Publication Information

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1581, 1592, 1625, 1634, 1662, 1666, 1715, 1728, 1784, 1825, 1843, 1855, 1896, 1909, 1924, 1948, 1959, 2014, 2042, 2060, 2069, 2090, 2134, 2139, 2141, 2155, 2229, 2246, 2270, 2281, 2303, 2310, 2312, 2336, 2374, 2405, 2423, 2467, 2506, 2516, 2529, 2538, 2552, 2601, 2682, 2718, 2723, 2728, 2752, 2807, 2839, 2843, 2848, 2853, 2860, 2872, 2891, 2940, 2988, 3012, 3059, 3081, 3103, 3108, 3117, 3122, 3143, 3148, 3178, 3205, 3233, 3250, 3261, 3267, 3286, 3292, 3311, 3315, 3328, 3340, 3345, 3392, 3397, 3424, 3429, 3439, 3460, 3472, 3481, 3488, 3496, 3525, 3538, 3540, 3549, 3563, 3587, 3595, 3602, 3623, 3704, 3712, 3716, 3730, 3754, 3765, 3790, 3805, 3828, 3847, 3903, 3907, 3914, 3934, 3957, 3965, 3971, 4021, 4026, 4044, 4065, 4093, 4118, 4125, 4136, 4172, 4194, 4201, 4230], 'Traditional': [36], 'Factors': [38], 'and': [39, 49, 62, 79, 89, 95, 120, 137, 147, 153, 164, 176, 193, 203, 209, 289, 322, 336, 346, 372, 393, 434, 451, 481, 484, 514, 636, 677, 686, 700, 708, 735, 766, 807, 815, 825, 846, 857, 970, 1007, 1027, 1029, 1060, 1073, 1120, 1126, 1221, 1236, 1280, 1311, 1438, 1442, 1453, 1487, 1531, 1665, 1696, 1709, 1718, 1741, 1904, 1940, 1970, 2037, 2094, 2124, 2293, 2301, 2329, 2352, 2376, 2390, 2413, 2443, 2663, 2731, 2790, 2863, 2917, 2935, 2963, 3247, 3263, 3344, 3385, 3436, 3510, 3609, 3614, 3655, 3702, 3728, 3798, 3826, 3973, 4040, 4073, 4116, 4134, 4158, 4161, 4164, 4175, 4178, 4215, 4255], 'Noninvasive': [40, 3445], 'Cardiovascular': [41, 77, 135, 191, 892], 'Tests': [42], 'Philip': [43, 53, 3619], 'Greenland,': [44, 3620], 'Sidney': [45, 107], 'C.': [46, 108, 111], 'Smith': [47, 109, 112, 3665, 4244, 4267], 'Jr': [48, 113], 'Scott': [50, 165], 'M.': [51, 166, 168], 'Grundy': [52, 169, 3669, 3988, 4009, 4226], 'GreenlandPhilip': [54], 'Greenland': [55, 3667, 3986, 4013], 'From': [56, 114, 170], 'the': [57, 71, 90, 115, 129, 148, 171, 185, 204, 241, 273, 325, 334, 341, 365, 375, 379, 384, 421, 436, 525, 552, 562, 575, 618, 634, 637, 658, 716, 730, 772, 907, 910, 1052, 1063, 1086, 1114, 1136, 1140, 1227, 1255, 1259, 1273, 1344, 1368, 1378, 1395, 1401, 1410, 1458, 1503, 1519, 1527, 1560, 1569, 1590, 1597, 1601, 1606, 1759, 1769, 1867, 1891, 1897, 1901, 1905, 1910, 1982, 1993, 2038, 2067, 2160, 2219, 2252, 2304, 2359, 2372, 2406, 2417, 2450, 2464, 2476, 2527, 2643, 2649, 2685, 2750, 2753, 2762, 2799, 2805, 2870, 2882, 2904, 2944, 2995, 3001, 3016, 3021, 3031, 3104, 3123, 3127, 3140, 3154, 3176, 3243, 3248, 3338, 3393, 3427, 3461, 3469, 3479, 3494, 3518, 3531, 3536, 3541, 3546, 3557, 3603, 3611, 3681, 3713, 3717, 3824, 3858, 3966, 3996, 4036, 4041, 4063, 4099, 4126, 4199, 4282], 'Departments': [58, 91, 116, 149, 172, 205], 'Preventive': [60, 118, 174, 3624], 'Medicine': [61, 119, 175], 'Medicine,': [63, 80, 97, 121, 138, 155, 177, 194, 211, 3625], 'Northwestern': [64, 122, 178, 3626], 'University': [65, 81, 98, 123, 139, 156, 179, 195, 212, 3627], 'Medical': [66, 102, 124, 160, 180, 216, 3628], 'School,': [67, 125, 181, 3629], 'Chicago,': [68, 126, 182, 3637], 'Ill': [69, 127, 183], '(P.G.);': [70, 128, 184], 'Division': [72, 130, 186], 'Cardiology,': [74, 132, 188, 855], 'Center': [75, 133, 189], 'for': [76, 134, 190, 243, 277, 302, 390, 508, 518, 544, 594, 623, 902, 1081, 1097, 1302, 1409, 1467, 1551, 1730, 1736, 1743, 1752, 1946, 1984, 2026, 2103, 2137, 2218, 2308, 2403, 2777, 2785, 2801, 2932, 2997, 3030, 3097, 3157, 3196, 3235, 3245, 3257, 3270, 3278, 3304, 3380, 3390, 3447, 3499, 3559, 3567, 3684, 3905, 4032, 4168], 'Science': [78, 136, 192], 'North': [83, 141, 197], 'Carolina': [84, 142, 198], 'at': [85, 143, 199, 298, 771, 951, 1019, 1188, 1254, 1489, 1547, 1617, 2257, 2596, 2656, 2772, 3049, 3983, 4053, 4090], 'Chapel': [86, 144, 200], 'Hill': [87, 145, 201], '(S.C.S.);': [88, 146, 202], 'Clinical': [93, 151, 207], 'Nutrition': [94, 152, 208, 1237, 4216], 'Internal': [96, 154, 210], 'Texas': [100, 158, 214], 'Southwestern': [101, 159, 215], 'Center,': [103, 161, 217], 'Dallas': [104, 162, 218], '(S.M.G.).': [105, 163, 219], ',': [106], 'JrSidney': [110], 'GrundyScott': [167], 'Originally': [220], 'published9': [221], 'Oct': [222], '2001https://doi.org/10.1161/hc4201.097189Circulation.': [223], '2001;104:1863–1867At': [224], 'least': [225, 1618, 2258, 2597, 2958], '25%': [226, 1244], 'coronary': [228, 244, 293, 305, 357, 415, 472, 502, 904, 1023, 1124, 1127, 1737, 1943, 1976, 1994, 2114, 2118, 2126, 2131, 2143, 2157, 2559, 2576, 2605, 2937, 2991, 3159, 3399, 3500, 3755, 3792, 3915, 3935, 3958, 4066, 4094, 4231, 4260], 'patients': [229, 245, 285, 352, 622, 797, 926, 944, 962, 1092, 1153, 1160, 1177, 1185, 1296, 1323, 1342, 1350, 1366, 1429, 1462, 1471, 1554, 1620, 2185, 2555, 2570, 2582, 3200, 3234, 3419, 3529, 3543, 4258], 'have': [230, 475, 964, 1093, 1162, 1212, 1299, 1352, 1358, 1418, 1539, 1658, 1688, 1692, 2592, 3074, 3317], 'sudden': [231], 'death': [232, 4256], 'or': [233, 447, 459, 533, 540, 626, 698, 927, 1174, 1198, 1205, 1263, 1354, 1420, 1493, 1827, 1952, 2201, 2367, 2574, 2620, 2804, 3045, 3100, 3290, 3353, 3395], 'nonfatal': [234, 2121], 'myocardial': [235, 1122, 1953, 2122], 'infarction': [236], 'without': [237, 1037, 1283], 'prior': [238, 1325, 2153], 'symptoms.1': [239], 'Therefore,': [240, 2206], 'search': [242], 'with': [246, 364, 453, 800, 822, 826, 1178, 1203, 1324, 1330, 1643, 1651, 1684, 1711, 1794, 1872, 2105, 2147, 2151, 2556, 2571, 2580, 2583, 2604, 2616, 2713, 2746, 2885, 3042, 3133, 3164, 3412, 3493, 3758, 3762, 3794, 3800, 4237, 4259], 'subclinical': [247, 509, 1514, 3271, 3293], 'disease': [248, 295, 511, 1129, 1224, 1517, 1637, 1669, 1733, 1738, 2519, 3273, 3501, 3757, 3937, 3960], 'who': [249, 286, 963, 2100, 2520, 2829, 2833], 'could': [250, 1472, 1832, 1859, 2211, 2276, 2816, 3228], 'potentially': [251, 1860], 'benefit': [252, 1473], 'from': [253, 374, 843, 1388, 1475, 2047, 2235, 2262, 2324, 2349, 2379, 2416, 2565, 2633, 3183, 3468, 3522, 3998, 4035, 4069], 'intensive': [254, 310, 586, 1412, 2665, 2786, 2908, 2998], 'primary': [255, 391, 412, 545, 549, 1770, 3504, 3532, 3685, 3912], 'prevention': [256, 392, 406, 413, 546, 1347, 1771, 1969, 3505, 3533, 3789, 3827, 3913, 4064, 4229], 'efforts': [257], 'is': [258, 417, 600, 643, 742, 798, 913, 1111, 1383, 1483, 1499, 1629, 1640, 1847, 1887, 1962, 1987, 2029, 2053, 2256, 2288, 2322, 2347, 2363, 2385, 2393, 2430, 2438, 2447, 2739, 2770, 2781, 2794, 2914, 2920, 2984, 3126, 3332, 3426, 3476], 'critically': [259], 'important.': [260], 'The': [261, 360, 693, 722, 1627, 1830, 1885, 2022, 2736, 3145, 3265, 3284, 3551, 4122], 'American': [262, 638, 3689, 4037, 4042, 4202], "Association's": [264], '(AHA)': [265], 'Prevention': [266, 327, 427, 441, 526, 553, 773, 1528, 1561, 1570, 3553, 3674, 3753, 3768, 3811, 3861, 3956, 4275], 'V': [267, 328, 527, 554, 774, 1529, 1562, 1571, 3554], 'Conference,': [268], '"Beyond': [269], 'Secondary': [270], 'Prevention:': [271], 'Identifying': [272, 4088], 'High': [274, 818, 1746, 3705, 4119, 4137], 'Patient': [276], 'Primary': [278, 426, 3788, 4228], 'Prevention,"': [279], 'addressed': [280], 'ways': [281, 499], 'identify': [283, 582], 'more': [284, 309, 585, 743, 1421, 2669, 2966, 3165, 3334, 3560], 'are': [287, 362, 512, 592, 614, 684, 961, 1018, 1175, 1355, 1654, 1766, 2331, 2696, 2974, 3507, 3574], 'asymptomatic': [288, 397, 522, 943, 1147, 1209, 1682, 1707, 1812, 1918, 2092, 2482, 2602, 2710, 2827, 3370, 3406], 'clinically': [290], 'free': [291, 2515], 'heart': [294, 1128, 3756, 3884, 3916, 3936, 3959, 4067, 4232, 4253], '(CHD)': [296], 'but': [297, 598, 1849, 2167, 3034], 'sufficiently': [299], 'high': [300, 1189, 1265, 1936, 2636, 3731], 'risk': [301, 311, 370, 394, 449, 465, 473, 519, 542, 558, 572, 580, 587, 596, 610, 663, 690, 707, 710, 737, 749, 753, 786, 793, 905, 932, 968, 974, 1021, 1035, 1039, 1079, 1096, 1141, 1182, 1190, 1215, 1262, 1289, 1301, 1334, 1361, 1374, 1403, 1413, 1422, 1437, 1477, 1492, 1586, 1615, 1727, 1755, 1785, 1801, 1838, 1882, 1944, 1961, 1977, 1983, 2002, 2082, 2204, 2216, 2228, 2298, 2461, 2492, 2551, 2560, 2577, 2606, 2631, 2651, 2666, 2744, 2759, 2767, 2769, 2787, 2874, 2879, 2890, 2955, 2971, 2983, 3028, 3057, 3118, 3132, 3151, 3156, 3181, 3194, 3219, 3226, 3279, 3306, 3312, 3330, 3378, 3434, 3449, 3565, 3590, 3612, 3615, 3878, 3939, 3999, 4002, 4023, 4092, 4235], 'a': [303, 488, 534, 606, 644, 652, 689, 712, 780, 897, 965, 1149, 1230, 1300, 1359, 1373, 1384, 1631, 1702, 1719, 1725, 1792, 2057, 2088, 2113, 2130, 2152, 2156, 2172, 2178, 2193, 2202, 2226, 2243, 2272, 2282, 2313, 2421, 2453, 2504, 2530, 2610, 2629, 2639, 2654, 2708, 2714, 2783, 2825, 2835, 2856, 2864, 2886, 2936, 2953, 2989, 3054, 3076, 3170, 3218, 3297, 3333, 3381, 3388, 3523, 3585, 3592, 4030], 'future': [304, 1949, 1985, 2314, 3382], 'event': [306, 358, 714, 2158, 2316, 3384], 'justify': [308], 'reduction': [312, 3616], 'efforts.2': [313], 'In': [314, 504, 958, 1062, 1201, 1328, 1679, 2087, 2342], 'this': [315, 733, 916, 952, 1045, 1250, 1576, 1782, 1957, 2343, 2433, 2501, 2757, 2877, 2930, 2979, 3050, 3066, 3086, 3112, 3137, 3324], 'report,': [316], 'we': [317, 1267, 2993, 3881], 'amplify': [318], 'on': [319, 496, 811, 1799, 1874, 1890, 2357, 3053, 3699, 3725, 3821, 3852, 3976, 3995, 4112, 4130, 4198, 4208], 'key': [320], 'findings': [321, 4167], 'recommendations': [323, 361, 3964], 'AHA': [326, 635, 723, 2754, 2766, 3552, 3671], 'conference,': [329, 335], 'highlight': [330], 'new': [331, 498, 1331], 'research': [332, 1565, 2050], 'since': [333, 1568], 'propose': [337, 941, 2994], 'an': [338, 570, 703, 791, 1094, 1287, 1712, 1810, 2535, 2541, 2548, 2622, 2690, 2742, 2821, 3070, 3093, 3362, 3368, 3405, 3848], 'approach': [339, 368, 630, 1577, 3336, 4061], 'use': [342, 746, 915, 1504, 1580, 2751, 3266, 3339, 3438, 3480, 3495, 3562, 4025], 'office-based': [344, 571, 595, 612, 759, 785, 1144, 1288, 1369, 2237, 2691, 2743, 3564], 'testing': [345, 929, 1482, 1541, 1583, 2480, 2525, 2674, 2815, 2926, 3269, 3446], 'additional': [347, 627, 1284], 'noninvasive': [348, 506, 1507, 1582, 2273, 2360, 2407, 2444, 2792, 2814, 3268, 3341, 3364, 3572], 'procedures': [349], 'selected': [351, 467, 1864], 'better': [354, 3298, 3882], 'define': [355, 2798], 'their': [356, 1034, 1434], 'risk.': [359, 1225, 1549, 2637], 'concordant': [363], 'recently': [366], 'released': [367], 'assessment': [371, 395, 520, 543, 559, 573, 794, 955, 1040, 1145, 1370, 1802, 2003, 2745, 2793, 2875, 3280, 3331, 3435, 3450, 3487, 3566, 3613, 4000, 4020, 4028, 4236], 'management': [373, 3423], 'third': [376, 1363, 3714], 'report': [377, 2499, 3715, 4124], 'Adult': [380], 'Treatment': [381, 816, 3703, 3737, 4117, 4135], 'Panel': [382, 3698, 3738], 'National': [385, 809, 1234, 3718, 4110, 4128, 4213], 'Cholesterol': [386, 848, 3707, 3719], 'Education': [387, 849, 3720], 'Program': [388, 850, 3721], '(ATP-III).3Enthusiasm': [389], 'people': [398, 1017, 1210, 1820, 1919], 'has': [399, 486, 899, 1971, 2834, 3451, 3514], 'been': [400, 476, 487, 900, 1689, 1973, 2593, 3075, 3452], 'spurred': [401], 'by': [402, 420, 435, 632, 651, 739, 2295, 2411, 3120, 3455, 4024], 'recent': [403, 1231, 2498], 'advances': [404], 'research.': [407], 'Lipid-lowering': [408], 'trials': [409], 'demonstrated': [410, 1926], 'that': [411, 493, 557, 942, 1044, 1269, 1320, 1424, 1446, 1535, 1648, 1927, 1965, 1981, 1990, 2056, 2075, 2191, 2197, 2420, 2489, 2614, 2973, 2978, 2987, 3361, 3478, 3580], 'events': [416, 1024, 1305, 1664, 1671, 1986, 2144, 3160, 3793, 3854], 'feasible,': [418, 1484], 'evidenced': [419], 'West': [422, 3764], 'Scotland': [424, 891, 3766], 'Study': [428, 442, 863, 877, 1117, 3769, 3863], '(WOSCOPS)': [429], 'trial4': [430], 'hypercholesterolemic': [432], 'men': [433, 450, 1708, 2093, 2483, 2510, 2603, 3013, 3761, 3797, 4177], 'Air': [437, 3807], 'Force/Texas': [438, 3808], 'Atherosclerosis': [440, 3810], '(AFCAPS/TexCAPS)': [443], 'trial5': [444], 'average': [446, 1713, 2106, 3193, 3801], 'typical': [448, 2990], 'women': [452, 1710, 2095, 3799], 'only': [454], 'moderate': [455], 'lipid': [456, 3350, 3908], 'abnormalities.': [457], 'Aspirin6': [458], 'ACE': [460, 3354], 'inhibitors7': [461], 'can': [462, 538, 695, 1030, 1066, 1075, 1154, 1161, 1277, 1878, 2063, 2079, 2239, 2400, 2484, 2627, 2647, 2660, 2675, 3880], 'also': [463, 1463, 1687, 1879, 2000, 2080, 2485, 2921], 'reduce': [464, 1219, 2969], 'asymptomatic,': [468], 'high-risk': [469, 1208, 1295, 1804, 2763, 2905, 3682, 3856, 4283], 'people.': [470], 'Emerging': [471], 'factors': [474, 664, 750, 754, 975, 1216, 1423, 1756, 2578, 2972, 3029], 'described': [477, 1380, 3443], 'including': [478, 665, 805, 922, 2116], 'inflammatory,': [479], 'infectious,': [480], 'thrombotic': [482], 'markers,8': [483], 'there': [485], 'steady': [489], 'flow': [490], 'reports': [492], 'focus': [494], 'attention': [495], 'potential': [497, 3558], 'predicting': [501, 579], 'risk.9': [503], 'addition,': [505], 'tests': [507, 537, 1508, 2408, 3110, 3483, 3498, 3573], 'atherosclerotic': [510, 1013, 1169, 3167, 3272, 3287], 'available': [513, 593, 1853, 2305, 2698, 3982, 4052], 'becoming': [515], 'widely': [516, 1852], 'promoted': [517], 'patients.': [523, 1845, 3474, 3598], 'Accordingly,': [524], 'Conference': [528, 555, 1572, 3555, 3672, 4276], 'examined': [529], 'whether': [530, 2358, 3526], 'current': [531, 801, 4100], 'techniques': [532], 'combination': [535], 'optimize': [539], 'improve': [541, 2001, 2081, 3486, 3608], 'CHD.A': [548], 'recommendation': [550], 'was': [556, 1524, 1533, 2145], 'begins': [560], "physician's": [563], 'office,': [564, 909], 'where': [565], 'all': [566, 796, 1213, 1731, 2183], 'adults': [567, 1247, 3735, 4089, 4203], 'should': [568, 1211, 1337, 1430, 1538, 3018, 3372, 3581], 'undergo': [569], 'as': [574, 605, 649, 657, 762, 779, 1118, 1157, 1935, 1937, 2339, 2679, 3217, 3349, 3375, 3387, 3442, 3584], 'initial': [576, 792, 2236, 3568], 'step': [577, 912, 2738], 'those': [583, 1650, 2009], 'needing': [584], 'reduction.': [588, 4003], 'Numerous': [589], 'approaches': [590, 3604], '(Table)': [591], 'assessment,9–11': [597], 'none': [599, 777], 'yet': [601, 1416, 1851, 3376], 'considered': [602, 770, 1356, 1630, 1757, 2678, 3583], 'ideal.9,12': [603], 'However,': [604, 2016], 'first': [607, 2737], 'approximation': [608], 'prediction,': [611], 'measures': [613, 3310, 3506], 'essential': [615], 'begin': [617], 'process': [619], 'selecting': [621, 1552], 'further': [624, 928, 1038, 1078, 1281, 1476, 1490, 1540, 2215, 2683, 2791, 2925, 3588], 'intervention': [625, 2668, 3308, 3656], 'testing.': [628, 1041], 'One': [629], 'endorsed': [631], 'both': [633, 1025], 'College': [639, 4043], 'Cardiology': [641], '(ACC)': [642], 'determination': [645], '"global': [647, 736], 'risk"': [648], 'measured': [650, 685], 'multifactorial': [653], 'statistical': [654], 'model': [655], 'such': [656, 761, 1481, 1553, 2184, 2808, 3302, 3348, 3482, 3497], 'Framingham': [659, 967, 1089, 1115, 1293, 1760, 2873, 3124, 3210], 'Score.13': [661], 'Well-established': [662], 'age,': [666, 2097, 2512, 3085], 'sex,': [667], 'smoking': [668], 'history,': [669], 'blood': [670, 678, 986, 992, 1199, 1594, 1603, 2715, 2734, 2836, 2867, 2918, 3046, 3732], 'pressure,': [671], 'total': [672, 977, 1222, 2720, 2841], 'serum': [673, 1196, 2721], 'cholesterol,': [674, 676], 'HDL': [675, 981, 2726, 2851], 'glucose': [679, 1000], '(or': [680], 'history': [681, 1010, 2859], 'diabetes)': [683], 'entered': [687], 'into': [688, 946, 2761, 2881, 2903], 'calculation': [691], 'model.': [692], 'procedure': [694], 'be': [696, 1031, 1067, 1155, 1187, 1278, 1338, 1431, 1465, 1546, 1787, 1834, 1861, 2020, 2064, 2212, 2388, 2396, 2401, 2661, 2677, 2947, 3009, 3038, 3092, 3276, 3296, 3358, 3373, 3410, 3491, 3582], 'paper-based3,14': [697], 'computer-based3,13': [699], 'results': [701, 1566, 2210, 2591, 3403, 3416, 3466, 3804], 'estimation': [704, 3119], 'relative': [706, 1726, 1747, 1764, 1774, 1933, 1960, 2550], 'absolute': [709, 903, 1095, 3131], 'cardiac': [713, 3650], 'near': [717], 'term': [718], '(eg,': [719], '10': [720, 1107, 2165, 2170, 2232, 2249, 2426, 2441, 2568, 2775, 2961, 3063], 'years).': [721], 'offers': [724], 'materials': [725], 'assist': [727], 'physicians': [728], 'performance': [731], 'task,13': [734], 'assessment"': [738], 'these': [740, 1091, 1341, 1841, 2142, 2705, 2747], 'methods': [741], 'quantitative': [744], 'than': [745, 1102, 1307, 1314, 1622, 1822, 1921, 2011, 2187, 3309], 'categoric': [748], 'alone.15': [751], 'Newer': [752], 'not': [755, 935, 1406, 1556, 1850, 2030, 2054, 2332, 2697, 2795, 2831, 2901, 2915, 2922, 3037, 3091, 3386, 3409, 3490], 'included': [756], 'standard': [758, 1753, 2296], 'tools,': [760], 'homocysteine,': [763], 'C-reactive': [764], 'protein,': [765], 'lipoprotein': [767], '(a),': [768], 'were': [769, 1555, 2101, 2927, 2942, 3004], 'Conference2,8;': [775], 'however,': [776, 3079], 'emerged': [778], 'convincing': [781], 'means': [782, 2681, 3121, 3586], 'improving': [784], 'assessment.': [787, 2692, 3657], 'Advice': [788], 'perform': [790, 2741], 'consistent': [799], 'clinical': [802, 938, 1166, 2034, 2070, 2517, 3251, 3962], 'practice': [803], 'guidelines': [804, 3256, 4102], 'ATP-III3': [806, 1204], 'Joint': [808, 3968, 4109, 4127], 'Committee': [810, 4111, 4129], 'Prevention,': [812, 4113, 4131], 'Detection,': [813, 3700, 4114, 4132], 'Evaluation,': [814, 3701, 4115, 4133], 'Blood': [819, 3706, 4120, 4138], 'Pressure': [820], '(JNC)-VI,16': [821], 'European': [823, 3972], 'Guidelines11': [824], 'AHA/ACC': [827, 4017], 'recommendations.13Table': [828], '1097189.': [829], 'Examples': [830], 'Approaches': [832], 'With': [836, 2534, 2749], 'Multiple': [837], 'Factors**Derived': [842], 'References': [844, 2291], '9': [845, 2292], '34.National': [847], 'Guidelines': [851], '(NCEP)European': [852], 'Societies': [853, 3975], 'Atherosclerosis,': [856], 'HypertensionFramingham': [858], 'ScoreBritish': [860], 'Regional': [861], '(BRHS)': [864], 'ScoreSheffield': [866], 'TablesGREAT': [869], '(General': [870], 'Rule': [871], 'Enable': [873], 'Atheroma': [874], 'Treatment)Munster': [875], '(PROCAM)': [878], 'ScoreDundee': [880], 'DiscNational': [883], 'Foundation': [885], 'New': [887, 1564], 'Zealand': [888], 'GuidelinesWest': [889], 'Event': [893], 'Reduction': [894], 'Tool': [895], '(CERT)After': [896], 'patient': [898, 1793, 2646, 2688, 2702, 2818, 3022, 3569, 3683, 4284], 'assessed': [901], "doctor's": [908], 'next': [911], 'information': [917, 2488], 'determine': [919], 'appropriate': [920], 'interventions': [921, 3347, 3441], 'reassurance': [923, 2659], 'low-risk': [925, 1455], 'when': [930, 1638, 2251, 2435], 'estimated': [931, 2289, 2771, 2888, 2982], 'level': [933, 1783, 1958, 2194, 2655, 2717, 2838, 2913], 'does': [934, 2830, 2900], 'provide': [936], 'clear': [937, 2055], 'direction.': [939], 'We': [940, 1042, 1780, 3599], 'fall': [945, 2902], '3': [947, 2117], 'reasonably': [948], 'distinct': [949], 'categories': [950, 1379, 1842], 'point': [953, 2502, 2537], '(Figure': [956], '1).': [957, 2897], 'one': [959, 1677, 2017, 2140, 2302, 3035], 'category': [960, 1151, 1364, 2764, 2906, 2956], 'low': [966, 1020, 1685, 1720, 3106], 'score': [969, 2133, 2174, 2255, 2939, 3003, 3173], 'no': [971, 997, 1008, 2557], 'identifiable': [972], 'CHD': [973, 1110, 1181, 1214, 1220, 1326, 1353, 1360, 1436, 1663, 1695, 2283, 2297, 2315, 2460, 2539, 2893, 3322, 3425], '(nonsmoking,': [976], 'cholesterol': [978, 982, 1197, 2722, 2727, 2842, 2847, 2852, 2912, 3733, 3802, 4101], '≤200': [979], 'mg/dL,': [980, 984, 2725, 2730, 2845, 2850, 2855], '>40': [983], 'systolic': [985, 1593, 1602], 'pressure': [987, 993, 1595, 1604, 2716, 2837, 2919], '<120': [988], 'mm': [989, 995], 'Hg,': [990, 996], 'diastolic': [991], '<80': [994], 'evidence': [998, 1500], 'intolerance,': [1001], 'body': [1002], 'mass': [1003], 'index': [1004, 1588], '<25': [1005], 'kg/m2,': [1006], 'family': [1009, 2858], 'premature': [1012], 'vascular': [1014, 1515, 1856, 2861], 'disease).': [1015], 'These': [1016, 1159, 1763], 'short-term10': [1026], 'long-term17': [1028], 'reassured': [1032], 'about': [1033, 1433, 3023], 'status': [1036, 1456, 2632, 2652], 'estimate': [1043, 1268, 2326, 2462, 3058], '"low-risk"': [1046], 'group': [1047, 1404, 3594], 'constitutes': [1048], 'approximately': [1049, 1082, 1243, 1270, 3060], '35%': [1050, 3011], 'US': [1053, 1246, 1274, 1396], 'adult': [1054, 1275, 1397, 4174], 'population': [1055, 1276, 1680, 2505], '20': [1056], 'years': [1057, 1624, 1717, 1824, 1923, 2013, 2166, 2233, 2250, 2427, 2442, 2776, 3260, 3521], 'age': [1059, 1714, 1826, 1925, 3113, 3149, 3172, 3197, 3216, 3262, 3325], 'over.18': [1061], 'short-term,': [1064], 'they': [1065, 1074, 1417], 'offered': [1068, 1439], 'general': [1069, 1440], 'public': [1070], 'health': [1071, 2532], 'recommendations,': [1072], 'usually': [1076], 'avoid': [1077], 'assessments': [1080, 1285], '5': [1083, 4169], 'years.3': [1084], 'On': [1085, 1226, 2371, 2449, 2869], 'basis': [1087, 1228, 2373, 2871], 'data,10': [1090], '"hard': [1098, 1303], 'CHD"': [1099, 1304], 'less': [1101, 2664], '5%': [1103], '6%': [1105, 2230], 'years.': [1108, 3064], 'Hard': [1109], 'defined': [1112, 1558], 'recognized': [1119], 'unrecognized': [1121], 'infarction,': [1123], 'insufficiency,': [1125], 'death.10Download': [1130], 'figureDownload': [1131, 2266], 'PowerPointFigure': [1132, 2267], '1.': [1133], 'Flow': [1134], 'chart.At': [1135], 'other': [1137, 1165, 1180, 1667, 2451, 2599, 3974], 'end': [1138, 2536], 'spectrum,': [1142], 'following': [1143, 1367], 'people,': [1148], 'second': [1150, 2810], 'identified': [1156], '"high-risk."': [1158], 'established': [1163], 'CHD,': [1164], 'forms': [1167], 'disease,': [1170, 1647, 2862], 'type': [1171], '2': [1172, 1256, 2223, 2598], 'diabetes,': [1173], 'older': [1176, 1621, 1821, 1920, 2010, 3189, 3223, 3282], 'multiple': [1179], 'factors.': [1183, 2561], 'Some': [1184, 1460], 'may': [1186, 1999, 3201, 3295], 'because': [1191, 3080, 3102, 3209, 3459], 'extreme': [1193], 'elevations': [1194], 'pressure.': [1200], 'accordance': [1202], 'JNC-VI16': [1206], 'guidelines,': [1207, 1333], 'treated': [1217, 1282], 'cardiovascular': [1223, 1668, 1732, 1950, 2518, 3342, 3383, 3829, 3853, 3877, 4022, 4160], 'analysis': [1232], 'Health': [1235, 4214], 'Examination': [1238, 4217], 'Survey': [1239], '(NHANES)': [1240], 'III': [1241, 1390, 4211], 'data,': [1242, 1391], 'belong': [1248], '"high-risk"': [1251], 'category.18': [1252], 'Thus,': [1253, 1996, 2150, 2608], 'ends': [1257], 'spectrum': [1260], '(low': [1261], 'definitely': [1264], 'risk),': [1266], '60%': [1271], 'risk-stratified': [1279], 'beyond': [1286, 3677, 4278], 'analysis.': [1290], 'According': [1291], 'data,13': [1294], 'would': [1297, 2176, 2946, 3008, 3036, 3090], 'typically': [1298], 'greater': [1306, 1313, 2186, 2658], '2%': [1308, 2188], 'per': [1309, 1316, 2189], 'year': [1310], 'frequently': [1312], '3%': [1315], 'year,': [1317, 2190], 'similar': [1318, 1963, 1988, 2058, 2195, 2581, 2612, 2694, 3414], 'seen': [1321, 1776, 1966, 1991, 2615], 'events.10,19': [1327], 'concert': [1329], 'ATP-III': [1332], 'factor': [1335, 1414, 2299, 2667, 2788, 3307, 3379, 3940], 'targets': [1336], 'identical': [1339], "AHA's": [1345], 'secondary': [1346, 1778, 1968, 2199, 3678, 4279], 'guidelines.20': [1348], 'Such': [1349, 1428], 'either': [1351], 'equivalent.3The': [1362], 'falls': [1371, 2760, 2880], 'zone': [1375, 2884], 'intermediate': [1376, 1402, 1435, 1548, 2161, 2634], 'between': [1377], 'above.': [1381], 'This': [1382, 3239], 'sizable': [1385], 'group,': [1386], 'judging': [1387], 'NHANES': [1389, 4210], 'roughly': [1392], '40%': [1393], 'population.18': [1398], 'Patients': [1399, 1642], 'do': [1405, 4098], 'currently': [1407], 'qualify': [1408], 'most': [1411, 1474], 'interventions,20': [1415], '1': [1419, 1894, 1907], 'exceed': [1425], 'desirable': [1426], 'levels.': [1427], 'counseled': [1432], 'dietary': [1441], 'life': [1443, 4165], 'habit': [1444], 'advice': [1445], 'might': [1447, 3073], 'influence': [1448, 2817], 'them': [1449], 'change': [1451], 'behaviors': [1452], 'achieve': [1454], 'future.': [1459], 'intermediate-risk': [1461, 1520, 1844, 2005, 2085, 2220, 2495, 2644, 2686, 2822, 3597], 'will': [1464, 3174], 'candidates': [1466], 'cholesterol-lowering': [1468], 'drugs.': [1469], 'Intermediate-risk': [1470], 'stratification': [1478, 1883, 2217, 2493], 'testing,': [1479], 'if': [1480, 1542], 'practical,': [1485], 'targeted,': [1486], 'effective': [1488, 1496], 'defining': [1491], 'motivating': [1495], 'behavioral': [1497], 'changes.There': [1498], 'support': [1502, 1574], 'various': [1506], 'silent': [1510], 'ischemia': [1511], 'and/or': [1512], 'occlusive': [1516], 'population.': [1521], 'Relevant': [1522], 'literature': [1523], 'reviewed': [1525, 2409], 'Conference,21,22': [1530], 'it': [1532, 1639, 3007], 'concluded': [1534], '"selected': [1536], 'patients"': [1537], 'initially': [1543], 'found': [1544, 1690], 'Boundaries': [1550], 'clearly': [1557, 3360], 'Conference.': [1563], 'published': [1567], 'add': [1573], 'selective': [1579, 3335, 3437], 'enhance': [1585], 'assessment.Ankle-brachial': [1587], '(ABI),': [1589], 'ratio': [1591, 3548], 'ankle': [1598], 'arteries': [1599], 'brachial': [1607], 'arteries,': [1608], 'provides': [1609, 1814], 'incremental': [1610, 1815, 1881], 'prognostic': [1611, 1816, 2487, 2590], 'utility': [1612], 'over': [1613, 1939], 'traditional': [1614, 1942], 'factors,': [1616, 1945, 3313], '60': [1623, 1823], 'age.': [1626, 2015, 3135], 'ABI': [1628, 1686, 1721, 1831, 3101], 'reliable': [1632], 'sign': [1633], 'peripheral': [1635, 1645], 'arterial': [1636, 1646], '<0.90.': [1641], 'symptomatic': [1644, 3418, 3473], 'is,': [1649, 2192], 'intermittent': [1652], 'claudication,': [1653], 'well': [1655, 4097], 'known': [1656], 'markedly': [1659, 1693, 2457], 'increased': [1660, 1675, 1694, 4091], 'risks': [1661, 1748, 1765, 1775, 1934, 2563], '(CVD)': [1670], '(up': [1672], '15-fold': [1674], 'study23).': [1678], 'studies,': [1681], 'individuals': [1683], 'total-CVD': [1697], 'risks.': [1698], 'For': [1699, 2129], 'example,': [1700, 2344], 'long-term,': [1703], 'prospective': [1704], 'study,': [1705], 'primarily': [1706], '66': [1716], 'value': [1722, 2041], '(<0.90)': [1723], 'had': [1724, 2112], '6.3': [1729], 'mortality,': [1734], '4.8': [1735], 'mortality': [1739, 4163], 'alone,': [1740], '3.1': [1742], 'all-cause': [1744], 'mortality.': [1745], 'persisted': [1749], 'after': [1750, 2689], 'adjustment': [1751], 'CVD': [1754], 'Score.23': [1762], 'similar,': [1767], 'setting,': [1772], 'prevention.19,20': [1779], 'judge': [1781], 'considerable': [1788], 'enough': [1789], 'move': [1791, 2240], 'apparent': [1795], '"intermediate': [1796], 'risk,"': [1797], 'based': [1798, 3052, 4207], 'office': [1800, 1868], 'status.': [1805], 'An': [1806], 'abnormal': [1807, 1928, 2542, 2623, 3363], 'ABI,': [1808, 2621], 'otherwise': [1811], 'patient,': [1813, 2992], 'information,': [1817], 'especially': [1818, 2007], 'smokers.': [1829], 'therefore': [1833, 1972, 2676, 2782], 'useful': [1835, 2213, 2589], 'refining': [1837], 'prediction': [1839, 2083, 2138, 3152], 'It': [1846, 1858, 2052, 3356, 3475], 'inexpensive': [1848], 'outside': [1854], 'laboratories.': [1857, 2051], 'used,': [1862], 'patients,': [1865, 2006], 'setting.Carotid': [1869], 'B-mode': [1870], 'ultrasound,': [1871, 2619], 'emphasis': [1873], 'intima-media': [1875], 'thickness': [1876], '(IMT),': [1877], 'yield': [1880, 2177, 2486], 'information.': [1884], 'examination': [1886, 2025], 'performed': [1888, 2032], 'bilaterally': [1889], 'distal': [1892], 'straight': [1893], 'cm': [1895, 1908], 'extracranial': [1898], 'common': [1899], 'carotids,': [1900], 'carotid': [1902, 1997, 2023, 2043, 2618, 3098], 'bifurcations,': [1903], 'proximal': [1906], 'internal': [1911], 'carotids.': [1912], 'Several': [1913, 3571], 'carefully': [1914], 'conducted': [1915], 'studies24–26': [1916], '50': [1922, 2012], 'IMT': [1929, 2027, 2044, 2061], 'values': [1930, 2353], 'result': [1931, 2275, 2362, 2446, 2456, 3366], '5.0,': [1938], 'above': [1941], 'occurrence': [1947], '(stroke': [1951], 'infarction)': [1954], 'events.': [1955], 'Again,': [1956], 'termed': [1974], '"a': [1975], 'equivalent"': [1978], 'signify': [1980], 'patient.3,19': [1995], 'ultrasonography': [1998], 'caveat': [2018], 'must': [2019, 3357, 3408], 'stated.': [2021], 'ultrasound': [2024, 2035, 2071, 3099], 'measurement': [2028], 'routinely': [2031], 'examinations,': [2036], 'best-validated': [2039], 'predictive': [2040], 'derives': [2045], 'exclusively': [2046], 'highly': [2048], 'quality-controlled': [2049], 'quality': [2059], 'measurements': [2062, 2300], 'derived': [2065], 'majority': [2068], 'laboratories.Recent': [2072], 'work': [2073], 'suggests': [2074], 'electron-beam': [2076], 'tomography': [2077], '(EBT)': [2078], 'patients.27': [2086], 'cohort': [2089], '1172': [2091], '(mean': [2096, 2511], '53': [2098], 'years)': [2099, 2514, 2962], 'self-referred': [2102], 'EBT,': [2104, 2617, 2934, 3069], 'follow-up': [2107], '3.6': [2108], 'years,': [2109], '39': [2110], 'subjects': [2111], 'event,': [2115], 'deaths,': [2119], '15': [2120], 'infarctions,': [2123], '21': [2125, 2553], 'artery': [2127, 3400], 'revascularizations.': [2128], 'calcium': [2132, 2173, 2254, 2938, 3002], '≥80,': [2135], 'sensitivity': [2136, 2328, 2375, 2384, 2412], '0.85': [2146, 2389], 'specificity': [2148, 2330, 2377, 2392, 2414], '0.75.': [2149, 2397], 'probability': [2154, 2180, 2245, 2279, 2286, 2311, 2320, 2346, 2437], 'range': [2162, 2466], '(>6%': [2163], '<20%': [2168], 'years),': [2171], '≥80': [2175, 2941], 'posttest': [2179, 2244, 2345], 'virtually': [2182], 'prevention,': [2200], '"coronary': [2203], 'equivalent."': [2205], 'positive': [2207, 2364, 3109], 'EBT': [2208, 2253], 'test': [2209, 2274, 2361, 2383, 2391, 2445, 2455, 2546, 2586, 2626, 2641, 3072, 3365, 3415, 3465], 'patient.': [2221, 2823], 'Figure': [2222, 2896], 'demonstrates': [2224], 'how': [2225, 2271, 2813, 4096], 'pretest-estimated': [2227], '(derived': [2234], 'testing)': [2238], 'up': [2241], '>20%': [2247], '80': [2259], '(per': [2260], 'data': [2261, 2378, 2415, 2695], 'Arad': [2263, 2380], 'et': [2264, 2381, 3751, 3786, 3844, 3899, 3931, 3954, 3992, 4015, 4153, 4191, 4250, 4273], 'al).27Download': [2265], '2.': [2268], 'Example': [2269], 'substantially': [2277, 3516], 'modify': [2278], 'estimates': [2280, 3227], 'event.': [2284], 'Pretest': [2285], '(x-axis)': [2287], '(see': [2290, 2428], '12)': [2294], 'multivariate': [2306], 'models': [2307], 'quantification': [2309], '(pretest': [2317], 'probability).': [2318], 'Posttest': [2319], '(y-axis)': [2321], 'different': [2323, 2348], 'pretest': [2325, 2350, 2436, 2465, 2471], 'whenever': [2327], 'each': [2333, 2404], '50%': [2334], '(line': [2335], 'identity': [2337], 'shown': [2338, 2469], 'hatched': [2340], 'line).': [2341, 2370], 'probability,': [2351], 'differ': [2354], 'markedly,': [2355], 'depending': [2356], '(solid': [2365], 'line)': [2366], 'negative': [2368, 2454, 2640, 2857], '(dashed': [2369], 'al,27': [2382], 'assumed': [2386, 2394], 'Similar': [2398], 'graphs': [2399], 'plotted': [2402], 'here': [2410, 3606], 'literature.': [2418], 'Note': [2419], 'threshold': [2422], '20%': [2424, 2773, 2959], 'text)': [2429], 'crossed': [2431], 'example': [2434, 2933], '>6%': [2439], 'positive.': [2448], 'hand,': [2452], 'reduces': [2458], 'predicted': [2459], 'within': [2463], 'probabilities': [2468], '(intermediate': [2470], 'risk).Despite': [2472], 'conventional': [2473], 'teaching': [2474], 'contrary,': [2477], 'exercise': [2478, 2523, 2544, 2585, 2624], 'stress': [2479, 2524, 2545, 2625, 2673, 3077], 'permits': [2490], 'refined': [2491], 'patients.28': [2496], 'A': [2497, 3901], 'illustrates': [2500, 2812], '25': [2507], '927': [2508], 'healthy': [2509], '42.9': [2513], 'underwent': [2521], 'maximal': [2522, 2543], 'context': [2528], 'preventive': [2531, 2802, 3346, 3440], 'evaluation.28': [2533], 'death,': [2540], 'yielded': [2547], 'age-adjusted': [2549], 'major': [2558, 3158], 'Relative': [2562], 'ranged': [2564], '8': [2566], '1,': [2572], '2,': [2573], '3+': [2575], 'compared': [2579], 'normal': [2584, 2732, 2865], 'results.': [2587], 'Similarly': [2588], 'reported': [2594], 'studies': [2600, 3343], 'factors.29,30': [2607], 'manner': [2611], 'advance': [2628], "patient's": [2630, 2650, 2981], 'Conversely,': [2638], 'male': [2645, 2687, 2711], 'lower': [2648], 'which': [2657, 3316], 'provided': [2662], 'confidently': [2670], 'advised.': [2671], 'Exercise': [2672], 'another': [2680, 3377], 'risk-stratifying': [2684], 'Unfortunately,': [2693], 'women.2A': [2700], 'few': [2701, 3520], 'examples': [2703], 'illustrate': [2704], 'points.': [2706], 'Consider': [2707, 2824], '52-year-old': [2709], 'smoker': [2712], '155/90,': [2719], '240': [2724], '37': [2729], 'fasting': [2733, 2866], 'glucose.': [2735, 2868], 'data.': [2748], 'Calculator,13': [2756], "person's": [2758], '(by': [2765], 'calculator,': [2768], 'hard': [2778, 2892], 'CHD).': [2779], 'He': [2780], 'candidate': [2784, 3096], 'modification,': [2789], 'required': [2796], 'need': [2800, 2996, 3244], 'therapies': [2803], 'goals': [2806], 'treatment.A': [2809], 'case': [2811], 'treatment': [2819, 3255, 3729, 3825], '50-year-old': [2826], 'man': [2828, 3089], 'smoke,': [2832], '140/85,': [2840], '210': [2844], 'LDL': [2846, 2911], '137': [2849], '32': [2854], 'scoring,13': [2876], "man's": [2878], '"intermediate"': [2883], '9%': [2887], '10-year': [2889], '(refer': [2894], 'Although': [2898, 3065], 'he': [2899], 'requiring': [2907, 4204], 'intervention,20': [2909], 'his': [2910, 2970, 3014, 3027, 3082], 'optimal,': [2916], 'optimal.': [2923], 'If': [2924, 3000], 'done': [2928], 'person,': [2931], 'found,': [2943], 'physician': [2945, 3017], 'able': [2948], 'reassign': [2950], 'him': [2951], 'higher': [2954, 3155], '(at': [2957], 'justifiably': [2964], 'proceed': [2965], 'aggressively': [2967], 'present.': [2975], 'Specifically,': [2976], 'given': [2977], 'hypothetical': [2980], 'equivalent': [2985], 'intervention.20': [2999], 'zero': [3005], '(as': [3006], 'age),': [3015], 'still': [3019], 'counsel': [3020], 'trying': [3024], 'control': [3026], 'long': [3032], 'term,': [3033], 'justified': [3039], 'intervene': [3041], 'costly': [3043], 'lipid-lowering': [3044, 4205], 'pressure–lowering': [3047], 'drugs': [3048], 'time,': [3051], 'revised': [3055], '(posttest)': [3056], '1.9%': [3061], 'illustration': [3067], 'used': [3068, 3484], 'alternative': [3071], 'ECG28;': [3078], 'relatively': [3083, 3105, 3511], 'young': [3084, 4173], '50-year': [3087], 'old': [3088], 'exceptionally': [3094], 'good': [3095], 'likelihood': [3107], 'group.A': [3114], 'prominent': [3115], 'feature': [3116], 'equation': [3125], 'progressive': [3128], 'increase': [3129, 3138], 'advancing': [3134], 'Undoubtedly,': [3136], 'reflects': [3139], 'cumulative': [3141], 'nature': [3142], 'atherogenesis.': [3144], 'powerful': [3146], 'effect': [3147], 'denotes': [3153], 'present': [3161], 'persons': [3163, 3258, 3303], 'advanced': [3166], 'disease.': [3168, 3401, 3830, 3917, 4261], 'Nonetheless,': [3169], 'single': [3171], 'mask': [3175], 'extent': [3177, 3285], 'variability': [3179], 'resulting': [3182], 'differences': [3184], 'plaque': [3186, 3288], 'burden': [3187], 'individuals.': [3190], 'To': [3191], 'apply': [3192], 'scores': [3195], 'individual': [3199], 'lead': [3202, 3229], 'miscalculation': [3204], 'true': [3206], 'risk,': [3207, 3654], 'particularly': [3208], 'applies': [3211], 'so': [3212], 'much': [3213], 'weight': [3214], 'factor.': [3220], 'Especially': [3221], 'persons,': [3224], 'Framingham-based': [3225], 'inappropriate': [3231, 3462], 'selection': [3232, 3539], 'aggressive': [3236, 3305], 'risk-reduction': [3237], 'therapies.': [3238], 'fact': [3240], 'points': [3241], 'flexibility': [3246], 'application': [3249], 'judgment': [3252], 'adapting': [3254], '65': [3259], 'older.': [3264], 'appears': [3274], 'promising': [3277], 'persons.': [3283], 'burden,': [3289], 'presence': [3291, 3394], 'ischemia,': [3294], 'way': [3299], 'select': [3301], 'some': [3314], 'diminished': [3318], 'power': [3319], 'predict': [3321, 3883], 'range.31The': [3326], 'goal': [3327, 3428], 'improved': [3329, 3448], 'lowering,': [3351], 'aspirin,': [3352], 'inhibition.': [3355], 'understood': [3359], 'intermediate-risk,': [3369], 'person': [3371, 3407], 'interpreted': [3374], 'mandate': [3389], 'diagnosis': [3391], 'absence': [3396], 'angiographic': [3398], 'Test': [3402], 'confused': [3411, 3492], 'apparently': [3413, 3596], 'whom': [3421], 'proper': [3422], 'testing—as': [3430], 'opposed': [3431], 'enhanced': [3433], 'here.': [3444], 'greeted': [3453], 'cautiously': [3454], 'critics': [3456], 'part': [3458], 'response': [3463], 'inherited': [3467], 'cardiologic': [3470], 'workup': [3471], 'crucial': [3477], 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