Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2136149088', 'doi': 'https://doi.org/10.1002/art.30613', 'title': 'A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus', 'display_name': 'A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus', 'publication_year': 2011, 'publication_date': '2011-11-29', 'ids': {'openalex': 'https://openalex.org/W2136149088', 'doi': 'https://doi.org/10.1002/art.30613', 'mag': '2136149088', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/22127708', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/5007058'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/art.30613', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S132787887', 'display_name': 'Arthritis & Rheumatism', 'issn_l': '0004-3591', 'issn': ['0004-3591', '1529-0131'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc5007058?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5076651506', 'display_name': 'Richard Furie', 'orcid': 'https://orcid.org/0000-0001-6712-1585'}, 'institutions': [{'id': 'https://openalex.org/I1302444339', 'display_name': 'Northwell Health', 'ror': 'https://ror.org/02bxt4m23', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1302444339']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Richard Furie', 'raw_affiliation_strings': ['North Shore Long Island Jewish Health System, Lake Success, New York.'], 'affiliations': [{'raw_affiliation_string': 'North Shore Long Island Jewish Health System, Lake Success, New York.', 'institution_ids': ['https://openalex.org/I1302444339']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082713013', 'display_name': 'Michelle Petri', 'orcid': 'https://orcid.org/0000-0003-1441-5373'}, 'institutions': [{'id': 'https://openalex.org/I2799853436', 'display_name': 'Johns Hopkins Medicine', 'ror': 'https://ror.org/037zgn354', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799853436']}, {'id': 'https://openalex.org/I145311948', 'display_name': 'Johns Hopkins University', 'ror': 'https://ror.org/00za53h95', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I145311948']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michelle Petri', 'raw_affiliation_strings': ['Johns Hopkins University, School of Medicine, Baltimore, Maryland'], 'affiliations': [{'raw_affiliation_string': 'Johns Hopkins University, School of Medicine, Baltimore, Maryland', 'institution_ids': ['https://openalex.org/I2799853436', 'https://openalex.org/I145311948']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007653414', 'display_name': 'Omid Zamani', 'orcid': None}, 'institutions': [], 'countries': ['AT'], 'is_corresponding': False, 'raw_author_name': 'Omid Zamani', 'raw_affiliation_strings': ['Rheumazentrum Favoriten, Vienna, Austria'], 'affiliations': [{'raw_affiliation_string': 'Rheumazentrum Favoriten, Vienna, Austria', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5039223320', 'display_name': 'Ricard Cervera', 'orcid': 'https://orcid.org/0000-0001-6085-492X'}, 'institutions': [{'id': 'https://openalex.org/I4210115097', 'display_name': 'Hospital Clínic de Barcelona', 'ror': 'https://ror.org/02a2kzf50', 'country_code': 'ES', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115097']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Ricard Cervera', 'raw_affiliation_strings': ['Hospital Clínic, Barcelona, Spain'], 'affiliations': [{'raw_affiliation_string': 'Hospital Clínic, Barcelona, Spain', 'institution_ids': ['https://openalex.org/I4210115097']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071430304', 'display_name': 'Daniel J. Wallace', 'orcid': 'https://orcid.org/0000-0002-2502-1372'}, 'institutions': [{'id': 'https://openalex.org/I161318765', 'display_name': 'University of California, Los Angeles', 'ror': 'https://ror.org/046rm7j60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I161318765']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daniel J. Wallace', 'raw_affiliation_strings': ['Cedars-Sinai Medical Center/David Geffen School of Medicine at University of California, Los Angeles'], 'affiliations': [{'raw_affiliation_string': 'Cedars-Sinai Medical Center/David Geffen School of Medicine at University of California, Los Angeles', 'institution_ids': ['https://openalex.org/I161318765']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056553996', 'display_name': 'Dana Tegzová', 'orcid': 'https://orcid.org/0000-0002-8735-5001'}, 'institutions': [{'id': 'https://openalex.org/I21250087', 'display_name': 'Charles University', 'ror': 'https://ror.org/024d6js02', 'country_code': 'CZ', 'type': 'education', 'lineage': ['https://openalex.org/I21250087']}], 'countries': ['CZ'], 'is_corresponding': False, 'raw_author_name': 'Dana Tegzová', 'raw_affiliation_strings': ['Charles University, Prague (Czech Republic)'], 'affiliations': [{'raw_affiliation_string': 'Charles University, Prague (Czech Republic)', 'institution_ids': ['https://openalex.org/I21250087']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056786735', 'display_name': 'Jorge Sánchez‐Guerrero', 'orcid': 'https://orcid.org/0000-0003-2548-7276'}, 'institutions': [{'id': 'https://openalex.org/I4210097900', 'display_name': 'Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán', 'ror': 'https://ror.org/00xgvev73', 'country_code': 'MX', 'type': 'facility', 'lineage': ['https://openalex.org/I4210095685', 'https://openalex.org/I4210097900', 'https://openalex.org/I4210128723']}], 'countries': ['MX'], 'is_corresponding': False, 'raw_author_name': 'Jorge Sanchez-Guerrero', 'raw_affiliation_strings': ['Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubrián, Delegacion Tlalpan, Mexico'], 'affiliations': [{'raw_affiliation_string': 'Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubrián, Delegacion Tlalpan, Mexico', 'institution_ids': ['https://openalex.org/I4210097900']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050678710', 'display_name': 'Andreas Schwarting', 'orcid': 'https://orcid.org/0000-0002-0566-598X'}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Andreas Schwarting', 'raw_affiliation_strings': ['Universitatsklinik Mainz, Mainz, Germany, and Sana‐Rheumazentrum Rheinland‐Pfalz AG, Bad Kreuznach, Germany'], 'affiliations': [{'raw_affiliation_string': 'Universitatsklinik Mainz, Mainz, Germany, and Sana‐Rheumazentrum Rheinland‐Pfalz AG, Bad Kreuznach, Germany', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052053321', 'display_name': 'Joan T. Merrill', 'orcid': 'https://orcid.org/0000-0002-4514-2382'}, 'institutions': [{'id': 'https://openalex.org/I30558944', 'display_name': 'Oklahoma Medical Research Foundation', 'ror': 'https://ror.org/035z6xf33', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I30558944']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Joan T. Merrill', 'raw_affiliation_strings': ['Oklahoma‐Medical Research Foundation Oklahoma City'], 'affiliations': [{'raw_affiliation_string': 'Oklahoma‐Medical Research Foundation Oklahoma City', 'institution_ids': ['https://openalex.org/I30558944']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049152508', 'display_name': 'W. Winn Chatham', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I32389192', 'display_name': 'University of Alabama at Birmingham', 'ror': 'https://ror.org/008s83205', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I32389192']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'W. Winn Chatham', 'raw_affiliation_strings': ['University of Alabama at, Birmingham'], 'affiliations': [{'raw_affiliation_string': 'University of Alabama at, Birmingham', 'institution_ids': ['https://openalex.org/I32389192']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019245481', 'display_name': 'William Stohl', 'orcid': 'https://orcid.org/0000-0002-8272-7873'}, 'institutions': [{'id': 'https://openalex.org/I1174212', 'display_name': 'University of Southern California', 'ror': 'https://ror.org/03taz7m60', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I1174212']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'William Stohl', 'raw_affiliation_strings': ['Los Angeles County and University of Southern California Medical Center and University of Southern California Keck School of Medicine, Los Angeles'], 'affiliations': [{'raw_affiliation_string': 'Los Angeles County and University of Southern California Medical Center and University of Southern California Keck School of Medicine, Los Angeles', 'institution_ids': ['https://openalex.org/I1174212']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069100301', 'display_name': 'Ellen M. Ginzler', 'orcid': 'https://orcid.org/0000-0002-7306-7375'}, 'institutions': [{'id': 'https://openalex.org/I181697535', 'display_name': 'SUNY Downstate Medical Center', 'ror': 'https://ror.org/0041qmd21', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I181697535']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ellen M. Ginzler', 'raw_affiliation_strings': ['State University of New York Downstate Medical Center Brooklyn'], 'affiliations': [{'raw_affiliation_string': 'State University of New York Downstate Medical Center Brooklyn', 'institution_ids': ['https://openalex.org/I181697535']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003361274', 'display_name': 'Douglas R. Hough', 'orcid': 'https://orcid.org/0000-0001-7728-816X'}, 'institutions': [{'id': 'https://openalex.org/I108865366', 'display_name': 'Human Genome Sciences (United States)', 'ror': 'https://ror.org/05k1yyh03', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I108865366']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Douglas R. Hough', 'raw_affiliation_strings': ['Human Genome Sciences, Rockville, Maryland'], 'affiliations': [{'raw_affiliation_string': 'Human Genome Sciences, Rockville, Maryland', 'institution_ids': ['https://openalex.org/I108865366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033517368', 'display_name': 'Z. John Zhong', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I108865366', 'display_name': 'Human Genome Sciences (United States)', 'ror': 'https://ror.org/05k1yyh03', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I108865366']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Z. John Zhong', 'raw_affiliation_strings': ['Human Genome Sciences, Rockville, Maryland'], 'affiliations': [{'raw_affiliation_string': 'Human Genome Sciences, Rockville, Maryland', 'institution_ids': ['https://openalex.org/I108865366']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050486969', 'display_name': 'William W. Freimuth', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I108865366', 'display_name': 'Human Genome Sciences (United States)', 'ror': 'https://ror.org/05k1yyh03', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I108865366']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'William Freimuth', 'raw_affiliation_strings': ['Human Genome Sciences, Rockville, Maryland'], 'affiliations': [{'raw_affiliation_string': 'Human Genome Sciences, Rockville, Maryland', 'institution_ids': ['https://openalex.org/I108865366']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5012009272', 'display_name': 'Ronald van Vollenhoven', 'orcid': 'https://orcid.org/0000-0001-6438-8663'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'education', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': False, 'raw_author_name': 'Ronald F. van Vollenhoven', 'raw_affiliation_strings': ['Karolinska Institute, Stockholm, Sweden'], 'affiliations': [{'raw_affiliation_string': 'Karolinska Institute, Stockholm, Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}], 'countries_distinct_count': 7, 'institutions_distinct_count': 13, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 68.842, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 1405, 'citation_normalized_percentile': {'value': 0.944863, 'is_in_top_1_percent': False, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '63', 'issue': '12', 'first_page': '3918', 'last_page': '3930'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10308', 'display_name': 'Systemic Lupus Erythematosus and Antiphospholipid Syndrome', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10308', 'display_name': 'Systemic Lupus Erythematosus and Antiphospholipid Syndrome', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2745', 'display_name': 'Rheumatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10031', 'display_name': 'Regulatory T Cell Development and Function', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11016', 'display_name': 'Therapeutic Antibodies: Development, Engineering, and Applications', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/belimumab', 'display_name': 'Belimumab', 'score': 0.9798556}, {'id': 'https://openalex.org/keywords/clinical-endpoint', 'display_name': 'Clinical endpoint', 'score': 0.55852336}, {'id': 'https://openalex.org/keywords/b-lymphocyte-depletion', 'display_name': 'B Lymphocyte Depletion', 'score': 0.503193}, {'id': 'https://openalex.org/keywords/post-hoc-analysis', 'display_name': 'Post-hoc analysis', 'score': 0.46973217}], 'concepts': [{'id': 'https://openalex.org/C2781205201', 'wikidata': 'https://www.wikidata.org/wiki/Q1996249', 'display_name': 'Belimumab', 'level': 5, 'score': 0.9798556}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8026507}, {'id': 'https://openalex.org/C27081682', 'wikidata': 'https://www.wikidata.org/wiki/Q269829', 'display_name': 'Placebo', 'level': 3, 'score': 0.7732247}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.6410351}, {'id': 'https://openalex.org/C203092338', 'wikidata': 'https://www.wikidata.org/wiki/Q1340863', 'display_name': 'Clinical endpoint', 'level': 3, 'score': 0.55852336}, {'id': 'https://openalex.org/C2775915377', 'wikidata': 'https://www.wikidata.org/wiki/Q188297', 'display_name': 'Lupus erythematosus', 'level': 3, 'score': 0.5240648}, {'id': 'https://openalex.org/C67761136', 'wikidata': 'https://www.wikidata.org/wiki/Q2105849', 'display_name': 'Post-hoc analysis', 'level': 2, 'score': 0.46973217}, {'id': 'https://openalex.org/C2776912625', 'wikidata': 'https://www.wikidata.org/wiki/Q1485', 'display_name': 'Systemic lupus erythematosus', 'level': 3, 'score': 0.4498493}, {'id': 'https://openalex.org/C168563851', 'wikidata': 'https://www.wikidata.org/wiki/Q1436668', 'display_name': 'Randomized controlled trial', 'level': 2, 'score': 0.4442191}, {'id': 'https://openalex.org/C170286685', 'wikidata': 'https://www.wikidata.org/wiki/Q409346', 'display_name': 'B-cell activating factor', 'level': 4, 'score': 0.40234053}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.36887693}, {'id': 'https://openalex.org/C90924648', 'wikidata': 'https://www.wikidata.org/wiki/Q120569', 'display_name': 'Gastroenterology', 'level': 1, 'score': 0.32487786}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.23157197}, {'id': 'https://openalex.org/C2778453870', 'wikidata': 'https://www.wikidata.org/wiki/Q188930', 'display_name': 'B cell', 'level': 3, 'score': 0.1102888}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.09148872}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.07616642}, {'id': 'https://openalex.org/C204787440', 'wikidata': 'https://www.wikidata.org/wiki/Q188504', 'display_name': 'Alternative medicine', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D053264', 'descriptor_name': 'B-Cell Activating Factor', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D008180', 'descriptor_name': 'Lupus Erythematosus, Systemic', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D008180', 'descriptor_name': 'Lupus Erythematosus, Systemic', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000328', 'descriptor_name': 'Adult', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000974', 'descriptor_name': 'Antibodies, Antinuclear', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000974', 'descriptor_name': 'Antibodies, Antinuclear', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D000911', 'descriptor_name': 'Antibodies, Monoclonal', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D061067', 'descriptor_name': 'Antibodies, Monoclonal, Humanized', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053264', 'descriptor_name': 'B-Cell Activating Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053264', 'descriptor_name': 'B-Cell Activating Factor', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004247', 'descriptor_name': 'DNA', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D004305', 'descriptor_name': 'Dose-Response Relationship, Drug', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004311', 'descriptor_name': 'Double-Blind Method', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008180', 'descriptor_name': 'Lupus Erythematosus, Systemic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008180', 'descriptor_name': 'Lupus Erythematosus, Systemic', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012720', 'descriptor_name': 'Severity of Illness Index', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016896', 'descriptor_name': 'Treatment Outcome', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/art.30613', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S132787887', 'display_name': 'Arthritis & Rheumatism', 'issn_l': '0004-3591', 'issn': ['0004-3591', '1529-0131'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5007058', 'pdf_url': 'https://europepmc.org/articles/pmc5007058?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007058', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/20.500.12648/8249', 'pdf_url': 'https://soar.suny.edu/bitstream/20.500.12648/8249/1/nihms805718.pdf', 'source': None, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/22127708', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc5007058', 'pdf_url': 'https://europepmc.org/articles/pmc5007058?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/16', 'score': 0.61, 'display_name': 'Peace, justice, and strong institutions'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1493773294', 'https://openalex.org/W1920115643', 'https://openalex.org/W1966362133', 'https://openalex.org/W1966632253', 'https://openalex.org/W1975085076', 'https://openalex.org/W1975378201', 'https://openalex.org/W1979972482', 'https://openalex.org/W1984186890', 'https://openalex.org/W2004227465', 'https://openalex.org/W2014956545', 'https://openalex.org/W2039556556', 'https://openalex.org/W2046558944', 'https://openalex.org/W205114876', 'https://openalex.org/W2060208115', 'https://openalex.org/W2069282346', 'https://openalex.org/W2070527591', 'https://openalex.org/W2078800870', 'https://openalex.org/W2089461179', 'https://openalex.org/W2091468965', 'https://openalex.org/W2091675224', 'https://openalex.org/W2096286605', 'https://openalex.org/W2105253459', 'https://openalex.org/W2130077869', 'https://openalex.org/W2131457901', 'https://openalex.org/W2141455950', 'https://openalex.org/W2152330468', 'https://openalex.org/W2167274549', 'https://openalex.org/W2334709721', 'https://openalex.org/W2336764264', 'https://openalex.org/W2414784657', 'https://openalex.org/W2609062584', 'https://openalex.org/W2842267605', 'https://openalex.org/W4241966887'], 'related_works': ['https://openalex.org/W4285613832', 'https://openalex.org/W4229034713', 'https://openalex.org/W3138744424', 'https://openalex.org/W2731175524', 'https://openalex.org/W2145710929', 'https://openalex.org/W2131457901', 'https://openalex.org/W2091468965', 'https://openalex.org/W2042719511', 'https://openalex.org/W1966368095', 'https://openalex.org/W1508090369'], 'abstract_inverted_index': {'To': [0], 'assess': [1], 'the': [2, 5, 45, 57, 100, 160, 244], 'efficacy/safety': [3], 'of': [4, 47, 56, 236], 'B': [6, 141], 'lymphocyte': [7], 'stimulator': [8], 'inhibitor': [9], 'belimumab': [10, 188, 226, 254, 262], 'plus': [11, 17, 156, 283], 'standard': [12, 18, 157, 284], 'therapy': [13, 19, 158, 285], 'compared': [14, 174], 'with': [15, 41, 175, 185, 204, 251], 'placebo': [16, 78, 176], 'in': [20, 49, 65, 119, 146, 303], 'active': [21], 'systemic': [22], 'lupus': [23], 'erythematosus': [24], '(SLE).In': [25], 'a': [26, 66, 116, 166], 'phase': [27], 'III,': [28], 'multicenter,': [29], 'randomized,': [30], 'placebo-controlled': [31], 'trial,': [32], '819': [33], 'antinuclear': [34], 'antibody-positive': [35], 'or': [36, 77], 'anti-double-stranded': [37], 'DNA-positive': [38], 'SLE': [39, 58, 101, 246, 292], 'patients': [40], 'scores': [42], '≥6': [43], 'on': [44, 80, 243], 'Safety': [46], 'Estrogens': [48], 'Lupus': [50, 126], 'Erythematosus': [51], 'National': [52], 'Assessment': [53, 127], '(SELENA)': [54], 'version': [55], 'Disease': [59], 'Activity': [60], 'Index': [61, 103], '(SLEDAI)': [62], 'were': [63, 199, 279], 'randomized': [64], '1:1:1': [67], 'ratio': [68], 'to': [69], 'receive': [70], '1': [71, 138, 186, 206, 252], 'mg/kg': [72, 75, 155, 187, 207, 211, 225, 253, 261], 'belimumab,': [73, 76, 208, 212], '10': [74, 154, 210, 224, 260], 'intravenously': [79], 'days': [81, 90], '0,': [82], '14,': [83], 'and': [84, 86, 134, 143, 202, 209, 233, 259, 268, 277, 295, 298], '28': [85, 89], 'then': [87], 'every': [88], 'for': [91], '72': [92], 'weeks.': [93], 'The': [94, 183], 'primary': [95, 161], 'efficacy': [96, 162], 'end': [97, 163], 'point': [98], 'was': [99, 113, 189, 249, 299], 'Responder': [102], '(SRI)': [104], 'response': [105, 112, 170, 289], 'rate': [106, 184], 'at': [107, 153, 171, 196, 230], 'week': [108, 172, 197], '52': [109, 173, 232], '(an': [110], 'SRI': [111, 169, 288], 'defined': [114], 'as': [115], '≥4-point': [117], 'reduction': [118], 'SELENA-SLEDAI': [120, 221], 'score,': [121, 142], 'no': [122, 135, 144], 'new': [123, 139], 'British': [124], 'Isles': [125], 'Group': [128], '[BILAG]': [129], 'A': [130], 'organ': [131], 'domain': [132], 'score': [133, 150, 222], 'more': [136], 'than': [137], 'BILAG': [140], 'worsening': [145], "physician's": [147], 'global': [148], 'assessment': [149], 'versus': [151, 178], 'baseline).Belimumab': [152], 'met': [159], 'point,': [164], 'generating': [165], 'significantly': [167, 286], 'greater': [168], '(43.2%': [177], '33.5%;': [179], 'P': [180], '=': [181, 192, 257, 265], '0.017).': [182], '40.6%': [190], '(P': [191, 256, 264], '0.089).': [193], 'Response': [194], 'rates': [195], '76': [198, 240], '32.4%,': [200], '39.1%,': [201], '38.5%': [203], 'placebo,': [205], 'respectively.': [213], 'In': [214], 'post': [215], 'hoc': [216], 'sensitivity': [217], 'analyses': [218], 'evaluating': [219], 'higher': [220], 'thresholds,': [223], 'achieved': [227], 'better': [228], 'discrimination': [229], 'weeks': [231, 241], '76.': [234], 'Risk': [235], 'severe': [237, 269, 296], 'flares': [238], 'over': [239], '(based': [242], 'modified': [245], 'Flare': [247], 'Index)': [248], 'reduced': [250, 291], '(34%)': [255], '0.023)': [258], '(23%)': [263], '0.13).': [266], 'Serious': [267], 'adverse': [270], 'events,': [271], 'including': [272], 'infections,': [273], 'laboratory': [274], 'abnormalities,': [275], 'malignancies,': [276], 'deaths,': [278], 'comparable': [280], 'across': [281], 'groups.Belimumab': [282], 'improved': [287], 'rate,': [290], 'disease': [293], 'activity': [294], 'flares,': [297], 'generally': [300], 'well': [301], 'tolerated': [302], 'SLE.': [304]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2136149088', 'counts_by_year': [{'year': 2024, 'cited_by_count': 73}, {'year': 2023, 'cited_by_count': 133}, {'year': 2022, 'cited_by_count': 135}, {'year': 2021, 'cited_by_count': 127}, {'year': 2020, 'cited_by_count': 111}, {'year': 2019, 'cited_by_count': 103}, {'year': 2018, 'cited_by_count': 97}, {'year': 2017, 'cited_by_count': 100}, {'year': 2016, 'cited_by_count': 126}, {'year': 2015, 'cited_by_count': 106}, {'year': 2014, 'cited_by_count': 90}, {'year': 2013, 'cited_by_count': 114}, {'year': 2012, 'cited_by_count': 71}], 'updated_date': '2024-09-10T03:35:52.688901', 'created_date': '2016-06-24'}