Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production

Name: Work Video:
Duration: 3 min 30 s
Florian L. Müller; Wook Song; Youngmok C. Jang; Yuhong Liu; Marian Sabia; Arlan Richardson; Holly Van Remmen
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[21], 'ROS': [24, 49, 81, 121, 131, 154, 198, 217, 229], 'generation': [25, 50, 199, 226], 'three': [27], 'conditions': [28], 'associated': [29, 68, 143, 178], 'with': [30, 69, 89, 93, 144, 159, 182], 'atrophy:': [32], 'aging,': [34], 'mice': [36, 65, 91, 103, 140], 'lacking': [37], 'CuZn-SOD': [38], '(Sod1(-/-)),': [39], 'and': [40, 66, 114, 141], 'the': [42, 160, 171, 236], 'neurodegenerative': [43], 'disease,': [44], 'amyotrophic': [45], 'lateral': [46], 'sclerosis': [47], '(ALS).': [48], 'mitochondria': [53, 202], 'is': [54, 67, 83, 133, 142, 156], 'nearly': [55, 220], 'threefold': [56], 'higher': [57, 118, 136], '28-': [59], '32-mo-old': [61], 'than': [62, 137], '10-mo-old': [64], '30%': [71], 'loss': [72, 96, 107, 148, 184], 'gastrocnemius': [74], 'mass.': [75, 99, 152], 'In': [76, 123], 'Sod1(-/-)': [77], 'mice,': [78, 130], 'production': [82, 132, 155, 218], 'increased': [84, 219], '>100%': [85], '20-mo': [87], 'compared': [88], '5-mo-old': [90], 'along': [92], '>50%': [95], 'ALS': [100, 126], 'G93A': [101], 'mutant': [102, 127], 'show': [104], '75%': [106], 'of': [108, 162, 170, 173, 185, 227], 'mass': [110], 'during': [111], 'disease': [112], 'progression': [113], 'up': [115], '12-fold': [117], 'generation.': [122], 'second': [125], 'model,': [128], 'H46RH48Q': [129], 'approximately': [134], 'fourfold': [135], 'control': [139], 'less': [146], '(30%)': [149], 'Thus': [153], 'strongly': [157], 'correlated': [158], 'extent': [161], 'atrophy': [164, 175], 'these': [166], 'models.': [167], 'Because': [168], 'each': [169], 'models': [172], 'studied': [176], 'some': [180], 'degree': [181], 'innervation,': [186], 'we': [187], 'were': [188], 'interested': [189], 'determining': [191], 'whether': [192], 'denervation': [193], 'plays': [194], 'isolated': [203], 'from': [204], 'hindlimb': [205], 'following': [207], 'surgical': [208], 'sciatic': [209], 'nerve': [210], 'transection.': [211], 'Seven': [212], 'days': [213], 'post-denervation,': [214], '30-fold.': [221], 'conclude': [223], 'that': [224], 'enhanced': [225], 'may': [230], 'be': [231], 'common': [233], 'factor': [234], 'mechanism': [237], 'underlying': [238], 'denervation-induced': [239]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2137182040', 'counts_by_year': [{'year': 2024, 'cited_by_count': 12}, {'year': 2023, 'cited_by_count': 16}, {'year': 2022, 'cited_by_count': 34}, {'year': 2021, 'cited_by_count': 24}, {'year': 2020, 'cited_by_count': 30}, {'year': 2019, 'cited_by_count': 22}, {'year': 2018, 'cited_by_count': 25}, {'year': 2017, 'cited_by_count': 17}, {'year': 2016, 'cited_by_count': 27}, {'year': 2015, 'cited_by_count': 18}, {'year': 2014, 'cited_by_count': 13}, {'year': 2013, 'cited_by_count': 21}, {'year': 2012, 'cited_by_count': 16}], 'updated_date': '2024-12-13T17:52:55.940171', 'created_date': '2016-06-24'}
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