Publication Information

{'id': 'https://openalex.org/W2136942244', 'doi': 'https://doi.org/10.1146/annurev.biochem.76.050106.093909', 'title': 'The Nonsense-Mediated Decay RNA Surveillance Pathway', 'display_name': 'The Nonsense-Mediated Decay RNA Surveillance Pathway', 'publication_year': 2007, 'publication_date': '2007-02-09', 'ids': {'openalex': 'https://openalex.org/W2136942244', 'doi': 'https://doi.org/10.1146/annurev.biochem.76.050106.093909', 'mag': '2136942244', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/17352659'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1146/annurev.biochem.76.050106.093909', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S53860259', 'display_name': 'Annual Review of Biochemistry', 'issn_l': '0066-4154', 'issn': ['0066-4154', '1545-4509'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320373', 'host_organization_name': 'Annual Reviews', 'host_organization_lineage': ['https://openalex.org/P4310320373'], 'host_organization_lineage_names': ['Annual Reviews'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5007608851', 'display_name': 'Yao-Fu Chang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yao-Fu Chang', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060974352', 'display_name': 'J. Saadi Imam', 'orcid': 'https://orcid.org/0000-0003-3463-838X'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'J. Saadi Imam', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030;, ,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030;, ,', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5028641640', 'display_name': 'Miles Wilkinson', 'orcid': 'https://orcid.org/0000-0002-6416-3058'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Miles F. Wilkinson', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030;, ,'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030;, ,', 'institution_ids': ['https://openalex.org/I1343551460']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 9.656, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 1219, 'citation_normalized_percentile': {'value': 0.999684, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '76', 'issue': '1', 'first_page': '51', 'last_page': '74'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10604', 'display_name': 'RNA Research and Splicing', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11482', 'display_name': 'RNA modifications and cancer', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10521', 'display_name': 'RNA and protein synthesis mechanisms', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/nonsense-mediated-decay', 'display_name': 'Nonsense-Mediated Decay', 'score': 0.5506734}, {'id': 'https://openalex.org/keywords/nonsense', 'display_name': 'Nonsense', 'score': 0.5374814}], 'concepts': [{'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.5557517}, {'id': 'https://openalex.org/C70219777', 'wikidata': 'https://www.wikidata.org/wiki/Q14911527', 'display_name': 'Nonsense-mediated decay', 'level': 5, 'score': 0.5506734}, {'id': 'https://openalex.org/C62923972', 'wikidata': 'https://www.wikidata.org/wiki/Q600499', 'display_name': 'Nonsense', 'level': 3, 'score': 0.5374814}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.40929437}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.39902812}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.37697697}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.3436895}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.33038428}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.19923738}, {'id': 'https://openalex.org/C54458228', 'wikidata': 'https://www.wikidata.org/wiki/Q237218', 'display_name': 'RNA splicing', 'level': 4, 'score': 0.06842247}], 'mesh': [{'descriptor_ui': 'D020125', 'descriptor_name': 'Mutation, Missense', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D020871', 'descriptor_name': 'RNA Stability', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003062', 'descriptor_name': 'Codon', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005091', 'descriptor_name': 'Exons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D046912', 'descriptor_name': 'Multiprotein Complexes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014176', 'descriptor_name': 'Protein Biosynthesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020365', 'descriptor_name': 'RNA Helicases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012326', 'descriptor_name': 'RNA Splicing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D016601', 'descriptor_name': 'RNA-Binding Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016601', 'descriptor_name': 'RNA-Binding Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015534', 'descriptor_name': 'Trans-Activators', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D014157', 'descriptor_name': 'Transcription Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1146/annurev.biochem.76.050106.093909', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S53860259', 'display_name': 'Annual Review of Biochemistry', 'issn_l': '0066-4154', 'issn': ['0066-4154', '1545-4509'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320373', 'host_organization_name': 'Annual Reviews', 'host_organization_lineage': ['https://openalex.org/P4310320373'], 'host_organization_lineage_names': ['Annual Reviews'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/17352659', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 169, 'referenced_works': ['https://openalex.org/W1268830682', 'https://openalex.org/W1508541438', 'https://openalex.org/W1880070854', 'https://openalex.org/W1894352320', 'https://openalex.org/W1921593493', 'https://openalex.org/W1954463457', 'https://openalex.org/W1970658892', 'https://openalex.org/W1971011130', 'https://openalex.org/W1974199167', 'https://openalex.org/W1974431355', 'https://openalex.org/W1975117841', 'https://openalex.org/W1975669874', 'https://openalex.org/W1976407358', 'https://openalex.org/W1979021029', 'https://openalex.org/W1980644980', 'https://openalex.org/W1980728452', 'https://openalex.org/W1983060008', 'https://openalex.org/W1983136047', 'https://openalex.org/W1984356380', 'https://openalex.org/W1985046929', 'https://openalex.org/W1985645826', 'https://openalex.org/W1985847018', 'https://openalex.org/W1985991078', 'https://openalex.org/W1988611580', 'https://openalex.org/W1988750240', 'https://openalex.org/W1995737813', 'https://openalex.org/W1996249161', 'https://openalex.org/W1996279504', 'https://openalex.org/W1997521460', 'https://openalex.org/W1997980793', 'https://openalex.org/W2003609112', 'https://openalex.org/W2003987858', 'https://openalex.org/W2004030503', 'https://openalex.org/W2005369831', 'https://openalex.org/W2006094217', 'https://openalex.org/W2009193602', 'https://openalex.org/W2009757848', 'https://openalex.org/W2010967496', 'https://openalex.org/W2011239877', 'https://openalex.org/W2011405092', 'https://openalex.org/W2012106075', 'https://openalex.org/W2012288774', 'https://openalex.org/W2014028277', 'https://openalex.org/W2014349878', 'https://openalex.org/W2015775176', 'https://openalex.org/W2017429261', 'https://openalex.org/W2018914487', 'https://openalex.org/W2019860831', 'https://openalex.org/W2021006884', 'https://openalex.org/W2021518210', 'https://openalex.org/W2021580115', 'https://openalex.org/W2024039709', 'https://openalex.org/W2027653128', 'https://openalex.org/W2029903479', 'https://openalex.org/W2030365575', 'https://openalex.org/W2030626178', 'https://openalex.org/W2030910590', 'https://openalex.org/W2031540808', 'https://openalex.org/W2032747482', 'https://openalex.org/W2034339628', 'https://openalex.org/W2034542637', 'https://openalex.org/W2034575258', 'https://openalex.org/W2035995486', 'https://openalex.org/W2036625038', 'https://openalex.org/W2037139999', 'https://openalex.org/W2037576800', 'https://openalex.org/W2040174498', 'https://openalex.org/W2040391070', 'https://openalex.org/W2041270909', 'https://openalex.org/W2041299751', 'https://openalex.org/W2042868918', 'https://openalex.org/W2043493794', 'https://openalex.org/W2047017978', 'https://openalex.org/W2048775343', 'https://openalex.org/W2049369269', 'https://openalex.org/W2051393205', 'https://openalex.org/W2056329906', 'https://openalex.org/W2057241729', 'https://openalex.org/W2058755719', 'https://openalex.org/W2058809417', 'https://openalex.org/W2059790044', 'https://openalex.org/W2060077330', 'https://openalex.org/W2069501735', 'https://openalex.org/W2071415265', 'https://openalex.org/W2074937111', 'https://openalex.org/W2075613251', 'https://openalex.org/W2077686875', 'https://openalex.org/W2079810511', 'https://openalex.org/W2080409413', 'https://openalex.org/W2080755926', 'https://openalex.org/W2081646062', 'https://openalex.org/W2084084328', 'https://openalex.org/W2084212780', 'https://openalex.org/W2084715034', 'https://openalex.org/W2085153279', 'https://openalex.org/W2085192863', 'https://openalex.org/W2087040025', 'https://openalex.org/W2087177055', 'https://openalex.org/W2087653624', 'https://openalex.org/W2087672655', 'https://openalex.org/W2087793363', 'https://openalex.org/W2088566278', 'https://openalex.org/W2094883326', 'https://openalex.org/W2098011283', 'https://openalex.org/W2100763482', 'https://openalex.org/W2101617498', 'https://openalex.org/W2102018304', 'https://openalex.org/W2102161874', 'https://openalex.org/W2102622721', 'https://openalex.org/W2104521909', 'https://openalex.org/W2105402655', 'https://openalex.org/W2106227248', 'https://openalex.org/W2106755835', 'https://openalex.org/W2107366069', 'https://openalex.org/W2107594198', 'https://openalex.org/W2107807571', 'https://openalex.org/W2109010031', 'https://openalex.org/W2109276727', 'https://openalex.org/W2109846882', 'https://openalex.org/W2112001822', 'https://openalex.org/W2113741521', 'https://openalex.org/W2114152083', 'https://openalex.org/W2114891593', 'https://openalex.org/W2114991027', 'https://openalex.org/W2115700741', 'https://openalex.org/W2117770954', 'https://openalex.org/W2119214514', 'https://openalex.org/W2120564986', 'https://openalex.org/W2127408843', 'https://openalex.org/W2127534226', 'https://openalex.org/W2127860156', 'https://openalex.org/W2129663574', 'https://openalex.org/W2132264109', 'https://openalex.org/W2132300055', 'https://openalex.org/W2133031407', 'https://openalex.org/W2133043413', 'https://openalex.org/W2133902192', 'https://openalex.org/W2134530067', 'https://openalex.org/W2135349135', 'https://openalex.org/W2136897565', 'https://openalex.org/W2137302306', 'https://openalex.org/W2137990405', 'https://openalex.org/W2138347882', 'https://openalex.org/W2139015089', 'https://openalex.org/W2139905086', 'https://openalex.org/W2139953626', 'https://openalex.org/W2142812553', 'https://openalex.org/W2145322004', 'https://openalex.org/W2148561255', 'https://openalex.org/W2150245940', 'https://openalex.org/W2154063562', 'https://openalex.org/W2156086097', 'https://openalex.org/W2158143427', 'https://openalex.org/W2158986665', 'https://openalex.org/W2160760837', 'https://openalex.org/W2161269665', 'https://openalex.org/W2162195906', 'https://openalex.org/W2162338462', 'https://openalex.org/W2162572389', 'https://openalex.org/W2164554859', 'https://openalex.org/W2164735945', 'https://openalex.org/W2165945808', 'https://openalex.org/W2166206156', 'https://openalex.org/W2169525767', 'https://openalex.org/W2170365162', 'https://openalex.org/W2170418856', 'https://openalex.org/W2312821521', 'https://openalex.org/W4232936625', 'https://openalex.org/W4242521331'], 'related_works': ['https://openalex.org/W4391375266', 'https://openalex.org/W4391081182', 'https://openalex.org/W4206156206', 'https://openalex.org/W3181314097', 'https://openalex.org/W2939923831', 'https://openalex.org/W2564018796', 'https://openalex.org/W2158191710', 'https://openalex.org/W2050199116', 'https://openalex.org/W1570809968', 'https://openalex.org/W1493907149'], 'abstract_inverted_index': {'Nonsense-mediated': [0], 'mRNA': [1, 101], 'decay': [2], '(NMD)': [3], 'is': [4, 63], 'a': [5, 58, 72, 93, 112], 'quality-control': [6], 'mechanism': [7, 38], 'that': [8, 62, 97], 'selectively': [9], 'degrades': [10], 'mRNAs': [11, 20, 67], 'harboring': [12], 'premature': [13], 'termination': [14], '(nonsense)': [15], 'codons.': [16], 'If': [17], 'translated,': [18], 'these': [19, 106], 'can': [21, 128], 'produce': [22], 'truncated': [23], 'proteins': [24], 'with': [25], 'dominant-negative': [26], 'or': [27, 133], 'deleterious': [28], 'gain-of-function': [29], 'activities.': [30], 'In': [31], 'this': [32, 79], 'review,': [33], 'we': [34], 'describe': [35, 57], 'the': [36, 88, 137], 'molecular': [37], 'of': [39, 95, 115, 136], 'NMD.': [40], 'We': [41, 55, 103], 'first': [42], 'cover': [43], 'conserved': [44], 'factors': [45, 85, 132], 'known': [46], 'to': [47, 100], 'be': [48], 'involved': [49], 'in': [50, 52, 117], 'NMD': [51, 84], 'all': [53], 'eukaryotes.': [54], 'then': [56], 'unique': [59], 'protein': [60], 'complex': [61, 81], 'deposited': [64], 'on': [65], 'mammalian': [66], 'during': [68, 111], 'splicing,': [69], 'which': [70], 'defines': [71], 'stop': [73, 90], 'codon': [74, 91], 'as': [75], 'premature.': [76], 'Interaction': [77], 'between': [78], 'exon-junction': [80], '(EJC)': [82], 'and': [83, 119, 125], 'assembled': [86], 'at': [87], 'upstream': [89], 'triggers': [92], 'series': [94], 'steps': [96], 'ultimately': [98], 'lead': [99], 'decay.': [102], 'discuss': [104], 'whether': [105, 126], 'proofreading': [107], 'events': [108], 'preferentially': [109], 'occur': [110], '“pioneer”': [113], 'round': [114], 'translation': [116], 'higher': [118], 'lower': [120], 'eukaryotes,': [121], 'their': [122], 'cellular': [123], 'location,': [124], 'they': [127], 'use': [129], 'alternative': [130], 'EJC': [131], 'act': [134], 'independent': [135], 'EJC.': [138]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2136942244', 'counts_by_year': [{'year': 2024, 'cited_by_count': 37}, {'year': 2023, 'cited_by_count': 43}, {'year': 2022, 'cited_by_count': 55}, {'year': 2021, 'cited_by_count': 48}, {'year': 2020, 'cited_by_count': 61}, {'year': 2019, 'cited_by_count': 64}, {'year': 2018, 'cited_by_count': 48}, {'year': 2017, 'cited_by_count': 67}, {'year': 2016, 'cited_by_count': 67}, {'year': 2015, 'cited_by_count': 66}, {'year': 2014, 'cited_by_count': 76}, {'year': 2013, 'cited_by_count': 110}, {'year': 2012, 'cited_by_count': 117}], 'updated_date': '2024-12-18T22:11:49.965004', 'created_date': '2016-06-24'}