Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2137018402', 'doi': 'https://doi.org/10.1016/j.biotechadv.2011.03.007', 'title': 'Experimental methods and modeling techniques for description of cell population heterogeneity', 'display_name': 'Experimental methods and modeling techniques for description of cell population heterogeneity', 'publication_year': 2011, 'publication_date': '2011-11-01', 'ids': {'openalex': 'https://openalex.org/W2137018402', 'doi': 'https://doi.org/10.1016/j.biotechadv.2011.03.007', 'mag': '2137018402', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/21540103'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.biotechadv.2011.03.007', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S160877137', 'display_name': 'Biotechnology Advances', 'issn_l': '0734-9750', 'issn': ['0734-9750', '1873-1899'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://biblio.ugent.be/publication/1965006/file/1965749', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5045356530', 'display_name': 'Rita Lencastre Fernandes', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'R Lencastre Fernandes', 'raw_affiliation_strings': ['Center for Process Engineering and Technology, Department of Chemical and Biochemical Engineering, Technical University of Denmark, DK 2800 Kgs. Lyngby, Denmark'], 'affiliations': [{'raw_affiliation_string': 'Center for Process Engineering and Technology, Department of Chemical and Biochemical Engineering, Technical University of Denmark, DK 2800 Kgs. Lyngby, Denmark', 'institution_ids': ['https://openalex.org/I96673099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078904263', 'display_name': 'Marta Nierychlo', 'orcid': 'https://orcid.org/0000-0003-1756-3726'}, 'institutions': [{'id': 'https://openalex.org/I891191580', 'display_name': 'Aalborg University', 'ror': 'https://ror.org/04m5j1k67', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I891191580']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'M Nierychlo', 'raw_affiliation_strings': ['Univ Aalborg, Aalborg University, Dept Biotechnol Chem & Environm Engn'], 'affiliations': [{'raw_affiliation_string': 'Univ Aalborg, Aalborg University, Dept Biotechnol Chem & Environm Engn', 'institution_ids': ['https://openalex.org/I891191580']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5047314827', 'display_name': 'Luisa Lundin', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'L Lundin', 'raw_affiliation_strings': ['Univ Copenhagen, University of Copenhagen, Dept Biol, Mol Microbial Ecol Grp'], 'affiliations': [{'raw_affiliation_string': 'Univ Copenhagen, University of Copenhagen, Dept Biol, Mol Microbial Ecol Grp', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103560134', 'display_name': 'AE Pedersen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'AE Pedersen', 'raw_affiliation_strings': ['Tech Univ Denmark, Technical University of Denmark, Dept Syst Biol, Ctr Syst Microbiol'], 'affiliations': [{'raw_affiliation_string': 'Tech Univ Denmark, Technical University of Denmark, Dept Syst Biol, Ctr Syst Microbiol', 'institution_ids': ['https://openalex.org/I96673099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088646235', 'display_name': 'PE Puentes Tellez', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'PE Puentes Tellez', 'raw_affiliation_strings': ['Falcao Salles lab'], 'affiliations': [{'raw_affiliation_string': 'Falcao Salles lab', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101737650', 'display_name': 'Abhishek Dutta', 'orcid': 'https://orcid.org/0000-0002-0714-1119'}, 'institutions': [{'id': 'https://openalex.org/I32597200', 'display_name': 'Ghent University', 'ror': 'https://ror.org/00cv9y106', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I32597200']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Abhishek Dutta', 'raw_affiliation_strings': ['Biomath, Department of Applied Mathematics, Biometrics and Process Control. Ghent University, Coupure links 653, B-9000 Ghent, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Biomath, Department of Applied Mathematics, Biometrics and Process Control. Ghent University, Coupure links 653, B-9000 Ghent, Belgium', 'institution_ids': ['https://openalex.org/I32597200']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008599815', 'display_name': 'Magnus Carlquist', 'orcid': 'https://orcid.org/0000-0001-8881-8197'}, 'institutions': [{'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'M Carlquist', 'raw_affiliation_strings': ['Tech Univ Denmark, Technical University of Denmark, Dept Syst Biol, Ctr Microbial Technol'], 'affiliations': [{'raw_affiliation_string': 'Tech Univ Denmark, Technical University of Denmark, Dept Syst Biol, Ctr Microbial Technol', 'institution_ids': ['https://openalex.org/I96673099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069158890', 'display_name': 'Andrijana Bolic', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'A Bolic', 'raw_affiliation_strings': ['Tech Univ Denmark, Technical University of Denmark, Ctr Proc Engn & Technol, Dept Chem & Biochem Engn'], 'affiliations': [{'raw_affiliation_string': 'Tech Univ Denmark, Technical University of Denmark, Ctr Proc Engn & Technol, Dept Chem & Biochem Engn', 'institution_ids': ['https://openalex.org/I96673099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5063968743', 'display_name': 'Daniel Schäpper', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'D Schäpper', 'raw_affiliation_strings': ['Tech Univ Denmark, Technical University of Denmark, Ctr Proc Engn & Technol, Dept Chem & Biochem Engn'], 'affiliations': [{'raw_affiliation_string': 'Tech Univ Denmark, Technical University of Denmark, Ctr Proc Engn & Technol, Dept Chem & Biochem Engn', 'institution_ids': ['https://openalex.org/I96673099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069530846', 'display_name': 'AC Brunetti', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'AC Brunetti', 'raw_affiliation_strings': ['Tech Univ Denmark, Technical University of Denmark, Dept Photon Engn'], 'affiliations': [{'raw_affiliation_string': 'Tech Univ Denmark, Technical University of Denmark, Dept Photon Engn', 'institution_ids': ['https://openalex.org/I96673099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008071719', 'display_name': 'Søren Helmark', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'S Helmark', 'raw_affiliation_strings': ['Tech Univ Denmark, Technical University of Denmark, Fermenco ApS'], 'affiliations': [{'raw_affiliation_string': 'Tech Univ Denmark, Technical University of Denmark, Fermenco ApS', 'institution_ids': ['https://openalex.org/I96673099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005129322', 'display_name': 'A.L. Heins', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'A-L Heins', 'raw_affiliation_strings': ['Tech Univ Denmark, Technical University of Denmark, Dept Syst Biol, Ctr Microbial Technol'], 'affiliations': [{'raw_affiliation_string': 'Tech Univ Denmark, Technical University of Denmark, Dept Syst Biol, Ctr Microbial Technol', 'institution_ids': ['https://openalex.org/I96673099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053573711', 'display_name': 'Anker Degn Jensen', 'orcid': 'https://orcid.org/0000-0002-7341-4859'}, 'institutions': [{'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'AD Jensen', 'raw_affiliation_strings': ['Tech Univ Denmark, Technical University of Denmark, Ctr Combust & Harmful Emiss Control, Dept Chem & Biochem Engn'], 'affiliations': [{'raw_affiliation_string': 'Tech Univ Denmark, Technical University of Denmark, Ctr Combust & Harmful Emiss Control, Dept Chem & Biochem Engn', 'institution_ids': ['https://openalex.org/I96673099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016991004', 'display_name': 'Ingmar Nopens', 'orcid': 'https://orcid.org/0000-0001-6670-3700'}, 'institutions': [{'id': 'https://openalex.org/I32597200', 'display_name': 'Ghent University', 'ror': 'https://ror.org/00cv9y106', 'country_code': 'BE', 'type': 'education', 'lineage': ['https://openalex.org/I32597200']}], 'countries': ['BE'], 'is_corresponding': False, 'raw_author_name': 'Ingmar Nopens', 'raw_affiliation_strings': ['Biomath, Department of Applied Mathematics, Biometrics and Process Control. Ghent University, Coupure links 653, B-9000 Ghent, Belgium'], 'affiliations': [{'raw_affiliation_string': 'Biomath, Department of Applied Mathematics, Biometrics and Process Control. Ghent University, Coupure links 653, B-9000 Ghent, Belgium', 'institution_ids': ['https://openalex.org/I32597200']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085732645', 'display_name': 'Karsten Rottwitt', 'orcid': 'https://orcid.org/0000-0001-6738-5847'}, 'institutions': [{'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'K Rottwitt', 'raw_affiliation_strings': ['Tech Univ Denmark, Technical University of Denmark, Dept Photon Engn'], 'affiliations': [{'raw_affiliation_string': 'Tech Univ Denmark, Technical University of Denmark, Dept Photon Engn', 'institution_ids': ['https://openalex.org/I96673099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003795307', 'display_name': 'Nicolas Szita', 'orcid': 'https://orcid.org/0000-0002-6204-5074'}, 'institutions': [{'id': 'https://openalex.org/I45129253', 'display_name': 'University College London', 'ror': 'https://ror.org/02jx3x895', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I45129253']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'N Szita', 'raw_affiliation_strings': ['UCL, University College London, University of London, Adv Ctr Biochem Engn, Dept Biochem Engn'], 'affiliations': [{'raw_affiliation_string': 'UCL, University College London, University of London, Adv Ctr Biochem Engn, Dept Biochem Engn', 'institution_ids': ['https://openalex.org/I45129253']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067816863', 'display_name': 'J.D. van Elsas', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210128072', 'display_name': 'ELSA', 'ror': 'https://ror.org/03573dx38', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I4210128072']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'JD van Elsas', 'raw_affiliation_strings': ['Van Elsas lab'], 'affiliations': [{'raw_affiliation_string': 'Van Elsas lab', 'institution_ids': ['https://openalex.org/I4210128072']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5059807847', 'display_name': 'Per Halkjær Nielsen', 'orcid': 'https://orcid.org/0000-0002-6402-1877'}, 'institutions': [{'id': 'https://openalex.org/I891191580', 'display_name': 'Aalborg University', 'ror': 'https://ror.org/04m5j1k67', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I891191580']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'PH Nielsen', 'raw_affiliation_strings': ['Univ Aalborg, Aalborg University, Dept Biotechnol Chem & Environm Engn'], 'affiliations': [{'raw_affiliation_string': 'Univ Aalborg, Aalborg University, Dept Biotechnol Chem & Environm Engn', 'institution_ids': ['https://openalex.org/I891191580']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069311737', 'display_name': 'Jan Martinussen', 'orcid': 'https://orcid.org/0000-0001-6223-9322'}, 'institutions': [{'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'J Martinussen', 'raw_affiliation_strings': ['Tech Univ Denmark, Technical University of Denmark, Dept Syst Biol, Ctr Syst Microbiol'], 'affiliations': [{'raw_affiliation_string': 'Tech Univ Denmark, Technical University of Denmark, Dept Syst Biol, Ctr Syst Microbiol', 'institution_ids': ['https://openalex.org/I96673099']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5028072132', 'display_name': 'Søren J. Sørensen', 'orcid': 'https://orcid.org/0000-0001-6227-9906'}, 'institutions': [{'id': 'https://openalex.org/I124055696', 'display_name': 'University of Copenhagen', 'ror': 'https://ror.org/035b05819', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I124055696']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'SJ Sørensen', 'raw_affiliation_strings': ['Univ Copenhagen, University of Copenhagen, Dept Biol, Mol Microbial Ecol Grp'], 'affiliations': [{'raw_affiliation_string': 'Univ Copenhagen, University of Copenhagen, Dept Biol, Mol Microbial Ecol Grp', 'institution_ids': ['https://openalex.org/I124055696']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074576497', 'display_name': 'Anna Eliasson Lantz', 'orcid': 'https://orcid.org/0000-0003-1547-9299'}, 'institutions': [{'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'AE Lantz', 'raw_affiliation_strings': ['Tech Univ Denmark, Technical University of Denmark, Dept Syst Biol, Ctr Microbial Technol'], 'affiliations': [{'raw_affiliation_string': 'Tech Univ Denmark, Technical University of Denmark, Dept Syst Biol, Ctr Microbial Technol', 'institution_ids': ['https://openalex.org/I96673099']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5021629663', 'display_name': 'Krist V. Gernaey', 'orcid': 'https://orcid.org/0000-0002-0364-1773'}, 'institutions': [{'id': 'https://openalex.org/I96673099', 'display_name': 'Technical University of Denmark', 'ror': 'https://ror.org/04qtj9h94', 'country_code': 'DK', 'type': 'education', 'lineage': ['https://openalex.org/I96673099']}], 'countries': ['DK'], 'is_corresponding': False, 'raw_author_name': 'KV Gernaey', 'raw_affiliation_strings': ['Tech Univ Denmark, Technical University of Denmark, Ctr Proc Engn & Technol, Dept Chem & Biochem Engn'], 'affiliations': [{'raw_affiliation_string': 'Tech Univ Denmark, Technical University of Denmark, Ctr Proc Engn & Technol, Dept Chem & Biochem Engn', 'institution_ids': ['https://openalex.org/I96673099']}]}], 'countries_distinct_count': 4, 'institutions_distinct_count': 6, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 5300, 'currency': 'USD', 'value_usd': 5300, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.451, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 116, 'citation_normalized_percentile': {'value': 0.699569, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '29', 'issue': '6', 'first_page': '575', 'last_page': '599'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11663', 'display_name': 'Recombinant Protein Production in Mammalian and Insect Cells', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11663', 'display_name': 'Recombinant Protein Production in Mammalian and Insect Cells', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11190', 'display_name': '3D Bioprinting Technology', 'score': 0.9941, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10621', 'display_name': 'Stochasticity in Gene Regulatory Networks', 'score': 0.9907, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/single-cell-analysis', 'display_name': 'Single-Cell Analysis', 'score': 0.530611}], 'concepts': [{'id': 'https://openalex.org/C4916135', 'wikidata': 'https://www.wikidata.org/wiki/Q4119055', 'display_name': 'Bioprocess', 'level': 2, 'score': 0.70489526}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.58752346}, {'id': 'https://openalex.org/C183696295', 'wikidata': 'https://www.wikidata.org/wiki/Q2487696', 'display_name': 'Biochemical engineering', 'level': 1, 'score': 0.5854963}, {'id': 'https://openalex.org/C41008148', 'wikidata': 'https://www.wikidata.org/wiki/Q21198', 'display_name': 'Computer science', 'level': 0, 'score': 0.50079346}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.23215234}, {'id': 'https://openalex.org/C127413603', 'wikidata': 'https://www.wikidata.org/wiki/Q11023', 'display_name': 'Engineering', 'level': 0, 'score': 0.15994737}, {'id': 'https://openalex.org/C144024400', 'wikidata': 'https://www.wikidata.org/wiki/Q21201', 'display_name': 'Sociology', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C149923435', 'wikidata': 'https://www.wikidata.org/wiki/Q37732', 'display_name': 'Demography', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C151730666', 'wikidata': 'https://www.wikidata.org/wiki/Q7205', 'display_name': 'Paleontology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D003585', 'descriptor_name': 'Cell Biology', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D002468', 'descriptor_name': 'Cell Physiological Phenomena', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D003584', 'descriptor_name': 'Cytological Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008954', 'descriptor_name': 'Models, Biological', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D049490', 'descriptor_name': 'Systems Biology', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}], 'locations_count': 3, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.biotechadv.2011.03.007', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S160877137', 'display_name': 'Biotechnology Advances', 'issn_l': '0734-9750', 'issn': ['0734-9750', '1873-1899'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://biblio.ugent.be/publication/1965006/file/1965749', 'pdf_url': 'https://biblio.ugent.be/publication/1965006/file/1965749', 'source': {'id': 'https://openalex.org/S4306400478', 'display_name': 'Ghent University Academic Bibliography (Ghent University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I32597200', 'host_organization_name': 'Ghent University', 'host_organization_lineage': ['https://openalex.org/I32597200'], 'host_organization_lineage_names': ['Ghent University'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/21540103', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://biblio.ugent.be/publication/1965006/file/1965749', 'pdf_url': 'https://biblio.ugent.be/publication/1965006/file/1965749', 'source': {'id': 'https://openalex.org/S4306400478', 'display_name': 'Ghent University Academic Bibliography (Ghent University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I32597200', 'host_organization_name': 'Ghent University', 'host_organization_lineage': ['https://openalex.org/I32597200'], 'host_organization_lineage_names': ['Ghent University'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320309756', 'funder_display_name': 'Strategiske Forskningsråd', 'award_id': '09-065160'}], 'datasets': [], 'versions': [], 'referenced_works_count': 312, 'referenced_works': ['https://openalex.org/W1507846562', 'https://openalex.org/W1509558741', 'https://openalex.org/W1519297291', 'https://openalex.org/W1525445008', 'https://openalex.org/W1533811233', 'https://openalex.org/W1541316156', 'https://openalex.org/W1564970155', 'https://openalex.org/W1583685756', 'https://openalex.org/W1591819404', 'https://openalex.org/W1595111220', 'https://openalex.org/W1599804049', 'https://openalex.org/W1728954299', 'https://openalex.org/W1819132522', 'https://openalex.org/W1834229661', 'https://openalex.org/W1869132112', 'https://openalex.org/W1891609328', 'https://openalex.org/W18970597', 'https://openalex.org/W1901622693', 'https://openalex.org/W1919954453', 'https://openalex.org/W1949378404', 'https://openalex.org/W1949454870', 'https://openalex.org/W1960372815', 'https://openalex.org/W1963654627', 'https://openalex.org/W1965169361', 'https://openalex.org/W1965460969', 'https://openalex.org/W1966535350', 'https://openalex.org/W1967738476', 'https://openalex.org/W1967956707', 'https://openalex.org/W1969128187', 'https://openalex.org/W1969376600', 'https://openalex.org/W1970240510', 'https://openalex.org/W1970478787', 'https://openalex.org/W1971227936', 'https://openalex.org/W1974033770', 'https://openalex.org/W1976571122', 'https://openalex.org/W1976836197', 'https://openalex.org/W1977186059', 'https://openalex.org/W1977493314', 'https://openalex.org/W1978064336', 'https://openalex.org/W1978067783', 'https://openalex.org/W1979008608', 'https://openalex.org/W1979221572', 'https://openalex.org/W1980231032', 'https://openalex.org/W1980722358', 'https://openalex.org/W1980740090', 'https://openalex.org/W1980869844', 'https://openalex.org/W1981312471', 'https://openalex.org/W1981396994', 'https://openalex.org/W1982401876', 'https://openalex.org/W1982650807', 'https://openalex.org/W1982732566', 'https://openalex.org/W1983933779', 'https://openalex.org/W1984321826', 'https://openalex.org/W1985106164', 'https://openalex.org/W1985492146', 'https://openalex.org/W1985787317', 'https://openalex.org/W1986727671', 'https://openalex.org/W1988195870', 'https://openalex.org/W1990979925', 'https://openalex.org/W1991508286', 'https://openalex.org/W1991760727', 'https://openalex.org/W1992641506', 'https://openalex.org/W1993163345', 'https://openalex.org/W1993670200', 'https://openalex.org/W1996064131', 'https://openalex.org/W1996460711', 'https://openalex.org/W1996811540', 'https://openalex.org/W1997119027', 'https://openalex.org/W1998047501', 'https://openalex.org/W1998845308', 'https://openalex.org/W1999024846', 'https://openalex.org/W2000183246', 'https://openalex.org/W2001037075', 'https://openalex.org/W2001343626', 'https://openalex.org/W2002115571', 'https://openalex.org/W2003895273', 'https://openalex.org/W2005227978', 'https://openalex.org/W2005360152', 'https://openalex.org/W2006685379', 'https://openalex.org/W2007558289', 'https://openalex.org/W2009093015', 'https://openalex.org/W2010680821', 'https://openalex.org/W2010729987', 'https://openalex.org/W2012715459', 'https://openalex.org/W2013008985', 'https://openalex.org/W2013115758', 'https://openalex.org/W2013573429', 'https://openalex.org/W2014106495', 'https://openalex.org/W2015616694', 'https://openalex.org/W2016140326', 'https://openalex.org/W2016166286', 'https://openalex.org/W2017287753', 'https://openalex.org/W2017493259', 'https://openalex.org/W2018397292', 'https://openalex.org/W2019462270', 'https://openalex.org/W2019552004', 'https://openalex.org/W2020340205', 'https://openalex.org/W2020668111', 'https://openalex.org/W2020669137', 'https://openalex.org/W2021188701', 'https://openalex.org/W2021192048', 'https://openalex.org/W2021486592', 'https://openalex.org/W2021789309', 'https://openalex.org/W2024543003', 'https://openalex.org/W2025762665', 'https://openalex.org/W2027746982', 'https://openalex.org/W2027761702', 'https://openalex.org/W2029089533', 'https://openalex.org/W2029536234', 'https://openalex.org/W2030401917', 'https://openalex.org/W2031382376', 'https://openalex.org/W2031944646', 'https://openalex.org/W2032282036', 'https://openalex.org/W2032579724', 'https://openalex.org/W2033910658', 'https://openalex.org/W2034231475', 'https://openalex.org/W2034659113', 'https://openalex.org/W2035230904', 'https://openalex.org/W2036010268', 'https://openalex.org/W2036088435', 'https://openalex.org/W2036561093', 'https://openalex.org/W2036742051', 'https://openalex.org/W2036785581', 'https://openalex.org/W2037672355', 'https://openalex.org/W2037928350', 'https://openalex.org/W2038444558', 'https://openalex.org/W2038756774', 'https://openalex.org/W2039713268', 'https://openalex.org/W2039849348', 'https://openalex.org/W2040968102', 'https://openalex.org/W2041687536', 'https://openalex.org/W2042062162', 'https://openalex.org/W2042829929', 'https://openalex.org/W2044058396', 'https://openalex.org/W2046975114', 'https://openalex.org/W2047960542', 'https://openalex.org/W2049848001', 'https://openalex.org/W2050461122', 'https://openalex.org/W2051698985', 'https://openalex.org/W2052982059', 'https://openalex.org/W2053803155', 'https://openalex.org/W2053921060', 'https://openalex.org/W2055666272', 'https://openalex.org/W2056469199', 'https://openalex.org/W2058221907', 'https://openalex.org/W2058346916', 'https://openalex.org/W2060232163', 'https://openalex.org/W2060520177', 'https://openalex.org/W2060836400', 'https://openalex.org/W2061121255', 'https://openalex.org/W2062115723', 'https://openalex.org/W2062141889', 'https://openalex.org/W2062402428', 'https://openalex.org/W2062898787', 'https://openalex.org/W2063372321', 'https://openalex.org/W2064927748', 'https://openalex.org/W2066956149', 'https://openalex.org/W2067211564', 'https://openalex.org/W2067780907', 'https://openalex.org/W2069676009', 'https://openalex.org/W2069726408', 'https://openalex.org/W2070052311', 'https://openalex.org/W2070072160', 'https://openalex.org/W2072080572', 'https://openalex.org/W2072428000', 'https://openalex.org/W2072897152', 'https://openalex.org/W2073158988', 'https://openalex.org/W2073342698', 'https://openalex.org/W2073796239', 'https://openalex.org/W2074040830', 'https://openalex.org/W2074930902', 'https://openalex.org/W2075526709', 'https://openalex.org/W2076095656', 'https://openalex.org/W2076742004', 'https://openalex.org/W2077308010', 'https://openalex.org/W2077341939', 'https://openalex.org/W2077835601', 'https://openalex.org/W2077930487', 'https://openalex.org/W2079194698', 'https://openalex.org/W2080228586', 'https://openalex.org/W2080760786', 'https://openalex.org/W2080823019', 'https://openalex.org/W2085850813', 'https://openalex.org/W2085967779', 'https://openalex.org/W2087140501', 'https://openalex.org/W2087326346', 'https://openalex.org/W2087823077', 'https://openalex.org/W2088077234', 'https://openalex.org/W2088594360', 'https://openalex.org/W2089039326', 'https://openalex.org/W2089367766', 'https://openalex.org/W2089526905', 'https://openalex.org/W2090249020', 'https://openalex.org/W2090437967', 'https://openalex.org/W2093771356', 'https://openalex.org/W2094051182', 'https://openalex.org/W2094971934', 'https://openalex.org/W2095744018', 'https://openalex.org/W2096211374', 'https://openalex.org/W2097219388', 'https://openalex.org/W2097446839', 'https://openalex.org/W2098066769', 'https://openalex.org/W2101225670', 'https://openalex.org/W2101591208', 'https://openalex.org/W2103858717', 'https://openalex.org/W2104810358', 'https://openalex.org/W2106097745', 'https://openalex.org/W2106938045', 'https://openalex.org/W2107109081', 'https://openalex.org/W2107828561', 'https://openalex.org/W2109717868', 'https://openalex.org/W2109947095', 'https://openalex.org/W2109995050', 'https://openalex.org/W2110128638', 'https://openalex.org/W2110141867', 'https://openalex.org/W2110310164', 'https://openalex.org/W2110480682', 'https://openalex.org/W2111452172', 'https://openalex.org/W2113067152', 'https://openalex.org/W2113487205', 'https://openalex.org/W2113904156', 'https://openalex.org/W2114783837', 'https://openalex.org/W2115068023', 'https://openalex.org/W2115177365', 'https://openalex.org/W2115230397', 'https://openalex.org/W2115370342', 'https://openalex.org/W2115937014', 'https://openalex.org/W2116205101', 'https://openalex.org/W2116778518', 'https://openalex.org/W2120779934', 'https://openalex.org/W2121901998', 'https://openalex.org/W2123605247', 'https://openalex.org/W2124875555', 'https://openalex.org/W2125831873', 'https://openalex.org/W2125882779', 'https://openalex.org/W2125902873', 'https://openalex.org/W2126067942', 'https://openalex.org/W2126461778', 'https://openalex.org/W2127068865', 'https://openalex.org/W2127224317', 'https://openalex.org/W2127429228', 'https://openalex.org/W2127786548', 'https://openalex.org/W2127951081', 'https://openalex.org/W2128113495', 'https://openalex.org/W2130316189', 'https://openalex.org/W2130783858', 'https://openalex.org/W2132245233', 'https://openalex.org/W2132990040', 'https://openalex.org/W2133480990', 'https://openalex.org/W2134061032', 'https://openalex.org/W2134667534', 'https://openalex.org/W2135440692', 'https://openalex.org/W2135527399', 'https://openalex.org/W2135756479', 'https://openalex.org/W2136109455', 'https://openalex.org/W2137799314', 'https://openalex.org/W2141361677', 'https://openalex.org/W2144229671', 'https://openalex.org/W2145274698', 'https://openalex.org/W2145467174', 'https://openalex.org/W2146048235', 'https://openalex.org/W2146405468', 'https://openalex.org/W2147472054', 'https://openalex.org/W2148323109', 'https://openalex.org/W2149792264', 'https://openalex.org/W2151112561', 'https://openalex.org/W2151351133', 'https://openalex.org/W2154321074', 'https://openalex.org/W2155231903', 'https://openalex.org/W2155664691', 'https://openalex.org/W2157408451', 'https://openalex.org/W2158650507', 'https://openalex.org/W2160654834', 'https://openalex.org/W2161041942', 'https://openalex.org/W2162246107', 'https://openalex.org/W2162823101', 'https://openalex.org/W2163191416', 'https://openalex.org/W2163707182', 'https://openalex.org/W2163904534', 'https://openalex.org/W2165829105', 'https://openalex.org/W2167747827', 'https://openalex.org/W2169632824', 'https://openalex.org/W2170515238', 'https://openalex.org/W2171102932', 'https://openalex.org/W2171463471', 'https://openalex.org/W2171529481', 'https://openalex.org/W2171692293', 'https://openalex.org/W2171996869', 'https://openalex.org/W2205653758', 'https://openalex.org/W2257481305', 'https://openalex.org/W2337996045', 'https://openalex.org/W2415433863', 'https://openalex.org/W245532858', 'https://openalex.org/W2498454769', 'https://openalex.org/W2499620034', 'https://openalex.org/W2804516452', 'https://openalex.org/W4229846132', 'https://openalex.org/W4230350617', 'https://openalex.org/W4233808990', 'https://openalex.org/W4238101851', 'https://openalex.org/W4241177869', 'https://openalex.org/W4244197022', 'https://openalex.org/W4245239376', 'https://openalex.org/W4247623139', 'https://openalex.org/W4248463836', 'https://openalex.org/W4253882572', 'https://openalex.org/W4294232809', 'https://openalex.org/W579830666', 'https://openalex.org/W610761774', 'https://openalex.org/W613253038', 'https://openalex.org/W66751771', 'https://openalex.org/W993219267'], 'related_works': ['https://openalex.org/W4300826710', 'https://openalex.org/W3180666438', 'https://openalex.org/W3033918039', 'https://openalex.org/W2981179043', 'https://openalex.org/W2573602707', 'https://openalex.org/W2330704722', 'https://openalex.org/W2083924127', 'https://openalex.org/W2057263938', 'https://openalex.org/W2005275448', 'https://openalex.org/W1568297223'], 'abstract_inverted_index': {'With': [0, 117], 'the': [1, 5, 18, 25, 35, 50, 57, 74, 99, 124, 151, 181], 'continuous': [2], 'development,': [3], 'in': [4, 98], 'last': [6], 'decades,': [7], 'of': [8, 20, 27, 52, 64, 76, 81, 101, 110, 126, 167, 183, 186], 'analytical': [9, 32], 'techniques': [10], 'providing': [11], 'complex': [12, 36], 'information': [13], 'at': [14], 'single': [15], 'cell': [16, 21, 77, 132, 145, 168], 'level,': [17], 'study': [19], 'heterogeneity': [22, 78, 96, 134], 'has': [23, 113], 'been': [24], 'focus': [26], 'several': [28], 'research': [29], 'projects': [30], 'within': [31], 'biotechnology.': [33], 'Nonetheless,': [34], 'interplay': [37], 'between': [38, 155], 'environmental': [39], 'changes': [40], 'and': [41, 49, 62, 157], 'cellular': [42], 'responses': [43], 'is': [44, 66, 85, 171], 'yet': [45], 'not': [46], 'fully': [47], 'understood,': [48], 'integration': [51], 'this': [53, 118], 'new': [54], 'knowledge': [55], 'into': [56], 'strategies': [58], 'for': [59, 130, 141], 'design,': [60], 'operation': [61], 'control': [63, 104, 185], 'bioprocesses': [65], 'far': [67], 'from': [68], 'being': [69], 'an': [70], 'established': [71], 'reality.': [72], 'Indeed,': [73], 'impact': [75], 'on': [79], 'productivity': [80], 'large': [82], 'scale': [83], 'cultivations': [84], 'acknowledged': [86], 'but': [87], 'seldom': [88], 'accounted': [89], 'for.': [90], 'In': [91], 'order': [92], 'to': [93, 114, 122, 161, 178, 180], 'include': [94], 'population': [95, 133], 'mechanisms': [97], 'development': [100, 182], 'novel': [102], 'bioprocess': [103], 'strategies,': [105], 'a': [106, 163, 172], 'reliable': [107, 164], 'mathematical': [108], 'description': [109, 166], 'such': [111, 175], 'phenomena': [112], 'be': [115], 'developed.': [116], 'review,': [119], 'we': [120], 'search': [121], 'summarize': [123], 'potential': [125], 'currently': [127], 'available': [128], 'methods': [129], 'monitoring': [131], 'as': [135, 137], 'well': [136], 'model': [138], 'frameworks': [139], 'suitable': [140], 'describing': [142], 'dynamic': [143], 'heterogeneous': [144], 'populations.': [146], 'We': [147], 'will': [148], 'furthermore': [149], 'underline': [150], 'highly': [152], 'important': [153], 'coordination': [154], 'experimental': [156], 'modeling': [158], 'efforts': [159], 'necessary': [160], 'attain': [162], 'quantitative': [165], 'heterogeneity,': [169], 'which': [170], 'necessity': [173], 'if': [174], 'models': [176], 'are': [177], 'contribute': [179], 'improved': [184], 'bioprocesses.': [187]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2137018402', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 7}, {'year': 2022, 'cited_by_count': 11}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 6}, {'year': 2019, 'cited_by_count': 6}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 15}, {'year': 2016, 'cited_by_count': 5}, {'year': 2015, 'cited_by_count': 9}, {'year': 2014, 'cited_by_count': 14}, {'year': 2013, 'cited_by_count': 13}, {'year': 2012, 'cited_by_count': 12}], 'updated_date': '2024-09-13T19:07:20.935910', 'created_date': '2016-06-24'}