Publication Information

{'id': 'https://openalex.org/W2137109532', 'doi': 'https://doi.org/10.1128/mcb.24.15.6837-6849.2004', 'title': 'Gene Expression Analysis of Tumor Spheroids Reveals a Role for Suppressed DNA Mismatch Repair in Multicellular Resistance to Alkylating Agents', 'display_name': 'Gene Expression Analysis of Tumor Spheroids Reveals a Role for Suppressed DNA Mismatch Repair in Multicellular Resistance to Alkylating Agents', 'publication_year': 2004, 'publication_date': '2004-07-14', 'ids': {'openalex': 'https://openalex.org/W2137109532', 'doi': 'https://doi.org/10.1128/mcb.24.15.6837-6849.2004', 'mag': '2137109532', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15254249', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/444854'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/mcb.24.15.6837-6849.2004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S81455967', 'display_name': 'Molecular and Cellular Biology', 'issn_l': '0270-7306', 'issn': ['0270-7306', '1067-8824', '1098-5549'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://doi.org/10.1128/mcb.24.15.6837-6849.2004', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5075999310', 'display_name': 'Giulio Francia', 'orcid': 'https://orcid.org/0000-0002-3752-3070'}, 'institutions': [{'id': 'https://openalex.org/I1323843004', 'display_name': 'Sunnybrook Health Science Centre', 'ror': 'https://ror.org/03wefcv03', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1323843004']}, {'id': 'https://openalex.org/I2802362269', 'display_name': 'Health Sciences Centre', 'ror': 'https://ror.org/05pr37258', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I110535807', 'https://openalex.org/I2802362269']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Giulio Francia', 'raw_affiliation_strings': ["Molecular and Cellular Biology Research, Sunnybrook and Women's College Health Sciences Centre, S-217 Research Building, 2075 Bayview Ave., Toronto, Ontario, Canada M4N 3M5."], 'affiliations': [{'raw_affiliation_string': "Molecular and Cellular Biology Research, Sunnybrook and Women's College Health Sciences Centre, S-217 Research Building, 2075 Bayview Ave., Toronto, Ontario, Canada M4N 3M5.", 'institution_ids': ['https://openalex.org/I1323843004', 'https://openalex.org/I2802362269']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5108451743', 'display_name': 'Shan Man', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2802362269', 'display_name': 'Health Sciences Centre', 'ror': 'https://ror.org/05pr37258', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I110535807', 'https://openalex.org/I2802362269']}, {'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}, {'id': 'https://openalex.org/I1323843004', 'display_name': 'Sunnybrook Health Science Centre', 'ror': 'https://ror.org/03wefcv03', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1323843004']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Shan Man', 'raw_affiliation_strings': ["Molecular and Cellular Biology Research, Sunnybrook and Women's College Health Sciences Centre, and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada"], 'affiliations': [{'raw_affiliation_string': "Molecular and Cellular Biology Research, Sunnybrook and Women's College Health Sciences Centre, and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada", 'institution_ids': ['https://openalex.org/I2802362269', 'https://openalex.org/I185261750', 'https://openalex.org/I1323843004']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040137655', 'display_name': 'Beverly A. Teicher', 'orcid': 'https://orcid.org/0000-0003-1535-7304'}, 'institutions': [], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Beverly Teicher', 'raw_affiliation_strings': ['Genzyme Corporation, Framingham, Massachusetts'], 'affiliations': [{'raw_affiliation_string': 'Genzyme Corporation, Framingham, Massachusetts', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083015075', 'display_name': 'Luigi Grasso', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210127606', 'display_name': 'Morphotek (United States)', 'ror': 'https://ror.org/02yq5yf84', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210127606']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Luigi Grasso', 'raw_affiliation_strings': ['Morphotek Inc., Exton, Pennsylvania'], 'affiliations': [{'raw_affiliation_string': 'Morphotek Inc., Exton, Pennsylvania', 'institution_ids': ['https://openalex.org/I4210127606']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5010799165', 'display_name': 'Robert S. Kerbel', 'orcid': 'https://orcid.org/0000-0002-6015-2570'}, 'institutions': [{'id': 'https://openalex.org/I2802362269', 'display_name': 'Health Sciences Centre', 'ror': 'https://ror.org/05pr37258', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I110535807', 'https://openalex.org/I2802362269']}, {'id': 'https://openalex.org/I185261750', 'display_name': 'University of Toronto', 'ror': 'https://ror.org/03dbr7087', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I185261750']}, {'id': 'https://openalex.org/I1323843004', 'display_name': 'Sunnybrook Health Science Centre', 'ror': 'https://ror.org/03wefcv03', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1323843004']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Robert S. Kerbel', 'raw_affiliation_strings': ["Molecular and Cellular Biology Research, Sunnybrook and Women's College Health Sciences Centre, and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada"], 'affiliations': [{'raw_affiliation_string': "Molecular and Cellular Biology Research, Sunnybrook and Women's College Health Sciences Centre, and Medical Biophysics, University of Toronto, Toronto, Ontario, Canada", 'institution_ids': ['https://openalex.org/I2802362269', 'https://openalex.org/I185261750', 'https://openalex.org/I1323843004']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 3.429, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 54, 'citation_normalized_percentile': {'value': 0.918218, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 93, 'max': 94}, 'biblio': {'volume': '24', 'issue': '15', 'first_page': '6837', 'last_page': '6849'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11369', 'display_name': 'Genetic factors in colorectal cancer', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11369', 'display_name': 'Genetic factors in colorectal cancer', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11287', 'display_name': 'Cancer Genomics and Diagnostics', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/multicellular-organism', 'display_name': 'Multicellular organism', 'score': 0.62426645}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.9233322}, {'id': 'https://openalex.org/C134935766', 'wikidata': 'https://www.wikidata.org/wiki/Q210538', 'display_name': 'DNA repair', 'level': 3, 'score': 0.66979736}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.62479043}, {'id': 'https://openalex.org/C74318829', 'wikidata': 'https://www.wikidata.org/wiki/Q36458', 'display_name': 'Multicellular organism', 'level': 3, 'score': 0.62426645}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.49330655}, {'id': 'https://openalex.org/C60748783', 'wikidata': 'https://www.wikidata.org/wiki/Q2984243', 'display_name': 'DNA mismatch repair', 'level': 4, 'score': 0.48691857}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.47925687}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.4576011}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.45393905}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.44078684}, {'id': 'https://openalex.org/C102744134', 'wikidata': 'https://www.wikidata.org/wiki/Q22280388', 'display_name': 'Homologous recombination', 'level': 3, 'score': 0.43104827}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.41937137}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.325176}], 'mesh': [{'descriptor_ui': 'D000477', 'descriptor_name': 'Alkylating Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D020137', 'descriptor_name': 'Base Pair Mismatch', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D004260', 'descriptor_name': 'DNA Repair', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D020411', 'descriptor_name': 'Oligonucleotide Array Sequence Analysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D018874', 'descriptor_name': 'Spheroids, Cellular', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000477', 'descriptor_name': 'Alkylating Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001483', 'descriptor_name': 'Base Sequence', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015152', 'descriptor_name': 'Blotting, Northern', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016466', 'descriptor_name': 'CHO Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D002945', 'descriptor_name': 'Cisplatin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006224', 'descriptor_name': 'Cricetinae', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020869', 'descriptor_name': 'Gene Expression Profiling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008957', 'descriptor_name': 'Models, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008969', 'descriptor_name': 'Molecular Sequence Data', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016133', 'descriptor_name': 'Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017434', 'descriptor_name': 'Protein Structure, Tertiary', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012313', 'descriptor_name': 'RNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020133', 'descriptor_name': 'Reverse Transcriptase Polymerase Chain Reaction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017422', 'descriptor_name': 'Sequence Analysis, DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018874', 'descriptor_name': 'Spheroids, Cellular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013997', 'descriptor_name': 'Time Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014407', 'descriptor_name': 'Tumor Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015854', 'descriptor_name': 'Up-Regulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/mcb.24.15.6837-6849.2004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S81455967', 'display_name': 'Molecular and Cellular Biology', 'issn_l': '0270-7306', 'issn': ['0270-7306', '1067-8824', '1098-5549'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc444854', 'pdf_url': 'https://europepmc.org/articles/pmc444854?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC444854', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/15254249', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1128/mcb.24.15.6837-6849.2004', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S81455967', 'display_name': 'Molecular and Cellular Biology', 'issn_l': '0270-7306', 'issn': ['0270-7306', '1067-8824', '1098-5549'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.84}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 46, 'referenced_works': ['https://openalex.org/W1498545903', 'https://openalex.org/W1532843102', 'https://openalex.org/W1591622995', 'https://openalex.org/W1599096704', 'https://openalex.org/W1634946633', 'https://openalex.org/W1694536435', 'https://openalex.org/W1924355940', 'https://openalex.org/W1977492313', 'https://openalex.org/W1978368163', 'https://openalex.org/W1982640212', 'https://openalex.org/W1983075270', 'https://openalex.org/W1989494625', 'https://openalex.org/W1997241897', 'https://openalex.org/W2006211525', 'https://openalex.org/W2012071848', 'https://openalex.org/W2020039707', 'https://openalex.org/W2023027189', 'https://openalex.org/W2023052504', 'https://openalex.org/W2023062664', 'https://openalex.org/W2023300542', 'https://openalex.org/W2030686317', 'https://openalex.org/W2036571761', 'https://openalex.org/W2041585886', 'https://openalex.org/W2051703027', 'https://openalex.org/W2062120717', 'https://openalex.org/W2067028787', 'https://openalex.org/W2089183849', 'https://openalex.org/W2089687291', 'https://openalex.org/W2096551220', 'https://openalex.org/W2101863911', 'https://openalex.org/W2107268270', 'https://openalex.org/W2110048188', 'https://openalex.org/W2113832454', 'https://openalex.org/W2114354954', 'https://openalex.org/W2124253218', 'https://openalex.org/W2129066173', 'https://openalex.org/W2138351184', 'https://openalex.org/W2152326461', 'https://openalex.org/W2163344131', 'https://openalex.org/W2279816465', 'https://openalex.org/W2435167068', 'https://openalex.org/W26943589', 'https://openalex.org/W2883903927', 'https://openalex.org/W4240331067', 'https://openalex.org/W4253420365', 'https://openalex.org/W632385111'], 'related_works': ['https://openalex.org/W3125757075', 'https://openalex.org/W2760815521', 'https://openalex.org/W2747101336', 'https://openalex.org/W2178875098', 'https://openalex.org/W2108718931', 'https://openalex.org/W2055890925', 'https://openalex.org/W2033918102', 'https://openalex.org/W2004480716', 'https://openalex.org/W1991644354', 'https://openalex.org/W1972094156'], 'abstract_inverted_index': {'Drug': [0], 'resistance': [1, 102, 114, 222, 244], 'is': [2, 18], 'a': [3, 19, 192, 238], 'major': [4], 'obstacle': [5], 'in': [6, 23, 98, 115, 135, 175, 196, 210, 225], 'the': [7, 15, 58, 122, 153, 162, 166, 182], 'successful': [8], 'treatment': [9], 'of': [10, 14, 31, 93, 152, 186, 241, 245], 'cancer.': [11], 'Thus,': [12], 'elucidation': [13], 'mechanisms': [16], 'responsible': [17], 'critical': [20], 'first': [21], 'step': [22], 'trying': [24], 'to': [25, 45, 70, 88, 103, 132, 172, 198, 207, 214, 223, 248], 'prevent': [26], 'or': [27], 'delay': [28], 'such': [29], 'manifestations': [30], 'resistance.': [32], 'In': [33], 'this': [34], 'regard,': [35], 'three-dimensional': [36], 'multicellular': [37, 243], 'tumor': [38, 95, 116, 176, 246], 'cell': [39], 'spheroids': [40, 137, 212], 'are': [41], 'intrinsically': [42], 'more': [43], 'resistant': [44], 'virtually': [46], 'all': [47], 'anticancer': [48], 'cytotoxic': [49], 'drugs': [50], 'than': [51], 'conventional': [52], 'monolayer': [53, 78], 'cultures.': [54], 'We': [55], 'have': [56], 'employed': [57], 'EMT-6': [59, 94, 136, 211, 226], 'subline': [60], 'PC5T,': [61], 'which': [62, 159, 178], 'forms': [63], 'highly': [64], 'compact': [65], 'spheroids,': [66, 177], 'and': [67, 79, 126, 138, 145, 200, 227], 'differential': [68], 'display': [69], 'identify': [71], 'candidate': [72], 'genes': [73, 108, 119], 'whose': [74, 109], 'expression': [75, 110], 'differs': [76], 'between': [77], 'spheroids.': [80, 117], 'Approximately': [81], '5,000': [82], 'bands': [83], 'were': [84, 130, 149], 'analyzed,': [85], 'revealing': [86], '26': [87], 'be': [89, 133, 173, 208], 'differentially': [90], 'expressed.': [91], 'Analysis': [92, 151, 185], 'variants': [96], 'selected': [97], 'vivo': [99], 'for': [100, 194], 'acquired': [101], 'alkylating': [104, 249], 'agents': [105], 'identified': [106], 'eight': [107], 'correlated': [111], 'with': [112, 165], 'drug': [113], 'Four': [118], '(encoding': [120, 140], 'Nop56,': [121], 'NADH': [123], 'SDAP': [124], 'subunit,': [125], 'two': [127, 146], 'novel': [128, 147], 'sequences)': [129, 148], 'found': [131, 206], 'down-regulated': [134, 174], 'four': [139], '2-oxoglutarate': [141], 'carrier': [142], 'protein,': [143], 'JTV-1,': [144], 'up-regulated.': [150], 'DNA': [154, 201, 234], 'mismatch': [155, 202, 235], 'repair-associated': [156], 'PMS2': [157, 170, 195, 218], 'gene,': [158, 168], 'overlaps': [160], 'at': [161, 181], 'genomic': [163], 'level': [164], 'JTV-1': [167], 'revealed': [169], 'mRNA': [171], 'was': [179, 205], 'confirmed': [180, 191], 'protein': [183], 'level.': [184], 'PMS2(-/-)': [187], 'mouse': [188], 'embryo': [189], 'fibroblasts': [190], 'role': [193], 'sensitivity': [197], 'cisplatin,': [199], 'repair': [203, 236], 'activity': [204], 'reduced': [209, 233], 'compared': [213], 'monolayers.': [215], 'Dominant': [216], 'negative': [217], 'transfection': [219], 'caused': [220], 'increased': [221], 'cisplatin': [224], 'CHO': [228], 'cells.': [229], 'Our': [230], 'results': [231], 'implicate': [232], 'as': [237], 'determinant': [239], 'factor': [240], 'reversible': [242], 'cells': [247], 'agents.': [250]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2137109532', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 5}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 3}, {'year': 2014, 'cited_by_count': 4}, {'year': 2013, 'cited_by_count': 3}, {'year': 2012, 'cited_by_count': 2}], 'updated_date': '2024-12-23T01:42:32.172335', 'created_date': '2016-06-24'}