Publication Information

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'testing': [137], 'identify': [139, 2195], 'individuals': [140, 2274], 'at': [141, 344, 397, 2041, 2441, 2472], 'greatest': [142], 'susceptibility': [143, 320, 528, 1616], 'diseases': [146, 291], 'possibilities': [149], 'raises': [151, 328], 'disease': [153, 253, 342, 532, 555, 591, 1262, 1264, 1709, 2073, 2087, 2261], 'prevention.': [154], 'Application': [155, 1967], 'context': [160], 'moves': [161], 'away': [162, 648, 1634], 'clinic': [165], 'towards': [166, 655, 2670], 'population': [168, 252, 346, 534, 1973, 2043], 'observational': [171], 'methods': [172, 502, 1010, 1434, 1701], 'epidemiology.': [174, 880, 1406], 'fruit': [176], 'terms': [181], 'reduced': [183], 'morbidity': [184], 'mortality': [186], 'is': [187, 197, 321, 443, 456, 478, 520, 543, 710, 796, 1004, 1034, 1090, 1098, 1114, 1177, 1218, 1547, 1552, 1593, 1638, 1654, 1666, 1676, 1782, 1793, 2065, 2145, 2161, 2189, 2269, 2413, 2517, 2612], 'therefore': [188, 2389], 'be': [190, 325, 557, 581, 817, 892, 1049, 1134, 1200, 1209, 1725, 1917, 2039, 2089, 2101, 2422, 2433, 2449, 2467, 2555, 2615, 2644, 2750], 'predominantly': [191, 1418], 'realized': [192], 'through': [193, 788, 1477, 2461], 'health': [195, 298, 990], 'measures.It': [196], 'well': [198, 685, 2629, 2645], 'known': [199, 2175], 'majority': [202, 258], 'variants': [205], 'or': [206, 357, 426, 578, 1289, 1439, 1483, 1520, 1733, 1747, 1807, 2136, 2182, 2429, 2456, 2476, 2564], 'single': [207, 238, 782, 1150], 'nucleotide': [208, 239, 783, 1151], 'polymorphisms': [209, 240, 784, 1152], 'are': [214, 273, 279, 496, 512, 785, 966, 1702, 1778, 1958], 'low': [216, 245, 275, 2442], 'penetrance,': [217, 246], 'genes': [219, 975, 1819, 1826, 1863, 1886, 1934, 1984, 2002, 2058], 'metabolism': [222], 'environmental': [224, 268, 484, 491, 605, 869, 1018, 1070, 1473, 1566, 1648, 1696, 1750, 1965, 2719, 2741], 'chemicals,': [225], 'immunity,': [226], 'lipid': [227], 'metabolism,': [228], 'hemostasis': [230], 'among': [231, 2566], 'others.': [232], 'high': [234, 441], 'prevalence': [235], 'these': [237, 671, 716, 1310, 1700, 1956, 2046, 2264, 2490], 'means': [241], 'despite': [243], 'their': [244, 1739, 2533, 2621, 2784], 'they': [247, 383, 679, 853, 2407], 'substantially': [249, 1497], 'contribute': [250], 'burden': [254, 299], '(2).': [255], 'Nevertheless,': [256, 1216], 'will': [259, 338, 391, 469, 803, 1198, 1206, 1724, 2448, 2554, 2706], 'do': [260, 1813, 2097], 'so': [261], 'only': [262, 322, 729, 1199, 1326], 'presence': [265], 'specific': [267, 1369, 1722, 1745, 1862, 1876, 1907, 2061, 2174, 2241, 2434], 'exposures': [269, 278, 492, 870, 1071, 1723, 1751, 2387, 2440], 'themselves': [272], 'penetrance.': [276], 'Environmental': [277], 'acknowledged': [280], 'play': [282, 2699], 'an': [283, 828, 872, 1016, 1037, 1046, 1146, 2527, 2656, 2685, 2744], 'overwhelmingly': [284], 'important': [285, 1959, 2450], 'role': [286, 1308, 2697], 'those': [288, 1891, 2083], 'common': [289, 2102, 2470, 2480], 'mentioned': [292, 2292], 'above,': [293], 'which': [294, 576, 1558, 1913, 2228], 'constitute': [295, 2120], 'major': [297, 642, 2156], 'economically': [301], 'developed': [302], 'countries': [303, 1193], '(3,': [304], '4).': [305], 'Despite': [306], 'this,': [307], 'many': [308, 868, 1472, 2758], 'exposure-disease': [309, 1504], 'associations': [310], 'remain': [311], 'ill': [312], 'defined': [313, 583], 'complex': [316, 483, 2454], 'interplay': [317, 780], 'with': [318, 713, 734, 833, 946, 1011, 1160, 1211, 1612, 1738, 1798, 1810, 2006, 2019, 2069, 2084, 2107, 2286, 2330, 2526, 2593, 2605, 2684], 'beginning': [323], 'addressed.': [326], 'question': [330], 'as': [331, 799, 856, 1020, 1159, 1232, 1340, 1392, 1525, 1568, 1890, 2011, 2586, 2628, 2630], 'whether': [333, 1680, 1721, 2406, 2453], 'fundamental': [334], 'about': [336], 'improve': [339, 599], 'understanding': [340, 1167, 1305, 1707], 'etiology': [343, 577], 'level.The': [347], 'new': [348, 1682, 1766, 2397, 2689], 'generation': [349, 1409, 2398, 2596, 2680, 2690], 'mega-cohort': [351], 'studies,': [352, 535, 2611], 'Biobank': [356, 390], 'similar': [358, 1818], 'proposed': [359], 'US': [360], 'Asian': [362, 429], 'cohorts': [363], '(5-8),': [364], 'framework': [367], 'such': [369, 1085, 1391, 1478, 2010, 2036], 'investigations': [370, 1508, 2104], 'variation,': [373, 2357], 'environment,': [374], 'lifestyle,': [375], 'disease.': [378], 'At': [379], 'same': [381, 1013, 1889, 2463], 'time,': [382, 683], 'represent': [384], 'substantial': [385, 1172], 'investment.': [386], 'recruit': [392], 'half': [393, 885], 'million': [395, 403, 419, 1149], 'people': [396, 420], 'cost': [399, 442], 'around': [401, 1720], '£60': [402], '($110': [404], 'million)': [405], 'initial': [408, 1914], 'phase.': [409], 'proposal': [411], 'establish': [413, 1281], '"Last': [415], 'Cohort"': [416], '1': [418], 'United': [423], 'States': [424], '(7)': [425], 'similar-sized': [428], 'cohort': [430, 1001, 1221, 2624], '(8)': [431], 'would': [432, 1028, 2641, 2768], 'presumably': [433], 'exceed': [434], 'sum.': [436], 'In': [437, 586, 905, 1157, 1271, 1534, 1657, 1850, 2507, 2721], 'each': [438, 2488], 'case,': [439], 'heavily': [444], 'influenced': [445], 'by': [446, 559, 673, 725, 754, 759, 923, 1254, 1344, 1727, 1903, 2169, 2251, 2337, 2469, 2620], 'collection': [448, 1256], 'banking': [450], 'biological': [452, 1501], 'material.': [453], 'expense': [455], 'predicated': [457], 'assumption': [460], 'molecular': [464, 540, 567, 696, 1414], 'measures': [465, 2739], 'material': [468], 'resolve': [470], 'etiologic': [472, 1307, 1545, 1652], 'questions': [473], 'alluded': [474], 'above.': [476, 2214], 'It': [477, 795, 1113, 1929, 2419, 2447], 'self-evident': [479], 'unraveling': [481], 'aetiologies': [487], 'demands': [488, 668], 'both': [490, 1760, 1955], 'variation': [495, 2329], 'reliably': [497], 'measured.': [498], 'Advances': [499], 'statistical': [501, 2583], 'bioinformatics': [505], 'relation': [507], 'large': [509, 900, 2537], 'data': [510, 838, 846, 1900, 2238, 2352], 'sets': [511], 'critical': [515], 'importance.The': [516], 'development': [517, 650], 'biomarkers': [519, 654, 1183, 1197, 1402, 1412, 1461, 1524, 1540, 1650], 'one': [521, 884, 924, 1139, 1789], 'avenue': [522], 'measurement': [525, 601, 882, 972, 1082], 'exposure,': [527, 1390], '(including': [529, 1072], 'genetic),': [530], 'field': [538], 'cancer': [541, 697, 879, 1415, 1582, 1589], 'epidemiology': [542, 1265, 1380, 1416], 'founded': [544], 'trinity': [547], 'biomarker': [549, 1229, 1561], 'categories': [550], '(9).': [551], 'characterization': [553, 2671], 'can': [556, 580, 1170, 1690, 1916, 2408, 2432, 2466], 'modern': [560], 'histopathology,': [561], 'particularly': [562], 'application': [564, 790, 1537, 1963, 2272, 2380, 2535], 'sophisticated': [566, 2582], 'markers': [568, 1388, 1603], 'subcategorize': [570], 'tumors': [571], 'homogenous': [573], 'groups': [574], 'within': [575], 'better': [582], '(10,': [584], '11).': [585], 'parallel': [587, 843], 'advances': [589, 844, 2705], 'classification,': [592], 'however,': [593], 'balance': [595, 2666], 'efforts': [597], 'risk': [606, 909, 1190, 1474, 2742], 'factors': [607, 1475, 2009], 'has': [608, 620, 978, 1121, 1266, 1301, 1456, 1494, 2694], 'dramatically': [609], 'changed': [610, 2276], 'over': [611, 682, 2505], 'last': [613], '15': [614], 'years': [615, 1328], 'way': [618, 1911], 'been': [621, 722, 751, 1122, 1302, 1457, 1632, 2111], 'less': [622, 1386, 1458, 2751], 'than': [623, 1137, 2757], 'ideal.The': [624], 'ease': [625], 'genotyping': [627], 'following': [628], 'introduction': [630], 'PCR': [633], 'late': [636], '1980s': [637], '1990s': [639], 'saw': [640], 'shift': [643], 'effort': [645, 2668], 'resources,': [647], 'accurate': [652, 865], 'exposure': [653, 1019, 1061, 1088, 1169, 1182, 1228, 1245, 1269, 1404, 1411, 1463, 1539, 1560, 1611, 1628, 1649, 1697, 1716, 1776, 1838, 2095, 2417, 2496, 2598, 2650], 'conduct': [657], 'gene-disease': [659, 699], 'association': [660, 700, 1511], 'studies.': [661, 1002, 1314], 'Allied': [662], 'relatively': [665, 735, 1655, 1794], 'trivial': [666], 'technical': [667], 'genotyping,': [670, 863], 'measures,': [672], 'consequence': [674, 814, 858], 'fact': [677], 'were': [680, 684, 1827, 1887, 1901, 1985, 1988, 2028, 2234, 2344], 'unchanging': [681], 'suited': [686], 'classic': [688], 'case-control': [689], 'study': [690, 748, 1222, 2021, 2220], 'design.': [691], 'laboratories': [693], 'involved': [694], 'epidemiology,': [698], 'studies': [701, 719, 808, 1532, 1546, 1653, 1803, 1866, 1897, 2047, 2625], 'offered': [702], 'rapid': [703], 'gains': [704], 'output.': [707], 'literature': [709], 'now': [711, 786], 'replete': [712], 'meta-analyses': [714], 'data.': [717], 'have': [721, 750, 1022, 1604, 1631, 2110], 'conducted': [723], 'have,': [724], 'some': [726, 1601, 1882, 1933, 2049, 2391, 2499, 2637], 'accounts,': [727], 'yielded': [728], 'modicum': [731], 'success': [733], 'few': [736], 'reproducible': [737], 'findings': [738, 826], '(see': [739], 'example': [741, 1176, 1556, 2216], 'ref.': [742], '12).': [743], 'More': [744], 'recently,': [745], 'improvements': [746], 'design': [749, 1223], 'suggested,': [752], 'notably': [753], 'increasing': [755, 829, 2170, 2708], 'subject': [756, 897, 2289], 'numbers': [757, 2538], 'analyzing': [760], 'multiple': [761], 'polymorphisms,': [762], 'functional': [764], 'relevance': [765], '(13).': [766], 'A': [767, 1822], 'comprehensive': [769], 'coverage': [770], 'possibility': [776], 'examine': [778, 2326], 'between': [781, 1330, 1512, 1953, 1992, 2710], 'feasible': [787], 'microarray': [792, 1834, 1970], 'technology': [793, 1767, 2037, 2525], '(14).': [794], 'predictable': [797], 'costs': [800], 'decrease,': [801], 'there': [802, 1033, 1665, 1947, 2294, 2516], 'emerge': [804], 'analyses': [805, 2025], 'existing': [807], 'grander': [811], 'scale.': [812], 'not': [816, 1115, 1133, 1943, 2004, 2098, 2575], 'greater': [818, 822], 'clarity': [819], 'but': [820, 942, 1942], 'number': [823, 1643, 2172], 'chance': [825], 'difficulty': [830], 'dealing': [832], 'sheer': [835], 'volume': [836], 'absence': [841], 'analysis.': [847, 1928], 'Things': [848], 'get': [850, 854], 'worse': [851], 'before': [852, 2404], 'better.Partially': [855], 'emphasis': [861, 1429, 1459, 1488], 'assessment': [866, 1717, 2096, 2651], 'remains': [871, 896, 2420], 'outstanding': [873], 'largely': [875], 'unmet': [876], 'challenge': [877, 1131], 'As': [881, 2018, 2285, 2592], 'gene:environment': [888], 'equation': [889], 'continues': [890], 'refined,': [893], 'other': [895, 1467], 'degree': [901], 'misclassification': [903], '(15).': [904], 'imbalance,': [907], 'we': [908, 1021], 'adopting': [910], 'image': [912], 'male': [915], 'fiddler': [916, 964], 'crab': [917, 965], '(Uca': [918], 'pugnax),': [919], 'species': [921], 'characterized': [922], 'huge': [925], 'well-developed': [926], 'claw': [927], '(growing': [928], '65%': [930], 'its': [932, 947, 1063, 1338], 'total': [933], 'body': [934, 1451, 1873], 'weight)': [935], 'waved': [936], 'proudly': [937], 'attract': [939], 'mate,': [941], 'contrasting': [943], 'almost': [944], 'comically': [945], 'second,': [948, 1945], 'apparently': [949], 'underdeveloped': [950], 'one;': [951], 'analogy': [953], 'breaks': [954], 'down': [955], 'course': [957], 'claws': [961], 'adapted': [967], 'purpose.The': [969], 'imbalance': [970], 'precision': [973, 1014], 'environment': [977], 'consequences,': [979], 'most': [980, 1064, 2616], 'fundamentally': [981], 'compromising': [983], 'ability': [985], 'fully': [987], 'derive': [988], 'benefits': [991], 'expenditure': [993], 'aforementioned': [1000], 'There': [1003, 1455], 'desperate': [1006], 'need': [1007, 1035, 1056, 1207, 1669, 2520, 2580], 'develop': [1009], "individual's": [1017, 1025], 'I': [1027], 'like': [1029, 2063, 2769], 'suggest': [1031], '"exposome"': [1038], 'match': [1040], '"genome."': [1042], 'concept': [1044, 2654], 'exposome': [1047, 1067, 1097, 2657], 'useful': [1050], 'drawing': [1052], 'methodologic': [1058, 1130], 'developments': [1059], 'assessment.At': [1062], 'complete,': [1065], 'encompasses': [1068], 'life-course': [1069], 'lifestyle': [1073], 'factors),': [1074], 'prenatal': [1077], 'period': [1078], 'onwards.': [1079], 'Developing': [1080], 'reliable': [1081, 2649], 'tools': [1083], 'complete': [1087], 'extremely': [1091], 'challenging.': [1092], 'Unlike': [1093], 'genome,': [1095, 1162], 'highly': [1100], 'variable': [1101], 'dynamic': [1103, 2485], 'entity': [1104], 'evolves': [1106], 'throughout': [1107], 'lifetime': [1109], 'individual.': [1112], 'without': [1116, 2086], 'good': [1117], 'cause': [1118], 'progress': [1120, 1592], 'limited': [1123, 2543], 'meeting': [1125], 'goal.': [1127], 'daunting': [1136], 'faced': [1140], 'two': [1141, 2334], 'decades': [1142], 'ago': [1143], 'investigating': [1145], 'estimated': [1147, 2146], '10': [1148], 'addition,': [1158, 2722], 'even': [1163, 1622], 'partial,': [1165], 'targeted': [1166], 'provide': [1171, 2048, 2409], 'advances;': [1173], 'prime': [1175, 1555], 'contribution': [1179], 'aflatoxin': [1181], 'assignment': [1186], 'hepatocellular': [1188], 'carcinoma': [1189], 'developing': [1192, 2648], '(16).': [1194], 'Of': [1195, 2266], 'course,': [1196], 'part': [1201], 'solution': [1204], 'coupled': [1210, 1247, 2139], 'increasingly': [1212], 'refined': [1213], 'questionnaire-based': [1214], 'approaches.': [1215], 'prospective': [1220, 2623], 'best': [1225], 'suits': [1226], 'approach,': [1230], 'providing': [1231], 'does': [1234], 'repeat': [1237], 'sampling': [1238], 'enable': [1240], 'broader': [1242], 'timeframe': [1243], 'assessment,': [1246, 2497], 'avoidance': [1250], 'reverse': [1252, 1904], 'causation': [1253], 'samples': [1258], 'advance': [1260], 'onset.Infectious': [1263], 'extensively': [1267], 'employed': [1268], 'biomarkers.': [1270], 'case': [1273, 1319, 1353, 2549], 'infections': [1275], 'developmental': [1278], 'work': [1279], 'validated': [1282], 'laboratory': [1283, 2717], 'assays': [1284], 'antibodies': [1286], 'viral': [1288], 'bacterial': [1290], 'antigens': [1291], '(e.g.,': [1292, 1480], 'hepatitis': [1293, 1355], 'viruses,': [1294], 'papilloma': [1296], 'virus,': [1297], 'Helicobacter': [1299], 'pylori)': [1300], 'central': [1303], 'agents': [1311], 'epidemiologic': [1313], 'H.': [1321], 'pylori': [1322], 'gastric': [1324], '11': [1327], 'elapsed': [1329], 'organism': [1334], '1983': [1336], 'classification': [1339], 'carcinogen': [1343, 1448, 1571], 'IARC': [1346], '1994': [1348], '(17).': [1349], 'Similarly,': [1350], 'B': [1356, 1374], 'virus': [1357], 'liver': [1359], 'availability': [1364], 'sensitive': [1367, 2436], 'marker': [1370], 'infection': [1372], '(hepatitis': [1373], 'surface': [1375], 'antigen)': [1376], 'transformed': [1378], 'had': [1382], 'earlier': [1383, 2595], 'relied': [1384], 'precise': [1387, 1401], 'clinical': [1393], 'history.': [1394], 'These': [1395], 'examples': [1396], 'illustrate': [1397], 'value': [1399], 'first': [1408, 1938], 'derived': [1419], 'paradigm': [1422], 'chemical': [1424, 2181, 2185], 'carcinogenesis.': [1425], 'led': [1427], 'genotoxic': [1431, 1761], 'chemicals': [1432, 2459], 'measure': [1436, 2558], 'carcinogen-DNA': [1437], 'adducts': [1438, 1441, 1493, 1579, 1586], 'carcinogen-protein': [1440], '(as': [1442, 2320], 'surrogates': [1443], 'DNA': [1445, 1490, 1833, 1969], 'adducts)': [1446], 'metabolites': [1449, 2118, 2157, 2176, 2372, 2565], 'fluids': [1452], '(18,': [1453], '19).': [1454], 'light': [1465], 'nongenotoxic,': [1468], 'mechanistic': [1469, 1618, 2481], 'paradigms,': [1470], 'although': [1471, 2103], 'act': [1476, 2460], 'mechanisms': [1479, 1710, 1757, 2262], 'receptor-mediated': [1481], 'effects': [1482, 2358], 'alterations': [1484, 1858], 'cell': [1486, 1846], 'proliferation).The': [1487], 'undoubtedly': [1495], 'contributed': [1496], 'establishing': [1499], 'plausibility': [1502], 'associations.': [1505], 'Examples': [1506], 'include': [1507, 1575], 'genotypes': [1513], 'carcinogen-metabolizing': [1515], 'enzymes': [1516], 'adduct': [1518], 'levels,': [1519], 'modifiable': [1526], 'end': [1527], 'points': [1528], 'short-term': [1530], 'intervention': [1531], '(20).': [1533], 'contrast,': [1535], 'nature': [1543, 2486], 'far': [1548], 'limited.': [1550], 'Aflatoxin': [1551], 'perhaps': [1553], 'permitted': [1562], 'categorization': [1563], 'agent': [1567], '(21,': [1572], '22),': [1573], 'others': [1574, 2759], 'polycyclic': [1576], 'aromatic': [1577], 'hydrocarbon-DNA': [1578], 'lung': [1581], '(23)': [1583], 'arylamine-hemoglobin': [1585], 'bladder': [1588], '(24).': [1590], 'Valuable': [1591], 'still': [1594, 1639], 'being': [1595, 2066, 2249], 'made': [1596], 'area': [1599, 1785, 2745], 'chemical-specific': [1602], 'advantage': [1606], 'combining': [1608], 'information': [1609, 2259], 'insights': [1613], 'into': [1614, 1651], 'individual': [1615], '(25).': [1620], 'accepting': [1623], 'researchers': [1625], 'arena': [1629], 'might': [1630, 2038], 'enticed': [1633], 'genotype,': [1636], 'striking': [1640], 'successful': [1645, 2617], 'applications': [1646, 2092], 'modest.': [1656], 'addition': [1658, 2508], 'call': [1661], 'commitment,': [1664], 'novel': [1671], 'approaches.In': [1672], 'context,': [1674], 'pertinent': [1677], 'ask': [1679], '"omics"': [1683, 1737, 2382, 2692], 'technologies': [1684, 2383, 2400], 'transcriptomics,': [1686, 2064], 'proteomics,': [1687], 'metabonomics': [1689], 'help': [1691], 'unlock': [1692], 'problem': [1694], 'assessment.': [1698, 2418], 'Currently,': [1699, 2091], 'mainly': [1703], 'applied': [1704], 'diagnosis.': [1712], 'Their': [1713], 'validity': [1714], 'primarily': [1718, 2067], 'revolves': [1719], 'reflected': [1726], 'altered': [1728, 2196], 'levels': [1729, 2443], 'mRNA,': [1731, 2427, 2474], 'proteins,': [1732], 'metabolites.': [1734], 'Will': [1735], 'thousands': [1740], 'composite': [1742], 'parts': [1743], 'signatures': [1746], 'fingerprints': [1748, 2233], 'across': [1752], 'broad': [1754, 2762], 'spectrum': [1755], 'action,': [1759], 'nongenotoxic?': [1763], 'Is': [1764], 'position': [1770], 'permit': [1772, 2082], 'step-change': [1774, 2411], 'assessment?There': [1777], 'indications': [1779], 'fruitful': [1784], 'research,': [1787], 'albeit': [1788], 'date': [1792], 'unexplored.': [1795], 'respect': [1799], 'mRNA': [1801, 2027], 'expression,': [1802], 'naturally': [1805], 'occurring': [1806], 'industrial': [1808], 'compounds': [1809, 1843], 'estrogen': [1811], 'activity': [1812], 'alter': [1814], 'vitro.': [1821], 'panel': [1823, 1979], '172': [1825], 'selected': [1828], 'create': [1830], 'customized': [1832], 'responded': [1836, 1935], 'class': [1841, 2183], 'model': [1847, 2606], 'system': [1848], '(26).': [1849], 'vitro': [1851, 1896, 2106], 'ionizing': [1852, 2023], 'irradiation': [1853, 1874, 2291], 'lymphocytes': [1856, 1868], 'induced': [1857], '(27).': [1864], 'Subsequent': [1865], 'patients': [1870, 2288], 'undergoing': [1871], 'whole': [1872], 'revealed': [1875], 'patterns': [1877, 2197], 'induction': [1880], 'affected': [1885, 2250], 'identified': [1892, 1986], '(28).': [1898], 'Microarray': [1899], 'confirmed': [1902], 'transcription-PCR': [1905], 'genes,': [1908], 'illustrating': [1909, 2253], 'screening': [1915], 'translated': [1918], 'low-density': [1920], 'arrays': [1921, 2212], 'subsets': [1924], 'routine': [1927], 'noteworthy': [1931], 'dose': [1939], 'radiation': [1941, 2109], 'considerable': [1949, 2296, 2522], 'heterogeneity': [1950, 2300], 'response': [1952], 'patients;': [1954], 'observations': [1957], 'when': [1960, 1977], 'thinking': [1961], 'exposures.': [1966], 'setting': [1974], 'shown': [1976], '36': [1981], 'candidate': [1982], 'reporter': [1983, 2001], 'able': [1989], 'discriminate': [1991], 'smokers': [1993], 'nonsmokers': [1995], '(29).': [1996], 'Importantly,': [1997], 'correlated': [2005], 'confounding': [2008], 'alcohol,': 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