Publication Information

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'https://openalex.org/W2089032508', 'https://openalex.org/W2097634036', 'https://openalex.org/W2110356212', 'https://openalex.org/W2115338196', 'https://openalex.org/W2124122523', 'https://openalex.org/W2124433916', 'https://openalex.org/W2125378729', 'https://openalex.org/W2126121201', 'https://openalex.org/W2155383113', 'https://openalex.org/W2169052484', 'https://openalex.org/W2415186660', 'https://openalex.org/W4319704909', 'https://openalex.org/W68369576'], 'related_works': ['https://openalex.org/W4391375266', 'https://openalex.org/W2748952813', 'https://openalex.org/W2411581817', 'https://openalex.org/W2315681052', 'https://openalex.org/W2088950084', 'https://openalex.org/W2044264814', 'https://openalex.org/W2035906232', 'https://openalex.org/W2035435589', 'https://openalex.org/W2015076784', 'https://openalex.org/W1966687443'], 'abstract_inverted_index': {'Transcription': [0, 288], 'factor': [1, 3, 289, 291, 702, 748, 955, 957], 'NF-E2-related': [2, 290, 701, 747, 956], '2': [4, 292, 958, 3679], '(Nrf2)': [5, 293, 959], 'regulates': [6, 294], 'the': [7, 24, 35, 55, 71, 82, 108, 122, 125, 143, 148, 175, 182, 209, 214, 218, 252, 273, 282, 295, 312, 323, 343, 359, 370, 396, 410, 413, 431, 436, 463, 470, 497, 502, 506, 540, 561, 570, 608, 965, 1116, 1162, 1165, 1189, 1198, 1303, 1316, 1319, 1330, 1366, 1393, 1399, 1450, 1453, 1466, 1491, 1503, 1513, 1535, 1622, 1627, 1632, 1654, 1717, 1723, 1768, 1773, 1788, 1803, 1923, 1968, 1976, 1981, 2004, 2095, 2313, 2322, 2387, 2564, 2575, 2583, 2606, 2609, 2636, 2702, 2719, 2730, 2748, 2755, 2761, 2767, 2862, 2869, 2880, 2922, 2926, 2940, 2978, 2993, 3074, 3381, 3396, 3402, 3410, 3419, 3426, 3438, 3492, 3496, 3573, 3626, 3693, 3779, 3801, 3808, 3810, 3875, 3897, 3919, 3923, 3954, 3970, 3975, 3991, 3998, 4002, 4055, 4061, 4066, 4071, 4098, 4111, 4125, 4137, 4145, 4148, 4154, 4176, 4191, 4203, 4211, 4222, 4230, 4245, 4252, 4299], 'induction': [8, 178, 296, 466], 'of': [9, 27, 68, 75, 97, 111, 124, 163, 177, 212, 230, 254, 272, 281, 285, 297, 315, 356, 363, 385, 399, 412, 451, 465, 500, 518, 542, 560, 569, 573, 582, 970, 1120, 1164, 1167, 1191, 1318, 1334, 1375, 1452, 1455, 1493, 1614, 1629, 1656, 1725, 1770, 1777, 1791, 1918, 1925, 2072, 2125, 2317, 2328, 2375, 2567, 2585, 2596, 2608, 2616, 2624, 2635, 2711, 2721, 2729, 2758, 2770, 2804, 2854, 2861, 2883, 2925, 2936, 2983, 3001, 3022, 3076, 3097, 3116, 3454, 3472, 3513, 3528, 3687, 3699, 3890, 3914, 3922, 3926, 3935, 3967, 4001, 4017, 4039, 4042, 4068, 4073, 4086, 4090, 4101, 4136, 4164, 4180, 4194, 4214, 4233, 4261, 4304], 'Phase': [10, 298, 1457], 'II': [11, 299, 613, 1458], 'detoxifying': [12, 300, 609, 1170, 2481], 'enzymes': [13, 301, 606, 878, 975, 1173, 1193, 1461], 'as': [14, 16, 101, 263, 302, 304, 389, 551, 618, 685, 1643, 1809, 2064, 2392, 2752, 2754, 3131, 3395, 3870, 3886, 3988, 4013, 4045, 4182], 'well': [15, 303, 2753, 3533], 'anti-oxidative': [17, 305], 'enzymes.': [18, 306], 'In': [19, 307, 576, 2558, 2734, 3498, 3579, 3996, 4050], 'this': [20, 223, 308, 511, 2559, 2735, 3310, 4023], 'study,': [21, 309, 2560, 2736], 'we': [22, 310, 2561, 2737], 'investigated': [23, 311], 'transactivation': [25, 30, 57, 62, 66, 73, 94, 109, 131, 145, 172, 194, 210, 232, 236, 256, 275, 313, 318, 345, 350, 354, 361, 382, 397, 419, 433, 460, 482, 498, 520, 524, 544, 563, 1478, 1495, 1789, 1907, 2097, 2569, 2591, 2600, 2698, 2707, 2723, 2732, 2768, 2864, 3949, 3977, 3999, 4033, 4099, 4131, 4171, 4212, 4231], 'potential': [26, 159, 237, 314, 447, 525], 'different': [28, 228, 235, 239, 316, 516, 523, 527, 2078, 2468, 2565, 2586, 3924], 'Nrf2': [29, 83, 130, 193, 231, 245, 255, 274, 317, 371, 418, 481, 519, 533, 543, 562, 1113, 1199, 1312, 1335, 1361, 1387, 1477, 1494, 1533, 1630, 1684, 1726, 1771, 1792, 1906, 1970, 2020, 2096, 2388, 2568, 2590, 2599, 2697, 2722, 2731, 2771, 2863, 2870, 3927, 4062, 4123, 4305], 'domain': [31, 58, 132, 195, 233, 257, 319, 346, 420, 483, 521, 545, 1333, 2098, 2316, 2592, 2699, 2865, 3978, 4157], 'regions': [32, 320, 2566], 'by': [33, 179, 200, 259, 269, 279, 321, 467, 488, 547, 557, 567, 1321, 1469, 1638, 1797, 1802, 1909, 2157, 2321, 2605, 2773, 2875, 2931, 2953, 3057, 3295, 3445, 3495, 3539, 3618, 3622, 3692, 3896], 'using': [34, 322, 2879, 3380, 3487, 3540, 3703, 3714, 3800], 'Gal4-Nrf2': [36, 324, 2855, 3916, 3936, 4056], 'chimeras': [37, 325, 2860, 4004], 'and': [38, 70, 78, 105, 113, 138, 196, 217, 238, 326, 358, 366, 393, 401, 426, 484, 505, 526, 681, 782, 967, 980, 1123, 1171, 1197, 1209, 1396, 1523, 1687, 1775, 1921, 2009, 2019, 2084, 2580, 2631, 2692, 2780, 2791, 2819, 2841, 2857, 2888, 2894, 2900, 2906, 2918, 2985, 2987, 2995, 3050, 3081, 3092, 3119, 3125, 3458, 3525, 3553, 3589, 3696, 3708, 3741, 3817, 3842, 4007, 4075, 4092, 4129, 4295], 'Gal4-Luc': [39, 327, 2576, 3955], 'reporter': [40, 328, 2479, 2947, 3593, 3956], 'co-transfection': [41, 329, 2577, 3957], 'assay': [42, 330, 2578, 3958], 'system': [43, 331, 3718, 3803, 3959], 'in': [44, 91, 115, 332, 379, 403, 964, 976, 1161, 1182, 1187, 1307, 1315, 1365, 1609, 1621, 1623, 1653, 1729, 1767, 1772, 1967, 2076, 2311, 2574, 2619, 2642, 2793, 2992, 3309, 3466, 3522, 3531, 3556, 3591, 3625, 3639, 3728, 3762, 3767, 3819, 3858, 3877, 3943, 3953, 3960, 4022, 4047, 4063, 4124, 4144, 4159], 'HepG2': [45, 333, 2620, 2783, 3961, 4064, 4127], 'cells.': [46, 334, 2621, 3962], 'The': [47, 64, 335, 352, 1497, 2052, 2594, 2622, 2709, 2909, 2945, 2999, 3020, 3391, 3398, 3412, 3441, 3613, 3684, 3720, 3750, 3796, 3853, 4079], 'results': [48, 336, 2687, 4080, 4239], 'indicated': [49, 337, 2088], 'that': [50, 81, 135, 227, 251, 338, 369, 423, 515, 539, 876, 953, 1327, 1502, 1722, 1787, 1992, 2089, 2152, 2364, 2384, 2472, 2690, 2739, 3863, 4016, 4026, 4038, 4084, 4117, 4241, 4293], 'chimera': [51, 76, 215, 339, 364, 503, 3971, 4029, 4057, 4102, 4118], 'Gal4-Nrf2-(1–370),': [52, 340], 'which': [53, 189, 341, 477, 1188, 1470, 2938, 3939, 3984, 4186], 'contains': [54, 342, 2939], 'full': [56, 344], 'showed': [59, 165, 203, 347, 453, 491, 3979, 4083], 'very': [60, 348, 3980], 'potent': [61, 349], 'activity.': [63, 95, 247, 351, 383, 535, 1496, 1780, 2593, 2708, 4172], 'high': [65, 353, 3981], 'activity': [67, 133, 146, 173, 258, 284, 355, 421, 434, 461, 546, 572, 1479, 1790, 1908, 2331, 2724, 2751, 2769, 3568, 3605, 3615, 3620, 3872, 4034, 4072, 4100, 4132, 4179, 4213, 4232], 'Gal4-Nrf2-(113–251)': [69, 114, 164, 357, 402, 452, 2743, 3393, 4030], 'diminished': [72, 360, 4012], 'activities': [74, 110, 211, 362, 398, 499, 2573, 3950, 4000], 'Gal4-Nrf2-(1–126)': [77, 365, 4005], 'Gal4-Nrf2-(230–370)': [79, 367, 4008], 'suggested': [80, 250, 368, 538, 4240], 'N-terminal': [84, 372, 714, 760, 1331, 3075, 3928, 4300], '113–251': [85, 373], 'amino': [86, 374, 2814, 2873, 3930], 'acids': [87, 375, 3931, 4302], 'region': [88, 376], 'is': [89, 377, 1313, 1501, 1605, 1721, 1786, 2361, 2629, 2633, 3018, 3038, 3417, 3424, 3431], 'critical': [90, 378, 962], 'maintaining': [92, 380], 'its': [93, 170, 381, 458, 1520, 1737, 1912, 1916, 1926, 2329, 2706, 4130, 4160, 4170], 'Overexpression': [96, 384], 'upstream': [98, 260, 386, 548], 'MAPKs': [99, 240, 261, 387, 528, 549, 1810, 2597, 2618, 2712], 'such': [100, 262, 388, 550, 617, 684, 1642, 1808, 2391], 'Raf,': [102, 390], 'MEKK1,': [103, 391], 'TAK1-ΔN,': [104, 392], 'ASK1': [106, 394], 'up-regulated': [107, 395], 'Gal4-Nrf2-(1–370)': [112, 144, 216, 400, 432, 504, 3972], 'a': [116, 152, 404, 440, 580, 883, 961, 1125, 1299, 1322, 1528, 2061, 2065, 2069, 3053, 3107, 3470, 3598, 3607, 3715, 3859, 3933, 3964], 'dose-dependent': [117, 405], 'manner.': [118, 406], 'Further': [119, 407], 'investigation': [120, 408], 'on': [121, 129, 158, 169, 208, 244, 409, 417, 446, 457, 496, 532, 1519, 1901, 1980, 2589, 2598, 2742, 2747, 4070, 4110, 4169, 4197, 4229, 4249], 'effects': [123, 243, 411, 531, 2584, 2595, 4067, 4168, 4248], 'three': [126, 414, 1486, 3775], 'MAPK': [127, 160, 415, 448, 2158, 2323, 2365, 2473, 2587], 'pathways': [128, 141, 416, 429, 1475, 2079, 2475, 2694], 'demonstrated': [134, 226, 422, 514, 952, 2688, 4116, 4292], 'both': [136, 213, 424, 501], 'ERK': [137, 201, 425, 489, 2691], 'JNK': [139, 427, 2693], 'signaling': [140, 428, 1474, 2474], 'stimulated': [142, 430], 'while': [147, 435, 2701, 4104, 4221], 'p38': [149, 437, 2703], 'pathway': [150, 438, 2704], 'played': [151, 439], 'negative': [153, 441], 'role.': [154, 442], 'Site-directed': [155, 443, 3374], 'mutagenesis': [156, 444, 2741, 3384], 'studies': [157, 445, 873, 950, 2087, 2466], 'phosphorylation': [161, 271, 449, 559, 2728], 'sites': [162, 450, 2924], 'no': [166, 454, 4105, 4167, 4227], 'significant': [167, 455, 4106], 'effect': [168, 456, 2746, 2757, 4193, 4228], 'basal': [171, 459, 1373, 2749], 'or': [174, 462, 584, 600, 891, 1176, 1384, 1459, 1612, 1616, 1648, 1874, 1903, 2121, 2382, 2422, 2480, 3621], 'fold': [176, 464, 3871], 'Raf.': [180, 468], 'Interestingly,': [181, 469], 'nuclear': [183, 471, 1913, 2066], 'transcription': [184, 472, 954, 1121, 1374, 1779, 1924, 1997, 2073, 2371, 2389, 2750], 'coactivator': [185, 286, 473, 574, 2067, 2775], 'CREB-binding': [186, 474, 721, 767, 2053], 'protein': [187, 475, 698, 727, 744, 773, 1324, 1506, 1645, 1649, 1738, 2007, 2054, 2127, 2427, 3068, 3623, 3685, 3700, 3797], '(CBP),': [188, 476], 'can': [190, 197, 478, 485, 1634, 1793, 1973, 1986, 1993, 2091, 2154, 2476, 4095], 'bind': [191, 479, 1974, 1987, 2092, 2385], 'to': [192, 480, 578, 595, 978, 1115, 1206, 1309, 1382, 1389, 1510, 1731, 1920, 1975, 1988, 2014, 2059, 2094, 2326, 2386, 2644, 2716, 2976, 3073, 3505, 3536, 3572, 3710, 3862, 3874, 4052, 4060, 4122, 4139, 4190, 4216], 'be': [198, 267, 486, 555, 1390, 1508, 1619, 1636, 1795, 2155, 4188], 'activated': [199, 487, 1801, 2696, 3127], 'cascade,': [202, 490], 'synergistic': [204, 492], 'stimulation': [205, 493], 'with': [206, 494, 1329, 1998, 2017, 2797, 3048, 3484, 3547, 3585, 3606, 3724, 3755, 3777, 3783, 3814, 3840, 3845, 3905, 3990, 4015, 4141, 4184, 4202], 'Raf': [207, 264, 495, 552], 'full-length': [219, 507, 3976], 'Nrf2.': [220, 508, 1999], 'Taken': [221, 509], 'together,': [222, 510], 'study': [224, 512, 3311], 'clearly': [225, 513], 'segments': [229, 517], 'have': [234, 241, 522, 529, 589, 874, 951, 2011, 2150, 2470, 3312], 'differential': [242, 530], 'transcriptional': [246, 283, 534, 571, 2330], 'It': [248, 536, 2360], 'also': [249, 537, 1363, 1635, 1794, 1985, 2603, 2713, 2950, 4174], 'up-regulation': [253, 541, 2720], 'may': [265, 553, 1362, 1526, 1734], 'not': [266, 554, 1971, 4236, 4264], 'mediated': [268, 556, 2772], 'direct': [270, 558, 2727], 'domain,': [276, 564, 2570], 'but': [277, 565, 1984], 'rather': [278, 566], 'regulation': [280, 568, 1163, 1454, 1492, 2607, 2623], 'CBP.': [287, 575, 2776], 'order': [577, 4051], 'survive': [579], 'variety': [581, 2071], 'environmental': [583], 'intracellular': [585], 'stress,': [586, 1311, 1386], 'mammalian': [587, 1169], 'cells': [588, 1320, 1379, 1774, 2784, 3463, 3481, 3581, 3631, 3879, 4128], 'developed': [590], 'robust': [591], 'cellular': [592], 'defensive': [593, 605, 974], 'systems': [594], 'protect': [596], 'themselves': [597], 'from': [598, 1392, 1534, 1631, 1727, 2467, 2787, 2832, 2846, 2868, 2965, 3088, 3109, 3386], 'oxidative': [599, 979, 1175, 1310, 1383, 1514, 1804, 2645], 'electrophilic': [601, 1177, 1385], 'stress.': [602, 1805], 'Among': [603, 2000], 'these': [604, 877, 973, 1192, 1471, 1524, 1608, 1657, 2001], 'are': [607, 879, 1194, 1202, 1380, 1480, 1488, 3868, 3884, 3940], 'systems,': [610], 'including': [611, 2080], 'phase': [612], 'drug': [614], 'metabolizing': [615], 'enzymes,': [616, 683], 'glutathione': [619], 'S-transferase,': [620], 'NADP(H):quinone': [621], 'oxidoreductase,': [622], 'UDP-glucuronosyltransferase': [623], '(1Zhang': [624], 'Y.': [625, 917, 994, 1006, 1049, 1341, 1427, 1563, 1857, 2100, 2231, 3136, 3154, 3227, 3257, 4270], 'Talalay': [626, 804, 1566], 'P.': [627, 805, 1134, 1567, 2192, 2430, 2665, 3233], 'Cho': [628], 'C.G.': [629], 'Posner': [630], 'G.H.': [631], 'Proc.': [632, 666, 1023, 1143, 1215, 1407, 1568, 1666, 1935, 3193], 'Natl.': [633, 667, 1024, 1144, 1216, 1408, 1569, 1667, 1936, 3194], 'Acad.': [634, 668, 1025, 1145, 1217, 1409, 1570, 1668, 1937, 3195], 'Sci.': [635, 669, 1026, 1146, 1218, 1262, 1410, 1571, 1669, 1842, 1938, 3196], 'U.': [636, 670, 1027, 1147, 1219, 1411, 1572, 1670, 1939, 3197], 'S.': [637, 671, 829, 988, 1028, 1043, 1051, 1148, 1220, 1412, 1540, 1573, 1671, 1940, 2182, 2186, 2436, 2493, 3164, 3198, 3209, 3225, 3235, 3349], 'A.': [638, 672, 1029, 1140, 1149, 1221, 1246, 1413, 1574, 1672, 1941, 2108, 2190, 2196, 2261, 2339, 3192, 3199, 4278], '1992;': [639, 923], '89:': [640], '2399-2403Crossref': [641], 'PubMed': [642, 655, 676, 797, 819, 845, 867, 913, 929, 945, 1014, 1033, 1065, 1085, 1153, 1225, 1240, 1266, 1293, 1355, 1417, 1439, 1547, 1578, 1598, 1676, 1711, 1761, 1832, 1846, 1869, 1893, 1945, 1961, 2047, 2116, 2142, 2176, 2206, 2221, 2249, 2277, 2305, 2355, 2417, 2460, 2509, 2539, 2553, 2655, 2681, 3148, 3178, 3203, 3219, 3251, 3286, 3341, 3369, 4286], 'Scopus': [643, 656, 677, 798, 846, 868, 1015, 1034, 1066, 1154, 1226, 1241, 1267, 1294, 1356, 1418, 1440, 1548, 1579, 1599, 1677, 1712, 1762, 1833, 1847, 1870, 1894, 1946, 1962, 2048, 2117, 2143, 2177, 2207, 2222, 2250, 2278, 2306, 2356, 2418, 2461, 2510, 2540, 2554, 2656, 2682, 3149, 3179, 3204, 3220, 3252, 3287, 3342, 3370, 4287], '(1507)': [644], 'Google': [645, 658, 679, 800, 820, 848, 870, 914, 930, 946, 1017, 1036, 1068, 1086, 1111, 1156, 1228, 1243, 1269, 1296, 1358, 1420, 1442, 1550, 1581, 1601, 1679, 1714, 1764, 1835, 1849, 1872, 1896, 1948, 1964, 2050, 2119, 2145, 2179, 2209, 2224, 2252, 2280, 2308, 2358, 2420, 2463, 2512, 2542, 2556, 2658, 2684, 3151, 3181, 3206, 3222, 3254, 3289, 3344, 3372, 4289], 'Scholar,': [646, 659, 801, 821, 849, 915, 931, 1018, 1037, 1069, 1087, 1229, 1244, 1270, 1421, 1551, 1582, 1836, 1949, 2180, 2210, 2225, 2253, 2281, 2513, 2543, 2659, 3152, 3182, 3207, 3223, 3255, 3345], '2Morse': [647], 'M.A.': [648, 3186], 'Stoner': [649], 'G.D.': [650], 'Carcinogenesis.': [651], '1993;': [652], '14:': [653, 2045], '1737-1746Crossref': [654], '(407)': [657], '3Chan': [660], 'K.': [661, 984, 992, 1000, 1020, 1041, 1073, 1091, 1136, 1212, 1248, 1337, 1345, 1423, 1431, 1433, 1559, 1695, 1853, 1861, 1863, 2028, 2030, 2034, 2102, 2440, 4272], 'Han': [662, 3139, 3165, 3240, 3273], 'X.D.': [663], 'Kan': [664, 1021, 1141, 1213], 'Y.W.': [665, 1022, 1142, 1214], '2001;': [673, 1082, 1108, 1263, 2113, 2139, 2241, 4283], '98:': [674], '4611-4616Crossref': [675], '(643)': [678], 'Scholar),': [680, 1443, 1715, 1765, 1850, 1873, 2421], 'anti-oxidant': [682, 705, 751, 887, 1172, 1460, 2640], 'heme': [686, 694, 740], 'oxygenase-1': [687], '(HO-1)': [688], '1The': [689], 'abbreviations': [690, 736], 'used': [691, 737, 3308, 3408], 'are:': [692, 738], 'HO-1,': [693, 739], 'oxygenase-1;': [695, 741], 'MAPK,': [696, 742], 'mitogen-activated': [697, 743, 1644], 'kinase;': [699, 711, 715, 745, 757, 761], 'Nrf2,': [700, 746], '2;': [703, 749], 'ARE,': [704, 750], 'responsive': [706, 752, 888], 'element;': [707, 753], 'ERK,': [708, 754], 'extracellular': [709, 755], 'signal-regulated': [710, 756], 'JNK,': [712, 758], 'c-Jun': [713, 759], 'CREB,': [716, 762, 2081], 'cAMP': [717, 763], 'responsive-binding': [718, 764], 'protein;': [719, 722, 765, 768], 'CBP,': [720, 766], 'PI3K,': [723, 769], 'phosphatidylinositol': [724, 770], '3-kinase;': [725, 771], 'PKC,': [726, 772], 'kinase': [728, 774, 1640, 1650, 1799], 'C;': [729, 775], 'SFN,': [730, 776], 'sulforaphane;': [731, 777], 'EpRE,': [732, 778], 'electrophile': [733, 779, 892, 4204], 'response': [734, 780, 893, 977, 1308, 1730, 2643], 'element.1The': [735], 'element.': [781], 'γ-glutamylcysteine': [783], 'synthetase': [784], '(γGCS)': [785], '(4Primiano': [786], 'T.': [787, 803, 986, 990, 996, 1039, 1047, 1254, 1256, 1258, 1343, 1404, 1429, 1663, 1741, 1812, 1859, 1879, 1932, 2022], 'Sutter': [788, 1076], 'T.R.': [789, 1077], 'Kensler': [790, 1078], 'T.W.': [791, 1079], 'Adv.': [792], 'Pharmacol.': [793, 2549], '1997;': [794, 1011, 2044, 3243, 3278], '38:': [795], '293-328Crossref': [796], '(99)': [799], '5Prestera': [802], 'Alam': [806, 2672], 'J.': [807, 823, 834, 856, 904, 920, 936, 1054, 1252, 1587, 1700, 1750, 1821, 1882, 2024, 2026, 2032, 2165, 2238, 2263, 2266, 2287, 2293, 2294, 2341, 2344, 2399, 2405, 2406, 2449, 2487, 2498, 2528, 2651, 2673, 2677, 3140, 3166, 3167, 3241, 3265, 3274, 3275, 3330, 3358], 'Ahn': [808], 'Y.I.': [809], 'Lee': [810], 'P.J.': [811, 1743, 1814], 'Choi': [812, 830, 2494], 'A.M.': [813, 831, 2495], 'Mol.': [814, 1080], 'Med.': [815, 1081], '1995;': [816], '1:': [817], '827-837Crossref': [818], '6Alam': [822], 'Stewart': [824, 2488], 'D.': [825, 1538, 2184, 2198, 2229, 2259, 2265, 2337, 2343, 2489], 'Touchard': [826, 2490], 'C.': [827, 1103, 1280, 2438, 2491, 2517, 3156, 3184, 3319], 'Boinapally': [828, 2492], 'Cook': [832, 2496], 'J.L.': [833, 2497], 'Biol.': [835, 857, 905, 921, 937, 1055, 1588, 1701, 1751, 1822, 1883, 2166, 2239, 2267, 2295, 2345, 2407, 2450, 2499, 2529, 3168, 3276, 3331, 3359], 'Chem.': [836, 858, 906, 922, 938, 1056, 1589, 1702, 1752, 1823, 1884, 2167, 2240, 2268, 2296, 2346, 2408, 2451, 2500, 2530, 3169, 3277, 3332, 3360], '1999;': [837, 859, 1030, 1222, 1352, 2203, 2218, 2501], '274:': [838, 860, 2502], '26071-26078Abstract': [839, 2503], 'Full': [840, 842, 862, 864, 910, 926, 942, 1060, 1062, 1593, 1595, 1706, 1708, 1756, 1758, 1827, 1829, 1888, 1890, 2171, 2173, 2244, 2246, 2272, 2274, 2300, 2302, 2350, 2352, 2412, 2414, 2455, 2457, 2504, 2506, 2534, 2536, 3173, 3175, 3246, 3248, 3281, 3283, 3336, 3338, 3364, 3366], 'Text': [841, 843, 863, 865, 911, 927, 943, 1061, 1063, 1594, 1596, 1707, 1709, 1757, 1759, 1828, 1830, 1889, 1891, 2172, 2174, 2245, 2247, 2273, 2275, 2301, 2303, 2351, 2353, 2413, 2415, 2456, 2458, 2505, 2507, 2535, 2537, 3174, 3176, 3247, 3249, 3282, 3284, 3337, 3339, 3365, 3367], 'PDF': [844, 866, 912, 928, 944, 1064, 1597, 1710, 1760, 1831, 1892, 2175, 2248, 2276, 2304, 2354, 2416, 2459, 2508, 2538, 3177, 3250, 3285, 3340, 3368], '(1057)': [847, 2511], '7Wild': [850], 'A.C.': [851], 'Moinova': [852], 'H.R.': [853], 'Mulcahy': [854, 1585, 1839, 1952], 'R.T.': [855, 1586, 1840, 1953], '33627-33636Abstract': [861], '(513)': [869], 'Scholar).': [871, 947, 1112, 1157, 1297, 1359, 1602, 1680, 1965, 2051, 2146, 2359, 2464, 2557, 2685, 3290, 3373], 'Previous': [872, 2465], 'shown': [875, 2058, 2151, 2471, 3942, 4046], 'coordinately': [880, 1994], 'regulated': [881, 1796], 'through': [882, 1690, 2122, 2372, 2726], 'consensus': [884], 'cis-element': [885], 'called': [886, 1325], 'element': [889, 894], '(ARE)': [890], '(EpRE)': [895], 'at': [896, 1484, 3448, 3469, 3744, 3769, 3790, 3834, 3850, 3881, 4088, 4207, 4258], 'their': [897, 2572], '5′-flanking': [898], 'promoters': [899], '(8Rushmore': [900], 'T.H.': [901, 2525, 3327, 3355], 'Pickett': [902, 934, 1405, 1664, 1748, 1819, 1880, 1933], 'C.B.': [903, 935, 1406, 1665, 1749, 1820, 1881, 1934], '1990;': [907], '265:': [908], '14648-14653Abstract': [909], '9Li': [916], 'Jaiswal': [918, 1541], 'A.K.': [919, 1542], '267:': [924], '15097-15104Abstract': [925], '10Favreau': [932], 'L.V.': [933], '1991;': [939], '266:': [940], '4556-4561Abstract': [941], 'Recent': [948, 2086], 'extensive': [949], 'plays': [960], 'role': [963, 1160, 2063], 'constitutive': [966], 'inducible': [968], 'expression': [969, 1166, 1190, 1306, 2612, 2628, 3485], 'genes': [971, 1928, 2482, 2641], 'encoding': [972], 'xenobiotic': [981], 'stress': [982, 1178, 1515, 1733, 2646], '(11Itoh': [983], 'Chiba': [985], 'Takahashi': [987, 1042], 'Ishii': [989, 1342], 'Igarashi': [991, 1344, 2033], 'Katoh': [993, 1048, 1340, 1562, 4266], 'Oyake': [995], 'Hayashi': [997], 'N.': [998, 1339, 1561, 2036, 2283, 2395], 'Satoh': [999], 'Hatayama': [1001], 'I.': [1002, 1138, 2289, 2401], 'Yamamoto': [1003, 1052, 1074, 1092, 1259, 1285, 1348, 1564, 1696, 2039, 2109, 4279], 'M.': [1004, 1053, 1075, 1089, 1093, 1233, 1260, 1278, 1286, 1349, 1565, 1693, 1697, 2038, 2040, 2106, 2110, 2132, 2663, 3211, 3213, 3261, 4276, 4280], 'Nabeshima': [1005], 'Biochem.': [1007, 1287, 1954, 2135, 2199, 2548, 2676, 3141], 'Biophys.': [1008, 1235, 1955, 2136, 2200, 3142], 'Res.': [1009, 1107, 1956, 2137, 2201, 3143], 'Commun.': [1010, 1957, 2138, 2202, 3144], '236:': [1012], '313-322Crossref': [1013], '(3146)': [1016], '12Chan': [1019], '96:': [1031, 1223], '12731-12736Crossref': [1032, 1224], '(522)': [1035, 1227], '13Ishii': [1038], 'Itoh': [1040, 1072, 1090, 1247, 1558, 1694, 2023, 2101, 4271], 'Sato': [1044], 'H.': [1045, 1425, 1855, 2233, 3259, 3297], 'Yanagawa': [1046], 'Bannai': [1050], '2000;': [1057, 1237, 1290, 1414, 1673, 1942, 1958, 2531, 3333, 3361], '275:': [1058, 2532, 3334, 3362], '16023-16029Abstract': [1059], '(1225)': [1067], '14Kwak': [1070], 'M.K.': [1071], '7:': [1083], '135-145Crossref': [1084], '15McMahon': [1088], 'Chanas': [1094, 1273], 'S.A.': [1095, 1274], 'Henderson': [1096, 1275], 'C.J.': [1097, 1276, 2669], 'McLellan': [1098], 'L.I.': [1099], 'Wolf': [1100, 1283], 'C.R.': [1101, 1284], 'Cavin': [1102], 'Hayes': [1104, 1698], 'J.D.': [1105, 1272, 1347, 1699], 'Cancer': [1106], '61:': [1109], '3299-3307PubMed': [1110], 'belongs': [1114], 'CNC': [1117], '(Cap-N-Collar)': [1118], 'family': [1119, 2128], 'factors': [1122, 1991, 2074, 2381], 'possesses': [1124], 'highly': [1126, 2362], 'conserved': [1127], 'basic': [1128], 'region-leucine': [1129], 'zipper': [1130], '(bZip)': [1131], 'structure': [1132], '(16Moi': [1133], 'Chan': [1135], 'Asunis': [1137], 'Cao': [1139], '1994;': [1150], '91:': [1151], '9926-9930Crossref': [1152], '(1205)': [1155], 'Its': [1158], 'important': [1159], 'many': [1168], 'under': [1174, 1368], 'has': [1179, 1462, 2056], 'been': [1180, 1463, 2012, 2057, 3313], 'verified': [1181, 2604, 3444], 'various': [1183, 2077], 'Nrf2-deficient': [1184], 'mice': [1185, 1201], 'experiments,': [1186], 'dramatically': [1195, 1735, 4011], 'abolished': [1196], 'knockout': [1200], 'much': [1203, 4177], 'more': [1204], 'susceptible': [1205], 'carcinogen-induced': [1207], 'toxicity': [1208], 'carcinogenesis': [1210], '(12Chan': [1211], '17Chan': [1230], 'J.Y.': [1231], 'Kwong': [1232], 'Biochim.': [1234], 'Acta.': [1236], '1517:': [1238], '19-26Crossref': [1239], '(261)': [1242], '18Enomoto': [1245], 'Nagayoshi': [1249], 'E.': [1250, 2042, 2104, 2661, 2667, 3231, 4274], 'Haruta': [1251], 'Kimura': [1253], "O'Connor": [1255], 'Harada': [1257], 'Toxicol.': [1261, 1841], '59:': [1264], '169-177Crossref': [1265], '(629)': [1268], '19Hayes': [1271], 'McMahon': [1277], 'Sun': [1279], 'Moffat': [1281], 'G.J.': [1282], 'Soc.': [1288], 'Trans.': [1289], '28:': [1291], '33-41Crossref': [1292], '(285)': [1295], 'As': [1298, 4199], 'sensor': [1300], 'for': [1301, 1372, 1490, 2068, 3409, 3415, 3422, 3429, 3518, 3550, 3560, 3603, 3747, 3793, 3831, 3865, 3902], 'regulating': [1302], 'ARE-mediated': [1304], 'gene': [1305, 1447, 1996, 2370, 2627], 'sequestered': [1314], 'cytoplasm': [1317], 'cytoskeleton-related': [1323], 'Keap1': [1326, 1505, 1728, 2959, 2984, 4069, 4087, 4140, 4155, 4165, 4196, 4246], 'interacts': [1328], 'Neh2': [1332], '(20Itoh': [1336], 'Wakabayashi': [1338, 1560], 'Engel': [1346], 'Genes': [1350, 2111, 4281], 'Dev.': [1351], '13:': [1353], '76-86Crossref': [1354], '(2738)': [1357], 'But': [1360], 'exist': [1364], 'nucleus': [1367, 1400], 'homeostatic': [1369], 'resting': [1370], 'conditions': [1371, 1611], 'Nrf2-mediated': [1376, 2369], 'genes.': [1377], 'When': [1378], 'exposed': [1381], 'appears': [1388], 'liberated': [1391], 'Keap1-Nrf2': [1394], 'complex': [1395, 1536, 1633], 'translocates': [1397], 'into': [1398, 2914, 2921, 3052], '(21Huang': [1401, 1660, 1929], 'H.C.': [1402, 1661, 1745, 1816, 1877, 1930], 'Nguyen': [1403, 1662, 1878, 1931], '97:': [1415, 1674, 1943], '12475-12480Crossref': [1416, 1675, 1944], '(434)': [1419, 1678, 1947], '22Nakaso': [1422], 'Yano': [1424, 1854], 'Fukuhara': [1426, 1856], 'Takeshima': [1428, 1858], 'Wada-Isoe': [1430, 1860], 'Nakashima': [1432, 1862], 'FEBS': [1434, 1864, 3214], 'Lett.': [1435, 1865, 3215], '2003;': [1436, 1703, 1753, 1824, 1843, 1866, 2297, 2409, 2678], '546:': [1437, 1867], '181-184Crossref': [1438, 1868], '(276)': [1441, 1871], 'thereby': [1444, 1531], 'activating': [1445, 1922], 'Nrf2-dependent': [1446, 1456, 1778, 2484], 'transcription.': [1448], 'Although': [1449], 'understanding': [1451], 'greatly': [1464], 'enhanced,': [1465], 'exact': [1467], 'mechanisms': [1468, 1487, 2485], 'oxidative/electrophile': [1472], 'stress-triggered': [1473], 'regulate': [1476, 1905, 1995, 2368, 2477], 'still': [1481], 'unclear.': [1482], 'Currently,': [1483], 'least': [1485], 'proposed': [1489, 1500, 1720, 1785], 'first': [1498, 2562], 'mechanism': [1499, 1719], 'cysteinerich': [1504], 'might': [1507], 'able': [1509], 'directly': [1511, 1899, 2093], 'sense': [1512, 2994, 3002], 'via': [1516, 2483], 'thiol': [1517], 'modification': [1518, 2374], 'cysteine': [1521], 'residues,': [1522], 'modifications': [1525], 'cause': [1527], 'conformational': [1529], 'change': [1530], 'releasing': [1532], '(23Bloom': [1537], 'Dhakshinamoorthy': [1539], 'Oncogene.': [1543, 2043], '2002;': [1544, 1575, 1590, 1885, 2269, 2347, 2452, 2550], '21:': [1545], '2191-2200Crossref': [1546], '(92)': [1549], '24Dinkova-Kostova': [1552], 'A.T.': [1553, 3357], 'Holtzclaw': [1554], 'W.D.': [1555], 'Cole': [1556], 'R.N.': [1557], '99:': [1576], '11908-11913Crossref': [1577], '(1583)': [1580], '25Zipper': [1583], 'L.M.': [1584, 1838, 1951], '277:': [1591, 1886, 2270, 2348, 2453], '36544-36552Abstract': [1592], '(286)': [1600], 'However,': [1603], 'it': [1604], 'debatable': [1606], 'whether': [1607, 2718, 4054], 'vitro': [1610], 'concentrations': [1613, 4260], 'oxidants': [1615], 'electrophiles': [1617], 'would': [1618], 'achievable': [1620], 'vivo': [1624], 'situation.': [1625], 'Furthermore,': [1626, 2147], 'release': [1628, 1724], 'triggered': [1637], 'some': [1639], 'signals': [1641, 1800, 2366, 2588, 2647], 'kinases': [1646], '(MAPKs)': [1647], 'C': [1651], '(PKC)': [1652], 'absence': [1655], 'modifying': [1658], 'agents': [1659], 'Under': [1681], 'homeostasis': [1682], 'conditions,': [1683], 'undergoes': [1685], 'Keap1-dependent': [1686], '-independent': [1688], 'degradation': [1689], 'proteasome': [1691], '(26McMahon': [1692], '278:': [1704, 1754, 1825, 1959, 2298, 2410], '21592-21600Abstract': [1705], '(860)': [1713], 'so': [1716], 'second': [1718], 'oxidative/electrophilic': [1732], 'increase': [1736], 'stability': [1739], '(27Nguyen': [1740, 1811], 'Sherratt': [1742, 1813], 'Huang': [1744, 1815], 'Yang': [1746, 1817], 'C.S.': [1747, 1818], '4536-4541Abstract': [1755, 1826], '(499)': [1763, 1834], 'resulting': [1766], 'accumulation': [1769], 'enhancement': [1776, 2327], 'A': [1781, 3062], 'third': [1782], 'alternative': [1783], 'hypothesis': [1784], 'specific': [1798, 1977], 'These': [1806, 4114, 4238], 'kinases,': [1807], '28Zipper': [1837], '73:': [1844], '124-134Crossref': [1845], '(211)': [1848], 'PI3K': [1851], '(22Nakaso': [1852], 'PKC': [1875], '(29Huang': [1876], '42769-42774Abstract': [1887], '(806)': [1895], 'Scholar)': [1897, 2120, 2309, 4290], 'could': [1898, 2367, 4187], '(phosphorylation': [1900], 'Nrf2)': [1902], 'indirectly': [1904], 'either': [1910], 'affecting': [1911], 'translocation': [1914], 'and/or': [1915, 2377], 'ability': [1917], 'binding': [1919, 2943, 4138, 4156], 'target': [1927, 1982], '30Zipper': [1950], '484-492Crossref': [1960], '(215)': [1963], 'Once': [1966], 'nucleus,': [1969], 'only': [1972], 'ARE': [1978], 'sequence': [1979, 3000, 3021], 'genes,': [1983], 'other': [1989, 2378, 2762, 3306, 4149], 'trans-acting': [1990, 2002], 'factors,': [2003], 'small': [2005], 'Maf': [2006], 'MafG': [2008], 'MafK': [2010], 'reported': [2013], 'dimerize': [2015], 'specifically': [2016], 'Nrf1': [2018], '(31Toki': [2021], 'Kitazawa': [2025], 'Arai': [2027], 'Hatakeyama': [2029], 'Akasaka': [2031], 'Nomura': [2035], 'Yokoyama': [2037], 'Ito': [2041], '1901-1910Crossref': [2046], '(94)': [2049], '(CBP)': [2055], 'play': [2060], 'key': [2062], 'wide': [2070], 'involved': [2075], 'AP-1,': [2082], 'p53,': [2083], 'NFκB.': [2085], 'CBP': [2090, 2153, 2318, 2376, 3291], '(32Katoh': [2099, 4269], 'Yoshida': [2103, 4273], 'Miyagishi': [2105, 4275], 'Fukamizu': [2107, 4277], 'Cells.': [2112, 4282], '6:': [2114, 3244, 4284], '857-868Crossref': [2115, 4285], '(367)': [2118, 4288], 'another': [2123, 4027], 'member': [2124], 'p160': [2126], 'ARE-binding': [2129], 'protein-1': [2130], '(33Zhu': [2131], 'Fahl': [2133, 3352], 'W.E.': [2134, 3353], '289:': [2140], '212-219Crossref': [2141], '(114)': [2144], 'previous': [2148], 'reports': [2149], 'phosphorylated': [2156, 2320], '(34Liu': [2159], 'Y.Z.': [2160, 2212], 'Chrivia': [2161, 2262, 2340], 'J.C.': [2162], 'Latchman': [2163, 2215, 2264, 2342], 'D.S.': [2164, 2216], '1998;': [2168], '273:': [2169], '32400-32407Abstract': [2170], '(86)': [2178], '35Ait-Si-Ali': [2181], 'Carlisi': [2183], 'Ramirez': [2185], 'Upegui-Gonzalez': [2187], 'L.C.': [2188], 'Duquet': [2189], 'Robin': [2191], 'Rudkin': [2193], 'B.': [2194, 2257, 2335], 'Harel-Bellan': [2195], 'Trouche': [2197], '262:': [2204], '157-162Crossref': [2205], '(120)': [2208], '36Liu': [2211], 'Thomas': [2213], 'N.S.': [2214], 'Neuroreport.': [2217], '10:': [2219], '1239-1243Crossref': [2220], '(48)': [2223, 2251], '37See': [2226], 'R.H.': [2227], 'Calvo': [2228], 'Shi': [2230], 'Kawa': [2232], 'Luke': [2234], 'M.P.': [2235], 'Yuan': [2236], 'Z.': [2237, 3134, 3158, 3229], '276:': [2242], '16310-16317Abstract': [2243], '38Gusterson': [2254], 'R.': [2255, 2333, 2515, 2671, 2675, 3296, 3317, 3347], 'Brar': [2256, 2334], 'Faulkes': [2258, 2336], 'Giordano': [2260, 2338], '2517-2524Abstract': [2271, 2349], '(91)': [2279, 2357], '39Sang': [2282], 'Stiehl': [2284, 2396], 'D.P.': [2285, 2397], 'Bohensky': [2286, 2398], 'Leshchinsky': [2288, 2400], 'Srinivas': [2290, 2402], 'V.': [2291, 2403, 2521, 3323], 'Caro': [2292, 2404], '14013-14019Abstract': [2299, 2411], '(287)': [2307, 2419], 'and,': [2310], 'particular,': [2312], 'C-terminal': [2314], 'activation': [2315], 'was': [2319, 2725, 2830, 2949, 2963, 3044, 3071, 3106, 3292, 3503, 3516, 3534, 3569, 3601, 3616, 3690, 3701, 3722, 3752, 3781, 3798, 3812, 3856, 3894, 3985, 4025, 4108, 4133, 4254], 'cascades': [2324], 'leading': [2325], '(38Gusterson': [2332], 'possible': [2363], 'posttranslational': [2373], 'unidentified': [2379], 'transacting': [2380], 'co-activators': [2383], 'machinery,': [2390], 'p300': [2393], '(39Sang': [2394], 'peroxisome': [2423], 'proliferator-activated': [2424], 'receptor': [2425], '(PPAR)-binding': [2426], '(PBP)': [2428], '(40Misra': [2429], 'Owuor': [2431, 2522, 3324], 'E.D.': [2432, 2523, 2545, 3325], 'Li': [2433, 3157, 3228], 'W.': [2434, 3160, 3351], 'Yu': [2435], 'Qi': [2437], 'Meyer': [2439], 'Zhu': [2441], 'Y.J.': [2442], 'Rao': [2443], 'M.S.': [2444], 'Kong': [2445, 2526, 2546, 3328, 3356], 'A.N.': [2446, 2527, 2547, 3329], 'Reddy': [2447], 'J.K.': [2448], '48745-48754Abstract': [2454], '(66)': [2462], 'laboratories': [2469], 'ARE-containing': [2478, 2625], '(6Alam': [2486], '41Yu': [2514], 'Chen': [2516, 3155, 3318], 'Mo': [2518, 3320], 'Y.Y.': [2519, 3321], 'Hebbar': [2520, 3322], 'Tan': [2524, 3326, 3354], '39907-39913Abstract': [2533, 3335], '(307)': [2541, 3343], '42Owuor': [2544], '64:': [2551], '765-770Crossref': [2552], '(404)': [2555], 'dissected': [2563], 'tested': [2571], 'system,': [2579], 'then': [2581, 2919, 3554, 3753, 3843], 'examined': [2582, 3952], 'acitivity': [2601], 'were': [2602, 2785, 2824, 2844, 2866, 2912, 2974, 2990, 3085, 3129, 3378, 3407, 3435, 3443, 3464, 3482, 3545, 3582, 3632, 3946, 3951, 4010, 4077], 'endogenous': [2610, 4195], 'HO-1': [2611, 2626, 2632, 2840], 'level': [2613], 'after': [2614, 3479, 3636], 'overexpression': [2615], 'corresponding': [2617], 'Nrf2-dependent,': [2630], 'one': [2634], 'most': [2637], 'readily': [2638], 'induced': [2639], '(43Maines': [2648], 'M.D.': [2649], 'FASEB.': [2650], '1988;': [2652], '2:': [2653], '2557-2568Crossref': [2654], '(1567)': [2657], '44Balogun': [2660], 'Hoque': [2662], 'Gong': [2664], 'Killeen': [2666], 'Green': [2668], 'Foresti': [2670], 'Motterlini': [2674], '371:': [2679], '887-895Crossref': [2680], '(889)': [2683], 'Our': [2686], 'unequivocally': [2689], 'positively': [2695], 'activity,': [2700, 3983], 'inhibited': [2705], 'involvement': [2710], 'led': [2714], 'us': [2715], 'investigate': [2717], 'domain.': [2733, 2944], 'observed': [2738, 4109], 'site-directed': [2740, 3383], 'had': [2744, 4032, 4166, 4226], 'little': [2745], 'stimulatory': [2756], 'RafBXB.': [2759], 'On': [2760, 4147], 'hand,': [2763, 4150], 'Raf-BXB': [2764], 'substantially': [2765], 'enhanced': [2766], 'Nrf2-interacting': [2774], 'Cell': [2777], 'Culture,': [2778], 'Antibody,': [2779], 'Chemicals—Human': [2781], 'hepatoma': [2782], 'obtained': [2786, 3087], 'ATCC': [2788], '(Manassas,': [2789], 'VA)': [2790], 'maintained': [2792], 'F-12': [2794, 3558], 'medium': [2795, 2813, 3502, 3507, 3559], 'supplemented': [2796], '10%': [2798, 3663, 3704, 3826], 'fetal': [2799], 'bovine': [2800, 3785], 'serum,': [2801], '1.17': [2802], 'g/liter': [2803], 'sodium': [2805, 3654, 3658], 'bicarbonate,': [2806], '0.1': [2807], 'units/ml': [2808, 2817], 'insulin,': [2809], '0.5×': [2810], 'minimal': [2811], 'essential': [2812], 'acid,': [2815], '100': [2816, 2820, 3673, 3828], 'penicillin,': [2818], 'μg/ml': [2821], 'streptomycin.': [2822], 'Cells': [2823, 3544], 'split': [2825], 'every': [2826], '3': [2827], 'days.': [2828], 'Sulforaphane': [2829], 'purchased': [2831, 2845, 2964], 'LKT': [2833], 'Laboratories': [2834], '(St.': [2835], 'Paul,': [2836], 'MN).': [2837], 'Goat': [2838], 'polyclonal': [2839, 3756], 'anti-actin': [2842, 3846], 'antibodies': [2843], 'Santa': [2847], 'Cruz': [2848], 'Biotechnology': [2849], '(Santa': [2850], 'Cruz,': [2851], 'CA).': [2852, 3390], 'Generation': [2853], 'Chimeras': [2856], 'Expression': [2858], 'Constructs—Four': [2859], 'amplified': [2867, 2910], 'template': [2871], '(589': [2872], 'acids)': [2874], 'polymerase': [2876], 'chain': [2877], 'reaction': [2878], 'following': [2881, 3399, 3437, 3491], 'sets': [2882], 'primers,': [2884], 'N1:': [2885], '5′-GGTACCTGGATTTGATTGACATACTT-3′': [2886, 2904], '(sense)': [2887, 2893, 2899, 2905], '5′-TCTAGAGTGACTGAAACGTAGCCGAAGAAACCTC-3′': [2889], '(antisense);': [2890, 2896, 2902], 'N2:': [2891], '5′-GGTACCCGTTTGTAGATGACAATGAGGTT-3′': [2892], '5′-TCTAGACTGTCAACTGGTTGGGGTCTTCTGTGGAGAG-3′': [2895], 'N3:': [2897], '5′-GGTACCTTCTTAATGCTTTTGAGGAT-3′': [2898], '5′-TCTAGATTCCAGGGGCACTATCTAGCTCTTC-3′': [2901, 2907], 'N4:': [2903], '(antisense).': [2908], 'fragments': [2911], 'inserted': [2913, 3051], 'pCR2.1': [2915], '(Invitrogen)': [2916, 3490], 'vector': [2917, 2928, 3055, 3542, 3992, 4043], 'subcloned': [2920], 'KpnI/XbaI': [2923], 'pSG424': [2927], '(kindly': [2929], 'provided': [2930, 2952, 3294, 3494], 'Dr.': [2932, 2954, 3089, 3093, 3110], 'Anning': [2933, 2955], 'Lin,': [2934], 'University': [2935], 'Chicago),': [2937], 'Gal-4': [2941], 'DNA': [2942, 3446, 3450, 3529], 'Gal4-luciferase': [2946, 3982], 'plasmid': [2948, 3515], 'kindly': [2951, 3086, 3293], 'Lin.': [2956], 'Full-length': [2957], 'human': [2958], 'cDNA': [2960], '(GenBank™,': [2961], 'BC002417)': [2962], 'IMAGE': [2966], 'Clone': [2967], 'Consortium': [2968], '(IMAGE': [2969], 'number:': [2970], '3163902).': [2971], 'PCR': [2972, 3042], 'primers': [2973], 'designed': [2975], 'include': [2977], 'entire': [2979], 'open': [2980], 'reading': [2981], 'frame': [2982], 'XhoI': [2986], 'HindIII': [2988], 'overhangs': [2989], 'added': [2991, 3072], 'antisense': [2996, 3023], 'primer,': [2997], 'respectively.': [2998], 'primer': [3003, 3024, 3414, 3421, 3428], 'is:': [3004, 3025], '5′-T': [3005], 'TTT': [3006], 'CTC': [3007], 'GAG': [3008], 'ATG': [3009], 'CAG': [3010], 'CCA': [3011], 'GAT': [3012], 'CCC': [3013], 'AGG': [3014], 'CCT-3′': [3015], '(XhoI': [3016], 'site': [3017, 3037], 'underlined).': [3019, 3039], '5′-TTTT': [3026], 'AAG': [3027], 'CTT': [3028], 'ACA': [3029, 3031], 'GGT': [3030], 'GTT': [3032], 'CTG': [3033, 3034], 'GTC-3′': [3035], '(HindIII': [3036], 'An': [3040, 4019], '1872-bp': [3041], 'product': [3043], 'amplified,': [3045], 'purified,': [3046], 'digested': [3047], 'XhoI/HindIII,': [3049], 'Ds-Red-express-N1': [3054], '(Clontech)': [3056], 'ProteinTech': [3058], 'Group': [3059], '(Chicago,': [3060], 'IL).': [3061], 'coral': [3063], 'Discosoma': [3064], 'sp.': [3065], 'red': [3066], 'fluorescent': [3067], '(Ds-Red)': [3069], 'tag': [3070], 'Keap1.': [3077], 'Active': [3078], 'ERK5': [3079], '(pCMV-HA-ERK5)': [3080], 'active': [3082, 3103], 'MEK5': [3083], '(pCMV-HA-MEK5)': [3084], 'Jack': [3090], 'Dixon': [3091], 'Kun-Liang': [3094], 'Guan': [3095], '(University': [3096, 3453], 'Michigan,': [3098], 'Ann': [3099], 'Arbor,': [3100], 'MI).': [3101], 'Constitutively': [3102], 'MEK1': [3104], '(DNEE-MEK1-pCDNA3)': [3105], 'gift': [3108], 'Rony': [3111], 'Seger': [3112], '(The': [3113], 'Weizmann': [3114], 'Institute': [3115], 'Science).': [3117], 'Wild-type': [3118], 'dominant-negative': [3120], 'p38α,': [3121], 'p38β,': [3122], 'p38γ,': [3123], 'p38δ,': [3124], 'constitutively': [3126], 'pCDNA3-MKK6b(E)': [3128], 'described': [3130, 3314, 3864], 'previously': [3132, 3315, 4291], '(45Li': [3133], 'Jiang': [3135, 3226], 'Ulevitch': [3137, 3236, 3271], 'R.J.': [3138, 3237, 3272], '1996;': [3145, 3170, 3200, 3216], '228:': [3146], '334-340Crossref': [3147], '(352)': [3150], '46Jiang': [3153], 'Guo': [3159], 'Gegner': [3161], 'J.A.': [3162], 'Lin': [3163, 3234], '271:': [3171], '17920-17926Abstract': [3172], '(654)': [3180], '47Lechner': [3183], 'Zahalka': [3185], 'Giot': [3187], 'J.F.': [3188], 'Moller': [3189], 'N.P.': [3190], 'Ullrich': [3191], '93:': [3201], '4355-4359Crossref': [3202], '(275)': [3205], '48Mertens': [3208], 'Craxton': [3210], 'Goedert': [3212], '383:': [3217], '273-276Crossref': [3218], '(134)': [3221], '49Huang': [3224], 'Nishida': [3230], 'Mathias': [3232], 'Nemerow': [3238], 'G.R.': [3239], 'Immunity.': [3242], '739-749Abstract': [3245], '(212)': [3253], '50Jiang': [3256], 'Gram': [3258], 'Zhao': [3260], 'New': [3262], 'L.': [3263, 3267], 'Gu': [3264], 'Feng': [3266], 'Di': [3268], 'Padova': [3269], 'F.': [3270], '272:': [3279], '30122-30128Abstract': [3280], '(432)': [3288], 'Goodman': [3298], '(Vollum': [3299], 'Institute,': [3300], 'Oregon': [3301], 'Health': [3302], 'Sciences': [3303], 'University).': [3304], 'All': [3305, 3433], 'plasmids': [3307, 3486], '(41Yu': [3316], '51Yu': [3346], 'Mandlekar': [3348], 'Lei': [3350], '2322-2327Abstract': [3363], '(181)': [3371], 'Mutagenesis—Amino': [3375], 'acid': [3376], 'replacements': [3377], 'performed': [3379, 3436, 3895], 'QuikChange': [3382], 'kit': [3385], 'Stratagene': [3387], '(La': [3388], 'Jolla,': [3389], 'construct': [3392], 'served': [3394], 'template.': [3397], 'oligonucleotides': [3400], 'containing': [3401, 3732, 3974], 'appropriate': [3403], 'codon': [3404], 'exchange': [3405], '(underlined)': [3406], 'procedure.': [3411], 'forward': [3413, 3420, 3427], 'S148A': [3416], '5′-GCTACTAATCAGGCTCAGGCACCTGAAACTTCTGTTG-3′;': [3418], 'S199A': [3423], '5′-GAGACTACCATGGTTCCAGCTCCAGAAGCCAAACTGAC-3′;': [3425], 'S243A': [3430], '5′-CAGCAGCATCCTCGCCACAGAAGACCC-3′.': [3432], 'manipulations': [3434], "manufacturer's": [3439, 3574], 'instructions.': [3440], 'mutations': [3442], 'sequencing': [3447, 3451], 'CMG': [3449], 'facility': [3452], 'Florida).': [3455], 'Transient': [3456], 'Transfection': [3457], 'Reporter': [3459], 'Gene': [3460], 'Activity': [3461], 'Assays—HepG2': [3462], 'plated': [3465], '6-well': [3467], 'plates': [3468], 'density': [3471], '4.0': [3473], '×': [3474], '105': [3475], 'cells/well.': [3476], 'Twenty-four': [3477], 'hours': [3478], 'plating,': [3480], 'transfected': [3483, 3530, 4126], 'LipofectAMINE': [3488], '2000': [3489], 'protocol': [3493, 3575], 'manufacturer.': [3497], 'brief,': [3499, 3580], 'cell': [3500, 3641, 3688], 'culture': [3501], 'changed': [3504], 'OPTI-MEM': [3506], 'before': [3508, 3565], 'each': [3509, 3523, 3532], 'transfection,': [3510, 3524], '0.5': [3511], 'μg': [3512, 3538, 3698], 'pRSV-β-galactosidase': [3514], 'cotransfected': [3517], 'transfection': [3519, 3548, 3638, 3965], 'efficiency': [3520], 'normalization': [3521], 'total': [3526], 'amount': [3527], 'adjusted': [3535], '4': [3537, 3770, 3851], 'empty': [3541], 'pCDNA3.1.': [3543], 'incubated': [3546], 'mixtures': [3549], '5': [3551, 3676, 3968], 'h': [3552, 3564, 3635], 'cultured': [3555], 'fresh': [3557], 'an': [3561], 'additional': [3562], '36': [3563, 3634], 'harvesting.': [3566], 'Luciferase': [3567], 'determined': [3570, 3691], 'according': [3571], '(Promega,': [3576], 'Madison,': [3577], 'WI).': [3578], 'washed': [3583, 3813, 3837], 'once': [3584], 'ice-cold': [3586], 'phosphate-buffered': [3587], 'saline': [3588, 3730], 'harvested': [3590, 3633], '1×': [3592, 3665], 'lysis': [3594, 3642], 'buffer.': [3595], 'After': [3596, 3773, 3806], 'centrifugation,': [3597], '10-μl': [3599], 'supernatant': [3600], 'assayed': [3602], 'luciferase': [3604, 3614, 3876], 'Sirius': [3608], 'luminometer': [3609], '(Berthold': [3610], 'Detection': [3611], 'Systems).': [3612], 'normalized': [3617], 'β-galactosidase': [3619], 'concentration': [3624, 3686], 'CBP-related': [3627], 'experiments.': [3628, 3891], 'Western': [3629], 'Blotting—HepG2': [3630], 'transient': [3637], 'whole': [3640], 'buffer': [3643, 3820], '(10': [3644], 'mm': [3645, 3650, 3653, 3657, 3670, 3680, 3734, 3822, 3829], 'Tris-HCl,': [3646, 3735, 3823], 'pH': [3647, 3736, 3824], '7.9,': [3648], '250': [3649], 'NaCl,': [3651, 3740], '30': [3652, 3697, 3832], 'pyrophosphate,': [3655], '50': [3656, 3835, 4093], 'fluoride,': [3659, 3672], '0.5%': [3660], 'Triton': [3661], 'X-100,': [3662], 'glycerol,': [3664], 'proteinase': [3666], 'inhibitor': [3667], 'mixture,': [3668], '1': [3669, 3748, 3794], 'phenylmethylsulfonyl': [3671], 'μm': [3674, 3677, 4209], 'Na3VO4,': [3675], 'ZnCl2,': [3678], 'indole': [3681], 'acetic': [3682], 'acid).': [3683], 'lysates': [3689], 'Bradford': [3694], 'method,': [3695], 'resolved': [3702], 'SDS-polyacrylamide': [3705], 'gel': [3706], 'electrophoresis': [3707], 'transferred': [3709], 'polyvinylidene': [3711], 'difluoride': [3712], 'membrane': [3713, 3721, 3751, 3780, 3811], 'semi-dry': [3716], 'transfer': [3717], '(Fisher).': [3719], 'blocked': [3723], '5%': [3725], 'nonfat': [3726, 3764], 'milk': [3727, 3765], 'Tris-buffered': [3729], '(TBST,': [3731], '20': [3733], '7.6,': [3737], '8': [3738], 'mg/ml': [3739], '0.2%': [3742], 'Tween-20)': [3743], 'room': [3745, 3791], 'temperature': [3746, 3792], 'h.': [3749, 3795], 'probed': [3754], 'goat': [3757], 'anti-HO-1': [3758], 'antibody': [3759, 3787, 3847], '(1:200': [3760], 'dilution)': [3761, 3789], '3%': [3763], '(dissolved': [3766], 'TBST)': [3768], '°C': [3771], 'overnight.': [3772], 'washing': [3774], 'times': [3776], 'TBST,': [3778, 3841], 'blotted': [3782], 'peroxidase-conjugated': [3784], 'anti-goat': [3786], '(1:5000': [3788], 'detected': [3799, 3857], 'ECL': [3802], '(Amersham': [3804], 'Biosciences).': [3805], 'developing': [3807], 'film,': [3809], 'TBST': [3815], 'twice': [3816, 3838], 'stripped': [3818], '(62.5': [3821], '6.5,': [3825], 'SDS,': [3827], 'β-mercaptoethanol)': [3830], 'min': [3833], '°C,': [3836], 'again': [3839], 're-probed': [3844], '(1:1000)': [3848], 'overnight': [3849], '°C.': [3852], 'actin-specific': [3854], 'band': [3855], 'manner': [3860], 'similar': [3861], 'HO-1.': [3866], 'Statistics—Values': [3867], 'given': [3869], 'relative': [3873], 'unstimulated': [3878], '(set': [3880], '1).': [3882], 'Values': [3883], 'expressed': [3885], 'mean': [3887], '±': [3888], 'S.D.': [3889], 'Statistical': [3892], 'analysis': [3893], 'two-tailed': [3898], "Student's": [3899], 't': [3900], 'test': [3901], 'unpaired': [3903], 'data,': [3904], 'p': [3906], 'value': [3907], '<0.05': [3908], 'considered': [3909], 'statistically': [3910], 'significant.': [3911], 'Transactivation': [3912], 'Potential': [3913], 'Different': [3915], 'Chimeras—To': [3917], 'delineate': [3918], 'biological': [3920], 'functions': [3921], 'domains': [3925, 4297], '1–370': [3929], 'region,': [3932], 'series': [3934], 'fusion': [3937], 'constructs,': [3938], 'schematically': [3941], 'Fig.': [3944, 4048], '1A': [3945], 'generated.': [3947], 'Their': [3948], 'At': [3963], 'dose': [3966], 'ng,': [3969], '(N4)': [3973], 'about': [3986, 4217], '100-fold': [3987], 'compared': [3989, 4014, 4183], 'control': [3993], '(Fig.': [3994, 4081, 4219], '1B).': [3995], 'contrast,': [3997], 'truncated': [4003, 4028], '(N1)': [4006], '(N3)': [4009], 'N4.': [4018, 4198], 'interesting': [4020], 'finding': [4021], 'experiment': [4024], '(N2)': [4031], 'even': [4035, 4257], 'higher': [4036, 4178, 4259], 'than': [4037], 'N4': [4040, 4076, 4119, 4215], '(1000-fold': [4041], 'control)': [4044], '1B.': [4049], 'verify': [4053], 'acts': [4058], 'similarly': [4059, 4121], 'cells,': [4065], 'N2': [4074, 4112, 4152, 4234], 'tested.': [4078], '1C)': [4082], 'coexpression': [4085, 4163], 'doses': [4089], '25': [4091], 'ng': [4094], 'significantly': [4096], 'suppress': [4097], 'N4,': [4103, 4185], 'suppression': [4107, 4247], 'chimera.': [4113], 'observations': [4115], 'behaved': [4120], 'suppressed': [4134], 'because': [4135, 4151], 'subsequent': [4142], 'retention': [4143], 'cytoplasm.': [4146], 'lacked': [4153], 'ETGE': [4158], 'N': [4161], 'terminus,': [4162], 'This': [4173], 'explained': [4175], 'N2,': [4181], 'due': [4189], 'suppressing': [4192], 'expected,': [4200], 'treatments': [4201, 4225, 4243], 'sulforaphane': [4205], '(SFN)': [4206], '12.5': [4208], 'increased': [4210], '2-fold': [4218], '1C),': [4220], 'same': [4223], 'SFN': [4224, 4242, 4262], '(data': [4235, 4263], 'shown).': [4237, 4265], 'reversed': [4244], 'N4;': [4250], 'however,': [4251], 'reversal': [4253], 'never': [4255], 'complete': [4256], 'et': [4267], 'al.': [4268], 'Neh4': [4294], 'Neh5': [4296], 'within': [4298], '(amino': [4301], '1–317)': [4303], 'possessed': [4306], 'independent': [4307]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2135655204', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 9}, {'year': 2018, 'cited_by_count': 6}, {'year': 2017, 'cited_by_count': 6}, {'year': 2016, 'cited_by_count': 11}, {'year': 2015, 'cited_by_count': 8}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 10}, {'year': 2012, 'cited_by_count': 17}], 'updated_date': '2024-12-10T09:57:30.537860', 'created_date': '2016-06-24'}