Title: <sup>18</sup>F‐Labeling of Peptides by means of an Organosilicon‐Based Fluoride Acceptor
Abstract: Angewandte Chemie International EditionVolume 45, Issue 36 p. 6047-6050 Communication 18F-Labeling of Peptides by means of an Organosilicon-Based Fluoride Acceptor† Ralf Schirrmacher Dr., Ralf Schirrmacher Dr. [email protected] Klinik und Poliklinik für Nuklearmedizin, Johannes Gutenberg Universität Mainz, 55131 Mainz, Germany, Fax: (+49) 6131-172386 These authors contributed equally.Search for more papers by this authorGerrit Bradtmöller Dipl.-Chem., Gerrit Bradtmöller Dipl.-Chem. Lehrstuhl für Anorganische Chemie, Universität Dortmund, 44221 Dortmund, Germany, Fax: (+49) 231-755-5048 These authors contributed equally.Search for more papers by this authorEsther Schirrmacher Dr., Esther Schirrmacher Dr. Klinik und Poliklinik für Nuklearmedizin, Johannes Gutenberg Universität Mainz, 55131 Mainz, Germany, Fax: (+49) 6131-172386 These authors contributed equally.Search for more papers by this authorOliver Thews Priv.-Doz. Dr., Oliver Thews Priv.-Doz. Dr. Institut für Physiology und Pathophysiologie, Universität Mainz, GermanySearch for more papers by this authorJulia Tillmanns, Julia Tillmanns Klinik und Poliklinik für Nuklearmedizin, Johannes Gutenberg Universität Mainz, 55131 Mainz, Germany, Fax: (+49) 6131-172386Search for more papers by this authorThomas Siessmeier Dr., Thomas Siessmeier Dr. Klinik und Poliklinik für Nuklearmedizin, Johannes Gutenberg Universität Mainz, 55131 Mainz, Germany, Fax: (+49) 6131-172386Search for more papers by this authorHans G. Buchholz Dipl.-Ing., Hans G. Buchholz Dipl.-Ing. Klinik und Poliklinik für Nuklearmedizin, Johannes Gutenberg Universität Mainz, 55131 Mainz, Germany, Fax: (+49) 6131-172386Search for more papers by this authorPeter Bartenstein Prof. Dr., Peter Bartenstein Prof. Dr. Klinik und Poliklinik für Nuklearmedizin, Johannes Gutenberg Universität Mainz, 55131 Mainz, Germany, Fax: (+49) 6131-172386Search for more papers by this authorBjörn Wängler Dr., Björn Wängler Dr. Abteilung für Radiopharmazeutische Chemie, Deutsches Krebsforschungszentrum Heidelberg, GermanySearch for more papers by this authorChristof M. Niemeyer Prof. Dr., Christof M. Niemeyer Prof. Dr. Lehrstuhl für Biologisch-Chemische Mikrostrukturtechnik, Universität Dortmund, GermanySearch for more papers by this authorKlaus Jurkschat Prof. Dr., Klaus Jurkschat Prof. Dr. [email protected] Lehrstuhl für Anorganische Chemie, Universität Dortmund, 44221 Dortmund, Germany, Fax: (+49) 231-755-5048Search for more papers by this author Ralf Schirrmacher Dr., Ralf Schirrmacher Dr. [email protected] Klinik und Poliklinik für Nuklearmedizin, Johannes Gutenberg Universität Mainz, 55131 Mainz, Germany, Fax: (+49) 6131-172386 These authors contributed equally.Search for more papers by this authorGerrit Bradtmöller Dipl.-Chem., Gerrit Bradtmöller Dipl.-Chem. Lehrstuhl für Anorganische Chemie, Universität Dortmund, 44221 Dortmund, Germany, Fax: (+49) 231-755-5048 These authors contributed equally.Search for more papers by this authorEsther Schirrmacher Dr., Esther Schirrmacher Dr. Klinik und Poliklinik für Nuklearmedizin, Johannes Gutenberg Universität Mainz, 55131 Mainz, Germany, Fax: (+49) 6131-172386 These authors contributed equally.Search for more papers by this authorOliver Thews Priv.-Doz. Dr., Oliver Thews Priv.-Doz. Dr. Institut für Physiology und Pathophysiologie, Universität Mainz, GermanySearch for more papers by this authorJulia Tillmanns, Julia Tillmanns Klinik und Poliklinik für Nuklearmedizin, Johannes Gutenberg Universität Mainz, 55131 Mainz, Germany, Fax: (+49) 6131-172386Search for more papers by this authorThomas Siessmeier Dr., Thomas Siessmeier Dr. Klinik und Poliklinik für Nuklearmedizin, Johannes Gutenberg Universität Mainz, 55131 Mainz, Germany, Fax: (+49) 6131-172386Search for more papers by this authorHans G. Buchholz Dipl.-Ing., Hans G. Buchholz Dipl.-Ing. Klinik und Poliklinik für Nuklearmedizin, Johannes Gutenberg Universität Mainz, 55131 Mainz, Germany, Fax: (+49) 6131-172386Search for more papers by this authorPeter Bartenstein Prof. Dr., Peter Bartenstein Prof. Dr. Klinik und Poliklinik für Nuklearmedizin, Johannes Gutenberg Universität Mainz, 55131 Mainz, Germany, Fax: (+49) 6131-172386Search for more papers by this authorBjörn Wängler Dr., Björn Wängler Dr. Abteilung für Radiopharmazeutische Chemie, Deutsches Krebsforschungszentrum Heidelberg, GermanySearch for more papers by this authorChristof M. Niemeyer Prof. Dr., Christof M. Niemeyer Prof. Dr. Lehrstuhl für Biologisch-Chemische Mikrostrukturtechnik, Universität Dortmund, GermanySearch for more papers by this authorKlaus Jurkschat Prof. Dr., Klaus Jurkschat Prof. Dr. [email protected] Lehrstuhl für Anorganische Chemie, Universität Dortmund, 44221 Dortmund, Germany, Fax: (+49) 231-755-5048Search for more papers by this author First published: 05 September 2006 https://doi.org/10.1002/anie.200600795Citations: 176 † This work was supported by the International Isotope Society Central European Division. The authors thank Philips for support and would like to thank Prof. Dr. H. J. Wester (TU Munich) for providing a protocol for oxime ligation. C.M.N. and G.B. acknowledge financial support from the Zentrum für Angewandte Chemische Genomik, a joint research initiative of the European Union and the Ministry of Innovation and Research of North Rhine-Westphalia. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Graphical Abstract F on: Fluorotriorganosilyl-derivatized Tyr3-octreotate was labeled with 18F− providing the first practical formulation in 18F-radiochemistry for the labeling of a peptide (see scheme). The very mild reaction conditions and the fast labeling make this strategy a valuable tool for the synthesis of 18F-radiopharmaceuticals. Supporting Information Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z600795_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. References 1“Chemistry of Fluorine-18 Radiopharmaceuticals”: S. E. Snyder, M. Kilbourn in Handbook of Radiopharmaceuticals, Radiochemistry and Applications (Eds.: ), Wiley, Chichester, 2003. 2T. Ido, C.-N. Wan, J. S. Fowler, A. P. Wolf, J. Org. Chem. 1977, 42, 2341. 3G. Firnau, C. Nahmias, E. S. Garnett, Int. J. Appl. Radiat. Isot. 1973, 24, 182. 4P. Blower, Dalton Trans. 2006, 1705. 5M. S. Rosenthal, A. L. Bosch, R. J. Nickles, S. J. Gatley, Int. J. Appl. Radiat. Isot. 1985, 36, 318. 6A. S. Pilcher, H. L. Ammon, P. DeSong, J. Am. Chem. Soc. 1995, 117, 5166. 7J. C. Walsh, K. M. 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Citing Literature Volume45, Issue36September 11, 2006Pages 6047-6050 ReferencesRelatedInformation
Publication Year: 2006
Publication Date: 2006-09-05
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 210
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