Publication Information

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'https://openalex.org/W1564861448', 'https://openalex.org/W1568020570', 'https://openalex.org/W1599277155', 'https://openalex.org/W1650401181', 'https://openalex.org/W1678757150', 'https://openalex.org/W1745534060', 'https://openalex.org/W1964103059', 'https://openalex.org/W1982706640', 'https://openalex.org/W1984687894', 'https://openalex.org/W1984829055', 'https://openalex.org/W1984843607', 'https://openalex.org/W1993818203', 'https://openalex.org/W1999224438', 'https://openalex.org/W2004493226', 'https://openalex.org/W2008329814', 'https://openalex.org/W2008801811', 'https://openalex.org/W2009654376', 'https://openalex.org/W2010490694', 'https://openalex.org/W2029381793', 'https://openalex.org/W2030967912', 'https://openalex.org/W2034525269', 'https://openalex.org/W2045488843', 'https://openalex.org/W2050407677', 'https://openalex.org/W2056244739', 'https://openalex.org/W2062061647', 'https://openalex.org/W2088093088', 'https://openalex.org/W2093873733', 'https://openalex.org/W2104236972', 'https://openalex.org/W2117226055', 'https://openalex.org/W2125551363', 'https://openalex.org/W2130400575', 'https://openalex.org/W2135011583', 'https://openalex.org/W2144470409', 'https://openalex.org/W2153331570', 'https://openalex.org/W2154409881', 'https://openalex.org/W2154778779', 'https://openalex.org/W2160385558', 'https://openalex.org/W2162369109', 'https://openalex.org/W2163411441', 'https://openalex.org/W2442017598', 'https://openalex.org/W24968931'], 'related_works': ['https://openalex.org/W975796270', 'https://openalex.org/W4255716900', 'https://openalex.org/W2337457843', 'https://openalex.org/W2086348707', 'https://openalex.org/W2083639640', 'https://openalex.org/W2064525306', 'https://openalex.org/W2063903820', 'https://openalex.org/W2050002814', 'https://openalex.org/W2041391472', 'https://openalex.org/W2038949756'], 'abstract_inverted_index': {'Recent': [0, 177, 390], 'studies': [1, 178, 3063, 3783, 4008], 'indicate': [2, 179, 3064, 3382], 'novel': [3, 162, 180, 339], 'roles': [4, 181], 'for': [5, 164, 182, 341, 398, 536, 1027, 1485, 1533, 1557, 1688, 1715, 1729, 1763, 1884, 2044, 2106, 2126, 2161, 2209, 2235, 2318, 2385, 2426, 2768, 2837, 3159, 3188, 3621, 3627, 3657, 3789, 3815, 3958], 'the': [6, 32, 71, 120, 126, 183, 209, 248, 297, 303, 508, 527, 539, 706, 736, 751, 758, 775, 791, 801, 921, 936, 942, 997, 1000, 1060, 1129, 1362, 1750, 1764, 1779, 1782, 1792, 1806, 1843, 1885, 1934, 1967, 2048, 2060, 2069, 2087, 2115, 2230, 2356, 2386, 2392, 2503, 2526, 2536, 2624, 2684, 2699, 2702, 2935, 2985, 3003, 3015, 3033, 3038, 3155, 3160, 3245, 3248, 3256, 3267, 3270, 3275, 3278, 3333, 3446, 3477, 3526, 3555, 3563, 3571, 3576, 3638, 3654, 3824, 3847, 3850, 3877, 3896, 3933, 3940, 3983, 3995, 3998, 4013, 4051, 4056, 4081, 4176, 4225, 4229, 4245], 'ubiquitous': [7, 184], 'ion': [8, 171, 185, 348], 'pump,': [9, 186], 'Na,K-ATPase,': [10, 36, 187, 213, 3531, 3830], 'in': [11, 70, 79, 145, 188, 247, 256, 322, 361, 538, 744, 767, 808, 1077, 1289, 1642, 1771, 1786, 1791, 1796, 1892, 2030, 2068, 2110, 2133, 2355, 2394, 2413, 2502, 2506, 2522, 2532, 2560, 2566, 2618, 2623, 2674, 2733, 2756, 2772, 2853, 3002, 3242, 3261, 3281, 3286, 3320, 3329, 3396, 3432, 3570, 3758, 3805, 3818, 3860, 3922, 3947, 4022, 4027, 4034, 4055, 4105, 4158], 'addition': [12, 189, 2854], 'to': [13, 190, 394, 526, 685, 773, 912, 978, 1008, 1095, 1140, 1951, 2002, 2007, 2097, 2193, 2212, 2295, 2329, 2391, 2418, 2621, 2662, 2682, 2845, 2855, 2865, 2913, 2974, 3032, 3230, 3393, 3525, 3706, 3846, 3938, 4012, 4098, 4169, 4243], 'its': [14, 191, 764, 2856], 'function': [15, 192, 3067, 4227], 'as': [16, 174, 193, 351, 368, 400, 554, 724, 783, 1234, 1414, 1618, 1648, 1701, 2374, 2382, 2434, 2807, 3482, 3533, 3554, 3763, 4152], 'a': [17, 42, 47, 65, 91, 161, 165, 175, 194, 219, 224, 242, 268, 338, 342, 352, 369, 401, 502, 592, 754, 784, 809, 1052, 1183, 1267, 1278, 1495, 1511, 1629, 1736, 1787, 1825, 1835, 1959, 2031, 2111, 2119, 2178, 2195, 2226, 2242, 2251, 2261, 2308, 2322, 2375, 2395, 2439, 2500, 2539, 2551, 2717, 2808, 2924, 3169, 3172, 3294, 3360, 3454, 3547, 3631, 3716, 3885, 3977, 4023, 4047, 4065], 'key': [18, 195, 370], 'regulator': [19, 196, 371], 'of': [20, 35, 50, 73, 119, 125, 129, 139, 155, 197, 212, 227, 250, 296, 302, 306, 316, 332, 372, 510, 515, 529, 541, 687, 694, 705, 753, 760, 793, 804, 920, 933, 935, 944, 982, 999, 1012, 1042, 1059, 1101, 1112, 1133, 1222, 1229, 1498, 1513, 1747, 1759, 1767, 1814, 1842, 1969, 2080, 2086, 2201, 2222, 2359, 2438, 2441, 2525, 2538, 2583, 2676, 2701, 2811, 2839, 2911, 2915, 2927, 2934, 2977, 2987, 3005, 3018, 3025, 3042, 3049, 3058, 3157, 3233, 3244, 3255, 3266, 3277, 3298, 3356, 3408, 3480, 3530, 3575, 3720, 3737, 3802, 3826, 3849, 3888, 3891, 3898, 3979, 3982, 4039, 4050, 4068, 4074, 4083, 4096, 4228], 'intracellular': [21, 39, 44, 198, 216, 221, 373, 699, 2496, 2706, 2740], 'sodium': [22, 199, 2145], 'and': [23, 58, 97, 105, 110, 136, 151, 200, 235, 274, 282, 287, 313, 328, 375, 702, 710, 731, 763, 806, 907, 993, 1017, 1025, 1038, 1087, 1117, 1219, 1275, 1387, 1398, 1402, 1409, 1477, 1517, 1521, 1539, 1551, 1691, 1718, 1745, 1794, 1889, 1989, 2010, 2017, 2020, 2040, 2051, 2056, 2072, 2092, 2159, 2184, 2285, 2291, 2316, 2343, 2362, 2399, 2411, 2424, 2430, 2452, 2528, 2543, 2576, 3020, 3056, 3194, 3300, 3415, 3419, 3426, 3451, 3565, 3623, 3632, 3640, 3644, 3662, 3712, 3717, 3722, 3726, 3732, 3741, 3746, 3792, 3798, 3809, 3858, 3863, 3882, 3893, 3932, 3952, 3972, 3989, 3993, 4003, 4017, 4092, 4107, 4151, 4166], 'potassium': [24, 201], 'concentration.': [25, 202], 'We': [26, 203, 589], 'have': [27, 204, 533, 547, 590, 2764], 'previously': [28, 205, 1416, 1650], 'demonstrated': [29, 206, 4104], 'that': [30, 56, 207, 233, 505, 549, 683, 689, 717, 720, 732, 790, 1954, 2215, 2970, 2996, 3023, 3065, 3354, 3383, 3637, 3876, 3968, 3997, 4015, 4041, 4172], 'ouabain,': [31, 74, 208, 251, 501, 1378, 2575], 'endogenous': [33, 210, 499], 'ligand': [34, 211, 1167], 'can': [37, 214, 781, 1846], 'trigger': [38, 215], 'Ca2+': [40, 77, 112, 134, 142, 217, 254, 289, 311, 319, 647, 671, 700, 721, 729, 733, 794, 830, 864, 1401, 2497, 2512, 2553, 2562, 2668, 2690, 2703, 2710, 2720, 2731, 2737, 2742, 2770, 2841, 2861, 2870, 2998, 3026, 3034, 3162, 3197, 3240, 3284, 3318, 3345, 3366, 3376, 3385], 'oscillations,': [41, 218, 2691, 3163], 'versatile': [43, 220], 'signal': [45, 222, 402, 785], 'controlling': [46, 223], 'diverse': [48, 225], 'range': [49, 226, 2505, 2626], 'cellular': [51, 228, 2223], 'processes.': [52, 229], 'Here': [53, 230, 787], 'we': [54, 89, 159, 231, 266, 336, 681, 788, 1965, 2692, 2983, 2994, 3289, 3464, 3902], 'report': [55, 232], 'Na,K-ATPase': [57, 96, 104, 130, 234, 273, 281, 307, 354, 399, 496, 695, 747, 761, 780, 805, 888, 1061, 2569, 2585, 2688, 3409, 3450, 3471, 3481, 3711, 3721, 3731, 3806, 3857, 3881, 3971, 4002, 4016, 4033, 4044, 4088, 4101, 4165], 'inositol': [59, 236, 737, 815, 817, 849, 851], '1,4,5-trisphosphate': [60, 237, 639, 663, 738, 816, 818, 850, 852], '(InsP3)': [61, 238, 739], 'receptor': [62, 239, 740, 819, 853], '(InsP3R)': [63, 240, 741], 'form': [64, 241, 4114], 'cell': [66, 166, 243, 343, 594, 768, 1268, 1279, 1507, 2197, 2379, 2534, 2540, 4058, 4160], 'signaling': [67, 167, 244, 344, 595, 810, 3285, 3724, 4226], 'microdomain': [68, 168, 245, 345], 'that,': [69, 246], 'presence': [72, 249], 'generates': [75, 252], 'slow': [76, 253, 698], 'oscillations': [78, 113, 135, 143, 255, 290, 312, 320, 701, 722, 795, 2498, 2513, 2559, 2669, 2732, 2771, 2999, 3035, 3241, 3346, 3377, 3386], 'renal': [80, 257, 627, 812, 846, 1223], 'cells.': [81, 258, 2568, 2677, 2735, 3235, 3820, 3924, 4036], 'Using': [82, 259, 625, 2991], 'fluorescent': [83, 260, 653, 677, 820, 842, 854, 876, 1723], 'resonance': [84, 261, 641, 665, 821, 855, 1817], 'energy': [85, 262, 642, 666, 822, 856, 1818], 'transfer': [86, 263, 823, 857, 1819], '(FRET)': [87, 264, 1820], 'measurements,': [88, 265], 'detected': [90, 267, 2515], 'close': [92, 269], 'spatial': [93, 270, 3447], 'proximity': [94, 271], 'between': [95, 103, 272, 280, 727, 1781, 2083, 3449, 3660, 3710, 3730, 3880, 3970, 4001], 'InsP3R.': [98, 106, 275, 283], 'Ouabain': [99, 276, 524, 2727, 3236, 3697, 3821], 'significantly': [100, 277, 3699, 3822, 4079], 'enhanced': [101, 278, 844, 878, 3617, 3777], 'FRET': [102, 108, 279, 285, 1126, 1522, 1844, 1931, 2101, 3457, 3534, 3556, 3658, 3701, 3728, 3775, 3879, 3925, 3969], 'The': [107, 284, 512, 898, 931, 971, 1002, 1014, 1072, 1098, 1880, 2023, 2100, 2336, 2800, 2835, 3179, 3225, 3253, 3537, 3559, 3609, 4037, 4094], 'effect': [109, 286, 2858, 2986, 3328], 'ouabain-induced': [111, 288, 2997, 3161, 3344, 3375, 3384], 'were': [114, 152, 291, 329, 1019, 1104, 1225, 1359, 1393, 1405, 1475, 1480, 1500, 1529, 1561, 1626, 1682, 1705, 1733, 1752, 1822, 2013, 2066, 2095, 2124, 2131, 2168, 2204, 2271, 2282, 2293, 2304, 2340, 2409, 2514, 2529, 2563, 2660, 2670, 2712, 3000, 3166, 3430, 3438, 3459, 3544, 3647, 4239], 'not': [115, 292, 521, 749, 1804, 2729, 2763, 3264, 3348, 3369, 3373, 3388, 3894, 3963, 3975, 4063, 4071], 'observed': [116, 293, 2565, 2671, 3878], 'following': [117, 294, 1363, 3614], 'disruption': [118, 295], 'actin': [121, 298, 4177], 'cytoskeleton.': [122, 299], 'Partial': [123, 300], 'truncation': [124, 301, 919, 934], 'NH2': [127, 304, 937, 1063, 1131, 3528], 'terminus': [128, 305, 938, 1064, 1132, 3529, 3574], 'catalytic': [131, 308], 'α1-subunit': [132, 309, 889, 1062, 2246], 'abolished': [133, 310, 3001, 3364], 'downstream': [137, 314], 'activation': [138, 315, 704, 1639, 1770, 3048], 'NF-κB.': [140, 317], 'Ouabain-induced': [141, 318], 'occurred': [144, 321, 723], 'cells': [146, 323, 1224, 1232, 1291, 1336, 1350, 1474, 1493, 1499, 1525, 1644, 1677, 1704, 1748, 1760, 1773, 1797, 1803, 1985, 2123, 2508, 2527, 2546, 2659, 2774, 2912, 3006, 3165, 3246, 3268, 3291, 3324, 3331, 3358, 3467, 3474, 3486, 3739, 4076, 4109, 4238], 'expressing': [147, 324, 1527, 1749, 1798, 1805, 1987, 3247, 3269, 3332, 3339, 3469], 'an': [148, 170, 325, 347, 356, 395, 498, 725, 989, 3029, 3176, 4234], 'InsP3': [149, 156, 326, 333, 1178, 3158, 3174, 3177, 3180, 3189, 3193, 3249, 3271, 3279, 3301, 3334, 3391], 'sponge': [150, 327, 1179, 3250, 3280, 3335], 'hence': [153, 330], 'independent': [154, 331], 'generation.': [157, 334], 'Thus,': [158, 335, 1947], 'present': [160, 337, 4054], 'principle': [163, 340], 'where': [169, 346, 365], 'pump': [172, 349, 2937], 'serves': [173, 350], 'receptor.': [176, 353, 756], 'is': [355, 771, 798, 1949, 2571, 2902, 3044, 3068, 3974, 4005], 'integral': [357, 3908], 'membrane': [358, 2062, 2089, 3910, 3988, 3991], 'protein': [359, 843, 877, 1032, 1169, 2207, 2274, 2338], 'expressed': [360, 1288, 2755, 3441, 3921], 'all': [362, 1102, 3322, 3330, 4159], 'eukaryotic': [363], 'cells,': [364, 680, 1266, 1277, 2065, 2758, 3288, 3404], 'it': [366, 770, 1948], 'functions': [367], 'Na+': [374, 1403], 'K+': [376], 'concentrations': [377, 686, 2914, 2972], '(1.Skou': [378], 'J.C.': [379], 'Esmann': [380], 'M.': [381, 409, 430, 470, 605, 1144, 1422, 1585, 1597, 1656, 2470, 2592, 2780, 3586, 3598, 4126, 4132], 'J.': [382, 435, 479, 558, 576, 955, 1154, 1197, 1310, 2826, 3107, 3209, 3306, 3505, 4135, 4189], 'Bioenerg.': [383], 'Biomembr.': [384], '1992;': [385], '24:': [386, 1855, 1981], '249-261PubMed': [387], 'Google': [388, 427, 449, 467, 493, 567, 587, 623, 969, 1162, 1211, 1263, 1324, 1440, 1469, 1606, 1674, 1878, 1929, 2488, 2610, 2656, 2798, 2833, 2898, 2964, 3104, 3133, 3151, 3223, 3313, 3519, 3607, 3695, 4149, 4199, 4220], 'Scholar).': [389, 494, 588, 624, 970, 1163, 1212, 1325, 1470, 1675, 1879, 1930, 1983, 2611, 2657, 2799, 2834, 2899, 2965, 3152, 3224, 3314, 3520, 3608, 3696, 4221], 'studies,': [391, 1523, 3400], 'however,': [392, 3061], 'point': [393, 1174], 'additional': [396, 990], 'role': [397, 514, 766, 3156], 'transducer': [403], '(2.Aizman': [404, 600, 1417, 1651, 2465, 2587, 2775], 'O.': [405, 601, 1418, 1652, 2466, 2588, 2776], 'Uhlen': [406, 602, 1419, 1653, 2467, 2589, 2777], 'P.': [407, 456, 603, 1237, 1307, 1420, 1443, 1654, 2468, 2590, 2778, 3502, 4202], 'Lal': [408, 604, 1421, 1655, 2469, 2591, 2779], 'Brismar': [410, 606, 1149, 1248, 1423, 1454, 1657, 2471, 2593, 2781], 'H.': [411, 607, 1150, 1249, 1424, 1455, 1658, 1917, 2472, 2594, 2782, 3079, 3683, 4124, 4182], 'Aperia': [412, 608, 1151, 1252, 1308, 1425, 1458, 1659, 2473, 2595, 2783, 3503], 'A.': [413, 420, 432, 478, 609, 616, 1152, 1192, 1239, 1253, 1255, 1309, 1426, 1433, 1445, 1459, 1461, 1581, 1591, 1660, 1667, 1901, 1909, 2474, 2481, 2596, 2603, 2649, 2784, 2791, 3083, 3126, 3204, 3504, 3582, 3592, 3667, 3675, 4120, 4213], 'Proc.': [414, 610, 1427, 1661, 2475, 2597, 2643, 2785, 3120, 4207], 'Natl.': [415, 611, 1428, 1662, 2476, 2598, 2644, 2786, 3121, 4208], 'Acad.': [416, 612, 1429, 1663, 2477, 2599, 2645, 2787, 3122, 4209], 'Sci.': [417, 613, 1430, 1664, 2478, 2600, 2646, 2788, 3123, 4210], 'U.': [418, 614, 1431, 1665, 2479, 2601, 2647, 2789, 3124, 4211], 'S.': [419, 615, 1146, 1251, 1432, 1457, 1587, 1666, 1915, 2480, 2602, 2632, 2648, 2790, 3109, 3125, 3588, 3681, 4212], '2001;': [421, 617, 1434, 1668, 1854, 1867, 1980, 2482, 2604, 2792], '98:': [422, 618, 1435, 1669, 2483, 2605, 2793], '13420-13424Crossref': [423, 619, 1436, 1670, 2484, 2606, 2794], 'PubMed': [424, 446, 464, 490, 564, 620, 966, 1159, 1208, 1260, 1321, 1437, 1466, 1603, 1671, 1875, 1926, 2485, 2607, 2653, 2795, 2830, 2895, 2961, 3101, 3130, 3148, 3220, 3310, 3516, 3604, 3692, 4146, 4198, 4217], 'Scopus': [425, 447, 465, 491, 565, 621, 967, 1160, 1209, 1261, 1322, 1438, 1467, 1604, 1672, 1876, 1927, 2486, 2608, 2654, 2796, 2831, 2896, 2962, 3102, 3131, 3149, 3221, 3311, 3517, 3605, 3693, 4147, 4218], '(242)': [426, 622, 1439, 1673, 2487, 2609, 2797], 'Scholar,': [428, 450, 468, 568, 1441, 1857, 3105, 3134, 4200], '3.Haas': [429], 'Askari': [431, 477], 'Xie': [433, 473], 'Z.': [434, 474, 3085], 'Biol.': [436, 480, 956, 1198, 1311, 1866, 3210, 3506, 4136, 4190], 'Chem.': [437, 481, 957, 1199, 1312, 3211, 3507, 4137, 4191], '2000;': [438, 461, 1257, 1463], '275:': [439], '27832-27837Abstract': [440], 'Full': [441, 443, 485, 487, 961, 963, 1203, 1205, 1316, 1318, 1870, 1872, 3096, 3098, 3143, 3145, 3215, 3217, 3511, 3513, 4141, 4143, 4195], 'Text': [442, 444, 486, 488, 962, 964, 1204, 1206, 1317, 1319, 1871, 1873, 3097, 3099, 3144, 3146, 3216, 3218, 3512, 3514, 4142, 4144, 4196], 'PDF': [445, 489, 965, 1207, 1320, 1874, 3100, 3147, 3219, 3515, 4145, 4197], '(296)': [448], '4.Lichtstein': [451], 'D.': [452, 1913, 3679], 'McGowan': [453], 'M.H.': [454], 'Russell': [455], 'Carper': [457], 'D.A.': [458, 4204], 'Hypertens.': [459], 'Res.': [460], '23:': [462], 'S51-S53Crossref': [463], '(11)': [466], '5.Peng': [469], 'Huang': [471, 475], 'L.': [472, 2818, 2877, 2943], 'W.H.': [476], '1996;': [482, 958], '271:': [483, 959], '10372-10378Abstract': [484], '(168)': [492, 3132], 'Importantly,': [495], 'has': [497], 'ligand,': [500], 'steroid': [503], 'hormone': [504], 'dose-dependently': [506, 2572], 'inhibits': [507], 'activity': [509, 696, 2570, 2586], 'Na,K-ATPase.': [511], 'biological': [513], 'ouabain': [516, 599, 688, 797, 1687, 2490, 2520, 2549, 2579, 2664, 3743, 3813, 4078], 'is,': [517], 'despite': [518], 'extensive': [519], 'research,': [520], 'well': [522, 3295], 'understood.': [523], 'belongs': [525], 'family': [528], 'cardiac': [530, 550], 'glycosides,': [531], 'which': [532, 779, 2687, 3522, 3552], 'been': [534, 2863], 'used': [535, 633, 657, 1360, 1891, 2373, 2693, 3465], 'centuries': [537], 'treatment': [540, 3698, 3744, 3814], 'heart': [542], 'disease.': [543], 'Recently,': [544], 'several': [545], 'investigators': [546], 'noted': [548], 'glycosides': [551], 'may': [552, 2216, 2921], 'act': [553, 782], 'anticancer': [555], 'agents': [556], '(6.Haux': [557], 'Med.': [559], 'Hypotheses.': [560], '1999;': [561, 1923, 3689], '53:': [562], '543-548Crossref': [563], '(140)': [566], '7.Repke': [569], 'K.R.': [570], 'Schon': [571], 'R.': [572, 574, 954, 1293, 3488], 'Megges': [573], 'Weiland': [575], 'Nissen': [577], 'E.': [578, 580, 1305, 3500], 'Matthes': [579], 'Anti-Cancer': [581], 'Drug': [582], 'Des.': [583], '1995;': [584, 3307, 4138], '10:': [585], '177-187PubMed': [586], 'described': [591, 1235, 1415, 1649, 1702, 2383], 'new': [593], 'pathway': [596], 'triggered': [597, 3036, 3237], 'by': [598, 778, 796, 893, 903, 1021, 1067, 1106, 1645, 1754, 1777, 1938, 1972, 2035, 2219, 2346, 2574, 2686, 2714, 2906, 3037, 3071, 3562, 3753, 3778, 3785, 4175], 'rat': [626, 887, 1230, 2584], 'proximal': [628, 636, 660, 813, 847], 'tubule': [629, 814, 848], '(RPT)': [630], '1The': [631], 'abbreviations': [632, 656], 'are:': [634, 658], 'RPTrenal': [635, 659], 'tubuleInsP3inositol': [637, 661], '1,4,5-trisphosphateInsP3Rinositol': [638, 662], 'receptorFRETfluorescent': [640, 664], 'transferPLCphospholipase': [643, 667], 'CERendoplasmic': [644, 668], 'reticulumSERCAsarco-endoplasmic': [645, 669], 'reticulum': [646, 670, 827, 829, 861, 863, 2708, 2719], 'ATPaseCPAcyclopiazonic': [648, 672], 'acid2-APB2-aminoethoxydiphenyl': [649, 673], 'borateCytDcytochalasin': [650, 674], 'DAQP4aquaporin-4GSTglutathione': [651, 675], 'S-transferaseGFPgreen': [652, 676], 'proteinEGFPenhanced': [654, 678], 'GFP.1The': [655], 'GFP.': [679, 845, 879], 'showed': [682, 2550], 'exposure': [684, 2521], 'cause': [690, 2923], 'only': [691, 3340, 4046], 'partial': [692, 3406], 'inhibition': [693, 2582, 2838, 2933], 'induces': [697], 'subsequent': [703, 1118, 2679, 3433], 'transcription': [707], 'factors': [708], 'NF-κB': [709, 1638, 1708, 1757, 1769, 1784], 'cAMP-response': [711], 'element-binding': [712], 'protein.': [713], 'Our': [714], 'results': [715, 3635], 'from': [716, 1215, 1271, 1282, 1394, 1494, 1510, 2739], 'study': [718, 1894], 'indicated': [719, 2445, 3752, 3845], 'interplay': [726], 'different': [728], 'transporters': [730], 'release': [734, 2738, 2842, 3024, 3198], 'via': [735, 2746, 2749, 3027], 'was': [742, 891, 901, 927, 939, 975, 1005, 1045, 1065, 1075, 1136, 1180, 1214, 1286, 1331, 1345, 1640, 1761, 1774, 1895, 2026, 2054, 2233, 2353, 2372, 2389, 2450, 2454, 2804, 2843, 3259, 3326, 3351, 3523, 3776, 3884, 3920, 3927, 3956, 4102], 'involved': [743], 'this': [745, 1893, 2992, 3397, 3462, 3889, 3959], 'event.': [746], 'does': [748], 'possess': [750], 'characteristics': [752], 'G-protein-coupled': [755], 'Given': [757], 'generality': [759], 'expression': [762], 'significant': [765], 'homeostasis,': [769], 'important': [772], 'identify': [774], 'molecular': [776, 3960], 'mechanisms': [777], 'transducer.': [786], 'show': [789], 'generation': [792], 'dependent': [799, 3046], 'on': [800, 941, 996, 1337, 1351, 1824, 2063, 2164, 2859, 3047, 3402, 3453, 3986, 4233], 'physical': [802, 3999], 'association': [803, 4000], 'InsP3R': [807, 1164, 1567, 3066, 3395, 3411, 3452, 3713, 3723, 4018, 4112, 4167], 'microdomain.': [811, 4024], 'phospholipase': [824, 858, 3050], 'C': [825, 859, 3051], 'endoplasmic': [826, 860, 2707], 'sarco-endoplasmic': [828, 862, 2718], 'ATPase': [831, 865, 2721], 'cyclopiazonic': [832, 866, 1367], 'acid': [833, 867, 1368], '2-aminoethoxydiphenyl': [834, 868, 1381], 'borate': [835, 869, 1382], 'cytochalasin': [836, 870, 1372], 'D': [837, 871, 1373], 'aquaporin-4': [838, 872, 1134], 'glutathione': [839, 873, 1035], 'S-transferase': [840, 874, 1036], 'green': [841, 875], 'Expression': [880], 'Plasmids—A': [881], 'cDNA': [882, 1053], 'fragment': [883, 1054], 'encoding': [884, 1055, 1177, 3171], 'wild': [885, 3483], 'type': [886, 1165, 1568, 1572, 3484], '(NKAα1)': [890], 'amplified': [892, 1066], 'AmpliTaq': [894, 1068], 'Gold': [895, 1069], '(Applied': [896, 1070], 'Biosystems).': [897, 1071], 'PCR': [899, 1015, 1073], 'product': [900, 1016, 1074], 'digested': [902], 'ApaI/XbaI': [904], 'restriction': [905, 1023], 'enzymes': [906, 1024], 'cloned': [908, 1076, 1181], 'into': [909, 1089, 1182, 1334, 1348], 'pEGFP-C2': [910], '(Clontech)': [911], 'obtain': [913, 1096, 1141, 2194], 'pGFP-NKAα1.': [914], 'A': [915, 1030, 1839], 'mutant': [916], 'NKAα1': [917, 983, 1043], 'with': [918, 988, 1033, 1138, 1173, 1531, 1542, 1563, 1628, 1680, 1684, 1707, 1720, 1991, 2015, 2038, 2206, 2241, 2273, 2287, 2307, 2364, 2405, 2462, 2499, 2548, 2716, 2932, 3008, 3073, 3168, 3292, 3359, 3410, 3546, 3740, 3765, 3829, 3856, 4032, 4043, 4077, 4086, 4100, 4156, 4241], 'first': [922], '32': [923], 'amino': [924, 1040, 1057, 1171], 'acids': [925, 1041, 1058], '(NKAα1.M32)': [926], 'generated': [928], 'using': [929, 1047, 1080, 1091, 1121, 1341, 1355, 1407, 1694, 1735, 1808, 1834, 2074, 2177, 2299, 2321, 2331, 3906, 3929], 'PCR.': [930], 'region': [932, 2034, 2113], 'decided': [940], 'basis': [943], 'structure/function': [945], 'analysis': [946, 1120, 3800, 3926], 'reported': [947, 2844], 'elsewhere': [948, 1849], '(8.Daly': [949], 'S.E.': [950, 2437, 3833], 'Lane': [951], 'L.K.': [952], 'Blostein': [953], '23683-23689Abstract': [960], '(55)': [968], 'sense': [972], 'primer': [973, 1004], 'sequence': [974], '5′-AAAGGGCCCATGGAAGTGTCTATGGACGAC-3′,': [976], 'corresponding': [977, 1007], 'nucleotide': [979, 1009, 1099], 'positions': [980, 1010], '349–366': [981], '(GenBank™': [984], 'accession': [985], 'number': [986], 'NM_012504)': [987], 'ApaI': [991], 'site': [992], 'ATG': [994], 'codon': [995], '5′-end': [998], 'primer.': [1001], 'antisense': [1003], '5′-CTTGCCGTGGAGGAGGATAGAACT-3′,': [1006], '1792–1815': [1011], 'NKAα1.': [1013], 'pGFP-NKAα1': [1018], 'hydrolyzed': [1020], 'ApaI/AflII': [1022], 'ligated': [1026], 'cloning': [1028, 1084], 'pGFP-NKAα1.M32.': [1029], 'fusion': [1031], 'NH2-terminal': [1034], '(GST)': [1037], '95': [1039, 1056], '(GST-NKAα1.N95)': [1044], 'constructed': [1046], 'Gateway': [1048, 1092], 'Technology': [1049], '(Invitrogen).': [1050], 'Briefly,': [1051], 'pENTR/D-TOPO': [1078], 'vector': [1079, 1185], 'pENTR': [1081], 'Directional': [1082], 'TOPO': [1083], 'kit': [1085], '(Invitrogen)': [1086, 1094], 'subcloned': [1088], 'pDEST-15': [1090], 'System': [1093], 'pGST-NKAα1.N95.': [1097], 'sequences': [1100], 'constructs': [1103], 'confirmed': [1105], 'automated': [1107], 'sequencing': [1108], '(KISEQ,': [1109], 'Core': [1110], 'Facilities': [1111], 'Karolinska': [1113], 'Institutet,': [1114], 'Stockholm,': [1115], 'Sweden)': [1116], 'bioinformatics': [1119], 'Lasergene': [1122], 'software': [1123], '(DNASTAR).': [1124], 'For': [1125, 2678, 3914], 'control': [1127, 3904, 3917], 'experiments,': [1128, 2443, 3918], 'cytosolic': [1130, 2561, 2869, 2929, 3527], '(AQP4)': [1135], 'tagged': [1137], 'GFP': [1139, 1755, 1888, 2052, 2084, 3229, 3341, 3661], 'pGFP-AQP4': [1142, 1344], '(9.Zelenina': [1143], 'Zelenin': [1145], 'Bondar': [1147], 'A.A.': [1148], 'Am.': [1153], 'Physiol.': [1155], '2002;': [1156, 1200, 2827, 3127, 3140, 3212], '283:': [1157, 1924, 3690], 'F309-F318Crossref': [1158], '(173)': [1161], '1': [1166, 1558, 1716, 2150, 2210, 2236, 2319], 'binding': [1168], '(226–604': [1170], 'acids)': [1172], 'mutation': [1175], '(R441Q)': [1176], 'pEF-BOS-MCS': [1184], '(pEF-GSTm49-IRES-GFP)': [1186], '(10.Uchiyama': [1187, 3199], 'T.': [1188, 1194, 1241, 1243, 1297, 1447, 1449, 1579, 1583, 1899, 3200, 3206, 3492, 3580, 3584, 3665, 4118, 4122, 4128, 4130], 'Yoshikawa': [1189, 3201], 'F.': [1190, 1245, 1451, 1905, 2638, 3117, 3202, 3671], 'Hishida': [1191, 3203], 'Furuichi': [1193, 3205, 4127], 'Mikoshiba': [1195, 1594, 3207, 3595, 4133], 'K.': [1196, 1589, 1595, 3115, 3208, 3590, 3596, 4134], '277:': [1201, 3213], '8106-8113Abstract': [1202, 3214], '(80)': [1210, 3222], 'pEGFP-actin': [1213, 1330], 'Clontech.': [1216], 'Cell': [1217, 1865, 2166, 2890, 2956], 'Culture': [1218], 'Transfections—Three': [1220], 'types': [1221, 3412, 4161], 'used:': [1226], 'primary': [1227, 3538], 'cultures': [1228], 'RPT': [1231, 1335, 1643, 1676, 2378, 2507, 2757, 3164, 3287, 3357, 3862, 4106, 4237], 'prepared': [1233], '(11.Uhlen': [1236], 'Laestadius': [1238, 1444], 'Jahnukainen': [1240, 1446], 'Soderblom': [1242, 1448], 'Backhed': [1244, 1450], 'Celsi': [1246, 1452], 'G.': [1247, 1453, 1903, 3669], 'Normark': [1250, 1456], 'Richter-Dahlfors': [1254, 1460], 'Nature.': [1256, 1462], '405:': [1258, 1464], '694-697Crossref': [1259, 1465], '(200)': [1262, 1468], 'Scholar),': [1264, 2489, 4150], 'COS-7': [1265, 1290, 1349, 1524, 1984, 2545, 3403, 3466, 3485, 3738, 3819, 3923, 4035, 4075], 'line': [1269, 1280], 'derived': [1270, 1281], 'fetal': [1272], 'monkey': [1273], 'kidney,': [1274], 'LLC-PK1': [1276, 3864, 4108], 'pig': [1283], 'kidney.': [1284], 'GFP-NKAα1': [1285, 1528, 1988, 3610, 3643, 3735], 'stably': [1287, 1526, 1986, 3468], '(12.Belusa': [1292, 3487], 'Wang': [1294, 3084, 3489], 'Z.M.': [1295, 3490], 'Matsubara': [1296, 3491], 'Sahlgren': [1298, 3493], 'B.': [1299, 3494], 'Dulubova': [1300, 3495], 'I.': [1301, 3091, 3496], 'Nairn': [1302, 3497], 'A.C.': [1303, 3498], 'Ruoslahti': [1304, 3499], 'Greengard': [1306, 3501], '1997;': [1313, 3508], '272:': [1314, 3509], '20179-20184Abstract': [1315, 3510], '(54)': [1323, 3518], 'pGFP-NKAα1,': [1326], 'pGFP-NKAα1.M32,': [1327], 'pEF-GSTm49-IRES-GFP,': [1328], 'or': [1329, 1571, 1800, 2260, 2748, 3542], 'transiently': [1332, 1346, 1678], 'transfected': [1333, 1347, 1679, 3167, 3234], 'culture': [1338, 1352], 'day': [1339, 1353], '2': [1340, 1354, 1569, 1945, 2172, 2176], 'CLONfectin': [1342, 1356], '(Clontech).': [1343, 1357], 'Reagents—Reagents': [1358], 'at': [1361, 1536, 1609, 2059, 2174, 2186, 2190, 2238, 2278, 2402, 2456, 2535], 'concentrations:': [1364], '20': [1365, 2975], 'μm': [1366, 1371, 1377, 1380, 1385, 1389, 1686, 2578, 2695, 2908, 2920, 2989, 3812], '(CPA),': [1369], '5': [1370, 1379, 1388, 2988], '(CytD),': [1374], '100': [1375, 2919], 'pm-250': [1376], '(2-APB),': [1383], '0.5': [1384, 1940], 'bradykinin,': [1386, 3293], 'U73122.': [1390], 'All': [1391], 'reagents': [1392], 'Sigma.': [1395], 'Intracellular': [1396], 'Calcium': [1397], 'Sodium': [1399], 'Measurements—Intracellular': [1400], 'measurements': [1404, 1821, 3458, 3729], 'performed': [1406, 1823, 3401, 3928], 'Fura-2/AM': [1408], 'SBFI/AM': [1410], '(Molecular': [1411], 'Probes),': [1412], 'respectively,': [1413], '11.Uhlen': [1442], 'After': [1471, 2225], 'baseline': [1472], 'recording,': [1473], 'treated,': [1476], 'ratio': [1478, 1780, 2397, 3950], 'images': [1479, 1746, 3736], 'recorded': [1481], 'every': [1482], '30': [1483, 1689, 1730, 2162, 3816], 's': [1484, 2173], '45–90': [1486], 'min.': [1487, 1731], 'In': [1488, 2118, 2460, 3461, 3852], 'each': [1489, 2127], 'dish,': [1490], '20–30': [1491], 'individual': [1492, 1772, 2064], 'single': [1496, 1506, 3317], 'cluster': [1497], 'analyzed.': [1501], 'Results': [1502], 'presented': [1503, 2103, 2433], 'are': [1504, 1936, 1955, 2104, 2432, 2753, 3568, 3844, 4019, 4173], 'representative': [1505, 3794], 'traces': [1508], 'obtained': [1509], 'minimum': [1512, 2440], '12': [1514, 3651], 'experiments.': [1515], 'Immunocytochemistry': [1516], 'Confocal': [1518], 'Microscopy—For': [1519], 'co-immunolocalization': [1520], 'fixed': [1530, 1693], 'acetone': [1532], '3': [1534, 1573, 3416], 'min': [1535, 1690, 2163, 2518, 3817], 'room': [1537], 'temperature': [1538], 'then': [1540, 1692, 1719, 2027, 2317], 'incubated': [1541, 1706, 2234, 2272, 2286, 2305, 2400], 'phosphate-buffered': [1543], 'saline': [1544], 'containing': [1545], '5%': [1546], '(v/v)': [1547, 2398], 'normal': [1548], 'goat': [1549, 1613, 1994], 'serum': [1550, 1555], '3%': [1552, 1695], '(w/v)': [1553], 'bovine': [1554], 'albumin': [1556], 'h.': [1559], 'InsP3Rs': [1560, 2747, 2752, 2812, 3043, 3578], 'probed': [1562, 3545], 'monoclonal': [1564, 2005, 2244, 2253, 2263, 2310], 'mouse': [1565, 2004, 2243, 2252, 2262, 2309], 'anti-rat': [1566], '(KM1083)': [1570, 2009], '(KM1082)': [1574, 2012], 'antibodies': [1575, 3539, 3567], '(1': [1576, 2313], 'μg/ml)': [1577], '(13.Sugiyama': [1578, 3579], 'Furuya': [1580, 3581], 'Monkawa': [1582, 3583], 'Yamamoto-Hino': [1584, 3585, 4125], 'Satoh': [1586, 3587], 'Ohmori': [1588, 3589], 'Miyawaki': [1590, 3591, 4119], 'Hanai': [1592, 3593], 'N.': [1593, 3113, 3594, 4184], 'Hasegawa': [1596, 3597, 4131], 'FEBS': [1598, 3599], 'Lett.': [1599, 3600], '1994;': [1600, 3601, 4214], '354:': [1601, 3602], '149-154Crossref': [1602, 3603], '(82)': [1605, 3606], 'Scholar)': [1607], 'overnight': [1608, 2277, 2306, 2401], '4': [1610, 2191, 2239, 2279, 2403], '°C.': [1611, 2280], 'Cy3-conjugated': [1612, 3548], 'anti-mouse': [1614, 1995], 'IgG': [1615, 1996, 3549, 4061], 'antibody': [1616, 1620, 1710, 1725, 1998, 2006, 2247, 2255, 2264, 2266, 2312, 2326, 3937, 3942], 'served': [1617, 3532, 3553], 'secondary': [1619, 1724, 1993, 1997, 2325, 3550, 3936], '(1:1000,': [1621], 'Jackson': [1622], 'ImmunoResearch': [1623, 2000], 'Laboratories).': [1624], 'Cells': [1625, 3338], 'scanned': [1627, 1734, 2341], 'Leica': [1630, 1737, 1826], 'TCS': [1631, 1738, 1827], 'SP': [1632, 1739, 1828], 'inverted': [1633, 1740, 1829], 'confocal': [1634, 1741, 1830], 'scanning': [1635, 1742, 1831], 'laser': [1636, 1743, 1832], 'microscope.': [1637], 'measured': [1641, 2125], 'immunocytochemical': [1646], 'staining': [1647], 'pGFP-NKAα1.M32': [1681], 'treated': [1683, 2547, 3007, 3290], '250': [1685, 2577, 2613, 2694, 3811], 'paraformaldehyde': [1696], '(10': [1697], 'min).': [1698], 'Following': [1699], 'blocking': [1700], 'above,': [1703], 'p65': [1709], '(1:200,': [1711], 'Santa': [1712, 2257], 'Cruz': [1713, 2258], 'Biotechnology)': [1714], 'h': [1717, 2211, 2237, 2320], 'Alexa': [1721], '546': [1722], '(1:500,': [1726], 'Molecular': [1727, 3841], 'Probes)': [1728], 'Slides': [1732], 'microscope,': [1744], 'construct': [1751, 1807, 3170, 3226], 'identified': [1753], 'signal;': [1756], 'immunostaining': [1758], 'captured': [1762], 'same': [1765, 3478, 3934], 'field': [1766], 'view.': [1768], 'semiquantitatively': [1775], 'estimated': [1776, 2620], 'measuring': [1778], 'mean': [1783, 3768, 3831], 'immunosignal': [1785], 'given': [1788], 'comparable': [1789], 'area': [1790, 2071, 3751], 'nucleus': [1793], 'cytoplasm': [1795], 'GFP-NKAα1.M32': [1799], 'those': [1801], 'adjacent': [1802], 'ImageJ': [1809, 2075], '(Wayne': [1810, 2076], 'Rasband,': [1811, 2077], 'National': [1812, 2078], 'Institutes': [1813, 2079], 'Health).': [1815, 2081], 'FRET—Fluorescent': [1816], 'microscope': [1833], '×40/1.4': [1836], 'NA': [1837], 'objective.': [1838], 'detailed': [1840], 'description': [1841], 'technique': [1845], 'be': [1847, 2217, 2622, 2846], 'found': [1848, 2995, 3353, 3957], '(14.Kenworthy': [1850, 1976], 'A.K.': [1851, 1977], 'Methods': [1852, 1978], '(Orlando).': [1853, 1979], '289-296Google': [1856, 1982], '15.Wouters': [1858], 'F.S.': [1859], 'Verveer': [1860], 'P.J.': [1861, 1921, 3687], 'Bastiaens': [1862, 1918, 3684], 'P.I.': [1863, 1919, 3685], 'Trends': [1864], '11:': [1868], '203-211Abstract': [1869], '(383)': [1877], 'Förster': [1881], 'constant,': [1882], 'R0,': [1883], 'donor-acceptor': [1886], 'pair,': [1887], 'Cy3,': [1890, 2025], '6': [1896], 'nm': [1897, 2019, 2042], '(16.Ng': [1898, 3664], 'Squire': [1900, 3666], 'Hansra': [1902, 3668], 'Bornancin': [1904, 3670], 'Prevostel': [1906, 3672], 'C.': [1907, 3673], 'Hanby': [1908, 3674], 'Harris': [1910, 2635, 3676], 'W.': [1911, 3677], 'Barnes': [1912, 3678], 'Schmidt': [1914, 3680], 'Mellor': [1916, 3682], 'Parker': [1920, 3686], 'Science.': [1922, 3688], '2085-2089Crossref': [1925, 3691], '(267)': [1928, 3694], 'occurs': [1932, 2744], 'when': [1933], 'fluorophores': [1935], 'separated': [1937, 3648], 'distances': [1939], 'R0': [1941], '<': [1942, 1944, 2458, 3773, 3839], 'r': [1943], 'R0.': [1946], 'possible': [1950], 'distinguish': [1952], 'proteins': [1953, 3075, 3892, 4171], 'spatially': [1956], 'co-localized': [1957], 'within': [1958], '12-nm': [1960], 'radius.': [1961], 'To': [1962, 2697, 3153, 3273, 3444, 3874, 4222], 'determine': [1963], 'FRET,': [1964], 'quantified': [1966], 'quenching': [1968, 3282], 'donor': [1970, 3535, 3639, 3948], 'fluorescence': [1971, 3611], 'performing': [1973], 'acceptor': [1974, 3557, 3615, 3641, 3748, 3954], 'photobleaching': [1975, 3749, 3955], 'stained': [1990], 'Cy3-labeled': [1992, 3935], '(Jackson': [1999], 'Laboratories)': [2001], 'detect': [2003, 3939], 'InsP3R2': [2008, 3423, 3541, 3564, 3622, 3859, 4154], 'InsP3R3': [2011, 3427, 3543, 3566, 3628, 3803, 3827, 3854, 3883, 3941, 3973, 4004, 4030, 4040, 4053, 4069, 4084, 4097, 4157], 'excited': [2014], '488': [2016], '543': [2018, 2039], 'collected': [2021], 'separately.': [2022], 'acceptor,': [2024], 'irreversibly': [2028], 'photobleached': [2029, 2070], 'selected': [2032, 2112], 'adequate': [2033], 'continuous': [2036], 'excitation': [2037], '633': [2041], 'lasers': [2043], '30–90': [2045], 's.': [2046], 'Thereafter,': [2047], 'residual': [2049], 'Cy3': [2050, 3663], 'image': [2053, 3871], 'obtained,': [2055], 'identical': [2057], 'regions,': [2058], 'plasma': [2061, 2088, 3909, 3987], 'outlined': [2067], 'processed': [2073], 'Ratios': [2082], 'intensities': [2085, 3760], 'region,': [2090], 'after': [2091, 2519, 3747, 3761, 3810, 3953], 'before': [2093, 3745, 3766, 3808, 3951], 'photobleaching,': [2094, 3616], 'calculated': [2096], 'quantify': [2098], 'FRET.': [2099], 'values': [2102], 'corrected': [2105], 'erroneous': [2107], 'intensity': [2108, 3612], 'changes': [2109, 3757], 'outside': [2114], 'bleached': [2116], 'area.': [2117], 'typical': [2120], 'experiment,': [2121], '10–15': [2122], 'sample.': [2128], 'Immunoprecipitation': [2129], 'Studies—Cells': [2130], 'solubilized': [2132], 'lysis': [2134], 'buffer': [2135, 2416], '(50': [2136], 'mm': [2137, 2142, 2151], 'Tris/HCL': [2138], '(pH': [2139], '7.4),': [2140], '150': [2141], 'NaCl,': [2143], '0.25%': [2144], 'deoxycholate,': [2146], '1%': [2147], 'Triton': [2148], 'X-100,': [2149], 'phenylmethylsulfonyl': [2152], 'fluoride,': [2153], 'protease': [2154], 'inhibitors': [2155], '(Roche': [2156], 'Applied': [2157], 'Science))': [2158], 'left': [2160, 3848], 'ice.': [2165], 'lysates': [2167], 'sonicated': [2169], '(3': [2170], '×': [2171, 2188], 'setting': [2175], 'Branson': [2179, 2182], 'Sonifier': [2180], '250,': [2181], 'Ultrasonics)': [2183], 'centrifuged': [2185], '9,000': [2187], 'g': [2189], '°C': [2192, 2240, 2404], 'crude': [2196], 'extract.': [2198], '500': [2199], 'μg': [2200], 'supernatant': [2202, 2232], 'protein/reaction': [2203], 'precleared': [2205], 'G-Sepharose': [2208, 2275], 'reduce': [2213], 'background': [2214], 'caused': [2218], 'non-specific': [2220, 3899, 3980], 'adsorption': [2221], 'debris.': [2224], 'low': [2227, 2971, 3238], 'speed': [2228], 'centrifugation,': [2229], 'resultant': [2231, 2337], 'anti-Na,K-ATPase': [2245], '(1:250;': [2248], 'Upstate': [2249], 'Biotechnology),': [2250, 2259], 'anti-InsP3R2': [2254], '(1:50;': [2256, 2267], 'anti-InsP3R3': [2265, 2311], 'BD': [2268], 'Biosciences).': [2269, 2335, 2369], 'Immunocomplexes': [2270], 'beads': [2276, 2367, 2393], 'Beads': [2281, 2408], 'pelleted,': [2283], 'washed,': [2284], '2×': [2288, 2414], 'Laemmli': [2289, 2415], 'buffer,': [2290], 'supernatants': [2292], 'subjected': [2294], 'SDS': [2296, 2419], 'gel': [2297, 2420], 'electrophoresis': [2298, 2421], '6%': [2300], 'acrylamide': [2301], 'gels.': [2302], 'Membranes': [2303], 'μg/ml;': [2314], 'KM1082)': [2315], 'horseradish': [2323], 'peroxidase-conjugated': [2324], '(1:5000)': [2327], 'prior': [2328, 2417], 'detection': [2330, 3659], 'ECL': [2332], 'plus': [2333], '(Amersham': [2334, 2368], 'bands': [2339], 'digitally': [2342], 'densitometrically': [2344], 'analyzed': [2345], 'Bio-Rad': [2347], 'QuantitativeOne': [2348], 'software.': [2349], 'GST': [2350, 2371], 'Pull-down': [2351], 'Assay—GST-NKAα1.N95': [2352], 'produced': [2354], 'BL21': [2357], 'strain': [2358], 'Escherichia': [2360], 'coli': [2361], 'purified': [2363], 'glutathione-Sepharose': [2365], '4B': [2366], 'Non-recombinant': [2370], 'control.': [2376], 'Detergent-extracted': [2377], 'lysate': [2380], '(prepared': [2381], 'above': [2384], 'co-immunoprecipitation': [2387, 3781], 'protocol)': [2388], 'added': [2390, 4009], '5:1': [2396], 'gentle': [2406], 'rotation.': [2407], 'washed': [2410], 'resuspended': [2412], '(6%': [2422], 'gel)': [2423], 'immunoblotting': [2425], 'InsP3R3.': [2427, 3733, 3790], 'Data': [2428], 'Presentation': [2429], 'Analysis—Data': [2431], 'means': [2435], '±': [2436, 3619, 3625, 3704, 3708, 3769, 3832], '10': [2442], 'unless': [2444], 'otherwise.': [2446], "Student's": [2447], 't': [2448], 'test': [2449], 'used,': [2451], 'significance': [2453], 'accepted': [2455], 'p': [2457, 3772, 3838], '0.05.': [2459, 3774, 3840], 'accordance': [2461], 'previous': [2463], 'observations': [2464], '(250': [2491], 'μm)': [2492, 2976, 3011], 'induced': [2493, 3316], 'highly': [2494], 'regular': [2495, 3343], 'periodicity': [2501], 'minute': [2504], '(Fig.': [2509, 2556, 2672, 2725, 3012, 3251, 3336, 3378, 3424, 3428, 3629, 3714, 4089, 4110, 4162], '1a).': [2510], 'Typical': [2511], 'about': [2516], '5–15': [2517], 'approximately': [2523, 3476], 'one-third': [2524, 3243], 'generally': [2530, 2903], 'initiated': [2531], 'one': [2533], 'periphery': [2537], 'cluster.': [2541], 'Quantitatively': [2542], 'qualitatively,': [2544], 'similar': [2552], 'oscillatory': [2554, 2704, 3257], 'response': [2555, 3258], '1b).': [2557], 'Spontaneous': [2558], 'never': [2564], 'untreated': [2567], 'inhibited': [2573, 2905], 'causes': [2580], '∼50%': [2581], 'Ouabain,': [2612], 'μm,': [2614], 'exceeds': [2615], 'circulating': [2616], 'levels': [2617, 3392], 'rat,': [2619], 'pm-nm': [2625], '(17.Hamlyn': [2627], 'J.M.': [2628], 'Blaustein': [2629], 'M.P.': [2630], 'Bova': [2631], 'DuCharme': [2633], 'D.W.': [2634, 2636], 'Mandel': [2637], 'Mathews': [2639], 'W.R.': [2640], 'Ludens': [2641], 'J.H.': [2642], '1991;': [2650], '88:': [2651], '6259-6263Crossref': [2652], '(704)': [2655], 'When': [2658], 'exposed': [2661], 'physiological': [2663], 'doses': [2665], '(100': [2666], 'pm),': [2667], '1c)': [2673], '∼1%': [2675], 'experiments': [2680, 3434, 3905], 'designed': [2681, 3903], 'explore': [2683], 'mechanism': [2685], 'triggers': [2689], 'ouabain.': [2696, 3779], 'elucidate': [2698], 'source': [2700], 'response,': [2705], '(ER)': [2709], 'stores': [2711, 2743], 'depleted': [2713], 'preincubation': [2715, 3355], '(SERCA)': [2722], 'inhibitor,': [2723, 3362], 'CPA': [2724, 3019], '1d).': [2726], 'did': [2728, 3372, 4062], 'induce': [2730], 'CPA-pretreated': [2734], 'Regulated': [2736], 'ER': [2741, 3990], 'mainly': [2745], 'ryanodine': [2750, 2760], 'receptors.': [2751], 'abundantly': [2754, 3440], 'whereas': [2759], 'receptors': [2761], 'do': [2762, 3387], 'any': [2765], 'functional': [2766], 'importance': [2767], 'ouabain-triggered': [2769], 'these': [2773, 3436, 3915], 'membrane-permeable': [2801], 'substance,': [2802], '2-APB,': [2803], 'initially': [2805], 'introduced': [2806], 'specific': [2809], 'inhibitor': [2810], '(18.Bootman': [2813], 'M.D.': [2814, 2883, 2949], 'Collins': [2815, 2874, 2940], 'T.J.': [2816, 2875, 2941], 'Mackenzie': [2817, 2876, 2942], 'Roderick': [2819, 2888, 2954], 'H.L.': [2820, 2889, 2955], 'Berridge': [2821, 2884, 2950], 'M.J.': [2822, 2885, 2951], 'Peppiatt': [2823], 'C.M.': [2824, 2873, 2939], 'FASEB': [2825, 3305], '16:': [2828], '1145-1150Crossref': [2829], '(597)': [2832], 'IC50': [2836], 'InsP3R-evoked': [2840], '1–20': [2847], 'μm.': [2848], 'Since': [2849, 2966], 'then,': [2850], '2-APB': [2851, 2916, 2978, 3009, 3021], 'has,': [2852], 'inhibitory': [2857, 3016], 'InsP3-induced': [2860, 3196], 'release,': [2862], 'shown': [2864, 4026], 'block': [2866], 'store-operated': [2867], 'calcium-mediated': [2868], 'influx': [2871], '(19.Peppiatt': [2872, 2938], 'Conway': [2878, 2944], 'S.J.': [2879, 2945], 'Holmes': [2880, 2946], 'A.B.': [2881, 2947], 'Bootman': [2882, 2948], 'Seo': [2886, 2952], 'J.T.': [2887, 2953], 'Calcium.': [2891, 2957], '2003;': [2892, 2958, 3093], '34:': [2893, 2959, 3141], '97-108Crossref': [2894, 2960], '(229)': [2897, 2963], 'Store-operated': [2900], 'calcium': [2901], 'fully': [2904], '50–100': [2907], '2-APB.': [2909, 2990], 'Exposure': [2910], 'higher': [2917, 3186], 'than': [2918, 3184, 3190, 3442, 3650], 'also': [2922, 3069, 3227, 4103], 'pronounced': [2925], 'increase': [2926], 'basal': [2928], 'Ca2+,': [2930], 'consistent': [2931], 'SERCA': [2936], 'available': [2967], 'data': [2968], 'suggest': [2969], '(up': [2973], 'will': [2979], 'preferentially': [2980], 'inhibit': [2981], 'InsP3Rs,': [2982], 'tested': [2984], 'concentration,': [2993], 'majority': [3004], '(5': [3010], '1e).': [3013], 'Collectively,': [3014], 'effects': [3017, 3981], 'demonstrate': [3022], 'InsP3Ris': [3028], 'essential': [3030], 'contributor': [3031], 'ouabain/Na,K-ATPase': [3039], 'complex.': [3040], 'Activation': [3041], 'critically': [3045], '(PLC),': [3052], 'phosphatidylinositol': [3053], 'lipid': [3054], 'hydrolysis,': [3055], 'liberation': [3057], 'InsP3.': [3059], 'Notably,': [3060], 'recent': [3062], 'modulated': [3070], 'interaction': [3072], 'accessory': [3074], '(20.Tang': [3076], 'T.S.': [3077], 'Tu': [3078], 'Chan': [3080], 'E.Y.': [3081], 'Maximov': [3082], 'Wellington': [3086], 'C.L.': [3087], 'Hayden': [3088], 'M.R.': [3089], 'Bezprozvanny': [3090], 'Neuron.': [3092, 3139], '39:': [3094], '227-239Abstract': [3095], '(391)': [3103], '21.Yang': [3106], 'McBride': [3108], 'Mak': [3110], 'D.O.': [3111], 'Vardi': [3112], 'Palczewski': [3114], 'Haeseleer': [3116], 'Foskett': [3118], 'J.K.': [3119], '99:': [3128], '7711-7716Crossref': [3129], '22.Johenning': [3135], 'F.W.': [3136], 'Ehrlich': [3137], 'B.E.': [3138], '173-175Abstract': [3142], '(15)': [3150], 'examine': [3154, 4223], 'hyper-affinity': [3173], 'absorbent,': [3175], 'sponge.': [3178, 3272], 'sponge,': [3181], 'having': [3182], 'more': [3183, 3439], '1000-fold': [3185], 'affinity': [3187], 'InsP3R,': [3191], 'traps': [3192], 'abrogates': [3195], 'encoded': [3228], 'facilitate': [3231], 'identification': [3232], 'frequency': [3239], '1f).': [3252], 'amplitude': [3254], 'attenuated': [3260], 'some,': [3262], 'but': [3263, 3325, 3371], 'all,': [3265], 'confirm': [3274, 3875], 'efficiency': [3276], 'InsP3-mediated': [3283], 'known': [3296], 'activator': [3297], 'PLC': [3299, 3361], 'production': [3302], '(23.Felder': [3303], 'C.C.': [3304], '9:': [3308], '619-625Crossref': [3309], '(449)': [3312], 'Bradykinin': [3315], 'transients': [3319, 3367], 'virtually': [3321], 'non-transfected': [3323], 'without': [3327, 3742], '1g).': [3337], 'exhibited': [3342], '(data': [3347, 3368, 3962, 4070], 'shown).': [3349, 3964, 4072], 'It': [3350], 'further': [3352, 4010], 'U73122,': [3363], 'bradykinin-induced': [3365], 'shown)': [3370], 'influence': [3374], '1h).': [3379], 'These': [3380, 3473, 3634], 'findings': [3381], 'require': [3389], 'increased': [3390, 3700, 3823, 4080], 'activate': [3394], 'model.': [3398], 'Immunocytochemical': [3399], 'revealed': [3405], 'co-localization': [3407], '1,': [3413], '2,': [3414], '(InsP3R1,': [3417], 'InsP3R2,': [3418], 'InsP3R3),': [3420], 'respectively.': [3421], 'Only': [3422], '2a)': [3425], '2b)': [3429], 'studied': [3431], 'since': [3435], 'isoforms': [3437, 4113], 'InsP3R1.': [3443], 'investigate': [3445], 'relationship': [3448], 'nanometer': [3455], 'scale,': [3456], 'performed.': [3460], 'protocol,': [3463], 'GFP-tagged': [3470], 'α1-subunit.': [3472], 'express': [3475], 'level': [3479], 'GFP,': [3521], 'fused': [3524], '(GFP-NKAα1).': [3536], 'against': [3540], 'antibody,': [3551], '(InsP3R-Cy3).': [3558], 'epitopes': [3560], 'recognized': [3561], 'located': [3569], 'cytoplasmic': [3572], 'COOH': [3573], 'respective': [3577], 'was,': [3613], '12.5': [3618], '0.9%': [3620], '15.5': [3624, 3703], '2.0%': [3626, 3705], '3,': [3630, 3715, 4090], 'b).': [3633], 'imply': [3636], 'complexes,': [3642], 'anti-InsP3R-anti-mouse': [3645], 'IgG-Cy3,': [3646], 'less': [3649], 'nm,': [3652], 'i.e.': [3653], 'maximal': [3655], 'distance': [3656], '(from': [3702], '25.0': [3707], '1.6%)': [3709], 'b).Fig.': [3718], '3Studies': [3719], 'microdomain.a': [3725], 'b,': [3727, 3755], 'a,': [3734], '(bleached': [3750], 'square).': [3754], 'quantitative': [3756], 'emission': [3759, 3949], 'bleaching': [3762], 'compared': [3764], 'bleaching,': [3767], 'S.E.,': [3770], '*,': [3771, 3837], 'c–e,': [3780], '(IP)': [3782], 'followed': [3784], 'Western': [3786, 3795], 'blotting': [3787], '(WB)': [3788], 'c': [3791, 4091], 'd,': [3793], 'blot': [3796], '(c)': [3797], 'densitometric': [3799], '(d)': [3801], 'content': [3804], 'immunoprecipitates': [3807], 'amount': [3825, 4038, 4067, 4082], 'associated': [3828, 4085], '(n': [3834], '=': [3835], '3),': [3836], 'mass': [3842], 'markers': [3843], 'blot.': [3851], 'e,': [3853], 'co-immunoprecipitated': [3855, 4031, 4042, 4155], 'COS-7,': [3861], 'cells.View': [3865], 'Large': [3866], 'Image': [3867], 'Figure': [3868], 'ViewerDownload': [3869], 'Hi-res': [3870], 'Download': [3872], '(PPT)': [3873], 'unique': [3886], 'property': [3887], 'pair': [3890, 3961], 'merely': [3895], 'result': [3897, 3966, 3978], 'experimental': [3900], 'artifacts,': [3901], 'another': [3907], 'protein,': [3911], 'namely': [3912], 'AQP4.': [3913], 'negative': [3916], 'GFP-AQP4': [3919, 3930], '(donor)': [3931], '(InsP3R3-Cy3,': [3943], 'acceptor).': [3944], 'No': [3945], 'change': [3946], 'This': [3965], 'indicates': [3967], 'likely': [3976], 'fixation': [3984], 'protocol': [3985], 'integrity': [3992], 'strengthens': [3994], 'conclusion': [3996], 'specific.': [4006], 'Co-immunoprecipitation': [4007], 'support': [4011], 'concept': [4014], 'linked': [4020], 'together': [4021], 'As': [4025], 'Fig.': [4028], '3c,': [4029], 'represented': [4045], 'fraction': [4048], '(<50%)': [4049], 'total': [4052], 'initial': [4057], 'lysate.': [4059], 'Non-immune': [4060], 'co-immunoprecipitate': [4064, 4099], 'detectable': [4066], 'Incubation': [4073], 'immunoprecipitated': [4087], 'd).': [4093], 'propensity': [4095], '3e).': [4111, 4163], 'heterotetrametric': [4115], 'channels': [4116], '(24.Monkawa': [4117], 'Sugiyama': [4121], 'Yoneshima': [4123], 'Saruta': [4129], '270:': [4139], '14700-14704Abstract': [4140], '(193)': [4148], 'expected,': [4153], 'Both': [4164], 'bind': [4168], 'cytoskeleton': [4170], 'anchored': [4174], 'network': [4178], '(25.Bourguignon': [4179], 'L.Y.': [4180], 'Jin': [4181], 'Iida': [4183], 'Brandt': [4185], 'N.R.': [4186], 'Zhang': [4187], 'S.H.': [4188], '1993;': [4192], '268:': [4193], '7290-7297Abstract': [4194], '26.Devarajan': [4201], 'Scaramuzzino': [4203], 'Morrow': [4205], 'J.S.': [4206], '91:': [4215], '2965-2969Crossref': [4216], '(131)': [4219], 'whether': [4224], 'Na,K-ATPase/InsP3R': [4230], 'complex': [4231], 'depends': [4232], 'intact': [4235], 'cytoskeleton,': [4236], 'pretreated': [4240], 'CytD': [4242], 'depolymerize': [4244]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2138831030', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 5}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 7}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 11}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2024-12-16T19:56:10.039623', 'created_date': '2016-06-24'}