Publication Information

{'id': 'https://openalex.org/W2138809862', 'doi': 'https://doi.org/10.1186/gb-2008-9-10-r150', 'title': 'Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas', 'display_name': 'Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas', 'publication_year': 2008, 'publication_date': '2008-10-13', 'ids': {'openalex': 'https://openalex.org/W2138809862', 'doi': 'https://doi.org/10.1186/gb-2008-9-10-r150', 'mag': '2138809862', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/18851746', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/2760877'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/gb-2008-9-10-r150', 'pdf_url': 'https://genomebiology.biomedcentral.com/counter/pdf/10.1186/gb-2008-9-10-r150', 'source': {'id': 'https://openalex.org/S81160022', 'display_name': 'Genome biology', 'issn_l': '1474-7596', 'issn': ['1474-7596', '1474-760X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://genomebiology.biomedcentral.com/counter/pdf/10.1186/gb-2008-9-10-r150', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5018385122', 'display_name': 'Frank Westermann', 'orcid': 'https://orcid.org/0000-0003-1584-3636'}, 'institutions': [{'id': 'https://openalex.org/I17937529', 'display_name': 'German Cancer Research Center', 'ror': 'https://ror.org/04cdgtt98', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I17937529']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Frank Westermann', 'raw_affiliation_strings': ['Department of Tumor Genetics, German Cancer Research Center, Heidelberg, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Department of Tumor Genetics, German Cancer Research Center, Heidelberg, Germany.', 'institution_ids': ['https://openalex.org/I17937529', 'https://openalex.org/I223822909']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054600000', 'display_name': 'Daniel Muth', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I17937529', 'display_name': 'German Cancer Research Center', 'ror': 'https://ror.org/04cdgtt98', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I17937529']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Daniel Muth', 'raw_affiliation_strings': ['Department of Tumor Genetics, German Cancer Research Center, Heidelberg, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Department of Tumor Genetics, German Cancer Research Center, Heidelberg, Germany.', 'institution_ids': ['https://openalex.org/I17937529', 'https://openalex.org/I223822909']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029575769', 'display_name': 'Axel Benner', 'orcid': 'https://orcid.org/0000-0002-7238-6956'}, 'institutions': [{'id': 'https://openalex.org/I17937529', 'display_name': 'German Cancer Research Center', 'ror': 'https://ror.org/04cdgtt98', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I17937529']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Axel Benner', 'raw_affiliation_strings': ['Department of Biostatistics, German Cancer Research Center, Heidelberg (Germany)'], 'affiliations': [{'raw_affiliation_string': 'Department of Biostatistics, German Cancer Research Center, Heidelberg (Germany)', 'institution_ids': ['https://openalex.org/I17937529', 'https://openalex.org/I223822909']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000376779', 'display_name': 'Tobias Bauer', 'orcid': 'https://orcid.org/0000-0002-4961-3639'}, 'institutions': [{'id': 'https://openalex.org/I17937529', 'display_name': 'German Cancer Research Center', 'ror': 'https://ror.org/04cdgtt98', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I17937529']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Tobias Bauer', 'raw_affiliation_strings': ['Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany;'], 'affiliations': [{'raw_affiliation_string': 'Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany;', 'institution_ids': ['https://openalex.org/I17937529', 'https://openalex.org/I223822909']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113778023', 'display_name': 'Kai-Oliver Henrich', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I17937529', 'display_name': 'German Cancer Research Center', 'ror': 'https://ror.org/04cdgtt98', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I17937529']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Kai-Oliver Henrich', 'raw_affiliation_strings': ['Department of Tumor Genetics, German Cancer Research Center, Heidelberg, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Department of Tumor Genetics, German Cancer Research Center, Heidelberg, Germany.', 'institution_ids': ['https://openalex.org/I17937529', 'https://openalex.org/I223822909']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061265036', 'display_name': 'André Oberthuer', 'orcid': 'https://orcid.org/0000-0002-6856-9872'}, 'institutions': [{'id': 'https://openalex.org/I1288882113', 'display_name': "Boston Children's Hospital", 'ror': 'https://ror.org/00dvg7y05', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1288882113']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'André Oberthuer', 'raw_affiliation_strings': ["Department of Pediatric Oncology, University Children's Hospital of Cologne, Cologne, Germany"], 'affiliations': [{'raw_affiliation_string': "Department of Pediatric Oncology, University Children's Hospital of Cologne, Cologne, Germany", 'institution_ids': ['https://openalex.org/I1288882113']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057450854', 'display_name': 'Benedikt Brors', 'orcid': 'https://orcid.org/0000-0001-5940-3101'}, 'institutions': [{'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}, {'id': 'https://openalex.org/I17937529', 'display_name': 'German Cancer Research Center', 'ror': 'https://ror.org/04cdgtt98', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I17937529']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Benedikt Brors', 'raw_affiliation_strings': ['Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany;'], 'affiliations': [{'raw_affiliation_string': 'Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany;', 'institution_ids': ['https://openalex.org/I223822909', 'https://openalex.org/I17937529']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017944645', 'display_name': 'Tim Beißbarth', 'orcid': 'https://orcid.org/0000-0001-6509-2143'}, 'institutions': [{'id': 'https://openalex.org/I17937529', 'display_name': 'German Cancer Research Center', 'ror': 'https://ror.org/04cdgtt98', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I17937529']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Tim Beissbarth', 'raw_affiliation_strings': ['Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg (Germany)'], 'affiliations': [{'raw_affiliation_string': 'Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg (Germany)', 'institution_ids': ['https://openalex.org/I17937529', 'https://openalex.org/I223822909']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086580140', 'display_name': 'Jo Vandesompele', 'orcid': 'https://orcid.org/0000-0001-6274-0184'}, 'institutions': [{'id': 'https://openalex.org/I2801227569', 'display_name': 'Ghent University Hospital', 'ror': 'https://ror.org/00xmkp704', 'country_code': 'BE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801227569']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Jo Vandesompele', 'raw_affiliation_strings': ['Center for Medical Genetics, Ghent University Hospital, Ghent, BELGIUM'], 'affiliations': [{'raw_affiliation_string': 'Center for Medical Genetics, Ghent University Hospital, Ghent, BELGIUM', 'institution_ids': ['https://openalex.org/I2801227569']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072598822', 'display_name': 'Filip Pattyn', 'orcid': 'https://orcid.org/0000-0003-0858-6651'}, 'institutions': [{'id': 'https://openalex.org/I2801227569', 'display_name': 'Ghent University Hospital', 'ror': 'https://ror.org/00xmkp704', 'country_code': 'BE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801227569']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Filip Pattyn', 'raw_affiliation_strings': ['Center for Medical Genetics, Ghent University Hospital, Ghent, BELGIUM'], 'affiliations': [{'raw_affiliation_string': 'Center for Medical Genetics, Ghent University Hospital, Ghent, BELGIUM', 'institution_ids': ['https://openalex.org/I2801227569']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072225157', 'display_name': 'Barbara Hero', 'orcid': 'https://orcid.org/0000-0003-4129-890X'}, 'institutions': [{'id': 'https://openalex.org/I1288882113', 'display_name': "Boston Children's Hospital", 'ror': 'https://ror.org/00dvg7y05', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1288882113']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Barbara Hero', 'raw_affiliation_strings': ["Department of Pediatric Oncology, University Children's Hospital of Cologne, Cologne, Germany"], 'affiliations': [{'raw_affiliation_string': "Department of Pediatric Oncology, University Children's Hospital of Cologne, Cologne, Germany", 'institution_ids': ['https://openalex.org/I1288882113']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077200146', 'display_name': 'Rainer König', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I17937529', 'display_name': 'German Cancer Research Center', 'ror': 'https://ror.org/04cdgtt98', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I17937529']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Rainer König', 'raw_affiliation_strings': ['Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany;'], 'affiliations': [{'raw_affiliation_string': 'Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany;', 'institution_ids': ['https://openalex.org/I17937529', 'https://openalex.org/I223822909']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061831442', 'display_name': 'Matthias Fischer', 'orcid': 'https://orcid.org/0000-0003-1363-1242'}, 'institutions': [{'id': 'https://openalex.org/I1288882113', 'display_name': "Boston Children's Hospital", 'ror': 'https://ror.org/00dvg7y05', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1288882113']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Matthias Fischer', 'raw_affiliation_strings': ["Department of Pediatric Oncology, University Children's Hospital of Cologne, Cologne, Germany"], 'affiliations': [{'raw_affiliation_string': "Department of Pediatric Oncology, University Children's Hospital of Cologne, Cologne, Germany", 'institution_ids': ['https://openalex.org/I1288882113']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5112792366', 'display_name': 'Manfred Schwab', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I17937529', 'display_name': 'German Cancer Research Center', 'ror': 'https://ror.org/04cdgtt98', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I17937529']}, {'id': 'https://openalex.org/I223822909', 'display_name': 'Heidelberg University', 'ror': 'https://ror.org/038t36y30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I223822909']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Manfred Schwab', 'raw_affiliation_strings': ['Department of Tumor Genetics, German Cancer Research Center, Heidelberg, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Department of Tumor Genetics, German Cancer Research Center, Heidelberg, Germany.', 'institution_ids': ['https://openalex.org/I17937529', 'https://openalex.org/I223822909']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4090, 'currency': 'EUR', 'value_usd': 5030, 'provenance': 'doaj'}, 'apc_paid': {'value': 4090, 'currency': 'EUR', 'value_usd': 5030, 'provenance': 'doaj'}, 'fwci': 11.316, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 251, 'citation_normalized_percentile': {'value': 0.944684, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '9', 'issue': '10', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12226', 'display_name': 'Neuroblastoma Research and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12226', 'display_name': 'Neuroblastoma Research and Treatments', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12286', 'display_name': 'Erythrocyte Function and Pathophysiology', 'score': 0.9509, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10631', 'display_name': 'Cancer, Hypoxia, and Metabolism', 'score': 0.9409, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/n-myc', 'display_name': 'N-Myc', 'score': 0.78736144}, {'id': 'https://openalex.org/keywords/chromatin-immunoprecipitation', 'display_name': 'Chromatin immunoprecipitation', 'score': 0.5437755}], 'concepts': [{'id': 'https://openalex.org/C2776715637', 'wikidata': 'https://www.wikidata.org/wiki/Q938205', 'display_name': 'Neuroblastoma', 'level': 3, 'score': 0.9356961}, {'id': 'https://openalex.org/C2777956278', 'wikidata': 'https://www.wikidata.org/wiki/Q14906753', 'display_name': 'N-Myc', 'level': 5, 'score': 0.78736144}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.69045496}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.68092006}, {'id': 'https://openalex.org/C134320426', 'wikidata': 'https://www.wikidata.org/wiki/Q901026', 'display_name': 'Chromatin immunoprecipitation', 'level': 5, 'score': 0.5437755}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.5389171}, {'id': 'https://openalex.org/C2781018059', 'wikidata': 'https://www.wikidata.org/wiki/Q207609', 'display_name': 'Oncogene', 'level': 4, 'score': 0.4845335}, {'id': 'https://openalex.org/C127716648', 'wikidata': 'https://www.wikidata.org/wiki/Q104053', 'display_name': 'Phenotype', 'level': 3, 'score': 0.4699217}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.40547657}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.33821523}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.25312126}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.21205556}, {'id': 'https://openalex.org/C101762097', 'wikidata': 'https://www.wikidata.org/wiki/Q224093', 'display_name': 'Promoter', 'level': 4, 'score': 0.1477131}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.09860426}, {'id': 'https://openalex.org/C2779102060', 'wikidata': 'https://www.wikidata.org/wiki/Q1124606', 'display_name': 'Ganglioneuroma', 'level': 4, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D009447', 'descriptor_name': 'Neuroblastoma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D009447', 'descriptor_name': 'Neuroblastoma', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015513', 'descriptor_name': 'Oncogene Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016271', 'descriptor_name': 'Proto-Oncogene Proteins c-myc', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014158', 'descriptor_name': 'Transcription, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D018450', 'descriptor_name': 'Disease Progression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016259', 'descriptor_name': 'Genes, myc', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071447', 'descriptor_name': 'N-Myc Proto-Oncogene Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009447', 'descriptor_name': 'Neuroblastoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D009687', 'descriptor_name': 'Nuclear Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015513', 'descriptor_name': 'Oncogene Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015513', 'descriptor_name': 'Oncogene Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016271', 'descriptor_name': 'Proto-Oncogene Proteins c-myc', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016271', 'descriptor_name': 'Proto-Oncogene Proteins c-myc', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016019', 'descriptor_name': 'Survival Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/gb-2008-9-10-r150', 'pdf_url': 'https://genomebiology.biomedcentral.com/counter/pdf/10.1186/gb-2008-9-10-r150', 'source': {'id': 'https://openalex.org/S81160022', 'display_name': 'Genome biology', 'issn_l': '1474-7596', 'issn': ['1474-7596', '1474-760X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760877', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/18851746', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1186/gb-2008-9-10-r150', 'pdf_url': 'https://genomebiology.biomedcentral.com/counter/pdf/10.1186/gb-2008-9-10-r150', 'source': {'id': 'https://openalex.org/S81160022', 'display_name': 'Genome biology', 'issn_l': '1474-7596', 'issn': ['1474-7596', '1474-760X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320256', 'host_organization_name': 'BioMed Central', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310320256'], 'host_organization_lineage_names': ['Springer Nature', 'BioMed Central'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 51, 'referenced_works': ['https://openalex.org/W1596515083', 'https://openalex.org/W1679913846', 'https://openalex.org/W1748745335', 'https://openalex.org/W1899313383', 'https://openalex.org/W1965948654', 'https://openalex.org/W1969315337', 'https://openalex.org/W1974317126', 'https://openalex.org/W1984823794', 'https://openalex.org/W1998135863', 'https://openalex.org/W2010982295', 'https://openalex.org/W2016620103', 'https://openalex.org/W2022846164', 'https://openalex.org/W2023587649', 'https://openalex.org/W2044033792', 'https://openalex.org/W2057364464', 'https://openalex.org/W2071491707', 'https://openalex.org/W2074324848', 'https://openalex.org/W2095680092', 'https://openalex.org/W2096398040', 'https://openalex.org/W2100471807', 'https://openalex.org/W2106356851', 'https://openalex.org/W2106713259', 'https://openalex.org/W2107418471', 'https://openalex.org/W2109368503', 'https://openalex.org/W2110417418', 'https://openalex.org/W2118681164', 'https://openalex.org/W2121963546', 'https://openalex.org/W2122598723', 'https://openalex.org/W2123641599', 'https://openalex.org/W2127193805', 'https://openalex.org/W2130314846', 'https://openalex.org/W2134830409', 'https://openalex.org/W2135030836', 'https://openalex.org/W2138366746', 'https://openalex.org/W2141762576', 'https://openalex.org/W2144209664', 'https://openalex.org/W2148282250', 'https://openalex.org/W2151384979', 'https://openalex.org/W2158323345', 'https://openalex.org/W2160356867', 'https://openalex.org/W2164078503', 'https://openalex.org/W2171767584', 'https://openalex.org/W2171996338', 'https://openalex.org/W2326266120', 'https://openalex.org/W2327054845', 'https://openalex.org/W2330923897', 'https://openalex.org/W4210241463', 'https://openalex.org/W4237222446', 'https://openalex.org/W4253759977', 'https://openalex.org/W47603266', 'https://openalex.org/W69965022'], 'related_works': ['https://openalex.org/W2973745661', 'https://openalex.org/W2906604078', 'https://openalex.org/W2386816279', 'https://openalex.org/W2151547689', 'https://openalex.org/W2148413097', 'https://openalex.org/W2138809862', 'https://openalex.org/W2104096565', 'https://openalex.org/W2079028380', 'https://openalex.org/W2068676227', 'https://openalex.org/W2024545138'], 'abstract_inverted_index': {'Amplified': [0], 'MYCN': [1, 6, 22, 26, 57, 94, 123, 130, 220], 'oncogene': [2], 'resulting': [3], 'in': [4, 11, 86, 102, 132, 139, 152, 157, 213, 223], 'deregulated': [5], 'transcriptional': [7, 56], 'activity': [8], 'is': [9, 200, 208, 236], 'observed': [10], '20%': [12], 'of': [13, 71, 93, 146, 167, 170, 183, 203, 232], 'neuroblastomas': [14], 'and': [15, 28, 81, 95, 135, 192], 'identifies': [16, 174], 'a': [17, 35, 68, 168, 175, 201, 229], 'highly': [18], 'aggressive': [19], 'subtype.': [20], 'In': [21, 49, 161, 217], 'single-copy': [23], 'neuroblastomas,': [24, 109], 'elevated': [25], 'mRNA': [27], 'protein': [29], 'levels': [30, 99], 'are': [31, 61], 'paradoxically': [32], 'associated': [33, 62, 128], 'with': [34, 63, 129, 163, 178, 239], 'more': [36], 'favorable': [37], 'clinical': [38], 'phenotype,': [39], 'including': [40], 'disseminated': [41], 'tumors': [42, 226], 'that': [43, 89, 235], 'subsequently': [44], 'regress': [45], 'spontaneously': [46], '(stage': [47], '4s-non-amplified).': [48], 'this': [50], 'study,': [51], 'we': [52], 'asked': [53], 'whether': [54], 'distinct': [55], 'or': [58], 'c-MYC': [59, 137, 212], 'activities': [60], 'specific': [64], 'neuroblastoma': [65, 87, 205], 'phenotypes.We': [66], 'defined': [67, 144], 'core': [69], 'set': [70, 145, 231], 'direct': [72], 'MYCN/c-MYC': [73, 110, 147, 171, 196], 'target': [74, 111, 148, 172, 197, 233], 'genes': [75, 149, 173, 234], 'by': [76, 211], 'applying': [77], 'gene': [78, 112, 198], 'expression': [79, 113, 166, 199], 'profiling': [80], 'chromatin': [82], 'immunoprecipitation': [83], '(ChIP,': [84], 'ChIP-chip)': [85], 'cells': [88], 'allow': [90], 'conditional': [91], 'regulation': [92], 'c-MYC.': [96], 'Their': [97], 'transcript': [98], 'were': [100], 'analyzed': [101], '251': [103], 'primary': [104], 'neuroblastomas.': [105, 160], 'Compared': [106], 'to': [107, 122], 'localized-non-amplified': [108], 'gradually': [114], 'increases': [115], 'from': [116], 'stage': [117, 120, 133, 140, 153, 158, 214, 224], '4s-non-amplified': [118, 134, 159, 225], 'through': [119], '4-non-amplified': [121, 141, 154, 215], 'amplified': [124, 188], 'tumors.': [125, 142, 216], 'This': [126], 'was': [127, 150], 'activation': [131, 138], 'predominantly': [136, 209], 'A': [143], 'induced': [151], 'but': [155], 'not': [156], 'line': [162], 'this,': [164], 'high': [165], 'subset': [169], 'patient': [176], 'subtype': [177], 'poor': [179], 'overall': [180], 'survival': [181], 'independent': [182], 'the': [184], 'established': [185], 'risk': [186], 'markers': [187], 'MYCN,': [189], 'disease': [190], 'stage,': [191], 'age': [193], 'at': [194], 'diagnosis.High': [195], 'hallmark': [202], 'malignant': [204], 'progression,': [206], 'which': [207], 'driven': [210], 'contrast,': [218], 'moderate': [219], 'function': [221], 'gain': [222], 'induces': [227], 'only': [228], 'restricted': [230], 'still': [237], 'compatible': [238], 'spontaneous': [240], 'regression.': [241]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2138809862', 'counts_by_year': [{'year': 2024, 'cited_by_count': 14}, {'year': 2023, 'cited_by_count': 27}, {'year': 2022, 'cited_by_count': 16}, {'year': 2021, 'cited_by_count': 22}, {'year': 2020, 'cited_by_count': 15}, {'year': 2019, 'cited_by_count': 12}, {'year': 2018, 'cited_by_count': 11}, {'year': 2017, 'cited_by_count': 16}, {'year': 2016, 'cited_by_count': 11}, {'year': 2015, 'cited_by_count': 15}, {'year': 2014, 'cited_by_count': 13}, {'year': 2013, 'cited_by_count': 11}, {'year': 2012, 'cited_by_count': 13}], 'updated_date': '2024-12-14T16:37:16.859154', 'created_date': '2016-06-24'}