Vascular Endothelial Growth Factor Receptor-2 and Neuropilin-1 Form a Receptor Complex That Is Responsible for the Differential Signaling Potency of VEGF165 and VEGF121

Name: Work Video:
Duration: 3 min 30 s
G. Brian Whitaker; Brian J. Limberg; Jan S. Rosenbaum
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'we': [56, 130, 237, 311], 'investigate': [57, 238], 'whether': [58, 239, 1786], 'recently': [60, 241], 'described': [61, 242, 3192, 3693, 3829], 'isoform-specific': [63, 244], 'neuropilin-1': [65, 246, 2983, 3044], '(Npn-1)': [66, 247], 'is': [67, 153, 248, 334, 395, 747, 760, 764, 852, 946, 1582, 1587, 1782, 1936, 2169, 2832, 2843, 3781, 3800, 4385], 'responsible': [68, 154, 249, 335], 'for': [69, 75, 115, 123, 155, 170, 250, 256, 296, 304, 336, 351, 397, 1259, 1944, 1973, 2196, 2643, 2701, 2709, 2826, 3034, 3043, 3068, 3072, 3085, 3288, 3336, 3346, 3375, 4027, 4113, 4192, 4231, 4404, 4420], 'difference': [71, 252, 4382], 'in': [72, 93, 96, 253, 274, 277, 413, 529, 716, 798, 843, 1232, 1302, 1453, 1562, 1574, 1594, 1603, 1606, 1614, 1626, 1629, 1635, 1640, 1699, 1714, 1804, 1880, 1950, 1960, 1975, 2050, 2143, 2150, 2192, 2352, 2380, 2409, 2438, 2452, 2458, 2506, 2603, 2761, 2788, 2904, 3076, 3252, 3278, 3298, 3321, 3378, 3455, 3553, 3588, 3597, 3704, 3735, 3851, 3907, 3962, 3977, 4033, 4044, 4047, 4073, 4105, 4279, 4383, 4435, 4445], 'potency': [73, 158, 254, 339, 4375, 4384], 'observed': [74, 255, 2191], 'these': [76, 164, 257, 345, 1955, 4267], 'ligands.': [77, 258], 'We': [78, 259, 2131, 2154], 'demonstrate': [79, 260, 2132, 2156], 'that': [80, 121, 147, 261, 302, 328, 527, 802, 846, 940, 962, 1119, 1411, 1633, 1938, 1969, 2039, 2082, 2134, 2168, 2172, 2189, 3649, 3696, 4393], 'although': [81, 262, 1556, 2158], 'VEGFR-2': [82, 138, 263, 319, 539, 837, 851, 945, 951, 2068, 2083, 2135, 2176, 2202, 2778, 2928, 3096, 3153, 4028, 4193, 4235, 4277], 'Npn-1': [84, 175, 265, 356, 1153, 1219, 1253, 1310, 1502, 1573, 1593, 1601, 1697, 1798, 1817, 1939, 2047, 2070, 2085, 2142, 2178, 2796, 2850, 2957, 3027, 3061, 3904, 3959, 4042], 'form': [85, 266, 1159, 2138], 'complex,': [87, 129, 268, 310], 'this': [88, 269, 1560, 2182, 2841, 4368], 'complex': [89, 152, 270, 333, 1340, 1418, 2091, 2140, 2160, 2183], 'does': [90, 271, 1813, 2136, 2161, 3165, 3789], 'not': [91, 272, 853, 947, 1155, 1257, 1289, 1566, 1783, 1814, 1877, 1941, 2162, 2845, 3166, 3171, 3742, 3790, 3846], 'an': [94, 119, 178, 275, 300, 359, 456, 2166, 3110, 4373, 4388], 'increase': [95, 276], 'binding': [98, 113, 125, 279, 294, 306, 727, 754, 768, 807, 952, 1316, 3381, 3433, 3457, 3598, 3617, 3652, 3733, 3748, 3810, 4106], 'affinity.': [99, 280, 953], 'Therefore,': [100, 281], 'activity': [103, 284, 769, 842, 1231, 1295, 3343, 4370], 'VEGF121cannot': [107, 288], 'be': [108, 289, 535, 1300, 1942, 3126], 'explained': [109, 290], 'by': [110, 291, 455, 2325, 2622, 2690, 2706, 2719, 2750, 2774, 2815, 2954, 3141, 3180, 3270, 3428, 3448, 3468, 3612, 4015, 4063, 4098, 4151, 4180, 4387], 'affinity': [114, 295, 2167, 2813, 2952, 4230], 'complex.': [117, 298, 1323], 'Using': [118, 299], 'antagonist': [120, 301], 'competes': [122, 303], 'VEGFR-2·Npn-1': [128, 309], 'observe': [131, 312], 'specific': [132, 313, 2697, 3342], 'antagonism': [133, 314], 'VEGF165-meditated': [135, 316], 'phosphorylation': [136, 317, 4437], 'without': [139, 320], 'affecting': [140, 321], 'response.': [143, 324], 'These': [144, 325, 729, 2036, 3010], 'data': [145, 165, 326, 346, 2037, 3811, 3836, 3845, 3849], 'indicate': [146, 327], 'formation': [149, 330, 398, 419, 1616, 2180], 'increased': [157, 338, 4374], 'VEGF165versus': [160, 341], 'VEGF121.': [161, 342, 4380], 'Taken': [162, 343], 'together,': [163, 344], 'suggest': [166, 347, 2038], 'receptor-clustering': [168, 349], 'role': [169, 350, 630, 1558, 1571, 1591], 'Npn-1,': [171, 352, 2633, 2839], 'opposed': [173, 354], 'behaving': [176, 357], 'affinity-converting': [179, 360], 'subunit.': [180, 361], 'neuropilin': [368, 955], 'tyrosine': [370, 466], 'kinase': [371], 'green': [372], 'fluorescent': [373], 'protein': [374, 718, 1518, 1561, 2243, 3113, 3122, 3132, 3181, 3522, 4012], 'placenta': [375, 793], 'human': [378, 3247], 'umbilical': [379, 2340], 'vein': [380, 2341], 'cell': [382, 2354, 2411, 2440, 2692, 2723, 2745, 2780, 3739, 3865], 'bovine': [383, 2229, 2266, 2431], 'serum': [384, 2230, 2267], 'albumin': [385, 2231], 'polyacrylimide': [386], 'gel': [387, 3533], 'electrophoresis': [388, 3534], 'product': [390], 'VEGF-A1': [393], 'gene': [394, 1602], 'required': [396, 1258, 1943], 'embryonic': [401, 407, 451, 1607, 1700, 1885], 'vasculature,': [402], 'because': [403, 1867, 3787], 'haploinsufficiency': [404], 'leads': [405], 'lethality': [408, 1701], 'due': [409, 1800], 'failure': [412], 'both': [414, 2144], 'angiogenesis': [415, 526], 'blood': [417], 'island': [418], '(1Ferrara': [420], 'N.': [421, 541, 640, 668, 693, 868, 992, 2493, 3207, 4250, 4294], 'Carver-Moore': [422], 'K.': [423, 638, 676, 678, 697, 1026, 1094, 1896, 1997, 2487, 2489, 3225, 3235], 'Chen': [424, 633, 861, 1375, 3200, 4243, 4287], 'H.': [425, 601, 634, 860, 862, 864, 890, 892, 1058, 1176, 1354, 1376, 1469, 1658, 1686, 1727, 1729, 1767, 3199, 3201, 3203, 3231, 4242, 4244, 4246, 4286, 4288, 4290, 4316, 4318], 'Dowd': [426], 'M.': [427, 473, 507, 511, 670, 674, 680, 894, 922, 974, 1046, 1054, 1090, 1164, 1172, 1265, 1392, 1646, 1648, 1652, 1682, 1740, 1827, 1910, 2011, 2101, 2119, 2481, 2491, 2852, 2856, 2887, 4320, 4348], 'Lu': [428], 'L.': [429, 433, 580, 597, 858, 994, 1372, 1532, 1918, 2019, 3197, 3233, 4240, 4284], "O'Shea": [430], 'K.S.': [431], 'Powell-Braxton': [432], 'Hillan': [434], 'K.J.': [435], 'Moore': [436], 'M.W.': [437], 'Nature.': [438, 476, 514, 1434, 1772], '1995;': [439, 477, 515, 1435, 1731], '121:': [440, 1732], '1089-1098Google': [441], 'Scholar).': [442, 713, 787, 830, 1147, 1218, 1248, 1408, 1497, 1693, 1751, 2035, 2130, 2502, 2926, 3009, 3241, 3825, 4364], 'development': [448, 1628, 1882, 1946, 1976, 1987], 'vasculature': [452, 1886, 1949, 1980], 'mediated': [454, 536], 'interaction': [457], 'with': [458, 625, 720, 838, 1609, 1703, 2046, 2141, 2165, 2419, 2569, 2627, 2666, 2756, 2783, 3168, 3372, 3430, 3450, 3470, 3479, 3510, 3614, 3623, 3808, 3984, 4030, 4085, 4100, 4122, 4138, 4148, 4163, 4221, 4440], '(VEGFR)-1': [462], '-2': [464], 'kinases': [467], '(2Fong': [468], 'G.H.': [469, 486], 'Rossant': [470, 502], 'J.': [471, 492, 503, 551, 553, 636, 641, 698, 779, 869, 895, 923, 996, 1061, 1095, 1132, 1179, 1203, 1490, 1523, 1850, 2483, 2913, 3208, 3817, 4251, 4295, 4321, 4349], 'Gertsenstein': [472, 506], 'Breitman': [474, 510], 'M.L.': [475, 1386, 2854, 2875], '376:': [478, 516, 1436], '66-70Crossref': [479], 'PubMed': [480, 497, 518, 572, 587, 650, 660, 687, 709, 783, 826, 880, 906, 934, 984, 1005, 1039, 1072, 1106, 1143, 1190, 1214, 1244, 1281, 1366, 1404, 1438, 1481, 1495, 1528, 1551, 1668, 1691, 1734, 1747, 1776, 1837, 1861, 1930, 2031, 2111, 2126, 2500, 2861, 2898, 2924, 3005, 3219, 3821, 4262, 4306, 4332, 4360], 'Scopus': [481, 519, 573, 588, 661, 688, 710, 784, 827, 881, 907, 935, 985, 1040, 1073, 1107, 1144, 1191, 1215, 1245, 1282, 1367, 1405, 1439, 1482, 1552, 1669, 1748, 1777, 1838, 1862, 1931, 2032, 2112, 2127, 2862, 2899, 3006, 3220, 3822, 4263, 4307, 4333, 4361], '(2204)': [482], 'Google': [483, 498, 521, 558, 575, 590, 623, 651, 663, 690, 712, 786, 829, 883, 909, 937, 987, 1006, 1042, 1075, 1109, 1146, 1193, 1217, 1247, 1284, 1369, 1407, 1441, 1484, 1496, 1529, 1554, 1671, 1692, 1735, 1750, 1779, 1840, 1864, 1933, 2034, 2114, 2129, 2501, 2864, 2901, 2925, 3008, 3222, 3240, 3824, 4265, 4309, 4335, 4363], 'Scholar,': [484, 499, 559, 576, 591, 652, 664, 691, 884, 910, 988, 1194, 1370, 1485, 1530, 1672, 1736, 1841, 2115, 3223, 4310, 4336], '3Fong': [485], 'Zhang': [487], 'L.Y.': [488], 'Bryce': [489], 'D.M.': [490], 'Peng': [491], 'Development.': [493, 1687, 1730], '1999;': [494, 569, 584, 620, 780, 1002, 1036, 1098, 1358, 1396, 1473, 1525, 1688, 1927, 2028], '126:': [495, 1689], '3015-3025Crossref': [496], '4Shalaby': [500], 'F.': [501, 543, 1263, 1346, 1429, 1461, 1916, 2017], 'Yamaguchi': [504, 917, 4343], 'T.': [505, 773, 1012, 1024, 1080, 1084, 1127, 1198, 1267, 1342, 1457, 1644, 1650, 1656, 1674, 1676, 1684, 1721, 1845], 'Wu': [508], 'X.': [509, 1534], 'Schuh': [512], 'A.C.': [513], '62-66Crossref': [517], '(3337)': [520], 'Scholar),': [522, 624, 938, 1007, 1043, 1076, 1110, 1285, 1555, 1780, 1934, 2865, 4266], 'whereas': [523, 756, 1111], 'occur': [528, 1634], 'adult': [531], 'animal': [532], 'appear': [533, 1329], 'largely': [537], 'through': [538, 2071, 4130], '(5Ortega': [540], 'Jonca': [542], 'Vincent': [544], 'S.': [545, 666, 775, 886, 888, 912, 918, 966, 968, 1034, 1050, 1088, 1168, 1374, 1546, 1819, 1821, 2093, 2095, 2883, 2885, 2893, 4312, 4314, 4338, 4344], 'Favard': [546], 'C.': [547, 599, 1020], 'Ruchoux': [548], 'M.M.': [549, 1390], 'Plouet': [550, 995], 'Am.': [552], 'Pathol.': [554], '1997;': [555, 823, 898, 1492, 1660, 2997, 4324], '151:': [556], '1215-1224PubMed': [557], '6Machein': [560], 'M.R.': [561], 'Risau': [562, 610], 'W.': [563, 611, 1912, 2013], 'Plate': [564], 'K.H.': [565], 'Hum.': [566], 'Gene': [567], 'Ther.': [568], '10:': [570, 1242], '1117-1128Crossref': [571], '(67)': [574], '7Zhu': [577], 'Z.P.': [578], 'Witte': [579], 'Invest.': [581], 'New': [582], 'Drug.': [583], '17:': [585, 1493], '195-212Crossref': [586], '(94)': [589], '8Fong': [592], 'T.A.': [593], 'Shawver': [594], 'L.K.': [595], 'Sun': [596], 'Tang': [598], 'App': [600], 'Powell': [602], 'T.J.': [603], 'Kim': [604], 'Y.H.': [605, 810], 'Schreck': [606], 'R.': [607, 866, 990, 1056, 1174, 3205, 4248, 4292], 'Wang': [608, 1347, 1462], 'X.Y.': [609], 'Ullrich': [612], 'A.': [613, 816, 914, 916, 1022, 1035, 1052, 1170, 1344, 1384, 1459, 1547, 1723, 1725, 1914, 2015, 2894, 4340, 4342], 'Hirth': [614], 'K.P.': [615], 'McMahon': [616], 'G.': [617, 771, 972, 1060, 1131, 1178, 1202, 1536, 1825, 1849, 1894, 1995, 2099, 2908, 3229], 'Cancer': [618, 1741, 2120], 'Res.': [619, 821], '59:': [621], '99-106PubMed': [622], 'VEGFR-1': [626, 3169], 'playing': [627], 'modulatory': [629], '(9Park': [631], 'J.E.': [632], 'Winer': [635], 'Houck': [637], 'Ferrara': [639, 867, 3206, 4249, 4293], 'Biol.': [642, 699, 870, 896, 924, 1062, 1096, 1133, 1180, 1204, 1851, 2496, 2914, 3209, 4252, 4296, 4322, 4350], 'Chem.': [643, 700, 871, 897, 925, 1063, 1097, 1134, 1181, 1205, 1852, 2915, 3210, 4253, 4297, 4323, 4351], '1994;': [644, 3237], '269:': [645], '25646-25654Abstract': [646], 'Full': [647, 704, 706, 875, 877, 901, 903, 929, 931, 979, 981, 1067, 1069, 1101, 1103, 1138, 1140, 1185, 1187, 1209, 1211, 1276, 1278, 1361, 1363, 1399, 1401, 1476, 1478, 1663, 1665, 1832, 1834, 1856, 1858, 2106, 2108, 2919, 2921, 3000, 3002, 3214, 3216, 4257, 4259, 4301, 4303, 4327, 4329, 4355, 4357], 'Text': [648, 705, 707, 876, 878, 902, 904, 930, 932, 980, 982, 1068, 1070, 1102, 1104, 1139, 1141, 1186, 1188, 1210, 1212, 1277, 1279, 1362, 1364, 1400, 1402, 1477, 1479, 1664, 1666, 1833, 1835, 1857, 1859, 2107, 2109, 2920, 2922, 3001, 3003, 3215, 3217, 4258, 4260, 4302, 4304, 4328, 4330, 4356, 4358], 'PDF': [649, 708, 879, 905, 933, 983, 1071, 1105, 1142, 1189, 1213, 1280, 1365, 1403, 1480, 1667, 1836, 1860, 2110, 2923, 3004, 3218, 4261, 4305, 4331, 4359], '10Carmeliet': [653], 'P.': [654, 814, 1431, 1888, 1989, 2311, 2485], 'Nat.': [655], 'Med.': [656, 1926, 2027], '2000;': [657, 684, 701, 1135, 1206, 1241, 1744, 1853, 2123, 2858, 2895, 2916], '6:': [658], '389-395Crossref': [659], '(3432)': [662], '11Kanno': [665], 'Oda': [667], 'Abe': [669], 'Terai': [671], 'Y.': [672, 682, 920, 1129, 1200, 1350, 1427, 1465, 1654, 1678, 1680, 1847, 2479, 4346], 'Ito': [673], 'Shitara': [675], 'Tabayashi': [677], 'Shibuya': [679, 921, 1053, 1171, 4347], 'Sato': [681], 'Oncogene.': [683, 3236], '19:': [685, 1526, 1661, 1745, 2124], '2138-2146Crossref': [686], '(255)': [689], '12Rahimi': [692], 'Dayanir': [694], 'V.': [695, 1000, 1906, 2007], 'Lashkari': [696], '275:': [702, 1136, 1207, 1854, 2917], '16986-16992Abstract': [703], '(197)': [711], 'exists': [715, 797], 'multiple': [717, 3864], 'different': [721, 800], 'heparin': [722, 753, 767, 806, 3394, 3603, 4111], 'proteoglycan': [723], 'extracellular': [725, 2835, 3019, 3097], 'matrix': [726], 'properties.': [728], '(VEGF165,': [731], 'VEGF121,': [732, 1151], 'VEGF145,': [733], 'VEGF183,': [734], 'VEGF189,': [735], 'VEGF206)': [737], 'arise': [738], 'from': [739, 1965, 2209, 2220, 2238, 2248, 2261, 2270, 2282, 2294, 2308, 2336, 2346, 2370, 2402, 2833, 3047, 3106, 3176, 3338, 3351, 3863, 4214], 'alternate': [740], 'predominant': [749], 'isoform': [750, 759, 1875], 'has': [752, 1113, 1503, 1565, 2867], 'activity,': [755], 'freely': [761], 'soluble': [762, 2849], 'devoid': [765], '(13Neufeld': [770], 'Cohen': [772, 1126, 1197, 1844], 'Gengrinovitch': [774], 'Poltorak': [776], 'Z.': [777, 1125, 1196, 1487, 1843, 2879], 'FASEB': [778, 3816], '13:': [781], '9-22Crossref': [782], '(3135)': [785], 'Similarly,': [788], 'another': [789], 'superfamily': [791], 'member,': [792], '(PlGF),': [796], 'three': [799], 'also': [803, 1222, 1758], 'exhibit': [804, 1878, 1958, 4270], '(14Cao': [809], 'Ji': [811], 'W.D.R.': [812], 'Qi': [813], 'Rosin': [815], 'Cao': [817], 'Y.M.': [818], 'Biochem.': [819], 'Biophys.': [820], 'Commun.': [822], '235:': [824], '493-498Crossref': [825], '(153)': [828], 'Although': [831, 1569, 4224], 'bind': [835, 1156, 1223, 1507, 1815, 2066, 2163, 2871], 'equal': [839], 'affinity,': [840, 3686], 'their': [841, 941], 'biochemical': [844], 'assays': [845], 'rely': [847], 'activation': [849, 1420, 1444], 'equivalent': [854], '(15Keyt': [855, 3194, 4237, 4281], 'B.A.': [856, 3195, 4238, 4282], 'Berleau': [857, 3196, 4239, 4283], 'Nguyen': [859, 3198, 4241, 4285], 'Heinsohn': [863, 3202, 4245, 4289], 'Vandlen': [865, 3204, 4247, 4291], '1996;': [872, 1773, 3211, 4254, 4298], '271:': [873, 3212, 4255, 4299], '7788-7795Abstract': [874, 3213, 4256, 4300], '(530)': [882, 3221, 4264, 4308], '16Soker': [885, 4311], 'Gollamudi-Payne': [887, 4313], 'Fidder': [889, 4315], 'Charmahelli': [891, 4317], 'Klagsbrun': [893, 973, 1089, 1739, 1826, 2100, 2118, 2855, 2886, 4319], '272:': [899, 4325], '31582-31588Abstract': [900, 4326], '(169)': [908, 4334], '17Ogawa': [911, 4337], 'Oku': [913, 4339], 'Sawano': [915, 4341], 'Yazaki': [919, 4345], '1998;': [926, 976, 1064, 1182, 1273, 1548, 1829, 2103, 4352], '273:': [927, 1065, 1183, 4353], '31273-31282Abstract': [928, 4354], '(330)': [936, 4362], 'implying': [939, 1968], 'solely': [948], 'dependent': [949], 'Recently,': [954], '(Npn)-1': [956], 'was': [957, 2207, 2218, 2268, 2306, 2323, 2558, 2620, 2648, 2717, 2748, 2801, 2933, 2962, 2975, 3031, 3045, 3065, 3102, 3123, 3133, 3185, 3250, 3267, 3304, 3325, 3344, 3426, 3446, 3466, 3504, 3582, 3610, 3690, 3837, 4013], 'identified': [958, 1115, 2729], 'binds': [963, 1120, 1150], '(18Soker': [965, 1818, 2092], 'Takashima': [967, 1820, 2094, 2882], 'Miao': [969, 1822, 2096, 2880], 'H.Q.': [970, 1738, 1823, 2097, 2117, 2881], 'Neufeld': [971, 1059, 1130, 1177, 1201, 1824, 1848, 2098], 'Cell.': [975, 1357, 1395, 1472, 1828, 2102, 2495, 2996], '92:': [977, 1830, 2104], '735-745Abstract': [978, 1831, 2105], '(2066)': [986, 1839, 2113], '19Tordjman': [989], 'Ortega': [991], 'Coulombel': [993], 'Romeo': [997], 'P.H.': [998], 'Lemarchandel': [999], 'Blood.': [1001], '94:': [1003], '2301-2309Crossref': [1004], 'VEGF-E': [1008], '(20Wise': [1009], 'L.M.': [1010], 'Veikkola': [1011], 'Mercer': [1013], 'A.A.': [1014], 'Savory': [1015], 'L.J.': [1016], 'Fleming': [1017], 'S.B.': [1018], 'Caesar': [1019], 'Vitali': [1021], 'Makinen': [1023], 'Alitalo': [1025, 1093, 3234], 'Stacker': [1027], 'S.A.': [1028], 'Proc.': [1029, 1541, 2888], 'Natl.': [1030, 1542, 2889], 'Acad.': [1031, 1543, 2890], 'Sci.': [1032, 1544, 2891], 'U.': [1033, 1086, 1092, 1545, 2892], '96:': [1037], '3071-3076Crossref': [1038], '(231)': [1041], 'PlGF152': [1044, 2316], '(21Migdal': [1045, 1163], 'Huppertz': [1047, 1165], 'B.': [1048, 1082, 1166, 1538], 'Tessler': [1049, 1167], 'Comforti': [1051, 1169], 'Reich': [1055, 1173], 'Baumann': [1057, 1175], '22272-22278Abstract': [1066, 1184], '(278)': [1074, 1192], 'VEGF-B': [1078], '(22Makinen': [1079], 'Olofsson': [1081], 'Karpanen': [1083], 'Hellman': [1085], 'Soker': [1087, 2884], 'Eriksson': [1091], '274:': [1099], '21217-21222Abstract': [1100], '(230)': [1108], 'Npn-2': [1112, 1221, 1255, 1312], 'PlGF152,': [1121], 'VEGF165,': [1122], 'VEGF145(23Gluzman-Poltorak': [1124], 'Herzog': [1128, 1199, 1846], '18040-18045Abstract': [1137, 1208, 1855], '(306)': [1145, 1216, 1863], 'Neither': [1148], 'Npn': [1149], 'will': [1154, 3056], 'non-heparin-binding': [1158], 'PlGF,': [1161], 'PlGF139': [1162], '23Gluzman-Poltorak': [1195, 1842], 'various': [1224], 'semaphorin': [1225, 1260, 1320, 1338, 1563, 1754, 1806], 'ligands': [1226, 3596, 4269], 'mediate': [1228], 'repulsive': [1229], 'guidance': [1230, 1719], 'certain': [1233], 'neuronal': [1234, 1577, 1641, 1718], 'populations': [1235], '(24Raper': [1236], 'J.A.': [1237, 1765], 'Curr.': [1238], 'Opin.': [1239], 'Neurobiol.': [1240], '88-94Crossref': [1243], '(402)': [1246], 'cytoplasmic': [1250], 'domains': [1251], 'signaling': [1261, 1306, 1321, 1334, 1517, 1564, 1802, 2052], '(25Nakamura': [1262], 'Tanaka': [1264], 'Takahashi': [1266], 'Kalb': [1268, 1351, 1466], 'R.G.': [1269, 1352, 1467], 'Strittmatter': [1270, 1355, 1430, 1432, 1470, 1488], 'S.M.': [1271, 1356, 1433, 1471, 1489], 'Neuron.': [1272, 1659], '21:': [1274], '1093-1100Abstract': [1275], '(240)': [1283], 'they': [1287], 'do': [1288, 1876], 'contain': [1290, 3898, 3953], 'sequences': [1291, 1297], 'predictive': [1292], 'enzymatic': [1294], 'nor': [1296], 'predicted': [1298, 2846], 'involved': [1301, 1452], 'coupling': [1303], 'intracellular': [1305], 'molecules.': [1307], 'Nevertheless,': [1308], 'proteins': [1313], 'obligate': [1315], 'subunits': [1317, 1335], 'Members': [1324], 'plexin': [1327], 'family': [1328, 2523], 'serve': [1331], '(26Takahashi': [1341, 1456], 'Fournier': [1343, 1458], 'Nakamura': [1345, 1428, 1460], 'L.H.': [1348, 1463], 'Murakami': [1349, 1464], 'Fujisawa': [1353, 1468, 1657, 1685, 1728, 2482], '99:': [1359, 1397, 1474], '59-69Abstract': [1360, 1475], '(703)': [1368, 1483], '27Tamagnone': [1371], 'Artigiani': [1373], 'He': [1377], 'Z.G.': [1378], 'Ming': [1379], 'G.L.': [1380], 'Song': [1381], 'H.J.': [1382, 3813], 'Chedotal': [1383], 'Winberg': [1385], 'Goodman': [1387], 'C.S.': [1388], 'Poo': [1389], 'TessierLavigne': [1391], 'Comoglio': [1393], 'P.M.': [1394], '71-80Abstract': [1398], '(938)': [1406], 'Potential': [1409], 'signals': [1410], 'lie': [1412], 'downstream': [1413], 'neuropilin-plexin': [1416], 'include': [1419], 'pertussis': [1423], 'toxin-sensitive': [1424], 'G-protein': [1425, 1451, 1516], '(28Goshima': [1426], '509-514Crossref': [1437], '(634)': [1440], 'Scholar)': [1442, 1865, 2902], 'Rac1,': [1446], 'small': [1448], 'molecular': [1449], 'mass': [1450], 'cytoskeletal': [1454], 'rearrangement': [1455], '29Jin': [1486], 'Neurosci.': [1491, 1524], '6256-6263Crossref': [1494], 'carboxyl': [1499], 'terminus': [1500], 'shown': [1505], 'PSD-95/Dlg/ZO': [1510], 'domain': [1511, 2948, 3016, 3098], 'containing': [1512, 2474, 2546, 2551, 2669, 3391, 3600, 3629, 4108, 4125], 'regulator': [1514], '(30Cai': [1519], 'H.B.': [1520], 'Reed': [1521], 'R.R.': [1522], '6519-6527Crossref': [1527], '31DeVries': [1531], 'Lou': [1533], 'Zhao': [1535], 'Zheng': [1537], 'Farquhar': [1539], 'M.G.': [1540], '95:': [1549], '12340-12345Crossref': [1550], '(187)': [1553], 'established.': [1568], 'mediating': [1575], 'semaphorins': [1581], 'being': [1583, 3577], 'elucidated,': [1584], 'much': [1585], 'less': [1586], 'known': [1588, 1785, 3801], 'about': [1589], 'VEGF165-mediated': [1595], 'angiogenesis.': [1596], 'Targeted': [1597], 'disruption': [1598], 'mice': [1604, 1868, 1957], 'results': [1605, 1698, 3862], 'lethality,': [1608], 'embryos': [1611], 'exhibiting': [1612], 'defects': [1613, 1625, 1639, 1713, 1959], 'brachial': [1618], 'arch-derived': [1619], 'vessels,': [1620], 'impaired': [1621], 'neural': [1622], 'vascularization,': [1623], 'yolk': [1631], 'sac': [1632], 'addition': [1636], 'expected': [1638], 'patterning': [1642], '(32Kitsukawa': [1643], 'Shimizu': [1645], 'Sanbo': [1647, 1681], 'Hirata': [1649], 'Taniguchi': [1651], 'Bekku': [1653, 1677], 'Yagi': [1655, 1683], '995-1005Abstract': [1662], '(559)': [1670], '33Kawasaki': [1673], 'Kitsukawa': [1675], 'Matsuda': [1679], '4895-4902Crossref': [1690], 'Transgenic': [1694], 'overexpression': [1695, 1796], 'associated': [1702, 3807], 'excessive': [1704], 'formation,': [1706], 'dilation,': [1707], 'hemorrhaging,': [1709], 'well': [1711, 2148], 'skeletal': [1715], 'morphogenesis': [1716], '(34Kitsukawa': [1720], 'Shimono': [1722], 'Kawakami': [1724], 'Kondoh': [1726], '4309-4318Crossref': [1733], '35Miao': [1737, 2116], 'Metastasis': [1742, 2121], 'Rev.': [1743, 2122], '29-37Crossref': [1746, 2125], '(96)': [1749, 2128], 'Because': [1752, 1811], 'III': [1755], 'knockout': [1756], 'mouse': [1757], 'exhibits': [1759], 'cardiovascular': [1760], 'abnormalities': [1761], '(36Behar': [1762], 'O.': [1763, 3227], 'Golden': [1764], 'Mashimo': [1766], 'Schoen': [1768], 'F.J.': [1769], 'Fishman': [1770], 'M.C.': [1771], '383:': [1774], '525-528Crossref': [1775], '(509)': [1778], 'it': [1781, 1935, 3788], 'currently': [1784], 'attributed': [1790], 'absence': [1793, 3709], 'or': [1794, 1807, 2177, 2550, 2589, 2634, 2683, 2705, 2903, 3517, 3707, 4041, 4055], 'alterations': [1803], 'systems.': [1810], 'engineered': [1869], 'express': [1871], 'only': [1872, 3025, 3057], 'deficiencies': [1879], '(37Carmeliet': [1887, 1988], 'Ng': [1889, 1990], 'Y.S.': [1890, 1991], 'Nuyens': [1891, 1992], 'D.': [1892, 1920, 1993, 2021], 'Theilmeier': [1893, 1994], 'Brusselmans': [1895, 1996], 'Cornelissen': [1897, 1998], 'I.': [1898, 1904, 1999, 2005], 'Ehler': [1899, 2000], 'E.': [1900, 2001], 'Kakkar': [1901, 2002], 'V.V.': [1902, 2003], 'Stalmans': [1903, 2004], 'Mattot': [1905, 2006], 'Perriard': [1907, 2008], 'J.C.': [1908, 2009], 'Dewerchin': [1909, 2010], 'Flameng': [1911, 2012], 'Nagy': [1913, 2014], 'Lupu': [1915, 2016], 'Moons': [1917, 2018], 'Collen': [1919, 2020], 'Damore': [1921, 2022], 'P.A.': [1922, 2023], 'Shima': [1923, 2024], 'D.T.': [1924, 2025], 'Nature': [1925, 2026], '5:': [1928, 2029], '495-502Crossref': [1929, 2030], '(558)': [1932, 2033], 'possible': [1937], 'might': [1940], 'response': [1951, 4396], 'VEGF-A.': [1953], 'However,': [1954], 'same': [1956, 2638, 4229], 'cardiac': [1961, 1979, 1986, 2059], 'vascularization': [1962], 'suffer': [1964], 'ischemic': [1966], 'cardiomyopathy,': [1967], 'cannot': [1971], 'substitute': [1972], 'during': [1981], 'period': [1983], 'postnatal': [1985], 'inability': [2041], 'interact': [2045], 'may': [2048, 2086], 'insufficient': [2051], 'support': [2054], 'maturation': [2056], 'vasculature.': [2060], 'distinct': [2072], 'regions': [2073], 'molecule': [2077], 'led': [2078], 'assertion': [2081], 'signal': [2087], 'co-receptor': [2090], 'here': [2133], 'indeed': [2137], 'heterologous': [2145], 'systems': [2146], 'cultured': [2151, 2193, 2351, 2379, 2408, 2437], 'further': [2155], 'that,': [2157], 'greater': [2170, 3933, 3969], 'than': [2171], 'exhibited': [2173], 'either': [2175], 'alone,': [2179], 'can': [2184], 'explain': [2185], 'potencies': [2188], 'cells': [2195, 2343, 2368, 2400, 2435, 2446, 2565, 2612, 2626, 2658, 2680, 2704, 2735, 2755, 2770, 3108, 3369, 3476, 3620, 3897, 3952, 4066, 4082], 'VEGF165-': [2197], 'VEGF121-mediated': [2199], 'stimulation': [2200], 'activation.': [2203], 'Carrier-free': [2204], 'recombinant': [2205, 3248], 'purchased': [2208, 2219, 2237, 2247, 2260, 2269, 3046], 'R': [2210], '&': [2211], 'D': [2212], 'Systems': [2213], 'Inc.': [2214, 2264, 3051], '(Minneapolis,': [2215], 'MN).': [2216], 'Na125I': [2217, 3266], 'Amersham': [2221, 2249], 'Pharmacia': [2222, 2250], 'Biotech.Heparin': [2223], 'sulfate': [2224, 3395, 3604, 4112], '(catalog': [2225, 2233, 3040], 'number': [2226, 2234, 2958, 3041, 3684, 3746, 4058, 4176], '9399)': [2227], '(BSA)': [2232], 'A3294)': [2235], 'were': [2236, 2246, 2259, 2280, 2292, 2334, 2350, 2359, 2378, 2407, 2436, 2447, 2466, 2516, 2566, 2613, 2664, 2687, 2737, 2772, 3139, 3174, 3360, 3370, 3477, 3527, 3540, 3557, 3621, 3665, 3702, 3756, 3982, 4025, 4067, 4083, 4120, 4136, 4161, 4183, 4202, 4212], 'Sigma.': [2239], 'PD-10': [2240, 3334], 'columns': [2241], 'G-Sepharose': [2244, 3523], 'beads': [2245], 'Biotech.': [2251], 'Donor': [2252], 'calf': [2253, 2390], 'serum,': [2254, 2391], 'LipofectAMINE-2000,': [2255], 'Optimem': [2257, 2604], 'I': [2258, 2605], 'Life': [2262], 'Technologies,': [2263], 'Fetal': [2265], 'Hyclone': [2271], 'Laboratories': [2272], '(Logan,': [2273], 'UT).': [2274], 'pJFE14': [2275, 2473, 2570], 'vector': [2276, 2299], 'hVEGFR-2/pJFE14': [2278], 'construct': [2279, 2302, 2305, 2631], 'obtained': [2281, 2293, 2307, 2335, 2345, 2369, 2401, 3757], 'Regeneron': [2283, 2295], 'Pharmaceuticals': [2284], '(Tarrytown,': [2285], 'NY).': [2286], 'pLTRMCSIRES-GFP': [2287, 2528], 'pLTR2hFLK1(full)IRES-GFP': [2289], 'retroviral': [2290, 2304, 2525, 2630], 'constructs': [2291, 2537, 2600], 'Pharmaceuticals.': [2296], 'pBMN-Z-I-Neo': [2298, 2562], 'used': [2300, 2360, 2738, 2825, 3032], 'hNpn-1': [2303, 2464, 2556, 2590, 2594, 2757, 2784], 'Dr.': [2309, 2967], 'Gary': [2310], 'Nolan': [2312], '(Stanford': [2313], 'University).': [2314, 2972], 'Exon': [2317], '6': [2318, 2670], 'peptide': [2319, 2806, 2938], '(amino': [2320, 2809, 2941, 3099], 'acids': [2321, 2810, 2942, 2979, 3100], '142–157)': [2322], 'synthesized': [2324], 'SynPep': [2326], '(Dublin,': [2327], 'CA).': [2328, 3549, 3677], 'All': [2329, 2443], 'other': [2332], 'reagents': [2333], 'commercial': [2337], 'sources.': [2338], 'Human': [2339], '(HUVEC)': [2344], 'Clonetics': [2347], '(Walkersville,': [2348], 'MD)': [2349], 'medium': [2356, 2383, 2413, 2417, 2639], '(Clonetics)': [2357], 'up': [2361], 'passage': [2363], '3.': [2364], 'Balb/c': [2365, 2381, 2507, 2655, 2677, 2752, 3951], '3T3': [2366, 2508, 2656, 2678, 2753], 'A31': [2367, 2509, 2657, 2679, 2754], 'American': [2372, 2403], 'Type': [2373, 2404], 'Culture': [2374, 2405], 'Collection': [2375, 2406], '(Manassas,': [2376], 'VA)': [2377], "(Dulbecco's": [2384, 2414], 'modified': [2385, 2415, 4087], "Eagle's": [2386, 2416, 4088], 'medium,': [2387, 3385, 3437, 4089], '10%': [2388, 2429], 'donor': [2389], '1%l-glutamine,': [2392], '1%': [2393, 2395, 2420, 2422, 2426, 3501], 'antimycotics,': [2394, 2427], 'nonessential': [2396, 2423], 'amino': [2397, 2424, 2978], 'acids).': [2398], 'COS-1': [2399, 2410, 2439, 2459, 2564, 2645], 'supplemented': [2418], 'l-glutamine,': [2421], 'acids,': [2425], 'fetal': [2430], 'serum).': [2432], 'QMXE': [2433, 2624], 'packaging': [2434, 2625], 'medium.': [2442], 'grown': [2448], '37': [2450, 4093, 4117], '°C': [2451, 3380, 3509], '5%': [2453, 2653, 4031], 'CO2.': [2454], 'For': [2455, 2503, 3080, 3678], 'transient': [2456], 'transfection': [2457], 'cells,': [2460, 2510], 'hVEGFR-2': [2462, 2573, 2577, 2583, 2682, 2696, 2714, 2722], 'cDNAs': [2465, 2515], 'cloned': [2467], 'into': [2468, 2520, 2560], 'mammalian': [2470], 'expression': [2471, 2505], 'plasmid': [2472], 'SRα': [2476], 'promoter': [2477], '(38Takebe': [2478], 'Seiki': [2480], 'Hoy': [2484], 'Yokota': [2486], 'Arai': [2488, 2492], 'Yoshida': [2490], 'Mol.': [2494], '1988;': [2497], '8:': [2498], '466-472Crossref': [2499], 'stable': [2504, 2769, 2777], 'hVEGFR-2,': [2511], 'GFP,': [2512], 'hNeuropilin-1': [2514, 2743], 'generated': [2517, 2621, 2649, 2718, 2749, 2976, 4220], 'subcloned': [2519, 2559], 'pBMN-Z': [2522, 2544], 'vectors.': [2526], '(referred': [2529], 'Mock': [2533, 2711, 2734], 'vector)': [2534], 'pLTRhFLK1(full)IRES-GFP': [2536], 'bi-cistronic': [2540], 'modification': [2541, 3189], 'vector,': [2545], 'GFP': [2548, 2552, 2684, 2707], 'marker': [2549], '+': [2553, 2578, 2586, 2595], 'hVEGFR-2.': [2554], 'cDNA': [2557], 'vector.': [2563], 'transiently': [2567], 'transfected': [2568], '(7.0': [2571], 'μg),': [2572, 2588], '(5.0': [2574, 2584], 'μg': [2575, 2580, 2592, 2597, 3244, 3512], '2.0': [2579], 'pJFE14),': [2582], 'μg)': [2585, 4142], 'hNpn-1(2.0': [2587], '(2.0': [2591], '5.0': [2596], 'pJFE14)': [2599], 'using': [2601, 2636, 2694, 3144, 3187, 3634, 3667, 3758, 4050, 4196, 4204], 'LipofectAMINE-2000': [2602], 'according': [2606], "manufacturer's": [2609], 'instructions.': [2610], 'plated': [2614, 3361, 3558, 4068], '20': [2615, 3320, 4038], 'h': [2616, 3363, 3377, 3560], 'after': [2617], 'transfection.': [2618], 'Retrovirus': [2619], 'transfecting': [2623], 'appropriate': [2629], '(VEGFR-2,': [2632], 'Mock)': [2635], 'methodology': [2641, 3780], 'established': [2642], 'Virus': [2647], 'overnight': [2650, 3506, 4143], '(33°': [2651], 'C,': [2652], 'CO2).': [2654], '(∼1': [2659], '×': [2660, 3357, 3551, 3875, 3881, 3887, 3893, 3915, 3922, 3929, 3941, 3947, 4070, 4408, 4424], '106': [2661, 4071], 'cells/100-mm': [2662], 'dish)': [2663], 'infected': [2665, 2676], 'viral': [2667], 'supernatants': [2668, 3148], 'μg/ml': [2671, 3393, 3400, 3403, 3406, 3409, 3415, 3418, 3602, 4110, 4165], 'polybrene.': [2673], 'Pools': [2674], 'expressing': [2681], 'alone': [2685, 2873], '(Mock)': [2686], 'selected': [2688, 2787], 'twice': [2689], 'fluorescence-activated': [2691], 'sorting': [2693], 'monoclonal': [2698, 3088, 3154], 'antibody': [2699, 2799, 2831, 2842, 2931, 2961, 2974, 3030, 3039, 3064, 3071, 3155, 3514, 4140, 4168], 'J5F4A2': [2700, 3087], 'hVEGFR-2-containing': [2703], 'emission': [2708], 'clone': [2715], '(D7R2)': [2716, 2782], 'subjecting': [2720], 'pool': [2724], 'limiting': [2726], 'dilution': [2727], 'via': [2730], 'Western': [2731, 3035, 3142, 3908, 3963], 'analysis.': [2732], '(PGBMGH)': [2736], 'pool.': [2741], 'clonal': [2744, 2779], 'line': [2746, 2781], '(Npn-1(2))': [2747], 'infecting': [2751, 2775], 'virus': [2758, 2785], 'selecting': [2760], 'presence': [2763, 2790, 3590, 3706], '1.5–2.0': [2765, 2792], 'mg/ml': [2766, 2793], 'Geneticin.': [2767, 2794], 'hVEGFR-2/hNpn-1': [2768], '(D7R2·Npn-1(4))': [2771], 'created': [2773], 'rabbit': [2797, 2929, 4051, 4056], 'polyclonal': [2798, 2930, 2960], '(NP1ECD4)': [2800], 'raised': [2802, 2934], 'against': [2803, 2935, 2977], 'purified': [2805, 2814, 2937, 2953, 3105, 3121, 3150, 3175, 4234], 'sequence': [2807, 2824, 2939, 3118, 3129], '(Ac-DLDKKNPEIKIDETGSTC-amide': [2808], '814–830))': [2811], 'QCB,': [2816], 'division': [2818], 'BIOSOURCEInternational': [2820], '(Hopkinton,': [2821], 'MA).': [2822], 'generation': [2827, 3081], 'NP1ECD4': [2830, 3070], 'juxtamembrane': [2836, 3020], 'region': [2837, 3021, 3093], 'therefore': [2844], 'recognize': [2848, 3024, 3058], '(39Rossignol': [2851], 'Gagnon': [2853], 'Genomics.': [2857], '70:': [2859], '211-222Crossref': [2860], '(151)': [2863], 'which': [2866, 3763, 3799], '(40Gagnon': [2874], 'Bielenberg': [2876], 'D.R.': [2877], 'Gechtman': [2878], '97:': [2896], '2573-2578Crossref': [2897], '(253)': [2900], 'Npn-1·VEGFR': [2905], 'complexes': [2906], '(41Fuh': [2907], 'Garcia': [2909], 'K.C.': [2910], 'deVos': [2911], 'A.M.': [2912], '26690-26695Abstract': [2918], '(R2.2)': [2932], 'Ac-SKRKSRPVSVKTFEDIPLEEPC-amide': [2940], '1225–1246),': [2943], 'unique': [2944], 'carboxyl-terminal': [2947], 'VEGFR-2,': [2950, 4439], 'QCB.': [2955], '30': [2959, 3711, 4059], 'kind': [2964], 'gift': [2965], 'David': [2968], 'Ginty': [2969, 2994], '(Johns': [2970], 'Hopkins': [2971], 'This': [2973, 3029, 3063, 3131, 3719, 3779, 4381], '583–856': [2980], 'rat': [2982], '(42Kolodkin': [2984], 'A.L.': [2985], 'Levengood': [2986], 'D.V.': [2987], 'Rowe': [2988], 'E.G.': [2989], 'Tai': [2990], 'Y.T.': [2991], 'Giger': [2992], 'R.J.': [2993], 'D.D.': [2995], '90:': [2998], '753-762Abstract': [2999], '(997)': [3007], 'residues': [3011], 'correspond': [3012], 'MAM': [3015], 'thus': [3023], 'full-length': [3026, 3060], 'protein.': [3028, 3062], 'exclusively': [3033], 'blotting.': [3036], 'C-19': [3038], 'SC-7239)': [3042], 'Santa': [3048], 'Cruz': [3049], 'Biotechnology,': [3050], '(Santa': [3052], 'Cruz,': [3053], 'CA)': [3054], 'sometimes': [3066], 'substituted': [3067], 'immunoprecipitations': [3073], '(as': [3074], 'indicated': [3075], 'figure': [3078], 'legends).': [3079], 'immunogen': [3084], 'antibody,': [3089], 'entire': [3091], 'coding': [3092], '1–760)': [3101], 'expressed': [3103], 'Sf9': [3107], 'Fc': [3111], 'fusion': [3112], '(Regeneron': [3114], 'Pharmaceuticals).': [3115], 'amino-terminal': [3117], 'determined': [3124, 3725, 4213], 'single': [3128], '(ASVGL).': [3130], 'designated': [3134], 'FLK-1(Ig': [3135, 3162], '1–7):Fc.': [3136], 'Unique': [3137], 'clones': [3138], 'tested': [3140], 'blot': [3143, 3909, 3964], 'hybridoma': [3145], 'tissue': [3146, 3177], 'culture': [3147, 3178], 'and/or': [3149], 'antibody.': [3151], '(J5F4A2)': [3156], 'showed': [3157], 'optimal': [3159, 3832], 'reactivity': [3160], '1–7):Fc': [3163], 'cross-react': [3167], '(data': [3170, 3741], 'shown).': [3172, 3743, 3847], 'Antibodies': [3173], 'supernatant': [3179], 'G': [3182], 'column.': [3183], 'Iodination': [3184], 'performed': [3186, 3666, 3691], 'methods': [3191], '43Pajusola': [3224], 'Aprelikova': [3226], 'Pelicci': [3228], 'Weich': [3230], 'Claesson-Welsh': [3232], '9:': [3238], '3545-3555PubMed': [3239], 'Briefly,': [3242], '5': [3243, 4002, 4114], 'carrier-free': [3246], 'suspended': [3251], '90': [3253], 'μl': [3254, 3272, 3292, 3311, 3625], "Dulbecco's": [3256, 3322, 3472, 4086], 'phosphate-buffered': [3257, 3323, 3473], 'saline.': [3258, 3474], 'To': [3259], 'reaction': [3261, 3329], 'tube,': [3262], '1': [3263, 3289, 3392, 3490, 3601, 3998, 4076, 4109], 'mCi': [3264], 'added,': [3268], 'followed': [3269], '40': [3271], 'chloromine': [3274], 'T': [3275], '(1': [3276, 4069], 'μg/μl': [3277, 3297], '0.5': [3279, 4164], 'm': [3280], 'sodium': [3281, 3294, 3299, 3499, 4000], 'phosphate': [3282, 3300], 'buffer,': [3283, 3301], 'pH': [3284, 3302, 3485, 3991, 4188], '7.5),': [3285], 'incubated': [3287, 3371, 3583], 'min.': [3290], '50': [3291, 3405, 3995], 'metabisulfite': [3295], '(2': [3296], '7.5)': [3303], 'added': [3305, 3326, 3703], 'stop': [3307], 'reaction.': [3309], '500': [3310], 'column': [3313, 3335, 3347], 'elution': [3314], 'buffer': [3315, 3382, 3434, 3458, 3481, 3599, 3628, 3987, 4107, 4124], '(0.5%': [3316], 'BSA,': [3317], '0.01%': [3318], 'Tween': [3319, 4037], 'saline)': [3324], 'transferred': [3331, 4018, 4154], 'pre-equilibrated': [3333], 'separation': [3337], 'unreacted': [3339], 'iodine.': [3340], 'corrected': [3345], 'recovery': [3348], 'varied': [3350], '4,000': [3352], '15,000': [3354], 'Ci/mmol.': [3355], '3': [3356], '106cells/100-mm': [3358], 'dish': [3359], '24': [3362, 3559], 'prior': [3364, 3561, 4078], 'experiment.': [3367, 3564], '300–700': [3373], 'pm[125I]VEGF165': [3374, 3701], '4': [3376, 3379, 3461, 3508, 3586, 4145], '(minimum': [3383, 3435], 'essential': [3384, 3436], '25': [3386, 3438], 'mm': [3387, 3421, 3439, 3452, 3483, 3488, 3491, 3989, 3996, 3999, 4003, 4186], 'HEPES,': [3388], '0.2%': [3389], 'BSA)': [3390], 'protease': [3397, 3606, 4009, 4126], 'inhibitors': [3398, 4127], '(10': [3399, 4141], 'leupeptin,': [3401], '10': [3402, 3414, 3417, 3493, 3511], 'antipain,': [3404], 'benzamidine,': [3407, 4004], '100': [3408, 3487], 'soy': [3410], 'bean': [3411], 'trypsin': [3412], 'inhibitor,': [3413], 'bestatin,': [3416], 'pepstatin,': [3419], '0.3': [3420], 'phenylmethylsufonyl': [3422], 'fluoride).': [3423], 'Unbound': [3424, 3608], 'ligand': [3425, 3609, 3648], 'removed': [3427, 3467, 3611], 'washing': [3429, 3469, 3613], 'ice-cold': [3431, 3471, 3615, 3985], 'BSA-free': [3432, 3456, 3616], 'HEPES).': [3440], 'Affinity': [3441], 'labeling': [3442], 'receptors': [3445], 'achieved': [3447], 'cross-linking': [3449], '15': [3451], 'disuccinimidyl': [3453, 3464], 'glutarate': [3454, 3465], '(15': [3459], 'min,': [3460], '°C).': [3462], 'Excess': [3463], 'lysed': [3478, 3622, 4121], 'RIP': [3480, 3627], '(20': [3482, 3988], 'Tris-HCl,': [3484, 3990], '7.4,': [3486], 'NaCl,': [3489], 'EDTA,': [3492], 'mmNaI,': [3494], '0.5%': [3495, 3498, 4005, 4045], 'IGEPAL': [3496, 4006], 'CA-630,': [3497, 4007], 'deoxycholate,': [3500], 'BSA).': [3502], 'Lysate': [3503], 'immunoprecipitated': [3505, 4137], '(R2.2,': [3515], 'NP1ECD4,': [3516], 'C-19),': [3518], '0.1%': [3519, 3630, 4036, 4048], 'SDS,': [3520], 'beads.': [3524], 'samples': [3526, 4135], 'separated': [3528, 4014, 4150], '6%': [3530], 'Novex': [3531], 'SDS-polyacrylimide': [3532], '(PAGE)': [3535], 'gels,': [3536], 'images': [3539], 'analyzed': [3541], 'Storm': [3544], 'system': [3545], '(Molecular': [3546, 4206], 'Dynamics,': [3547], 'Sunnyvale,': [3548], '2': [3550], '105cells/well': [3552], '12-well': [3555], 'plate': [3556], 'Depending': [3565], 'upon': [3566], 'equilibrium': [3568], 'dissociation': [3569], 'constant': [3570], '(K': [3571], 'd': [3572, 3754, 3868], ')': [3573], 'studied,': [3578], '100–400': [3579], 'pm': [3580], '[125I]VEGF165': [3581, 3732], '(4': [3584], 'h,': [3585, 4092], '°C)': [3587], 'increasing': [3592, 3697, 4101], 'concentrations': [3593, 3698, 4102], 'unlabeled': [3595, 3647, 3713], 'inhibitors.': [3607], 'buffer.': [3618], '250': [3624], 'SDS': [3631], 'counted': [3633], 'γ': [3636], 'counter.': [3637], 'Generation': [3638], 'competition': [3640, 3663], 'curves': [3641, 4219], 'IC50': [3643], 'values': [3644, 3755, 4211], '(concentration': [3645, 4390], 'reduces': [3650], 'radioligand': [3651, 3809], 'halfway': [3654, 4397], 'between': [3655, 4398], 'upper': [3657], 'lower': [3659], 'plateaus': [3660], 'curve)': [3664], 'Prism': [3669, 3760], 'software': [3670, 3761], 'package': [3671], '(GraphPad': [3672], 'Software': [3673], 'Inc.,': [3674, 4171], 'San': [3675], 'Diego,': [3676], 'direct': [3680], 'measurement': [3681], 'saturation': [3688], 'analysis': [3689, 3786, 3861, 3910, 3965, 4215], 'above': [3694], 'except': [3695], '0.5–3000': [3700], 'nm': [3712], 'estimate': [3716], 'nonspecific': [3717], 'binding.': [3718], 'concentration': [3720], 'range': [3721], 'had': [3722], 'discriminate': [3727], 'heterogeneous': [3729], 'population': [3730], 'sites': [3734, 3749], 'some': [3736], 'immortalized': [3737], 'lines': [3740], 'maximum': [3745], '(B': [3750], 'max)': [3751], 'theK': [3753], 'package,': [3762], 'performs': [3764], 'statistical': [3766], 'assessment': [3767], 'goodness-of-fit': [3769], 'one-binding': [3772, 3840], 'site': [3773, 3777, 3841], 'versus': [3774], 'two-binding': [3776], 'model.': [3778], 'preferred': [3782], 'over': [3783], 'Scatchard': [3785], 'require': [3791], 'transformation': [3793], 'linearization': [3795], 'data,': [3798], 'distort': [3803], 'experimental': [3805], 'errors': [3806], '(44Motulsky': [3812], 'Ransnas': [3814], 'L.A.': [3815], '1987;': [3818], '1:': [3819], '365-374Crossref': [3820], '(1090)': [3823], 'In': [3826, 4365], 'all': [3827, 3852], 'cases': [3828], 'herein,': [3830], 'fit': [3833], 'model': [3842], '(TableI': [3843], 'points': [3850], 'figures': [3853], 'represent': [3854], 'averages': [3856], 'triplicate': [3858], 'determinations.Table': [3859], 'ISaturation': [3860], 'linesCell': [3866], 'lineTypeReceptorsCloneLogK': [3867], '±': [3869, 3873, 3877, 3879, 3883, 3885, 3889, 3891, 3895, 3913, 3917, 3920, 3924, 3927, 3931, 3939, 3943, 3945, 3949, 4414, 4430], 'S.E.K': [3870], 'dBmax±': [3871], 'S.E.nCOS-1TransientVEGFR-2−9.46': [3872], '0.153.39': [3874], '10−1013,670': [3876], '2,8869VEGFR-2·Npn-1−8.84': [3878], '0.001.43': [3880], '10−09245,700': [3882], '0.0001Npn-1−8.68': [3884], '0.172.09': [3886], '10−09151,950': [3888], '55,9573Mock−8.95': [3890], '0.311.11': [3892], '10−098,038': [3894], '2,0804Balb/c1-aBalb/c': [3896], 'readily': [3899, 3954], 'detectable': [3900, 3955], 'levels': [3901, 3956], 'endogenous': [3903, 3958], 'measured': [3906, 3961], '(Fig.': [3911, 3966], '7B).StableVEGFR-2D7R2−9.53': [3912], '0.082.91': [3914], '10−10100,574': [3916], '26,4275VEGFR-2·Npn-1D7R2·Npn-1': [3918], '(4)−9.48': [3919], '0.333.31': [3921], '10−10228,467': [3923], '150,9953Npn-1Npn-1': [3925], '(2)−9.38': [3926], '0.134.17': [3928], '10−10143,306': [3930], '37,4191-bStatistically': [3932], 'then': [3934, 3970, 4096], 'PGBMGH': [3935, 3971], '(p': [3936, 3972], '=': [3937, 3973, 4412, 4417, 4428, 4433], '0.050).5MockPGBMGH−9.65': [3938], '0.132.22': [3940], '10−1048,825': [3942], '16,1184HUVECNativeVEGFR-2·Npn-1−9.77': [3944], '0.121.69': [3946], '10−1049,450': [3948], '3,60021-a': [3950], '7B).1-b': [3967], 'Statistically': [3968], '0.050).': [3974], 'Open': [3975], 'table': [3976], 'new': [3979], 'tab': [3980], 'Cells': [3981, 4119], 'solubilized': [3983], 'RIPA': [3986, 4123], '7.6,': [3992], '150': [3993], 'mmNaCl,': [3994], 'NaF,': [3997], 'orthovanadate,': [4001], 'inhibitors).': [4010], 'SDS-PAGE': [4016], 'onto': [4019, 4155], 'polyvinylidene': [4020, 4156], 'difluoride': [4021, 4157], 'membranes.': [4022, 4158], 'membranes': [4024, 4160], 'probed': [4026, 4162], '(blocked': [4029, 4043], 'BSA': [4032], 'Tris-buffered': [4034], 'saline,': [4035], '(0.1%': [4039], 'TBST))': [4040], 'Blotto': [4046], 'TBST)': [4049], 'R2.2': [4052, 4139, 4197], '(0.55': [4053, 4198], 'μg/ml)': [4054], 'anti-Npn-1': [4057], '(1:5,000)': [4060], 'detected': [4062, 4179], 'ECL.': [4064, 4181], 'HUVEC': [4065], 'cells/flask)': [4072], 'T-75': [4074], 'flasks': [4075], 'week': [4077], 'stimulation.': [4080], 'rinsed': [4084], 'serum-starved': [4090], '(1–2': [4091], '°C),': [4094], 'stimulated': [4097], 'incubation': [4099], 'min': [4115], '°C.': [4118], 'passed': [4129], '23-gauge': [4132], 'needle.': [4133], '°C,': [4146], 'washed': [4147], 'RIPA,': [4149], 'SDS-PAGE,': [4152], '4G10': [4166], 'anti-phosphotyrosine': [4167], '(Upstate': [4169], 'Biotechnology': [4170], 'Lake': [4172], 'Placid,': [4173], 'NY;': [4174], 'catalog': [4175], '05-321)': [4177], 'Membranes': [4182], 'stripped': [4184], '(200': [4185], 'glycine,': [4187], '2.8)': [4189], 'processed': [4191], 'normalization': [4195], 'μg/ml).': [4199], 'bands': [4201], 'quantitated': [4203], 'ImageQuant': [4205], 'Dynamics),': [4207], 'EC50': [4210, 4389, 4411, 4427], 'dose-response': [4218], 'GraphPad': [4222], 'Prism.': [4223], 'VEGF121have': [4227], 'vitro': [4280], 'native': [4366], 'HUVEC,': [4367], 'manifests': [4371], 'relative': [4378], 'characterized': [4386], 'agonist': [4392], 'provokes': [4394], 'base-line': [4400], 'maximal': [4402], 'responses)': [4403], '7.76': [4407], '10−11m': [4409], '(log': [4410, 4426], '−10.11': [4413], '0.113,': [4415], 'n': [4416, 4432], '14)': [4418, 4434], '2.45': [4423], '10−9m': [4425], '−8.61': [4429], '0.091,': [4431], 'stimulating': [4436], 'representative': [4442], 'experiment': [4443], 'illustrated': [4444], 'Fig.': [4446], '1.': [4447], 'reported': [4449], 'similarity': [4450]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2135743455', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 13}, {'year': 2018, 'cited_by_count': 11}, {'year': 2017, 'cited_by_count': 9}, {'year': 2016, 'cited_by_count': 6}, {'year': 2015, 'cited_by_count': 13}, {'year': 2014, 'cited_by_count': 12}, {'year': 2013, 'cited_by_count': 15}, {'year': 2012, 'cited_by_count': 7}], 'updated_date': '2024-12-13T00:23:07.017018', 'created_date': '2016-06-24'}
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