Publication Information

{'id': 'https://openalex.org/W2140473883', 'doi': 'https://doi.org/10.18632/oncotarget.1202', 'title': 'Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness', 'display_name': 'Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness', 'publication_year': 2013, 'publication_date': '2013-08-06', 'ids': {'openalex': 'https://openalex.org/W2140473883', 'doi': 'https://doi.org/10.18632/oncotarget.1202', 'mag': '2140473883', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/24009080', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3824539'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.1202', 'pdf_url': 'https://www.oncotarget.com/article/1202/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://www.oncotarget.com/article/1202/pdf/', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5079070253', 'display_name': 'Helge Siemens', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Helge Siemens', 'raw_affiliation_strings': ['rimental and Molecular Pathology\nInstitute of Pathology\nLudwig-Maximilians-University Munich\nThalkirchner Strasse 36\nD-80337 Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'rimental and Molecular Pathology\nInstitute of Pathology\nLudwig-Maximilians-University Munich\nThalkirchner Strasse 36\nD-80337 Munich, Germany', 'institution_ids': ['https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5043531121', 'display_name': 'René Jackstadt', 'orcid': 'https://orcid.org/0009-0005-6246-2133'}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Rene Jackstadt', 'raw_affiliation_strings': ['rimental and Molecular Pathology\nInstitute of Pathology\nLudwig-Maximilians-University Munich\nThalkirchner Strasse 36\nD-80337 Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'rimental and Molecular Pathology\nInstitute of Pathology\nLudwig-Maximilians-University Munich\nThalkirchner Strasse 36\nD-80337 Munich, Germany', 'institution_ids': ['https://openalex.org/I8204097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090451620', 'display_name': 'Markus Kaller', 'orcid': 'https://orcid.org/0000-0003-4514-5767'}, 'institutions': [{'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Markus Kaller', 'raw_affiliation_strings': ['Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-University München, D-80337 Munich, Germany'], 'affiliations': [{'raw_affiliation_string': 'Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-University München, D-80337 Munich, Germany', 'institution_ids': ['https://openalex.org/I8204097']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5018105714', 'display_name': 'Heiko Hermeking', 'orcid': 'https://orcid.org/0000-0001-6586-4406'}, 'institutions': [{'id': 'https://openalex.org/I17937529', 'display_name': 'German Cancer Research Center', 'ror': 'https://ror.org/04cdgtt98', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I17937529']}, {'id': 'https://openalex.org/I4391767962', 'display_name': 'Deutschen Konsortium für Translationale Krebsforschung', 'ror': 'https://ror.org/02pqn3g31', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I4391767962']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}, {'id': 'https://openalex.org/I8204097', 'display_name': 'Ludwig-Maximilians-Universität München', 'ror': 'https://ror.org/05591te55', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I8204097']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Heiko Hermeking', 'raw_affiliation_strings': ['Experimental and Molecular Pathology\nInstitute of Pathology\nLudwig-Maximilians-University Munich\nThalkirchner Strasse 36\nD-80337 Munich, Germany', 'German Cancer Consortium (DKTK), D-69120 Heidelberg, Germany', 'German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany'], 'affiliations': [{'raw_affiliation_string': 'German Cancer Consortium (DKTK), D-69120 Heidelberg, Germany', 'institution_ids': ['https://openalex.org/I17937529', 'https://openalex.org/I4391767962']}, {'raw_affiliation_string': 'German Cancer Research Center (DKFZ), D-69120 Heidelberg, Germany', 'institution_ids': ['https://openalex.org/I17937529', 'https://openalex.org/I223822909']}, {'raw_affiliation_string': 'Experimental and Molecular Pathology\nInstitute of Pathology\nLudwig-Maximilians-University Munich\nThalkirchner Strasse 36\nD-80337 Munich, Germany', 'institution_ids': ['https://openalex.org/I8204097']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5018105714'], 'corresponding_institution_ids': ['https://openalex.org/I17937529', 'https://openalex.org/I4391767962', 'https://openalex.org/I223822909', 'https://openalex.org/I8204097'], 'apc_list': None, 'apc_paid': None, 'fwci': 7.995, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 134, 'citation_normalized_percentile': {'value': 0.999985, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '4', 'issue': '9', 'first_page': '1399', 'last_page': '1415'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12009', 'display_name': 'Hedgehog Signaling Pathway Studies', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12009', 'display_name': 'Hedgehog Signaling Pathway Studies', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10062', 'display_name': 'MicroRNA in disease regulation', 'score': 0.9959, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10336', 'display_name': 'Cancer Cells and Metastasis', 'score': 0.993, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/ectopic-expression', 'display_name': 'Ectopic expression', 'score': 0.72355294}], 'concepts': [{'id': 'https://openalex.org/C97037327', 'wikidata': 'https://www.wikidata.org/wiki/Q5334291', 'display_name': 'Ectopic expression', 'level': 3, 'score': 0.72355294}, {'id': 'https://openalex.org/C145059251', 'wikidata': 'https://www.wikidata.org/wiki/Q310899', 'display_name': 'microRNA', 'level': 3, 'score': 0.628832}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5964446}, {'id': 'https://openalex.org/C186310378', 'wikidata': 'https://www.wikidata.org/wiki/Q941796', 'display_name': 'Psychological repression', 'level': 4, 'score': 0.51890785}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4311802}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.41270375}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.32624167}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.32311392}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.22915393}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.15233517}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.123324275}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.084867805}], 'mesh': [{'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019009', 'descriptor_name': 'Proto-Oncogene Proteins c-kit', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': True}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D020413', 'descriptor_name': "3' Untranslated Regions", 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000903', 'descriptor_name': 'Antibiotics, Antineoplastic', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000903', 'descriptor_name': 'Antibiotics, Antineoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015179', 'descriptor_name': 'Colorectal Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015536', 'descriptor_name': 'Down-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D035683', 'descriptor_name': 'MicroRNAs', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009361', 'descriptor_name': 'Neoplasm Invasiveness', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D019009', 'descriptor_name': 'Proto-Oncogene Proteins c-kit', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019009', 'descriptor_name': 'Proto-Oncogene Proteins c-kit', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D019009', 'descriptor_name': 'Proto-Oncogene Proteins c-kit', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.1202', 'pdf_url': 'https://www.oncotarget.com/article/1202/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3824539', 'pdf_url': 'https://europepmc.org/articles/pmc3824539?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3824539', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/24009080', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.18632/oncotarget.1202', 'pdf_url': 'https://www.oncotarget.com/article/1202/pdf/', 'source': {'id': 'https://openalex.org/S126644158', 'display_name': 'Oncotarget', 'issn_l': '1949-2553', 'issn': ['1949-2553'], 'is_oa': True, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310316297', 'host_organization_name': 'Impact Journals LLC', 'host_organization_lineage': ['https://openalex.org/P4310316297'], 'host_organization_lineage_names': ['Impact Journals LLC'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 93, 'referenced_works': ['https://openalex.org/W1485850033', 'https://openalex.org/W1601094160', 'https://openalex.org/W1647075334', 'https://openalex.org/W1650797637', 'https://openalex.org/W1752312133', 'https://openalex.org/W1833764316', 'https://openalex.org/W1838206574', 'https://openalex.org/W1842385793', 'https://openalex.org/W1854105605', 'https://openalex.org/W1896134422', 'https://openalex.org/W1940716206', 'https://openalex.org/W1966765679', 'https://openalex.org/W1968102833', 'https://openalex.org/W1969238905', 'https://openalex.org/W1970431885', 'https://openalex.org/W1971114732', 'https://openalex.org/W1977914780', 'https://openalex.org/W1984328540', 'https://openalex.org/W1985186732', 'https://openalex.org/W198571108', 'https://openalex.org/W1989305266', 'https://openalex.org/W1990524611', 'https://openalex.org/W1992638032', 'https://openalex.org/W1993075625', 'https://openalex.org/W1995930366', 'https://openalex.org/W2000481222', 'https://openalex.org/W2002045237', 'https://openalex.org/W2004962320', 'https://openalex.org/W2009578813', 'https://openalex.org/W2010693936', 'https://openalex.org/W2011318328', 'https://openalex.org/W2018171716', 'https://openalex.org/W2018884388', 'https://openalex.org/W2020458598', 'https://openalex.org/W2023331662', 'https://openalex.org/W2024523289', 'https://openalex.org/W2038540701', 'https://openalex.org/W2038710758', 'https://openalex.org/W2039932331', 'https://openalex.org/W2044636213', 'https://openalex.org/W2047064959', 'https://openalex.org/W2049964698', 'https://openalex.org/W2050459519', 'https://openalex.org/W2050509360', 'https://openalex.org/W2056326458', 'https://openalex.org/W2062241862', 'https://openalex.org/W2062513246', 'https://openalex.org/W2065453920', 'https://openalex.org/W2066633590', 'https://openalex.org/W2069266255', 'https://openalex.org/W2070032322', 'https://openalex.org/W2070602415', 'https://openalex.org/W2070765029', 'https://openalex.org/W2071136034', 'https://openalex.org/W2074766088', 'https://openalex.org/W2078258148', 'https://openalex.org/W2080473622', 'https://openalex.org/W2082399298', 'https://openalex.org/W2083381199', 'https://openalex.org/W2083700925', 'https://openalex.org/W2085419928', 'https://openalex.org/W2087206434', 'https://openalex.org/W2090374150', 'https://openalex.org/W2105493915', 'https://openalex.org/W2111129864', 'https://openalex.org/W2111655556', 'https://openalex.org/W2112060964', 'https://openalex.org/W2112173990', 'https://openalex.org/W2116886958', 'https://openalex.org/W2119905127', 'https://openalex.org/W2123769728', 'https://openalex.org/W2127027577', 'https://openalex.org/W2127851311', 'https://openalex.org/W2131596261', 'https://openalex.org/W2138343959', 'https://openalex.org/W2138799354', 'https://openalex.org/W2139028067', 'https://openalex.org/W2140167385', 'https://openalex.org/W2140477106', 'https://openalex.org/W2144566858', 'https://openalex.org/W2147807172', 'https://openalex.org/W2149604229', 'https://openalex.org/W2150162161', 'https://openalex.org/W2154294588', 'https://openalex.org/W2158568863', 'https://openalex.org/W2167434633', 'https://openalex.org/W2168164296', 'https://openalex.org/W2170685293', 'https://openalex.org/W2262414037', 'https://openalex.org/W2284118197', 'https://openalex.org/W2404763614', 'https://openalex.org/W57780008', 'https://openalex.org/W69990049'], 'related_works': ['https://openalex.org/W4294671479', 'https://openalex.org/W3112004363', 'https://openalex.org/W2793009974', 'https://openalex.org/W2613842309', 'https://openalex.org/W2296384492', 'https://openalex.org/W2118929335', 'https://openalex.org/W2117627298', 'https://openalex.org/W2059361584', 'https://openalex.org/W2032519445', 'https://openalex.org/W1543402492'], 'abstract_inverted_index': {'//': [0, 50], 'Helge': [1], 'Siemens': [2], '1': [3, 7, 11, 16], ',': [4, 8, 231, 233, 235, 263], 'Rene': [5], 'Jackstadt': [6], 'Markus': [9], 'Kaller': [10], 'and': [12, 18, 141, 237, 257, 265, 268, 294, 317], 'Heiko': [13, 47], 'Hermeking': [14], '1,2,3': [15], 'Experimental': [17], 'Molecular': [19], 'Pathology,': [20, 23], 'Institute': [21], 'of': [22, 87, 98, 118, 149, 155, 159, 198, 226, 244, 255, 292], 'Ludwig-Maximilians-University': [24], 'München,': [25], 'D-80337': [26], 'Munich,': [27], 'Germany': [28, 36, 45], '2': [29], 'German': [30, 38], 'Cancer': [31, 39], 'Consortium': [32], '(DKTK),': [33], 'D-69120': [34, 43], 'Heidelberg,': [35, 44], '3': [37], 'Research': [40], 'Center': [41], '(DKFZ),': [42], 'Correspondence:': [46], 'Hermeking,': [48], 'email:': [49], 'Keywords': [51], ':': [52, 61, 66, 71], 'p53,': [53], 'miR-34a,': [54], 'miR-34b/c,': [55], 'c-Kit,': [56], 'migration,': [57], 'chemoresistance,': [58], 'stemness': [59, 206, 259], 'Received': [60], 'July': [62], '23,': [63], '2013': [64, 69, 74], 'Accepted': [65], 'August': [67, 72], '4,': [68], 'Published': [70], '6,': [73], 'Abstract': [75], 'The': [76], 'c-Kit': [77, 119, 150, 156, 180, 217, 256, 286], 'receptor': [78], 'tyrosine': [79], 'kinase': [80], 'is': [81, 91], 'commonly': [82], 'over-expressed': [83], 'in': [84, 95, 127, 135, 138, 208, 249], 'different': [85], 'types': [86], 'cancer.': [88], 'p53': [89, 121], 'activation': [90, 243], 'known': [92], 'to': [93, 164, 175, 279], 'result': [94], 'the': [96, 101, 111, 128, 147, 173, 241, 253], 'down-regulation': [97, 148], 'c-Kit.': [99], 'However,': [100], 'underlying': [102], 'mechanism': [103], 'has': [104], 'remained': [105], 'unknown.': [106], 'Here,': [107], 'we': [108], 'show': [109], 'that': [110, 296], 'p53-induced': [112], 'miR-34': [113, 293], 'microRNA': [114], 'family': [115], 'mediates': [116], 'repression': [117], 'by': [120], 'via': [122], 'a': [123, 136, 199, 221, 245, 288], 'conserved': [124], 'seed-matching': [125], 'sequence': [126], 'c-': [129, 201], 'Kit': [130, 202], "3'-UTR.": [131], 'Ectopic': [132], 'miR-34a': [133, 171, 193, 247], 'resulted': [134], 'decrease': [137], 'Erk': [139], 'signaling': [140], 'transformation,': [142], 'which': [143], 'was': [144], 'dependent': [145], 'on': [146, 304], 'expression.': [151], 'Furthermore,': [152], 'ectopic': [153, 170, 192], 'expression': [154, 218, 254], 'conferred': [157], 'resistance': [158], 'colorectal': [160], 'cancer': [161, 305], '(CRC)': [162], 'cells': [163, 174, 187, 251], 'treatment': [165], 'with': [166, 179, 224, 300], '5-fluorouracil': [167], '(5-FU),': [168], 'whereas': [169, 191], 'sensitized': [172], '5-FU.': [176], 'After': [177], 'stimulation': [178], 'ligand/stem': [181], 'cell': [182], 'factor': [183], '(SCF)': [184], 'Colo320': [185], 'CRC': [186, 210, 214], 'displayed': [188], 'increased': [189], 'migration/invasion,': [190], 'inhibited': [194], 'SCF-induced': [195], 'migration/invasion.': [196], 'Activation': [197], 'conditional': [200, 246], 'allele': [203, 248], 'induced': [204], 'several': [205, 258, 301], 'markers': [207, 225, 260], 'DLD-1': [209, 250], 'cells.': [211, 306], 'In': [212], 'primary': [213], 'samples': [215], 'elevated': [216], 'also': [219, 273], 'showed': [220], 'positive': [222], 'correlation': [223], 'stemness,': [227], 'such': [228], 'as': [229, 287], 'Lgr5': [230, 264], 'CD44': [232, 262], 'OLFM4': [234], 'BMI-1': [236, 266], 'β-catenin': [238], '.': [239], 'On': [240], 'contrary,': [242], 'diminished': [252], '(': [261], ')': [267], 'suppressed': [269, 274], 'sphere': [270], 'formation.': [271], 'MiR-34a': [272], 'enhanced': [275], 'sphere-formation': [276], 'after': [277], 'exposure': [278], 'SCF.': [280], 'Taken': [281], 'together,': [282], 'our': [283], 'data': [284], 'establish': [285], 'new': [289], 'direct': [290], 'target': [291], 'demonstrate': [295], 'this': [297, 308], 'regulation': [298, 309], 'interferes': [299], 'c-Kit-mediated': [302], 'effects': [303], 'Therefore,': [307], 'may': [310], 'be': [311], 'potentially': [312], 'relevant': [313], 'for': [314], 'future': [315], 'diagnostic': [316], 'therapeutic': [318], 'approaches.': [319]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2140473883', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 14}, {'year': 2017, 'cited_by_count': 17}, {'year': 2016, 'cited_by_count': 15}, {'year': 2015, 'cited_by_count': 21}, {'year': 2014, 'cited_by_count': 25}, {'year': 2013, 'cited_by_count': 2}], 'updated_date': '2024-12-15T05:39:19.369179', 'created_date': '2016-06-24'}