Mass Spectrometric Characterization of Proteins from the SARS Virus

Name: Work Video:
Duration: 3 min 30 s
Oleg V. Krokhin; Yan Li; Anton Andonov; Heinz Feldmann; Ramon Flick; Steven J.M. Jones; Ute Ströeher; Nathalie Bastien; Kumar Dasuri; Keding Cheng; J. Neil Simonsen; Hélène Perreault; John A. Wilkins; Werner Ens; Frank Plummer; Kenneth G. Standing
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'abstract_inverted_index': {'A': [0, 95, 174, 269, 1848, 2331, 2476, 2702, 2848, 2991, 3153, 3822, 4034], 'new': [1, 175, 384, 2913, 3099, 3154], 'coronavirus': [2, 176, 794, 819, 1037, 1431, 3251, 3281, 3309, 3391, 3395, 3743, 3775, 4098], 'has': [3, 106, 177, 280, 386, 428, 617, 773, 1078, 1114, 2510, 4128], 'been': [4, 108, 178, 282, 387, 727, 1116, 3406, 3461, 4130], 'implicated': [5, 179], 'as': [6, 58, 180, 232, 1301, 2312, 2419, 2421, 2618, 2761, 3423, 3479, 3481, 3772, 3794, 3871, 3873, 3880, 3892, 3971, 4084, 4111, 4152], 'the': [7, 29, 45, 83, 89, 101, 134, 143, 159, 181, 203, 219, 257, 263, 275, 308, 317, 333, 373, 437, 487, 491, 507, 520, 537, 545, 592, 619, 639, 695, 730, 744, 763, 770, 788, 801, 804, 808, 814, 818, 942, 1051, 1059, 1062, 1072, 1203, 1209, 1244, 1295, 1305, 1308, 1324, 1332, 1383, 1429, 1476, 1501, 1506, 1539, 1571, 1596, 1630, 1642, 1690, 1697, 1702, 1721, 1763, 1909, 1929, 1948, 1972, 2009, 2127, 2136, 2156, 2173, 2176, 2190, 2209, 2221, 2227, 2246, 2282, 2301, 2361, 2388, 2391, 2410, 2422, 2431, 2435, 2444, 2494, 2503, 2519, 2543, 2564, 2572, 2607, 2622, 2642, 2648, 2744, 2749, 2765, 2769, 2779, 2784, 2790, 2801, 2804, 2809, 2822, 2827, 2832, 2837, 2841, 2851, 2856, 2860, 2881, 2920, 2926, 2932, 2939, 2945, 2975, 2979, 2982, 3001, 3006, 3028, 3032, 3044, 3046, 3078, 3112, 3119, 3129, 3182, 3204, 3229, 3236, 3241, 3269, 3274, 3303, 3318, 3331, 3338, 3345, 3353, 3357, 3366, 3372, 3383, 3389, 3397, 3420, 3433, 3469, 3514, 3643, 3763, 3769, 3774, 3782, 3787, 3799, 3810, 3815, 3828, 3836, 3845, 3862, 3876, 3925, 3932, 3943, 3948, 3957, 3984, 3990, 3996, 4005, 4011, 4030, 4037, 4040, 4088, 4092, 4096, 4115, 4137, 4150], 'causative': [8, 182], 'agent': [9, 183], 'of': [10, 88, 133, 184, 262, 307, 352, 356, 368, 425, 510, 536, 601, 624, 689, 743, 941, 1034, 1061, 1108, 1138, 1172, 1202, 1212, 1273, 1307, 1314, 1334, 1392, 1414, 1485, 1500, 1527, 1538, 1599, 1641, 1714, 1740, 1781, 1824, 1866, 1876, 1919, 1928, 1951, 2011, 2041, 2126, 2155, 2189, 2220, 2257, 2360, 2385, 2434, 2437, 2443, 2479, 2493, 2518, 2542, 2609, 2613, 2624, 2678, 2720, 2730, 2748, 2768, 2803, 2880, 2931, 2938, 2944, 2974, 2993, 3004, 3061, 3071, 3077, 3118, 3131, 3156, 3184, 3203, 3240, 3259, 3266, 3292, 3300, 3330, 3344, 3352, 3365, 3411, 3430, 3446, 3501, 3642, 3740, 3786, 3824, 3844, 3861, 3867, 3875, 3895, 3918, 3980, 4020, 4036, 4065, 4091, 4095, 4101, 4106], 'severe': [11, 185, 389, 444, 602, 1040, 1393, 1486, 3746], 'acute': [12, 186, 390, 399, 445, 603, 1041, 1394, 1487, 3747], 'respiratory': [13, 187, 391, 400, 446, 539, 604, 1042, 1395, 1488, 3748], 'syndrome': [14, 188, 392, 447, 541, 605, 1396, 1489], '(SARS).': [15, 189], 'We': [16, 190], 'have': [17, 191, 371, 726, 2549, 2844, 3964], 'used': [18, 192, 396, 1533, 1546, 2007, 2217], 'convalescent': [19, 193, 1552, 1559, 1655], 'sera': [20, 194, 1560], 'from': [21, 32, 195, 206, 480, 717, 1177, 1323, 1412, 1505, 1555, 1657, 1689, 1754, 1783, 1887, 1904, 2187, 2196, 2202, 2208, 2226, 2366, 2387, 2440, 2645, 2789, 2859, 2877, 2929, 2957, 3115, 3363, 3661, 3798, 3947], 'several': [22, 196, 441, 956, 1413, 3662], 'SARS': [23, 38, 197, 212, 501, 621, 693, 723, 1309, 1556, 1659, 3358, 3390, 4097], 'patients': [24, 198, 691, 718, 1416], 'to': [25, 35, 65, 100, 131, 199, 209, 239, 274, 305, 377, 431, 486, 729, 812, 1070, 1080, 1293, 1419, 1534, 1547, 1565, 1570, 1595, 1619, 1720, 1762, 1873, 2150, 2160, 2168, 2244, 2270, 2465, 2512, 2536, 2562, 2576, 2597, 2727, 2742, 2774, 3043, 3059, 3111, 3128, 3218, 3261, 3376, 3491, 3760, 3808, 3956, 4002, 4004, 4054, 4077, 4082, 4148, 4160], 'detect': [26, 200], 'proteins': [27, 201, 1073, 1121, 1782, 4056], 'in': [28, 44, 82, 123, 171, 202, 218, 256, 297, 345, 418, 421, 423, 469, 472, 476, 490, 503, 506, 606, 638, 694, 724, 769, 778, 1097, 1118, 1144, 1179, 1284, 1299, 1304, 1397, 1490, 1510, 1583, 1593, 1671, 1792, 1797, 1916, 1923, 1940, 2047, 2172, 2276, 2300, 2409, 2413, 2447, 2467, 2471, 2484, 2499, 2507, 2595, 2606, 2759, 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222, 3767, 4110], 'by': [49, 77, 110, 223, 251, 284, 955, 1140, 1216, 1280, 1422, 1573, 1634, 1693, 1766, 1821, 1966, 2067, 2214, 2235, 2260, 2268, 2289, 2295, 2314, 2358, 2554, 2651, 2675, 2764, 3189, 3228, 3325, 3506, 3510, 3658, 3768, 3924, 4010, 4114], 'matrix-assisted': [50, 224, 451, 1953, 2338], 'laser': [51, 225, 404, 452, 1954, 2339, 2370], 'desorption/ionization': [52, 226, 453, 1955, 2340], 'time-of-flight': [53, 227, 466, 1110, 1217, 3191], 'mass': [54, 228, 412, 460, 463, 1076, 1111, 1218, 1281, 1713, 1831, 1982, 2158, 2291, 2297, 2306, 2334, 2397, 2685, 3192, 3837, 3856, 3979], 'spectrometry': [55, 229, 461, 464, 1077, 1096, 1112, 2292, 2298, 3193], '(MALDI-TOF': [56, 230], 'MS)': [57, 231], 'a': [59, 67, 147, 164, 233, 241, 321, 338, 353, 360, 379, 477, 524, 792, 951, 1035, 1056, 1173, 1302, 1515, 1587, 1654, 1658, 1666, 1705, 1798, 1822, 1829, 1952, 1978, 2019, 2038, 2068, 2073, 2161, 2197, 2203, 2337, 2367, 2396, 2406, 2457, 2513, 2550, 2555, 2585, 2610, 2676, 2683, 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[84, 258], 'published': [85, 259], 'nucleotide': [86, 260, 805, 3499, 3926, 4012], 'sequence': [87, 261, 816, 940, 1053, 1207, 2747, 2862, 3417, 3500, 3641, 3785, 3830, 3847, 3934, 4013, 4090], 'same': [90, 264, 2495, 3949], 'virus': [91, 265, 1215, 1543, 1572, 1631, 3359], 'isolate': [92, 266, 1530], '(>96%': [93, 267], 'coverage).': [94, 114, 268, 288, 4033], 'second': [96, 270, 1525], 'viral': [97, 271, 1063, 1098, 1120, 1337, 1529], 'corresponding': [99, 273], '∼139-kDa': [103, 277, 4006], 'spike': [104, 160, 278, 334, 4055, 4093, 4138], 'glycoprotein': [105, 161, 279, 335], 'also': [107, 137, 281, 311, 3460, 3858, 4124], 'examined': [109, 283, 4131], 'MALDI-TOF': [111, 285], 'MS': [112, 286, 2415, 3102], '(42%': [113, 287], 'After': [115, 289], 'peptide': [116, 290, 454, 1819, 1878, 1910, 2236, 2531, 2573, 2590, 2673, 2732, 2755, 2985], 'N-glycosidase': [117, 291, 407, 455, 2237], 'F': [118, 292, 456, 2238, 4147], 'digestion,': [119, 293, 1629], '12': [120, 294], 'glycosylation': [121, 295, 2248, 4067, 4135], 'sites': [122, 135, 296, 309, 4068, 4113], 'this': [124, 298, 1086, 1315, 1528, 1542, 1621, 2170, 2353, 2480, 2601, 3287, 3454, 4043], 'were': [126, 136, 300, 310, 1328, 1417, 1562, 1686, 1718, 1735, 1759, 1902, 1912, 1975, 1987, 2006, 2016, 2130, 2143, 2183, 2285, 2604, 3108, 3442, 3477, 3792, 3806, 4000, 4022], 'confirmed.': [127, 301], 'sugars': [129, 303], 'attached': [130, 304], 'four': [132, 306], 'identified.': [138, 312], 'These': [139, 313, 1717], 'results': [140, 314, 1313, 3239, 3660, 3826, 3930], 'suggest': [141, 315], 'is': [146, 320, 753, 1069, 1249, 2425, 2482, 2497, 2527, 2795, 2863, 3012, 3278, 3306, 3314, 3334, 3360, 3831, 4045, 4052], 'major': [148, 322], 'immunogen': [149, 323], 'may': [151, 162, 325, 336, 795, 4123], 'useful': [153, 327], 'for': [154, 168, 328, 342, 500, 737, 748, 758, 807, 817, 960, 1058, 1085, 1208, 1291, 1331, 1425, 1568, 1627, 1724, 1850, 1980, 2008, 2102, 2116, 2218, 2704, 2807, 2872, 3000, 3031, 3051, 3220, 3385, 3666, 4025, 4042], 'early': [155, 329], 'diagnostics,': [156, 330], 'and': [157, 331, 427, 440, 523, 534, 634, 686, 750, 761, 1075, 1248, 1266, 1336, 1408, 1428, 1677, 1701, 1828, 1893, 1914, 1945, 1971, 2003, 2035, 2065, 2097, 2111, 2200, 2216, 2294, 2343, 2403, 2416, 2470, 2474, 2487, 2548, 2616, 2637, 2682, 2772, 2811, 2855, 2869, 2874, 2942, 2959, 2997, 3021, 3027, 3067, 3103, 3126, 3151, 3194, 3254, 3295, 3322, 3392, 3409, 3471, 3473, 3848, 3852, 3865, 3888, 3907, 4018, 4039, 4081], 'present': [163, 337, 2174], 'particularly': [165, 339], 'attractive': [166, 340], 'target': [167, 341, 1979, 2076, 2362], 'prophylactic': [169, 343], 'intervention': [170, 344], 'combating': [172, 346], 'SARS.': [173, 347], 'recent': [349], 'clinical': [350], 'identification': [351, 4031], 'type': [355], 'atypical': [357], 'pneumonia': [358], 'without': [359], 'clearly': [361, 2753, 2815, 3307], 'defined': [362, 3960], 'etiology,': [363], 'together': [364, 3432], 'with': [365, 626, 692, 719, 1039, 1551, 1586, 1653, 1679, 1710, 1727, 1738, 1935, 2037, 2058, 2336, 2363, 2377, 3186, 3210, 3263, 3350, 3371, 3745, 3827, 3942, 4145], 'epidemiological': [366], 'evidence': [367, 3384], 'high': [369, 3048, 3297], 'transmissibility,': [370], 'provoked': [372], 'World': [374], 'Health': [375, 735], 'Organization': [376], 'issue': [378], 'rare': [380], 'travel': [381], 'advisory.': [382], 'entity': [385], 'called': [388], '(SARS)': [393], '1The': [394], 'abbreviations': [395], 'are:': [397], 'SARSsevere': [398], 'syndromeNMLNational': [401], 'Microbiology': [402, 449, 590, 732, 1381, 1474], 'LaboratoryMALDImatrix-assisted': [403], 'desorption/ionizationPNGase': [405], 'Fpeptide': [406], 'FHPLChigh-performance': [408], 'liquid': [409, 458, 1968], 'chromatographyMSmass': [410], 'spectrometryMS/MStandem': [411], 'spectrometryQqTOFquadrupole/time-of-flightTOFtime-of-flight.': [413], ';': [414], 'it': [415, 1288, 2583], 'apparently': [416], 'began': [417, 471, 547], 'Guangdong': [419, 504], 'province': [420, 505], 'China': [422], 'November': [424], '2002': [426], 'since': [429], 'spread': [430], 'Hong': [432, 481, 492], 'Kong,': [433], 'Singapore,': [434], 'Vietnam,': [435], 'Canada,': [436, 736], 'U.S.,': [438], 'Taiwan,': [439], 'European': [442], 'countries.': [443], 'National': [448, 589, 731, 1380, 1473], 'Laboratory': [450, 591, 733, 1382, 1475], 'high-performance': [457], 'chromatography': [459, 1969], 'tandem': [462, 2296, 2332], 'quadrupole/time-of-flight': [465, 1830, 2333, 2684], 'outbreak': [468, 622], 'Canada': [470, 588, 616, 725, 1379, 1472], 'late': [473], 'February': [474], '2003': [475], 'traveler': [478], 'returning': [479], 'Kong': [482, 493], 'whose': [483], 'exposure': [484, 533], 'index': [488, 514], 'case': [489, 515, 1326], 'epidemic': [494], '(a': [495, 3283], 'physician': [496], 'who': [497], 'had': [498, 2181, 3289, 3405, 3459], 'cared': [499], 'cases': [502, 633], "People's": [508], 'Republic': [509], 'China).': [511], 'Canadian': [513, 593, 711, 745, 1384, 1477], 'died': [516, 535], '9': [517], 'days': [518, 531, 543], 'after': [519, 532, 544, 1522, 2538], 'disease': [521, 1143], 'onset,': [522], '43-year-old': [525, 1507], 'male': [526, 1508], 'relative': [527], 'became': [528, 3758], 'ill': [529], '2': [530, 1241, 2469], 'adult': [538], 'distress': [540], '15': [542], 'illness': [546], '(1Poutanen': [548, 1339, 1432], 'S.M.': [549, 681, 843, 1340, 1433, 3544], 'Low': [550, 1341, 1434], 'D.E.': [551, 869, 1342, 1435, 3570], 'Henry': [552, 1343, 1436], 'B.': [553, 925, 978, 1012, 1158, 1344, 1437, 1811, 2665, 3626, 3684, 3718], 'Finkelstein': [554, 1345, 1438], 'S.': [555, 903, 913, 919, 976, 984, 1010, 1022, 1127, 1162, 1188, 1346, 1439, 3174, 3604, 3614, 3620, 3682, 3690, 3716, 3728], 'Rose': [556, 650, 1347, 1440], 'D.': [557, 565, 845, 887, 923, 996, 1348, 1356, 1441, 1449, 1845, 2699, 3546, 3588, 3624, 3702], 'Green': [558, 1349, 1442], 'K.': [559, 883, 980, 1016, 1268, 1350, 1443, 3584, 3686, 3722], 'Tellier': [560, 1351, 1444], 'R.': [561, 563, 895, 921, 972, 1020, 1092, 1154, 1352, 1354, 1445, 1447, 3596, 3622, 3678, 3726, 3899], 'Draker': [562, 1353, 1446], 'Adachi': [564, 1355, 1448], 'Ayers': [566, 1357, 1450], 'M.': [567, 581, 583, 659, 853, 889, 891, 897, 899, 929, 931, 990, 1018, 1269, 1358, 1372, 1374, 1451, 1465, 1467, 1773, 1777, 1813, 1815, 2326, 2667, 2669, 3554, 3590, 3592, 3598, 3600, 3630, 3632, 3696, 3724], 'Chan': [568, 838, 1359, 1452, 3539], 'A.K.': [569, 1360, 1453], 'Skowronski': [570, 932, 1361, 1454, 3633], 'D.M.': [571, 933, 1362, 1455, 3634], 'Salit': [572, 1363, 1456], 'I.': [573, 665, 1131, 1194, 1259, 1364, 1457, 1805, 2659], 'Simor': [574, 1365, 1458], 'A.E.': [575, 1366, 1459], 'Slutsky': [576, 1367, 1460], 'A.S.': [577, 683, 861, 1368, 1461, 3562], 'Doyle': [578, 1369, 1462], 'P.W.': [579, 1370, 1463, 3178], 'Krajden': [580, 928, 1371, 1464, 3629], 'Petric': [582, 930, 1373, 1466, 3631], 'Brunham': [584, 926, 1375, 1468, 3627], 'R.C.': [585, 927, 1376, 1469, 3628], 'McGeer': [586, 1377, 1470], 'A.J.': [587, 1378, 1471], 'Severe': [594, 1385, 1478], 'Acute': [595, 1386, 1479], 'Respiratory': [596, 1387, 1480], 'Syndrome': [597, 1388, 1481], 'Study': [598, 1389, 1482], 'Team': [599, 1390, 1483], 'Identification': [600, 1391, 1484], 'Canada.N.': [607, 1398, 1491], 'Engl.': [608, 1399, 1492], 'J.': [609, 833, 1014, 1400, 1493, 3534, 3720], 'Med.': [610, 700, 1401, 1494], '2003;': [611, 704, 947, 1046, 1402, 1495, 1882, 2736, 3648, 3752], '348:': [612, 1403, 1496], '1995-2005Google': [613, 1404, 1497], 'Scholar).': [614, 715, 1049, 1105, 1405, 1498, 1616, 2122, 2351, 2739, 3755], 'Subsequently,': [615], 'faced': [618], 'largest': [620], 'outside': [623], 'Asia,': [625], 'at': [627, 1243, 2077, 2966, 3495, 3513, 3952, 3976, 4120], 'least': [628], '351': [629], 'probable': [630, 722], 'or': [631, 721, 1751, 1795, 2558, 2627, 4070], 'suspected': [632, 720], '27': [635], 'deaths,': [636], 'mostly': [637], 'Toronto': [640, 697], 'area': [641], '(2Booth': [642], 'C.M.': [643, 2252], 'Matukas': [644], 'L.M.': [645], 'Tomlinson': [646], 'G.A.': [647, 917, 3618], 'Rachlis': [648], 'A.R.': [649], 'D.B.': [651], 'Dwosh': [652], 'H.A.': [653], 'Walmsley': [654], 'S.L.': [655], 'Mazzulli': [656], 'T.': [657, 1843, 2697], 'Avendano': [658], 'Derkach': [660], 'P.': [661, 1160], 'Ephtimios': [662], 'I.E.': [663], 'Kitai': [664], 'Mederski': [666], 'B.D.': [667], 'Shadowitz': [668], 'S.B.': [669, 857, 3558], 'Gold': [670], 'W.L.': [671], 'Hawryluck': [672], 'L.A.': [673], 'Rea': [674], 'E.': [675], 'Chenkin': [676], 'J.S.': [677], 'Cescon': [678], 'D.W.': [679], 'Poutanen': [680], 'Detsky': [682], 'Clinical': [684, 1320], 'features': [685], 'short-term': [687], 'outcomes': [688], '144': [690], 'greater': [696], 'area.J.': [698], 'Am.': [699], 'Assoc.': [701], 'May': [702, 945, 1044, 3646, 3750], '6,': [703], '289:': [705], '2801-2809Google': [706], 'Scholar,': [707, 1150, 1184, 1225, 1257, 1839, 1858, 2693, 2712, 3166], '3Health': [708], 'Canada.': [709], 'Latest': [710], 'Numbers': [712], 'on': [713, 1519, 1665, 1947, 1977, 2108, 2281, 2567, 2831, 3419, 3468], 'SARS.http://www.hc-sc.gc.ca/english/protection/warnings/sars/sars_numbers.htmlGoogle': [714], 'Samples': [716, 2013], 'referred': [728], '(NML),': [734], 'laboratory': [738, 802, 1113, 1297], 'diagnostics.': [739], 'laboratory,': [741], 'part': [742], 'Science': [746], 'Centre': [747, 3518], 'Human': [749], 'Animal': [751], 'Health,': [752], "Canada's": [754], 'national': [755], 'reference': [756], 'center': [757], 'infectious': [759, 3502, 3950], 'diseases': [760], 'houses': [762], 'only': [764, 2177, 3293, 3341], 'Class': [765], '4': [766, 1521, 1648], 'containment': [767], 'facilities': [768], 'country.': [771], 'NML': [772, 1292], 'played': [774], 'active': [776, 1117], 'role': [777], 'intensive': [780], 'international': [781], 'collaborative': [782], 'effort': [783, 811, 2171], 'among': [784], '11': [785], 'laboratories': [786, 958, 1723, 3664], 'around': [787], 'world': [789], 'suggested': [791], 'distinct': [793], 'etiologically': [797], 'involved.': [798], 'In': [799, 1617, 2352, 2740, 3017, 3233, 3954], 'particular,': [800, 3380], 'prepared': [803, 1886, 3505], 'samples': [806, 1554, 2186, 2603, 3944], 'first': [809, 1245, 1312, 2234, 3110, 3319], 'successful': [810], 'determine': [813, 2743], 'genome': [815, 939, 1052, 3640], '(4Marra': [820, 3521], 'M.A.': [821, 1028, 3522, 3734], 'Jones': [822, 902, 3523, 3603], 'S.J.': [823, 3524], 'Astell': [824, 3525], 'C.R.': [825, 3526], 'Holt': [826, 3527], 'R.A.': [827, 3528], 'Brooks-Wilswon': [828, 3529], 'A.': [829, 841, 867, 877, 901, 907, 909, 986, 1008, 1164, 1192, 1771, 1803, 2657, 3168, 3170, 3172, 3176, 3530, 3542, 3568, 3578, 3602, 3608, 3610, 3692, 3714], 'Butterfield': [830, 3531], 'Y.S.': [831, 3532], 'Khattra': [832, 3533], 'Asano': [834, 3535], 'J.K.': [835, 3536], 'Barber': [836, 3537], 'S.A.': [837, 3538], 'S.Y.': [839, 3540], 'Cloutier': [840, 3541], 'Coughlin': [842, 3543], 'Freeman': [844, 3545], 'Girn': [846, 3547], 'N.': [847, 881, 3548, 3582], 'Griffith': [848, 3549], 'O.L.': [849, 3550], 'Leach': [850, 3551], 'S.R.': [851, 3552], 'Mayo': [852, 3553], 'McDonald': [854, 3555], 'H.': [855, 879, 905, 1196, 3556, 3580, 3606], 'Montgomery': [856, 3557], 'Pandoh': [858, 3559], 'P.K.': [859, 3560], 'Petrescu': [860, 3561], 'Robertson': [862, 3563], 'A.G.': [863, 3564], 'Schein': [864, 3565], 'J.E.': [865, 3566], 'Siddiqui': [866, 3567], 'Smailus': [868, 3569], 'Stott': [870, 3571], 'J.M.': [871, 3572], 'Yang': [872, 3573], 'G.S.': [873, 3574], 'Plummer': [874, 2253, 3575], 'F.': [875, 3140, 3576, 3901], 'Andonov': [876, 3577], 'Artsob': [878, 3579], 'Bastien': [880, 3581], 'Bernard': [882, 3583], 'Booth': [884, 3585], 'T.F.': [885, 3586], 'Bowness': [886, 3587], 'Czub': [888, 3589], 'Drebot': [890, 3591], 'Fernando': [892, 3593], 'L.': [893, 988, 3594, 3694], 'Flick': [894, 3595], 'Garbutt': [896, 3597], 'Gray': [898, 3599], 'Grolla': [900, 3601], 'Feldmann': [904, 3605], 'Meyers': [906, 3607], 'Kabani': [908, 3609], 'Li': [910, 3611], 'Y.': [911, 1262, 2083, 3612], 'Normand': [912, 3613], 'Stroher': [914, 3615], 'U.': [915, 3616], 'Tipples': [916, 3617], 'Tyler': [918, 3619], 'Vogrig': [920, 3621], 'Ward': [922, 3623], 'Watson': [924, 3625], 'Upton': [934, 3635], 'C.': [935, 1002, 1026, 1862, 1864, 2716, 2718, 3636, 3708, 3732], 'Roper': [936, 3637], 'R.L.': [937, 3638], 'SARS-associated': [943, 3644], 'coronavirus.Science.': [944, 3645], '1,': [946, 1045, 3647, 3751], '300:': [948, 1047, 3649, 3753], '1399-1404Google': [949, 3650], 'Scholar),': [950, 1286, 2266, 3916], 'result': [952, 3894, 3940], 'soon': [953, 3480, 3656, 3757], 'confirmed': [954, 4029], 'other': [957, 1624, 1703, 1900, 3339, 3354, 3367, 3373, 3394, 3663, 3869, 4058], '(see,': [959], 'example,': [961, 2783], 'Ref.': [962, 3668], '5Rota': [963, 3669], 'P.A.': [964, 3670], 'Oberste': [965, 3671], 'M.S.': [966, 3672], 'Monroe': [967, 3673], 'S.S.': [968, 3674], 'Nix': [969, 3675], 'W.A.': [970, 3676], 'Campagnoli': [971, 3677], 'Icenogle': [973, 3679], 'J.P.': [974, 3680], 'Penaranda': [975, 3681], 'Bankamp': [977, 3683], 'Maher': [979, 3685], 'Chen': [981, 993, 3687, 3699], 'M.H.': [982, 3688], 'Tong': [983, 3689], 'Tamin': [985, 3691], 'Lowe': [987, 3693], 'Frace': [989, 3695], 'DeRisi': [991, 3697], 'J.L.': [992, 3698], 'Q.': [994, 3700], 'Wang': [995, 3701], 'Erdman': [997, 3703], 'D.D.': [998, 3704], 'Peret': [999, 3705], 'T.C.': [1000, 3706], 'Burns': [1001, 3707], 'Ksiazek': [1003, 3709], 'T.G.': [1004, 3710], 'Rollin': [1005, 3711], 'P.E.': [1006, 3712], 'Sanchez': [1007, 3713], 'Liffick': [1009, 3715], 'Holloway': [1011, 3717], 'Limor': [1013, 3719], 'McCaustland': [1015, 3721], 'Olsen-Rasmussen': [1017, 3723], 'Fouchier': [1019, 3725], 'Gunther': [1021, 3727], 'Osterhaus': [1023, 3729], 'A.D.': [1024, 3730], 'Drosten': [1025, 3731], 'Pallansch': [1027, 3733], 'Anderson': [1029, 3735], 'L.J.': [1030, 3736], 'Bellini': [1031, 3737], 'W.J.': [1032, 3738], 'Characterization': [1033, 1171, 3739], 'associated': [1038, 3744], 'syndrome.Science.': [1043, 3749], '1394-1399Google': [1048, 3754], 'Nevertheless,': [1050], 'merely': [1054], 'provides': [1055], 'template': [1057], 'construction': [1060], 'proteins.': [1064, 1310, 4086], 'Thus,': [1065, 3302, 4072], 'alternative': [1067], 'strategy': [1068], 'examine': [1071], 'themselves,': [1074], 'proved': [1079], 'efficient': [1083], 'tool': [1084, 1849, 2703], 'purpose': [1087], '(6Thomas': [1088], 'J.J.': [1089], 'Bakhtiar': [1090], 'R.,': [1091], 'Siuzdak': [1093], 'G.': [1094], 'Mass': [1095, 1252, 1778, 1834, 1853, 2103, 2109, 2117, 2346, 2688, 2707], 'proteomics.Acc.': [1099], 'Chem.': [1100, 1221, 1786, 3198], 'Res.': [1101, 1881, 2735, 3162], '2001;': [1102, 1222, 1855, 2709, 3199], '33:': [1103], '179-187Google': [1104], 'University': [1107], 'Manitoba': [1109], 'already': [1115], 'characterizing': [1119], '(7Seifers': [1122], 'D.L.': [1123, 1152, 1190], 'Harvey': [1124], 'T.L.': [1125, 3142], 'Haber': [1126, 1161, 1187], 'She': [1128, 1167, 1228], 'Y.-M.': [1129, 1168], 'Chernushevich': [1130, 1193, 1804, 2658], 'Ens': [1132, 1165, 1197, 1230, 1806, 2090, 2327, 2660, 3177], 'W.': [1133, 1166, 1198, 1231, 1807, 2091, 2328, 2661], 'Standing': [1134, 1169, 1199, 1808, 2088, 2329, 2662, 3179], 'K.G.': [1135, 1170, 1200, 1809, 2089, 2330, 2663, 3180], 'Natural': [1136], 'infection': [1137], 'sorghum': [1139], 'foxtail': [1141], 'mosaic': [1142, 1214], 'Kansas.Plant': [1145], 'Dis.': [1146], '1999;': [1147], '83:': [1148], '905-912Google': [1149], '8Seifers': [1151], 'Salomon': [1153], 'Marie-Jeanne': [1155], 'V.': [1156, 2087], 'Alliot': [1157], 'Signoret': [1159], 'Loboda': [1163, 1191, 3169], 'potyvirus': [1175], 'isolated': [1176], 'maize': [1178], 'Israel.Phytopathology.': [1180], '2000;': [1181, 2348], '90:': [1182], '505-513Google': [1183], '9She': [1185], 'Y.-M': [1186, 1229], 'Seifers': [1189], 'Perreault': [1195], 'Determination': [1201], 'complete': [1204, 3315, 3416], 'amino': [1205, 2461, 2745, 3034, 3783], 'acid': [1206, 1673, 1937, 2060, 2462, 2746, 3035, 3784], 'coat': [1210], 'brome': [1213], 'spectrometry.J.': [1219], 'Biol.': [1220], '276:': [1223], '20039-20047Google': [1224], '10Swanson': [1226], 'M.I.': [1227], 'Brown': [1232], 'E.G.': [1233], 'Coombs': [1234], 'K.M.': [1235], 'Mammalian': [1236], 'reovirus': [1237, 1274], 'core': [1238], 'micro': [1240], 'initiates': [1242], 'start': [1246], 'codon': [1247], 'acetylated.Rapid': [1250], 'Commun.': [1251, 1833, 1852, 2345, 2687, 2706], 'Spectrom.': [1253, 1835, 1854, 2347, 2689, 2708], '2002;': [1254], '16:': [1255], '2317-2324Google': [1256], '11Mendez,': [1258], 'I.,': [1260], 'She,': [1261], 'M.,': [1263], 'Ens,': [1264], 'W.,': [1265], 'Coombs,': [1267], '(2003)': [1270], 'Digestion': [1271], 'pattern': [1272], 'outer': [1275], 'capsid': [1276], 'σ3': [1278], 'determined': [1279], 'spectrometry.': [1282], 'Virology,': [1283], 'pressGoogle': [1285], 'so': [1287, 2140, 3356], 'natural': [1290], 'enlist': [1294], 'university': [1296, 1722], '(late': [1298], 'March)': [1300], 'collaborator': [1303], 'analysis': [1306, 2154, 2219], 'collaboration': [1316], 'are': [1317, 2356, 2522, 2533, 2545, 2814, 2917, 3244, 3250, 4074, 4109], 'described': [1318, 1765, 2619, 3107, 4153], 'below.': [1319], 'specimens': [1321], 'obtained': [1322, 3509], 'original': [1325, 2147], 'cluster': [1327], 'extensively': [1329, 4079], 'investigated': [1330], 'presence': [1333, 2608], 'bacterial': [1335, 3284], 'pathogens': [1338], 'Nasopharyngeal': [1406], 'swab': [1407], 'bronchoalveolar': [1409, 1502], 'fluids': [1411], 'these': [1415, 3211, 3403, 3487, 4021, 4102], 'positive': [1421, 1567], 'reverse': [1423], 'transcription-PCR': [1424], 'human': [1426], 'metapneumovirus': [1427], 'Inoculation': [1499], 'fluid': [1504], 'patient': [1509], 'Vero': [1511], 'E6': [1512], 'produced': [1514, 2357], 'strong': [1516], 'cytopathic': [1517], 'effect': [1518], 'day': [1520], 'infection.': [1523], 'passage': [1526], 'further': [1532], 'produce': [1535, 2271, 2395], 'large': [1536, 4063], 'quantities': [1537], 'virus.': [1540], 'Initially,': [1541], 'material': [1544, 3483, 3503], 'assess': [1548], 'its': [1549], 'antigenicity': [1550], 'serum': [1553, 1656], 'patients.': [1557], 'previously': [1563], 'antibodies': [1569], 'indirect': [1574], 'immunofluorescence': [1575], 'assay': [1576], '2Y.': [1577], 'Li,': [1578], 'unpublished': [1579], 'data.': [1580, 3927], 'strongly': [1581, 1652], 'reacted': [1582, 1651], 'Western': [1584, 1639], 'blot': [1585], '(Fig.': [1590, 1682, 3987], '1A)': [1591], 'similar': [1592, 3377, 3659], 'size': [1594], 'coronaviruses': [1600, 3332], '(12Lai': [1601], 'M.M.C.': [1602], 'Holmes': [1603], 'K.V.': [1604], 'Fields': [1605], 'Virology.': [1606], '4th': [1607], 'Ed.': [1608], 'Lippincott': [1609], 'Williams': [1610], '&': [1611], 'Wilkins,': [1612], 'Hagerstown,': [1613], 'MD2001:': [1614], '1163-1185Google': [1615], 'order': [1618, 2596, 2741, 3217], 'prepare': [1620], '(and': [1622], 'perhaps': [1623, 3474], 'SARS-related': [1625], 'proteins)': [1626], 'proteolytic': [1628, 1729, 1867, 2721, 2750, 3816], 'purified': [1633], '20–60%': [1635], 'linear': [1636, 2039], 'sucrose': [1637], 'gradient.': [1638], 'blotting': [1640], 'gradient': [1643, 2040], 'fractions': [1644, 1965, 1974, 2142, 2544], 'showed': [1645], 'fraction': [1647, 1662, 2490], '(density,': [1649], '1.18g/cm3)': [1650], 'run': [1664], 'Novex': [1667], '4–12%': [1668], 'Bis-Tris': [1669], 'gel': [1670, 1691, 3120, 3985], '4-morpholinepropanesulfonic': [1672], 'running': [1674], 'buffer': [1675], '(Invitrogen),': [1676], 'stained': [1678], 'Coomassie': [1680], 'blue': [1681], '1B).': [1683, 3988], 'Two': [1684], 'bands': [1685, 1734], 'then': [1687, 1925, 2267, 3127, 3214], 'excised': [1688, 1732], '(indicated': [1692], 'arrowheads),': [1694], 'containing': [1696, 1704, 1908, 2460, 2491, 2634, 2641, 2647, 2840, 2978], 'much': [1706, 2523], 'weaker': [1707, 2520], 'band': [1709, 3975], 'apparent': [1712, 3978], '∼180': [1715, 3981], 'kDa.': [1716], 'transferred': [1719], 'in-gel': [1725, 1736], 'digestion': [1726, 2442, 3458], 'various': [1728], 'enzymes.': [1730], 'digested': [1737, 2231, 2605], 'three': [1741, 3342], 'different': [1742, 2514, 3362], 'enzymes': [1743], '(sequencing': [1744], 'grade-modified': [1745], 'trypsin': [1746, 2269], '(Promega,': [1747], 'Madison,': [1748], 'WI),': [1749], 'Lys-C,': [1750], 'Asp-N': [1752, 3457], '(both': [1753, 2274], 'Roche': [1755, 2241], 'Molecular': [1756, 2242], 'Biochemicals)).': [1757], 'Digestions': [1758], 'performed': [1760, 1988], 'according': [1761], 'procedure': [1764], 'Shevchenko': [1767, 3173], 'et': [1768], 'al.': [1769], '(13Shevchenko': [1770], 'Wilm': [1772, 1812, 2666], 'Vorm': [1774], 'O.': [1775, 2081], 'Mann': [1776, 1814, 2668], 'spectrometric': [1779, 1983], 'sequencing': [1780, 1820, 2591, 2674], 'polyacrylamide': [1784], 'gels.Anal.': [1785], '1996;': [1787], '68:': [1788], '850-858Google': [1789], 'Scholar)': [1790, 1885, 3202, 3651], 'either': [1791, 2625], 'ordinary': [1793, 1894, 2277, 2448, 2614], 'water': [1794, 2002, 2615], 'else': [1796], '1:1': [1799, 1934], 'H216O:H218O': [1800], 'mixture': [1801, 1911, 2436, 2612], '(14Shevchenko': [1802, 2656], 'Thomson': [1810, 1842, 2664, 2696], 'Rapid': [1816, 2670], "'de": [1817, 2671], "novo'": [1818, 2672], 'combination': [1823, 2677], 'nanoelectrospray,': [1825, 2679], 'isotopic': [1826, 2654, 2680, 2834], 'labeling': [1827, 2681], 'spectrometer.Rapid': [1832, 2686], '1997;': [1836, 2690, 3163], '11:': [1837, 2691], '1015-1024Google': [1838, 2692], '15Stewart': [1840, 2694], 'II': [1841, 2695], 'Figeys': [1844, 2698], '18O': [1846, 1868, 1874, 2626, 2700, 2722, 2728], 'labeling:': [1847, 1869, 2701, 2723], 'proteomics.Rapid': [1851, 2705], '15:': [1856, 2710], '2456-2465Google': [1857, 2711], '16Yao': [1859, 2713], 'X.': [1860, 2714], 'Alfonso': [1861, 2715], 'Fenselau': [1863, 2717], 'Dissection': [1865, 2719], 'Endoprotease': [1870, 2724], 'catalyzed': [1871, 2725], '16O': [1872, 2628, 2726], 'exchange': [1875, 2729], 'truncated': [1877, 2731], 'substrates.J.': [1879, 2733], 'Proteome': [1880, 2734], '2:': [1883, 2737], '147-152Google': [1884, 2738], '98%': [1888], 'H218O': [1889], '(Isotec,': [1890], 'Miamisburg,': [1891], 'OH)': [1892], 'water.': [1895], 'Unless': [1896], 'otherwise': [1897], 'noted,': [1898], 'all': [1899, 2825, 3005, 3249, 3255, 3868], 'chemicals': [1901], 'purchased': [1903], 'Sigma.': [1905], 'extracts': [1907], 'lyophilized': [1913, 2185], 'resuspended': [1915], '5.5': [1917], 'μl': [1918, 1927, 1961], '0.5%': [1920], 'trifluoroacetic': [1921, 2045], 'acit': [1922], 'water,': [1924, 2449], '0.5': [1926], 'resulting': [1930, 2439, 2785, 2946, 3114, 3877], 'sample': [1931, 2207, 2225], 'mixed': [1933, 2056], '2,5-dihydroxybenzoic': [1936], '(150': [1938], 'mg/ml': [1939], 'water:acetonitrile': [1941], '1:1)': [1942], 'matrix': [1943, 2061], 'solution': [1944, 2062], 'deposited': [1946, 1976, 2066], 'gold': [1949, 2075, 2283], 'surface': [1950], '(MALDI)': [1956], 'target.': [1957], 'remaining': [1959, 3811], '5': [1960], 'separated': [1963, 2213, 3467], 'into': [1964, 2390], 'micro-high-performance': [1967], '(μHPLC),': [1970], 'individual': [1973, 2530, 3421], 'subsequent': [1981, 2162, 2472], 'analysis.': [1984], 'Chromatographic': [1985], 'separations': [1986], 'using': [1989], 'Agilent': [1991], '1100': [1992], 'Series': [1993], 'system': [1994], '(Agilent': [1995], 'Technologies,': [1996], 'Wilmington,': [1997], 'DE).': [1998], 'Deionized': [1999], '(18': [2000], 'mΩ)': [2001], 'HPLC-grade': [2004], 'acetonitrile': [2005, 2043], 'preparation': [2010], 'eluents.': [2012], '(5': [2014], 'μl)': [2015], 'injected': [2017], 'onto': [2018, 2072], '150': [2020, 2023], 'μm': [2021], '×': [2022], 'mm': [2024], 'column': [2025, 2051], '(Vydac': [2026], '218': [2027], 'TP': [2028], 'C18,': [2029], '5μ;': [2030], 'Grace': [2031], 'Vydac,': [2032], 'Hesperia,': [2033], 'CA)': [2034, 2320, 2376], 'eluted': [2036, 2131], '1–80%': [2042], '(0.1%': [2044], 'acid)': [2046], '60': [2048], 'min.': [2049], 'effluent': [2052], '(4': [2053], 'μl/min)': [2054, 2064], 'on-line': [2057], 'dihydroxybenzoic': [2059], '(0.5': [2063], 'small': [2069, 2477], 'computer-controlled': [2070], 'robot': [2071], 'movable': [2074], '1-min': [2078], 'intervals': [2079], '(17Krokhin': [2080], 'Qian': [2082], 'McNabb': [2084], 'J.R.': [2085], 'Spicer': [2086], 'An': [2092], 'off-line': [2093], 'interface': [2094], 'between': [2095, 2850, 2954, 3317, 3388], 'HPLC': [2096, 2137, 2215, 2451, 2489, 2539], 'orthogonal': [2098], 'MALDI': [2099], 'TOF.American': [2100], 'Society': [2101, 2115], 'Spectrometry,': [2104, 2118], '50th': [2105], 'ASMS': [2106], 'Conference': [2107], 'Spectrometry': [2110], 'Allied': [2112], 'Topics.': [2113], 'American': [2114], 'Santa': [2119], 'Fe,': [2120], 'NM2002Google': [2121], 'vast': [2124], 'majority': [2125], 'tryptic': [2128, 2198, 2210, 2441, 2458, 2883, 2958, 3010, 3075, 3116, 3231, 3998, 4141], 'fragments': [2129, 2273, 2640, 3817], 'within': [2132, 2405, 3038], '40': [2133, 2141, 3260], 'min': [2134], 'under': [2135], 'condition': [2138], 'used,': [2139], 'normally': [2144, 2394], 'collected.': [2145], 'Our': [2146], 'intention': [2148], 'postpone': [2151], 'any': [2152, 2578, 3351, 3364, 3393], 'detailed': [2153], 'higher': [2157], 'investigation.': [2163], 'Later,': [2164], 'when': [2165], 'we': [2166, 2180, 3791, 3805, 3963], 'decided': [2167], 'include': [2169, 3849], 'measurements,': [2175, 4027], 'materials': [2178], 'available': [2182], 'two': [2184], 'digests': [2188, 3011, 3117], 'larger': [2191], '(∼180-kDa': [2193], 'band),': [2194], 'digest': [2199, 2211, 2229, 3076, 3999, 4142], 'Lys-C': [2204, 2228, 2960, 3133], 'digest.': [2205, 3134], 'glycosylated': [2222, 4080], 'peptides.': [2223], 'twice': [2232], 'more,': [2233], '(PNGase': [2239], 'F;': [2240], 'Biochemicals)': [2243], 'remove': [2245, 3809, 4149], 'asparagine-linked': [2247, 2258], '(18Tarentino': [2249], 'A.L.': [2250], 'Gomez': [2251], 'Jr.,': [2254], 'T.H.': [2255], 'Deglycosylation': [2256], 'glycans': [2259], 'peptide:N-glycosidase': [2261], 'F.Biochemistry.': [2262], '1985;': [2263], '24:': [2264], '4665-4671Google': [2265], 'smaller': [2272], 'digestions': [2275, 3476], 'water).': [2278], 'spots': [2280], 'targets': [2284], 'analyzed': [2286], 'individually,': [2287], 'both': [2288, 2414, 2635, 3018, 3850], 'single': [2290], '(MS)': [2293], '(MS/MS)': [2299], 'Manitoba/Sciex': [2302], 'prototype': [2303], 'quadrupole/TOF': [2304], '(QqTOF)': [2305], 'spectrometer': [2307, 2335], '(subsequent': [2308], 'commercial': [2309], 'model': [2310], 'sold': [2311], 'QSTAR': [2313], 'Applied': [2315], 'Biosystems/MDS': [2316], 'Sciex,': [2317], 'Foster': [2318], 'City,': [2319], '(19Loboda': [2321], 'A.V.': [2322], 'Krutchinsky': [2323], 'A.N.': [2324], 'Bromirski': [2325], 'source:': [2341], 'Design': [2342], 'performance.Rapid': [2344], '14:': [2349], '1047-1057Google': [2350], 'instrument,': [2354], 'ions': [2355, 2386, 2496, 2521, 2813, 2876, 2928, 2956, 3054], 'irradiation': [2359], 'photon': [2364], 'pulses': [2365], '20-Hz': [2368], 'nitrogen': [2369], '(VSL': [2371], '337ND,': [2372], 'Spectra-Physics,': [2373], 'Mountain': [2374], 'View,': [2375], '300': [2378], 'μJ': [2379], 'energy': [2380], 'per': [2381], 'pulse.': [2382], 'Orthogonal': [2383], 'injection': [2384], 'quadrupole': [2389, 2767], 'TOF': [2392, 2411], 'section': [2393], 'resolving': [2398], 'power': [2399], '10,000': [2400], 'full-width': [2401], 'half-maximum': [2402], 'accuracy': [2404], 'few': [2407, 3053], 'millidaltons': [2408], 'spectra': [2412, 2541, 2633, 3857], 'MS/MS': [2417, 2878, 3104, 4026], 'modes,': [2418], 'long': [2420], 'ion': [2423, 2506, 2756, 2787, 2977], 'peak': [2424], 'reasonably': [2426], 'intense.': [2427], 'Fig.': [2428, 2468, 2485, 2500, 2508, 2798, 2923, 2949, 2969, 3247, 3834, 3883], '2A': [2429], 'shows': [2430, 2925, 2951, 2971, 2987], 'm/z': [2432, 2791, 2853, 2995, 3025, 3066], 'spectrum': [2433, 2481, 2788, 2973], 'peptides': [2438, 3007, 3072, 3113, 3212, 3374, 3434, 3994], 'before': [2450], 'fractionation.': [2452], 'Note': [2453], 'Tx-y': [2455], 'indicates': [2456], 'fragment': [2459], 'residues': [2463, 3321, 3348, 4159], 'x': [2464], 'y': [2466, 2818, 2875], 'tables': [2473], 'discussion.': [2475], 'region': [2478, 3329], 'expanded': [2483], '2B,': [2486], 'some': [2492, 2517], 'shown': [2498, 2796, 3245, 3832, 3881], '2C.': [2501], 'Here,': [2502], 'intense': [2505, 4024], '2B': [2509], 'moved': [2511], 'fraction,': [2515], 'but': [2516, 4127], 'more': [2524, 3841], 'prominent.': [2525], 'It': [2526, 3756], 'clear': [2528, 3759], 'peaks': [2532, 3060], 'considerably': [2534], 'easier': [2535], 'distinguish': [2537], 'separation;': [2540], 'dramatically': [2546], 'simpler': [2547], 'signal-to-noise': [2551], 'ratio': [2552], 'improved': [2553], 'factor': [2556], '∼10': [2557, 3039], 'more.': [2559], 'Initial': [2560], 'efforts': [2561], 'identify': [2563], '(based': [2566], 'data': [2568, 3208, 3398, 3839, 4038], 'base': [2569, 3209], 'searching': [2570, 3136], 'against': [2571], 'fingerprint),': [2574], 'failed': [2575], 'yield': [2577, 3256], 'significant': [2579, 3386], 'matches,': [2580], 'suggesting': [2581], 'protein.': [2587], 'De': [2588], 'novo': [2589], 'therefore': [2593], 'undertaken': [2594, 3215], 'characterize': [2598], 'it.': [2599], 'For': [2600, 2782], 'purpose,': [2602], '50/50': [2611], 'H218O,': [2617], 'above,': [2620], 'because': [2621, 3440, 3494], 'addition': [2623, 2806, 3955], 'during': [2629], 'enzymatic': [2630], 'cleavage': [2631], 'yields': [2632], 'species': [2636], 'thus': [2638], 'distinguishes': [2639], 'C': [2643, 2823, 2980, 3851], 'terminus': [2644, 2650], 'those': [2646, 3323], 'N': [2649, 2842, 3853], 'their': [2652, 3449], 'distinctive': [2653], 'patterns': [2655], 'fragments,': [2751], 'each': [2752], 'observed': [2754, 3008, 3024, 3050], 'selected': [2758], 'turn': [2760], 'parent': [2763, 2794, 2976], 'mass-selecting': [2766], 'QqTOF': [2770], 'instrument': [2771], 'subjected': [2773], 'collisionally': [2775], 'induced': [2776], 'dissociation': [2777, 2930], 'collision': [2780], 'cell.': [2781], 'daughter': [2786, 2927], '=': [2792], '2297': [2793], '3,': [2799], 'where': [2800], 'advantages': [2802], '16O/18O': [2805], 'distinguishing': [2808], 'C-': [2810], 'N-terminal': [2812, 2934, 2940, 2947, 3863, 3878, 3886], 'evident.': [2816], 'ions,': [2819, 2839], 'which': [2820, 3917, 4028, 4060, 4107], 'contain': [2821, 4061], 'terminus,': [2824, 2843, 2981], 'show': [2826], 'doublet': [2828, 2989], 'structure': [2829], 'superimposed': [2830], 'usual': [2833], 'pattern,': [2835], 'whereas': [2836], 'b': [2838, 2873], 'normal': [2846], 'pattern.': [2847], 'comparison': [2849, 2953, 2992, 3823], 'measured': [2852, 2870], 'values': [2854, 2996, 3026, 3049, 3070, 3265], 'masses': [2857, 2871, 2998, 3029], 'calculated': [2858, 2999, 3030, 3068, 3082], 'deduced': [2861, 3002, 3033], 'given': [2864, 3013, 4046], 'Table': [2866, 3015, 3056, 3124, 3426, 3820, 4048], 'I.Table': [2867], 'ICalculated': [2868], 'measurements': [2879, 3105, 3404, 3488], '2297.092-Da': [2882], 'fragmenty-ionm/z': [2884], 'foundMH+': [2885, 2889], 'calculatedΔm': [2886], '(mDa)ResidueΔm': [2887], '(mDa)m/z': [2888], 'calculatedb-ion': [2890], 'y1–147.113–K22279.0832279.081b20': [2891], 'y2261.138261.156−18N––2150.986b19': [2892], 'y3332.193332.1930A––2036.943b18': [2893], 'y4389.197389.215−18G––1965.906b17': [2894], 'y5552.283552.2785Y01908.8851908.885b16': [2895], 'y6649.328649.331−3P−131745.8091745.822b15': [2896], 'y7762.413762.415−2L211648.7901648.769b14': [2897], 'y8849.438849.447−9S81535.6941535.685b13': [2898], 'y9920.478920.484−6A−151448.6381448.653b12y101049.5221049.526−4E191377.6371377.616b11y111146.5711146.579−8P––1248.573b10y121203.5921203.601−9G−41151.5161151.520': [2899], 'b9y131304.6361304.648−8T−51094.4941094.499': [2900], 'b8y141361.6541361.670−16G1993.452993.451': [2901], 'b7y151474.7391474.754−15L−21936.409936.430': [2902], 'b6y161637.8181637.8171Y11823.357823.346': [2903], 'b5y171800.8841800.8813Y9660.291660.282': [2904], 'b4y181947.9701947.94921F1497.220497.219': [2905], 'b3y192111.0222111.01210Y−5350.145350.150': [2906], 'b2y202297.0862297.092−6W––187.087': [2907], 'b1': [2908], 'Open': [2909, 3095], 'table': [2910, 3096], 'tab': [2914, 3100], 'Further': [2915], 'examples': [2916], 'provided': [2918, 3227], 'supplemental': [2921], 'material.': [2922], 'S1': [2924], '1144-Da': [2933], 'peptide,': [2935], 'indicating': [2936], 'deletion': [2937, 3887], 'methionine': [2941, 3864], 'acetylation': [2943, 3874, 3889], 'serine.': [2948], 'S2': [2950], 'HPLC-separated': [2955], 'digestions,': [2961], 'respectively,': [2962], 'showing': [2963], 'alternate': [2964], 'cleavages': [2965], 'adjacent': [2967], 'lysines.': [2968], 'S3': [2970], 'C-terminal': [2984], 'no': [2988], 'structure.': [2990], 'experimental': [2994], 'sequences': [3003, 3036], 'II.': [3016, 3427, 3821], 'Tables': [3019], 'I': [3020, 3057], 'II,': [3022], 'agree': [3037, 3349], 'mDa,': [3040], 'lending': [3041], 'credibility': [3042], 'assignments;': [3045], 'anomalously': [3047], 'correspond': [3058], 'very': [3062, 3973], 'low': [3063, 3991], 'intensity.Table': [3064], 'IIMeasured': [3065], 'MH+': [3069], '46-kDa': [3079], 'proteinm/z': [3080], 'measuredMH+': [3081], '(Da)Δm': [3083], '(mDa)Residues': [3084], 'start-endPeptide': [3085], 'sequence601.303601.305−3204–209GNSPAR601.322601.3311103–107ELSPR698.357698.358−1144–149DHIGTR708.330708.335−5': [3086], '96–102GGDGKM*K711.333711.3312294–299QGTDYK746.387746.3834356–361HIDAYK': [3087], '749.354749.3540178–185GGSQASSR805.378805.380−2196–203NSTPGSSR831.462831.4575227–233LNQLESK876.452876.461−9101–107M*KELSPR886.401886.406−5170–177GFYAEGSR916.478916.4780362–369TFPPTEPK928.543928.546−3348–355DNVILLNK946.513946.5112': [3088], '62–68EELRFPR1105.5481105.553−5339–347LDDKDPQFK1144.4931144.499−61–10Ac-SDNGPQSNQR1154.5791154.580−1376–385TDEAQPLPQR1166.5571166.559−2267–276Q**YNVTQAFGR1183.5891183.5863267–276QYNVTQAFGR1202.6101202.613−3238–248GQQQQGQTVTK1282.6781282.6753375–385KTDEAQPLPQR1330.6981330.708−10238–249GQQQQGQTVTKK1410.7741410.7713376–387KKTDEAQPLPQR1611.6981611.6926406–421QLQNSM*SGASADSTQA1684.8951684.8914128–143EGIVWVATEGALNTPK1687.8981687.905−7210–226MASGGGETALALLLLDR1703.8971703.900−3210–226M*ASGGGETALALLLLDR1774.8381774.8362278–293GPEQTQGNFGDQDLIR1850.8331850.8276': [3089], '15–32ITFGGPTDSTDNNQNGGR1851.8141850.8113': [3090], '15–32ITFGGPTDSTDNNQN***GGR1875.8791875.8790389–405Q**PTVTLLPAADM*DDFSR1892.9051892.906−1389–405QPTVTLLPAADM*DDFSR1930.9441930.9377277–293RGPEQTQGNFGDQDLIR2005.0082005.0062388–405KQPTVTLLPAADMDDFSR2015.0812015.0810339–355LDDKDPQFKDNVILLNK2021.0052021.0014388–405KQPTVTLLPAADM*DDFSR2077.0482077.0435320–338IGM*EVTPSGTWLTYHGAIK2091.1262091.120−2150–169NPNNNAATVLQLPQGTTLPK2151.0022151.0106': [3091], '69–88GQGVPINTNSGPDDQIGYYR2252.0622252.071−9300–319HWPQIAQFAPSASAFFGMSR2297.0782297.092−14108–127WYFYYLGTGPEASLPYGANK2307.1282307.11117': [3092], '69–89GQGVPINTNSGPDDQIGYYRR2324.1872324.190−3': [3093], '41–61RPQGLPNNTASWFTALTQHGK2516.3252516.339−14210–233M*ASGGGETALALLLLDRLNQLESK': [3094], 'just': [3106], 'applied': [3109], 'band,': [3121], 'listed': [3122, 3818], 'I,': [3125], 'products': [3130], 'BLAST': [3135, 3150, 3195, 3242, 3257, 3275, 3326, 3369, 3800], '(20Altschul': [3137], 'S.F.': [3138], 'Stephen': [3139], 'Madden': [3141], 'Zhang': [3143], 'Schaeffer': [3144], 'Miller': [3145], 'J.W.': [3146], 'Lipman': [3147], 'D.J.': [3148], 'Gapped': [3149], 'PSI-BLAST:': [3152], 'generation': [3155], 'database': [3158], 'search': [3159, 3219, 3243, 3276], 'programs.Nucleic': [3160], 'Acids': [3161], '25:': [3164], '3389-3402Google': [3165], '21Shevchenko': [3167], 'Sunyaev': [3171], 'Bork': [3175], 'Charting': [3181], 'proteomes': [3183], 'organisms': [3185], 'unsequenced': [3187], 'genomes': [3188], 'MALDI-quadrupole': [3190], 'homology': [3196, 3801], 'searching.Anal.': [3197], '73:': [3200], '1917-1926Google': [3201], 'total': [3205], 'GenBank™': [3206], 'homology.': [3221], 'definitive': [3224], 'example': [3225, 3667], '2297-Da': [3230], 'peptide.': [3232], 'case,': [3235], 'highest': [3237, 3270], 'rated': [3238, 3271], '4;': [3248], 'proteins,': [3253], 'scores': [3258], '41,': [3262], 'E': [3264, 3298], '0.003.': [3267], 'Moreover,': [3268], 'hit': [3272], 'not': [3279, 3436, 3465, 3921, 4129], 'protein,': [3285, 3962, 4139], 'case)': [3288], 'score': [3291], '29': [3294], 'value': [3299], '9.4.': [3301], 'protein;': [3311], 'indeed,': [3312], 'there': [3313, 3441], 'agreement': [3316], '10': [3320], 'highly': [3335], 'conserved.': [3336], 'On': [3337], 'hand,': [3340], 'out': [3343, 3408, 3453, 3463, 3490], 'next': [3346], 'nine': [3347], 'viruses,': [3355], 'significantly': [3361], 'coronaviruses.': [3368], 'searches': [3370], 'led': [3375], 'conclusions;': [3378], 'they': [3381, 4073], 'strengthened': [3382], 'differences': [3387], 'base.': [3399], 'By': [3400], 'April': [3401], '12,': [3402], 'carried': [3407, 3462], 'them': [3412], 'analyzed,': [3413], 'yielding': [3414], 'information': [3418], 'peptides,': [3422], 'summarized': [3424], 'task': [3429], 'fitting': [3431], 'yet': [3437, 3466], 'done,': [3438], 'however,': [3439], 'still': [3443], 'number': [3445, 3654, 3937, 4016, 4064], 'ambiguities': [3447, 3812], 'order.': [3450], 'To': [3451, 4133], 'sort': [3452], 'problem,': [3455], '(but': [3464], 'HPLC),': [3470], 'Glu-C': [3472], 'Arg-C': [3475], 'planned': [3478], 'sufficient': [3482], 'available.': [3485], 'However,': [3486], 'turned': [3489], 'unnecessary,': [3493], 'stage': [3497], '(also': [3504], 'NML),': [3507], 'group': [3512, 3771], 'Michael': [3515], 'Smith': [3516], 'Genome': [3517], 'Vancouver': [3520, 3770], '(GenBank™': [3652, 3935, 4014], 'accession': [3653, 3936, 4015], 'AY274119),': [3655, 3938, 4017], 'followed': [3657], '(see': [3665], 'us': [3761], 'specifying': [3773], 'did': [3778], 'fact': [3780], 'predict': [3781], 'analyzing,': [3793], 'might': [3795], 'expected': [3797], 'reported': [3802], 'above.': [3803, 4154], 'Consequently,': [3804], 'able': [3807], 'ordering': [3814], 'our': [3825, 3929], 'S4A;': [3835], 'spectral': [3838], 'cover': [3840], 'than': [3842], '96%': [3843], 'termini.': [3854], 'indicate': [3859], 'removal': [3860], 'oxidation': [3866], 'methionines,': [3870], 'well': [3872], 'serine,': [3879], 'S1.': [3884, 4049], 'presumably': [3890], 'occur': [3891], 'post-translational': [3896], 'modifications': [3897], '(22Krishna': [3898], 'Wold': [3900], 'Posttranslational': [3902], 'modifications.in:': [3903], 'Angeletti': [3904], 'R.H.': [3905], 'Proteins—Analysis': [3906], 'Design.': [3908], 'Elsevier,': [3909], 'Academic': [3910], 'Press,': [3911], 'San': [3912], 'Diego,': [3913], 'CA1998:': [3914], '121-206Google': [3915], 'course': [3919], 'could': [3920], 'Otherwise,': [3928], 'confirm': [3931], 'consistent': [3941], 'being': [3945], 'derived': [3946], 'source': [3951], 'NML.': [3953], 'completely': [3959], 'partially': [3965], 'characterized': [3966], 'appeared': [3970], 'weak': [3974], 'kDa': [3982], 'separation': [3986], 'Despite': [3989], 'intensity,': [3992], '39': [3993], 'initial': [3997], 'belong': [4003], '"spike': [4007], 'protein"': [4008], '36': [4019], 'sufficiently': [4023], '(30%': [4032], 'summary': [4035], 'coverage': [4041], 'homologous': [4053], 'coronaviruses,': [4059], 'potential': [4066, 4103], '(NXT': [4069], 'NXS).': [4071], 'usually': [4075], 'assumed': [4076], 'act': [4083], 'attachment': [4085], 'Indeed,': [4087], 'contains': [4099], '23': [4100], 'N-glycosylation': [4104], 'sites,': [4105], '17': [4108], 'likely': [4112], 'Netglyc': [4116], '1.0': [4117], 'server': [4118], '(available': [4119], 'www.cbs.dtu.dk/services/NetNGlyc).': [4121], '(O-glycosylation': [4122], 'possible,': [4126], 'here.)': [4132], 'investigate': [4134], 'treated': [4144], 'PNGase': [4146], 'glycans,': [4151], 'step': [4156], 'converts': [4157], 'asparagine': [4158]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2137976135', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 4}, {'year': 2022, 'cited_by_count': 13}, {'year': 2021, 'cited_by_count': 17}, {'year': 2020, 'cited_by_count': 19}, {'year': 2019, 'cited_by_count': 5}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 1}, {'year': 2015, 'cited_by_count': 5}, {'year': 2014, 'cited_by_count': 2}, {'year': 2013, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 4}], 'updated_date': '2024-12-24T13:47:01.088541', 'created_date': '2016-06-24'}
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