Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2140248834', 'doi': 'https://doi.org/10.2337/db12-1414', 'title': 'Congenital Hyperinsulinism Caused by Hexokinase I Expression or Glucokinase-Activating Mutation in a Subset of β-Cells', 'display_name': 'Congenital Hyperinsulinism Caused by Hexokinase I Expression or Glucokinase-Activating Mutation in a Subset of β-Cells', 'publication_year': 2013, 'publication_date': '2013-04-16', 'ids': {'openalex': 'https://openalex.org/W2140248834', 'doi': 'https://doi.org/10.2337/db12-1414', 'mag': '2140248834', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/23274908', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3636634'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2337/db12-1414', 'pdf_url': 'https://diabetes.diabetesjournals.org/content/diabetes/62/5/1689.full.pdf', 'source': {'id': 'https://openalex.org/S129060628', 'display_name': 'Diabetes', 'issn_l': '0012-1797', 'issn': ['0012-1797', '1939-327X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320274', 'host_organization_name': 'American Diabetes Association', 'host_organization_lineage': ['https://openalex.org/P4310320274'], 'host_organization_lineage_names': ['American Diabetes Association'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://diabetes.diabetesjournals.org/content/diabetes/62/5/1689.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5076977607', 'display_name': 'Jean‐Claude Henquin', 'orcid': 'https://orcid.org/0000-0002-4267-4797'}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Jean-Claude Henquin', 'raw_affiliation_strings': ['1Unit of Endocrinology and Metabolism, University of Louvain, Faculty of Medicine, Brussels, Belgium'], 'affiliations': [{'raw_affiliation_string': '1Unit of Endocrinology and Metabolism, University of Louvain, Faculty of Medicine, Brussels, Belgium', 'institution_ids': ['https://openalex.org/I99464096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052684432', 'display_name': 'Christine Sempoux', 'orcid': 'https://orcid.org/0000-0003-1375-3979'}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Christine Sempoux', 'raw_affiliation_strings': ['2Department of Pathology, University of Louvain, Faculty of Medicine, Brussels, Belgium'], 'affiliations': [{'raw_affiliation_string': '2Department of Pathology, University of Louvain, Faculty of Medicine, Brussels, Belgium', 'institution_ids': ['https://openalex.org/I99464096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004171101', 'display_name': 'Joëlle Marchandise', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Joelle Marchandise', 'raw_affiliation_strings': ['2Department of Pathology, University of Louvain, Faculty of Medicine, Brussels, Belgium'], 'affiliations': [{'raw_affiliation_string': '2Department of Pathology, University of Louvain, Faculty of Medicine, Brussels, Belgium', 'institution_ids': ['https://openalex.org/I99464096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089538506', 'display_name': 'Sebastien Godecharles', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Sebastien Godecharles', 'raw_affiliation_strings': ['2Department of Pathology, University of Louvain, Faculty of Medicine, Brussels, Belgium'], 'affiliations': [{'raw_affiliation_string': '2Department of Pathology, University of Louvain, Faculty of Medicine, Brussels, Belgium', 'institution_ids': ['https://openalex.org/I99464096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029138905', 'display_name': 'Yves Guiot', 'orcid': 'https://orcid.org/0000-0003-4120-0204'}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Yves Guiot', 'raw_affiliation_strings': ['2Department of Pathology, University of Louvain, Faculty of Medicine, Brussels, Belgium'], 'affiliations': [{'raw_affiliation_string': '2Department of Pathology, University of Louvain, Faculty of Medicine, Brussels, Belgium', 'institution_ids': ['https://openalex.org/I99464096']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050215643', 'display_name': 'Myriam Nenquin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Myriam Nenquin', 'raw_affiliation_strings': ['1Unit of Endocrinology and Metabolism, University of Louvain, Faculty of Medicine, Brussels, Belgium'], 'affiliations': [{'raw_affiliation_string': '1Unit of Endocrinology and Metabolism, University of Louvain, Faculty of Medicine, Brussels, Belgium', 'institution_ids': ['https://openalex.org/I99464096']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5047052242', 'display_name': 'Jacques Rahier', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I99464096', 'display_name': 'KU Leuven', 'ror': 'https://ror.org/05f950310', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I99464096']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Jacques Rahier', 'raw_affiliation_strings': ['2Department of Pathology, University of Louvain, Faculty of Medicine, Brussels, Belgium'], 'affiliations': [{'raw_affiliation_string': '2Department of Pathology, University of Louvain, Faculty of Medicine, Brussels, Belgium', 'institution_ids': ['https://openalex.org/I99464096']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 5.14, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 63, 'citation_normalized_percentile': {'value': 0.999921, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '62', 'issue': '5', 'first_page': '1689', 'last_page': '1696'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11623', 'display_name': 'Impact of Hyperglycemia on Health Outcomes', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11623', 'display_name': 'Impact of Hyperglycemia on Health Outcomes', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic Islet Dysfunction and Regeneration', 'score': 0.999, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10560', 'display_name': 'Management of Diabetes Mellitus and Hypoglycemia', 'score': 0.9801, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/diazoxide', 'display_name': 'Diazoxide', 'score': 0.9515432}, {'id': 'https://openalex.org/keywords/glucokinase', 'display_name': 'Glucokinase', 'score': 0.91252875}, {'id': 'https://openalex.org/keywords/congenital-hyperinsulinism', 'display_name': 'Congenital hyperinsulinism', 'score': 0.87384176}, {'id': 'https://openalex.org/keywords/tolbutamide', 'display_name': 'Tolbutamide', 'score': 0.8011558}, {'id': 'https://openalex.org/keywords/hexokinase', 'display_name': 'Hexokinase', 'score': 0.59150225}, {'id': 'https://openalex.org/keywords/hypoglycemia', 'display_name': 'Hypoglycemia', 'score': 0.550176}, {'id': 'https://openalex.org/keywords/hyperglycemia', 'display_name': 'Hyperglycemia', 'score': 0.53734}, {'id': 'https://openalex.org/keywords/pancreas-development', 'display_name': 'Pancreas Development', 'score': 0.521736}, {'id': 'https://openalex.org/keywords/insulin-secretion', 'display_name': 'Insulin Secretion', 'score': 0.519192}, {'id': 'https://openalex.org/keywords/continuous-glucose-monitoring', 'display_name': 'Continuous Glucose Monitoring', 'score': 0.517981}, {'id': 'https://openalex.org/keywords/hyperinsulinemic-hypoglycemia', 'display_name': 'Hyperinsulinemic hypoglycemia', 'score': 0.41990113}], 'concepts': [{'id': 'https://openalex.org/C2779872217', 'wikidata': 'https://www.wikidata.org/wiki/Q420009', 'display_name': 'Diazoxide', 'level': 3, 'score': 0.9515432}, {'id': 'https://openalex.org/C98335778', 'wikidata': 'https://www.wikidata.org/wiki/Q425185', 'display_name': 'Glucokinase', 'level': 3, 'score': 0.91252875}, {'id': 'https://openalex.org/C2777643638', 'wikidata': 'https://www.wikidata.org/wiki/Q5160437', 'display_name': 'Congenital hyperinsulinism', 'level': 5, 'score': 0.87384176}, {'id': 'https://openalex.org/C2776054734', 'wikidata': 'https://www.wikidata.org/wiki/Q414275', 'display_name': 'Tolbutamide', 'level': 3, 'score': 0.8011558}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.76514876}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.7484845}, {'id': 'https://openalex.org/C2777368190', 'wikidata': 'https://www.wikidata.org/wiki/Q477390', 'display_name': 'Hyperinsulinism', 'level': 4, 'score': 0.6321309}, {'id': 'https://openalex.org/C2780668416', 'wikidata': 'https://www.wikidata.org/wiki/Q202758', 'display_name': 'Hypoglycemia', 'level': 3, 'score': 0.5999945}, {'id': 'https://openalex.org/C2779826832', 'wikidata': 'https://www.wikidata.org/wiki/Q982914', 'display_name': 'Hexokinase', 'level': 4, 'score': 0.59150225}, {'id': 'https://openalex.org/C2778764654', 'wikidata': 'https://www.wikidata.org/wiki/Q9618', 'display_name': 'Pancreas', 'level': 2, 'score': 0.5248696}, {'id': 'https://openalex.org/C165220095', 'wikidata': 'https://www.wikidata.org/wiki/Q207524', 'display_name': 'Islet', 'level': 3, 'score': 0.4601849}, {'id': 'https://openalex.org/C2779306644', 'wikidata': 'https://www.wikidata.org/wiki/Q2002370', 'display_name': 'Insulin', 'level': 2, 'score': 0.45123348}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.43671894}, {'id': 'https://openalex.org/C2781156865', 'wikidata': 'https://www.wikidata.org/wiki/Q827023', 'display_name': 'Lesion', 'level': 2, 'score': 0.42090058}, {'id': 'https://openalex.org/C2775858560', 'wikidata': 'https://www.wikidata.org/wiki/Q11612732', 'display_name': 'Hyperinsulinemic hypoglycemia', 'level': 4, 'score': 0.41990113}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.33176026}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.15254351}, {'id': 'https://openalex.org/C62231903', 'wikidata': 'https://www.wikidata.org/wiki/Q1057', 'display_name': 'Metabolism', 'level': 2, 'score': 0.11064407}, {'id': 'https://openalex.org/C20251656', 'wikidata': 'https://www.wikidata.org/wiki/Q162643', 'display_name': 'Glycolysis', 'level': 3, 'score': 0.10723424}, {'id': 'https://openalex.org/C2777391703', 'wikidata': 'https://www.wikidata.org/wiki/Q1053470', 'display_name': 'Insulin resistance', 'level': 3, 'score': 0.08437601}], 'mesh': [{'descriptor_ui': 'D005941', 'descriptor_name': 'Glucokinase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D006593', 'descriptor_name': 'Hexokinase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006946', 'descriptor_name': 'Hyperinsulinism', 'qualifier_ui': 'Q000151', 'qualifier_name': 'congenital', 'is_major_topic': True}, {'descriptor_ui': 'D050417', 'descriptor_name': 'Insulin-Secreting Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D019943', 'descriptor_name': 'Amino Acid Substitution', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003981', 'descriptor_name': 'Diazoxide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005941', 'descriptor_name': 'Glucokinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005941', 'descriptor_name': 'Glucokinase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006593', 'descriptor_name': 'Hexokinase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006593', 'descriptor_name': 'Hexokinase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006946', 'descriptor_name': 'Hyperinsulinism', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006946', 'descriptor_name': 'Hyperinsulinism', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006946', 'descriptor_name': 'Hyperinsulinism', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D006946', 'descriptor_name': 'Hyperinsulinism', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D007004', 'descriptor_name': 'Hypoglycemic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007231', 'descriptor_name': 'Infant, Newborn', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007328', 'descriptor_name': 'Insulin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000078790', 'descriptor_name': 'Insulin Secretion', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050417', 'descriptor_name': 'Insulin-Secreting Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050417', 'descriptor_name': 'Insulin-Secreting Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D050417', 'descriptor_name': 'Insulin-Secreting Cells', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D014044', 'descriptor_name': 'Tolbutamide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.2337/db12-1414', 'pdf_url': 'https://diabetes.diabetesjournals.org/content/diabetes/62/5/1689.full.pdf', 'source': {'id': 'https://openalex.org/S129060628', 'display_name': 'Diabetes', 'issn_l': '0012-1797', 'issn': ['0012-1797', '1939-327X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320274', 'host_organization_name': 'American Diabetes Association', 'host_organization_lineage': ['https://openalex.org/P4310320274'], 'host_organization_lineage_names': ['American Diabetes Association'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3636634', 'pdf_url': 'https://europepmc.org/articles/pmc3636634?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636634', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/23274908', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.2337/db12-1414', 'pdf_url': 'https://diabetes.diabetesjournals.org/content/diabetes/62/5/1689.full.pdf', 'source': {'id': 'https://openalex.org/S129060628', 'display_name': 'Diabetes', 'issn_l': '0012-1797', 'issn': ['0012-1797', '1939-327X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320274', 'host_organization_name': 'American Diabetes Association', 'host_organization_lineage': ['https://openalex.org/P4310320274'], 'host_organization_lineage_names': ['American Diabetes Association'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.4}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 53, 'referenced_works': ['https://openalex.org/W1545562191', 'https://openalex.org/W1602411554', 'https://openalex.org/W182829428', 'https://openalex.org/W1966414759', 'https://openalex.org/W1972987087', 'https://openalex.org/W1975863794', 'https://openalex.org/W1977796924', 'https://openalex.org/W1980659600', 'https://openalex.org/W1986381180', 'https://openalex.org/W1986421416', 'https://openalex.org/W1990312465', 'https://openalex.org/W1990428892', 'https://openalex.org/W2011413530', 'https://openalex.org/W2015001567', 'https://openalex.org/W2019482161', 'https://openalex.org/W2022424814', 'https://openalex.org/W2031821584', 'https://openalex.org/W2038353863', 'https://openalex.org/W2051677297', 'https://openalex.org/W2059757087', 'https://openalex.org/W2068524200', 'https://openalex.org/W2069799200', 'https://openalex.org/W2082368169', 'https://openalex.org/W2083829302', 'https://openalex.org/W2086491850', 'https://openalex.org/W2093632126', 'https://openalex.org/W2097248117', 'https://openalex.org/W2097689482', 'https://openalex.org/W2098899089', 'https://openalex.org/W2102112706', 'https://openalex.org/W2106340369', 'https://openalex.org/W2112163906', 'https://openalex.org/W2112662561', 'https://openalex.org/W2115981867', 'https://openalex.org/W2122015665', 'https://openalex.org/W2125505360', 'https://openalex.org/W2126412386', 'https://openalex.org/W2133560510', 'https://openalex.org/W2137740936', 'https://openalex.org/W2139359616', 'https://openalex.org/W2141905411', 'https://openalex.org/W2147284000', 'https://openalex.org/W2153368969', 'https://openalex.org/W2162204892', 'https://openalex.org/W2165848705', 'https://openalex.org/W2170024682', 'https://openalex.org/W2322041353', 'https://openalex.org/W2330339020', 'https://openalex.org/W4250622522', 'https://openalex.org/W4251901664', 'https://openalex.org/W4255697252', 'https://openalex.org/W4285719527', 'https://openalex.org/W4300991635'], 'related_works': ['https://openalex.org/W574225650', 'https://openalex.org/W4220907907', 'https://openalex.org/W3207501977', 'https://openalex.org/W3201598847', 'https://openalex.org/W3029174558', 'https://openalex.org/W2802204647', 'https://openalex.org/W2050708063', 'https://openalex.org/W2018567111', 'https://openalex.org/W177569859', 'https://openalex.org/W1559840198'], 'abstract_inverted_index': {'Congenital': [0], 'hyperinsulinism': [1], 'causes': [2], 'persistent': [3], 'hypoglycemia': [4], 'in': [5, 23, 28, 84, 156, 173], 'neonates': [6], 'and': [7, 91, 114, 125], 'infants.': [8], 'Most': [9], 'often,': [10], 'uncontrolled': [11], 'insulin': [12], 'secretion': [13], '(IS)': [14], 'results': [15], 'from': [16, 95], 'a': [17, 31, 71, 135, 194, 200], 'lack': [18], 'of': [19, 89, 100, 138, 146, 153, 158, 168, 196, 203], 'functional': [20], 'KATP': [21, 40, 72], 'channels': [22], 'all': [24], 'β-cells': [25, 29, 157], 'or': [26], 'only': [27], 'within': [30, 47], 'resectable': [32], 'focal': [33, 73, 204], 'lesion.': [34], 'In': [35, 105, 144, 162], 'more': [36], 'rare': [37], 'cases,': [38, 148], 'without': [39], 'channel': [41], 'mutations,': [42], 'hyperfunctional': [43, 159], 'islets': [44, 52, 160, 175], 'are': [45, 53], 'confined': [46], 'few': [48], 'lobules,': [49], 'whereas': [50], 'hypofunctional': [51], 'present': [54], 'throughout': [55], 'the': [56, 128], 'pancreas.': [57], 'They': [58, 198], 'also': [59], 'can': [60], 'be': [61], 'cured': [62], 'by': [63, 87, 118, 140, 193], 'selective': [64], 'partial': [65], 'pancreatectomy;': [66], 'however,': [67], 'unlike': [68], 'those': [69], 'with': [70], 'lesion,': [74], 'they': [75], 'show': [76], 'clinical': [77], 'sensitivity': [78], 'to': [79, 180], 'diazoxide.': [80], 'Here,': [81], 'we': [82], 'characterized': [83], 'vitro': [85], 'IS': [86, 108, 124, 139, 188], 'fragments': [88], 'pathological': [90, 106, 174], 'adjacent': [92], 'normal': [93, 101], 'pancreas': [94, 102], 'six': [96, 147], 'such': [97], 'cases.': [98], 'Responses': [99], 'were': [103], 'unremarkable.': [104], 'region,': [107], 'was': [109, 115, 134, 171], 'elevated': [110], 'at': [111, 189], '1': [112, 141], 'mmol/L': [113, 120, 142], 'further': [116], 'increased': [117], '15': [119], 'glucose.': [121, 143], 'Diazoxide': [122], 'suppressed': [123], 'tolbutamide': [126], 'antagonized': [127], 'inhibition.': [129], 'The': [130], 'most': [131], 'conspicuous': [132], 'anomaly': [133], 'large': [136], 'stimulation': [137], 'five': [145], 'immunohistochemistry': [149], 'revealed': [150], 'undue': [151], 'presence': [152], 'low-Km': [154], 'hexokinase-I': [155], 'only.': [161, 176], 'one': [163], 'case,': [164], 'an': [165], 'activating': [166], 'mutation': [167], 'glucokinase': [169], '(I211F)': [170], 'found': [172], 'Both': [177], 'abnormalities,': [178], 'attributed': [179], 'somatic': [181], 'genetic': [182], 'events,': [183], 'may': [184], 'account': [185], 'for': [186], 'inappropriate': [187], 'low': [190], 'glucose': [191], 'levels': [192], 'subset': [195], 'β-cells.': [197], 'represent': [199], 'novel': [201], 'cause': [202], 'congenital': [205], 'hyperinsulinism.': [206]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2140248834', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 8}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 8}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 5}], 'updated_date': '2024-09-01T00:05:24.791184', 'created_date': '2016-06-24'}