Publication Information

{'id': 'https://openalex.org/W2138488546', 'doi': 'https://doi.org/10.1046/j.1365-2958.1999.01515.x', 'title': 'Resistance mutations reveal the atovaquone‐binding domain of cytochrome <i>b</i> in malaria parasites', 'display_name': 'Resistance mutations reveal the atovaquone‐binding domain of cytochrome <i>b</i> in malaria parasites', 'publication_year': 1999, 'publication_date': '1999-08-01', 'ids': {'openalex': 'https://openalex.org/W2138488546', 'doi': 'https://doi.org/10.1046/j.1365-2958.1999.01515.x', 'mag': '2138488546', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10447880'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1046/j.1365-2958.1999.01515.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2958.1999.01515.x', 'source': {'id': 'https://openalex.org/S102549058', 'display_name': 'Molecular Microbiology', 'issn_l': '0950-382X', 'issn': ['0950-382X', '1365-2958'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2958.1999.01515.x', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5112501357', 'display_name': 'Indresh K. Srivastava', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Indresh K. Srivastava', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, 2900 Queen Lane, MCP Hahnemann School of Medicine, Philadelphia, PA 19129, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, 2900 Queen Lane, MCP Hahnemann School of Medicine, Philadelphia, PA 19129, USA.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004953286', 'display_name': 'Joanne M. Morrisey', 'orcid': None}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joanne M. Morrisey', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, 2900 Queen Lane, MCP Hahnemann School of Medicine, Philadelphia, PA 19129, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, 2900 Queen Lane, MCP Hahnemann School of Medicine, Philadelphia, PA 19129, USA.', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105526814', 'display_name': 'Élisabeth Darrouzet', 'orcid': 'https://orcid.org/0000-0002-7176-0862'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Elisabeth Darrouzet', 'raw_affiliation_strings': ['Department of Biology, University of Pennsylvania, Philadelphia, Pa. 19104 USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, University of Pennsylvania, Philadelphia, Pa. 19104 USA', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073449652', 'display_name': 'Fevzi Daldal', 'orcid': 'https://orcid.org/0000-0002-2865-9574'}, 'institutions': [{'id': 'https://openalex.org/I79576946', 'display_name': 'University of Pennsylvania', 'ror': 'https://ror.org/00b30xv10', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I79576946']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Fevzi Daldal', 'raw_affiliation_strings': ['Department of Biology, University of Pennsylvania, Philadelphia, Pa. 19104 USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, University of Pennsylvania, Philadelphia, Pa. 19104 USA', 'institution_ids': ['https://openalex.org/I79576946']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5050162568', 'display_name': 'Akhil B. Vaidya', 'orcid': 'https://orcid.org/0000-0003-1063-5571'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Akhil B. Vaidya', 'raw_affiliation_strings': ['Department of Microbiology and Immunology, 2900 Queen Lane, MCP Hahnemann School of Medicine, Philadelphia, PA 19129, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Microbiology and Immunology, 2900 Queen Lane, MCP Hahnemann School of Medicine, Philadelphia, PA 19129, USA.', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 4020, 'currency': 'USD', 'value_usd': 4020, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 12.843, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 304, 'citation_normalized_percentile': {'value': 0.9825, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '33', 'issue': '4', 'first_page': '704', 'last_page': '711'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10526', 'display_name': 'HIV/AIDS drug development and treatment', 'score': 0.9985, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12369', 'display_name': 'Pneumocystis jirovecii pneumonia detection and treatment', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/atovaquone', 'display_name': 'Atovaquone', 'score': 0.9678327}], 'concepts': [{'id': 'https://openalex.org/C2779124865', 'wikidata': 'https://www.wikidata.org/wiki/Q418179', 'display_name': 'Atovaquone', 'level': 4, 'score': 0.9678327}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.82564646}, {'id': 'https://openalex.org/C148292235', 'wikidata': 'https://www.wikidata.org/wiki/Q3774486', 'display_name': 'Cytochrome b', 'level': 4, 'score': 0.7501837}, {'id': 'https://openalex.org/C28859421', 'wikidata': 'https://www.wikidata.org/wiki/Q39572', 'display_name': 'Mitochondrion', 'level': 2, 'score': 0.5380862}, {'id': 'https://openalex.org/C29311851', 'wikidata': 'https://www.wikidata.org/wiki/Q408223', 'display_name': 'Cytochrome c', 'level': 3, 'score': 0.4957758}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.48859674}, {'id': 'https://openalex.org/C2780768313', 'wikidata': 'https://www.wikidata.org/wiki/Q408068', 'display_name': 'Cytochrome', 'level': 3, 'score': 0.45998046}, {'id': 'https://openalex.org/C515207424', 'wikidata': 'https://www.wikidata.org/wiki/Q8066', 'display_name': 'Amino acid', 'level': 2, 'score': 0.43180716}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.42191023}, {'id': 'https://openalex.org/C75385678', 'wikidata': 'https://www.wikidata.org/wiki/Q4896390', 'display_name': 'Inner mitochondrial membrane', 'level': 3, 'score': 0.41414848}, {'id': 'https://openalex.org/C24586158', 'wikidata': 'https://www.wikidata.org/wiki/Q27075', 'display_name': 'Mitochondrial DNA', 'level': 3, 'score': 0.3087448}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.2513524}, {'id': 'https://openalex.org/C2778048844', 'wikidata': 'https://www.wikidata.org/wiki/Q12156', 'display_name': 'Malaria', 'level': 2, 'score': 0.2058424}, {'id': 'https://openalex.org/C2778371730', 'wikidata': 'https://www.wikidata.org/wiki/Q311383', 'display_name': 'Plasmodium falciparum', 'level': 3, 'score': 0.18342155}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.07400468}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D009285', 'descriptor_name': 'Naphthoquinones', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D010967', 'descriptor_name': 'Plasmodium yoelii', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000595', 'descriptor_name': 'Amino Acid Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000962', 'descriptor_name': 'Antimalarials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053626', 'descriptor_name': 'Atovaquone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002645', 'descriptor_name': 'Chickens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003573', 'descriptor_name': 'Cytochrome b Group', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D003573', 'descriptor_name': 'Cytochrome b Group', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004272', 'descriptor_name': 'DNA, Mitochondrial', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004272', 'descriptor_name': 'DNA, Mitochondrial', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004351', 'descriptor_name': 'Drug Resistance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004351', 'descriptor_name': 'Drug Resistance', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D004579', 'descriptor_name': 'Electron Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004579', 'descriptor_name': 'Electron Transport', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008564', 'descriptor_name': 'Membrane Potentials', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008564', 'descriptor_name': 'Membrane Potentials', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D008689', 'descriptor_name': 'Methacrylates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008928', 'descriptor_name': 'Mitochondria', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009285', 'descriptor_name': 'Naphthoquinones', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009285', 'descriptor_name': 'Naphthoquinones', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D010967', 'descriptor_name': 'Plasmodium yoelii', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010967', 'descriptor_name': 'Plasmodium yoelii', 'qualifier_ui': 'Q000472', 'qualifier_name': 'pathogenicity', 'is_major_topic': False}, {'descriptor_ui': 'D017422', 'descriptor_name': 'Sequence Analysis, DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013844', 'descriptor_name': 'Thiazoles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013844', 'descriptor_name': 'Thiazoles', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014451', 'descriptor_name': 'Ubiquinone', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014451', 'descriptor_name': 'Ubiquinone', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1046/j.1365-2958.1999.01515.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2958.1999.01515.x', 'source': {'id': 'https://openalex.org/S102549058', 'display_name': 'Molecular Microbiology', 'issn_l': '0950-382X', 'issn': ['0950-382X', '1365-2958'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10447880', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1046/j.1365-2958.1999.01515.x', 'pdf_url': 'https://onlinelibrary.wiley.com/doi/pdfdirect/10.1046/j.1365-2958.1999.01515.x', 'source': {'id': 'https://openalex.org/S102549058', 'display_name': 'Molecular Microbiology', 'issn_l': '0950-382X', 'issn': ['0950-382X', '1365-2958'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.82}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 29, 'referenced_works': ['https://openalex.org/W1146974840', 'https://openalex.org/W1491876634', 'https://openalex.org/W175983246', 'https://openalex.org/W1935016814', 'https://openalex.org/W1965834391', 'https://openalex.org/W1987070293', 'https://openalex.org/W2007561244', 'https://openalex.org/W2008957690', 'https://openalex.org/W2025605230', 'https://openalex.org/W2025781604', 'https://openalex.org/W2028482260', 'https://openalex.org/W2039254203', 'https://openalex.org/W2043384118', 'https://openalex.org/W2046194878', 'https://openalex.org/W2057943518', 'https://openalex.org/W2066306526', 'https://openalex.org/W2085832074', 'https://openalex.org/W2090657650', 'https://openalex.org/W2104243533', 'https://openalex.org/W2143685143', 'https://openalex.org/W2145412238', 'https://openalex.org/W2147775888', 'https://openalex.org/W2160088789', 'https://openalex.org/W2170621128', 'https://openalex.org/W2171201619', 'https://openalex.org/W2174691349', 'https://openalex.org/W2401007814', 'https://openalex.org/W2417170656', 'https://openalex.org/W4294253619'], 'related_works': ['https://openalex.org/W4322701378', 'https://openalex.org/W4293101415', 'https://openalex.org/W2552955488', 'https://openalex.org/W2157816346', 'https://openalex.org/W2138488546', 'https://openalex.org/W2108169668', 'https://openalex.org/W2082456955', 'https://openalex.org/W2031821124', 'https://openalex.org/W2009082036', 'https://openalex.org/W1768519799'], 'abstract_inverted_index': {'Atovaquone': [0], 'represents': [1], 'a': [2, 8, 213, 253], 'class': [3], 'of': [4, 32, 64, 72, 99, 112, 120, 132, 137, 185, 194, 206, 224, 256], 'antimicrobial': [5], 'agents': [6, 245], 'with': [7, 102, 151, 158, 180], 'broad-spectrum': [9], 'activity': [10], 'against': [11, 79], 'various': [12], 'parasitic': [13], 'infections,': [14], 'including': [15], 'malaria,': [16], 'toxoplasmosis': [17], 'and': [18, 37, 156, 222, 233], 'Pneumocystis': [19], 'pneumonia.': [20], 'In': [21, 42], 'malaria': [22, 93], 'parasites,': [23], 'atovaquone': [24, 73, 191], 'inhibits': [25], 'mitochondrial': [26, 39, 59, 113], 'electron': [27, 121], 'transport': [28], 'at': [29], 'the': [30, 33, 57, 65, 69, 129, 138, 165, 171, 195, 201, 207, 225], 'level': [31], 'cytochrome': [34, 141, 209, 249], 'bc1': [35, 210, 250], 'complex': [36, 211], 'collapses': [38], 'membrane': [40, 114], 'potential.': [41], 'addition,': [43], 'this': [44], 'drug': [45], 'is': [46], 'unique': [47], 'in': [48, 76, 170, 216, 220, 243, 252], 'being': [49], 'selectively': [50, 247], 'toxic': [51], 'to': [52, 109, 128], 'parasite': [53, 94], 'mitochondria': [54], 'without': [55], 'affecting': [56], 'host': [58], 'functions.': [60], 'A': [61], 'better': [62], 'understanding': [63], 'structural': [66, 238], 'basis': [67], 'for': [68], 'selective': [70, 235], 'toxicity': [71], 'could': [74], 'help': [75], 'designing': [77, 244], 'drugs': [78], 'infections': [80], 'caused': [81], 'by': [82, 96], 'mitochondria-containing': [83], 'parasites.': [84], 'To': [85], 'that': [86, 246], 'end,': [87], 'we': [88], 'derived': [89, 174], 'nine': [90, 172], 'independent': [91], 'atovaquone-resistant': [92], 'lines': [95], 'suboptimal': [97], 'treatment': [98], 'mice': [100], 'infected': [101], 'Plasmodium': [103], 'yoelii;': [104], 'these': [105, 145], 'mutants': [106, 124, 146, 175], 'exhibited': [107], 'resistance': [108], 'atovaquone-mediated': [110], 'collapse': [111], 'potential': [115], 'as': [116, 118], 'well': [117], 'inhibition': [119], 'transport.': [122], 'The': [123], 'were': [125], 'also': [126], 'resistant': [127], 'synergistic': [130], 'effects': [131], 'atovaquone/': [133], 'proguanil': [134], 'combination.': [135], 'Sequencing': [136], 'mitochondrially': [139], 'encoded': [140], 'b': [142], 'gene': [143], 'placed': [144], 'into': [147], 'four': [148], 'categories,': [149], 'three': [150], 'single': [152], 'amino': [153, 161, 197, 226], 'acid': [154, 162, 198, 227], 'changes': [155, 168], 'one': [157], 'two': [159], 'adjacent': [160], 'changes.': [163], 'Of': [164], '12': [166], 'nucleotide': [167], 'seen': [169], 'independently': [173], '11': [176], 'replaced': [177], 'A:T': [178], 'basepairs': [179], 'G:C': [181], 'basepairs,': [182], 'possibly': [183], 'because': [184], 'reactive': [186], 'oxygen': [187], 'species': [188], 'resulting': [189], 'from': [190], 'treatment.': [192], 'Visualization': [193], 'resistance-conferring': [196], 'positions': [199], 'on': [200], 'recently': [202], 'solved': [203], 'crystal': [204], 'structure': [205], 'vertebrate': [208], 'revealed': [212], 'discrete': [214], 'cavity': [215], 'which': [217], 'subtle': [218], 'variations': [219], 'hydrophobicity': [221], 'volume': [223], 'side-chains': [228], 'may': [229, 240], 'determine': [230], 'atovaquone-binding': [231], 'affinity,': [232], 'thereby': [234], 'toxicity.': [236], 'These': [237], 'insights': [239], 'prove': [241], 'useful': [242], 'affect': [248], 'functions': [251], 'wide': [254], 'range': [255], 'eukaryotic': [257], 'pathogens.': [258]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2138488546', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 7}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 15}, {'year': 2017, 'cited_by_count': 11}, {'year': 2016, 'cited_by_count': 14}, {'year': 2015, 'cited_by_count': 16}, {'year': 2014, 'cited_by_count': 14}, {'year': 2013, 'cited_by_count': 21}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2024-12-20T08:55:12.012780', 'created_date': '2016-06-24'}