Title: The levels of TNFα, IL4 and IL10 production by T-cells in B-cell chronic lymphocytic leukaemia (B-CLL)
Abstract: Tumour necrosis factor alpha (TNFα), interleukin (IL) 4 and IL10 are important for the growth and survival of the leukaemic cells in B-cell chronic lymphocytic leukaemia (B-CLL). The present study investigates the production of TNFα, IL4 and IL10 in patients with B-CLL. Significant increases in the TNFα and IL4 mean levels compared to normal control CD2+-cells were observed for B-CLL lymphocytes (TNFα: P=0.0004 and IL4: P=0.0026). By contrast, the mean level of IL10 produced by purified B-CLL CD2+-cells was significantly lower than that seen with normal control T-cells (P=0.0136). No significant difference in the percentage (%) of T-cells that expressed cytoplasmic TNFα, IL4 and IL10 was observed between B-CLL and normal T-cells. However, a significant increase in the mean level of intracellular TNFα and IL4 expression was observed in B-CLL compared with normal control T-cells (TNFα: P=0.031; IL4: P=0.0027). The increased expression of cytoplasmic TNFα and IL4 appeared to be associated with increased cytokine production in the tested samples. The differences observed with some B-CLL cases in the production of TNFα, IL4 and IL10 by peripheral blood T-cells may suggest survival mechanisms for the leukaemic cells in these patients.
Publication Year: 2001
Publication Date: 2001-02-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 35
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot