], 'observed': [106], 'compared': [109], 'plasma.': [112], 'Down-adjusting': [113], 'therapeutic': [115], 'dose': [116], 'patients': [121], 'malaria': [123], 'is': [124], 'not': [125], 'advisable': [126], 'because': [127], 'target': [132], 'compartment': [134], 'are': [135], 'similar': [136], 'genders.': [139]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2140647342', 'counts_by_year': [{'year': 2016, 'cited_by_count': 1}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-14T21:42:41.921651', 'created_date': '2016-06-24'}