Title: Synthesis and biological activity of enantiomers of a conformationally restricted muscarone analog
Abstract: A short and efficient synthesis of both enantiomers of 2,8-dimethyl-1-oxa-8-azaspiro[4.5]-decan-3-one is described. The biological activity of the racemate resides predominantly in the S-enantiomer. While the S-isomer is a full M2-agonist, the R-isomer is devoid of M2 efficacy.
Publication Year: 1995
Publication Date: 1995-08-01
Language: en
Type: article
Indexed In: ['crossref']
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Cited By Count: 6
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