Publication Information

{'id': 'https://openalex.org/W2139932649', 'doi': 'https://doi.org/10.1093/rpd/ncv178', 'title': 'Biological effects of proton radiation: an update: Figure 1.', 'display_name': 'Biological effects of proton radiation: an update: Figure 1.', 'publication_year': 2015, 'publication_date': '2015-04-20', 'ids': {'openalex': 'https://openalex.org/W2139932649', 'doi': 'https://doi.org/10.1093/rpd/ncv178', 'mag': '2139932649', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/25897135'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/rpd/ncv178', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S201595455', 'display_name': 'Radiation Protection Dosimetry', 'issn_l': '0144-8420', 'issn': ['0144-8420', '1742-3406'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5077267439', 'display_name': 'Swati Girdhani', 'orcid': 'https://orcid.org/0000-0003-4307-0917'}, 'institutions': [{'id': 'https://openalex.org/I121934306', 'display_name': 'Tufts University', 'ror': 'https://ror.org/05wvpxv85', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I121934306']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'S. Girdhani', 'raw_affiliation_strings': ['Center of Cancer Systems Biology, GRI, Tufts University School of Medicine, Boston, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Center of Cancer Systems Biology, GRI, Tufts University School of Medicine, Boston, MA, USA', 'institution_ids': ['https://openalex.org/I121934306']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009898650', 'display_name': 'Rainer K. Sachs', 'orcid': 'https://orcid.org/0000-0002-9300-374X'}, 'institutions': [{'id': 'https://openalex.org/I95457486', 'display_name': 'University of California, Berkeley', 'ror': 'https://ror.org/01an7q238', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I95457486']}, {'id': 'https://openalex.org/I121934306', 'display_name': 'Tufts University', 'ror': 'https://ror.org/05wvpxv85', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I121934306']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'R. Sachs', 'raw_affiliation_strings': ['Center of Cancer Systems Biology, GRI, Tufts University School of Medicine, Boston, MA, USA', 'Department of Mathematics, University of California, Berkeley, CA, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Mathematics, University of California, Berkeley, CA, USA', 'institution_ids': ['https://openalex.org/I95457486']}, {'raw_affiliation_string': 'Center of Cancer Systems Biology, GRI, Tufts University School of Medicine, Boston, MA, USA', 'institution_ids': ['https://openalex.org/I121934306']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5034908463', 'display_name': 'Lynn Hlatky', 'orcid': 'https://orcid.org/0000-0002-2340-8119'}, 'institutions': [{'id': 'https://openalex.org/I121934306', 'display_name': 'Tufts University', 'ror': 'https://ror.org/05wvpxv85', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I121934306']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'L. Hlatky', 'raw_affiliation_strings': ['Center of Cancer Systems Biology, GRI, Tufts University School of Medicine, Boston, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Center of Cancer Systems Biology, GRI, Tufts University School of Medicine, Boston, MA, USA', 'institution_ids': ['https://openalex.org/I121934306']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5077267439', 'https://openalex.org/A5034908463'], 'corresponding_institution_ids': ['https://openalex.org/I121934306', 'https://openalex.org/I121934306'], 'apc_list': {'value': 4151, 'currency': 'USD', 'value_usd': 4151, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 2.182, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 23, 'citation_normalized_percentile': {'value': 0.927332, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '166', 'issue': '1-4', 'first_page': '334', 'last_page': '338'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11176', 'display_name': 'Radiation Therapy and Dosimetry', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11176', 'display_name': 'Radiation Therapy and Dosimetry', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11359', 'display_name': 'Effects of Radiation Exposure', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10958', 'display_name': 'Ultrasound and Hyperthermia Applications', 'score': 0.9883, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/radiobiology', 'display_name': 'Radiobiology', 'score': 0.8180347}, {'id': 'https://openalex.org/keywords/relative-biological-effectiveness', 'display_name': 'Relative biological effectiveness', 'score': 0.7703965}, {'id': 'https://openalex.org/keywords/linear-energy-transfer', 'display_name': 'Linear energy transfer', 'score': 0.7690586}, {'id': 'https://openalex.org/keywords/biological-effect', 'display_name': 'Biological effect', 'score': 0.4884054}], 'concepts': [{'id': 'https://openalex.org/C125118446', 'wikidata': 'https://www.wikidata.org/wiki/Q690200', 'display_name': 'Radiobiology', 'level': 3, 'score': 0.8180347}, {'id': 'https://openalex.org/C11928243', 'wikidata': 'https://www.wikidata.org/wiki/Q1360981', 'display_name': 'Relative biological effectiveness', 'level': 3, 'score': 0.7703965}, {'id': 'https://openalex.org/C86611320', 'wikidata': 'https://www.wikidata.org/wiki/Q1699996', 'display_name': 'Linear energy transfer', 'level': 3, 'score': 0.7690586}, {'id': 'https://openalex.org/C54516573', 'wikidata': 'https://www.wikidata.org/wiki/Q2294', 'display_name': 'Proton', 'level': 2, 'score': 0.5998498}, {'id': 'https://openalex.org/C153385146', 'wikidata': 'https://www.wikidata.org/wiki/Q18335', 'display_name': 'Radiation', 'level': 2, 'score': 0.52387804}, {'id': 'https://openalex.org/C2779244869', 'wikidata': 'https://www.wikidata.org/wiki/Q507667', 'display_name': 'Proton therapy', 'level': 3, 'score': 0.5112927}, {'id': 'https://openalex.org/C509974204', 'wikidata': 'https://www.wikidata.org/wiki/Q180507', 'display_name': 'Radiation therapy', 'level': 2, 'score': 0.4957808}, {'id': 'https://openalex.org/C2987851454', 'wikidata': 'https://www.wikidata.org/wiki/Q3736076', 'display_name': 'Biological effect', 'level': 2, 'score': 0.4884054}, {'id': 'https://openalex.org/C19527891', 'wikidata': 'https://www.wikidata.org/wiki/Q1120908', 'display_name': 'Medical physics', 'level': 1, 'score': 0.47082737}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.38053054}, {'id': 'https://openalex.org/C2989005', 'wikidata': 'https://www.wikidata.org/wiki/Q214963', 'display_name': 'Nuclear medicine', 'level': 1, 'score': 0.37584317}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.32258728}, {'id': 'https://openalex.org/C185544564', 'wikidata': 'https://www.wikidata.org/wiki/Q81197', 'display_name': 'Nuclear physics', 'level': 1, 'score': 0.17078412}, {'id': 'https://openalex.org/C126838900', 'wikidata': 'https://www.wikidata.org/wiki/Q77604', 'display_name': 'Radiology', 'level': 1, 'score': 0.13462797}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.104509115}], 'mesh': [{'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000532', 'qualifier_name': 'radiotherapy', 'is_major_topic': True}, {'descriptor_ui': 'D009389', 'descriptor_name': 'Neovascularization, Pathologic', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D061766', 'descriptor_name': 'Proton Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D011832', 'descriptor_name': 'Radiation Injuries', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D018787', 'descriptor_name': 'Radiation Oncology', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D004307', 'descriptor_name': 'Dose-Response Relationship, Radiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005720', 'descriptor_name': 'Gamma Rays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009361', 'descriptor_name': 'Neoplasm Invasiveness', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009389', 'descriptor_name': 'Neovascularization, Pathologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011832', 'descriptor_name': 'Radiation Injuries', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018787', 'descriptor_name': 'Radiation Oncology', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012062', 'descriptor_name': 'Relative Biological Effectiveness', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1093/rpd/ncv178', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S201595455', 'display_name': 'Radiation Protection Dosimetry', 'issn_l': '0144-8420', 'issn': ['0144-8420', '1742-3406'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/25897135', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.86, 'display_name': 'Affordable and clean energy', 'id': 'https://metadata.un.org/sdg/7'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 28, 'referenced_works': ['https://openalex.org/W1482076735', 'https://openalex.org/W1496390158', 'https://openalex.org/W1918337600', 'https://openalex.org/W1965902856', 'https://openalex.org/W1973046986', 'https://openalex.org/W1973326332', 'https://openalex.org/W1978235312', 'https://openalex.org/W1994547407', 'https://openalex.org/W2034017959', 'https://openalex.org/W2049030453', 'https://openalex.org/W2063919773', 'https://openalex.org/W2086862863', 'https://openalex.org/W2100975996', 'https://openalex.org/W2101961850', 'https://openalex.org/W2105108859', 'https://openalex.org/W2122656686', 'https://openalex.org/W2131854790', 'https://openalex.org/W2133730805', 'https://openalex.org/W2140370697', 'https://openalex.org/W2142096147', 'https://openalex.org/W2145995799', 'https://openalex.org/W2159789252', 'https://openalex.org/W2162113821', 'https://openalex.org/W2166223410', 'https://openalex.org/W2166227465', 'https://openalex.org/W2232660545', 'https://openalex.org/W2324677651', 'https://openalex.org/W2410531723'], 'related_works': ['https://openalex.org/W3002379442', 'https://openalex.org/W2944246952', 'https://openalex.org/W2898672813', 'https://openalex.org/W2802766591', 'https://openalex.org/W2789106093', 'https://openalex.org/W2165130376', 'https://openalex.org/W2139932649', 'https://openalex.org/W2073754193', 'https://openalex.org/W2036129744', 'https://openalex.org/W2014520721'], 'abstract_inverted_index': {'Proton': [0], 'radiation': [1, 10, 71, 83, 126], 'provides': [2], 'significant': [3], 'dosimetric': [4], 'advantages': [5], 'when': [6], 'compared': [7], 'with': [8], 'gamma': [9], 'due': [11], 'to': [12, 37, 50, 59, 95, 101, 130, 138], 'its': [13], 'superior': [14], 'energy': [15, 46], 'deposition': [16], 'characteristics.': [17], 'Although': [18], 'the': [19, 39, 77, 98, 102], 'physical': [20], 'aspects': [21], 'of': [22, 43, 55, 76, 97, 104], 'proton': [23, 82, 125], 'radiobiology': [24], 'are': [25, 32], 'well': [26], 'understood,': [27], 'biological': [28, 41, 67, 78], 'and': [29, 88, 118], 'clinical': [30, 89], 'endpoints': [31], 'understudied.': [33], 'The': [34], 'current': [35], 'practice': [36], 'assume': [38], 'relative': [40, 58], 'effectiveness': [42], 'low': [44], 'linear': [45], 'transfer': [47], '(LET)': [48], 'protons': [49, 105], 'be': [51, 135], 'a': [52, 136, 140], 'generic': [53], 'value': [54], 'about': [56], '1.1': [57], 'photons': [60], 'likely': [61], 'obscures': [62], 'important': [63], 'unrecognised': [64], 'differentials': [65], 'in': [66, 128], 'response': [68], 'between': [69], 'these': [70, 151], 'qualities.': [72], 'A': [73], 'deeper': [74], 'understanding': [75], 'properties': [79], 'induced': [80], 'by': [81, 149], 'would': [84], 'have': [85], 'both': [86], 'radiobiological': [87], 'impact.': [90], 'This': [91], 'article': [92], 'briefly': [93], 'points': [94], 'some': [96], 'literature': [99], 'pertinent': [100], 'effects': [103], 'on': [106], 'tissue-level': [107, 152], 'processes': [108], 'that': [109, 124], 'modify': [110], 'disease': [111], 'progression,': [112], 'such': [113], 'as': [114], 'angiogenesis,': [115], 'cell': [116], 'invasion': [117], 'cancer': [119], 'metastasis.': [120], 'Recent': [121], 'findings': [122], 'hint': [123], 'may,': [127], 'addition': [129], 'offering': [131], 'improved': [132], 'radio-therapeutic': [133], 'targeting,': [134], 'means': [137], 'provide': [139], 'new': [141], 'dimension': [142], 'for': [143, 147], 'increasing': [144], 'therapeutic': [145], 'benefits': [146], 'patients': [148], 'manipulating': [150], 'processes.': [153]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2139932649', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 2}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 2}, {'year': 2016, 'cited_by_count': 3}], 'updated_date': '2024-12-08T21:03:25.367558', 'created_date': '2016-06-24'}