Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2138946261', 'doi': 'https://doi.org/10.1128/mcb.26.5.1700-1709.2006', 'title': 'Targeted Disruption of Fibulin-4 Abolishes Elastogenesis and Causes Perinatal Lethality in Mice', 'display_name': 'Targeted Disruption of Fibulin-4 Abolishes Elastogenesis and Causes Perinatal Lethality in Mice', 'publication_year': 2006, 'publication_date': '2006-02-14', 'ids': {'openalex': 'https://openalex.org/W2138946261', 'doi': 'https://doi.org/10.1128/mcb.26.5.1700-1709.2006', 'mag': '2138946261', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/16478991', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/1430262'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/mcb.26.5.1700-1709.2006', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S81455967', 'display_name': 'Molecular and Cellular Biology', 'issn_l': '0270-7306', 'issn': ['0270-7306', '1067-8824', '1098-5549'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc1430262?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5038200275', 'display_name': 'P. J. McLaughlin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Precious J. McLaughlin', 'raw_affiliation_strings': ['Department of Ophthalmology and Vision Science, University of Arizona, Tucson, AZ 85711, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology and Vision Science, University of Arizona, Tucson, AZ 85711, USA.', 'institution_ids': ['https://openalex.org/I138006243']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101527286', 'display_name': 'Qiuyun Chen', 'orcid': 'https://orcid.org/0000-0002-3645-400X'}, 'institutions': [{'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Qiuyun Chen', 'raw_affiliation_strings': ['Department of Ophthalmology and Vision Science', 'University of Arizona'], 'affiliations': [{'raw_affiliation_string': 'University of Arizona', 'institution_ids': ['https://openalex.org/I138006243']}, {'raw_affiliation_string': 'Department of Ophthalmology and Vision Science', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049918593', 'display_name': 'Masahito Horiguchi', 'orcid': 'https://orcid.org/0000-0001-5325-3931'}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Masahito Horiguchi', 'raw_affiliation_strings': ['Horizontal Medical Research Organization, Kyoto University School of Medicine, Kyoto, Japan'], 'affiliations': [{'raw_affiliation_string': 'Horizontal Medical Research Organization, Kyoto University School of Medicine, Kyoto, Japan', 'institution_ids': ['https://openalex.org/I22299242']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064199032', 'display_name': 'Barry Starcher', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I90436673', 'display_name': 'The University of Texas Health Science Center at Tyler', 'ror': 'https://ror.org/01sps7q28', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I90436673']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Barry C. Starcher', 'raw_affiliation_strings': ['Department of Biochemistry, University of Texas Health Center at Tyler, Texas'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, University of Texas Health Center at Tyler, Texas', 'institution_ids': ['https://openalex.org/I90436673']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074366302', 'display_name': 'J. Brett Stanton', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J. Brett Stanton', 'raw_affiliation_strings': ['Department of Ophthalmology and Vision Science', 'University of Arizona'], 'affiliations': [{'raw_affiliation_string': 'University of Arizona', 'institution_ids': ['https://openalex.org/I138006243']}, {'raw_affiliation_string': 'Department of Ophthalmology and Vision Science', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016948672', 'display_name': 'Thomas J. Broekelmann', 'orcid': 'https://orcid.org/0000-0002-5563-6538'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Thomas J. Broekelmann', 'raw_affiliation_strings': ['Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017937304', 'display_name': 'Alan D. Marmorstein', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210122332', 'display_name': 'Optical Sciences (United States)', 'ror': 'https://ror.org/03122yk49', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210122332']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Alan D. Marmorstein', 'raw_affiliation_strings': ['Department of Ophthalmology and Vision Science,', 'Optical Sciences Center'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology and Vision Science,', 'institution_ids': []}, {'raw_affiliation_string': 'Optical Sciences Center', 'institution_ids': ['https://openalex.org/I4210122332']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069191572', 'display_name': 'Brian S. McKay', 'orcid': 'https://orcid.org/0000-0002-2893-3959'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Brian McKay', 'raw_affiliation_strings': ['Department of Cell Biology and Anatomy', 'Department of Ophthalmology and Vision Science'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology and Vision Science', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Cell Biology and Anatomy', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068418680', 'display_name': 'Robert P. Mecham', 'orcid': 'https://orcid.org/0000-0002-4020-9277'}, 'institutions': [{'id': 'https://openalex.org/I204465549', 'display_name': 'Washington University in St. Louis', 'ror': 'https://ror.org/01yc7t268', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I204465549']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert Mecham', 'raw_affiliation_strings': ['Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri', 'institution_ids': ['https://openalex.org/I204465549']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101598815', 'display_name': 'Tomoyuki Nakamura', 'orcid': 'https://orcid.org/0000-0002-8017-9818'}, 'institutions': [{'id': 'https://openalex.org/I22299242', 'display_name': 'Kyoto University', 'ror': 'https://ror.org/02kpeqv85', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I22299242']}], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Tomoyuki Nakamura', 'raw_affiliation_strings': ['Horizontal Medical Research Organization, Kyoto University School of Medicine, Kyoto, Japan'], 'affiliations': [{'raw_affiliation_string': 'Horizontal Medical Research Organization, Kyoto University School of Medicine, Kyoto, Japan', 'institution_ids': ['https://openalex.org/I22299242']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5049420555', 'display_name': 'Lihua Y. Marmorstein', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I138006243', 'display_name': 'University of Arizona', 'ror': 'https://ror.org/03m2x1q45', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I138006243']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lihua Y. Marmorstein', 'raw_affiliation_strings': ['Department of Ophthalmology and Vision Science', 'Department of Physiology, University of Arizona, Tucson, Arizona'], 'affiliations': [{'raw_affiliation_string': 'Department of Ophthalmology and Vision Science', 'institution_ids': []}, {'raw_affiliation_string': 'Department of Physiology, University of Arizona, Tucson, Arizona', 'institution_ids': ['https://openalex.org/I138006243', 'https://openalex.org/I138006243']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 8.132, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 199, 'citation_normalized_percentile': {'value': 0.999942, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '26', 'issue': '5', 'first_page': '1700', 'last_page': '1709'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11310', 'display_name': 'Genetic and Molecular Studies of Connective Tissue Disorders', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11310', 'display_name': 'Genetic and Molecular Studies of Connective Tissue Disorders', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12688', 'display_name': 'Biological Methane Utilization and Metabolism', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12924', 'display_name': 'Genetic Disorders Causing Tissue Mineralization Abnormalities', 'score': 0.9833, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/fibulin', 'display_name': 'Fibulin', 'score': 0.99417496}, {'id': 'https://openalex.org/keywords/tropoelastin', 'display_name': 'Tropoelastin', 'score': 0.9838277}, {'id': 'https://openalex.org/keywords/elastic-fiber', 'display_name': 'Elastic fiber', 'score': 0.9169345}, {'id': 'https://openalex.org/keywords/lysyl-oxidase', 'display_name': 'Lysyl oxidase', 'score': 0.87480253}, {'id': 'https://openalex.org/keywords/desmosine', 'display_name': 'Desmosine', 'score': 0.7770158}, {'id': 'https://openalex.org/keywords/fibrillin-1', 'display_name': 'Fibrillin-1', 'score': 0.512236}], 'concepts': [{'id': 'https://openalex.org/C2778122751', 'wikidata': 'https://www.wikidata.org/wiki/Q5446488', 'display_name': 'Fibulin', 'level': 3, 'score': 0.99417496}, {'id': 'https://openalex.org/C2780299668', 'wikidata': 'https://www.wikidata.org/wiki/Q409747', 'display_name': 'Tropoelastin', 'level': 3, 'score': 0.9838277}, {'id': 'https://openalex.org/C2779869378', 'wikidata': 'https://www.wikidata.org/wiki/Q409747', 'display_name': 'Elastin', 'level': 2, 'score': 0.9787017}, {'id': 'https://openalex.org/C2780028357', 'wikidata': 'https://www.wikidata.org/wiki/Q259817', 'display_name': 'Elastic fiber', 'level': 2, 'score': 0.9169345}, {'id': 'https://openalex.org/C193143273', 'wikidata': 'https://www.wikidata.org/wiki/Q419389', 'display_name': 'Lysyl oxidase', 'level': 3, 'score': 0.87480253}, {'id': 'https://openalex.org/C2780638554', 'wikidata': 'https://www.wikidata.org/wiki/Q61184', 'display_name': 'Desmosine', 'level': 3, 'score': 0.7770158}, {'id': 'https://openalex.org/C189165786', 'wikidata': 'https://www.wikidata.org/wiki/Q193825', 'display_name': 'Extracellular matrix', 'level': 2, 'score': 0.59864193}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.43402293}, {'id': 'https://openalex.org/C2779980429', 'wikidata': 'https://www.wikidata.org/wiki/Q101004', 'display_name': 'Aorta', 'level': 2, 'score': 0.42822966}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3935259}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.38413575}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.37566465}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.17179066}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.12264308}], 'mesh': [{'descriptor_ui': 'D004547', 'descriptor_name': 'Elastic Tissue', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D016326', 'descriptor_name': 'Extracellular Matrix Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D016326', 'descriptor_name': 'Extracellular Matrix Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D005313', 'descriptor_name': 'Fetal Death', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001011', 'descriptor_name': 'Aorta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001011', 'descriptor_name': 'Aorta', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': False}, {'descriptor_ui': 'D001011', 'descriptor_name': 'Aorta', 'qualifier_ui': 'Q000002', 'qualifier_name': 'abnormalities', 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003895', 'descriptor_name': 'Desmosine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003895', 'descriptor_name': 'Desmosine', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004547', 'descriptor_name': 'Elastic Tissue', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004547', 'descriptor_name': 'Elastic Tissue', 'qualifier_ui': 'Q000002', 'qualifier_name': 'abnormalities', 'is_major_topic': False}, {'descriptor_ui': 'D004549', 'descriptor_name': 'Elastin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004549', 'descriptor_name': 'Elastin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016326', 'descriptor_name': 'Extracellular Matrix Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005313', 'descriptor_name': 'Fetal Death', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D020868', 'descriptor_name': 'Gene Silencing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008168', 'descriptor_name': 'Lung', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008168', 'descriptor_name': 'Lung', 'qualifier_ui': 'Q000002', 'qualifier_name': 'abnormalities', 'is_major_topic': False}, {'descriptor_ui': 'D008168', 'descriptor_name': 'Lung', 'qualifier_ui': 'Q000196', 'qualifier_name': 'embryology', 'is_major_topic': False}, {'descriptor_ui': 'D008168', 'descriptor_name': 'Lung', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008817', 'descriptor_name': 'Mice, Mutant Strains', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008249', 'descriptor_name': 'Protein-Lysine 6-Oxidase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008249', 'descriptor_name': 'Protein-Lysine 6-Oxidase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014333', 'descriptor_name': 'Tropoelastin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014333', 'descriptor_name': 'Tropoelastin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1128/mcb.26.5.1700-1709.2006', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S81455967', 'display_name': 'Molecular and Cellular Biology', 'issn_l': '0270-7306', 'issn': ['0270-7306', '1067-8824', '1098-5549'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1430262', 'pdf_url': 'https://europepmc.org/articles/pmc1430262?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=3379&context=open_access_pubs', 'pdf_url': 'https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=3379&context=open_access_pubs', 'source': {'id': 'https://openalex.org/S4377196288', 'display_name': 'Digital Commons - Becker (Washington University in St. Louis)', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I204465549', 'host_organization_name': 'Washington University in St. Louis', 'host_organization_lineage': ['https://openalex.org/I204465549'], 'host_organization_lineage_names': ['Washington University in St. Louis'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1430262', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/16478991', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc1430262', 'pdf_url': 'https://europepmc.org/articles/pmc1430262?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.71, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 59, 'referenced_works': ['https://openalex.org/W1504680742', 'https://openalex.org/W1563557384', 'https://openalex.org/W1564135085', 'https://openalex.org/W1653019055', 'https://openalex.org/W175967323', 'https://openalex.org/W1963855416', 'https://openalex.org/W1971412135', 'https://openalex.org/W1973989747', 'https://openalex.org/W1975860498', 'https://openalex.org/W1980094415', 'https://openalex.org/W1986803290', 'https://openalex.org/W1986897852', 'https://openalex.org/W1987191756', 'https://openalex.org/W1992319305', 'https://openalex.org/W1992781479', 'https://openalex.org/W1993744211', 'https://openalex.org/W1999347645', 'https://openalex.org/W2000044234', 'https://openalex.org/W2004600332', 'https://openalex.org/W2005270333', 'https://openalex.org/W2009738449', 'https://openalex.org/W2014725746', 'https://openalex.org/W2019002861', 'https://openalex.org/W2023021766', 'https://openalex.org/W2023319309', 'https://openalex.org/W2026388693', 'https://openalex.org/W2027739263', 'https://openalex.org/W2034356701', 'https://openalex.org/W2054292017', 'https://openalex.org/W2057328263', 'https://openalex.org/W2059292090', 'https://openalex.org/W2062395208', 'https://openalex.org/W2062731252', 'https://openalex.org/W2064703228', 'https://openalex.org/W2067202687', 'https://openalex.org/W2084311974', 'https://openalex.org/W2096201017', 'https://openalex.org/W2097762351', 'https://openalex.org/W2099255034', 'https://openalex.org/W2099319821', 'https://openalex.org/W2110835444', 'https://openalex.org/W2122243862', 'https://openalex.org/W2122935525', 'https://openalex.org/W2124892358', 'https://openalex.org/W2129120732', 'https://openalex.org/W2144356448', 'https://openalex.org/W2150459172', 'https://openalex.org/W2151162458', 'https://openalex.org/W2160514176', 'https://openalex.org/W2161561755', 'https://openalex.org/W2399550214', 'https://openalex.org/W2417831017', 'https://openalex.org/W2484113633', 'https://openalex.org/W303341122', 'https://openalex.org/W3150202998', 'https://openalex.org/W4210961984', 'https://openalex.org/W4211236610', 'https://openalex.org/W4252440165', 'https://openalex.org/W571245376'], 'related_works': ['https://openalex.org/W4213275908', 'https://openalex.org/W2760741480', 'https://openalex.org/W2117633159', 'https://openalex.org/W2111563692', 'https://openalex.org/W2077701521', 'https://openalex.org/W2040634445', 'https://openalex.org/W2028007500', 'https://openalex.org/W2019002861', 'https://openalex.org/W1999029019', 'https://openalex.org/W1977589070'], 'abstract_inverted_index': {'Elastic': [0], 'fibers': [1, 119, 187], 'provide': [2], 'tissues': [3, 160], 'with': [4, 181, 185], 'elasticity': [5, 21], 'which': [6], 'is': [7, 22, 39], 'critical': [8], 'to': [9, 144], 'the': [10, 31, 76, 89, 128, 145], 'function': [11], 'of': [12, 20, 33, 46, 88, 148, 165], 'arteries,': [13], 'lungs,': [14], 'skin,': [15], 'and': [16, 29, 37, 63, 73, 102, 183], 'other': [17], 'dynamic': [18], 'organs.Loss': [19], 'a': [23, 85], 'major': [24], 'contributing': [25], 'factor': [26], 'in': [27, 92, 134, 142, 157, 173, 188, 198], 'aging': [28], 'diseases.However,': [30], 'mechanism': [32], 'elastic': [34, 118, 150, 186], 'fiber': [35], 'development': [36], 'assembly': [38], 'poorly': [40], 'understood.Here,': [41], 'we': [42], 'show': [43], 'that': [44, 110, 127, 135, 154, 192], 'lack': [45], 'fibulin-4,': [47], 'an': [48, 195], 'extracellular': [49], 'matrix': [50], 'molecule,': [51], 'abolishes': [52], 'elastogenesis.fibulin-4': [53], '؊/؊': [54, 94, 112, 159, 175], 'mice': [55, 78, 113], 'generated': [56], 'by': [57], 'gene': [58], 'targeting': [59], 'exhibited': [60], 'severe': [61], 'lung': [62], 'vascular': [64], 'defects': [65], 'including': [66], 'emphysema,': [67], 'artery': [68], 'tortuosity,': [69], 'irregularity,': [70], 'aneurysm,': [71], 'rupture,': [72], 'resulting': [74], 'hemorrhages.All': [75], 'homozygous': [77], 'died': [79], 'perinatally.The': [80], 'earliest': [81], 'abnormality': [82], 'noted': [83], 'was': [84, 171], 'uniformly': [86], 'narrowing': [87], 'descending': [90], 'aorta': [91], 'fibulin-4': [93, 111, 158, 174, 178, 193], 'embryos': [95], 'at': [96, 106], 'embryonic': [97], 'day': [98], '12.5': [99], '(E12.5).Aorta': [100], 'tortuosity': [101], 'irregularity': [103], 'became': [104], 'noticeable': [105], 'E15.5.Histological': [107], 'analysis': [108, 152], 'demonstrated': [109], 'do': [114], 'not': [115], 'develop': [116], 'intact': [117], 'but': [120], 'contain': [121, 137], 'irregular': [122], 'elastin': [123, 129, 155], 'aggregates.Electron': [124], 'microscopy': [125], 'revealed': [126], 'aggregates': [130], 'are': [131], 'highly': [132], 'unusual': [133], 'they': [136], 'evenly': [138], 'distributed': [139], 'rod-like': [140], 'filaments,': [141], 'contrast': [143], 'amorphous': [146], 'appearance': [147], 'normal': [149], 'fibers.Desmosine': [151], 'indicated': [153], 'cross-links': [156], 'were': [161], 'largely': [162], 'diminished.However,': [163], 'expression': [164], 'tropoelastin': [166, 182], 'or': [167], 'lysyl': [168], 'oxidase': [169], 'mRNA': [170], 'unaffected': [172], 'mice.In': [176], 'addition,': [177], 'strongly': [179], 'interacts': [180], 'colocalizes': [184], 'culture.These': [189], 'results': [190], 'demonstrate': [191], 'plays': [194], 'irreplaceable': [196], 'role': [197], 'elastogenesis.': [199]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2138946261', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 8}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 12}, {'year': 2015, 'cited_by_count': 10}, {'year': 2014, 'cited_by_count': 16}, {'year': 2013, 'cited_by_count': 11}, {'year': 2012, 'cited_by_count': 11}], 'updated_date': '2024-09-17T16:34:30.111840', 'created_date': '2016-06-24'}