Publication Information

{'id': 'https://openalex.org/W2139024794', 'doi': 'https://doi.org/10.1016/j.mam.2012.06.007', 'title': 'The good, the bad and the ugly: Epigenetic mechanisms in glioblastoma', 'display_name': 'The good, the bad and the ugly: Epigenetic mechanisms in glioblastoma', 'publication_year': 2012, 'publication_date': '2012-07-05', 'ids': {'openalex': 'https://openalex.org/W2139024794', 'doi': 'https://doi.org/10.1016/j.mam.2012.06.007', 'mag': '2139024794', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22771539', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3714597'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.mam.2012.06.007', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S61794117', 'display_name': 'Molecular Aspects of Medicine', 'issn_l': '0098-2997', 'issn': ['0098-2997', '1872-9452'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/j.mam.2012.06.007', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5043787567', 'display_name': 'Helena Carén', 'orcid': 'https://orcid.org/0000-0002-8584-555X'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Helena Carén', 'raw_affiliation_strings': ['UCL Cancer Institute, University College London , 72 Huntley Street, London WC1E 6BT, United Kingdom.'], 'affiliations': [{'raw_affiliation_string': 'UCL Cancer Institute, University College London , 72 Huntley Street, London WC1E 6BT, United Kingdom.', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052128393', 'display_name': 'Steven M. Pollard', 'orcid': 'https://orcid.org/0000-0001-6428-0492'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Steven M. Pollard', 'raw_affiliation_strings': ['UCL Cancer Institute, University College London , 72 Huntley Street, London WC1E 6BT, United Kingdom.'], 'affiliations': [{'raw_affiliation_string': 'UCL Cancer Institute, University College London , 72 Huntley Street, London WC1E 6BT, United Kingdom.', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5017588786', 'display_name': 'Stephan Beck', 'orcid': 'https://orcid.org/0000-0001-5290-2151'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Stephan Beck', 'raw_affiliation_strings': ['UCL Cancer Institute, University College London , 72 Huntley Street, London WC1E 6BT, United Kingdom.'], 'affiliations': [{'raw_affiliation_string': 'UCL Cancer Institute, University College London , 72 Huntley Street, London WC1E 6BT, United Kingdom.', 'institution_ids': ['https://openalex.org/I45129253']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 5100, 'currency': 'USD', 'value_usd': 5100, 'provenance': 'doaj'}, 'apc_paid': {'value': 5100, 'currency': 'USD', 'value_usd': 5100, 'provenance': 'doaj'}, 'fwci': 0.59, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 48, 'citation_normalized_percentile': {'value': 0.659813, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '34', 'issue': '4', 'first_page': '849', 'last_page': '862'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10129', 'display_name': 'Glioma Diagnosis and Treatment', 'score': 0.9972, 'subfield': {'id': 'https://openalex.org/subfields/2716', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11736', 'display_name': 'Histone Deacetylase Inhibitors Research', 'score': 0.9965, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/epigenesis', 'display_name': 'Epigenesis', 'score': 0.42267638}], 'concepts': [{'id': 'https://openalex.org/C2776194525', 'wikidata': 'https://www.wikidata.org/wiki/Q282142', 'display_name': 'Glioblastoma', 'level': 2, 'score': 0.77543694}, {'id': 'https://openalex.org/C41091548', 'wikidata': 'https://www.wikidata.org/wiki/Q26939', 'display_name': 'Epigenetics', 'level': 3, 'score': 0.73071265}, {'id': 'https://openalex.org/C179463898', 'wikidata': 'https://www.wikidata.org/wiki/Q10273301', 'display_name': 'Epigenesis', 'level': 5, 'score': 0.42267638}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.39842907}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.37280262}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.3709072}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.36408022}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.33050114}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.32456148}, {'id': 'https://openalex.org/C15744967', 'wikidata': 'https://www.wikidata.org/wiki/Q9418', 'display_name': 'Psychology', 'level': 0, 'score': 0.32359678}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.17230237}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.12900731}], 'mesh': [{'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001932', 'descriptor_name': 'Brain Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D063646', 'descriptor_name': 'Carcinogenesis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002454', 'descriptor_name': 'Cell Differentiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042002', 'descriptor_name': 'Chromatin Assembly and Disassembly', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044127', 'descriptor_name': 'Epigenesis, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005909', 'descriptor_name': 'Glioblastoma', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058990', 'descriptor_name': 'Molecular Targeted Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014411', 'descriptor_name': 'Neoplastic Stem Cells', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.mam.2012.06.007', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S61794117', 'display_name': 'Molecular Aspects of Medicine', 'issn_l': '0098-2997', 'issn': ['0098-2997', '1872-9452'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3714597', 'pdf_url': 'https://europepmc.org/articles/pmc3714597?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.pure.ed.ac.uk/ws/files/12908159/The_good_the_bad_and_the_ugly.pdf', 'pdf_url': 'https://www.pure.ed.ac.uk/ws/files/12908159/The_good_the_bad_and_the_ugly.pdf', 'source': {'id': 'https://openalex.org/S4306400320', 'display_name': 'Edinburgh Research Explorer (University of Edinburgh)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I98677209', 'host_organization_name': 'University of Edinburgh', 'host_organization_lineage': ['https://openalex.org/I98677209'], 'host_organization_lineage_names': ['University of Edinburgh'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/20.500.11820/9497d809-50f6-4b43-9ca4-df18b4f830c7', 'pdf_url': 'https://www.research.ed.ac.uk/files/12908159/The_good_the_bad_and_the_ugly.pdf', 'source': {'id': 'https://openalex.org/S4306400320', 'display_name': 'Edinburgh Research Explorer (University of Edinburgh)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I98677209', 'host_organization_name': 'University of Edinburgh', 'host_organization_lineage': ['https://openalex.org/I98677209'], 'host_organization_lineage_names': ['University of Edinburgh'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714597', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22771539', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.mam.2012.06.007', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S61794117', 'display_name': 'Molecular Aspects of Medicine', 'issn_l': '0098-2997', 'issn': ['0098-2997', '1872-9452'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 127, 'referenced_works': ['https://openalex.org/W147520654', 'https://openalex.org/W1492600479', 'https://openalex.org/W1504303645', 'https://openalex.org/W1516326873', 'https://openalex.org/W1588444780', 'https://openalex.org/W1595888719', 'https://openalex.org/W1682181752', 'https://openalex.org/W1963781146', 'https://openalex.org/W1964096828', 'https://openalex.org/W1964545612', 'https://openalex.org/W1966135244', 'https://openalex.org/W1967725040', 'https://openalex.org/W1969670934', 'https://openalex.org/W1972218893', 'https://openalex.org/W1974689368', 'https://openalex.org/W1974747095', 'https://openalex.org/W1979892065', 'https://openalex.org/W1981543052', 'https://openalex.org/W1982649435', 'https://openalex.org/W1986072799', 'https://openalex.org/W1987753375', 'https://openalex.org/W1988756388', 'https://openalex.org/W1989615169', 'https://openalex.org/W1997453048', 'https://openalex.org/W1997656997', 'https://openalex.org/W1999356404', 'https://openalex.org/W1999513100', 'https://openalex.org/W2000924030', 'https://openalex.org/W2001176921', 'https://openalex.org/W2007448778', 'https://openalex.org/W2008758335', 'https://openalex.org/W2010054551', 'https://openalex.org/W2011376261', 'https://openalex.org/W2011845911', 'https://openalex.org/W2013284753', 'https://openalex.org/W2018671779', 'https://openalex.org/W2019237526', 'https://openalex.org/W2020138426', 'https://openalex.org/W2020170592', 'https://openalex.org/W2021577923', 'https://openalex.org/W2022985713', 'https://openalex.org/W2024985626', 'https://openalex.org/W2025183726', 'https://openalex.org/W2028078153', 'https://openalex.org/W2031502815', 'https://openalex.org/W2034269086', 'https://openalex.org/W2035151737', 'https://openalex.org/W2036986058', 'https://openalex.org/W2038449573', 'https://openalex.org/W2038756976', 'https://openalex.org/W2040827479', 'https://openalex.org/W2041442332', 'https://openalex.org/W2042012963', 'https://openalex.org/W2043033879', 'https://openalex.org/W2043933892', 'https://openalex.org/W2044670492', 'https://openalex.org/W2046069528', 'https://openalex.org/W2046878942', 'https://openalex.org/W2050969887', 'https://openalex.org/W2059099579', 'https://openalex.org/W2061891352', 'https://openalex.org/W2062062519', 'https://openalex.org/W2062357183', 'https://openalex.org/W2065435622', 'https://openalex.org/W2065691894', 'https://openalex.org/W2070945812', 'https://openalex.org/W2071115015', 'https://openalex.org/W2074765580', 'https://openalex.org/W2078972833', 'https://openalex.org/W2080838269', 'https://openalex.org/W2081758137', 'https://openalex.org/W2082131511', 'https://openalex.org/W2083522244', 'https://openalex.org/W2083535257', 'https://openalex.org/W2086575542', 'https://openalex.org/W2086857599', 'https://openalex.org/W2087846605', 'https://openalex.org/W2088708165', 'https://openalex.org/W2091151146', 'https://openalex.org/W2093189184', 'https://openalex.org/W2094743676', 'https://openalex.org/W2096670842', 'https://openalex.org/W2098785952', 'https://openalex.org/W2100795816', 'https://openalex.org/W2102085111', 'https://openalex.org/W2104419412', 'https://openalex.org/W2104633297', 'https://openalex.org/W2105528101', 'https://openalex.org/W2108630708', 'https://openalex.org/W2108664872', 'https://openalex.org/W2111013340', 'https://openalex.org/W2112054486', 'https://openalex.org/W2112442017', 'https://openalex.org/W2112495947', 'https://openalex.org/W2113633164', 'https://openalex.org/W2113942802', 'https://openalex.org/W2118681186', 'https://openalex.org/W2121417064', 'https://openalex.org/W2124078079', 'https://openalex.org/W2127016346', 'https://openalex.org/W2128064256', 'https://openalex.org/W2128146359', 'https://openalex.org/W2129387595', 'https://openalex.org/W2135832165', 'https://openalex.org/W2138859400', 'https://openalex.org/W2140317067', 'https://openalex.org/W2143658931', 'https://openalex.org/W2144936572', 'https://openalex.org/W2146194207', 'https://openalex.org/W2147415859', 'https://openalex.org/W2147518722', 'https://openalex.org/W2148521032', 'https://openalex.org/W2150515158', 'https://openalex.org/W2150575159', 'https://openalex.org/W2151311897', 'https://openalex.org/W2152387543', 'https://openalex.org/W2152451432', 'https://openalex.org/W2154313451', 'https://openalex.org/W2155725346', 'https://openalex.org/W2158233796', 'https://openalex.org/W2161289668', 'https://openalex.org/W2165541556', 'https://openalex.org/W2167650288', 'https://openalex.org/W2170210082', 'https://openalex.org/W2171141282', 'https://openalex.org/W2595704730', 'https://openalex.org/W2739174192'], 'related_works': ['https://openalex.org/W4379517748', 'https://openalex.org/W3212149434', 'https://openalex.org/W2488545743', 'https://openalex.org/W2306525395', 'https://openalex.org/W2291484187', 'https://openalex.org/W2214376880', 'https://openalex.org/W2148506810', 'https://openalex.org/W2073893804', 'https://openalex.org/W2031458863', 'https://openalex.org/W2022797399'], 'abstract_inverted_index': {'Cell': [0], 'type-specific': [1], 'patterns': [2], 'of': [3, 38, 67, 90, 106, 111, 151], 'gene': [4], 'expression': [5], 'reflect': [6], 'epigenetic': [7, 39, 68, 93, 115, 124, 152], 'changes': [8], 'imposed': [9], 'through': [10], 'a': [11], 'particular': [12], 'developmental': [13], 'lineage': [14], 'as': [15, 17, 99], 'well': [16], 'those': [18], 'triggered': [19], 'by': [20, 101, 127], 'environmental': [21], 'cues': [22], 'within': [23, 121, 132], 'adult': [24, 75], 'tissues.': [25], 'There': [26], 'is': [27], 'great': [28], 'interest': [29], 'in': [30, 41, 49, 65, 70, 88, 154], 'elucidating': [31], 'the': [32, 71, 86, 107, 122, 128, 144, 146, 149], 'molecular': [33], 'basis': [34], 'and': [35, 45, 113, 137, 148], 'functional': [36], 'importance': [37], 'mechanisms': [40, 69, 153], 'both': [42], 'normal': [43], 'physiology': [44], 'disease': [46], '–': [47, 98], 'particularly': [48], 'cancer,': [50, 77], 'where': [51], 'abnormal': [52], "'-omic'": [53], 'states': [54], 'are': [55, 83], 'often': [56], 'observed.': [57], 'In': [58], 'this': [59], 'article': [60], 'we': [61], 'review': [62], 'recent': [63], 'progress': [64], 'studies': [66], 'most': [72], 'common': [73], 'primary': [74], 'brain': [76], 'glioblastoma': [78], 'multiforme.': [79], 'Three': [80], 'distinct': [81], 'areas': [82], 'discussed.': [84], 'First,': [85], 'evidence': [87], 'support': [89], 'ongoing': [91], "'normal'": [92], 'processes': [94], 'associated': [95], 'with': [96], 'differentiation': [97], 'predicted': [100], "'cancer": [102], 'stem': [103], "cell'": [104], 'models': [105], 'disease.': [108], 'Second,': [109], 'identification': [110], 'site-specific': [112], 'global': [114], 'abnormalities.': [116], 'Third,': [117], 'genetic': [118], 'disruptions': [119], 'directly': [120], 'core': [123], 'machinery,': [125], 'exemplified': [126], 'recently': [129], 'identified': [130], 'mutations': [131], 'isocitrate': [133], 'dehydrogenase': [134], 'genes': [135, 140], 'IDH1/2': [136], 'variant': [138], 'histone': [139], 'H3.3/H3F3A.': [141], 'These': [142], 'constitute': [143], "'good,": [145], 'bad': [147], "ugly'": [150], 'cancer.': [155]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2139024794', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 6}], 'updated_date': '2024-12-17T17:39:42.659517', 'created_date': '2016-06-24'}