Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W21385414', 'doi': 'https://doi.org/10.1007/978-3-7091-6499-0_25', 'title': 'Studies on the behaviour of semicarbazide-sensitive amine oxidase in Sprague-Dawley rats treated with the monoamine oxidase inhibitor tranylcypromine', 'display_name': 'Studies on the behaviour of semicarbazide-sensitive amine oxidase in Sprague-Dawley rats treated with the monoamine oxidase inhibitor tranylcypromine', 'publication_year': 1998, 'publication_date': '1998-01-01', 'ids': {'openalex': 'https://openalex.org/W21385414', 'doi': 'https://doi.org/10.1007/978-3-7091-6499-0_25', 'mag': '21385414', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9564625'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/978-3-7091-6499-0_25', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210178778', 'display_name': 'Journal of neural transmission. Supplementum', 'issn_l': '0303-6995', 'issn': ['0303-6995'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'book series'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'book-chapter', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5009000972', 'display_name': 'Deirdre Fitzgerald‐Hughes', 'orcid': 'https://orcid.org/0000-0002-4843-3839'}, 'institutions': [{'id': 'https://openalex.org/I205274468', 'display_name': 'Trinity College Dublin', 'ror': 'https://ror.org/02tyrky19', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I205274468']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'D. H. Fitzgerald', 'raw_affiliation_strings': ['Department of Biochemistry, Trinity College Dublin 2, Ireland'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Trinity College Dublin 2, Ireland', 'institution_ids': ['https://openalex.org/I205274468']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047695717', 'display_name': 'Keith F. Tipton', 'orcid': 'https://orcid.org/0000-0001-8855-5315'}, 'institutions': [{'id': 'https://openalex.org/I205274468', 'display_name': 'Trinity College Dublin', 'ror': 'https://ror.org/02tyrky19', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I205274468']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'K. F. Tipton', 'raw_affiliation_strings': ['Department of Biochemistry, Trinity College Dublin 2, Ireland'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry, Trinity College Dublin 2, Ireland', 'institution_ids': ['https://openalex.org/I205274468']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5028617741', 'display_name': 'Geoffrey A. Lyles', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802526638', 'display_name': 'Ninewells Hospital', 'ror': 'https://ror.org/039c6rk82', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800860831', 'https://openalex.org/I2802526638']}, {'id': 'https://openalex.org/I177639307', 'display_name': 'University of Dundee', 'ror': 'https://ror.org/03h2bxq36', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I177639307']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'G. A. Lyles', 'raw_affiliation_strings': ['Department of Pharmacology and Clinical Pharmacology, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Clinical Pharmacology, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, UK', 'institution_ids': ['https://openalex.org/I2802526638', 'https://openalex.org/I177639307']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 7, 'citation_normalized_percentile': {'value': 0.44791, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 75, 'max': 76}, 'biblio': {'volume': None, 'issue': None, 'first_page': '259', 'last_page': '264'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12688', 'display_name': 'Biological Methane Utilization and Metabolism', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12688', 'display_name': 'Biological Methane Utilization and Metabolism', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/tranylcypromine', 'display_name': 'Tranylcypromine', 'score': 0.9627257}, {'id': 'https://openalex.org/keywords/semicarbazide', 'display_name': 'Semicarbazide', 'score': 0.68721706}, {'id': 'https://openalex.org/keywords/biogenic-amine', 'display_name': 'Biogenic amine', 'score': 0.47695982}, {'id': 'https://openalex.org/keywords/monoamine-oxidase-b', 'display_name': 'Monoamine oxidase B', 'score': 0.42121166}, {'id': 'https://openalex.org/keywords/metabolic-engineering', 'display_name': 'Metabolic Engineering', 'score': 0.420506}], 'concepts': [{'id': 'https://openalex.org/C2777118369', 'wikidata': 'https://www.wikidata.org/wiki/Q420885', 'display_name': 'Tranylcypromine', 'level': 4, 'score': 0.9627257}, {'id': 'https://openalex.org/C2776024655', 'wikidata': 'https://www.wikidata.org/wiki/Q410867', 'display_name': 'Monoamine oxidase', 'level': 3, 'score': 0.88098204}, {'id': 'https://openalex.org/C2778627024', 'wikidata': 'https://www.wikidata.org/wiki/Q417535', 'display_name': 'Semicarbazide', 'level': 2, 'score': 0.68721706}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.51718533}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.50748366}, {'id': 'https://openalex.org/C2778377861', 'wikidata': 'https://www.wikidata.org/wiki/Q424455', 'display_name': 'Biogenic amine', 'level': 4, 'score': 0.47695982}, {'id': 'https://openalex.org/C28212737', 'wikidata': 'https://www.wikidata.org/wiki/Q5381543', 'display_name': 'Enzyme assay', 'level': 3, 'score': 0.42992905}, {'id': 'https://openalex.org/C39398028', 'wikidata': 'https://www.wikidata.org/wiki/Q18028862', 'display_name': 'Monoamine oxidase B', 'level': 4, 'score': 0.42121166}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.41503152}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.40531564}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3742876}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.31532076}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.21570852}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.19767892}, {'id': 'https://openalex.org/C2776219046', 'wikidata': 'https://www.wikidata.org/wiki/Q162657', 'display_name': 'Neurotransmitter', 'level': 3, 'score': 0.18610358}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.07464656}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D006631', 'descriptor_name': 'Amine Oxidase (Copper-Containing)', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D008995', 'descriptor_name': 'Monoamine Oxidase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008996', 'descriptor_name': 'Monoamine Oxidase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': True}, {'descriptor_ui': 'D014191', 'descriptor_name': 'Tranylcypromine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000499', 'descriptor_name': 'Allylamine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000499', 'descriptor_name': 'Allylamine', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': False}, {'descriptor_ui': 'D000499', 'descriptor_name': 'Allylamine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006631', 'descriptor_name': 'Amine Oxidase (Copper-Containing)', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006631', 'descriptor_name': 'Amine Oxidase (Copper-Containing)', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001011', 'descriptor_name': 'Aorta', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D001011', 'descriptor_name': 'Aorta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001921', 'descriptor_name': 'Brain', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007527', 'descriptor_name': 'Isoenzymes', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': False}, {'descriptor_ui': 'D007527', 'descriptor_name': 'Isoenzymes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008099', 'descriptor_name': 'Liver', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008995', 'descriptor_name': 'Monoamine Oxidase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008996', 'descriptor_name': 'Monoamine Oxidase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009131', 'descriptor_name': 'Muscle, Smooth, Vascular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014191', 'descriptor_name': 'Tranylcypromine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1007/978-3-7091-6499-0_25', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210178778', 'display_name': 'Journal of neural transmission. Supplementum', 'issn_l': '0303-6995', 'issn': ['0303-6995'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'book series'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9564625', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.66, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 15, 'referenced_works': ['https://openalex.org/W1558022920', 'https://openalex.org/W164399760', 'https://openalex.org/W1931330302', 'https://openalex.org/W1973458038', 'https://openalex.org/W1979492404', 'https://openalex.org/W1992727880', 'https://openalex.org/W2018906271', 'https://openalex.org/W2054637867', 'https://openalex.org/W2058544813', 'https://openalex.org/W2063523536', 'https://openalex.org/W2090848884', 'https://openalex.org/W2091039013', 'https://openalex.org/W2400027464', 'https://openalex.org/W2425481464', 'https://openalex.org/W4256511845'], 'related_works': ['https://openalex.org/W3166894909', 'https://openalex.org/W2472345533', 'https://openalex.org/W21385414', 'https://openalex.org/W2067190092', 'https://openalex.org/W2061410718', 'https://openalex.org/W2060274580', 'https://openalex.org/W2030112195', 'https://openalex.org/W2011979987', 'https://openalex.org/W2003049701', 'https://openalex.org/W116902245'], 'abstract_inverted_index': {'SummaryThe': [0], 'possibility': [1], 'that': [2], 'increased': [3, 73], 'levels': [4], 'of': [5, 8, 22, 31, 55, 97, 112, 114, 127], 'the': [6, 9, 20, 28, 37, 45, 67, 77, 95, 98], 'activity': [7, 26, 69, 116], 'semicarbazide-sensitive': [10], 'amine': [11], 'oxidase': [12, 24], '(SSAO)': [13], 'might,': [14], 'to': [15, 124], 'some': [16], 'extent,': [17], 'compensate': [18], 'for': [19, 84, 131], 'loss': [21], 'monoamine': [23], '(MAO)': [25], 'in': [27, 52, 60, 70, 102], 'atypical': [29], 'form': [30], 'Norrie': [32], 'Disease,': [33], 'was': [34, 82, 100], 'examined': [35], 'using': [36], 'rat': [38, 106], 'as': [39], 'a': [40, 125], 'model.': [41], 'Long-term': [42], 'treatment': [43], 'with': [44], 'MAO': [46], 'inhibitor': [47], 'tranylcypromine': [48], '(1': [49], 'mg/kg/day)': [50], 'resulted': [51], 'sustained': [53], 'inhibition': [54, 119], 'MAO-A': [56], 'and': [57, 62], 'MAO-B': [58], 'activities': [59], 'liver': [61], 'brain.': [63], 'After': [64], 'one': [65], 'week,': [66], 'SSAO': [68], 'heart': [71], 'had': [72], 'by': [74, 120], '79%': [75], 'above': [76], 'control': [78], 'levels.': [79], 'This': [80], 'increase': [81], 'maintained': [83], '3': [85], 'weeks.': [86], 'Since': [87], 'such': [88], 'alterations': [89], 'might': [90], 'result': [91], 'from': [92, 105], 'enzyme': [93, 99, 115], 'induction,': [94], 'turnover': [96], 'studied': [101], 'cultured': [103], 'cells': [104], 'aortic': [107], 'smooth': [108], 'muscle.': [109], 'The': [110], 'time-course': [111], 'recovery': [113], 'following': [117], 'irreversible': [118], 'MDL': [121], '72145': [122], 'corresponded': [123], 'half-life': [126], 'approximately': [128], '6': [129], 'days': [130], 'this': [132], 'process.': [133]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W21385414', 'counts_by_year': [], 'updated_date': '2024-08-15T10:21:51.543082', 'created_date': '2016-06-24'}