Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2138100316', 'doi': 'https://doi.org/10.1073/pnas.94.8.3893', 'title': 'Cytosine methylation determines hot spots of DNA damage in the human <i>P</i> 53 gene', 'display_name': 'Cytosine methylation determines hot spots of DNA damage in the human <i>P</i> 53 gene', 'publication_year': 1997, 'publication_date': '1997-04-15', 'ids': {'openalex': 'https://openalex.org/W2138100316', 'doi': 'https://doi.org/10.1073/pnas.94.8.3893', 'mag': '2138100316', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/9108075', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/20538'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.94.8.3893', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1073/pnas.94.8.3893', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5077112114', 'display_name': 'Mikhail F. Denissenko', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210110459', 'display_name': 'City of Hope', 'ror': 'https://ror.org/01z1vct10', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528', 'https://openalex.org/I4210110459']}, {'id': 'https://openalex.org/I4387156432', 'display_name': 'Beckman Research Institute', 'ror': 'https://ror.org/05fazth07', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I1301076528', 'https://openalex.org/I4387156432']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mikhail F. Denissenko', 'raw_affiliation_strings': ['Department of Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010; and University of Texas, M.D. Anderson Cancer Center, Smithville, TX 78957'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010; and University of Texas, M.D. Anderson Cancer Center, Smithville, TX 78957', 'institution_ids': ['https://openalex.org/I4210110459', 'https://openalex.org/I4387156432']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050847709', 'display_name': 'James X. Chen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210110459', 'display_name': 'City of Hope', 'ror': 'https://ror.org/01z1vct10', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528', 'https://openalex.org/I4210110459']}, {'id': 'https://openalex.org/I4387156432', 'display_name': 'Beckman Research Institute', 'ror': 'https://ror.org/05fazth07', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I1301076528', 'https://openalex.org/I4387156432']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James X. Chen', 'raw_affiliation_strings': ['Department of Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010; and University of Texas, M.D. Anderson Cancer Center, Smithville, TX 78957'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010; and University of Texas, M.D. Anderson Cancer Center, Smithville, TX 78957', 'institution_ids': ['https://openalex.org/I4210110459', 'https://openalex.org/I4387156432']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049537474', 'display_name': 'Moon‐shong Tang', 'orcid': 'https://orcid.org/0000-0001-7898-6322'}, 'institutions': [{'id': 'https://openalex.org/I4210110459', 'display_name': 'City of Hope', 'ror': 'https://ror.org/01z1vct10', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528', 'https://openalex.org/I4210110459']}, {'id': 'https://openalex.org/I4387156432', 'display_name': 'Beckman Research Institute', 'ror': 'https://ror.org/05fazth07', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I1301076528', 'https://openalex.org/I4387156432']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Moon-shong Tang', 'raw_affiliation_strings': ['Department of Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010; and University of Texas, M.D. Anderson Cancer Center, Smithville, TX 78957'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010; and University of Texas, M.D. Anderson Cancer Center, Smithville, TX 78957', 'institution_ids': ['https://openalex.org/I4210110459', 'https://openalex.org/I4387156432']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5048312997', 'display_name': 'Gerd P. Pfeifer', 'orcid': 'https://orcid.org/0000-0002-5080-9604'}, 'institutions': [{'id': 'https://openalex.org/I4210110459', 'display_name': 'City of Hope', 'ror': 'https://ror.org/01z1vct10', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1301076528', 'https://openalex.org/I4210110459']}, {'id': 'https://openalex.org/I4387156432', 'display_name': 'Beckman Research Institute', 'ror': 'https://ror.org/05fazth07', 'country_code': None, 'type': 'facility', 'lineage': ['https://openalex.org/I1301076528', 'https://openalex.org/I4387156432']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gerd P. Pfeifer', 'raw_affiliation_strings': ['Department of Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010; and University of Texas, M.D. Anderson Cancer Center, Smithville, TX 78957'], 'affiliations': [{'raw_affiliation_string': 'Department of Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010; and University of Texas, M.D. Anderson Cancer Center, Smithville, TX 78957', 'institution_ids': ['https://openalex.org/I4210110459', 'https://openalex.org/I4387156432']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 7.643, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 335, 'citation_normalized_percentile': {'value': 0.999969, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '94', 'issue': '8', 'first_page': '3893', 'last_page': '3898'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.9906, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13157', 'display_name': 'Cancer-related gene regulation', 'score': 0.9902, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/cpg-site', 'display_name': 'CpG site', 'score': 0.76595175}], 'concepts': [{'id': 'https://openalex.org/C140173407', 'wikidata': 'https://www.wikidata.org/wiki/Q1138358', 'display_name': 'CpG site', 'level': 5, 'score': 0.76595175}, {'id': 'https://openalex.org/C190727270', 'wikidata': 'https://www.wikidata.org/wiki/Q874745', 'display_name': 'DNA methylation', 'level': 4, 'score': 0.6542804}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.62038827}, {'id': 'https://openalex.org/C33288867', 'wikidata': 'https://www.wikidata.org/wiki/Q518328', 'display_name': 'Methylation', 'level': 3, 'score': 0.5779669}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.57248193}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.519985}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.50618213}, {'id': 'https://openalex.org/C37080517', 'wikidata': 'https://www.wikidata.org/wiki/Q18353747', 'display_name': 'Epigenetics of physical exercise', 'level': 5, 'score': 0.47247168}, {'id': 'https://openalex.org/C129312508', 'wikidata': 'https://www.wikidata.org/wiki/Q133686', 'display_name': 'Oligonucleotide', 'level': 3, 'score': 0.46820384}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.39817083}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.39133236}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.30956972}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.20958212}], 'mesh': [{'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D004249', 'descriptor_name': 'DNA Damage', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D016159', 'descriptor_name': 'Tumor Suppressor Protein p53', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003596', 'descriptor_name': 'Cytosine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019175', 'descriptor_name': 'DNA Methylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009154', 'descriptor_name': 'Mutation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.94.8.3893', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc20538', 'pdf_url': 'https://europepmc.org/articles/pmc20538?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC20538', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/9108075', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1073/pnas.94.8.3893', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S125754415', 'display_name': 'Proceedings of the National Academy of Sciences', 'issn_l': '0027-8424', 'issn': ['0027-8424', '1091-6490'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320052', 'host_organization_name': 'National Academy of Sciences', 'host_organization_lineage': ['https://openalex.org/P4310320052'], 'host_organization_lineage_names': ['National Academy of Sciences'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.68, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 60, 'referenced_works': ['https://openalex.org/W1506883380', 'https://openalex.org/W1509148122', 'https://openalex.org/W1520465138', 'https://openalex.org/W1541911998', 'https://openalex.org/W1552426876', 'https://openalex.org/W158760893', 'https://openalex.org/W1598239887', 'https://openalex.org/W1600706591', 'https://openalex.org/W1892740436', 'https://openalex.org/W1966497102', 'https://openalex.org/W1976056213', 'https://openalex.org/W1976056964', 'https://openalex.org/W1977706798', 'https://openalex.org/W1983832776', 'https://openalex.org/W1989145783', 'https://openalex.org/W1994928133', 'https://openalex.org/W2000457368', 'https://openalex.org/W2001742280', 'https://openalex.org/W2011331080', 'https://openalex.org/W2012353929', 'https://openalex.org/W2013255015', 'https://openalex.org/W2016799258', 'https://openalex.org/W2017682851', 'https://openalex.org/W2018635472', 'https://openalex.org/W2027776416', 'https://openalex.org/W2029874395', 'https://openalex.org/W2032506756', 'https://openalex.org/W2033355069', 'https://openalex.org/W2033868456', 'https://openalex.org/W2036523030', 'https://openalex.org/W2039067014', 'https://openalex.org/W2040260715', 'https://openalex.org/W2040626587', 'https://openalex.org/W2040685858', 'https://openalex.org/W2051191795', 'https://openalex.org/W2051632678', 'https://openalex.org/W2056103475', 'https://openalex.org/W2057805027', 'https://openalex.org/W2066190225', 'https://openalex.org/W2071046988', 'https://openalex.org/W2076467483', 'https://openalex.org/W2086096842', 'https://openalex.org/W2090450153', 'https://openalex.org/W2102377790', 'https://openalex.org/W2113954582', 'https://openalex.org/W2126943822', 'https://openalex.org/W2135718122', 'https://openalex.org/W2139046279', 'https://openalex.org/W2139620481', 'https://openalex.org/W2146495559', 'https://openalex.org/W2168342276', 'https://openalex.org/W2197237365', 'https://openalex.org/W2246556406', 'https://openalex.org/W2398025271', 'https://openalex.org/W2468478394', 'https://openalex.org/W3005341051', 'https://openalex.org/W4235120173', 'https://openalex.org/W4238597020', 'https://openalex.org/W4242369649', 'https://openalex.org/W600145501'], 'related_works': ['https://openalex.org/W2944524138', 'https://openalex.org/W2921336251', 'https://openalex.org/W2902329290', 'https://openalex.org/W2169344098', 'https://openalex.org/W2151182744', 'https://openalex.org/W2139872319', 'https://openalex.org/W2123238153', 'https://openalex.org/W2107880877', 'https://openalex.org/W2052355316', 'https://openalex.org/W2046964473'], 'abstract_inverted_index': {'In': [0], 'the': [1, 23, 32, 71, 98, 106, 137, 142, 187, 234, 237], 'P53': [2, 34, 113], 'tumor': [3], 'suppressor': [4], 'gene,': [5], 'a': [6, 221], 'remarkably': [7], 'large': [8], 'number': [9], 'of': [10, 25, 55, 63, 87, 100, 172, 186, 239], 'somatic': [11], 'mutations': [12], 'are': [13, 70, 166, 246], 'found': [14], 'at': [15, 58, 129, 178, 247], 'methylated': [16, 208], 'CpG': [17, 61, 130, 179, 209], 'dinucleotides.': [18], 'We': [19], 'have': [20, 104], 'previously': [21], 'mapped': [22, 105], 'distribution': [24], '(+/-)': [26], 'anti-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy': [27], '-7,8,9,10-tetrahydrobenzo[a]pyrene': [28], '(BPDE)': [29], 'adducts': [30, 56, 107], 'along': [31], 'human': [33, 196, 244], 'gene': [35, 189], '[Denissenko,': [36], 'M.': [37], 'F.,': [38], 'Pao,': [39], 'A.,': [40], 'Tang,': [41], 'M.-s.': [42], '&': [43], 'Pfeifer,': [44], 'G.': [45], 'P.': [46], '(1996)': [47], 'Science': [48], '274,': [49], '430-432].': [50], 'Strong': [51], 'and': [52, 67, 141, 199], 'selective': [53], 'formation': [54, 177], 'occurred': [57], 'guanines': [59], 'in': [60, 76, 84, 108, 123, 160, 211, 243], 'sequences': [62, 131, 185], 'codons': [64], '157,': [65], '248,': [66], '273,': [68], 'which': [69, 154], 'major': [72], 'mutational': [73, 240], 'hot': [74, 150, 241], 'spots': [75, 151, 242], 'lung': [77], 'cancer.': [78], 'Chromatin': [79], 'structure': [80], 'was': [81, 119, 144, 181], 'not': [82], 'involved': [83], 'preferential': [85, 222], 'modification': [86], 'these': [88], 'sites': [89, 180], 'by': [90, 136], 'BPDE.': [91], 'To': [92], 'investigate': [93], 'other': [94], 'possible': [95], 'mechanisms': [96], 'underlying': [97], 'selectivity': [99], 'BPDE': [101, 175], 'binding,': [102], 'we': [103], 'plasmid': [109], 'DNA': [110, 143, 162], 'containing': [111], 'genomic': [112, 124, 161], 'sequences.': [114], 'The': [115, 228], 'adduct': [116, 149, 176], 'profile': [117], 'obtained': [118], 'different': [120], 'from': [121, 191], 'that': [122, 207, 236], 'DNA.': [125], 'However,': [126], 'when': [127], 'cytosines': [128], 'were': [132, 152, 155], 'converted': [133], 'to': [134, 157, 213], '5-methylcytosines': [135], 'CpG-specific': [138], 'methylase': [139], 'SssI': [140], 'subsequently': [145], 'treated': [146], 'with': [147, 184], 'BPDE,': [148], 'created': [153], 'similar': [156], 'those': [158], 'seen': [159], 'where': [163], 'all': [164], 'CpGs': [165], 'methylated.': [167], 'A': [168], 'strong': [169], 'positive': [170], 'effect': [171], '5-methylcytosine': [173], 'on': [174], 'also': [182], 'documented': [183], 'PGK1': [188], 'derived': [190], 'an': [192, 215], 'active': [193], 'or': [194], 'inactive': [195], 'X': [197], 'chromosome': [198], 'having': [200], 'differential': [201], 'methylation': [202], 'patterns.': [203], 'These': [204], 'results': [205], 'show': [206], 'dinucleotides,': [210], 'addition': [212], 'being': [214], 'endogenous': [216], 'promutagenic': [217], 'factor,': [218], 'may': [219], 'represent': [220], 'target': [223], 'for': [224], 'exogenous': [225], 'chemical': [226], 'carcinogens.': [227], 'data': [229], 'open': [230], 'new': [231], 'avenues': [232], 'concerning': [233], 'reasons': [235], 'majority': [238], 'genes': [245], 'CpGs.': [248]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2138100316', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 13}, {'year': 2016, 'cited_by_count': 8}, {'year': 2015, 'cited_by_count': 12}, {'year': 2014, 'cited_by_count': 9}, {'year': 2013, 'cited_by_count': 9}, {'year': 2012, 'cited_by_count': 15}], 'updated_date': '2024-12-15T09:43:48.295115', 'created_date': '2016-06-24'}