Title: Interaction between Platinum Complexes and a Methionine Motif Found in Copper Transport Proteins
Abstract: Angewandte Chemie International EditionVolume 46, Issue 47 p. 9062-9064 Communication Interaction between Platinum Complexes and a Methionine Motif Found in Copper Transport Proteins† Fabio Arnesano Dr., Fabio Arnesano Dr. Dipartimento Farmaco-Chimico, University of Bari, Via E. Orabona 4, 70125 Bari, Italy, Fax: (+39) 080-544-2230Search for more papers by this authorSimone Scintilla, Simone Scintilla Dipartimento Farmaco-Chimico, University of Bari, Via E. Orabona 4, 70125 Bari, Italy, Fax: (+39) 080-544-2230Search for more papers by this authorGiovanni Natile Prof., Giovanni Natile Prof. [email protected] Dipartimento Farmaco-Chimico, University of Bari, Via E. Orabona 4, 70125 Bari, Italy, Fax: (+39) 080-544-2230Search for more papers by this author Fabio Arnesano Dr., Fabio Arnesano Dr. Dipartimento Farmaco-Chimico, University of Bari, Via E. Orabona 4, 70125 Bari, Italy, Fax: (+39) 080-544-2230Search for more papers by this authorSimone Scintilla, Simone Scintilla Dipartimento Farmaco-Chimico, University of Bari, Via E. Orabona 4, 70125 Bari, Italy, Fax: (+39) 080-544-2230Search for more papers by this authorGiovanni Natile Prof., Giovanni Natile Prof. [email protected] Dipartimento Farmaco-Chimico, University of Bari, Via E. Orabona 4, 70125 Bari, Italy, Fax: (+39) 080-544-2230Search for more papers by this author First published: 23 November 2007 https://doi.org/10.1002/anie.200703271Citations: 80 † We thank Dr. F. P. Intini for providing 15N-labeled cis-DDP and trans-DDP, Dr. C. R. Barone and Prof. L. Maresca for providing the Zeise's salt, and G. Di Pinto for recording mass spectra. We thank the University of Bari, the Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici (CIRCMSB), the Italian Ministero dell'Università e della Ricerca (PRIN 2005 032730), and the European Commission (COST Action D39) for support. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Going to the Mets: The uptake of Pt anticancer drugs also involves the Cu transporter Ctr1, which is located on the plasma membrane and contains functionally essential methionine-rich motifs. The methionine-rich peptide Mets7 reacts readily with PtII species. A striking difference between cis- and trans-[PtCl2(NH3)2] is that, upon reaction with Mets7, only the latter retains its N-donor ligands. Delivery of undegraded Pt drug to intracellular organelles by vesicle trafficking is hypothesized. Citing Literature Supporting Information Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z703271_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume46, Issue47December 3, 2007Pages 9062-9064 RelatedInformation
Publication Year: 2007
Publication Date: 2007-11-23
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
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Cited By Count: 100
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