The Tuberculosis Drug Streptomycin as a Potential Cancer Therapeutic: Inhibition of miR‐21 Function by Directly Targeting Its Precursor

Name: Work Video:
Duration: 3 min 30 s
Description: No dice: MicroRNAs (miRNAs) fine-tune gene expression, deregulation of which has been causally associated with a number of debilitating conditions. Streptomycin, a well-known aminoglycoside drug, binds to RNA secondary structures and is shown to inhibit miR-21 function by direct binding to its precursor, thus presumably interfering with the processing by the Dicer enzyme (see scheme).
Debojit Bose; Gopal Gunanathan Jayaraj; Hemant Suryawanshi; Prachi Agarwala; Subrata K. Pore; Rintu Banerjee‬‬‬‬‬‬‬‬‬; Souvik Maiti
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