Palmitic acid acutely stimulates glucose uptake via activation of Akt and ERK1/2 in skeletal muscle cells

Name: Work Video:
Duration: 3 min 30 s
Pu Jing; Peng Gong; Linghai Li; Huimin Na; Yanbo Liu; Pingsheng Liu
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'https://openalex.org/W1994965139', 'https://openalex.org/W1974550672'], 'abstract_inverted_index': {'Abstract': [0, 184], 'Chronic': [1, 185, 4524], 'exposure': [2, 186, 2842], 'to': [3, 23, 96, 173, 187, 207, 280, 357, 398, 401, 462, 485, 491, 694, 817, 839, 873, 905, 911, 1011, 1039, 1087, 1145, 1187, 1221, 1479, 1504, 1532, 1534, 1570, 1583, 1601, 1650, 1748, 2030, 2047, 2073, 2107, 2140, 2311, 2417, 2495, 2521, 2600, 2667, 2708, 2843, 2874, 2948, 3161, 3186, 3215, 3221, 3231, 3249, 3260, 3266, 3268, 3294, 3312, 3329, 3477, 3563, 3596, 3717, 3754, 3773, 3878, 3907, 3910, 3948, 3985, 4120, 4256, 4341, 4416, 4494, 4866, 4937, 4953, 4965, 5009, 5022, 5071, 5126, 5154, 5178, 5193], 'saturated': [4, 188, 724, 794, 853], 'fatty': [5, 16, 28, 189, 200, 212, 369, 392, 578, 648, 725, 795, 822, 854, 868, 888, 898, 999, 1015, 1149, 1232, 2846, 3025, 3083, 3102, 3306, 3395, 4253, 4269, 4349, 4364, 4407, 4430, 4447, 4498, 4512, 4525, 4533, 4540, 4550, 4577, 4688, 4708, 5003, 5017, 5029, 5049, 5061, 5066], 'acids': [6, 17, 190, 201, 393, 579, 649, 726, 796, 855, 869, 889, 3026, 4254, 4350, 4431, 4513, 4578, 4709, 5004, 5030], 'can': [7, 191, 394, 2783, 2930, 3208, 5056, 5093, 5108, 5133], 'cause': [8, 192, 395], 'insulin': [9, 193, 402, 423, 463, 492, 508, 669, 695, 858, 1119, 1660, 1776, 2403, 3897, 4257, 4273, 4468, 4522, 4607, 4690, 4719, 4744, 4909, 5075], 'resistance.': [10, 194, 4523], 'However,': [11, 195, 3303, 4489, 4957], 'the': [12, 36, 169, 196, 220, 353, 396, 420, 456, 472, 486, 510, 581, 651, 666, 752, 820, 871, 879, 885, 891, 915, 995, 1022, 1118, 1137, 1140, 1153, 1188, 1223, 1557, 1579, 1592, 1594, 1602, 1614, 1652, 1731, 1738, 1741, 1752, 2003, 2114, 2165, 2169, 2188, 2208, 2217, 2222, 2264, 2276, 2297, 2302, 2355, 2418, 2499, 2504, 2508, 2527, 2601, 2634, 2709, 2969, 3019, 3061, 3082, 3216, 3295, 3314, 3330, 3341, 3353, 3364, 3374, 3379, 3382, 3398, 3404, 3408, 3423, 3475, 3598, 3697, 3704, 3725, 3764, 3795, 3828, 3864, 3896, 3908, 3945, 3972, 4005, 4071, 4126, 4159, 4320, 4356, 4405, 4495, 4519, 4544, 4560, 4606, 4650, 4743, 4764, 4786, 4816, 4829, 4838, 4861, 4908, 4950, 4955, 4958, 4975, 5033, 5072, 5078, 5087, 5119], 'acute': [13, 37, 197, 221, 996, 1012, 1146, 1154, 1700, 2356, 2736, 3020, 3336, 4230, 4539, 4549, 4879], 'effects': [14, 38, 198, 222, 997, 1155, 3021, 3074, 4231, 4542, 4546, 4840], 'of': [15, 39, 72, 102, 129, 171, 199, 223, 256, 286, 313, 355, 422, 471, 488, 507, 512, 546, 605, 656, 668, 754, 887, 917, 998, 1066, 1117, 1142, 1156, 1164, 1321, 1366, 1538, 1597, 1613, 1642, 1654, 2045, 2156, 2162, 2221, 2224, 2228, 2267, 2296, 2358, 2433, 2476, 2501, 2511, 2523, 2529, 2561, 2603, 2622, 2637, 2738, 2794, 2851, 3000, 3022, 3063, 3078, 3112, 3147, 3181, 3189, 3195, 3298, 3327, 3347, 3356, 3363, 3367, 3376, 3403, 3441, 3543, 3706, 3893, 3995, 4004, 4062, 4161, 4245, 4267, 4277, 4305, 4450, 4521, 4530, 4547, 4562, 4605, 4656, 4714, 4742, 4766, 4789, 4815, 4841, 4860, 4907, 4960, 4969, 4977, 4996, 5002, 5020, 5054, 5074, 5080, 5086, 5143], 'are': [18, 202, 372, 691, 893, 1029, 2349, 4351, 5124, 5191], 'not': [19, 132, 138, 203, 316, 322, 894, 1091, 2972, 3319, 3459, 3730, 4196, 4216, 4769, 4820, 5045], 'clear': [20, 204], 'and': [21, 46, 60, 78, 108, 115, 121, 134, 176, 180, 205, 230, 244, 262, 292, 299, 305, 318, 360, 364, 403, 419, 458, 519, 521, 553, 583, 746, 907, 914, 925, 974, 1021, 1047, 1161, 1170, 1191, 1205, 1214, 1244, 1254, 1279, 1306, 1315, 1333, 1335, 1422, 1465, 1541, 1578, 1647, 1677, 1704, 1785, 1818, 1843, 1890, 1926, 1951, 1959, 1977, 2014, 2077, 2091, 2117, 2138, 2196, 2212, 2215, 2243, 2274, 2309, 2328, 2462, 2473, 2516, 2550, 2555, 2571, 2582, 2692, 2703, 2750, 2798, 2869, 2904, 2959, 3002, 3036, 3044, 3058, 3069, 3108, 3134, 3151, 3159, 3193, 3264, 3290, 3350, 3387, 3421, 3449, 3456, 3492, 3611, 3621, 3684, 3701, 3703, 3724, 3788, 3807, 3818, 3840, 3853, 3866, 3882, 3921, 3965, 3989, 4078, 4085, 4130, 4208, 4213, 4239, 4247, 4279, 4310, 4336, 4369, 4418, 4474, 4543, 4646, 4659, 4848, 4850, 4863, 4925, 5027, 5052, 5117, 5152, 5164, 5171, 5183], 'need': [22, 206], 'be': [24, 166, 208, 350, 399, 1505, 2741, 2932, 2973, 3320, 3499, 4966, 5057, 5149, 5155], 'elucidated': [25, 209], 'because': [26, 210, 2744], 'plasma': [27, 211, 473, 479, 652, 1189, 2405, 2419, 2505, 3089, 3987, 4251, 4363, 4429, 4446, 4510, 4651, 4932, 4951], 'acid': [29, 213, 370, 823, 829, 899, 1016, 1035, 1059, 1082, 2253, 2270, 2847, 3038, 3071, 3084, 3103, 3114, 3396, 4270, 4365, 4408, 4448, 4499, 4526, 4534, 4541, 4551, 4636, 4784, 5018, 5062, 5067, 5227], 'concentrations': [30, 214, 371, 886, 900, 4449, 4976, 5001], 'fluctuate': [31, 215], 'postprandially.': [32, 216], 'Here,': [33, 217, 4835], 'we': [34, 218, 1151, 2525, 2642, 2926, 3016, 3695, 3767, 3777, 3900, 4055, 4836, 4929, 4992], 'present': [35, 219, 831], 'palmitate': [40, 224, 1475, 1529, 2803, 2844, 5229], '(PA)': [41, 225, 1083], 'on': [42, 149, 226, 333, 445, 509, 1158, 1162, 1543, 1751, 1801, 1816, 2360, 2503, 2513, 2639, 3027, 4538, 4570, 4949, 5118], 'skeletal': [43, 66, 162, 227, 250, 346, 465, 728, 798, 1008, 1064, 1143, 1177, 1351, 2364, 2368, 2490, 2649, 2676, 2723, 2752, 2760, 2805, 2856, 3028, 3183, 3210, 3233, 3676, 3999, 4832, 4844, 5099, 5146], 'muscle': [44, 67, 163, 228, 251, 347, 466, 489, 547, 688, 729, 799, 843, 1144, 1352, 1712, 1779, 2171, 2369, 2491, 2650, 2688, 2724, 2753, 2761, 2806, 2857, 3029, 3184, 3211, 3234, 3677, 4000, 4833, 4845, 5147], 'cells': [45, 164, 229, 348, 576, 1402, 1432, 1723, 1798, 1812, 1862, 1905, 1940, 2006, 2231, 2428, 2438, 2492, 3053, 3185, 3212, 3236, 3241, 3409, 3551, 3610, 3678, 3692, 3806, 3830, 3909, 4182, 5043, 5123], 'their': [47, 231, 5168, 5187], 'underlying': [48, 232, 1023, 1139], 'molecular': [49, 233, 1024], 'mechanisms.': [50, 234], 'Immuno\xadfluorescence': [51, 235], 'results': [52, 236, 2710, 2745, 3143, 3599, 3953, 4140, 4225, 4851, 5089], 'showed': [53, 237, 3144, 3393, 3484, 3728, 3871, 3954, 4113, 4141], 'that': [54, 157, 238, 341, 389, 460, 476, 645, 852, 1182, 1199, 1215, 1617, 2372, 2522, 2591, 2734, 2778, 2870, 2940, 2990, 3145, 3172, 3199, 3207, 3325, 3352, 3394, 3472, 3485, 3496, 3668, 3729, 3750, 3872, 3924, 3938, 3955, 3976, 4114, 4142, 4227, 4507, 4573, 4707, 4853, 4931, 4942, 4994, 5048, 5091], 'PA': [55, 86, 93, 172, 239, 270, 277, 356, 1157, 1183, 1218, 1565, 1809, 2148, 2179, 2242, 2359, 2393, 2411, 2496, 2512, 2546, 2598, 2607, 2638, 2658, 2700, 2717, 2739, 2782, 2935, 2944, 3007, 3129, 3187, 3200, 3229, 3243, 3251, 3263, 3328, 3349, 3357, 3368, 3377, 3380, 3442, 3473, 3486, 3977, 4184, 4229, 4842, 4880, 4934, 4943, 4978, 5092, 5127, 5144], 'rapidly': [56, 240, 2662, 2983, 3738, 3979, 4340, 4496], 'induced': [57, 241], 'GLUT4': [58, 242, 1185, 1750, 1773, 2375, 2407, 2415, 2502, 2514, 2537, 4647, 4770, 4868], 'translocation': [59, 243, 1116, 1186, 1774, 2416, 2515, 4604, 4741, 4869, 4906], 'stimulated': [61, 167, 245, 351, 1184, 2414, 2544, 2718, 3005, 3737, 4972], 'glucose': [62, 113, 159, 246, 297, 343, 408, 480, 840, 1042, 1061, 1093, 1107, 1121, 1159, 1192, 1212, 1709, 2361, 2424, 2487, 2517, 3177, 3196, 3490, 3503, 3582, 3657, 3673, 3710, 3789, 3819, 3887, 3917, 3927, 3991, 4053, 4104, 4122, 4237, 4581, 4595, 4609, 4638, 4732, 4746, 4791, 4855, 4897, 4911, 5111, 5135], 'uptake': [63, 160, 247, 344, 409, 841, 1043, 1062, 1094, 1160, 1193, 1213, 2362, 2425, 2488, 2518, 3491, 3583, 3674, 3790, 3820, 3992, 4105, 4238, 4582, 4639, 4856, 5112, 5136], 'in': [64, 87, 161, 248, 271, 345, 375, 382, 404, 550, 590, 650, 659, 665, 727, 797, 815, 842, 878, 890, 940, 971, 977, 1014, 1045, 1109, 1148, 1176, 1210, 1405, 1440, 1455, 1509, 1659, 1708, 1711, 1777, 1855, 1881, 1930, 1953, 2069, 2093, 2149, 2164, 2176, 2180, 2193, 2281, 2363, 2381, 2400, 2426, 2436, 2489, 2535, 2547, 2563, 2613, 2695, 2721, 2771, 2804, 2855, 2907, 3008, 3047, 3051, 3087, 3101, 3105, 3219, 3501, 3549, 3644, 3675, 3690, 3708, 3721, 3742, 3760, 3827, 3885, 3895, 3915, 3944, 3998, 4064, 4163, 4168, 4228, 4235, 4274, 4317, 4319, 4390, 4410, 4422, 4470, 4475, 4518, 4597, 4640, 4692, 4734, 4794, 4831, 4843, 4882, 4899, 4926, 4988, 5041, 5098, 5145], 'rat': [65, 249, 1110, 1350, 2367, 2675, 2722, 2751, 2759, 3088, 3106, 3182, 4598, 4693, 4735, 4900], 'cell': [68, 174, 252, 358, 1178, 1216, 1347, 1353, 1500, 1586, 1753, 2370, 2651, 2715, 2754, 3331, 3946, 3986, 4846], 'line': [69, 253, 1354, 2371, 2652], 'L6.': [70, 254], 'Phosphorylation': [71, 255, 4968], 'AMP-activated': [73, 257, 1165, 2795, 2852, 2901, 5208], 'protein': [74, 258, 1166, 2079, 2533, 2796, 2853, 2902, 4290, 4308, 4799, 5209], 'kinase': [75, 104, 259, 288, 1167, 1173, 1201, 1656, 2797, 2854, 2903, 3534, 4073, 4800, 5210, 5216, 5223, 5235], '(AMPK),': [76, 260, 1168], 'Akt,': [77, 107, 120, 261, 291, 304, 1169, 1204, 1270, 2530, 3135, 3191], 'extracellular': [79, 263, 1171, 5214], 'signal-related': [80, 264, 1172, 5215], 'kinase1/2': [81, 265], '(ERK1/2)': [82, 266], 'was': [83, 94, 267, 278, 1085, 1291, 1298, 1359, 1384, 1476, 1530, 1568, 1581, 1599, 1616, 1743, 1746, 1984, 1993, 2080, 2158, 2299, 2344, 2388, 2439, 2519, 2543, 2566, 2671, 3004, 3137, 3154, 3237, 3310, 3358, 3443, 3591, 3687, 3715, 3736, 3802, 3809, 3846, 3857, 3883, 4068, 4099, 4106, 4137, 4146, 4158, 4176, 4192, 4233, 4935, 4971, 5014], 'enhanced': [84, 268], 'by': [85, 168, 178, 269, 352, 362, 558, 1063, 1112, 1619, 1680, 1775, 1782, 2097, 2103, 2160, 2207, 2256, 2272, 2441, 2545, 2597, 2802, 2897, 2934, 3006, 3213, 3239, 3389, 3412, 3593, 3739, 3983, 4014, 4070, 4101, 4241, 4272, 4313, 4600, 4643, 4737, 4797, 4902, 5113, 5137], 'a': [88, 272, 591, 602, 606, 662, 883, 990, 1113, 1349, 1385, 1535, 1560, 1609, 1756, 1783, 1802, 1987, 2031, 2108, 2315, 2366, 2377, 2531, 2548, 2592, 2619, 2656, 2961, 3009, 3048, 3204, 3283, 3538, 3568, 3743, 3903, 4420, 4515, 4555, 4601, 4715, 4738, 4798, 4812, 4903, 4980, 5129], 'time-dependent': [89, 273, 3296, 3744], 'manner.': [90, 274], 'Cell': [91, 275, 611, 1283, 1367, 2054], 'surface-bound': [92, 276, 1217], 'sufficient': [95, 279, 1220, 4936], 'stimulate': [97, 281, 2610, 2949, 3042, 3209, 3489, 3718, 3755, 3990], 'Akt': [98, 130, 135, 150, 282, 314, 319, 334, 1266, 1331, 2539, 2562, 2611, 2623, 2640, 2661, 2719, 2876, 2905, 2985, 2995, 3003, 3043, 3272, 3299, 3316, 3337, 3479, 3493, 3497, 3508, 3544, 3565, 3573, 3589, 3613, 3636, 3680, 3685, 3702, 3735, 3756, 3784, 3814, 3855, 3880, 3894, 3922, 3967, 4047, 4189, 4219, 4939, 4970, 4997, 5012, 5034, 5055, 5115, 5231, 5240], 'phosphorylation.': [99, 123, 151, 283, 307, 335], 'The': [100, 284, 505, 1344, 1375, 1564, 1611, 2154, 2230, 2293, 2485, 3140, 3391, 3439, 3481, 3950, 4002, 4060, 4139, 4362, 5082, 5158, 5174], 'inhibitors': [101, 145, 285, 329, 3923, 4076, 4081, 4211], 'PI3': [103, 287, 1200, 5234], '(PI3K),': [105, 289, 1202], 'AMPK,': [106, 119, 290, 303, 1203, 3190], 'ERK1/2': [109, 122, 140, 144, 293, 306, 324, 328, 1206, 1275, 3136, 3169, 4063, 4087, 4097, 4116, 4129, 4144, 4162, 4174, 4199, 4232], 'could': [110, 137, 294, 321, 2609, 2971, 3040, 3318, 3487, 3571, 3633, 3781, 3932, 3958, 3978, 4082], 'decrease': [111, 295, 3580, 3782, 4083], 'PA-induced': [112, 296, 1211, 2994, 3176, 3502, 3581, 3656, 3709, 3783, 3813, 3886, 3960, 4052, 4086, 4103, 4121, 4164, 4198, 4218, 4236], 'uptake,': [114, 298, 3658, 3928, 4054], 'PI3K': [116, 300, 3890, 3905, 3913, 3930, 3939, 3956, 4134, 4157, 4242], 'inhibitor': [117, 136, 301, 320, 3510, 3542, 3770, 3865, 3931, 3957, 4135, 4190], 'decreased': [118, 302, 2577, 3655, 3848, 3859, 3926, 4051, 4148], 'Weakening': [124, 308], 'AMPK': [125, 309, 1272, 1334, 1377, 1678, 2785, 2871, 2929, 2950, 2978, 2991, 3001, 3045, 3133, 3683, 3700, 3707, 3712, 3719, 3732, 3758, 3769, 3775, 3797, 3836, 3842, 3874, 3920, 3961, 4045, 4169, 4246, 5211, 5233], 'activity': [126, 310, 3548, 3881, 4048, 4098, 4788], 'reduced': [127, 311, 3592, 4107], 'phosphorylation': [128, 312, 1163, 1710, 2540, 2720, 2786, 2801, 2951, 2999, 3046, 3146, 3273, 3317, 3574, 3720, 3785, 3815, 3856, 3875, 3968, 4117, 4145, 4175, 4200, 4995, 5013, 5035, 5051], 'but': [131, 315, 1090, 2617, 3733, 4194, 4243, 4435, 4768], 'ERK1/2,': [133, 317, 3192], 'affect': [139, 323, 4197, 4217], 'activation': [141, 325, 2528, 2560, 2602, 2612, 2624, 2850, 2877, 2979, 3300, 3686, 3759, 3962, 3994, 4859], 'either.': [142, 326], 'Meanwhile,': [143, 327], 'had': [146, 330, 439, 3072], 'no': [147, 331], 'effect': [148, 332, 506, 2357, 2510, 2636], 'Taken': [152, 336], 'together,': [153, 337], 'our': [154, 338, 1480, 4927, 5010], 'data': [155, 339, 1196, 2732, 2938, 3392, 3470, 3666, 3870, 3974, 4112], 'suggest': [156, 340, 1198, 2733, 3667, 4226], 'PA-mediated': [158, 342, 2768], 'may': [165, 349, 2740, 2992, 3201, 3498, 4118, 4370, 4528, 4553, 4998], 'binding': [170, 354, 3214, 3230, 3326, 3984], 'surface': [175, 359, 1754, 3217, 3332], 'followed': [177, 361, 2216], 'PI3K/AMPK/Akt': [179, 363, 3996, 4006, 4131, 4862], 'PI3K/ERK1/2': [181, 365, 4864], 'pathways': [182, 366, 4865], 'independently.': [183, 367, 2001], 'Plasma': [368], 'much': [373], 'higher': [374, 4445], 'patients': [376, 941, 4391], 'with': [377, 555, 722, 792, 848, 942, 1411, 1428, 1443, 1458, 1471, 1726, 1760, 1808, 1822, 1851, 1865, 1877, 1893, 1903, 1908, 1923, 1932, 1943, 1948, 1974, 1980, 1999, 2010, 2089, 2129, 2143, 2234, 2240, 2248, 2263, 2376, 2390, 2430, 2478, 2498, 2626, 2683, 2697, 2781, 2943, 3242, 3257, 3344, 3546, 3627, 3863, 4010, 4392, 4454, 4576, 4718, 4946, 5205], 'type': [378, 755, 4476, 4563], '2': [379, 756, 1415, 2146, 2177, 2684, 2698, 4345, 4477, 4564], 'diabetes': [380, 557], 'than': [381, 469, 833, 2984], 'healthy': [383, 4455], 'subjects.': [384], 'Previous': [385, 2774], 'studies': [386, 992, 2775, 4504, 4537, 4569], 'have': [387, 812, 993, 1018, 2776, 4444, 4505], 'shown': [388, 1038, 2399, 2777], 'chronically': [390, 646, 4508], 'elevated': [391, 647, 4509], 'body': [397, 478, 857, 2136, 4491], 'unresponsive': [400], 'turn': [405, 660], 'reduces': [406], 'insulin-stimulated': [407, 1089, 2536], '(1Savage': [410], 'D.B.': [411], 'Petersen': [412], 'K.F.': [413], 'Shulman': [414, 543], 'G.I.': [415, 534], 'Disordered': [416], 'lipid': [417, 594, 634, 1501, 2249, 2304], 'metabolism': [418, 3375, 4271], 'pathogenesis': [421], 'resistance.Physiol.': [424], 'Rev.': [425, 609], '2007;': [426], '87:': [427], '507-526Crossref': [428], 'PubMed': [429, 450, 528, 570, 616, 700, 737, 764, 807, 949, 984, 1075, 1130, 1522, 1672, 1717, 1792, 2059, 2818, 2864, 2920, 3123, 3558, 4038, 4333, 4399, 4484, 4618, 4674, 4698, 4755, 4807, 4920], 'Scopus': [430, 451, 529, 571, 617, 738, 765, 808, 950, 985, 1076, 1131, 1523, 1673, 1718, 1793, 2819, 2865, 2921, 3124, 3559, 4039, 4400, 4485, 4619, 4675, 4699, 4756, 4808, 4921], '(776)': [431], 'Google': [432, 453, 531, 573, 619, 701, 740, 767, 810, 952, 987, 1078, 1133, 1525, 1675, 1720, 1795, 2060, 2821, 2867, 2923, 3126, 3561, 4041, 4286, 4334, 4402, 4487, 4621, 4677, 4701, 4758, 4810, 4923], 'Scholar,': [433, 532, 620, 702, 741, 953, 2822, 4622, 4678], '2McGarry': [434], 'J.D.': [435], 'What': [436], 'if': [437], 'Minkowski': [438], 'been': [440, 1019, 1037, 4876], 'ageusic?': [441], 'An': [442, 4024], 'alternative': [443], 'angle': [444], 'diabetes.Science.': [446], '1992;': [447, 4283], '258:': [448], '766-835Crossref': [449], '(578)': [452], 'Scholar).': [454, 574, 641, 768, 988, 1134, 1526, 1721, 1796, 2061, 2924, 3127, 4042, 4403, 4488, 4702], 'Of': [455], 'tissues': [457, 976, 2066, 4492], 'organs': [459, 3109], 'respond': [461, 1010, 4255, 4493], 'stimulation,': [464], 'consumes': [467], 'more': [468, 2772, 2982, 4092], '70%': [470], 'glucose,': [474], 'suggesting': [475, 851, 2590, 3324, 3495, 3937, 4156, 5047], 'whole': [477], 'concentration': [481, 1537, 3085, 4366, 4409], 'is': [482, 830, 836, 846, 1219, 2872, 2945, 2988, 3333, 3397, 3474, 3752, 3891, 4008, 4826, 5090], 'tightly': [483], 'associated': [484], 'sensitivity': [487], 'tissue': [490, 2025, 2725, 4316], '(3DeFronzo': [493], 'R.A.': [494, 542], 'Jacot': [495], 'E.': [496, 498, 500, 710, 780], 'Jequier': [497], 'Maeder': [499], 'Wahren': [501], 'J.': [502, 565, 3117, 4281, 4292, 4684], 'Felber': [503], 'J.P.': [504, 4628], 'disposal': [511], 'intravenous': [513], 'glucose.': [514], 'Results': [515, 4566], 'from': [516, 580, 903, 1248, 1259, 1282, 1293, 1299, 1309, 1318, 1340, 1361, 1388, 2306, 2712, 3407, 3600, 4353, 4414, 4567], 'indirect': [517], 'calorimetry': [518], 'hepatic': [520], 'femoral': [522], 'venous': [523], 'catheterization.Diabetes.': [524], '1981;': [525], '30:': [526], '1000-1006Crossref': [527], '(1408)': [530], '4Shulman': [533], 'Rothman': [535], 'D.L.': [536], 'Jue': [537], 'T.': [538, 1624, 1626, 2889, 2891, 3093, 3097, 4021], 'Stein': [539], 'P.': [540, 628, 929, 1485, 2038, 4379], 'DeFronzo': [541], 'R.G.': [544, 599, 1495, 2042], 'Quantitation': [545], 'glycogen': [548], 'synthesis': [549], 'normal': [551, 1046], 'subjects': [552, 554, 4456, 4473], 'non-insulin-dependent': [556], '13C': [559], 'nuclear': [560], 'magnetic': [561], 'resonance': [562], 'spectroscopy.N.': [563], 'Engl.': [564], 'Med.': [566], '1990;': [567, 981], '322:': [568], '223-230Crossref': [569], '(1056)': [572], 'Muscle': [575, 744], 'ingest': [577], 'blood': [582, 872, 892, 3107, 4357, 4411], 'store': [584], 'them': [585], 'as': [586, 866, 921, 923, 1007, 1608, 2408, 2655, 2756, 2758, 2954, 2956, 3203, 3359, 3361, 3577, 3579, 3849, 4180, 4358], 'intramyocellular': [587, 5217], 'triglycerides': [588, 745], '(IMTGs)': [589], 'cellular': [592, 631, 2075], 'organelle': [593, 632], 'droplet': [595], '(5Martin': [596], 'S.': [597, 622, 674, 933, 1055, 2788, 2828, 2832, 2883, 3095, 4383, 4634], 'Parton': [598], 'Lipid': [600, 629, 1242, 2307, 2808, 4323], 'droplets:': [601], 'unified': [603], 'view': [604, 4557], 'dynamic': [607], 'organelle.Nat.': [608], 'Mol.': [610], 'Biol.': [612, 1512, 1662, 2910, 4664], '2006;': [613, 2810], '7:': [614, 947, 4397], '373-380Crossref': [615], '(929)': [618], '6Zhang': [621], 'Du': [623], 'Y.': [624, 626, 1487, 1489, 1634, 1640, 1770], 'Wang': [625, 4020], 'Liu': [627, 2037, 3518, 4775], 'droplet—a': [630], 'for': [633, 751, 1370, 1585, 1859, 1873, 1887, 1897, 1917, 1965, 2187, 2258, 2290, 2748, 3244, 3335, 4439, 4558, 4654, 5128, 5167, 5186, 5197], 'metabolism.Acta': [635], 'Biophisica': [636], 'Sinica.': [637], '2010;': [638], '26:': [639], '97-105Google': [640], 'Mounting': [642], 'evidence': [643, 4706], 'indicates': [644], 'induce': [653, 2784, 2875, 3478, 4938], 'excess': [654], 'storage': [655], 'IMTG,': [657], 'which': [658, 1355, 3079, 3748], 'plays': [661], 'key': [663, 2532], 'role': [664, 3705, 3943, 4061, 4276, 4517], 'development': [667, 753, 4520, 5073], 'resistance': [670, 719, 789, 4469, 4691, 5076], '(7Pan': [671], 'D.A.': [672], 'Lillioja': [673], 'Kriketos': [675], 'A.D.': [676, 3525, 4300], 'Milner': [677], 'M.R.': [678], 'Baur': [679], 'L.A.': [680, 1695], 'Bogardus': [681], 'C.': [682, 1693, 4624], 'Jenkins': [683], 'A.B.': [684], 'Storlien': [685], 'L.H.': [686], 'Skeletal': [687, 2687], 'triglyceride': [689, 3457, 5218], 'levels': [690, 1017, 3615, 4343, 4500, 4648], 'inversely': [692], 'related': [693], 'action.Diabetes.': [696], '1997;': [697], '46:': [698], '983-990Crossref': [699], '8Manco': [703], 'M.': [704, 743, 774, 937, 1493, 2830, 2834, 2836, 2885, 3517, 3527, 3531, 4387, 4462], 'Mingrone': [705, 775], 'G.': [706, 717, 776, 787], 'Greco': [707, 777], 'A.V.': [708, 778], 'Capristo': [709, 779], 'Gniuli': [711, 781], 'D.': [712, 782, 1685, 4776], 'De': [713, 783], 'Gaetano': [714, 784], 'A.': [715, 785, 1687, 1697, 1772], 'Gasbarrini': [716, 786], 'Insulin': [718, 788, 4872], 'directly': [720, 790, 2009], 'correlates': [721, 791], 'increased': [723, 793, 2404, 2440, 2486, 3155, 4178], 'triglycerides.Metabolism.': [730, 800], '2000;': [731, 801], '49:': [732, 802], '220-223Abstract': [733, 803], 'Full': [734, 804, 1517, 1519, 1667, 1669, 2813, 2815, 2915, 2917, 4328, 4330, 4669, 4671], 'Text': [735, 805, 1518, 1520, 1668, 1670, 2814, 2816, 2916, 2918, 4329, 4331, 4670, 4672], 'PDF': [736, 806, 1521, 1671, 2817, 2919, 4332, 4673], '(141)': [739, 809], '9Roden': [742], 'mitochondrial': [747, 1701], 'function:': [748], 'possible': [749, 2989, 3753, 4058], 'mechanisms': [750, 1025, 4817], 'diabetes.Int': [757], 'J': [758], 'Obes': [759], '(Lond).': [760], '2005;': [761, 1714], '29:': [762], 'S111-S115Crossref': [763], '(117)': [766], 'Furthermore,': [769, 3060, 3826], 'Manco': [770], 'et': [771, 1621, 1682, 3532, 4016], 'al.': [772, 1622, 1683], '(8Manco': [773], 'Scholar)': [811, 2868, 3562], 'suggested': [813], 'that,': [814], 'addition': [816], 'IMTG': [818, 821], 'concentration,': [819], 'fraction': [824], 'pattern,': [825], 'i.e.,': [826], 'whether': [827, 2928, 3912], 'palmitic': [828, 1081, 5226], 'rather': [832], 'oleic': [834, 3034, 3067], 'acid,': [835, 3033, 3035, 3066, 3068], 'significantly': [837, 3461, 3584, 4108], 'correlated': [838, 2497], 'tissue.': [844, 2762], 'This': [845, 5140], 'consistent': [847, 3862, 4009, 4813], 'other': [849, 3023, 4057, 4337, 4761, 5120], 'reports': [850, 4704, 4762], 'suppress': [856, 3774], 'sensitivity.': [859], 'During': [860, 3128], 'fasting,': [861], 'adipocytes': [862, 1111, 4354, 4571, 4599, 4642, 4736, 4796, 4884, 4901], 'release': [863, 4304], 'stored': [864, 2197], 'lipids': [865, 2245, 3384, 3406], 'free': [867, 4252, 4268, 4348, 4406, 4511], 'into': [870, 1382, 1435, 3608, 3804, 4355], 'provide': [874, 4705], 'an': [875, 1705, 1933, 3507, 3941, 4359], 'energy': [876, 4360], 'source': [877], 'animal': [880, 2203], 'body.': [881], 'As': [882, 2398, 2977, 3567, 3640], 'result,': [884, 2657, 3569], 'consistent.': [895], 'In': [896, 2605, 2997, 3587], 'fact,': [897], 'vary': [901, 4433], 'widely': [902], 'hour': [904, 906, 4415, 4417], 'display': [908, 4436], 'waves': [909], 'according': [910, 1478, 2029], 'nutritional': [912], 'state': [913], 'presence': [916], 'regulators': [918], 'including': [919], 'hormones,': [920], 'well': [922, 2757, 3578], 'metabolic': [924, 1506], 'neural': [926], 'signals': [927], '(10Singer': [928, 4378], 'Godicke': [930, 4380], 'W.': [931, 2023, 4381], 'Voigt': [932, 4382], 'Hajdu': [934, 4384], 'I.': [935, 4385], 'Weiss': [936, 4386], 'Postprandial': [938, 968, 4388], 'hyperinsulinemia': [939, 4389], 'mild': [943, 4393], 'essential': [944, 1407, 3942, 4394], 'hypertension.Hypertension.': [945, 4395], '1985;': [946, 4396], '182-187Crossref': [948, 4398], '(167)': [951, 4401], '11Coppack': [954], 'S.W.': [955], 'Fisher': [956], 'R.M.': [957], 'Gibbons': [958], 'G.F.': [959], 'Humphreys': [960], 'S.M.': [961], 'McDonough': [962], 'M.J.': [963], 'Potts': [964], 'J.L.': [965], 'Frayn': [966, 4301], 'K.N.': [967, 4302], 'substrate': [969], 'deposition': [970], 'human': [972, 4314], 'forearm': [973], 'adipose': [975, 4315], 'vivo.Clin.': [978], 'Sci.': [979, 2055], '(Lond.).': [980], '79:': [982], '339-386Crossref': [983], '(158)': [986], 'Although': [989], 'few': [991], 'reported': [994, 1086], 'acids,': [1000, 1150], 'conclusions': [1001], 'concerning': [1002], 'how': [1003, 4490], 'energy-consuming': [1004], 'tissues,': [1005, 4849], 'such': [1006], 'muscle,': [1009, 2365], 'rises': [1013], 'inconsistent': [1020], 'controlling': [1026], 'these': [1027, 2731, 3665], 'responses': [1028, 3180], 'still': [1030, 3422, 4177, 4963], 'unclear.': [1031, 4502], 'For': [1032, 1591], 'example,': [1033, 4440], 'α-lipoic': [1034], 'has': [1036, 4819, 4875], 'enhance': [1040, 5134], 'basal': [1041, 1092, 3162, 4084, 4342, 4580], 'both': [1044, 3148], 'ob/ob': [1048, 1068], 'mice': [1049], '(12Eason': [1050], 'R.C.': [1051], 'Archer': [1052], 'H.E.': [1053], 'Akhtar': [1054], 'Bailey': [1056], 'C.J.': [1057], 'Lipoic': [1058], 'increases': [1060, 1147, 4367, 4579], 'muscles': [1065], 'obese-diabetic': [1067], 'mice.Diabetes': [1069], 'Obes.': [1070], 'Metab.': [1071], '2002;': [1072, 4481], '4:': [1073], '29-35Crossref': [1074], '(45)': [1077, 1132, 4620, 4757, 4922], 'Scholar),': [1079, 1676, 4287, 4335, 4759, 4924], 'whereas': [1080, 3452, 3659, 4089, 4760], 'treatment': [1084, 1587, 1807, 2239, 2412, 2477, 2780, 2942, 3741, 4185, 4575, 4881], 'inhibit': [1088, 5109], '(13Hardy': [1095, 4583, 4720, 4885], 'R.W.': [1096, 4584, 4682, 4721, 4886], 'Ladenson': [1097, 4585, 4722, 4887], 'J.H.': [1098, 4586, 4723, 4888], 'Henriksen': [1099, 4587, 4724, 4889], 'E.J.': [1100, 4588, 4725, 4890], 'Holloszy': [1101, 4589, 4726, 4891], 'J.O.': [1102, 4263, 4590, 4727, 4892], 'McDonald': [1103, 4591, 4685, 4728, 4893], 'J.M.': [1104, 4592, 4630, 4686, 4729, 4894], 'Palmitate': [1105, 4593, 4730, 4895], 'stimulates': [1106, 2895, 4594, 4637, 4731, 4785, 4896], 'transport': [1108, 4596, 4733, 4898], 'mechanism': [1114, 1138, 4602, 4739, 4904], 'involving': [1115, 4603, 4740, 4905], 'sensitive': [1120, 4608, 4745, 4910], 'transporter': [1122, 4610, 4747, 4792, 4912], '(GLUT4).Biochem.': [1123, 4611, 4748, 4913], 'Biophys.': [1124, 4612, 4749, 4914], 'Res.': [1125, 2809, 3554, 4034, 4324, 4480, 4613, 4750, 4915], 'Commun.': [1126, 4614, 4751, 4916], '1991;': [1127, 3120, 4615, 4752, 4917], '177:': [1128, 4616, 4753, 4918], '343-351Crossref': [1129, 4617, 4754, 4919], 'To': [1135, 2353, 2632, 3225, 3372, 4124], 'elucidate': [1136, 1651], 'response': [1141, 2737, 3947], 'examined': [1152, 1928, 2526, 3018, 4069], '(ERK)': [1174], '1/2': [1175, 4075], 'lines.': [1179], 'We': [1180, 2421, 2763, 3339, 3505, 5190], 'found': [1181, 3351, 3778, 4930], 'membrane': [1190, 1510, 1702, 3218, 3988, 4952], 'enhancement.': [1194], 'Our': [1195, 2937], 'also': [1197, 2413, 2608, 2659, 2931, 2946, 3017, 3138, 3734, 3824, 3858, 4432, 5176], 'play': [1207, 4514, 5094], 'critical': [1208, 4516, 5169], 'roles': [1209, 1653, 5097], 'trigger': [1222, 3980, 4954], 'signal': [1224, 2593, 2970, 3270, 3670, 3898, 3981, 4066, 4165, 5036], 'transduction.': [1225, 3271, 4166], 'Sodium': [1226, 1474], 'PA,': [1227, 1944, 2481, 3015, 3064], 'insulin,': [1228, 1811, 2524], 'myc': [1229, 2378], 'polyclonal': [1230, 1869], 'antibody,': [1231], 'acid-free': [1233, 3307], 'BSA,': [1234], '5-aminoimidazole-4': [1235], 'carboxamide': [1236], '1-β-D-ribofuranoside': [1237], '(AICAR),': [1238], 'Compound': [1239, 3771, 3779], 'C,': [1240, 3057], 'API-2,': [1241], 'Standard,': [1243], '2-deoxy-D-glucose': [1245], 'were': [1246, 1257, 1281, 1308, 1317, 1339, 1403, 1433, 1453, 1724, 1799, 1813, 1863, 1906, 1941, 1969, 2007, 2027, 2067, 2087, 2101, 2126, 2173, 2205, 2232, 2246, 2261, 2279, 2321, 2335, 2681, 2690, 2746, 3254, 3385, 3606, 3616, 3823, 5031], 'purchased': [1247, 1292], 'Sigma-Aldrich': [1249], '(St.': [1250], 'Louis,': [1251], 'MO).': [1252], '2-Deoxy-D-[3H]glucose': [1253], 'TLC': [1255, 2277], 'plates': [1256, 2278, 2298], 'obtained': [1258, 1360, 2711], 'GE': [1260], 'Healthcare': [1261], '(UK).': [1262], 'Antibodies': [1263], 'against': [1264], 'phosphorylated': [1265, 1271, 1274, 5230], '(Ser': [1267, 2541], '473),': [1268], 'total': [1269, 2078, 2244, 3383, 3405, 3612], '(Thr172),': [1273], '(p44/42': [1276], 'MAPK)': [1277], '(Thr202/Tyr204),': [1278], 'GAPDH': [1280], 'Signaling': [1284], 'Technology': [1285], '(Beverly,': [1286], 'MA).': [1287, 1296, 1304], 'Myc': [1288], 'monoclonal': [1289], 'antibody': [1290, 1870], 'Upstate': [1294], '(Billerica,': [1295], '3H-PA': [1297], 'PerkinElmer': [1300], 'Life': [1301], 'Sciences': [1302, 1397], '(Waltham,': [1303], 'LY294002': [1305, 4136], 'API-2': [1307, 3511, 3570, 4191], 'Biomol': [1310], '(Plymouth': [1311], 'Meeting,': [1312], 'PA).': [1313], 'PD98058': [1314], 'U0126': [1316, 4090, 4214], 'Beyotime': [1319], 'Institute': [1320, 2223], 'Biotechnology': [1322], '(Haimen,': [1323], 'China).': [1324, 1343], 'Short': [1325], 'interference': [1326, 3595, 5237, 5242], 'RNA': [1327, 1643, 3594, 5238, 5243], '(siRNA)': [1328], 'duplex': [1329, 3833], 'targeting': [1330, 2044, 3835, 5239], '(siAkt)': [1332], 'negative': [1336, 1379, 3628, 3799, 5213, 5224], 'control': [1337, 3629, 5225], 'siRNA': [1338, 1727, 3604, 3630, 3832, 4171], 'GenePharma': [1341], '(Shanghai,': [1342], 'L6-GLUT4myc': [1345, 1401, 1797, 1939, 2386], '(L6)': [1346], 'line,': [1348], 'stably': [1356, 2373], 'over-expresses': [1357], 'GLUT4,': [1358], 'Dr.': [1362, 1389, 5194], 'Amira': [1363], 'Klip,': [1364], 'Division': [1365], 'Biology,': [1368], 'Hospital': [1369], 'Sick': [1371], 'Children,': [1372], 'Toronto,': [1373], 'Canada.': [1374], 'myc-tagged': [1376, 3796], 'dominant': [1378, 3798, 5212], 'mutant': [1380], 'constructed': [1381], 'pcDNA3.1': [1383], 'kind': [1386], 'gift': [1387], 'David': [1390, 5195], 'Carling,': [1391], 'Cellular': [1392], 'Stress': [1393], 'Group,': [1394], 'MRC': [1395], 'Clinical': [1396], 'Centre,': [1398], 'London,': [1399], 'UK.': [1400], 'maintained': [1404, 1454], 'α-minimal': [1406], 'medium': [1408, 1441, 1572, 1580, 1604], '(α-MEM)': [1409], 'supplemented': [1410, 1442, 1457], '10%': [1412, 1459, 1574, 1606, 2104, 2152, 2183], '(v/v)': [1413, 1460], 'FBS,': [1414, 1461], 'µg/ml': [1416], 'blasticidin': [1417], 'S,': [1418], '100': [1419, 1423, 1462, 1466, 1539, 2395], 'units/ml': [1420, 1424, 1463, 1467], 'penicillin,': [1421, 1464], 'streptomycin': [1425, 1468], 'at': [1426, 1469, 1545, 1576, 1857, 1871, 1885, 1920, 1963, 1997, 2021, 2185, 2198, 2287, 2573, 2963, 3247, 3285, 3301, 3415, 3433, 3618, 3648, 4649, 4711], '37°C': [1427, 1470, 1584, 1964, 2186, 3267, 3434], '5%': [1429, 1472, 1852], 'CO2.': [1430, 1473], 'L6': [1431, 1722, 2427, 2437, 2564, 2615, 2627, 3052, 3609, 3722, 3761, 3805, 3829], 'differentiated': [1434, 2614], 'myotubes': [1436, 2616], 'within': [1437, 4344, 4375, 5059], '7': [1438], 'days': [1439], '2%': [1444], 'FBS.': [1445, 2153], 'Mouse': [1446], 'C2C12': [1447, 3235, 4989, 5042], 'myoblasts': [1448, 2565, 2628], '(American': [1449], 'Type': [1450], 'Culture': [1451], 'Collection)': [1452], 'DMEM': [1456], 'prepared': [1477, 2028], 'previously': [1481, 1757, 2032], 'published': [1482, 1758, 2033, 4012], 'method': [1483, 1759, 2034], '(14Liu': [1484], 'Ying': [1486], 'Zhao': [1488], 'Mundy': [1490], 'D.I.': [1491], 'Zhu': [1492], 'Anderson': [1494, 2041], 'Chinese': [1496, 2226], 'hamster': [1497], 'ovary': [1498], 'K2': [1499], 'droplets': [1502], 'appear': [1503], 'organelles': [1507], 'involved': [1508, 2534, 3500, 3884, 4234, 4818], 'traffic.J.': [1511], 'Chem.': [1513, 1663, 2911, 4665], '2004;': [1514, 2912, 3555], '279:': [1515, 2913], '3787-3878Abstract': [1516], '(438)': [1524], 'Briefly,': [1527, 2062], 'sodium': [1528], 'added': [1531, 1569, 1600], 'ethanol': [1533, 1598], 'final': [1536], 'mM': [1540, 1829, 1832, 1835, 1838, 1841, 1845, 1895, 2147, 2178, 2685, 2699], 'sonicated': [1542, 2015, 2068], 'ice': [1544, 1817], '200': [1546, 2022, 4986], 'W': [1547], 'using': [1548, 1755, 1986, 2082, 2113, 2119, 2314, 2323, 2337, 2647, 2674, 2714, 3602], '10': [1549, 1860, 1899, 2569, 3286, 3430], 's': [1550, 1553, 2018], 'on,': [1551], '3': [1552, 2586, 5023, 5039], 'off': [1554], 'pulses': [1555], 'until': [1556, 2200], 'mixture': [1558, 3834], 'became': [1559, 2583], 'milky': [1561], 'homogenous': [1562], 'solution.': [1563], 'stock': [1566], 'solution': [1567], 'growth': [1571, 1603], 'containing': [1573, 1605, 1955, 2151, 2182], 'FBS': [1575, 1607, 2184], '60°C': [1577], 'cooled': [1582], 'unless': [1588], 'otherwise': [1589], 'stated.': [1590], 'control,': [1593], 'same': [1595, 3342], 'amount': [1596, 3355, 3366], 'vehicle.': [1610], 'sequence': [1612], 'siAkt': [1615, 3632, 3653], 'given': [1618], 'Katome': [1620], '(15Katome': [1623], 'Obata': [1625], 'Matsushima': [1627], 'R.': [1628, 2838], 'Masuyama': [1629], 'N.': [1630, 1691, 2879, 4265, 4458], 'Cantley': [1631], 'L.C.': [1632], 'Gotoh': [1633], 'Kishi': [1635, 1767], 'K.': [1636, 1768, 2887, 2893, 3091, 4296], 'Shiota': [1637], 'H.': [1638, 2881, 4023], 'Ebina': [1639, 1769], 'Use': [1641, 2213, 2219], 'interference-mediated': [1644], 'gene': [1645], 'silencing': [1646], 'adenoviral': [1648], 'overexpression': [1649], 'AKT/protein': [1655], 'B': [1657, 3535], 'isoforms': [1658], 'actions.J.': [1661], '2003;': [1664], '278:': [1665], '28312-28334Abstract': [1666], '(174)': [1674], 'α': [1679, 3843], 'Konrad': [1681], '(16Konrad': [1684], 'Rudich': [1686], 'Bilan': [1688], 'P.J.': [1689, 4259, 4464], 'Patel': [1690], 'Richardson': [1692], 'Witters': [1694], 'Klip': [1696, 1771], 'Troglitazone': [1698], 'causes': [1699], 'depolarisation': [1703], 'AMPK-mediated': [1706], 'increase': [1707], 'cells.Diabetologia.': [1713], '48:': [1715], '954-1019Crossref': [1716], '(99)': [1719], 'nucleofected': [1725, 3607, 3803], 'or': [1728, 1737, 1810, 2052, 2394, 4046, 4984, 5228], 'plasmids': [1729], 'following': [1730, 2301], "manufacturer's": [1732], 'procedure.': [1733], 'After': [1734, 1806, 1849, 1901, 2002, 2167, 2678, 2966, 4249], '48': [1735, 3649], 'h,': [1736, 1875, 2581, 2968], 'times': [1739, 1821, 1947, 1973, 1996, 2189], 'indicated,': [1740, 2005, 2116, 2190], 'analysis': [1742], 'performed.': [1744], 'Immunofluorescence': [1745], 'used': [1747, 3311, 3716, 3768, 4193], 'detect': [1749], 'slight': [1761], 'modifications': [1762], '(17Wang': [1763], 'Q.': [1764, 3519], 'Khayat': [1765], 'Z.': [1766], 'intact': [1778], 'cells:': [1780], 'detection': [1781], 'fast': [1784], 'quantitative': [1786], 'assay.FEBS': [1787], 'Lett.': [1788], '1998;': [1789, 4325], '427:': [1790], '193-199Crossref': [1791], '(188)': [1794], 'seeded': [1800], 'glass-bottomed': [1803], 'plate': [1804], 'overnight.': [1805], 'immediately': [1814, 1929, 2191], 'placed': [1815], 'washed': [1819, 1876, 1922, 1945, 1971, 2088, 3256], 'three': [1820, 1946, 1972, 1995], 'ice-cold': [1823, 1878, 1924, 1975, 3258], 'Krebs-Ringer': [1824, 5219], 'HEPES': [1825, 5220], 'buffer': [1826, 2013, 2072, 2096, 3414, 5221], '(KRBH)': [1827], '(120': [1828], 'NaCl,': [1830], '25': [1831], 'HEPES,': [1833], '4.6': [1834], 'KCl,': [1836], '1': [1837, 1874, 2133, 2580, 2666, 2967, 3245, 3465], 'MgSO4,': [1839], '1.2': [1840], 'KH2PO4,': [1842], '1.9': [1844], 'CaCl2,': [1846], 'pH': [1847], '7.4).': [1848], 'blocking': [1850, 4044, 5114], 'goat': [1853, 1912], 'serum': [1854], 'KRBH': [1856, 1931, 1954, 1976, 3259, 3309, 3413, 3447], '4°C': [1858, 1872, 1886, 3248, 3416], 'min,': [1861, 1889, 2575], 'incubated': [1864, 1892, 1907, 1952, 2175, 2694], '2.5': [1866], 'mg/ml': [1867], 'anti-myc': [1868], 'KRBH,': [1879, 1904, 1925, 1950], 'fixed': [1880], '3%': [1882], 'formaldehyde': [1883], '(PFA)': [1884], '20': [1888, 2144, 2291, 2964], 'then': [1891, 1927, 1970, 1978, 2275, 2422, 2576, 2693, 2764, 3255], '50': [1894, 1960], 'NH4Cl': [1896], 'another': [1898], 'min.': [1900, 1967, 2292, 2965], 'washing': [1902, 3411, 3448], 'fluorescein': [1909], 'isothiocyanat': [1910], '(FITC)-conjugated': [1911], 'anti-rabbit': [1913], 'IgG': [1914], '(1:500': [1915], 'dilution)': [1916], '45': [1918, 2574], 'min': [1919, 2475, 2570, 2958, 3158, 3166, 3277, 3287, 3431], '4°C,': [1921], 'Olympus': [1934], 'FV500': [1935], 'confocal': [1936], 'fluorescence': [1937], 'microscope.': [1938], 'treated': [1942, 2389, 2429], 'prewarmed': [1949], '0.5': [1956], 'μCi/ml': [1957], '2-deoxy-D-[3H]glucose': [1958], 'μM': [1961, 2392, 2480, 4374, 4452, 4987], '2-deoxy-glucose': [1962, 2435], '5': [1966, 2957, 3157, 3276], 'Cells': [1968, 3253], 'lysed': [1979, 2008, 2233], '1%': [1981, 2235], 'SDS.': [1982], 'Radioactivity': [1983], 'measured': [1985, 2423], 'Perkin-Elmer': [1988, 2316], 'scintillation': [1989, 2312, 2317], 'counter.': [1990, 2318], 'Each': [1991], 'experiment': [1992, 3343], 'performed': [1994, 2322, 3647], 'least': [1998, 4712], 'triplicate': [2000], 'treatments': [2004, 5019], '2×SDS': [2011, 2070, 2094], 'sample': [2012, 2071, 2095], 'twice': [2016], '(7': [2017], 'each': [2019], 'time)': [2020], 'Rat': [2024], 'samples': [2026], '(18Li': [2035], 'W.P.': [2036], 'Pilcher': [2039], 'B.K.': [2040], 'Cell-specific': [2043], 'caveolin-1': [2046], 'caveolae,': [2048], 'secretory': [2049], 'vesicles,': [2050], 'cytoplasm': [2051], 'mitochondria.J.': [2053], '2001;': [2056, 4666], '114:': [2057], '1397-1408Crossref': [2058], '50–70': [2063], 'mg': [2064], 'wet': [2065], 'dissolve': [2074], 'protein,': [2076], 'precipitated': [2081], '7.2%': [2083], 'TCA.': [2084], 'Protein': [2085], 'pellets': [2086], 'acetone': [2090], 'dissolved': [2092], 'sonication.': [2098], 'Total': [2099], 'proteins': [2100], 'resolved': [2102], 'SDS-PAGE,': [2105], 'transferred': [2106, 3265], 'polyvinylidene': [2109], 'fluoride': [2110], 'membrane,': [2111], 'blotted': [2112], 'antibodies': [2115], 'detected': [2118, 2974, 3321], 'ECL.': [2120], 'Male': [2121], 'Sprague-Dawley': [2122], 'rats': [2123, 2680], '(200–250': [2124], 'g)': [2125], 'anesthetized': [2127], 'intraperitoneally': [2128], 'chloral': [2130], 'hydrate': [2131], '(10%,': [2132], 'ml/200': [2134], 'g': [2135], 'weight)': [2137], 'subjected': [2139, 2310], 'transcardiac': [2141], 'perfusion': [2142, 2157], 'ml': [2145], 'saline': [2150, 2181], 'success': [2155], 'confirmed': [2159], 'loss': [2161], 'color': [2163], 'liver.': [2166], 'perfusion,': [2168], 'soleus': [2170], 'strips': [2172, 2689], 'isolated,': [2174], 'frozen': [2192], 'liquid': [2194], 'nitrogen,': [2195], '−80°C': [2199], 'required.': [2201], 'All': [2202, 3971], 'experiments': [2204, 2646, 2713, 3483, 3601], 'approved': [2206], 'Institutional': [2209], 'Animal': [2210, 2218], 'Care': [2211], 'Committee': [2214], 'Guidelines': [2220], 'Biophysics,': [2225], 'Academy': [2227], 'Sciences.': [2229], 'triton': [2236], 'X-100': [2237], 'after': [2238, 2284, 2467, 2568, 2579, 2585, 3110, 3156, 3164, 3275, 3410, 3429, 3624, 3651, 4183, 4878, 5016, 5038], '3H-labled': [2241], 'extracted': [2247, 3386], 'extract': [2250], 'reagent': [2251], '(chloroform-methanol-acetic': [2252], '=': [2254], '50:50:1,': [2255], 'vol)': [2257], 'TLC.': [2259, 3390], 'Chromatograms': [2260], 'developed': [2262], 'developing': [2265], 'solvent': [2266], 'N-hexane-diethyl': [2268], 'ether-acetic': [2269], '(80:20:1,': [2271], 'vol),': [2273], 'stained': [2280], 'iodine': [2282], 'vapor': [2283], 'being': [2285], 'air-dried': [2286], 'room': [2288], 'temperature': [2289], 'silica': [2294], 'gel': [2295], 'scraped': [2300], 'separated': [2303, 3388], 'bands': [2305], 'Standard': [2308], 'counting': [2313], 'Statistical': [2319], 'analyses': [2320, 3646], 'Microsoft': [2324], 'Office': [2325], 'Excel': [2326], '2007': [2327], 'OriginPro': [2329], '7.5.': [2330], 'Differences': [2331], 'among': [2332], 'relevant': [2333, 2743], 'groups': [2334], 'assessed': [2336], 'unpaired': [2338], "Student's": [2339], 't-tests.': [2340], 'P': [2341], '<': [2342, 2444, 2448, 2452, 2456, 2460, 2465], '0.05': [2343], 'considered': [2345], 'significant.': [2346], 'Values': [2347], 'presented': [2348], 'means': [2350], '±': [2351, 3401, 3427], 'SD.': [2352], 'determine': [2354, 3911, 4125], 'expresses': [2374], 'tag': [2379], 'located': [2380], 'its': [2382, 3223], 'first': [2383], 'exofacial': [2384], 'loop,': [2385], '(L6),': [2387], '300': [2391, 2479], 'nM': [2396], 'insulin.': [2397], 'Fig.': [2401, 2557, 2630, 2705, 3055, 3076, 3641], '1A,': [2402], 'membrane-localized': [2406], 'expected.': [2409], 'Surprisingly,': [2410], 'membrane.': [2420, 2506, 4652], 'PA.': [2431, 2686, 3949], 'Uptake': [2432], '3H-labeled': [2434, 3348], '28%': [2442], '(P': [2443, 2447, 2451, 2455, 2459, 2464], '0.05),': [2445], '69%': [2446], '0.001),': [2449, 2453, 2457, 2461], '76%': [2450], '93%': [2454], '86%': [2458], '85%': [2463], '0.001)': [2466], '5,': [2468], '10,': [2469], '15,': [2470], '20,': [2471], '30,': [2472], '60': [2474], 'respectively': [2482], '(Fig.': [2483, 2553, 2588, 2663, 2701, 2726, 2975, 3012, 3167, 3278, 3370, 3417, 3435, 3462, 3575, 3585, 3638, 3693, 3746, 3786, 3791, 3811, 3816, 3821, 3851, 3860, 3935, 3963, 3969, 4094, 4109, 4149, 4186, 4201, 4222, 4870, 5025], '1B).': [2484], 'acutely': [2493, 3041, 3488], 'exposed': [2494, 5125], 'localization': [2500], 'Because': [2507, 3682, 3889, 4043], 'stimulatory': [2509, 2635], 'similar': [2520, 2645, 2747, 3073, 3293], 'translocation.': [2538], '473)': [2542], 'time-': [2549], 'dose-dependent': [2551, 3010, 3049], 'manner': [2552, 3011, 3050, 3297, 3745], '1C-E': [2554], 'supplementary': [2556, 2704], 'IA).': [2558, 2631], 'Interestingly,': [2559, 3031], 'observed': [2567, 3688, 4877], 'peaked': [2572], 'dramatically': [2578, 4147], 'nondetectable': [2584], 'h': [2587, 3246, 3623, 3650, 5024, 5040], '1C),': [2589, 3694], 'transduction': [2594, 3671, 3982, 4067], 'cascade': [2595, 3997, 4027], 'initiated': [2596], 'leads': [2599], 'Akt.': [2604, 4248, 5081, 5139], 'addition,': [2606, 2998, 3588], 'made': [2618], 'shorter': [2620], 'duration': [2621], 'compared': [2625, 4453], '(supplementary': [2629, 3054, 3075], 'verify': [2633, 3597], 'activation,': [2641, 2986], 'carried': [2643, 2672], 'out': [2644, 2673], 'mouse': [2648, 2749, 3232], 'C2C12,': [2653], 'and,': [2654], 'activated': [2660, 2933], '2A,': [2664, 3279], 'lanes': [2665], '5).': [2668], 'Further': [2669], 'verification': [2670], 'muscle.': [2677, 5100], 'anesthetization,': [2679], 'perfused': [2682], 'collected': [2691], 'vitro': [2696], '1E': [2702], 'IF).': [2706], 'Similar': [2707], 'lines,': [2716], '1E,': [2727], 'lane': [2728, 3280, 4151, 4154, 4203, 4206], '8).': [2729], 'Together,': [2730, 3664], 'this': [2735, 2766, 3227, 4961], 'physiologically': [2742, 5150], 'lines': [2755, 4847], 'investigated': [2765, 4056, 5156], 'putative': [2767], 'signaling': [2769, 2906, 3536, 3545, 4026], 'pathway': [2770, 4007, 4717], 'detail.': [2773], 'chronic': [2779, 5105], '(19Fediuc': [2787], 'Gaidhu': [2789, 2825], 'M.P.': [2790, 2826], 'Ceddia': [2791, 2839], 'R.B.': [2792, 2840], 'Regulation': [2793, 4266], 'acetyl-CoA': [2799], 'carboxylase': [2800], 'cells.J.': [2807, 2858, 2909], '47:': [2811], '412-431Abstract': [2812], '(89)': [2820], '20Pimenta': [2823], 'A.S.': [2824], 'Habib': [2827], 'So': [2829], 'Fediuc': [2831], 'Mirpourian': [2833], 'Musheev': [2835], 'Curi': [2837], 'Prolonged': [2841], 'impairs': [2845], 'oxidation': [2848], 'despite': [2849], 'Cell.': [2859], 'Physiol.': [2860, 4282], '2008;': [2861], '217:': [2862], '478-562Crossref': [2863], '(47)': [2866], 'able': [2873, 2947], '(21Ouchi': [2878], 'Kobayashi': [2880], 'Kihara': [2882], 'Kumada': [2884], 'Sato': [2886], 'Inoue': [2888], 'Funahashi': [2890], 'Walsh': [2892], 'Adiponectin': [2894], 'angiogenesis': [2896], 'promoting': [2898], 'cross-talk': [2899], 'between': [2900, 3446, 3699, 4128], 'endothelial': [2908, 4030], '1304-1312Abstract': [2914], '(669)': [2922], 'Therefore,': [2925, 4404], 'tested': [2927], 'treatment.': [2936], 'show': [2939], 'short-term': [2941, 3130, 4574, 4839], '(Thr172)': [2952], 'starting': [2953], 'early': [2955], 'reaching': [2960], 'peak': [2962], '1C).': [2976], 'takes': [2980], 'place': [2981], 'it': [2987, 3173, 3751, 3934, 5107, 5132], 'mediate': [2993], 'activation.': [2996, 3480, 3681], '1D).': [3013], 'Besides': [3014], 'plasma-abundant': [3024], 'cells.': [3030, 3762, 4001, 4834], 'linoleic': [3032, 3065], 'stearic': [3037, 3070], 'all': [3039], 'IB,': [3056], 'D).': [3059], 'combination': [3062], 'IE),': [3077], 'ratio': [3080, 3086], 'mimicked': [3081], '(22Yamazaki': [3090], 'Hamazaki': [3092], 'Yano': [3094], 'Funada': [3096], 'Ibuki': [3098], 'F.': [3099], 'Changes': [3100], 'composition': [3104, 3425], 'infusion': [3111], 'docosahexaenoic': [3113], 'ethyl': [3115], 'ester.Am.': [3116], 'Clin.': [3118], 'Nutr.': [3119], '53:': [3121], '620-626Crossref': [3122], '(38)': [3125], 'treatment,': [3131, 3381, 5106], 'besides': [3132], 'stimulated.': [3139], 'Western': [3141, 3726, 3951], 'blot': [3142, 3952], 'p44': [3149], '(Thr202)': [3150], 'p42': [3152], '(Tyr204)': [3153], 'returned': [3160], 'level': [3163, 3845, 4982], '15': [3165], '1F).': [3168], 'stimulation': [3170, 3194], 'implied': [3171], 'might': [3174, 3876, 4944, 5069], 'participate': [3175], 'uptake.': [3178, 3504, 3711, 3888, 3918, 4123], 'Acute': [3179], '(activation': [3188], 'uptake)': [3197], 'indicate': [3198, 3471, 4572, 4763, 4852], 'function': [3202], 'soluble': [3205], 'factor': [3206, 3476], 'order': [3220], 'transduce': [3222], 'signal.': [3224, 4956], 'test': [3226], 'hypothesis,': [3228], 'achieved': [3238], 'incubating': [3240], 'avoid': [3250], 'internalization.': [3252], 'remove': [3261], 'unbound': [3262], 'activate': [3269], 'appeared': [3274], '8),': [3281], 'reached': [3282, 4979], 'maximum': [3284], '(lane': [3288, 3322], '9),': [3289], 'declined': [3291], 'thereafter,': [3292], '37°C.': [3302], 'when': [3304, 3766, 3794, 4974, 5028, 5122], '0.4%': [3305], 'BSA-containing': [3308], 'wash': [3313], 'cells,': [3315, 3723, 4173], '14),': [3323], 'necessary': [3334], 'stimu\xadlation.': [3338], 'conducted': [3340], 'trace': [3345], 'amounts': [3346], 'effective': [3354], 'little': [3360], '0.43%': [3362], 'original': [3365], 'applied': [3369, 3506, 3901], '2B).': [3371], 'investigate': [3373], 'during': [3378], 'majority': [3399], '(79.8%': [3400], '1.1%)': [3402], '2C,': [3418, 3436, 3463], 'group': [3419, 3437, 3464, 3467], '1)': [3420], 'main': [3424], '(62.4%': [3426], '4.6%)': [3428], 'incubation': [3432], '3).': [3438], 'content': [3440], 'significant': [3444, 5084, 5151], 'different': [3445, 4437, 4556], 'BSA': [3450], 'washing,': [3451], 'phospholipids,': [3453], 'monoacylglycerol,': [3454], 'diacylglycerol,': [3455], 'did': [3458, 3662, 4195, 4215], 'change': [3460], 'vs.': [3466, 4153, 4205], '2).': [3468], 'These': [3469, 3869, 4111, 4224], 'above': [3482, 3973, 4985, 5088], 'activity,': [3494, 3776], 'selective': [3509, 3539], '(23Yang': [3512], 'L.': [3513, 4466], 'Dan': [3514], 'H.C.': [3515], 'Sun': [3516, 3520], 'X.M.': [3521], 'Feldman': [3522], 'R.I.': [3523], 'Hamilton': [3524], 'Polokoff': [3526], 'Nicosia': [3528], 'S.V.': [3529], 'Herlyn': [3530], 'al.Akt/protein': [3533], 'inhibitor-2,': [3537], 'small': [3540], 'molecule': [3541], 'antitumor': [3547], 'cancer': [3550], 'overexpressing': [3552], 'Akt.Cancer': [3553], '64:': [3556], '4394-4402Crossref': [3557], '(404)': [3560], 'block': [3564, 3966], 'activity.': [3566], 'abolish': [3572, 3933], '3A)': [3576], '3B).': [3586], 'expression': [3590, 3614, 3637, 3844], 'inhibitor.': [3603], 'duplexes': [3605], 'determined': [3617], '24,': [3619], '48,': [3620], '72': [3622], 'nucleofection.': [3625], 'Compared': [3626], '(N.C.),': [3631], 'efficiently': [3634, 4093], 'downregulate': [3635], '3C).': [3639], '3D': [3642], 'shows,': [3643], 'further': [3645], 'nucleofection,': [3652], 'transfection': [3654, 3661], 'N.C.': [3660, 4181], 'not.': [3663], 'PA-triggered': [3669, 3916], 'induces': [3672], 'via': [3679, 3757, 3993, 4858, 5077], 'sequentially': [3689], 'PA-treated': [3691], 'studied': [3696, 4837], 'relationship': [3698, 4127], 'agonist': [3713], 'AICAR': [3714, 3740], 'blots': [3727], 'only': [3731, 4049, 4973], '4A),': [3747], 'suggests': [3749], 'On': [3763, 5101], 'contrary,': [3765], 'C': [3772, 3780], '4B)': [3787], '4C).': [3792], 'Moreover,': [3793], '(AMPK-DN)': [3800], 'plasmid': [3801], 'AMPK-DN': [3808, 3867, 5198], 'expressed': [3810], '4D),': [3812], '4E)': [3817], '4F)': [3822], 'decreased.': [3825], 'transfected': [3831, 4172], 'catalytic': [3837], 'subunits': [3838], 'α1': [3839], 'α2,': [3841], '\xaddramatically': [3847], 'expected': [3850], '4G),': [3852], 'PA-stimulated': [3854, 3873, 4065, 4115, 4143, 4854], '4H),': [3861], 'experiments.': [3868], 'contribute': [3877, 4119, 5070], 'regulate': [3879], 'upstream': [3892, 4160], 'pathway,': [3899], 'LY294002,': [3902], 'specific': [3904], 'inhibitor,': [3906], 'functions': [3914], 'Unlike': [3919], 'partially': [3925, 4050], 'surprisingly,': [3929], '5A),': [3936], 'played': [3940], 'reduce': [3959], '5B)': [3964], '5C).': [3970], 'indicated': [3975], 'finding': [4003], 'recently': [4011], 'work': [4013], 'Youn': [4015], 'al': [4017], '(24Youn': [4018], 'J.Y.': [4019], 'Cai': [4022], 'ezrin/calpain/PI3K/AMPK/eNOSs1179': [4025], 'mediating': [4028], 'VEGF-dependent': [4029], 'nitric': [4031], 'oxide': [4032], 'production.Circ.': [4033], '2009;': [4035], '104:': [4036], '50-58Crossref': [4037], '(102)': [4040], 'pathways.': [4059], 'MAPK/ERK': [4072, 5222], '(MEK)': [4074], 'PD98056': [4077, 4212], 'U0126.': [4079], 'Both': [4080], 'phosphorylation,': [4088, 4220, 4940, 5116], 'worked': [4091], '5D).': [4095, 4223], 'When': [4096], 'inhibited': [4100], 'U0126,': [4102], '5E).': [4110], 'pathways,': [4132], 'first,': [4133], 'used.': [4138], '5F,': [4150], '6': [4152], '2),': [4155, 4207], 'Second,': [4167], 'α1/α2': [4170], 'normally': [4179], '5G).': [4187], 'Third,': [4188], '5F': [4202], '4': [4204], 'finally,': [4209], 'MEK1/2': [4210], 'either': [4221], 'regulated': [4240], 'independent': [4244], 'meals,': [4250], '(25Campbell': [4258], 'Carlson': [4260], 'M.G.': [4261], 'Hill': [4262], 'Nurjhan': [4264], 'humans:': [4275], 'lipolysis': [4278], 'reesterification.Am.': [4280], '263:': [4284], 'E1063-E1071PubMed': [4285], 'acylation': [4288, 4306], 'stimulating': [4289, 4307], '(26Saleh': [4291], 'Summers': [4293], 'L.K.': [4294], 'Cianflone': [4295], 'Fielding': [4297], 'B.A.': [4298], 'Sniderman': [4299], 'Coordinated': [4303], '(ASP)': [4309], 'triacylglycerol': [4311], 'clearance': [4312], 'vivo': [4318], 'postprandial': [4321, 4424], 'period.J.': [4322], '39:': [4326], '884-974Abstract': [4327], 'factors,': [4338], 'decreasing': [4339], 'h.': [4346], 'Thereafter,': [4347], 'released': [4352], 'source.': [4361], 'quickly': [4368], 'reach': [4371], 'about': [4372, 4828], '400': [4373], 'several': [4376], 'hours': [4377], 'varies': [4412], 'considerably': [4413], 'forms': [4419], 'wave': [4421], 'every': [4423], 'period.': [4425], 'Under': [4426], 'pathological': [4427], 'conditions,': [4428], 'constantly': [4434], 'patterns;': [4438], 'obese': [4441, 4471], 'nondiabetic': [4442], 'humans': [4443], '600–800': [4451], '(27Paquot': [4457], 'Scheen': [4459], 'A.J.': [4460], 'Dirlewanger': [4461], 'Lefebvre': [4463], 'Tappy': [4465], 'Hepatic': [4467], 'non-diabetic': [4472], 'diabetic': [4478], 'patients.Obes.': [4479], '10:': [4482], '129-162Crossref': [4483], '(34)': [4486], 'changing': [4497], 'remains': [4501], 'Many': [4503, 5064], 'revealed': [4506], 'elevation': [4527], 'consist': [4529], 'many': [4531, 4548], 'abnormal': [4532, 5065], 'cycles.': [4535], 'Thus,': [4536, 4991], 'cumulative': [4545], 'elevations': [4552], 'offer': [4554], 'understanding': [4559], 'pathology': [4561], 'diabetes.': [4565], 'previous': [4568], '28Nugent': [4623], 'Prins': [4625], 'J.B.': [4626], 'Whitehead': [4627], 'Wentworth': [4629], 'Chatterjee': [4631], 'V.K.': [4632], "O'Rahilly": [4633], 'Arachidonic': [4635, 4783], '3T3–L1': [4641, 4795], 'increasing': [4644], 'GLUT1': [4645, 4767], 'Evidence': [4653], 'involvement': [4655, 4765], 'lipoxygenase': [4657], 'metabolites': [4658], 'peroxisome': [4660], 'proliferator-activated': [4661], 'receptor': [4662, 4873], 'gamma.J.': [4663], '276:': [4667], '9149-9205Abstract': [4668], '(98)': [4676], '29Hunnicutt': [4679], 'J.W.': [4680], 'Hardy': [4681], 'Williford': [4683], 'Saturated': [4687], 'acid-induced': [4689, 5050], 'adipocytes.Diabetes.': [4694], '1994;': [4695], '43:': [4696], '540-544Crossref': [4697], '(131)': [4700], 'Some': [4703], 'share': [4710], 'part': [4713], 'common': [4716], '(30Fong': [4771], 'J.C.': [4772], 'Chen': [4773], 'C.C.': [4774], 'Chai': [4777], 'S.P.': [4778], 'Tu': [4779], 'M.S.': [4780], 'Chu': [4781], 'K.Y.': [4782], 'intrinsic': [4787], 'ubiquitous': [4790], '(GLUT1)': [4793], 'C-independent': [4801], 'mechanism.Cell.': [4802], 'Signal.': [4803], '1996;': [4804], '8:': [4805], '179-261Crossref': [4806], '(25)': [4809], 'Scholar);': [4811], 'picture': [4814], 'yet': [4821], 'emerged.': [4822], 'More': [4823], 'importantly,': [4824], 'less': [4825], 'known': [4827], 'situation': [4830], 'occurs': [4857], 'lead': [4867], '6).': [4871], 'autophosphorylation': [4874], 'isolated': [4883], 'work,': [4928], 'membrane-bound': [4933], 'indicating': [4941], 'interact': [4945], 'some': [4947], 'protein(s)': [4948, 4962], 'identity': [4959], 'needs': [4964, 5153], 'determined.': [4967], 'certain': [4981], '(at': [4983], 'cells).': [4990], 'concluded': [4993], 'require': [4999], 'high': [5000], 'under': [5005, 5104], 'physiological': [5006], 'situations.': [5007], 'According': [5008], 'results,': [5011], 'detectable': [5015], 'up': [5021], '2A),': [5026], 'withdrawn,': [5032], 'dis\xadappeared': [5037], '(data': [5044], 'shown),': [5046], 'dephosphorylation': [5053], 'completed': [5058], 'one': [5060, 5102], 'cycle.': [5063], 'cycles': [5068], 'desensitization': [5079], 'most': [5083], 'implication': [5085], 'two': [5095], 'opposing': [5096], 'hand,': [5103, 5121], 'insulin-induced': [5110], 'short': [5130, 5236, 5241], 'time,': [5131], 'activating': [5138], 'Yin-Yang': [5141], 'balance': [5142], 'must': [5148], 'further.': [5157], 'authors': [5159, 5175], 'thank': [5160, 5179], 'Drs.': [5161, 5180], 'John': [5162], 'Zehmer': [5163], 'Joy': [5165], 'Fleming': [5166], 'reading': [5170], 'useful': [5172], 'suggestions.': [5173], 'want': [5177], 'Huina': [5181], 'Zhang': [5182, 5185], 'Shuyan': [5184], 'ad\xadministrative': [5188], 'support.': [5189], 'grateful': [5192], 'Carling': [5196], 'construct.': [5199], 'Download': [5200], '.pdf': [5201], '(.31': [5202], 'MB)': [5203], 'Help': [5204], 'pdf': [5206], 'files': [5207], 'phosphor\xadylated': [5232]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2134287536', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 6}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 7}, {'year': 2018, 'cited_by_count': 4}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 6}, {'year': 2014, 'cited_by_count': 14}, {'year': 2013, 'cited_by_count': 4}, {'year': 2012, 'cited_by_count': 6}], 'updated_date': '2024-12-15T02:28:51.695952', 'created_date': '2016-06-24'}
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