STAT3-Stathmin Interactions Control Microtubule Dynamics in Migrating T-cells

Name: Work Video:
Duration: 3 min 30 s
Navin Kumar Verma; Jennifer Dourlat; Anthony M. Davies; Aideen Long; Wang‐Qing Liu; Christiane Garbay; Dermot Kelleher; Yuri Volkov
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'https://openalex.org/W2128050586', 'https://openalex.org/W2130840648', 'https://openalex.org/W2151048160', 'https://openalex.org/W2153527917', 'https://openalex.org/W2156820197', 'https://openalex.org/W2157458508', 'https://openalex.org/W2160756953', 'https://openalex.org/W2165054139', 'https://openalex.org/W2783142245', 'https://openalex.org/W4313305979'], 'related_works': ['https://openalex.org/W4317877637', 'https://openalex.org/W2902078213', 'https://openalex.org/W2781315531', 'https://openalex.org/W2417067056', 'https://openalex.org/W2114286636', 'https://openalex.org/W2050690016', 'https://openalex.org/W2027029136', 'https://openalex.org/W2009590415', 'https://openalex.org/W1997929376', 'https://openalex.org/W1982694172'], 'abstract_inverted_index': {'T-cell': [0, 36, 74, 118, 155, 161, 197, 235, 279, 316, 456, 570, 716, 910, 1888, 1922, 3381, 3555], 'migration': [1, 37, 156, 162, 198, 317, 330, 717, 950, 1525, 3594, 4033], 'is': [2, 38, 90, 151, 163, 199, 251, 312, 712, 905, 1160, 1170, 1329, 1334, 1597, 1723, 1782, 1894], 'a': [3, 67, 164, 228, 348, 562, 582, 875, 1123, 1275, 1301, 1518, 1598, 1678, 1689, 1836, 1882, 2105, 2190, 2219, 2228, 2287, 2335, 2345, 2711, 2883, 2948, 2958, 2969, 2976, 2983, 3112, 3262, 3363, 3527, 3566, 3679, 3731, 3928, 3937, 3941, 3950, 4002, 4010, 4035, 4074], 'complex': [4, 165], 'highly': [5, 166, 3958], 'coordinated': [6, 167, 725], 'process': [7, 99, 168, 260, 346], 'that': [8, 34, 88, 132, 149, 169, 195, 249, 293, 310, 373, 579, 1047, 1130, 1332, 1899, 2323, 2333, 2732, 3575, 3639, 3735, 3802, 3952], 'involves': [9, 170, 347, 718], 'cell': [10, 171, 573, 710, 796, 799, 869, 969, 1269, 1341, 1524, 1682, 1786, 1826, 2046, 2294, 2327, 2398, 2447, 2495, 3044, 3100, 3121, 3847, 4032, 4137], 'adhesion': [11, 172, 440, 552, 737, 3122, 3251, 3853, 4143], 'to': [12, 18, 61, 94, 138, 173, 179, 222, 255, 299, 381, 480, 566, 1065, 1241, 1257, 1267, 1271, 1725, 1730, 1745, 1828, 1901, 1908, 1955, 2121, 2201, 2253, 2321, 2458, 2469, 2473, 2519, 2569, 2617, 2735, 2975, 3049, 3160, 3336, 3377, 3428, 3445, 3493, 3503, 3580, 3599, 3753, 3810, 3854, 3925, 3940, 3956, 4022, 4144, 4201], 'the': [13, 19, 44, 95, 98, 174, 180, 205, 256, 259, 325, 334, 342, 386, 424, 483, 550, 697, 723, 728, 731, 786, 860, 864, 868, 871, 902, 975, 978, 992, 1034, 1039, 1054, 1058, 1105, 1112, 1171, 1265, 1268, 1304, 1513, 1603, 1739, 1825, 1902, 1949, 1956, 2163, 2211, 2240, 2246, 2291, 2309, 2385, 2446, 2452, 2459, 2558, 2563, 2570, 2585, 2607, 2666, 2676, 2843, 2863, 2866, 3024, 3050, 3075, 3091, 3106, 3161, 3214, 3243, 3256, 3270, 3325, 3337, 3399, 3413, 3473, 3494, 3622, 3718, 3781, 3789, 4108, 4157, 4194], 'high': [14, 175, 467, 2878, 3921], 'endothelial': [15, 176], 'venules': [16, 177], 'or': [17, 178, 488, 963, 2153, 2173, 2186, 2222, 2476, 2497, 2649, 3145, 3480, 3491, 3525, 3852, 3947, 4066, 4086, 4142], 'extracellular': [20, 181, 343], 'matrix': [21, 182], 'by': [22, 113, 183, 274, 960, 1133, 1254, 1311, 1733, 1785, 1896, 2451, 2511, 2523, 2720, 2818, 2875, 2900, 2968, 3038, 3090, 3104, 3187, 3254, 3329, 3362, 3384, 3559, 4193], 'surface': [23, 184, 1787, 2203], 'receptor/ligand': [24, 185, 3673], 'interactions,': [25, 186], 'cytoskeletal': [26, 187, 596, 707, 761], 'rearrangements,': [27, 188], 'and': [28, 54, 92, 124, 157, 189, 215, 253, 285, 318, 340, 378, 383, 445, 568, 571, 595, 709, 722, 730, 734, 762, 788, 803, 954, 995, 1003, 1006, 1012, 1041, 1051, 1072, 1107, 1117, 1136, 1239, 1244, 1344, 1608, 1692, 1791, 1841, 1848, 1904, 1916, 1975, 1979, 1999, 2028, 2058, 2095, 2100, 2177, 2231, 2301, 2304, 2340, 2343, 2396, 2509, 2614, 2663, 2718, 2789, 2846, 2873, 2914, 2922, 2993, 3072, 3194, 3242, 3656, 3667, 3677, 3759, 3923, 4037, 4076, 4112, 4223], 'phosphorylation-dependent': [29, 190], 'signaling': [30, 112, 159, 191, 273, 320, 703, 763, 804, 1697, 3507, 3640], 'cascades.': [31, 192], 'The': [32, 193, 1031, 1114, 1157, 1588, 1715, 1777, 1964, 2442, 2494, 2513, 2529, 2601, 2893, 3098, 3172, 3233, 3321, 4184], 'mechanism(s)': [33, 194], 'regulates': [35, 196], 'of': [39, 46, 65, 100, 103, 122, 127, 200, 207, 226, 261, 264, 283, 288, 324, 331, 350, 447, 584, 700, 736, 785, 794, 951, 965, 974, 977, 991, 999, 1033, 1044, 1053, 1061, 1109, 1119, 1125, 1162, 1167, 1274, 1277, 1303, 1307, 1605, 1718, 1741, 1780, 1921, 1948, 1958, 2115, 2119, 2257, 2290, 2293, 2311, 2317, 2348, 2378, 2445, 2464, 2636, 2896, 3070, 3085, 3156, 3163, 3269, 3324, 3334, 3341, 3355, 3389, 3421, 3475, 3511, 3535, 3563, 3595, 3614, 3624, 3660, 3720, 3748, 3771, 3780, 3788, 3793, 3798, 3823, 3835, 4012, 4014, 4026, 4044, 4053, 4110, 4114, 4126, 4156, 4166, 4186, 4196, 4230, 4237], 'considerable': [40, 201], 'relevance': [41, 202], 'for': [42, 83, 154, 203, 244, 315, 791, 948, 1521, 1884, 1919, 2239, 2375, 2506, 2526, 2550, 2595, 2654, 2671, 2799, 2858, 2910, 2916, 3012, 3017, 3093, 3177, 3203, 3227, 3578, 3606, 3756, 3765, 3960, 4016, 4056, 4096, 4151, 4159], 'understanding': [43, 204], 'pathogenesis': [45, 206], 'various': [47, 208], 'diseases,': [48, 209], 'such': [49, 210], 'as': [50, 211, 1300, 1594, 1677, 1688, 1924, 2060, 2135, 2262, 2402, 2478, 2674, 2782, 2926, 3126, 3275, 3349, 4001], 'chronic': [51, 212], 'inflammatory': [52, 213, 1308], 'diseases': [53, 214], 'cancer': [55, 216], 'metastasis.': [56, 217], 'This': [57, 218, 345, 3436, 3873, 3932], 'study': [58, 219, 1833], 'was': [59, 220, 1297, 1947, 2011, 2018, 2037, 2056, 2126, 2260, 2382, 2400, 2449, 2716, 2804, 2924, 2945, 2966, 3021, 3036, 3102, 3124, 3246, 3252, 3375, 3395, 3442, 3458, 3482, 3538, 3617, 3627, 3934, 3999, 4047, 4168, 4191], 'designed': [60, 221], 'identify': [62, 223], 'potential': [63, 224], 'involvement': [64, 225], 'STAT3,': [66, 227, 1842, 2474, 3721], 'latent': [68, 229, 1126], 'transcription': [69, 230, 1120, 1128, 1273], 'factor,': [70, 231], 'in': [71, 80, 142, 232, 241, 303, 478, 556, 587, 706, 727, 878, 909, 984, 1165, 1336, 1472, 1523, 1526, 1602, 1681, 1886, 1912, 2080, 2104, 2218, 2227, 2233, 2296, 2535, 2540, 2546, 2583, 2633, 2852, 2856, 2870, 3060, 3067, 3153, 3201, 3222, 3248, 3398, 3431, 3438, 3472, 3513, 3519, 3532, 3540, 3621, 3643, 3777, 3807, 3927, 4034, 4119, 4204], 'mediating': [72, 233], 'integrin-induced': [73, 234, 2123], 'migration.': [75, 236, 1889], 'Using': [76, 237, 2624], 'our': [77, 238, 2129], 'previously': [78, 239, 1925, 2062, 2136, 2264, 2404, 2480, 2927, 3128, 3277], 'characterized': [79, 240, 2131], 'vitro': [81, 242], 'model': [82, 243, 2133], 'lymphocyte': [84, 245, 376, 426, 435], 'migration,': [85, 246, 802], 'we': [86, 130, 247, 291, 1880, 3501, 3728], 'demonstrate': [87, 248, 3638], 'STAT3': [89, 111, 133, 150, 250, 272, 294, 311, 1169, 1262, 1296, 1333, 1470, 1522, 1844, 1885, 1893, 3394, 3410, 3422, 3439, 3455, 3512, 3536, 3564, 3625, 3650, 3661, 3738, 3836, 3926, 4179], 'activated': [91, 252, 1132, 1261, 1895], 'translocated': [93, 254, 3411], 'nucleus': [96, 257, 1270, 1903, 3414], 'during': [97, 258, 3629], 'active': [101, 262], 'motility': [102, 263, 911, 1923], 'Hut78': [104, 265, 2048, 2206, 2629, 3056, 3147, 3392, 3495, 3514, 3520, 3596, 3615, 3644, 3741, 3772, 3799, 3824, 3846, 4005, 4127, 4170, 4240], 'T-lymphoma': [105, 266, 2045], 'cells': [106, 267, 2077, 2207, 2322, 2332, 2372, 2630, 3057, 3148, 3152, 3173, 3184, 3215, 3234, 3461, 3496, 3521, 3597, 3616, 3645, 3669, 3742, 3773, 3800, 3809, 3813, 3825, 4006, 4027, 4065, 4067, 4090, 4111, 4121, 4128, 4158, 4171, 4241], 'triggered': [107, 268, 1310, 3670, 4080], 'via': [108, 120, 269, 281, 3406, 3488, 3522, 3588, 3671, 4081], 'LFA-1.': [109, 270], 'Blocking': [110, 271], 'multiple': [114, 275, 952], 'approaches': [115, 276, 4190], 'inhibited': [116, 277, 3831, 4030], 'LFA-1-induced': [117, 278, 1887, 3664, 3782, 3832, 4031, 4178, 4234], 'locomotion': [119, 280, 711], 'destabilization': [121, 282], 'microtubules': [123, 284], 'post-translational': [125, 286, 1067], 'modification': [126, 287], 'tubulin.': [128, 289], 'Here,': [129, 290, 1879], 'show': [131, 292, 4177], 'physically': [134, 295], 'interacts': [135, 296, 1845, 1905], 'with': [136, 297, 547, 987, 1008, 1846, 1906, 2169, 2180, 2197, 2298, 2471, 2502, 2562, 2577, 2589, 2646, 2665, 2815, 2957, 3074, 3082, 3140, 3192, 3196, 3212, 3218, 3240, 3649, 3745, 3774, 3816, 3826, 3920, 3936, 4009, 4028, 4069, 4083, 4092, 4102, 4129, 4162, 4173, 4244], 'stathmin': [137, 298, 1591, 1719, 1781, 1822, 1840, 1847, 1907], 'regulate': [139, 300, 1909], 'microtubule': [140, 301, 452, 979], 'dynamics': [141, 302, 1050, 1609, 1911], 'migrating': [143, 304, 477, 1913, 3610], 'T-cells.': [144, 305, 1914, 4238], 'These': [145, 306, 971], 'observations': [146, 307], 'strongly': [147, 308], 'indicate': [148, 309], 'critically': [152, 313], 'important': [153, 314, 790, 907, 1243], 'associated': [158, 319, 3648, 4115], 'events.': [160, 321], 'Efficient': [322], 'operation': [323], 'adaptive': [326], 'immune': [327], 'system': [328, 2611], 'requires': [329], 'T-lymphocytes': [332], 'from': [333, 549, 1264, 1727, 1960, 1983, 2006, 2012, 2019, 2033, 2039, 2794, 2805, 2842, 2848, 3751, 3805, 4020], 'vascular': [335], 'compartment': [336], 'across': [337, 385, 482], 'tissue': [338, 2155, 2642], 'barriers': [339], 'through': [341, 3641, 3882], 'matrix.': [344], 'series': [349], 'integrin': [351, 1010], 'ligand-receptor': [352], 'interactions': [353], '(1Hogg': [354, 491], 'N.': [355, 492, 534, 1283, 1489], 'Laschinger': [356, 493], 'M.': [357, 407, 494, 674, 1225, 1396, 1415, 1427, 1487, 1533, 1545, 1567, 1650, 1750, 2270, 2428, 3301, 3886, 4213], 'Giles': [358, 495], 'K.': [359, 496, 810, 830, 1077, 1423, 1479, 1481, 1541, 1565, 1573, 3132, 3890, 4208], 'McDowall': [360, 497, 527], 'A.': [361, 403, 411, 498, 513, 526, 528, 530, 601, 612, 636, 652, 672, 680, 740, 915, 928, 1198, 1369, 1500, 1700, 1805, 1930, 2066, 2141, 2266, 2274, 2932, 3685, 3698, 3971, 4212, 4215], 'J.': [362, 499, 516, 536, 604, 619, 743, 768, 808, 848, 887, 918, 1284, 1577, 1579, 1664, 1766, 1868, 2069, 2144, 2410, 2431, 2765, 2829, 2935, 3283, 3304, 3688, 3896, 3903, 3972, 4210], 'Cell': [363, 500, 812, 834, 849, 889, 1021, 1081, 1147, 1183, 1247, 1317, 1354, 1613, 1869, 1984, 2041, 2116, 2393, 2700, 2722, 3032, 3118, 3250], 'Sci.': [364, 501, 1497, 1703], '2003;': [365, 502, 836, 891, 1083, 3906], '116:': [366, 503], '4695-4705Crossref': [367, 504], 'PubMed': [368, 397, 417, 505, 540, 624, 644, 664, 749, 777, 822, 839, 854, 894, 940, 1026, 1086, 1099, 1152, 1188, 1217, 1234, 1291, 1322, 1359, 1388, 1405, 1437, 1464, 1504, 1555, 1583, 1623, 1638, 1657, 1670, 1710, 1759, 1772, 1812, 1874, 1942, 2280, 2364, 2437, 2489, 2772, 3137, 3310, 3710, 3914, 3981, 3992], 'Scopus': [369, 398, 418, 506, 541, 625, 645, 665, 692, 750, 823, 840, 855, 895, 941, 1027, 1087, 1153, 1189, 1218, 1235, 1292, 1323, 1360, 1389, 1406, 1438, 1465, 1505, 1556, 1584, 1624, 1639, 1658, 1671, 1711, 1760, 1773, 1813, 1875, 1943, 2281, 2438, 2490, 2773, 2835, 3311, 3711, 3915, 3993], '(244)': [370, 507], 'Google': [371, 400, 420, 508, 521, 543, 609, 627, 647, 667, 694, 752, 778, 825, 842, 857, 897, 923, 943, 1029, 1089, 1100, 1155, 1191, 1220, 1237, 1294, 1325, 1362, 1391, 1408, 1440, 1467, 1507, 1558, 1586, 1626, 1641, 1660, 1673, 1713, 1762, 1775, 1815, 1877, 1945, 2074, 2149, 2283, 2365, 2440, 2492, 2775, 2837, 2940, 3138, 3313, 3693, 3713, 3917, 3982, 3995], 'Scholar)': [372, 1946, 3139, 3314], 'initially': [374], 'retards': [375], 'flow': [377], 'ultimately': [379], 'leads': [380], 'arrest': [382], 'diapedesis': [384], 'endothelium': [387], '(2Springer': [388], 'T.A.': [389], 'Cell.': [390, 1208, 1379, 1430, 1548, 1653], '1994;': [391, 1431, 1549, 2832, 3975], '76:': [392], '301-314Abstract': [393], 'Full': [394, 687, 689, 817, 819, 1212, 1214, 1383, 1385, 1434, 1552, 1618, 1620, 1707, 3909, 3911, 3978], 'Text': [395, 688, 690, 818, 820, 1213, 1215, 1384, 1386, 1435, 1553, 1619, 1621, 1708, 3910, 3912, 3979], 'PDF': [396, 691, 821, 1216, 1387, 1436, 1554, 1622, 1709, 3913, 3980], '(6400)': [399], 'Scholar,': [401, 509, 522, 610, 628, 648, 668, 826, 843, 924, 1090, 1192, 1221, 1363, 1392, 1409, 1441, 1559, 1627, 1642, 1661, 1763, 3694, 3983], '3Fanning': [402], 'Volkov': [404, 617, 631, 2267, 2429, 3302], 'Y.': [405, 511, 599, 618, 632, 650, 670, 913, 926, 1413, 1531, 1569, 1928, 2064, 2139, 2268, 2430, 2930, 3303, 3683, 3696, 4224], 'Freely': [406, 2269], 'Kelleher': [408, 514, 602, 613, 633, 657, 681, 916, 933, 1935, 2067, 2142, 2271, 2417, 2933, 3290, 3686, 3703], 'D.': [409, 515, 532, 603, 614, 634, 658, 682, 766, 917, 934, 1227, 1398, 1752, 1936, 2068, 2143, 2272, 2418, 2934, 3291, 3687, 3704, 3965, 4221], 'Long': [410, 512, 600, 635, 651, 671, 914, 927, 1929, 2065, 2140, 2273, 2931, 3684, 3697], 'Int.': [412, 886, 1093, 2275, 2358, 2764], 'Immunol.': [413, 517, 605, 620, 660, 773, 919, 936, 1230, 1401, 1755, 1938, 2070, 2145, 2276, 2936, 3689, 3706], '2005;': [414, 641, 684, 814, 1288, 1461, 1809, 2277], '17:': [415, 2278], '449-458Crossref': [416, 2279], '(30)': [419, 2282], 'Scholar).': [421, 544, 695, 753, 779, 858, 898, 944, 1030, 1156, 1295, 1326, 1468, 1587, 1674, 1714, 1776, 1816, 1878, 2075, 2150, 2284, 2366, 2441, 2493, 2838, 2941, 3714, 3996], 'T-cells': [422, 589, 2120], 'utilize': [423], 'integrin,': [425], 'function-associated': [427, 436], 'antigen-1': [428], '(LFA-1),': [429], '3The': [430], 'abbreviations': [431], 'used': [432, 1918, 2057, 3729, 4000], 'are:': [433], 'LFA-1,': [434], 'antigen-1;': [437], 'ICAM,': [438], 'intercellular': [439, 551], 'molecule;': [441], 'STAT,': [442], 'signal': [443, 1115], 'transducers': [444, 1116], 'activators': [446, 1118], 'transcription;': [448], 'MT,': [449], 'microtubule;': [450], 'MTOC,': [451], 'organizing': [453, 980], 'center;': [454], 'TCR,': [455], 'receptor;': [457], 'Fmoc,': [458], '9-fluorenylmethoxycarbonyl;': [459], 'DI,': [460], 'deformation': [461, 2349], 'index;': [462], 'PBS,': [463, 3213, 3241], 'phosphate-buffered': [464, 2547], 'saline;': [465], 'HCA,': [466], 'content': [468, 2444], 'analysis;': [469], 'Antp,': [470], 'Antennapedia': [471, 2911, 3948], 'peptide;': [472], 'pY-pept,': [473], 'STAT3-inhibitory': [474, 2917, 4231], 'peptide.': [475, 4004], 'when': [476, 3460, 3812, 4079], 'response': [479, 1309], 'chemoattractants': [481], 'vasculature': [484], 'into': [485, 901, 2210, 2640, 3412], 'lymph': [486], 'nodes': [487], 'inflamed': [489], 'tissues': [490], '4Volkov': [510], '1998;': [518, 606, 920, 1096, 2071, 2146, 2361, 2937, 3690], '161:': [519, 607, 921, 2072, 2147, 2938, 3691], '6487-6495PubMed': [520, 608, 922, 2073, 2148, 2939, 3692], '5Stanley': [523], 'P.': [524, 1629, 1631, 1646, 1801, 2412, 3285, 3888, 3898, 3987], 'Smith': [525], 'Nicol': [529], 'Zicha': [531], 'Hogg': [533], 'EMBO': [535, 1578], '2008;': [537, 1654, 2434, 3307], '27:': [538], '62-75Crossref': [539], '(101)': [542], 'By': [545, 1817], 'engagement': [546], 'ligands': [548], 'molecule': [553], 'group': [554], '(ICAMs),': [555], 'particular': [557, 2164, 2247, 2660], 'ICAM-1,': [558, 2648, 3526], 'LFA-1': [559, 580, 1891, 1959, 3385, 3404, 3485, 3506, 3517, 3612, 3642, 3672, 4082], 'also': [560, 1685, 3830], 'provides': [561, 863, 2286], 'strong': [563], 'adhesive': [564], 'force': [565, 866], 'promote': [567], 'stabilize': [569], 'antigen-presenting': [572], 'conjugate': [574], 'formation.': [575], 'We': [576, 3860], 'have': [577, 1242, 2351], 'demonstrated': [578, 3801], 'transduces': [581], 'variety': [583], 'transmembrane': [585], 'signals': [586], 'crawling': [588], 'involving': [590], 'protein': [591, 1001, 1600, 1691, 1694, 2443, 2454, 3626], 'kinase': [592, 1789], 'C': [593], 'activation': [594, 2673, 2715, 3456, 3474, 3558, 3569], 'rearrangement': [597], '(4Volkov': [598, 912, 2063, 2138, 2929, 3682], '6Long': [611], 'Lynch': [615], 'S.': [616, 630, 654, 828, 930, 1075, 1194, 1365, 1411, 1419, 1455, 1493, 1499, 1529, 1537, 1561, 1563, 1575, 1648, 1932, 2420, 3293, 3700], '2001;': [621, 661, 937, 1319, 1939, 3707, 3989], '167:': [622], '636-640Crossref': [623], '(36)': [626], '7Freely': [629], 'Biochem.': [637, 888, 1702], 'Biophys.': [638], 'Res.': [639, 1287, 2768], 'Commun.': [640], '334:': [642], '619-630Crossref': [643], '(26)': [646], '8Volkov': [649, 925, 3695], 'McGrath': [653, 929, 1931, 3699], 'Eidhin': [655, 931, 1933, 3701], 'D.N.': [656, 932, 1934, 3702], 'Nat.': [659, 831, 935, 1078, 1144, 1180, 1228, 1351, 1399, 1753, 1937, 3705], '2:': [662, 938, 1210, 1381, 1940, 3708], '508-514Crossref': [663, 939, 1941, 3709], '(128)': [666, 942, 1944, 3712], '9Volkov': [669], 'Freeley': [673], 'Golden-Mason': [675], 'L.': [676, 1447, 1451], "O'Farrelly": [677], 'C.': [678, 1196, 1367, 1795, 4219], 'Murphy': [679], 'Gastroenterology.': [683], '130:': [685], '482-492Abstract': [686], '(12)': [693], 'However,': [696, 1327, 3585, 4107], 'exact': [698], 'sequence': [699, 3944], 'downstream': [701], 'integrin-mediated': [702], 'events': [704], 'resulting': [705], 'rearrangements': [708], 'not': [713, 3592, 3603, 4123, 4176], 'fully': [714], 'understood.': [715], 'cross-talk': [719], 'between': [720, 1839], 'integrins': [721], 'cytoskeleton,': [724, 729], 'changes': [726, 983, 3647], 'controlled': [732], 'formation': [733, 4113], 'dispersal': [735], 'sites': [738], '(10Kupfer': [739], 'Singer': [741], 'S.J.': [742], 'Exp.': [744], 'Med.': [745, 2433, 3306], '1989;': [746], '170:': [747], '1697-1713Crossref': [748], '(141)': [751], 'Motile': [754], 'lymphocytes': [755], 'develop': [756, 3678], 'trailing': [757, 2341], 'extensions,': [758], 'which': [759, 961, 1102, 1168, 1737, 2803], 'contain': [760], 'elements': [764], '(11Hauzenberger': [765], 'Klominek': [767], 'Sundqvist': [769], 'K.G.': [770], 'Crit.': [771], 'Rev.': [772, 832, 1079, 1094, 1145, 1181, 1229, 1352, 1400, 1754, 2359], '1995;': [774], '15:': [775, 815], '285-316Crossref': [776], 'Microtubules': [780], '(MTs)': [781], 'are': [782, 789, 946, 956, 1063, 1122, 1131, 2319, 3347], 'essential': [783], 'components': [784], 'cytoskeleton': [787, 862, 1036], 'many': [792, 1134], 'aspects': [793], 'mammalian': [795], 'responses,': [797], 'including': [798, 1069, 1340, 3653], 'division,': [800], 'growth,': [801], '(12Watanabe': [805], 'T.': [806, 1200, 1371, 1421, 1425, 1429, 1485, 1491, 1539, 1543, 1547, 1863], 'Noritake': [807], 'Kaibuchi': [809], 'Trends': [811, 1612, 1701], 'Biol.': [813, 835, 850, 890, 1022, 1082, 1148, 1184, 1318, 1355, 1614, 1652, 1666, 1768, 1870, 3904, 3973], '76-83Abstract': [816], '(249)': [824], '13Westermann': [827], 'Weber': [829, 1076], 'Mol.': [833, 1080, 1146, 1182, 1353, 1651, 2432, 3305], '4:': [837, 1084], '938-947Crossref': [838, 1085], '(574)': [841, 1088], '14Gundersen': [844], 'G.G.': [845], 'Bulinski': [846], 'J.C.': [847], '1986;': [851], '102:': [852], '1118-1126Crossref': [853], '(87)': [856], 'Whereas': [859], 'actin': [861], 'driving': [865], 'at': [867, 2108, 2236, 2553, 2574, 2598, 2691, 3108, 3180, 3206, 3230, 3258, 3572, 4049, 4057], 'front,': [870], 'MT': [872, 899, 985, 993, 1035, 1606, 1721, 1819, 1851, 1910, 3018], 'network': [873], 'assumes': [874], 'regulatory': [876], 'function': [877], 'coordinating': [879], 'rear': [880], 'retraction': [881, 900], '(15Wehrle-Haller': [882], 'B.': [883, 1445, 1449], 'Imhof': [884], 'H.A.': [885], '35:': [892, 2770], '39-50Crossref': [893], '(171)': [896, 1640], 'cellular': [903], 'uropod': [904], 'an': [906, 2696, 2744, 3094, 3164, 3331, 3426], 'step': [908], 'MTs': [945, 966, 1110], 'necessary': [947], 'directed': [949], 'cells,': [953, 3393], 'there': [955], 'several': [957, 1045, 1337], 'possible': [958], 'mechanisms': [959], 'disruption': [962], 'interference': [964, 1007], 'could': [967], 'block': [968, 1060], 'motility.': [970], 'include': [972], 'impairment': [973], 'repositioning': [976], 'center': [981], '(MTOC),': [982], 'interaction': [986, 3674], 'focal': [988], 'adhesions,': [989], 'inhibition': [990, 998, 3779], 'polymerization': [994, 1746], 'depolymerization': [996, 1852], 'cycle,': [997], 'intracellular': [1000, 1696], 'trafficking': [1002, 2727], 'vesicle': [1004], 'transport,': [1005], 'MT-mediated': [1009], 'clustering': [1011], 'increased': [1013], 'avidity': [1014], '(16Waterman-Storer': [1015], 'C.M.': [1016], 'Salmon': [1017], 'E.D.': [1018], 'Curr.': [1019, 1315], 'Opin.': [1020, 1316], '1999;': [1023, 1580], '11:': [1024], '61-67Crossref': [1025], '(219)': [1028], 'reorganization': [1032], 'depends': [1037], 'on': [1038, 1720, 2162, 2245, 2659, 2743, 2882, 2947, 3464, 3609, 3761, 3795, 3845, 4136, 4233], 'global': [1040], 'local': [1042], 'activity': [1043, 1779, 1853], 'proteins': [1046, 2515], 'affect': [1048, 3844], 'nucleation': [1049], 'arrangement': [1052], 'filament': [1055], 'systems.': [1056], 'Tubulins,': [1057], 'building': [1059], 'MTs,': [1062], 'subject': [1064], 'specific': [1066], 'modifications,': [1068], 'acetylation,': [1070], 'detyrosination,': [1071], 'tyrosination': [1073], '(13Westermann': [1074], '17Luduena': [1091], 'R.F.': [1092, 2357], 'Cytol.': [1095, 2360], '178:': [1097, 2362], '207-275Crossref': [1098, 2363], 'Scholar),': [1101, 1238, 1508, 2776, 3918], 'potentially': [1103], 'modulate': [1104], 'functions': [1106], 'localization': [1108], 'within': [1111, 1695, 3415], 'cell.': [1113], '(STATs)': [1121], 'family': [1124, 1159, 1252], 'cytoplasmic': [1127, 2736, 3409], 'factors': [1129, 1138], 'cytokines': [1135], 'growth': [1137, 1722], '(18Levy': [1139, 1175, 1346], 'D.E.': [1140, 1176, 1347], 'Darnell': [1141, 1177, 1348], 'Jr.,': [1142, 1178, 1349], 'J.E.': [1143, 1179, 1350], '2002;': [1149, 1185, 1209, 1356, 1380], '3:': [1150, 1186, 1357], '651-662Crossref': [1151, 1187, 1358], '(2501)': [1154, 1190, 1361], 'STAT': [1158, 1251, 2621, 2672, 2714, 3477], 'composed': [1161], 'seven': [1163], 'members': [1164, 1253], 'mammals,': [1166], 'most': [1172], 'pleiotropic': [1173], 'member': [1174], '19Yamashita': [1193, 1364], 'Miyagi': [1195, 1366], 'Carmany-Rampey': [1197, 1368], 'Shimizu': [1199, 1370], 'Fujii': [1201, 1372], 'R.': [1202, 1373, 1453, 1457], 'Schier': [1203, 1374], 'A.F.': [1204, 1206, 1375, 1377], 'Hirano': [1205, 1376], 'Dev.': [1207, 1378], '363-375Abstract': [1211, 1382], '(154)': [1219, 1390], '20Yu': [1222, 1393], 'H.': [1223, 1394, 1571, 1748], 'Kortylewski': [1224, 1395, 1749], 'Pardoll': [1226, 1397, 1751], '2007;': [1231, 1402, 1667, 1756, 1769], '7:': [1232, 1403, 1757], '41-51Crossref': [1233, 1404, 1758], '(1464)': [1236, 1407, 1761], 'appears': [1240], 'unique': [1245], 'functions.': [1246], 'stimulation': [1248], 'can': [1249], 'activate': [1250], 'tyrosine': [1255, 1897, 3509, 3533, 3561, 3657, 3739, 3833, 4180], 'phosphorylation': [1256, 1898, 3510, 3534, 3562, 3834, 4181], 'induce': [1258, 3593, 4202], 'their': [1259], 'dimerization;': [1260], 'translocates': [1263, 1900], 'cytosol': [1266], 'mediate': [1272], 'number': [1276], 'STAT3-responsive': [1278], 'genes': [1279], '(21Brierley': [1280], 'M.M.': [1281], 'Fish': [1282], 'Inteferon': [1285], 'Cytokine': [1286], '25:': [1289], '733-744Crossref': [1290], '(164)': [1293], 'originally': [1298], 'identified': [1299, 1676, 3881], 'mediator': [1302], 'acute': [1305], 'phase': [1306], 'interleukin-6': [1312], '(22Ihle': [1313], 'J.N.': [1314], '13:': [1320], '211-217Crossref': [1321], '(593)': [1324], 'it': [1328, 1684], 'now': [1330], 'known': [1331, 1593], 'implicated': [1335], 'biological': [1338], 'processes,': [1339], 'proliferation,': [1342, 1683], 'differentiation,': [1343], 'survival': [1345, 3848, 4138], '23Akira': [1410], 'Nishio': [1412, 1530], 'Inoue': [1414, 1532], 'Wang': [1416, 1534], 'X.J.': [1417, 1535], 'Wei': [1418, 1536], 'Matsusaka': [1420, 1538], 'Yoshida': [1422, 1488, 1540], 'Sudo': [1424, 1542], 'Naruto': [1426, 1544], 'Kishimoto': [1428, 1490, 1546], '77:': [1432, 1550], '63-71Abstract': [1433, 1551], '(871)': [1439, 1557], '24Dauer': [1442], 'D.J.': [1443, 3985], 'Ferraro': [1444], 'Song': [1446], 'Yu': [1448], 'Mora': [1450], 'Buettner': [1452], 'Enkemann': [1454], 'Jove': [1456], 'Haura': [1458], 'E.B.': [1459], 'Oncogene.': [1460], '24:': [1462], '3397-3408Crossref': [1463], '(315)': [1466], 'Although': [1469], 'knock-out': [1471], 'mice': [1473], 'caused': [1474], 'early': [1475], 'embryonic': [1476], 'lethality': [1477], '(25Takeda': [1478], 'Noguchi': [1480], 'Shi': [1482], 'W.': [1483], 'Tanaka': [1484], 'Matsumoto': [1486], 'Akira': [1492, 1574], 'Proc.': [1494], 'Natl.': [1495], 'Acad.': [1496], 'U.': [1498], '1997;': [1501], '94:': [1502], '3801-3804Crossref': [1503], '(1100)': [1506], 'conditional': [1509], 'gene': [1510], 'targeting': [1511], 'using': [1512, 2128, 2384, 2606, 2695, 2710, 2725, 2777, 2982, 2995, 3023, 3111, 3261, 3315, 3864], 'Cre-loxP': [1514], 'strategy': [1515], 'has': [1516, 1834, 3953], 'revealed': [1517], 'critical': [1519], 'role': [1520, 1883, 3719], 'keratinocytes': [1527], '(23Akira': [1528], '26Sano': [1560], 'Itami': [1562], 'Takeda': [1564, 1576], 'Tarutani': [1566], 'Yamaguchi': [1568], 'Miura': [1570], 'Yoshikawa': [1572], '18:': [1581], '4657-4668Crossref': [1582], '(434)': [1585], '18-kDa': [1589], 'phosphoprotein': [1590], '(also': [1592], 'oncoprotein': [1595], '18)': [1596], 'tubulin-binding': [1599], 'involved': [1601], 'control': [1604, 2191, 3339, 4003], 'assembly': [1607], '(27Andersen': [1610], 'S.S.': [1611], '2000;': [1615, 3134], '10:': [1616], '261-267Abstract': [1617], '(181)': [1625], '28Niethammer': [1628], 'Bastiaens': [1630], 'Karsenti': [1632], 'E.': [1633, 1803, 2408, 3281, 3892], 'Science.': [1634], '2004;': [1635], '303:': [1636], '1862-1866Crossref': [1637], '29Sellin': [1643], 'M.E.': [1644], 'Holmfeldt': [1645], 'Stenmark': [1647], 'Gullberg': [1649], '19:': [1655], '2897-2906Crossref': [1656], '(24)': [1659], '30Steinmetz': [1662, 1764], 'M.O.': [1663, 1765], 'Struct.': [1665, 1767], '158:': [1668, 1770], '137-147Crossref': [1669, 1771], '(73)': [1672, 1774], 'Originally': [1675], 'key': [1679], 'factor': [1680], 'plays': [1686], 'roles': [1687], 'relay': [1690], 'integrating': [1693], 'networks': [1698], '(31Sobel': [1699], '1991;': [1704], '16:': [1705], '301-305Abstract': [1706], '(250)': [1712], 'inhibitory': [1716, 3723, 3791, 3867], 'effect': [1717, 3792, 4135], 'believed': [1724], 'derive': [1726], 'its': [1728, 1850], 'ability': [1729, 2118], 'sequester': [1731], 'tubulin': [1732, 1735, 1993, 1997], 'binding': [1734], 'dimers,': [1736], 'decreases': [1738], 'concentration': [1740, 4052, 4165], 'free': [1742], 'heterodimers': [1743], 'available': [1744], '(20Yu': [1747], 'MT-destabilizing': [1778], 'turned': [1783], 'off': [1784], 'receptor': [1788, 3556], 'cascades': [1790], 'cyclin-dependent': [1792], 'kinases': [1793], '(32Giampietro': [1794], 'Luzzati': [1796], 'F.': [1797, 3130, 3900], 'Gambarotta': [1798], 'G.': [1799, 1861, 2422, 3295, 3969], 'Giacobini': [1800], 'Boda': [1802], 'Fasolo': [1804], 'Perroteau': [1806], 'I.': [1807], 'Endocrinology.': [1808], '146:': [1810], '1825-1834Crossref': [1811], '(32)': [1814], 'changing': [1818], 'polymerization/depolymerization': [1820], 'dynamics,': [1821], 'may': [1823], 'help': [1824], 'react': [1827], 'external': [1829], 'stimuli.': [1830], 'A': [1831, 3453], 'recent': [1832], 'suggested': [1835], 'functional': [1837, 3651], 'link': [1838], 'whereby': [1843], 'antagonizes': [1849], '(33Ng': [1854], 'D.C.H.': [1855], 'Lin': [1856], 'B.H.': [1857], 'Lim': [1858], 'C.P.': [1859], 'Huang': [1860], 'Zhang': [1862], 'Poli': [1864], 'V.': [1865], 'Cao': [1866], 'X.': [1867], '2006;': [1871, 2486], '172:': [1872], '245-257Crossref': [1873], '(220)': [1876], 'report': [1881], 'Upon': [1890], 'cross-linking,': [1892], 'Antibodies': [1915], 'Reagents—Antibody': [1917], 'induction': [1920], 'described': [1926, 2061, 2137, 2263, 2403, 2479, 2928, 3127, 3170, 3276], '(8Volkov': [1927], 'motility-inducing': [1950, 2183], 'clone': [1951], 'SPVL7': [1952], '(monoclonal': [1953], 'antibody': [1954, 2027, 2185], 'α-chain': [1957], 'Monosan,': [1961], 'Sanbio,': [1962], 'Uden,': [1963], 'Netherlands).': [1965], 'Rabbit': [1966], 'monoclonal': [1967, 1990, 2182], 'anti-STAT3,': [1968], 'anti-phospho-STAT3': [1969], '(Tyr705),': [1970], 'anti-stathmin,': [1971], 'anti-phosphostathmin(Ser16),': [1972], 'anti-glyceraldehyde-3-phosphate': [1973], 'dehydrogenase,': [1974], 'horseradish': [1976, 2591], 'peroxidase-conjugated': [1977, 2592], 'anti-rabbit': [1978], 'anti-mouse': [1980, 2009, 2026, 2171], 'antibodies': [1981, 2004, 2472, 2566, 2594], 'were': [1982, 2005, 2032, 2078, 2167, 2195, 2208, 2324, 2373, 2467, 2500, 2516, 2533, 2560, 2587, 2604, 2638, 2652, 2684, 2708, 2741, 2792, 2840, 2868, 2898, 2991, 3010, 3058, 3079, 3158, 3174, 3185, 3216, 3235, 3273, 3327, 3360, 3462, 3725, 3743, 3814, 4007, 4099, 4242], 'Signaling': [1985], 'Technology': [1986], '(Danvers,': [1987], 'MA).': [1988], 'Mouse': [1989], 'anti-α-tubulin,': [1991], 'anti-acetylated': [1992], '(clone': [1994], '6-11B-1),': [1995], 'anti-tyrosinated': [1996], '(TUB-1A2),': [1998], 'goat': [2000, 2170], 'anti-human': [2001, 2175], 'IgG': [2002, 2010, 2172], '(Fc-specific)': [2003], 'Sigma.': [2007], 'Goat': [2008], 'Dako': [2013], 'A/S': [2014], '(Denmark).': [2015], 'Human': [2016], 'rICAM-1': [2017], 'R&D': [2020], 'Systems': [2021], '(Minneapolis,': [2022], 'MN).': [2023], 'Alexa': [2024, 2029], 'fluor-488-conjugated': [2025], 'fluor-546': [2030], 'Phalloidin': [2031], 'Invitrogen.': [2034], 'Cell-permeable': [2035], 'AG490': [2036, 3749, 3775, 3794, 3819, 3829, 3839], 'obtained': [2038], 'Calbiochem.': [2040], 'Culture—The': [2042], 'human': [2043, 2187], 'cutaneous': [2044], 'line': [2047, 3546], '(American': [2049], 'Type': [2050], 'Culture': [2051], 'Collection': [2052], '(ATCC),': [2053], 'Manassas,': [2054], 'VA)': [2055], 'cultured': [2059, 2079], 'Briefly,': [2076, 2151, 3143], 'RPMI': [2081], '1640': [2082], 'medium': [2083, 3071], '(Invitrogen)': [2084], 'containing': [2085, 2111, 2690], '10%': [2086], '(v/v)': [2087, 2543], 'heat-inactivated': [2088], 'fetal': [2089], 'bovine': [2090], 'serum,': [2091], '2': [2092], 'mm': [2093], 'l-glutamine,': [2094], 'antibiotics': [2096], '(penicillin': [2097], '(100': [2098, 2102], 'IU/ml)': [2099], 'streptomycin': [2101], 'μg/ml))': [2103], 'humidified': [2106], 'chamber': [2107], '37': [2109, 2237, 3181], '°C': [2110, 2238, 2576], '5%': [2112, 2234, 2536], 'CO2.': [2113], 'Induction': [2114], 'Motility—The': [2117], 'display': [2122, 2334], 'locomotory': [2124, 2313, 4235], 'behavior': [2125], 'determined': [2127, 2450, 3328], 'well': [2130], 'migration-triggering': [2132], 'system,': [2134], '6-': [2152], '96-well': [2154, 2229, 2641, 3061, 3166, 3763], 'culture': [2156, 2643], 'plates': [2157, 2644, 3764, 3856, 4146], '(flat': [2158], 'bottom;': [2159], 'Nunc™),': [2160], 'depending': [2161, 2244, 2658], 'assay': [2165, 2455, 3046, 3123], 'type,': [2166], 'precoated': [2168, 2645], 'mouse': [2174], 'Fc': [2176], 'subsequently': [2178, 3736], 'incubated': [2179, 2232, 2561, 2588, 2653, 3081, 3176, 3463, 3760], 'cross-linking': [2181, 3405, 3486, 3518, 3613], 'anti-LFA-1': [2184, 3490, 3524], 'rICAM-1.': [2188], 'As': [2189], '(resting': [2192], 'cells),': [2193], 'wells': [2194, 2213, 3162], 'coated': [2196, 2212], 'poly-l-lysine': [2198], '(cells': [2199], 'adhered': [2200], 'this': [2202], 'without': [2204], 'activation).': [2205], 'loaded': [2209], '(60': [2214], '×': [2215, 2224, 2889, 3064, 3150], '104': [2216, 2225, 3065, 3151], 'cells/well': [2217, 2226, 2632], '6-well': [2220], 'plate': [2221, 3168], '1.0': [2223, 3335], 'plate)': [2230], 'CO2': [2235], 'indicated': [2241, 2564, 3076], 'time': [2242, 2656, 3631], 'periods,': [2243, 2657], 'experiments.': [2248], 'Deformation': [2249], 'Index': [2250], '(DI)—In': [2251], 'order': [2252], 'quantify': [2254], 'migratory': [2255], 'phenotype': [2256, 2310, 2337, 3681, 3784, 3797, 4046, 4236], 'T-cells,': [2258, 3611], 'DI': [2259, 2285, 2353, 3803, 4084, 4103], 'calculated': [2261, 3103, 3361], '(3Fanning': [2265], 'stronger': [2288], 'measure': [2289], 'degree': [2292, 2347], 'polarization': [2295], 'comparison': [2297, 3354], 'elongation': [2299], 'index': [2300], 'circularity': [2302], 'alone': [2303, 3998], 'therefore': [2305, 2344], 'more': [2306], 'accurately': [2307], 'reflects': [2308], 'polarized': [2312, 2336, 4075], 'cells.': [2314, 3515, 4206], 'Typically,': [2315], 'values': [2316, 2354, 3323, 3359], '1-3': [2318], 'assigned': [2320], 'nonmigratory': [2325], '(i.e.': [2326], 'shape': [2328], 'nearing': [2329], 'circular).': [2330], 'Those': [2331], '(cell': [2338], 'body': [2339], 'uropod)': [2342], 'higher': [2346, 2352], 'will': [2350], '(>5)': [2355], '(17Luduena': [2356], 'On': [2367], 'average,': [2368], '>40': [2369], 'randomly': [2370, 2687], 'chosen': [2371], 'scored': [2374], 'each': [2376, 3013, 3342], 'set': [2377], 'conditions.': [2379], 'Semiautomated': [2380, 3015], 'analysis': [2381, 2728, 3016], 'performed': [2383, 2401, 2925, 2946, 2967, 3022, 3125, 3274], 'Scion': [2386], 'Image': [2387, 3027], 'software': [2388, 2724, 3001, 3029, 3317], '(Scion': [2389], 'Corp.,': [2390], 'Frederick,': [2391], 'MD).': [2392], 'Lysis,': [2394], 'Immunoprecipitation,': [2395], 'Immunoblotting—The': [2397], 'lysis': [2399], '(34Verma': [2405, 3278], 'N.K.': [2406, 2482, 3279], 'Dempsey': [2407, 3280], 'Conroy': [2409, 3282], 'Olwell': [2411, 3284], 'McElligott': [2413, 3286], 'A.M.': [2414, 2416, 3287, 3289], 'Davies': [2415, 3288], 'Butini': [2419, 3292], 'Campiani': [2421, 3294], 'Williams': [2423, 3296], 'D.C.': [2424, 3297], 'Zisterer': [2425, 3298], 'D.M.': [2426, 3299], 'Lawler': [2427, 3300], '86:': [2435, 3308], '457-469Crossref': [2436, 3309], '(33)': [2439, 3312], 'lysates': [2448, 2466, 2496], 'Bio-Rad': [2453], 'kit': [2456, 2670, 3047], 'according': [2457, 2568, 3048], "manufacturer's": [2460, 2571, 2677, 3051], 'instructions.': [2461], 'Equal': [2462], 'amounts': [2463], 'precleared': [2465], 'subjected': [2468], 'immunoprecipitation': [2470], 'α-tubulin,': [2475], 'stathmin,': [2477], '(35Verma': [2481], 'Dey': [2483], 'C.S.': [2484], 'Diabetologia.': [2485], '49:': [2487], '1656-1660Crossref': [2488], '(16)': [2491], 'immunoprecipitated': [2498], 'samples': [2499, 3326, 3340], 'boiled': [2501], 'Laemmli': [2503], 'sample': [2504], 'buffer': [2505], '5': [2507], 'min': [2508, 3205, 3229, 3417, 3433, 3450, 3550, 3574], 'resolved': [2510], 'SDS-PAGE.': [2512], 'separated': [2514], 'electrophoretically': [2517], 'transferred': [2518], 'polyvinylidene': [2520, 2530], 'fluoride': [2521, 2531], 'membranes': [2522, 2532, 2586], 'semidry': [2524], 'blotting': [2525], '1': [2527, 2551, 2596, 3178, 3752, 3757, 4021], 'h.': [2528, 2860, 3097, 4024], 'blocked': [2534], 'nonfat': [2537], 'dry': [2538], 'milk': [2539], 'PBST': [2541], '(0.1%': [2542], 'Tween': [2544], '20': [2545, 3006, 3083], 'saline': [2548], '(PBS))': [2549], 'h': [2552, 2597, 3179, 3582, 3601, 3758, 3767, 4060, 4098, 4161], 'room': [2554, 2599, 3207, 3231], 'temperature.': [2555, 2600, 3208, 3232], 'After': [2556, 2580, 2861, 3209], 'washing,': [2557], 'blots': [2559, 3272], 'primary': [2565], '(diluted': [2567], 'instructions)': [2572], 'overnight': [2573], '4': [2575, 2859, 3096, 3581, 3600, 3766, 4059, 4097, 4160], 'gentle': [2578, 3188], 'rocking.': [2579], 'three': [2581, 3190], 'washes': [2582, 3211], 'PBST,': [2584], 'appropriate': [2590], 'secondary': [2593], 'immunoreactive': [2602], 'bands': [2603], 'visualized': [2605], 'enhanced': [2608], 'chemiluminescence': [2609], 'detection': [2610], '(Amersham': [2612], 'Biosciences)': [2613], 'subsequent': [2615], 'exposure': [2616], 'Kodak': [2618], 'light-sensitive': [2619], 'film.': [2620], 'Activation': [2622, 3388], 'Assay': [2623], 'High': [2625], 'Content': [2626], 'Analysis': [2627], '(HCA)—Serum-starved': [2628], '(10,000': [2631], '100': [2634, 2961, 3068, 3154], 'μl': [2635, 3069, 3084, 3155], 'medium)': [2637, 3157], 'seeded': [2639], 'anti-LFA-1,': [2647, 3408], 'poly-l-lysine.': [2650], 'Cells': [2651, 3078], 'different': [2655, 3007, 3568, 3746, 4245], 'experiments,': [2661], 'fixed,': [2662], 'stained': [2664, 3217], 'Cellomics®': [2667], 'HCS': [2668], 'reagent': [2669], 'per': [2675], 'instructions': [2678, 3052], '(Thermo': [2679], 'Fisher': [2680], 'Scientific': [2681], 'Inc.).': [2682], 'Plates': [2683], 'scanned': [2685], '(three': [2686], 'selected': [2688], 'fields/well': [2689], 'least': [2692, 3005, 4058], '300': [2693], 'cells)': [2694], 'automated': [2697], 'microscope': [2698, 2952], '(IN': [2699], 'Analyzer': [2701], '1000': [2702], 'HCA': [2703], 'platform;': [2704], 'GE': [2705], 'Healthcare).': [2706], 'Images': [2707, 2990], 'acquired': [2709, 2992], '×20': [2712], 'objective.': [2713], 'measured': [2717, 3037], 'analyzed': [2719], 'IN': [2721], 'Investigator': [2723], 'nuclear': [2726, 2734, 3423, 3440, 3654], 'module': [2729, 2981], '(GE': [2730], 'Healthcare)': [2731], 'quantifies': [2733], 'fluorescence': [2737], 'intensity.': [2738], 'Peptide': [2739], 'Synthesis—Peptides': [2740], 'synthesized': [2742], 'Applied': [2745], 'Biosystems': [2746], '(model': [2747], '433A)': [2748], 'peptide': [2749, 2912, 2918, 3868, 3933, 3943, 4071, 4232], 'synthesizer': [2750], '(Foster': [2751], 'City,': [2752], 'CA)': [2753], 'following': [2754, 3484], 'standard': [2755], 'Fmoc': [2756], 'amino': [2757, 2787], 'acid': [2758], 'chemistry': [2759, 3884], '(36Fields': [2760], 'G.B.': [2761], 'Noble': [2762], 'R.L.': [2763], 'Pept.': [2766], 'Protein': [2767], '1990;': [2769], '161-241Crossref': [2771], '(2333)': [2774], 'O-(benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium': [2778], 'hexa-fluorophosphate': [2779], '1-hydroxybenzotriazole': [2780], 'diisopropylethylamine': [2781], 'coupling': [2783, 2790], 'reagents.': [2784], 'All': [2785], 'Fmoc-protected': [2786, 2800], 'acids': [2788], 'reagents': [2791], 'purchased': [2793], 'Novabiochem': [2795], '(Darmstadt,': [2796], 'Germany)': [2797], 'except': [2798], 'phosphotyrosine': [2801], 'derivative,': [2802], 'Bachem': [2806], '(Bachem': [2807], 'Distribution': [2808], 'Services': [2809], 'GmbH,': [2810], 'Weil': [2811], 'am': [2812], 'Rhein,': [2813], 'Germany),': [2814], 'phosphate': [2816], 'diprotected': [2817], '(methyldiphenylsilyl)ethyl': [2819], 'moiety': [2820], '(37Chao': [2821], 'H.G.': [2822], 'Bernatowicz': [2823], 'M.S.': [2824], 'Reiss': [2825], 'P.D.': [2826], 'Matsueda': [2827], 'G.R.': [2828], 'Org.': [2830], 'Chem.': [2831, 3905, 3974], '59:': [2833], '6687-6691Crossref': [2834], '(25)': [2836], 'Peptides': [2839], 'cleaved': [2841], 'polymer': [2844], 'support': [2845], 'freed': [2847], 'side': [2849], 'chain': [2850], 'protections': [2851], 'trifluoroacetic': [2853], 'acid/triisopropylsilane/water': [2854], '(95/2.5/2.5': [2855], 'volume)': [2857], 'removing': [2862], 'resin': [2864], 'polymer,': [2865], 'peptides': [2867, 2897], 'precipitated': [2869], 'cold': [2871], 'ether': [2872], 'purified': [2874], 'semipreparative': [2876], 'reversed-phase': [2877], 'pressure': [2879], 'liquid': [2880], 'chromatography': [2881], 'C18': [2884], 'column': [2885], '(5': [2886], 'μm,': [2887], '10': [2888, 3416, 3432, 3541, 3573, 3754, 3817, 3827], '250': [2890], 'mm;': [2891], 'Vydac).': [2892], 'molecular': [2894], 'weights': [2895], 'confirmed': [2899], 'mass': [2901], 'spectrometry': [2902], '(electrospray': [2903], 'ionization': [2904], 'm/z': [2905], 'M': [2906], '+': [2907], 'H+:': [2908], '2246.4': [2909], '(Antp)': [2913], '4186.2': [2915], '(pY-pept)).': [2919], 'Immunofluorescent': [2920], 'Staining': [2921], 'Microscopy—Immunostaining': [2923], 'Conventional': [2942], 'phase-contrast': [2943], 'microscopy': [2944, 2965], 'Nikon': [2949], 'TE3000': [2950], 'inverted': [2951], '(Nikon,': [2953], 'Tokyo,': [2954], 'Japan)': [2955], 'equipped': [2956], 'Leica': [2959], 'DC': [2960], 'digital': [2962], 'camera.': [2963], 'Fluorescence': [2964], 'Zeiss': [2970, 2977, 2996, 3025], 'confocal': [2971], 'work': [2972], 'station': [2973], 'attached': [2974], 'LSM': [2978, 2997, 3026], '510': [2979, 2998], 'laser': [2980], '×63': [2984], 'objective': [2985], '(Carl': [2986, 3002, 3030], 'Zeiss,': [2987], 'Thornwood,': [2988], 'NY).': [2989], 'processed': [2994], '(release': [2999], '4.0)': [3000], 'Zeiss).': [3003, 3031], 'At': [3004], 'microscopic': [3008], 'fields': [3009], 'observed': [3011, 3459, 3483, 3539, 3628, 3790, 4048], 'sample.': [3014], 'fiber': [3019], 'length': [3020], 'Examiner': [3028], 'Viability': [3033], 'Assay—Cell': [3034], 'viability': [3035, 3101], 'Cell-Titer': [3039], '96®': [3040], 'AQueous': [3041], 'One': [3042], 'Solution': [3043], 'proliferation': [3045], '(Promega,': [3053], 'Madison,': [3054], 'WI).': [3055], 'distributed': [3059], 'microplates': [3062], '(1.5': [3063, 3149], 'cells/well)': [3066], 'pretreated': [3073, 3146, 3744, 4008, 4172, 4243], 'inhibitors.': [3077], 'then': [3080, 3175, 3236], 'MTS': [3086], 'tetrazolium': [3087], 'solution': [3088], '(provided': [3089], 'manufacturer)': [3092], 'additional': [3095], 'relative': [3099, 3322], 'determining': [3105], 'absorbance': [3107, 3257], '490': [3109], 'nm': [3110, 3260], 'microplate': [3113, 3263], 'reader': [3114, 3264], '(Tecan,': [3115], 'Mannedorf,': [3116], 'Switzerland).': [3117], 'Adhesion': [3119], 'Assay—The': [3120], '(38Aoudjit': [3129], 'Vuori': [3131], 'Blood.': [3133], '95:': [3135], '2044-2051Crossref': [3136], 'minor': [3141], 'modifications.': [3142], 'untreated': [3144, 4064], 'added': [3159], 'anti-LFA-1-coated': [3165, 3762, 3855, 4145], 'microtiter': [3167], '(as': [3169], 'above).': [3171], '°C.': [3182], 'Nonadherent': [3183], 'removed': [3186], 'washing': [3189], 'times': [3191, 3239], 'PBS': [3193, 3202, 3226], 'fixed': [3195], '1%': [3197], 'glutaraldehyde,': [3198], '0.5%': [3199, 3219], 'sucrose': [3200], '15': [3204], 'two': [3210, 3356], 'crystal': [3220], 'violet': [3221], '20%': [3223], 'methanol': [3224], 'plus': [3225], '30': [3228, 3449, 3549], 'washed': [3237], 'five': [3238], 'cell-bound': [3244], 'stain': [3245], 'resolubilized': [3247], 'methanol.': [3249], 'quantified': [3253], 'measuring': [3255], '590': [3259], '(Tecan).': [3265], 'Densitometric': [3266], 'Analysis—Densitometric': [3267], 'analyses': [3268], 'Western': [3271], 'Gene-Tools': [3316], '(Syngene,': [3318], 'Cambridge,': [3319], 'UK).': [3320], 'giving': [3330], 'arbitrary': [3332], 'value': [3333], 'respective': [3338], 'experiment.': [3343], 'Statistical': [3344], 'Analysis—The': [3345], 'data': [3346], 'expressed': [3348], 'mean': [3350], '±': [3351], 'S.E.': [3352], 'For': [3353], 'groups,': [3357], 'p': [3358, 3372], 'two-tailed': [3364], 'unpaired': [3365], "Student's": [3366], 't': [3367], 'test.': [3368], 'In': [3369, 3553], 'all': [3370], 'cases,': [3371], '<': [3373], '0.05': [3374], 'considered': [3376], 'be': [3378, 3957], 'statistically': [3379], 'significant.': [3380], 'Motility': [3382], 'Induced': [3383], 'Cross-linking': [3386], 'Involves': [3387], 'STAT3—In': [3390], 'resting': [3391], 'present': [3396], 'mainly': [3397], 'cytoplasm': [3400], '(Fig.': [3401, 3418, 3434, 3451, 3467, 3551, 3583, 3633, 3768, 3785, 3820, 3837, 4040, 4061, 4105, 4182], '1A).': [3402, 3419, 3435, 3452, 3468], 'Following': [3403, 3516], 'immobilized': [3407, 3465, 3489, 3523, 3589], 'Quantitation': [3420, 3787], 'translocation': [3424, 3441, 3655], 'showed': [3425, 3565], 'up': [3427, 3579, 3598], '42.8%': [3429], 'increase': [3430, 3437, 3531], 'transitory,': [3443], 'returning': [3444], 'basal': [3446], 'level': [3447, 3547], 'after': [3448, 3548], 'similar': [3454], 'profile': [3457], 'ICAM-1': [3466, 3492], 'No': [3469, 3619], 'significant': [3470, 3843, 4134], 'change': [3471, 3620], 'other': [3476], 'isoforms': [3478], 'STAT1': [3479], 'STAT2': [3481], 'either': [3487], '(supplemental': [3497, 3849, 3857, 4139, 4147], 'Fig.': [3498, 3850, 3858, 4140, 4148], '1).': [3499], 'Next,': [3500], 'sought': [3502], 'determine': [3504], 'whether': [3505], 'induced': [3508], 'greater': [3528], 'than': [3529], '7-fold': [3530], '(Tyr705)': [3537], 'min,': [3542], 'declining': [3543], 'toward': [3544], 'base': [3545], '1B).': [3552, 3584, 3634], 'contrast,': [3554], '(TCR)': [3557], 'anti-CD3-induced': [3560], 'distinctly': [3567], 'pattern': [3570], 'detected': [3571], 'remained': [3576, 4117], 'constant': [3577], 'CD3': [3586], 'ligation': [3587], 'anti-CD3': [3590], 'did': [3591, 4175], '(data': [3602, 4122], 'shown).': [3604, 4124], 'Therefore,': [3605, 4150], 'further': [3607, 3716, 4152], 'experiments': [3608], 'employed.': [3618, 4169], 'expression': [3623], 'these': [3630, 3636, 3862, 4120], 'periods': [3632], 'Together,': [3635], 'results': [3637], 'induces': [3646], 'activation,': [3652], 'phosphorylation.': [3658, 3740], 'Suppression': [3659], 'Activity': [3662], 'Attenuates': [3663], 'T-Cell': [3665], 'Polarization': [3666], 'Migration—Hut78': [3668], 'rapidly': [3675], 'polarize': [3676], 'locomotion-associated': [3680, 3783, 4045], 'To': [3715], 'investigate': [3717], 'selective': [3722], 'strategies': [3724], 'utilized.': [3726], 'Initially,': [3727], 'AG490,': [3730], 'Janus': [3732], 'kinase-specific': [3733], 'inhibitor': [3734], 'reduces': [3737], 'concentrations': [3747, 4013], 'ranging': [3750, 4019], 'μm': [3755, 3818, 3828], '2A).': [3769, 3786, 3821], 'Pretreatment': [3770, 3822, 4025, 4125], 'resulted': [3776], 'dose-dependent': [3778, 4038], 'motile': [3796], 'reduced': [3804], '7.9': [3806], 'controls': [3808], '1.8': [3811], 'treated': [3815, 4055, 4068, 4091], '2B).': [3838, 3859], 'treatment': [3840, 4131], 'had': [3841, 4132], 'no': [3842, 4133], '2A)': [3851], 'extended': [3861], 'studies': [3863], 'cell-permeable': [3865, 3942], 'isoform-specific': [3866], 'specifically': [3869], 'targeted': [3870], 'against': [3871], 'STAT3.': [3872], '12-mer': [3874], 'phosphopeptide': [3875], '(AYRNRpYRRQYRY,': [3876], 'where': [3877], 'pY': [3878], 'represents': [3879], 'phosphotyrosine),': [3880], 'combinatorial': [3883], '(39Wiederkehr-Adam': [3885], 'Ernst': [3887], 'Muller': [3889], 'Bieck': [3891], 'Gombert': [3893], 'F.O.': [3894], 'Ottl': [3895], 'Graff': [3897], 'Grossmüller': [3899], 'Heim': [3901], 'M.H.': [3902], '278:': [3907], '16117-16128Abstract': [3908], '(52)': [3916], 'binds': [3919], 'affinity': [3922], 'specificity': [3924], 'BiaCore': [3929], 'competition': [3930], 'assay.': [3931], 'conjugated,': [3935], 'spacer': [3938], '6-aminohexanoic,': [3939], 'called': [3945], 'penetratine': [3946], '(RQIKIWFQNRRMKWKK),': [3949], 'vector': [3951], 'been': [3954], 'shown': [3955], 'efficient': [3959], 'delivering': [3961], 'bioactive': [3962], 'molecules': [3963], '(40Derossi': [3964], 'Joliot': [3966], 'A.H.': [3967], 'Chassaing': [3968], 'Prochiantz': [3970], '269:': [3976], '10444-10450Abstract': [3977], '41Dunican': [3984], 'Doherty': [3986], 'Biopolymers.': [3988], '60:': [3990], '45-60Crossref': [3991], '(62)': [3994], 'Antp': [3997, 4072], 'range': [4011], 'pY-pept': [4015, 4029, 4054, 4095, 4130, 4167, 4174], 'varying': [4017], 'times,': [4018], '12': [4023], 'time-': [4036], 'manner': [4039], '3A).': [4041, 4062], 'Complete': [4042], 'loss': [4043], '25': [4050, 4093], 'μg/ml': [4051, 4094, 4164], 'Control': [4063], 'nonspecific': [4070], 'displayed': [4073], 'elongated': [4077], 'morphology': [4078], '8.1': [4085], '7.8,': [4087], 'respectively,': [4088], 'whereas': [4089], 'almost': [4100], 'round': [4101], '1.78': [4104], '3B).': [4106, 4149], 'attachment': [4109], 'filopodia': [4116], 'intact': [4118], '3A)': [4141], 'experimentations,': [4153], 'short': [4154], 'pretreatment': [4155], 'a25': [4163], '3C).': [4183], 'use': [4185], 'small': [4187, 4198], 'interfering': [4188, 4199], 'RNA-mediated': [4189], 'constrained': [4192], 'capacity': [4195], 'STAT-3-specific': [4197], 'RNA': [4200], 'apoptosis': [4203], 'transfected': [4205], '4N.': [4207], 'Verma,': [4209], 'Dourlat,': 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