Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2138133724', 'doi': 'https://doi.org/10.1242/jcs.079095', 'title': 'Differential palmitoylation regulates intracellular patterning of SNAP25', 'display_name': 'Differential palmitoylation regulates intracellular patterning of SNAP25', 'publication_year': 2011, 'publication_date': '2011-03-24', 'ids': {'openalex': 'https://openalex.org/W2138133724', 'doi': 'https://doi.org/10.1242/jcs.079095', 'mag': '2138133724', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21429935', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/3065388'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/jcs.079095', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S5677253', 'display_name': 'Journal of Cell Science', 'issn_l': '0021-9533', 'issn': ['0021-9533', '1477-9137'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1242/jcs.079095', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5009712373', 'display_name': 'Jennifer Greaves', 'orcid': 'https://orcid.org/0000-0001-8445-789X'}, 'institutions': [{'id': 'https://openalex.org/I98677209', 'display_name': 'University of Edinburgh', 'ror': 'https://ror.org/01nrxwf90', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I98677209']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Jennifer Greaves', 'raw_affiliation_strings': ['Centre for Integrative Physiology, School of Biomedical Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, UK'], 'affiliations': [{'raw_affiliation_string': 'Centre for Integrative Physiology, School of Biomedical Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, UK', 'institution_ids': ['https://openalex.org/I98677209']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5073204685', 'display_name': 'Luke Chamberlain', 'orcid': 'https://orcid.org/0000-0002-8701-4995'}, 'institutions': [{'id': 'https://openalex.org/I98677209', 'display_name': 'University of Edinburgh', 'ror': 'https://ror.org/01nrxwf90', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I98677209']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Luke H. Chamberlain', 'raw_affiliation_strings': ['Centre for Integrative Physiology, School of Biomedical Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, UK'], 'affiliations': [{'raw_affiliation_string': 'Centre for Integrative Physiology, School of Biomedical Sciences, Hugh Robson Building, University of Edinburgh, Edinburgh EH8 9XD, UK', 'institution_ids': ['https://openalex.org/I98677209']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 2.335, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 52, 'citation_normalized_percentile': {'value': 0.999878, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '124', 'issue': '8', 'first_page': '1351', 'last_page': '1360'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10617', 'display_name': 'Cellular transport and secretion', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10691', 'display_name': 'Retinal Development and Disorders', 'score': 0.9948, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10407', 'display_name': 'Lipid Membrane Structure and Behavior', 'score': 0.9909, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/palmitoylation', 'display_name': 'Palmitoylation', 'score': 0.9600351}, {'id': 'https://openalex.org/keywords/snap25', 'display_name': 'SNAP25', 'score': 0.8874501}, {'id': 'https://openalex.org/keywords/gap-43-protein', 'display_name': 'Gap-43 protein', 'score': 0.63921523}], 'concepts': [{'id': 'https://openalex.org/C146727910', 'wikidata': 'https://www.wikidata.org/wiki/Q501620', 'display_name': 'Palmitoylation', 'level': 4, 'score': 0.9600351}, {'id': 'https://openalex.org/C134499376', 'wikidata': 'https://www.wikidata.org/wiki/Q14897641', 'display_name': 'SNAP25', 'level': 5, 'score': 0.8874501}, {'id': 'https://openalex.org/C102747710', 'wikidata': 'https://www.wikidata.org/wiki/Q824237', 'display_name': 'Endosome', 'level': 3, 'score': 0.7548585}, {'id': 'https://openalex.org/C90770895', 'wikidata': 'https://www.wikidata.org/wiki/Q14906268', 'display_name': 'Gap-43 protein', 'level': 3, 'score': 0.63921523}, {'id': 'https://openalex.org/C79879829', 'wikidata': 'https://www.wikidata.org/wiki/Q5571762', 'display_name': 'Intracellular', 'level': 2, 'score': 0.63816696}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.59271747}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.5644033}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.37841672}, {'id': 'https://openalex.org/C2779201268', 'wikidata': 'https://www.wikidata.org/wiki/Q186474', 'display_name': 'Cysteine', 'level': 3, 'score': 0.35668713}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.34003496}, {'id': 'https://openalex.org/C130316041', 'wikidata': 'https://www.wikidata.org/wiki/Q189206', 'display_name': 'Vesicle', 'level': 3, 'score': 0.27817768}, {'id': 'https://openalex.org/C41625074', 'wikidata': 'https://www.wikidata.org/wiki/Q176088', 'display_name': 'Membrane', 'level': 2, 'score': 0.15053469}, {'id': 'https://openalex.org/C148785051', 'wikidata': 'https://www.wikidata.org/wiki/Q671136', 'display_name': 'Synaptic vesicle', 'level': 4, 'score': 0.13711315}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D042541', 'descriptor_name': 'Intracellular Space', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D050825', 'descriptor_name': 'Synaptosomal-Associated Protein 25', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002462', 'descriptor_name': 'Cell Membrane', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011992', 'descriptor_name': 'Endosomes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D011992', 'descriptor_name': 'Endosomes', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011992', 'descriptor_name': 'Endosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042541', 'descriptor_name': 'Intracellular Space', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D042541', 'descriptor_name': 'Intracellular Space', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D054878', 'descriptor_name': 'Lipoylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016716', 'descriptor_name': 'PC12 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021381', 'descriptor_name': 'Protein Transport', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050825', 'descriptor_name': 'Synaptosomal-Associated Protein 25', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050825', 'descriptor_name': 'Synaptosomal-Associated Protein 25', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D021601', 'descriptor_name': 'trans-Golgi Network', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D021601', 'descriptor_name': 'trans-Golgi Network', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D021601', 'descriptor_name': 'trans-Golgi Network', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/jcs.079095', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S5677253', 'display_name': 'Journal of Cell Science', 'issn_l': '0021-9533', 'issn': ['0021-9533', '1477-9137'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065388', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc3065388', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21429935', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1242/jcs.079095', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S5677253', 'display_name': 'Journal of Cell Science', 'issn_l': '0021-9533', 'issn': ['0021-9533', '1477-9137'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311847', 'host_organization_name': 'The Company of Biologists', 'host_organization_lineage': ['https://openalex.org/P4310311847'], 'host_organization_lineage_names': ['The Company of Biologists'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 39, 'referenced_works': ['https://openalex.org/W1502795635', 'https://openalex.org/W1603362495', 'https://openalex.org/W1649931880', 'https://openalex.org/W1966278622', 'https://openalex.org/W1971016259', 'https://openalex.org/W1986827801', 'https://openalex.org/W1990524685', 'https://openalex.org/W1991402029', 'https://openalex.org/W1992186441', 'https://openalex.org/W1998865212', 'https://openalex.org/W1998917031', 'https://openalex.org/W2000302106', 'https://openalex.org/W2002834476', 'https://openalex.org/W2007982098', 'https://openalex.org/W2020069648', 'https://openalex.org/W2023361978', 'https://openalex.org/W2027327211', 'https://openalex.org/W2027775552', 'https://openalex.org/W2034292153', 'https://openalex.org/W2034512365', 'https://openalex.org/W2042011439', 'https://openalex.org/W2043768757', 'https://openalex.org/W2048559110', 'https://openalex.org/W2057518135', 'https://openalex.org/W2069990903', 'https://openalex.org/W2088402888', 'https://openalex.org/W2098301486', 'https://openalex.org/W2098635239', 'https://openalex.org/W2105722661', 'https://openalex.org/W2124781523', 'https://openalex.org/W2124792702', 'https://openalex.org/W2126456979', 'https://openalex.org/W2126889712', 'https://openalex.org/W2128008102', 'https://openalex.org/W2134554383', 'https://openalex.org/W2139472455', 'https://openalex.org/W2145075118', 'https://openalex.org/W2151862262', 'https://openalex.org/W2182059649'], 'related_works': ['https://openalex.org/W4383818699', 'https://openalex.org/W3180324226', 'https://openalex.org/W2891777780', 'https://openalex.org/W2624654193', 'https://openalex.org/W2489528588', 'https://openalex.org/W2138133724', 'https://openalex.org/W2133518897', 'https://openalex.org/W2124781523', 'https://openalex.org/W2046538616', 'https://openalex.org/W1987216981'], 'abstract_inverted_index': {'SNAP25': [0, 38, 83, 99, 190], 'regulates': [1], 'membrane': [2, 8, 42, 205], 'fusion': [3], 'events': [4], 'at': [5, 84, 202], 'the': [6, 11, 19, 28, 58, 67, 80, 85, 105, 111, 120, 132, 137, 141, 146, 154, 186, 195, 203, 218], 'plasma': [7, 204], 'and': [9, 14, 27, 44, 73, 87, 118, 134, 158, 206, 208], 'in': [10, 125, 144, 153, 172], 'endosomal': [12], 'system,': [13], 'a': [15, 40, 47, 98, 177, 214], 'functional': [16], 'pool': [17], 'of': [18, 46, 49, 71, 82, 122, 140, 149, 156, 189, 198, 222], 'protein': [20, 201], 'is': [21, 39, 191], 'delivered': [22], 'to': [23, 104, 193, 216], 'recycling': [24], 'endosomes': [25], '(REs)': [26], 'trans': [29], 'Golgi': [30], 'network': [31], '(TGN)': [32], 'through': [33], 'an': [34], 'ARF6-dependent': [35], 'cycling': [36], 'pathway.': [37], 'peripheral': [41], 'protein,': [43], 'palmitoylation': [45, 64, 77, 164, 211], 'cluster': [48], 'four': [50], 'cysteine': [51, 123], 'residues': [52, 124], 'mediates': [53], 'its': [54, 129], 'stable': [55], 'association': [56, 130], 'with': [57, 131, 162], 'membrane.': [59], 'Here,': [60], 'we': [61], 'report': [62], 'that': [63, 74, 169, 185, 209], 'also': [65], 'determines': [66], 'precise': [68, 219], 'intracellular': [69, 113, 147, 181, 220], 'distribution': [70, 114, 148], 'SNAP25,': [72, 117], 'mutating': [75], 'single': [76], 'sites': [78], 'enhances': [79], 'amount': [81], 'RE': [86, 133], 'TGN.': [88], 'The': [89], 'farnesylated': [90], 'CAAX': [91], 'motif': [92], 'from': [93], 'Hras': [94, 159], 'was': [95], 'ligated': [96], 'onto': [97], 'mutant': [100], 'truncated': [101], 'immediately': [102], 'distal': [103], 'cysteine-rich': [106, 142, 187], 'domain.': [107], 'This': [108], 'construct': [109, 127], 'displayed': [110], 'same': [112], 'as': [115, 213], 'full-length': [116], 'decreasing': [119], 'number': [121], 'this': [126, 199], 'increased': [128], 'TGN,': [135], 'confirming': [136], 'dominant': [138], 'role': [139], 'domain': [143, 188], 'directing': [145], 'SNAP25.': [150, 223], 'Marked': [151], 'differences': [152, 171], 'localisations': [155], 'SNAP25-CAAX': [157], 'constructs,': [160], 'each': [161], 'two': [163], 'sites,': [165], 'were': [166], 'observed,': [167], 'showing': [168], 'subtle': [170], 'palmitoylated': [173], 'sequences': [174], 'can': [175], 'have': [176], 'major': [178], 'impact': [179], 'upon': [180], 'targeting.': [182], 'We': [183], 'propose': [184], 'designed': [192], 'facilitate': [194], 'dual': [196], 'function': [197], 'SNARE': [200], 'endosomes,': [207], 'dynamic': [210], 'acts': [212], 'mechanism': [215], 'regulate': [217], 'patterning': [221]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2138133724', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 2}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-07T16:43:05.964214', 'created_date': '2016-06-24'}