Publication Information

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3000, 3033], 'S.': [35, 146], 'Ananth': [36, 147, 149, 2841], 'Karumanchi': [37, 150, 1621, 1723, 1763, 1795, 1869, 2100, 2275, 2708, 2842, 2945], 'ThadhaniRavi': [40], 'Thadhani': [42, 1713, 1743, 1781, 1855, 2711], 'From': [43, 97, 151], 'the': [44, 98, 152, 210, 277, 285, 305, 312, 318, 322, 325, 333, 337, 342, 375, 397, 414, 429, 434, 446, 474, 554, 562, 565, 575, 584, 600, 620, 624, 674, 705, 711, 714, 719, 741, 765, 777, 800, 812, 885, 910, 938, 960, 964, 980, 1003, 1008, 1082, 1098, 1113, 1162, 1186, 1197, 1209, 1223, 1226, 1231, 1234, 1260, 1267, 1320, 1347, 1351, 1362, 1378, 1382, 1395, 1402, 1408, 1423, 1428, 1433, 1448, 1534, 1572, 1729, 1897, 1904, 2020, 2116, 2330, 2376, 2427, 2807, 2847, 2885, 2888, 3007], 'Departments': [45, 61, 99, 115, 153, 169], 'of': [46, 62, 81, 88, 100, 116, 135, 142, 154, 170, 189, 196, 205, 214, 253, 287, 307, 314, 321, 327, 378, 417, 424, 466, 512, 551, 559, 568, 579, 602, 608, 626, 665, 713, 721, 737, 769, 779, 790, 794, 803, 822, 858, 868, 888, 899, 914, 933, 940, 976, 990, 1002, 1005, 1010, 1094, 1115, 1127, 1136, 1143, 1174, 1188, 1193, 1200, 1225, 1233, 1262, 1270, 1322, 1350, 1377, 1381, 1404, 1412, 1430, 1435, 1450, 1533, 1567, 1731, 1771, 1835, 1899, 1906, 1966, 1986, 2011, 2019, 2022, 2043, 2051, 2118, 2223, 2254, 2326, 2332, 2339, 2370, 2373, 2421, 2424, 2484, 2491, 2528, 2618, 2644, 2695, 2796, 2829, 2850, 2887, 2890, 2916, 2928, 2954, 3009, 3043], 'Medicine': [47, 63, 101, 117, 155, 171], 'Obstetrics': [49, 65, 103, 119, 157, 173], 'Gynecology': [51, 67, 105, 121, 159, 175], '(R.T.),': [52, 106, 160], 'Massachusetts': [53, 107, 161, 1424, 1486], 'General': [54, 108, 162, 1425, 1487], 'Hospital,': [55, 109, 163, 1488], 'Harvard': [56, 74, 110, 128, 164, 182], 'Medical': [57, 72, 75, 111, 126, 129, 165, 180, 183, 1399], 'School,': [58, 76, 112, 130, 166, 184], 'Boston,': [59, 77, 113, 131, 167, 185, 1489], 'Mass;': [60, 78, 114, 132, 168, 186], '(S.A.K.),': [68, 122, 176, 1471], 'Beth': [69, 123, 177, 1396], 'Israel': [70, 124, 178, 1397], 'Deaconess': [71, 125, 179, 1398], 'Center,': [73, 127, 181], 'Division': [80, 134, 188], 'Nephrology': [82, 136, 190], '(R.J.J.),': [83, 137, 191], 'Hypertension': [84, 138, 192, 225, 235, 2496, 2531, 2551, 2714, 2758, 2824, 2891, 3014], 'Transplantation,': [86, 140, 194], 'University': [87, 141, 195], 'Florida,': [89, 143, 197], 'Gainesville.': [90, 144, 198], ',': [91, 2362, 2364, 2380, 2802], 'JohnsonRichard': [94], 'KarumanchiS.': [148], 'Originally': [199, 3063], 'published24': [200], 'Oct': [201], '2005https://doi.org/10.1161/01.HYP.0000188701.24418.64Hypertension.': [202], '2005;46:1250–1251Other': [203], 'version(s)': [204], 'this': [206, 215, 371, 425, 471, 792, 934, 1189, 1280, 1296, 1354, 1366, 1371], 'articleYou': [207], 'are': [208, 487, 873, 1239, 1373, 1678, 2607], 'viewing': [209], 'most': [211], 'recent': [212, 394, 591, 773, 1194, 1357], 'version': [213], 'article.': [216], 'Previous': [217, 222, 2314], 'versions:': [218], 'October': [219], '24,': [220, 3065], '2005:': [221], 'Version': [223], '1': [224, 1496, 1629, 1807], 'during': [226, 689, 2918, 3011], 'pregnancy': [227, 1215, 1573, 2425, 2457, 2687], 'remains': [228, 1337], 'a': [229, 251, 265, 296, 451, 477, 535, 549, 758, 825, 866, 879, 949, 983, 1040, 1084, 1107, 1119, 1157, 1181, 1217, 1286, 1313, 1338, 1387, 1416, 1419, 1894, 1964, 2016, 2291, 2647], 'common': [230], 'potentially': [232, 582], 'devastating': [233], 'complication.1,2': [234], 'can': [236, 248], 'be': [237, 360, 480, 652, 974, 1049, 1245, 1256, 1298], 'isolated': [238, 530], '(gestational': [239], 'hypertension)': [240], 'or': [241, 256, 494, 787, 834, 1380], 'associated': [242, 1132], 'with': [243, 295, 668, 694, 710, 718, 728, 740, 749, 819, 942, 966, 1035, 1118, 1133, 1216, 1222, 1272, 1291, 1333, 1447, 2088, 2611, 2923], 'proteinuria': [244, 917, 1638, 2081], '(preeclampsia)': [245], 'and,': [246], 'rarely,': [247], 'manifest': [249], 'as': [250, 646, 655, 757, 807, 926, 1312, 1893, 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2048, 2082, 2086, 2180, 2213, 2257, 2306, 2329, 2342, 2375, 2426, 2487, 2497, 2525, 2575, 2579, 2609, 2653, 2686, 2718, 2752, 2821, 2861, 3006, 3040], 'which': [290, 453, 1012, 1025, 1101, 1139, 1307, 1327], 'seizures': [291], 'develop': [292, 2262], 'association': [294, 664, 736, 1126], 'high': [297], 'fetal': [300, 751, 1095, 1945, 1967, 2025, 2084], 'maternal': [302, 613, 729, 1076, 1163, 2023, 2214], 'mortality.Although,': [303], 'ideally,': [304], 'diagnosis': [306, 576, 625, 1009, 1321, 1409], 'these': [308, 362, 632], 'conditions': [309], 'should': [310, 1205, 1302], 'involve': [311], 'use': [313, 459, 778, 802], 'biomarkers': [315, 552, 567, 1220], 'that': [316, 448, 455, 476, 525, 896, 937, 1152, 1203, 1279, 1673, 1879], 'reflect': [317], 'underlying': [319, 1348], 'pathophysiology': [320, 601, 1224, 1349, 3008], 'disease': [323], 'process,': [324], 'lack': [326], 'clinically': [328, 636, 921], 'available': [329, 642, 833], 'assays': [330, 630], 'has': [331, 380, 427, 670, 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[386, 853, 1249], 'organizations': [387], 'continue': [388], 'classify': [390], 'differently.3': [392], 'A': [393, 1124, 1901, 1929, 2480, 2613], 'report': [395], 'from': [396, 764, 1304, 2650], 'National': [398, 1497, 1535], 'High': [399, 407, 1498, 1507, 1536, 1544, 1907, 2858], 'Blood': [400, 408, 1499, 1508, 1537, 1545, 1908, 2859], 'Pressure': [401, 409, 1500, 1509, 1538, 1546, 2860], 'Education': [402, 1501, 1539], 'Program': [403, 1502, 1540], 'Working': [404, 1503, 1541], 'Group': [405, 1504, 1542], 'Pregnancy3': [411], 'nicely': [412], 'summarized': [413], 'current': [415, 422], 'status': [416], 'diagnosing': [418], 'preeclampsia:': [419, 2612, 2919], '"Although': [420], 'our': [421, 1300], 'understanding': [423, 2307], 'syndrome': [426, 716, 1574], 'increased,': [428], 'criteria': [430, 486, 913, 1211], 'used': [431, 1317], 'identify': [433], 'disorder': [435], 'remain': [436], 'subject': [437], 'confusion': [439, 443, 472], 'controversy.': [441], 'The': [442, 1984, 2009, 2040, 2207, 2324, 2616, 2642, 2723, 2794], 'doubtless': [444], 'reflects': [445], 'fact': [447, 475], 'syndrome,': [452], 'means': [454], 'attempts': [456, 543], 'at': [457, 493, 841, 952, 2220], 'arbitrarily': [460], 'selected': [461], 'markers': [462, 634], 'rather': [463], 'than': [464, 1589], 'changes': [465], 'pathophysiologic': [467], 'importance."': [468], 'Adding': [469], 'woman': [478], 'delivered': [481], 'well': [482, 528, 685], 'before': [483], 'specific': [484, 609], 'research': [485, 517], 'met,': [488], 'especially': [489, 654], 'if': [490, 1230], 'she': [491], 'near': [495], 'term.': [496], 'Although': [497, 724, 1295], 'certainly': [498], 'appropriate': [499], 'medicine,': [502], 'such': [503, 645, 889, 925], 'practice': [504], 'leads': [505], 'significant': [507], 'misclassification,': [508], 'accurate': [510], 'assessment': [511, 1269], 'phenotypes': [513], 'critical': [515], 'purposes.Indeed,': [518], 'we': [519, 1204, 1308, 1328], 'have': [520, 544, 593, 703, 775, 1031, 1156, 1180], 'known': [521, 672], 'some': [523], 'time': [524], 'extends': [527], 'beyond': [529, 909], 'rise': [536, 698, 706, 1085], 'albumin': [539], 'excretion,4,5': [540], 'been': [545, 671, 1019, 1061, 1131], 'made': [546, 883], 'incorporate': [548, 1259], 'variety': [550], 'into': [553, 875, 1081], 'hopes': [558], 'better': [560], 'refining': [561], 'diagnosis.3': [563], 'Ideally,': [564], 'following': [566], '"pathophysiologic': [569], 'importance"': [570], 'would': [571, 1255, 1277], 'assist': [572], 'greatly': [573], 'management': [578], 'provide': [583, 1039], 'underpinnings': [585], 'targeted': [587], 'therapies.': [588], 'For': [589], 'example,': [590], 'findings': [592], 'implicated': [594], 'altered': [595], 'circulating': [596, 1134, 1172], 'angiogenic': [597, 610, 1405, 1726], 'factors': [598, 1727], 'preeclampsia,6,7': [603], 'detecting': [605], 'an': [606, 733, 808, 1032, 1050, 1092, 1439, 2654], 'imbalance': [607], 'proteins': [611, 1406], 'circulation': [614], 'predict': [619], 'development': [621], 'confirm': [623, 1319], 'preeclampsia.8–12': [627], 'Nonetheless,': [628], 'until': [629], 'bioavailable': [633], 'become': [635], 'available,': [637], 'certain': [638], 'traditional': [639, 911], 'readily': [641], 'laboratory': [643], 'tests,': [644], 'serum': [647, 678, 780, 804, 829, 944, 968, 988, 1015, 1026, 1263, 1833, 1987, 2012, 2044, 2217, 2605], 'uric': [648, 666, 679, 708, 738, 781, 805, 830, 945, 969, 991, 999, 1016, 1027, 1046, 1077, 1087, 1153, 1264, 1310, 1455, 1988, 2013, 2045, 2111, 2218], 'acid,': [649, 1989, 2112, 2284], 'deserve': [650], 'revisited,': [653], 'improved': [656], 'study': [657, 935, 1238], 'designs': [658], 'more': [659, 766, 1182, 1588], 'accurately': [660], 'assess': [661], 'their': [662, 900], 'utility.An': [663], 'acid': [667, 680, 709, 739, 782, 806, 831, 946, 970, 1000, 1017, 1028, 1047, 1058, 1078, 1088, 1154, 1265, 1311, 1456, 2014, 2046, 2076, 2166, 2219], 'since': [673], 'late': [675], '1800s.13': [676], 'Whereas': [677], 'usually': [681], 'falls': [682], 'levels': [684, 696, 947, 971, 989, 1135, 1994, 2606, 2685], 'below': [686], '4': [687], 'mg/dl': [688], 'early-to-middle': [690], 'pregnancy,': [691], 'patients': [693], 'preeclampsia,': [695, 1011, 3012, 3041], 'often': [697], '>4.5': [699], 'mg/dl.14,15': [700], 'Several': [701], 'studies': [702, 774, 1038, 1195, 1358], 'correlated': [704], 'severity': [712, 2021], 'preeclamptic': [715], 'degree': [720], 'glomerular': [722], 'injury.14,15': [723], 'hyperuricemia': [725], 'does': [726], 'correlate': [727], 'morbidity,': [730], 'there': [731, 1147], 'even': [734], 'stronger': [735], 'small': [744, 1108], 'birth': [745], 'weight': [746], 'infants': [747, 1129], 'overall': [750], 'mortality.14,15': [752], 'Nevertheless,': [753], 'whereas': [754], 'once': [755, 1206], 'viewed': [756], 'helpful': [759], 'marker': [760], 'distinguish': [762], 'benign': [767], 'forms': [768], 'gestational': [770, 2089, 2494], 'hypertension,': [771, 859, 1636, 2495, 2689], 'challenged': [776], 'predicting': [784, 1944, 1996], 'its': [788, 1330], 'myriad': [789], 'complications.16–18In': [791], 'issue': [793], 'Hypertension,': [795, 2460, 2761, 2830, 2894, 3045], 'Roberts': [796, 892, 905, 995, 1235, 1557, 1583, 2061], 'et': [797, 893, 906, 996, 1236], 'al19': [798, 907, 997, 1237], 'revisit': [799, 1208], 'aid': [809], 'assessing': [811], 'adverse': [815, 923, 957, 1036, 1334, 2456], 'outcomes': [816], 'among': [817, 1289], 'women': [818, 840, 848, 941, 1271, 1290, 2087, 2259, 2610], 'hypertensive': [820, 1948, 2028, 2049, 2422], 'disorders': [821, 2050, 2423], 'pregnancy.': [823, 1275, 1294, 1949, 2052], 'Using': [824], 'nested': [826], 'case-control': [827, 2614], 'design,': [828], 'was': [832, 835], 'subsequently': [836, 2261], 'measured': [837], '>900': [839], 'admission': [842], 'labor': [844], 'delivery.': [846, 931], 'Importantly,': [847, 904], 'were': [849], 'categorized': [850], '8': [852, 2346], 'groups': [854], 'using': [855], 'various': [856], 'combinations': [857], 'proteinuria,': [860, 978], 'hyperuricemia.': [862], 'It': [863], 'always': [865], 'sacrifice': [867], 'power': [869], 'when': [870], 'outcome': [871, 1968], 'data': [872], 'divided': [874], 'multiple': [876, 1390], 'strata;': [877], 'however,': [878], 'compelling': [880], 'case': [881], 'utility': [887, 2042], 'stratification,': [890], 'al.19': [894], 'acknowledge': [895], 'additional': [897], 'verification': [898], 'results': [901, 1187, 1232], 'needed.': [903], 'move': [908, 1359], 'hypertension': [915, 1213, 1273, 1292, 2917, 3010], 'by': [918, 1394, 1422, 1464], 'focusing': [919], 'relevant': [922], 'outcomes,': [924, 2458], 'small-for-gestational-age': [927], 'infant': [928], 'preterm': [930], 'Results': [932], 'suggest': [936, 1202], 'subset': [939], 'represents': [948], 'unique': [950], 'group': [951, 965], 'significantly': [953], 'outcomes.': [958, 1335], 'Interestingly,': [959], 'imparted': [962], 'independent': [975, 1033, 1051, 1331], 'concomitant': [977], 'follows': [982], 'linear': [984], 'trend': [985], 'according': [986], 'acid.': [992], 'In': [993, 2188], 'short,': [994], 'take': [998], 'out': [1001], 'realm': [1004], '"aiding"': [1006], 'how': [1014], 'traditionally': [1020], 'viewed,3': [1021], 'one': [1023, 1305, 1325], 'link': [1034, 1332], 'outcomes.Recent': [1037], 'potential': [1041, 1158], 'mechanism': [1042], 'explain': [1044], 'factor': [1053, 1669, 1768, 1801], 'small-for-birth-weight': [1055], 'infants.': [1056], 'Uric': [1057, 1891, 2075, 2165, 2283], 'recently': [1060], 'shown': [1062], 'reduce': [1064], 'endothelial': [1065, 1072, 1144, 1176, 1568, 1634, 1667, 2149, 2285, 2924, 3038], 'nitric': [1066, 2177], 'oxide': [1067, 2178], 'bioavailability': [1068], 'inhibit': [1071], 'cell': [1073, 1569, 2174], 'proliferation.20–22': [1074], 'Because': [1075], 'passes': [1079], 'freely': [1080], 'placenta,23': [1083], 'could': [1089], 'lead': [1090, 1103, 1881], 'inhibition': [1093, 1114], 'angiogenesis': [1096, 1843], 'third': [1099], 'trimester,': [1100], 'might': [1102], 'not': [1104, 1374], 'only': [1105], 'infant,': [1109], 'but': [1110], 'also': [1111, 1149], 'kidney': [1116, 2452], 'growth': [1117, 1177, 1668, 1767, 1800, 1837], 'reduction': [1120], 'nephron': [1122, 2113], 'number.20,23': [1123], 'similar': [1125], 'small-birth-weight': [1128], 'asymmetrical': [1137], 'dimethylarginine,': [1138], 'another': [1141], 'inhibitor': [1142], 'function.24': [1145], 'Indeed,': [1146], 'accumulating': [1150], 'evidence': [1151, 1566, 1839], 'contributory': [1159], 'role': [1160, 1403, 1429, 2010], 'phenotype,25': [1164], 'other': [1166, 1356], 'factors,': [1167], 'including': [1168], 'oxidative': [1169], 'stress': [1170], 'inhibitors': [1173], 'vascular': [1175, 2182], 'factor,': [1178], 'dominant': [1183], 'role.26In': [1184], 'conclusion,': [1185], 'article': [1190], 'those': [1192, 1376], 'illuminating': [1196], 'biological': [1198, 1343], 'basis': [1199, 1288], 'again': [1207], 'focus': [1218], 'linked': [1221, 1345], 'disorder.': [1227], 'More': [1228], 'specifically,': [1229], 'verified': [1240], 'prospectively': [1241], 'found': [1243], 'generalizable': [1246], '(eg,': [1247], 'across': [1248], 'ages,': [1250], 'races,': [1251], 'ethnicities),': [1253], 'reasonable': [1257], 'measurement': [1261], 'standard': [1268], 'Some': [1276], 'argue': [1278], 'test': [1281], 'already': [1283], 'performed': [1284], 'regular': [1287], 'true,': [1299], 'approach': [1301], 'shift': [1303], 'view': [1309], 'simple': [1314], 'supportive': [1315, 1342], 'measure': [1316], 'appreciate': [1329], 'begging': [1340], 'measures': [1344], 'disease,': [1352], 'us': [1360], 'right': [1363], 'direction': [1364], 'toward': [1365], 'goal.The': [1367], 'opinions': [1368], 'expressed': [1369], 'editorial': [1372], 'necessarily': [1375], 'editors': [1379], 'American': [1383, 2827, 2926], 'Heart': [1384], 'Association.S.A.K.': [1385], 'co-inventor': 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[2655], 'Pre-eclamptic': [2657], 'Rat': [2658], 'Model,': [2659], 'Phytotherapy': [2660], 'Research,': [2661], '10.1002/ptr.3697,': [2662], '26:9,': [2663], '(1375-1380),': [2664], 'Zaki': [2669], 'El-Banawy': [2671], 'El-Gammal': [2674], 'H': [2675, 2964, 2979], 'Plasma': [2677], 'corin': [2679], 'N-terminal': [2681], 'pro-atrial': [2682], 'natriuretic': [2683], 'peptide': [2684], 'Hypertension:': [2691], 'An': [2692], 'International': [2693], "Women's": [2696, 2865], 'Health,': [2698, 2866], '10.1016/j.preghy.2011.10.001,': [2699], '2:1,': [2700], '(48-52),': [2701], '1-Jan-2012.': [2705], 'R': [2712, 2856], 'Disease': [2717], 'Brenner': [2720], "Rector's": [2722], 'Kidney,': [2724], '10.1016/B978-1-4160-6193-9.10048-X,': [2725], '(1792-1823),': [2726], '.': [2727, 2854, 2973], 'Richards': [2730], 'Dhillon': [2732], 'Weimer': [2734], 'Edholm': [2736], 'Bengten': [2738], 'Wilson': [2740], 'Martin': [2742, 2786], '(2011)': [2747], 'CD4+': [2748], 'T-Helper': [2749], 'Cells': [2750], 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