Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2138078973', 'doi': 'https://doi.org/10.1002/path.3026', 'title': 'Microtubule‐binding protein CLIP‐170 is a mediator of paclitaxel sensitivity', 'display_name': 'Microtubule‐binding protein CLIP‐170 is a mediator of paclitaxel sensitivity', 'publication_year': 2012, 'publication_date': '2012-01-17', 'ids': {'openalex': 'https://openalex.org/W2138078973', 'doi': 'https://doi.org/10.1002/path.3026', 'mag': '2138078973', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21989536'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/path.3026', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4394736614', 'display_name': 'The Journal of Pathology', 'issn_l': '0022-3417', 'issn': ['0022-3417', '1096-9896'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5065615188', 'display_name': 'Xiaodong Sun', 'orcid': 'https://orcid.org/0000-0001-7775-2823'}, 'institutions': [{'id': 'https://openalex.org/I205237279', 'display_name': 'Nankai University', 'ror': 'https://ror.org/01y1kjr75', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I205237279']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaodong Sun', 'raw_affiliation_strings': ['Department of Genetics and Cell Biology, Tianjin Key Laboratory of Protein Science, College of Life Sciences, Nankai University, Tianjin 300071, China.'], 'affiliations': [{'raw_affiliation_string': 'Department of Genetics and Cell Biology, Tianjin Key Laboratory of Protein Science, College of Life Sciences, Nankai University, Tianjin 300071, China.', 'institution_ids': ['https://openalex.org/I205237279']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058127847', 'display_name': 'Dengwen Li', 'orcid': 'https://orcid.org/0000-0002-4573-7191'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Dengwen Li', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030343111', 'display_name': 'Yunfan Yang', 'orcid': 'https://orcid.org/0000-0002-5266-7208'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yunfan Yang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5055908487', 'display_name': 'Yuan Ren', 'orcid': 'https://orcid.org/0000-0001-7155-7664'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yuan Ren', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086134325', 'display_name': 'Jingyu Li', 'orcid': 'https://orcid.org/0000-0002-2511-4157'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jingyu Li', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036400535', 'display_name': 'Zaizhu Wang', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Zaizhu Wang', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101805494', 'display_name': 'Bin Dong', 'orcid': 'https://orcid.org/0000-0002-0349-446X'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Bin Dong', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100343883', 'display_name': 'Min Liu', 'orcid': 'https://orcid.org/0000-0002-1626-7100'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Min Liu', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5022169204', 'display_name': 'Jun Zhou', 'orcid': 'https://orcid.org/0000-0001-7858-8260'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jun Zhou', 'raw_affiliation_strings': [], 'affiliations': []}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.431, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 50, 'citation_normalized_percentile': {'value': 0.892796, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '226', 'issue': '4', 'first_page': '666', 'last_page': '673'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10492', 'display_name': 'Regulation and Function of Microtubules in Cell Division', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10492', 'display_name': 'Regulation and Function of Microtubules in Cell Division', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10583', 'display_name': 'The p53 Signaling Network in Cancer Research', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11752', 'display_name': 'Chemotherapy-Induced Peripheral Neuropathy in Cancer Treatment', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/microtubules', 'display_name': 'Microtubules', 'score': 0.52265}, {'id': 'https://openalex.org/keywords/microtubule-targeting-agents', 'display_name': 'Microtubule-Targeting Agents', 'score': 0.508069}, {'id': 'https://openalex.org/keywords/microtubule-polymerization', 'display_name': 'Microtubule polymerization', 'score': 0.48771796}, {'id': 'https://openalex.org/keywords/mediator', 'display_name': 'Mediator', 'score': 0.41314995}], 'concepts': [{'id': 'https://openalex.org/C2777292972', 'wikidata': 'https://www.wikidata.org/wiki/Q423762', 'display_name': 'Paclitaxel', 'level': 3, 'score': 0.9427875}, {'id': 'https://openalex.org/C20418707', 'wikidata': 'https://www.wikidata.org/wiki/Q189933', 'display_name': 'Microtubule', 'level': 2, 'score': 0.8259884}, {'id': 'https://openalex.org/C93304396', 'wikidata': 'https://www.wikidata.org/wiki/Q14763008', 'display_name': 'Mitosis', 'level': 2, 'score': 0.6024495}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.50983566}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.50564766}, {'id': 'https://openalex.org/C2909009945', 'wikidata': 'https://www.wikidata.org/wiki/Q189933', 'display_name': 'Microtubule polymerization', 'level': 4, 'score': 0.48771796}, {'id': 'https://openalex.org/C84425145', 'wikidata': 'https://www.wikidata.org/wiki/Q422492', 'display_name': 'Tubulin', 'level': 3, 'score': 0.46798038}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.45692042}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.44793522}, {'id': 'https://openalex.org/C2107291', 'wikidata': 'https://www.wikidata.org/wiki/Q14886885', 'display_name': 'Mediator', 'level': 2, 'score': 0.41314995}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.41302347}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.40086207}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.39560062}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.15502685}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.06727049}], 'mesh': [{'descriptor_ui': 'D000972', 'descriptor_name': 'Antineoplastic Agents, Phytogenic', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D008869', 'descriptor_name': 'Microtubule-Associated Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008870', 'descriptor_name': 'Microtubules', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D017239', 'descriptor_name': 'Paclitaxel', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000972', 'descriptor_name': 'Antineoplastic Agents, Phytogenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000601', 'qualifier_name': 'surgery', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004354', 'descriptor_name': 'Drug Screening Assays, Antitumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008869', 'descriptor_name': 'Microtubule-Associated Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008870', 'descriptor_name': 'Microtubules', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008870', 'descriptor_name': 'Microtubules', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020360', 'descriptor_name': 'Neoadjuvant Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017239', 'descriptor_name': 'Paclitaxel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/path.3026', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4394736614', 'display_name': 'The Journal of Pathology', 'issn_l': '0022-3417', 'issn': ['0022-3417', '1096-9896'], 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21989536', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.7}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 24, 'referenced_works': ['https://openalex.org/W114421267', 'https://openalex.org/W1495332006', 'https://openalex.org/W1566786752', 'https://openalex.org/W1971579914', 'https://openalex.org/W1985034396', 'https://openalex.org/W2005312602', 'https://openalex.org/W2020906481', 'https://openalex.org/W2021135236', 'https://openalex.org/W2027542963', 'https://openalex.org/W2037834300', 'https://openalex.org/W2040090588', 'https://openalex.org/W2049135828', 'https://openalex.org/W2055397209', 'https://openalex.org/W2081289502', 'https://openalex.org/W2091735806', 'https://openalex.org/W2106787323', 'https://openalex.org/W2106890990', 'https://openalex.org/W2113080446', 'https://openalex.org/W2119545286', 'https://openalex.org/W2120863112', 'https://openalex.org/W2140082316', 'https://openalex.org/W2142418178', 'https://openalex.org/W2154094988', 'https://openalex.org/W2154968967'], 'related_works': ['https://openalex.org/W3163690654', 'https://openalex.org/W2901583425', 'https://openalex.org/W2528453622', 'https://openalex.org/W2415662583', 'https://openalex.org/W2405887049', 'https://openalex.org/W2163867568', 'https://openalex.org/W2093374415', 'https://openalex.org/W2024145976', 'https://openalex.org/W2020008420', 'https://openalex.org/W1901412126'], 'abstract_inverted_index': {'Abstract': [0], 'CLIP‐170': [1, 22, 44, 59, 85, 118, 131, 145], 'is': [2, 23], 'a': [3, 24, 153], 'microtubule‐binding': [4], 'protein': [5], 'and': [6, 79, 98, 110, 164], 'participates': [7], 'in': [8, 34, 46, 61, 102, 149], 'diverse': [9], 'microtubule‐associated': [10], 'cellular': [11], 'activities': [12], 'by': [13, 167], 'regulating': [14], 'microtubule': [15, 107, 139], 'dynamics.': [16], 'Here': [17], 'we': [18, 114], 'provide': [19], 'evidence': [20], 'that': [21, 43, 84, 117, 130, 144], 'mediator': [25], 'of': [26, 29, 64, 72, 89, 135, 161], 'the': [27, 30, 69, 87, 133], 'sensitivity': [28, 54, 148], 'anti‐microtubule': [31], 'drug': [32], 'paclitaxel': [33, 90, 120, 136, 147], 'breast': [35, 47, 65, 103, 150], 'cancer.': [36], 'In': [37, 57, 124], 'vitro': [38, 125], 'cell': [39, 49, 93], 'proliferation': [40], 'assays': [41], 'reveal': [42, 83], 'expression': [45, 60], 'cancer': [48, 66, 104, 151], 'lines': [50], 'correlates': [51, 67], 'with': [52, 68], 'their': [53], 'to': [55, 74, 91, 99, 122, 137], 'paclitaxel.': [56], 'addition,': [58], 'clinical': [62], 'samples': [63], 'pathological': [70], 'response': [71], 'tumours': [73], 'paclitaxel‐containing': [75], 'chemotherapy.': [76], 'Mitotic': [77], 'index': [78], 'caspase‐3': [80], 'activity': [81, 134], 'analyses': [82], 'increases': [86], 'abilities': [88], 'block': [92], 'cycle': [94], 'progression': [95], 'at': [96], 'mitosis': [97], 'induce': [100], 'apoptosis': [101], 'cells.': [105], 'By': [106], 'sedimentation': [108], 'assay': [109, 128], 'binding': [111, 121], 'affinity': [112], 'analysis,': [113], 'further': [115], 'find': [116], 'promotes': [119], 'microtubules.': [123], 'tubulin': [126], 'polymerization': [127], 'shows': [129], 'enhances': [132], 'promote': [138], 'assembly.': [140], 'These': [141], 'results': [142], 'demonstrate': [143], 'mediates': [146], 'via': [152], 'microtubule‐dependent': [154], 'mechanism.': [155], 'Copyright': [156], '©': [157], '2012': [158], 'Pathological': [159], 'Society': [160], 'Great': [162], 'Britain': [163], 'Ireland.': [165], 'Published': [166], 'John': [168], 'Wiley': [169], '&': [170], 'Sons,': [171], 'Ltd.': [172]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2138078973', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 3}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 7}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 6}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-08-13T19:39:03.954601', 'created_date': '2016-06-24'}