Title: Transketolase Activity in Experimental Thiamine Deficiency and Hepatic Necrosis.
Abstract: Transketolase activity in rat liver and red blood cells is decreased at a significantly slower rate than circulating or tissue thiamine in dietary-induced thiamine deficiency; superimposition of carbon tetrachloride-induced liver necrosis on thiamine deficiency increases the disparity between alterations of vitamin and enzyme levels. Replacement therapy in thiamine deficient animals with a normal liver only slowly restores tissue thiamine and transketolase; in the presence of active liver necrosis low tissue vitamin and enzyme levels persist despite administration of thiamine.
Publication Year: 1964
Publication Date: 1964-08-01
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 28
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