The Molecular Receptive Ranges of Human TAS2R Bitter Taste Receptors

Name: Work Video:
Duration: 3 min 30 s
Wolfgang Meyerhof; Claudia Batram; Christina Kühn; Anne Brockhoff; Elke Chudoba; Bernd Bufe; Giovanni Appendino; Maik Behrens
{'id': 'https://openalex.org/W2137311570', 'doi': 'https://doi.org/10.1093/chemse/bjp092', 'title': 'The Molecular Receptive Ranges of Human TAS2R Bitter Taste Receptors', 'display_name': 'The Molecular Receptive Ranges of Human TAS2R Bitter Taste Receptors', 'publication_year': 2009, 'publication_date': '2009-12-18', 'ids': {'openalex': 'https://openalex.org/W2137311570', 'doi': 'https://doi.org/10.1093/chemse/bjp092', 'mag': '2137311570', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/20022913'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/chemse/bjp092', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S8722945', 'display_name': 'Chemical Senses', 'issn_l': '0379-864X', 'issn': ['0379-864X', '1464-3553'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://doi.org/10.1093/chemse/bjp092', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5009872018', 'display_name': 'Wolfgang Meyerhof', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210162705', 'display_name': 'German Institute of Human Nutrition', 'ror': 'https://ror.org/05xdczy51', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I315704651', 'https://openalex.org/I4210162705']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Wolfgang Meyerhof', 'raw_affiliation_strings': ['Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany', 'institution_ids': ['https://openalex.org/I4210162705']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046738312', 'display_name': 'Claudia Batram', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210162705', 'display_name': 'German Institute of Human Nutrition', 'ror': 'https://ror.org/05xdczy51', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I315704651', 'https://openalex.org/I4210162705']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Claudia Batram', 'raw_affiliation_strings': ['Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany', 'institution_ids': ['https://openalex.org/I4210162705']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047035598', 'display_name': 'Christina Kühn', 'orcid': 'https://orcid.org/0000-0002-8370-9706'}, 'institutions': [{'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I4210162705', 'display_name': 'German Institute of Human Nutrition', 'ror': 'https://ror.org/05xdczy51', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I315704651', 'https://openalex.org/I4210162705']}, {'id': 'https://openalex.org/I4210088259', 'display_name': 'National Institute of Dental and Craniofacial Research', 'ror': 'https://ror.org/004a2wv92', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210088259']}], 'countries': ['DE', 'US'], 'is_corresponding': False, 'raw_author_name': 'Christina Kuhn', 'raw_affiliation_strings': ['Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany', 'Present address: National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA'], 'affiliations': [{'raw_affiliation_string': 'Present address: National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA', 'institution_ids': ['https://openalex.org/I1299303238', 'https://openalex.org/I4210088259']}, {'raw_affiliation_string': 'Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany', 'institution_ids': ['https://openalex.org/I4210162705']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076819232', 'display_name': 'Anne Brockhoff', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210162705', 'display_name': 'German Institute of Human Nutrition', 'ror': 'https://ror.org/05xdczy51', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I315704651', 'https://openalex.org/I4210162705']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Anne Brockhoff', 'raw_affiliation_strings': ['Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany', 'institution_ids': ['https://openalex.org/I4210162705']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053723506', 'display_name': 'Elke Chudoba', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210162705', 'display_name': 'German Institute of Human Nutrition', 'ror': 'https://ror.org/05xdczy51', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I315704651', 'https://openalex.org/I4210162705']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Elke Chudoba', 'raw_affiliation_strings': ['Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany', 'institution_ids': ['https://openalex.org/I4210162705']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066671595', 'display_name': 'Bernd Bufe', 'orcid': 'https://orcid.org/0000-0003-1610-0658'}, 'institutions': [{'id': 'https://openalex.org/I4210162705', 'display_name': 'German Institute of Human Nutrition', 'ror': 'https://ror.org/05xdczy51', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I315704651', 'https://openalex.org/I4210162705']}, {'id': 'https://openalex.org/I91712215', 'display_name': 'Saarland University', 'ror': 'https://ror.org/01jdpyv68', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I91712215']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Bernd Bufe', 'raw_affiliation_strings': ['Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany', 'Present address: Department of Physiology Building 58, University of Saarland, Medical Campus, 66421 Homburg/Saar, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany', 'institution_ids': ['https://openalex.org/I4210162705']}, {'raw_affiliation_string': 'Present address: Department of Physiology Building 58, University of Saarland, Medical Campus, 66421 Homburg/Saar, Germany', 'institution_ids': ['https://openalex.org/I91712215']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033662911', 'display_name': 'Giovanni Appendino', 'orcid': 'https://orcid.org/0000-0002-4170-9919'}, 'institutions': [{'id': 'https://openalex.org/I123338534', 'display_name': 'Università degli Studi del Piemonte Orientale “Amedeo Avogadro”', 'ror': 'https://ror.org/04387x656', 'country_code': 'IT', 'type': 'education', 'lineage': ['https://openalex.org/I123338534']}], 'countries': ['IT'], 'is_corresponding': False, 'raw_author_name': 'Giovanni Appendino', 'raw_affiliation_strings': ['Università del Piemonte Orientale, DISCAFF, Via Bovio 6, 28100 Novara, Italy'], 'affiliations': [{'raw_affiliation_string': 'Università del Piemonte Orientale, DISCAFF, Via Bovio 6, 28100 Novara, Italy', 'institution_ids': ['https://openalex.org/I123338534']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5024990714', 'display_name': 'Maik Behrens', 'orcid': 'https://orcid.org/0000-0003-2082-8860'}, 'institutions': [{'id': 'https://openalex.org/I4210162705', 'display_name': 'German Institute of Human Nutrition', 'ror': 'https://ror.org/05xdczy51', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I315704651', 'https://openalex.org/I4210162705']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Maik Behrens', 'raw_affiliation_strings': ['Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany', 'institution_ids': ['https://openalex.org/I4210162705']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3953, 'currency': 'USD', 'value_usd': 3953, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 27.532, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 1002, 'citation_normalized_percentile': {'value': 0.934622, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '35', 'issue': '2', 'first_page': '157', 'last_page': '170'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11584', 'display_name': 'Biochemical Analysis and Sensing Techniques', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11584', 'display_name': 'Biochemical Analysis and Sensing Techniques', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10971', 'display_name': 'Olfactory and Sensory Function Studies', 'score': 0.9912, 'subfield': {'id': 'https://openalex.org/subfields/2809', 'display_name': 'Sensory Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11667', 'display_name': 'Advanced Chemical Sensor Technologies', 'score': 0.9901, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/taste-receptor', 'display_name': 'Taste receptor', 'score': 0.6435651}, {'id': 'https://openalex.org/keywords/gpr120', 'display_name': 'GPR120', 'score': 0.6194877}, {'id': 'https://openalex.org/keywords/bitter-taste', 'display_name': 'Bitter Taste', 'score': 0.5361379}], 'concepts': [{'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.8729463}, {'id': 'https://openalex.org/C8868529', 'wikidata': 'https://www.wikidata.org/wiki/Q124794', 'display_name': 'Taste', 'level': 2, 'score': 0.7144619}, {'id': 'https://openalex.org/C178006227', 'wikidata': 'https://www.wikidata.org/wiki/Q3454532', 'display_name': 'Taste receptor', 'level': 3, 'score': 0.6435651}, {'id': 'https://openalex.org/C19841687', 'wikidata': 'https://www.wikidata.org/wiki/Q18055224', 'display_name': 'GPR120', 'level': 4, 'score': 0.6194877}, {'id': 'https://openalex.org/C135285700', 'wikidata': 'https://www.wikidata.org/wiki/Q38173', 'display_name': 'G protein-coupled receptor', 'level': 3, 'score': 0.5802696}, {'id': 'https://openalex.org/C3020017864', 'wikidata': 'https://www.wikidata.org/wiki/Q124794', 'display_name': 'Bitter taste', 'level': 3, 'score': 0.5361379}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.43014103}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4068422}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.38068092}], 'mesh': [{'descriptor_ui': 'D043562', 'descriptor_name': 'Receptors, G-Protein-Coupled', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013649', 'descriptor_name': 'Taste', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': True}, {'descriptor_ui': 'D000814', 'descriptor_name': 'Aniline Compounds', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D000814', 'descriptor_name': 'Aniline Compounds', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020013', 'descriptor_name': 'Calcium Signaling', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D020013', 'descriptor_name': 'Calcium Signaling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005456', 'descriptor_name': 'Fluorescent Dyes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005456', 'descriptor_name': 'Fluorescent Dyes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D043562', 'descriptor_name': 'Receptors, G-Protein-Coupled', 'qualifier_ui': 'Q000819', 'qualifier_name': 'agonists', 'is_major_topic': False}, {'descriptor_ui': 'D043562', 'descriptor_name': 'Receptors, G-Protein-Coupled', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013649', 'descriptor_name': 'Taste', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D013649', 'descriptor_name': 'Taste', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013652', 'descriptor_name': 'Taste Threshold', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014966', 'descriptor_name': 'Xanthenes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014966', 'descriptor_name': 'Xanthenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/chemse/bjp092', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S8722945', 'display_name': 'Chemical Senses', 'issn_l': '0379-864X', 'issn': ['0379-864X', '1464-3553'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/20022913', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1093/chemse/bjp092', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S8722945', 'display_name': 'Chemical Senses', 'issn_l': '0379-864X', 'issn': ['0379-864X', '1464-3553'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 67, 'referenced_works': ['https://openalex.org/W10263192', 'https://openalex.org/W103160041', 'https://openalex.org/W1496676716', 'https://openalex.org/W150386553', 'https://openalex.org/W1614085367', 'https://openalex.org/W1793017430', 'https://openalex.org/W1964468911', 'https://openalex.org/W1966297508', 'https://openalex.org/W1973693850', 'https://openalex.org/W1978021178', 'https://openalex.org/W1978746486', 'https://openalex.org/W1980409809', 'https://openalex.org/W1983108533', 'https://openalex.org/W1983393161', 'https://openalex.org/W1985101496', 'https://openalex.org/W1988225036', 'https://openalex.org/W1991550423', 'https://openalex.org/W1993003691', 'https://openalex.org/W2006376163', 'https://openalex.org/W2012800318', 'https://openalex.org/W2015171742', 'https://openalex.org/W2017621012', 'https://openalex.org/W2030769846', 'https://openalex.org/W2034618702', 'https://openalex.org/W2037591739', 'https://openalex.org/W2038573621', 'https://openalex.org/W2045358393', 'https://openalex.org/W2051825345', 'https://openalex.org/W2062801880', 'https://openalex.org/W2064034213', 'https://openalex.org/W2066381476', 'https://openalex.org/W2071008461', 'https://openalex.org/W2071196106', 'https://openalex.org/W2076112995', 'https://openalex.org/W2077947269', 'https://openalex.org/W2079375209', 'https://openalex.org/W2080875376', 'https://openalex.org/W2082269792', 'https://openalex.org/W2089885047', 'https://openalex.org/W2091838939', 'https://openalex.org/W2098261065', 'https://openalex.org/W2098729010', 'https://openalex.org/W2098880114', 'https://openalex.org/W2099060512', 'https://openalex.org/W2104321757', 'https://openalex.org/W2109159205', 'https://openalex.org/W2110147039', 'https://openalex.org/W2112671819', 'https://openalex.org/W2114498489', 'https://openalex.org/W2114531054', 'https://openalex.org/W2118311495', 'https://openalex.org/W2118693887', 'https://openalex.org/W2121145363', 'https://openalex.org/W2126098900', 'https://openalex.org/W2126841892', 'https://openalex.org/W2138727998', 'https://openalex.org/W2139177655', 'https://openalex.org/W2139752415', 'https://openalex.org/W2150100375', 'https://openalex.org/W2159413546', 'https://openalex.org/W2161659751', 'https://openalex.org/W2164221127', 'https://openalex.org/W2169702025', 'https://openalex.org/W2345849542', 'https://openalex.org/W2502834717', 'https://openalex.org/W2774304932', 'https://openalex.org/W4214642236'], 'related_works': ['https://openalex.org/W4303961849', 'https://openalex.org/W3164245177', 'https://openalex.org/W2978452059', 'https://openalex.org/W2808796325', 'https://openalex.org/W2784542306', 'https://openalex.org/W2485236155', 'https://openalex.org/W2156849060', 'https://openalex.org/W2007406019', 'https://openalex.org/W1596800225', 'https://openalex.org/W10263192'], 'abstract_inverted_index': {'Humans': [0], 'perceive': [1], 'thousands': [2], 'of': [3, 31, 42, 110, 136, 148], 'compounds': [4, 33, 72, 80, 124], 'as': [5, 25], 'bitter.': [6], 'In': [7], 'sharp': [8], 'contrast,': [9], 'only': [10, 91, 120], '∼25': [11], 'taste': [12, 17, 53], '2': [13, 54], 'receptors': [14, 18, 55, 76, 84, 89], '(TAS2R)': [15], 'bitter': [16, 32, 62, 71, 117, 139], 'have': [19, 49], 'been': [20], 'identified,': [21], 'raising': [22], 'the': [23, 28, 111, 134, 137, 144], 'question': [24], 'to': [26, 107, 127, 143], 'how': [27], 'vast': [29], 'array': [30], 'can': [34], 'be': [35], 'detected': [36], 'by': [37], 'such': [38], 'a': [39, 65], 'limited': [40], 'number': [41], 'sensors.': [43], 'To': [44], 'address': [45], 'this': [46], 'issue,': [47], 'we': [48], 'challenged': [50], '25': [51], 'human': [52], '(hTAS2Rs)': [56], 'with': [57], '104': [58], 'natural': [59], 'or': [60, 97], 'synthetic': [61], 'chemicals': [63, 140], 'in': [64], 'heterologous': [66], 'expression': [67], 'system.': [68], 'Thirteen': [69], 'cognate': [70], 'for': [73, 81], '5': [74], 'orphan': [75], 'and': [77], '64': [78], 'new': [79], 'previously': [82], 'identified': [83], 'were': [85, 105], 'discovered.': [86], 'Whereas': [87], 'some': [88], 'recognized': [90], 'few': [92], 'agonists,': [93], 'others': [94], 'displayed': [95], 'moderate': [96], 'extreme': [98], 'tuning': [99], 'broadness.': [100], 'Thus,': [101], '3': [102], 'hTAS2Rs': [103], 'together': [104], 'able': [106], 'detect': [108], '∼50%': [109], 'substances': [112, 118], 'used.': [113], 'Conversely,': [114], 'though': [115], '63': [116], 'activated': [119], '1–3': [121], 'receptors,': [122], '19': [123], 'stimulated': [125], 'up': [126], '15': [128], 'hTAS2Rs.': [129, 149], 'Our': [130], 'data': [131], 'suggest': [132], 'that': [133], 'detection': [135], 'numerous': [138], 'is': [141], 'related': [142], 'molecular': [145], 'receptive': [146], 'ranges': [147]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2137311570', 'counts_by_year': [{'year': 2024, 'cited_by_count': 82}, {'year': 2023, 'cited_by_count': 69}, {'year': 2022, 'cited_by_count': 79}, {'year': 2021, 'cited_by_count': 91}, {'year': 2020, 'cited_by_count': 76}, {'year': 2019, 'cited_by_count': 73}, {'year': 2018, 'cited_by_count': 82}, {'year': 2017, 'cited_by_count': 80}, {'year': 2016, 'cited_by_count': 59}, {'year': 2015, 'cited_by_count': 70}, {'year': 2014, 'cited_by_count': 62}, {'year': 2013, 'cited_by_count': 65}, {'year': 2012, 'cited_by_count': 43}], 'updated_date': '2024-12-23T22:03:42.309443', 'created_date': '2016-06-24'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
