Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2133950971', 'doi': 'https://doi.org/10.1074/jbc.274.22.15538', 'title': 'Mechanism of Interaction of Acanthamoeba Actophorin (ADF/Cofilin) with Actin Filaments', 'display_name': 'Mechanism of Interaction of Acanthamoeba Actophorin (ADF/Cofilin) with Actin Filaments', 'publication_year': 1999, 'publication_date': '1999-05-01', 'ids': {'openalex': 'https://openalex.org/W2133950971', 'doi': 'https://doi.org/10.1074/jbc.274.22.15538', 'mag': '2133950971', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/10336448'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.274.22.15538', 'pdf_url': 'http://www.jbc.org/article/S0021925819730579/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925819730579/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5061615379', 'display_name': 'Laurent Blanchoin', 'orcid': 'https://orcid.org/0000-0001-8146-9254'}, 'institutions': [{'id': 'https://openalex.org/I1307098950', 'display_name': 'Salk Institute for Biological Studies', 'ror': 'https://ror.org/03xez1567', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1307098950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Laurent Blanchoin', 'raw_affiliation_strings': ['From the Structural Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037'], 'affiliations': [{'raw_affiliation_string': 'From the Structural Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037', 'institution_ids': ['https://openalex.org/I1307098950']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5043478405', 'display_name': 'Thomas D. Pollard', 'orcid': 'https://orcid.org/0000-0002-1785-2969'}, 'institutions': [{'id': 'https://openalex.org/I1307098950', 'display_name': 'Salk Institute for Biological Studies', 'ror': 'https://ror.org/03xez1567', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I1307098950']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Thomas D. Pollard', 'raw_affiliation_strings': ['From the Structural Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037'], 'affiliations': [{'raw_affiliation_string': 'From the Structural Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037', 'institution_ids': ['https://openalex.org/I1307098950']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'apc_paid': {'value': 2500, 'currency': 'USD', 'value_usd': 2500, 'provenance': 'doaj'}, 'fwci': 4.639, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 319, 'citation_normalized_percentile': {'value': 0.999781, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '274', 'issue': '22', 'first_page': '15538', 'last_page': '15546'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10379', 'display_name': 'Cellular Mechanics and Interactions', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10379', 'display_name': 'Cellular Mechanics and Interactions', 'score': 0.9971, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12286', 'display_name': 'Erythrocyte Function and Pathophysiology', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12094', 'display_name': 'Hemoglobin structure and function', 'score': 0.993, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/treadmilling', 'display_name': 'Treadmilling', 'score': 0.7492517}, {'id': 'https://openalex.org/keywords/cofilin', 'display_name': 'Cofilin', 'score': 0.62067187}, {'id': 'https://openalex.org/keywords/actin-remodeling', 'display_name': 'Actin remodeling', 'score': 0.5684965}, {'id': 'https://openalex.org/keywords/mdia1', 'display_name': 'MDia1', 'score': 0.52814364}, {'id': 'https://openalex.org/keywords/actin-binding-protein', 'display_name': 'Actin-binding protein', 'score': 0.4775525}], 'concepts': [{'id': 'https://openalex.org/C205309164', 'wikidata': 'https://www.wikidata.org/wiki/Q201389', 'display_name': 'Treadmilling', 'level': 5, 'score': 0.7492517}, {'id': 'https://openalex.org/C125705527', 'wikidata': 'https://www.wikidata.org/wiki/Q185269', 'display_name': 'Actin', 'level': 2, 'score': 0.6247703}, {'id': 'https://openalex.org/C2776601116', 'wikidata': 'https://www.wikidata.org/wiki/Q24786722', 'display_name': 'Cofilin', 'level': 5, 'score': 0.62067187}, {'id': 'https://openalex.org/C3620293', 'wikidata': 'https://www.wikidata.org/wiki/Q14908027', 'display_name': 'Actin remodeling', 'level': 5, 'score': 0.5684965}, {'id': 'https://openalex.org/C59999672', 'wikidata': 'https://www.wikidata.org/wiki/Q21497084', 'display_name': 'MDia1', 'level': 5, 'score': 0.52814364}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.52022666}, {'id': 'https://openalex.org/C189040839', 'wikidata': 'https://www.wikidata.org/wiki/Q329638', 'display_name': 'Microfilament', 'level': 4, 'score': 0.516248}, {'id': 'https://openalex.org/C14228908', 'wikidata': 'https://www.wikidata.org/wiki/Q2920483', 'display_name': 'Protein filament', 'level': 2, 'score': 0.507583}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.4945967}, {'id': 'https://openalex.org/C130861313', 'wikidata': 'https://www.wikidata.org/wiki/Q3775363', 'display_name': 'Actin-binding protein', 'level': 5, 'score': 0.4775525}, {'id': 'https://openalex.org/C2779959927', 'wikidata': 'https://www.wikidata.org/wiki/Q1048687', 'display_name': 'Skeletal muscle', 'level': 2, 'score': 0.43319944}, {'id': 'https://openalex.org/C142669718', 'wikidata': 'https://www.wikidata.org/wiki/Q154626', 'display_name': 'Cytoskeleton', 'level': 3, 'score': 0.33999324}, {'id': 'https://openalex.org/C2993400109', 'wikidata': 'https://www.wikidata.org/wiki/Q329638', 'display_name': 'Actin cytoskeleton', 'level': 4, 'score': 0.30876192}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.30207455}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.28706175}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.10626671}, {'id': 'https://openalex.org/C105702510', 'wikidata': 'https://www.wikidata.org/wiki/Q514', 'display_name': 'Anatomy', 'level': 1, 'score': 0.09719992}], 'mesh': [{'descriptor_ui': 'D000048', 'descriptor_name': 'Acanthamoeba', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000199', 'descriptor_name': 'Actins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D008840', 'descriptor_name': 'Microfilament Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D015800', 'descriptor_name': 'Protozoan Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000048', 'descriptor_name': 'Acanthamoeba', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051339', 'descriptor_name': 'Actin Depolymerizing Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000199', 'descriptor_name': 'Actins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001608', 'descriptor_name': 'Beryllium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001608', 'descriptor_name': 'Beryllium', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D005454', 'descriptor_name': 'Fluorescence Polarization', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005459', 'descriptor_name': 'Fluorides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005459', 'descriptor_name': 'Fluorides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D007700', 'descriptor_name': 'Kinetics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008840', 'descriptor_name': 'Microfilament Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018482', 'descriptor_name': 'Muscle, Skeletal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018482', 'descriptor_name': 'Muscle, Skeletal', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010710', 'descriptor_name': 'Phosphates', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010710', 'descriptor_name': 'Phosphates', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011485', 'descriptor_name': 'Protein Binding', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D015800', 'descriptor_name': 'Protozoan Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011721', 'descriptor_name': 'Pyrenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011817', 'descriptor_name': 'Rabbits', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012235', 'descriptor_name': 'Rhodamines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.274.22.15538', 'pdf_url': 'http://www.jbc.org/article/S0021925819730579/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/10336448', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.274.22.15538', 'pdf_url': 'http://www.jbc.org/article/S0021925819730579/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 52, 'referenced_works': ['https://openalex.org/W1484094963', 'https://openalex.org/W1488840584', 'https://openalex.org/W1501356835', 'https://openalex.org/W1514817439', 'https://openalex.org/W1520440482', 'https://openalex.org/W1538692246', 'https://openalex.org/W1539622248', 'https://openalex.org/W1599563939', 'https://openalex.org/W1640813462', 'https://openalex.org/W1690546964', 'https://openalex.org/W1910757612', 'https://openalex.org/W1928767952', 'https://openalex.org/W1968289383', 'https://openalex.org/W1971256750', 'https://openalex.org/W1975244918', 'https://openalex.org/W1984030342', 'https://openalex.org/W1984234802', 'https://openalex.org/W1986367699', 'https://openalex.org/W1988281791', 'https://openalex.org/W1989642116', 'https://openalex.org/W1994023089', 'https://openalex.org/W1995473877', 'https://openalex.org/W1995517865', 'https://openalex.org/W1996002116', 'https://openalex.org/W1998138428', 'https://openalex.org/W1999350913', 'https://openalex.org/W2009606782', 'https://openalex.org/W2020081859', 'https://openalex.org/W2029584311', 'https://openalex.org/W2032279060', 'https://openalex.org/W2037611941', 'https://openalex.org/W2039723960', 'https://openalex.org/W2039727443', 'https://openalex.org/W2040964473', 'https://openalex.org/W2045923054', 'https://openalex.org/W2052130012', 'https://openalex.org/W2056485052', 'https://openalex.org/W2063796339', 'https://openalex.org/W2069640228', 'https://openalex.org/W2074618456', 'https://openalex.org/W2076481880', 'https://openalex.org/W2082971375', 'https://openalex.org/W2084188731', 'https://openalex.org/W2091289978', 'https://openalex.org/W2103446130', 'https://openalex.org/W2113395636', 'https://openalex.org/W2122782850', 'https://openalex.org/W2125510211', 'https://openalex.org/W2151063801', 'https://openalex.org/W2169045417', 'https://openalex.org/W2171956751', 'https://openalex.org/W4297917728'], 'related_works': ['https://openalex.org/W3003751606', 'https://openalex.org/W2125927252', 'https://openalex.org/W2100455753', 'https://openalex.org/W2084958568', 'https://openalex.org/W2083590644', 'https://openalex.org/W2011545163', 'https://openalex.org/W2011017870', 'https://openalex.org/W1998352165', 'https://openalex.org/W1977669212', 'https://openalex.org/W113641295'], 'abstract_inverted_index': {'We': [0, 199, 2016, 2077, 2399, 4011, 4098], 'characterized': [1, 200], 'the': [2, 47, 61, 123, 138, 148, 184, 201, 246, 260, 322, 337, 347, 383, 410, 463, 467, 471, 477, 571, 585, 632, 771, 1092, 1181, 1205, 1224, 1228, 1253, 1276, 1281, 1300, 1304, 1343, 1350, 1361, 1372, 1433, 1444, 1475, 1485, 1888, 1941, 2018, 2028, 2080, 2116, 2183, 2217, 2241, 2244, 2249, 2260, 2273, 2287, 2296, 2305, 2311, 2316, 2323, 2353, 2358, 2365, 2375, 2382, 2392, 2397, 2420, 2599, 2621, 2662, 2732, 2819, 2853, 2856, 2914, 2984, 2993, 3001, 3007, 3021, 3048, 3061, 3074, 3087, 3091, 3139, 3157, 3176, 3193, 3197, 3201, 3218, 3265, 3271, 3307, 3329, 3344, 3354, 3358, 3377, 3426, 3429, 3463, 3478, 3485, 3488, 3493, 3496, 3506, 3509, 3516, 3523, 3535, 3560, 3612, 3635, 3644, 3669, 3676, 3682, 3694, 3698, 3703, 3731, 3766, 3793, 3817, 3831, 3851, 3909, 3967, 3991, 4035, 4103, 4110, 4116, 4121, 4138, 4155, 4160, 4205, 4237, 4241, 4260, 4267, 4273, 4293, 4298, 4308, 4312, 4363, 4366, 4369, 4372, 4379, 4392, 4398, 4403, 4456, 4462], 'interaction': [3, 139, 202, 338, 1229, 1282, 3092, 3564], 'ofAcanthamoeba': [4, 203], 'actophorin,': [5, 204, 1220, 2379, 2439], 'a': [6, 92, 108, 205, 291, 307, 489, 538, 1221, 1236, 1256, 1384, 1426, 1456, 1745, 1980, 2004, 2144, 2178, 2210, 2595, 2949, 2969, 3031, 3038, 3164, 3364, 3473, 3771, 3783, 3811, 3846, 3921, 3934, 3952, 4004, 4038, 4063, 4152, 4174, 4282, 4327, 4337, 4343], 'member': [7, 206, 1222], 'of': [8, 13, 125, 137, 140, 147, 150, 155, 170, 190, 207, 212, 324, 336, 339, 346, 349, 354, 369, 389, 413, 446, 450, 458, 466, 474, 480, 488, 491, 541, 584, 593, 634, 757, 773, 933, 1057, 1183, 1199, 1207, 1223, 1230, 1238, 1258, 1280, 1283, 1299, 1345, 1353, 1363, 1377, 1435, 1446, 1465, 1747, 1795, 1804, 1816, 1879, 1932, 2030, 2035, 2041, 2087, 2104, 2113, 2138, 2243, 2251, 2266, 2276, 2307, 2313, 2325, 2360, 2367, 2378, 2385, 2396, 2423, 2425, 2431, 2661, 2735, 2741, 2747, 2777, 2821, 2855, 2861, 2878, 2917, 2943, 2971, 2979, 2986, 3003, 3020, 3023, 3041, 3047, 3050, 3068, 3082, 3086, 3090, 3093, 3099, 3138, 3189, 3196, 3203, 3217, 3220, 3234, 3237, 3243, 3262, 3270, 3292, 3300, 3328, 3346, 3353, 3360, 3374, 3428, 3433, 3465, 3487, 3495, 3498, 3508, 3518, 3542, 3559, 3563, 3565, 3572, 3611, 3618, 3626, 3643, 3650, 3658, 3690, 3693, 3700, 3705, 3754, 3759, 3776, 3800, 3803, 3806, 3819, 3853, 3902, 3908, 3914, 3928, 3940, 3947, 3955, 4026, 4041, 4047, 4049, 4065, 4105, 4107, 4128, 4148, 4162, 4177, 4218, 4243, 4269, 4275, 4311, 4314, 4317, 4336, 4360, 4365, 4371, 4394, 4423, 4458, 4466, 4479], 'ADF/cofilin': [9, 208, 586, 761, 918, 1225, 1231, 1285, 2435, 2779, 3460], 'family,': [10, 209], 'with': [11, 142, 210, 341, 402, 1233, 1241, 1287, 1594, 1626, 1749, 1881, 1892, 1934, 1946, 1979, 2003, 2090, 2143, 2202, 2335, 2346, 2427, 2434, 2940, 3037, 3096, 3149, 3228, 3253, 3282, 3338, 3569, 3623, 3655, 3716, 3756, 3808, 3920, 4037, 4137, 4145, 4173, 4223, 4300, 4320, 4386], 'filaments': [12, 30, 39, 90, 101, 106, 117, 130, 143, 182, 191, 211, 229, 238, 289, 300, 305, 316, 329, 342, 381, 390, 436, 493, 572, 636, 923, 1191, 1391, 1414, 1454, 1473, 1835, 1884, 1937, 1997, 2208, 2268, 2433, 2823, 2946, 3225, 3239, 3258, 3341, 3347, 3376, 3440, 3453, 3568, 3622, 3654, 3761, 3830, 3855, 3917, 4016, 4055, 4061, 4150, 4226, 4233, 4256, 4302, 4323, 4389, 4428, 4468], 'amoeba': [14, 37, 52, 88, 213, 236, 251, 287, 1393, 1403, 3713, 3961, 4183, 4224, 4254], 'and': [15, 51, 65, 85, 162, 196, 214, 250, 264, 284, 361, 395, 420, 460, 462, 614, 690, 785, 1073, 1096, 1202, 1244, 1290, 1332, 1339, 1348, 1355, 1374, 1421, 1458, 1526, 1562, 1631, 1694, 1799, 1807, 1897, 1951, 1995, 2022, 2108, 2121, 2127, 2160, 2180, 2230, 2302, 2388, 2659, 2738, 2772, 2885, 2932, 2977, 3080, 3128, 3182, 3240, 3250, 3313, 3513, 3515, 3540, 3555, 3602, 3631, 3665, 3715, 3778, 3789, 3825, 3977, 4017, 4167, 4188, 4246, 4266, 4290, 4368], 'rabbit': [16, 215, 1657, 3436], 'skeletal': [17, 216, 1658, 3437], 'muscle': [18, 28, 50, 99, 217, 227, 249, 298, 421, 431, 1189, 1291, 1389, 1398, 1659, 3212, 3223, 3285, 3438, 3709, 3722, 3965, 3998, 4114, 4194, 4231, 4321, 4426], 'actin.': [19, 218, 429, 3430, 3723], 'The': [20, 134, 166, 219, 333, 365, 1461, 2164, 2190, 2263, 2876, 2957, 2975, 2989, 3027, 3154, 3326, 3416, 3431, 3724, 3734, 3945, 4030, 4169, 4199, 4288, 4352, 4490], 'affinity': [21, 48, 169, 220, 247, 368, 1387, 1464, 3432], 'is': [22, 60, 102, 157, 221, 259, 301, 356, 483, 759, 1274, 1406, 2254, 2286, 2295, 2304, 2352, 2357, 2364, 2374, 2381, 2391, 2440, 2750, 2773, 2814, 2849, 2881, 2924, 2960, 2999, 3030, 3059, 3064, 3175, 3379, 3446, 3470, 3764, 3835, 3971, 3979, 4124, 4429], 'about': [23, 222, 2751, 2925], '10': [24, 223, 1609, 1824, 1826, 3107, 3579], 'times': [25, 224], 'higher': [26, 168, 225, 367, 1386, 1463, 2753, 3381, 3448], 'for': [27, 49, 172, 187, 226, 248, 371, 386, 408, 437, 1303, 1335, 1342, 1349, 1388, 1428, 1443, 1467, 1471, 1859, 2000, 2209, 2992, 3192, 3247, 3412, 3435, 3450, 3958, 3994, 4182, 4193, 4281, 4397], 'actin': [29, 38, 89, 100, 129, 228, 237, 288, 299, 328, 435, 454, 492, 580, 594, 635, 767, 922, 1190, 1234, 1242, 1245, 1289, 1292, 1367, 1380, 1390, 1394, 1399, 1404, 1453, 1806, 1883, 1936, 1996, 2036, 2096, 2173, 2207, 2226, 2267, 2308, 2327, 2371, 2386, 2428, 2432, 2737, 2749, 2755, 2865, 2874, 2891, 2922, 2945, 2987, 3051, 3071, 3101, 3230, 3257, 3340, 3362, 3375, 3386, 3414, 3439, 3452, 3489, 3502, 3567, 3821, 3854, 3905, 3916, 3962, 3999, 4028, 4051, 4054, 4060, 4184, 4195, 4245, 4427, 4467], '(K': [31, 40, 55, 175, 230, 239, 254, 374, 3441, 3454], 'd': [32, 41, 56, 176, 231, 240, 255, 375, 2390, 3442, 3455, 3954, 4118], '=': [33, 42, 57, 80, 177, 232, 241, 256, 279, 376, 3443, 3456], '0.5': [34, 233, 1736, 3125, 3599], 'μm)': [35, 44, 59, 179, 234, 243, 258, 378, 3445], 'than': [36, 132, 180, 235, 331, 379, 578, 1392, 1470, 2257, 2754, 2870, 3382, 3410, 3449, 4210], '5': [43, 242, 1850, 2231, 3150, 3248], 'even': [45, 244, 4250], 'though': [46, 245], 'Mg-ADP-actin': [53, 173, 252, 372], 'monomers': [54, 174, 253, 373, 459, 1243, 1469, 2084, 2089, 2097, 2120, 2234, 2756, 3387], '0.1': [58, 178, 257, 377, 1733, 1844], 'same': [62, 261, 3008, 4294], '(Blanchoin,': [63, 262], 'L.,': [64, 263], 'Pollard,': [66, 265, 2935], 'T.': [67, 266, 1754, 2758, 2933], 'D.': [68, 267, 649, 657, 702, 710, 1107, 1115, 1130, 1138, 1158, 1162, 1911, 1919, 2527, 2535, 2568, 2576, 2673, 2681, 2696, 2704, 2792, 2800, 2934, 3871, 3879, 4071, 4079], '(1998)': [69, 268], 'J.': [70, 269, 518, 520, 545, 645, 658, 670, 679, 698, 711, 731, 742, 810, 829, 845, 870, 945, 967, 987, 1007, 1025, 1045, 1061, 1079, 1103, 1116, 1141, 1163, 1314, 1534, 1580, 1637, 1666, 1683, 1758, 1776, 1866, 1907, 1920, 1960, 2473, 2523, 2536, 2555, 2579, 2609, 2629, 2649, 2669, 2682, 2707, 2762, 2788, 2801, 2897, 3392, 3867, 3880, 4082, 4440], 'Biol.': [71, 270, 547, 604, 620, 660, 681, 713, 797, 812, 847, 871, 947, 968, 1008, 1027, 1118, 1142, 1164, 1315, 1535, 1638, 1667, 1685, 1778, 1867, 1922, 1961, 2475, 2538, 2580, 2611, 2631, 2684, 2708, 2803, 2898, 3393, 3882, 4083, 4442], 'Chem.': [72, 271, 872, 969, 1009, 1143, 1165, 1316, 1536, 1639, 1668, 1868, 1962, 2457, 2581, 2709, 2899, 3394, 4084], '273,': [73, 272], '25106–25111).': [74, 273], 'Actophorin': [75, 104, 121, 274, 303, 320, 1382, 1622], 'binds': [76, 275], 'slowly': [77, 276, 4158], '(k': [78, 277, 3969], '+': [79, 278, 2285], '0.03': [81, 280, 3004], 'μm−1': [82, 281, 2292, 3005, 3932, 3975], 's−1)': [83, 282], 'to': [84, 98, 115, 283, 297, 314, 485, 573, 590, 928, 1251, 1268, 1366, 1379, 1397, 1412, 1479, 1565, 1600, 1744, 2026, 2187, 2222, 2237, 2279, 2322, 2333, 2370, 2418, 2852, 2863, 2872, 2889, 2968, 3014, 3066, 3070, 3259, 3385, 3501, 3637, 3671, 3730, 3770, 3792, 3816, 3897, 3900, 3904, 3984, 4014, 4101, 4240, 4349, 4384, 4425, 4460, 4477], 'dissociates': [86, 285], 'from': [87, 128, 286, 327, 428, 776, 1484, 1656, 1679, 2182, 2240, 2259, 2272, 2964, 3078, 3222, 3264, 3421, 3472, 3531, 3547, 3634, 3668, 3741, 3997, 4058, 4109, 4120, 4133, 4140], 'in': [91, 107, 290, 306, 400, 637, 790, 1264, 1455, 1550, 1597, 1608, 1722, 1843, 1890, 1943, 2039, 2132, 2166, 2195, 2227, 2598, 2845, 2948, 2952, 2996, 3000, 3035, 3141, 3161, 3184, 3273, 3290, 3298, 3315, 3332, 3522, 3534, 3614, 3646, 3762, 3797, 3814, 3839, 3895, 4159, 4251, 4347, 4375, 4400], 'simple': [93, 292, 3474, 4283], 'bimolecular': [94, 293, 3475, 4284], 'reaction,': [95, 294, 3476, 4484], 'but': [96, 295, 1401, 3408, 3545, 4469], 'binding': [97, 296, 1337, 1376, 2448, 2776, 2860, 2871, 3067, 3543, 3901, 3960, 4422, 4480], 'cooperative.': [103, 302, 1407, 4430], 'severs': [105, 304, 1452], 'concentration-dependent': [109, 308], 'fashion.': [110, 309], 'Phosphate': [111, 310, 1408], 'or': [112, 152, 311, 351, 778, 781, 1185, 1409, 1678, 1999, 2038, 2043, 2833, 3520, 4230, 4481, 4488], 'BeF3': [113, 312, 1410], 'bound': [114, 313, 1365, 1411, 2369, 2888, 3384, 3500, 4012], 'ADP-actin': [116, 181, 315, 380, 1340, 1413, 1468, 1472], 'inhibit': [118, 317], 'actophorin': [119, 141, 171, 318, 340, 370, 1336, 1354, 1378, 1416, 1431, 1451, 1466, 1880, 1994, 2042, 2199, 2368, 2426, 2782, 2816, 2880, 3095, 3148, 3221, 3244, 3263, 3281, 3434, 3739, 3755, 3807, 3903, 3959, 3995, 4013, 4108, 4220, 4276, 4319, 4380, 4407, 4424, 4459], 'binding.': [120, 165, 319, 364, 1429], 'increases': [122, 321, 1432, 2867], 'rate': [124, 323, 772, 1333, 1434, 2250, 2275, 2289, 2298, 2318, 2976, 2990, 3039, 3847, 3911, 3924, 3937, 3949, 3992, 4039, 4064, 4104, 4122, 4175, 4295, 4370], 'phosphate': [126, 325, 1422, 1436, 2031, 2128, 2188, 4454], 'release': [127, 326, 1437, 2029, 2129], 'more': [131, 330, 576, 926, 2869, 3011], '10-fold.': [133, 332], 'time': [135, 334, 539, 2212, 2421, 3088, 3136, 3166, 3215, 3268, 3561, 3609, 3641, 3678, 4261, 4309], 'course': [136, 335, 2422, 3089, 3137, 3216, 3269, 3562, 3610, 3642, 4310], 'measured': [144, 343, 3010], 'by': [145, 344, 765, 769, 782, 924, 1196, 1699, 1770, 1793, 1814, 1838, 1887, 1940, 1992, 2085, 2102, 2172, 2442, 2775, 2824, 3018, 3226, 3782, 3987, 4022, 4342], 'quenching': [146, 345, 3019], 'fluorescence': [149, 153, 348, 352, 1074, 1891, 1944, 2730, 2733, 2739, 2746, 2820, 2953, 2997, 3022, 3142, 3162, 3198, 3274, 3333, 3464, 3615, 3647, 3695, 3767, 3798, 3815, 3840, 3896, 4032, 4141, 4156, 4170, 4200, 4238, 4348, 4376], 'pyrenyl-actin': [151, 350, 2233, 2822, 3024, 3204, 3209, 3213, 3224, 3238, 3266, 3286, 3466, 3760, 3809, 3829, 4015, 4111, 4149, 4225, 4232, 4255, 4322, 4388], 'anisotropy': [154, 353, 1945, 2359, 2366, 2740, 2848, 2868, 2877, 2916, 2954, 2998, 3036, 3334, 3378, 3799], 'rhodamine-actophorin': [156, 355, 2862, 2939, 3069, 3337, 3383], 'complicated,': [158, 357], 'because': [159, 358, 629, 1297], 'severing,': [160, 359, 3553], 'depolymerization,': [161, 360, 3554], 'repolymerization': [163, 362], 'follows': [164, 363], '50-fold': [167, 366], 'provides': [183, 382, 1474], 'thermodynamic': [185, 384], 'basis': [186, 385], 'driving': [188, 387], 'disassembly': [189, 388], 'that': [192, 391, 534, 917, 1180, 1260, 1450, 2815, 3060, 3367, 3549, 3775, 3848, 4421, 4452], 'have': [193, 392, 1215], 'hydrolyzed': [194, 393], 'ATP': [195, 394, 1419, 1439, 3499, 3519, 3763, 4163, 4211], 'dissociated': [197, 396], 'γ-phosphate.': [198, 397], 'Actin': [398, 1653, 1739, 1811, 2125], 'filaments,': [399, 461, 768, 1246, 1293, 1400, 1405, 2372, 2387, 3072, 4000], 'conjunction': [401], 'other': [403, 1093], 'cytoskeletal': [404], 'proteins,': [405, 2436, 2780], 'are': [406, 588, 3170, 3306, 3681, 3727, 3918], 'responsible': [407], 'maintaining': [409], 'structural': [411, 2596], 'integrity': [412], 'eukaryotic': [414], 'cells.': [415], 'Phagocytosis,': [416], 'cytokinesis,': [417], 'cell': [418], 'motility,': [419], 'contraction': [422, 432], 'all': [423, 1598], 'depend': [424, 2982, 3480, 4377], 'on': [425, 537, 1188, 1360, 1742, 1791, 2100, 2920, 2983, 3163, 3200, 3343, 3425, 3481, 3697, 3850, 4272, 4378, 4406], 'structures': [426], 'assembled': [427], 'Although': [430], 'requires': [433, 570], 'stable': [434], 'force': [438], 'generation,': [439], 'much': [440, 575, 1385, 2255], 'actin-based': [441], 'motility': [442], 'involves': [443, 1235], 'active': [444], 'turnover': [445], 'filaments.': [447, 1208, 1381, 1395, 2245, 2262, 2328, 2429, 2988, 3052, 3102, 3153, 3231, 3467, 3906, 3963, 4029, 4052, 4112], 'A': [448, 754, 2812, 3232, 3351, 3788, 3824, 4166], 'variety': [449], 'actin-binding': [451], 'proteins': [452, 482, 762, 920, 1232, 3461], 'influence': [453], 'polymerization,': [455], 'steady-state': [456], 'dynamics': [457, 633], 'three-dimensional': [464], 'organization': [465], 'filamentous': [468, 3361], 'meshwork.': [469], 'At': [470, 3371], 'leading': [472], 'edge': [473], 'motile': [475], 'cells,': [476], 'Arp2/3': [478], 'complex': [479, 2082, 2118], 'actin-related': [481], 'thought': [484, 589], 'initiate': [486, 2238, 3260], 'polymerization': [487, 1059, 1344, 2034, 2174, 2253, 2277], 'network': [490], '(1Mullins': [494], 'R.D.': [495], 'Heuser': [496], 'J.A.': [497, 557, 959, 999, 1663], 'Pollard': [498, 843, 943, 965, 1005, 1023, 1312, 1532, 1583, 1635, 1705, 1958, 2471, 2627, 2895, 3390, 4438], 'T.D.': [499, 844, 944, 966, 1006, 1024, 1313, 1533, 1584, 1636, 1682, 1706, 1775, 1959, 2472, 2628, 2896, 3391, 4439], 'Proc.': [500, 2047], 'Natl.': [501, 2048], 'Acad.': [502, 2049], 'Sci.': [503, 2050], 'U.': [504, 2051], 'S.': [505, 727, 824, 865, 983, 1041, 1570, 1665, 1704, 2052, 2065, 2551, 2645], 'A.': [506, 600, 904, 2053, 2403, 2506, 2602, 2608], '1998;': [507, 526, 621, 733, 746, 798, 989, 1047, 1065, 1083, 1144, 1166, 1317, 1537, 1640, 1963, 2557, 2582, 2651, 2710, 2900, 3395, 4085], '95:': [508, 832], '6181-6186Crossref': [509], 'PubMed': [510, 529, 551, 564, 609, 624, 664, 685, 717, 736, 749, 801, 816, 834, 851, 879, 894, 911, 951, 976, 992, 1016, 1031, 1050, 1068, 1086, 1122, 1152, 1174, 1325, 1545, 1589, 1648, 1675, 1689, 1714, 1763, 1782, 1875, 1926, 1971, 2057, 2072, 2413, 2464, 2479, 2496, 2513, 2542, 2560, 2590, 2615, 2635, 2654, 2688, 2718, 2767, 2807, 2908, 3403, 3886, 4093, 4446], 'Scopus': [511, 530, 552, 565, 610, 625, 665, 686, 718, 737, 750, 802, 817, 835, 852, 895, 912, 952, 993, 1032, 1051, 1069, 1087, 1123, 1153, 1175, 1326, 1546, 1590, 1649, 1690, 1715, 1764, 1783, 1927, 1972, 2058, 2073, 2414, 2480, 2497, 2514, 2543, 2561, 2591, 2616, 2636, 2655, 2689, 2719, 2768, 2808, 2909, 3404, 3887, 4094, 4447], '(1046)': [512], 'Google': [513, 532, 554, 567, 612, 627, 667, 688, 720, 739, 752, 804, 819, 837, 854, 880, 897, 914, 954, 977, 995, 1017, 1034, 1053, 1071, 1089, 1125, 1155, 1177, 1328, 1548, 1592, 1651, 1676, 1692, 1717, 1766, 1785, 1876, 1929, 1974, 2060, 2075, 2416, 2465, 2482, 2499, 2516, 2545, 2563, 2593, 2618, 2638, 2657, 2691, 2721, 2770, 2810, 2911, 3406, 3889, 4096, 4449], 'Scholar,': [514, 555, 668, 721, 740, 820, 838, 855, 881, 898, 1018, 1035, 1126, 1156, 2061, 2466, 2483, 2500, 2517, 2564, 2639, 2692], '2Welch': [515], 'M.D.': [516], 'Rosenblatt': [517], 'Skoble': [519], 'Portnoy': [521], 'D.A.': [522, 1578], 'Mitchison': [523, 558, 677], 'T.J.': [524, 559, 678], 'Science.': [525], '281:': [527], '105-108Crossref': [528], '(421)': [531], 'Scholar)': [533, 689, 915, 1178, 1329, 1549, 1593, 1677, 1718, 2417, 2771, 3407, 4450], 'turn': [535], 'over': [536, 2115], 'scale': [540], 'minutes': [542], '(3Wang': [543], 'Y.': [544, 653, 706, 1111, 1134, 1915, 2531, 2572, 2677, 2700, 2796, 3875, 4075], 'Cell': [546, 659, 680, 712, 796, 811, 846, 946, 1026, 1117, 1684, 1777, 1921, 2474, 2537, 2610, 2630, 2683, 2802, 3881, 4441], '1985;': [548, 2458], '101:': [549], '597-602Crossref': [550], '(456)': [553], '4Theriot': [556], 'Nature.': [560], '1991;': [561, 848, 948, 1028, 2476, 2632, 4443], '352:': [562], '126-131Crossref': [563], '(653)': [566], 'Scholar).': [568, 753, 805, 1090, 1652, 1786, 1877, 1930, 1975, 2076, 2722, 2811, 4097], 'This': [569], 'depolymerize': [574, 921], 'rapidly': [577, 3769], 'pure': [579], 'filamentsin': [581], 'vitro.': [582], 'Proteins': [583], 'family': [587, 919], 'promote': [591, 691], 'recycling': [592], '(for': [595], 'review,': [596], 'see': [597, 1772], 'Refs.': [598], '5Moon': [599], 'Drubin': [601], 'D.G.': [602], 'Mol.': [603], 'Cell.': [605, 619, 1707], '1995;': [606], '6:': [607], '1423-1431Crossref': [608], '(227)': [611], 'Scholar': [613], '6Carlier': [615], 'M.F.': [616, 641, 694, 1099, 1903, 2519, 2665, 2784, 3863], 'Curr.': [617], 'Opin.': [618], '10:': [622, 799], '45-51Crossref': [623], '(177)': [626], 'Scholar),': [628, 955, 996, 1054, 1072, 1693, 2594, 2619, 2658, 2912, 3890], 'they': [630], 'enhance': [631, 763], 'Listeriacomet': [638], 'tails': [639], '(7Carlier': [640, 693, 1098, 1902, 2664, 2783, 3862], 'Laurent': [642, 695, 1100, 1904, 2520, 2666, 2785, 3864], 'V.': [643, 696, 1101, 1905, 2521, 2667, 2786, 3865], 'Santolini': [644, 697, 1102, 1906, 2522, 2668, 2787, 3866], 'Melki': [646, 699, 1104, 1908, 2524, 2670, 2789, 3868], 'R.': [647, 700, 1105, 1909, 2063, 2525, 2671, 2790, 3869], 'Didry': [648, 701, 1106, 1129, 1910, 2526, 2567, 2672, 2695, 2791, 3870, 4070], 'Xia': [650, 703, 1108, 1131, 1912, 2528, 2569, 2674, 2697, 2793, 3872, 4072], 'G.X.': [651, 704, 1109, 1913, 2529, 2675, 2794, 3873], 'Hong': [652, 705, 1110, 1133, 1914, 2530, 2571, 2676, 2699, 2795, 3874, 4074], 'Chua': [654, 707, 1112, 1135, 1916, 2532, 2573, 2678, 2701, 2797, 3876, 4076], 'N.H.': [655, 708, 1113, 1917, 2533, 2679, 2798, 3877], 'Pantaloni': [656, 709, 1114, 1137, 1161, 1918, 2534, 2575, 2680, 2703, 2799, 3878, 4078], '1997;': [661, 682, 714, 1119, 1923, 2539, 2612, 2685, 2804, 3883], '136:': [662, 683, 715, 1120, 1924, 2540, 2686, 2805, 3884], '1307-1322Crossref': [663, 716, 1121, 1925, 2541, 2687, 2806, 3885], '(837)': [666, 719, 1124, 1928, 2544, 2690, 2809, 3888], '8Rosenblatt': [669], 'Agnew': [671], 'B.J.': [672, 725, 981, 1039, 2549, 2643], 'Abe': [673], 'H.': [674, 828, 863, 2454], 'Bamburg': [675, 905, 2507], 'J.R.': [676, 906, 2508], '1323-1332Crossref': [684], '(190)': [687], 'depolymerization': [692, 764, 2660, 3081], '9Maciver': [722, 1036, 2640], 'S.K.': [723, 793, 840, 887, 940, 979, 1020, 1037, 1572, 1576, 2468, 2489, 2547, 2624, 2641, 4435], 'Pope': [724, 884, 980, 1038, 2486, 2548, 2603, 2642], 'Whytock': [726, 982, 1040, 2550, 2644], 'Weeds': [728, 888, 984, 1042, 2490, 2552, 2607, 2646], 'A.G.': [729, 889, 985, 1043, 2491, 2553, 2647], 'Eur.': [730, 986, 1044, 1757, 2554, 2648, 2761], 'Biochem.': [732, 830, 988, 1046, 1759, 2409, 2556, 2650, 2763], '256:': [734, 990, 1048, 2558, 2652], '388-397Crossref': [735, 991, 1049, 2559, 2653], '(117)': [738, 994, 1052, 2562, 2656], '10Du': [741], 'Frieden': [743, 1062, 1080, 2406], 'C.': [744, 1063, 1081, 1574, 1863, 2407], 'Biochemistry.': [745, 890, 907, 1064, 1082, 1585, 2068, 2492, 2509], '37:': [747, 1066, 1084], '13276-13284Crossref': [748, 1067, 1085], '(82)': [751, 1070, 1088], 'major': [755, 3532], 'point': [756, 3736], 'disagreement': [758], 'whether': [760, 4473], 'severing': [766, 784, 2620, 3079, 4487], 'increasing': [770], 'subunit': [774, 787, 1200], 'dissociation': [775, 788, 1203, 1423, 2297, 2393, 3219, 3261, 3418, 3996, 4106], 'one': [777], 'both': [779, 783], 'ends,': [780], 'rapid': [786, 3159, 3832], '(reviewed': [789], 'Ref.': [791, 1773], '11Maciver': [792], 'Curr': [794], 'Opin': [795], '140-144Crossref': [800], '(95)': [803], 'Early': [806], 'papers': [807], '(12Mabuchi': [808], 'I.': [809, 869, 3186], '1983;': [813, 2410], '97:': [814], '1612-1621Crossref': [815], '(102)': [818], '13Nishida': [821], 'E.': [822, 826, 859, 2452], 'Maekawa': [823], 'Muneyuki': [825], 'Sakai': [827, 862, 2453], '1984;': [831, 1686, 1779], '387-398Crossref': [833], '(38)': [836], '14Maciver': [839, 1019, 2467], 'Zot': [841, 941, 1021, 2469, 2625, 4436], 'H.G.': [842, 942, 1022, 2470, 2626, 4437], '115:': [849, 949, 1029, 2477, 2633, 4444], '1611-1620Crossref': [850, 950, 1030, 2478, 2634, 4445], '(197)': [853, 953, 1033, 2481, 2637, 4448], '15Moriyama': [856], 'K.': [857, 867, 1756, 2760], 'Nishida': [858, 2451], 'Yonezawa': [860], 'N.': [861, 2450], 'Matsumoto': [864], 'Iida': [866], 'Yahara': [868], '1990;': [873], '265:': [874], '5768-5773Abstract': [875], 'Full': [876, 973, 1013, 1147, 1149, 1169, 1171, 1320, 1322, 1540, 1542, 1643, 1645, 1672, 1711, 1872, 1966, 1968, 2461, 2585, 2587, 2713, 2715, 2903, 2905, 3398, 3400, 4088, 4090], 'Text': [877, 974, 1014, 1148, 1150, 1170, 1172, 1321, 1323, 1541, 1543, 1644, 1646, 1673, 1712, 1873, 1967, 1969, 2462, 2586, 2588, 2714, 2716, 2904, 2906, 3399, 3401, 4089, 4091], 'PDF': [878, 975, 1015, 1151, 1173, 1324, 1544, 1647, 1674, 1713, 1874, 1970, 2463, 2589, 2717, 2907, 3402, 4092], '16Hawkins': [882, 2484], 'M.': [883, 2485, 2928], 'B.': [885, 2487, 2604], 'Maciver': [886, 1571, 2488, 4431], '1993;': [891, 908, 1586, 2493, 2510], '32:': [892, 909, 1587, 2494, 2511], '9985-9993Crossref': [893, 2495], '(241)': [896, 2498], '17Hayden': [899, 2501], 'S.M.': [900, 2502], 'Miller': [901, 2503], 'P.S.': [902, 2504], 'Brauweiler': [903, 2505], '9994-10004Crossref': [910, 2512], '(204)': [913, 2515], 'proposed': [916], 'creating': [925], 'ends': [927, 1206, 1448, 2242], 'dissociate': [929], 'subunits.': [930], 'Several': [931], 'lines': [932, 3726], 'evidence': [934], 'support': [935], 'severing:': [936], 'direct': [937], 'visualization': [938], '(14Maciver': [939, 2623, 4434], 'electron': [956], 'microscopy': [957], '(18Cooper': [958, 998], 'Blum': [960, 1000], 'J.D.': [961, 1001], 'Williams': [962, 1002], 'Jr.,': [963, 1003], 'R.C.': [964, 1004], '1986;': [970, 1010], '261:': [971, 1011], '477-485Abstract': [972, 1012], 'Scholar,9Maciver': [978, 2546], 'viscometry': [997], 'kinetic': [1055], 'analysis': [1056, 3423], 'spontaneous': [1058, 2033, 2252], '(10Du': [1060, 1078], 'recovery': [1075, 3785], 'after': [1076, 1438, 2136, 3335, 4402], 'photobleaching': [1077], 'On': [1091], 'hand,': [1094], 'Carlier': [1095, 1139, 1159, 1864, 2066, 2577, 2705, 3859, 4080], 'colleagues': [1097], '19Ressad': [1127, 2565, 2693], 'F.': [1128, 2566, 2694, 4069], 'G.-X.': [1132, 2570, 2698, 4073], 'N.-H.': [1136, 2574, 2702, 4077], 'M.-F.': [1140, 1160, 1865, 2067, 2578, 2706, 4081], '273:': [1145, 1167, 1318, 1538, 1641, 1964, 2583, 2711, 2901, 3396, 4086], '20894-20902Abstract': [1146, 2584, 2712, 4087], '(153)': [1154, 2592, 2720, 4095], '20Didry': [1157], '25602-25611Abstract': [1168], '(164)': [1176], 'argue': [1179], 'effects': [1182, 1352], 'plant': [1184], 'human': [1186], 'ADF': [1187], 'might': [1192], 'be': [1193, 2843, 3898, 4102], 'explained': [1194], 'entirely': [1195], 'increased': [1197, 4033, 4171], 'rates': [1198], 'association': [1201, 2288], 'at': [1204, 1719, 1856, 1894, 1899, 1948, 1953, 2157, 2168, 2213, 3132, 3606, 3737, 3845, 4062, 4357], 'To': [1209, 2723, 3989], 'help': [1210], 'resolve': [1211], 'this': [1212, 2314, 2980, 3422, 3469, 3893, 4100, 4474], 'controversy,': [1213], 'we': [1214, 1261, 1370, 2727, 3891, 4001], 'done': [1216], 'new': [1217], 'experiments': [1218, 2002, 4385], 'withAcanthamoeba': [1219], 'family.': [1226], 'Because': [1227], 'number': [1237, 1257, 1445, 2264], 'overlapping': [1239, 2444], 'reactions': [1240, 1301, 2424, 2841, 3548], 'our': [1247], 'strategy': [1248], 'has': [1249, 1383], 'been': [1250], 'divide': [1252], 'problem': [1254], 'into': [1255], 'steps': [1259], 'can': [1262, 2817, 2842], 'examine': [1263], 'isolation': [1265], 'before': [1266], 'trying': [1267], 'formulate': [1269], 'an': [1270, 1294, 1800, 2109, 2864, 2873, 2890, 2921, 2941, 2961, 3097, 3413, 3570, 3757, 3804, 3836, 4024, 4146, 4216, 4315], 'overall': [1271], 'mechanism.': [1272], 'Ours': [1273], 'also': [1275, 3546], 'first': [1277, 1308, 2078, 2958, 3062], 'systematic': [1278], 'comparison': [1279], 'any': [1284], 'protein': [1286], 'cytoplasmic': [1288], 'important': [1295], 'point,': [1296], 'some': [1298, 2778, 4482], 'differ': [1302], 'two': [1305, 2196, 2729, 3794], 'actins.': [1306], 'Our': [1307, 3053], 'paper': [1309], '(21Blanchoin': [1310, 1530, 1633, 1956, 2893, 3388], 'L.': [1311, 1531, 1634, 1957, 2894, 3389], '25106-25111Abstract': [1319, 1539, 1642, 1965, 2902, 3397], '(144)': [1327, 1547, 1650, 1973, 2910, 3405], 'included': [1330], 'equilibrium': [1331, 1375, 2394, 3419, 4130], 'constants': [1334, 3950, 4123, 4131, 4296], 'ATP-': [1338], 'monomers,': [1341], 'actophorin-actin': [1346], 'complexes,': [1347], 'antagonistic': [1351], 'profilin': [1356], '(another': [1357], 'small': [1358, 3983], 'protein)': [1359], 'exchange': [1362], 'nucleotide': [1364], 'monomers.': [1368, 2309], 'Here,': [1369], 'characterize': [1371], 'kinetics': [1373, 2001, 4134], 'Binding': [1396, 2342], 'not': [1402, 4202, 4248, 4325, 4409, 4471], 'inhibits': [1415, 4455], 'binding,': [1417, 2829, 3551], 'so': [1418, 2859, 3477], 'hydrolysis': [1420], 'serve': [1424], 'as': [1425, 1768, 2177, 3009, 3105, 3577, 4279, 4297, 4486], 'timer': [1427], 'Reciprocally,': [1430], 'hydrolysis.': [1440], 'An': [1441, 4333], 'assay': [1442, 2025, 2191, 3085, 3558], 'filament': [1447, 2447, 2600, 2622, 2663, 2866, 2923], 'shows': [1449, 3156, 3675], 'concentration-': [1457], 'time-dependent': [1459], 'manner.': [1460], '10-fold': [1462, 3447], 'free': [1476, 2361, 2884], 'energy': [1477], 'change': [1478, 1889, 1942, 2185, 2597, 2818, 2951, 3140, 3199, 3272, 3613, 3645, 3696, 3796], 'drive': [1480], 'depolymerization.': [1481, 2835, 4489], 'Materials': [1482], 'came': [1483], 'following': [1486, 3143, 3275, 3616, 3648], 'sources:': [1487], 'Sigma,': [1488], 'dithiothreitol': [1489, 1496], '(DTT),': [1490], '1The': [1491], 'abbreviations': [1492], 'used': [1493, 1808, 2017, 2122, 2176, 2400, 2728], 'are:': [1494], 'DTT,': [1495, 1619, 3127, 3601], 'EDTA,': [1497, 1616], 'Tris,': [1498], 'sodium': [1499], 'azide,': [1500], 'Me2SO,': [1501], 'hexokinase,': [1502], 'ATP,': [1503, 1732, 3121, 3595], 'ADP,': [1504], 'phalloidin,': [1505], 'Sephadex': [1506], 'G-25': [1507], 'medium;': [1508], 'Molecular': [1509], 'Probes': [1510], '(Eugene,': [1511], 'OR),': [1512], 'tris-(2-carboxyethyl)phosphine,': [1513], 'tetramethylrhodamine': [1514, 1627], 'maleimide': [1515, 1628], '5′': [1516, 1629], 'isomer;': [1517], 'Whatman': [1518], '(Maidstone,': [1519], 'United': [1520, 2014], 'Kingdom),': [1521], 'DEAE-cellulose': [1522], 'DE-52.': [1523], 'Wild': [1524], 'type': [1525, 3147, 3280], 'S88C': [1527, 1623, 2743], 'mutant': [1528], 'actophorins': [1529, 1605], 'plasmid': [1551], 'vector': [1552], 'pMW172': [1553], 'were': [1554, 1606, 1836, 1977, 1990, 2098, 2130, 2235, 2331, 2344, 3104, 3576], 'expressed': [1555], 'inEscherichia': [1556], 'coli': [1557], 'strain': [1558], 'BL21': [1559], '(DE3)': [1560], 'pLysS': [1561], 'purified': [1563, 1632, 1655], 'according': [1564, 2278], 'Quirk': [1566], 'et': [1567, 3860, 4432], 'al.': [1568, 3861, 4433], '(22Quirk': [1569], 'Ampe': [1573], 'Doberstein': [1575], 'Kaiser': [1577], 'VanDamme': [1579], 'Vandekerckhove': [1581], 'J.S.': [1582], '8525-8533Crossref': [1588], '(54)': [1591], '2': [1595, 1617, 1847, 2204, 2349, 3114, 3181, 3235, 3312, 3491, 3512, 3526, 3587, 3619, 3651, 3743, 3842, 4008, 4186, 4197, 4213, 4304], 'mmdithiothreitol': [1596], 'buffers': [1599], 'avoid': [1601], 'cysteine': [1602], 'oxidation.': [1603], 'Purified': [1604], 'stored': [1607], 'mm': [1610, 1615, 1618, 1726, 1731, 1734, 1737, 1797, 1822, 1827, 1830, 1848, 1851, 2106, 3112, 3117, 3120, 3123, 3126, 3130, 3294, 3302, 3580, 3585, 3588, 3591, 3594, 3597, 3600, 3604, 3718], 'Tris-Cl,': [1611, 1727, 1831], 'pH': [1612, 1728, 1832, 3109, 3582], '7.5,': [1613], '1': [1614, 1620, 2282, 3116, 3349, 3590], 'mmNaN3.': [1621], 'was': [1624, 1654, 1697, 1740, 1789, 1812, 1885, 1938, 2175, 2192, 2200, 2220, 2270, 2319, 3245, 4221, 4277, 4340, 4354, 4408, 4475], 'labeled': [1625, 1741], 'isomer': [1630], 'acetone': [1660], 'powder': [1661], '(23Spudich': [1662], 'Watt': [1664], '1971;': [1669], '246:': [1670], '4866-4871Abstract': [1671], 'Acanthamoeba': [1680, 2438, 3208, 3451, 3915], '(24Pollard': [1681], '99:': [1687, 1780], '769-777Crossref': [1688, 1781], '(193)': [1691, 1784], 'monomeric': [1695, 3779, 3820, 4244], 'Ca-ATP-actin': [1696, 2083, 2088, 2119], 'isolated': [1698], 'Sephacryl': [1700], 'S-300': [1701], 'chromatography': [1702], '(25MacLean-Fletcher': [1703], '1980;': [1708], '20:': [1709], '329-341Abstract': [1710], '(549)': [1716], '4': [1720, 1860], '°C': [1721], 'G': [1723], 'buffer': [1724, 3524, 4206], '(5': [1725], '8.0,': [1729, 3110, 3583], '0.2': [1730, 1796, 2105, 3119, 3122, 3293, 3301, 3593, 3596], 'CaCl2,': [1735, 3124, 3598], 'DTT).': [1738], 'Cys-374': [1743], 'stoichiometry': [1746], '0.8–1.0': [1748], 'pyrene': [1750, 4031], 'iodoacetamide': [1751], '(Ref.': [1752], '26Kouyama': [1753], 'Mihashi': [1755, 2759], '1981;': [1760, 2764], '114:': [1761, 2765], '33-38Crossref': [1762, 2766], '(720)': [1765, 2769], 'Scholar;': [1767], 'modified': [1769], 'Pollard;': [1771], '24Pollard': [1774], 'Mg-ATP': [1787, 2095], 'G-actin': [1788], 'prepared': [1790, 1837, 2079, 2099], 'ice': [1792, 2101], 'addition': [1794, 1815, 2103, 2137], 'EGTA': [1798, 2107], '11-fold': [1801, 2110], 'molar': [1802, 2111], 'excess': [1803, 2112, 2942, 3098, 3571, 3758, 3805, 3828, 4025, 4147, 4217, 4301, 4316, 4387], 'MgCl2over': [1805], 'within': [1809, 2123], 'hours.': [1810, 2124], 'polymerized': [1813, 2225, 2748, 3777], '1:9': [1817, 2139], '(v/v)': [1818, 2140], '10×': [1819, 2141], 'KME': [1820, 2142, 2228], '(500': [1821], 'KCl,': [1823, 1846, 3113, 3586], 'mmMgCl2,': [1825, 3115], 'EGTA,': [1828, 3118, 3592], '100': [1829], '8).': [1833], 'ADP-BeF3-actin': [1834], 'polymerizing': [1839], '20': [1840, 3254], 'μm': [1841, 1854, 2205, 2224, 2232, 3151, 3236, 3242, 3255, 3278, 3284, 3620, 3633, 3652, 3667, 3957], 'Mg-ATP-actin': [1842], 'm': [1845], 'MgCl2,': [1849, 3589], 'NaF,': [1852], '150': [1853], 'BeCl2': [1855], 'room': [1857], 'temperature': [1858], 'h': [1861], '(27Combeau': [1862], '1988;': [1869], '263:': [1870], '17429-17436Abstract': [1871], 'Interaction': [1878, 1931, 2430], 'pyrenyl-labeled': [1882, 2736], 'followed': [1886, 1939, 3781, 4341], 'excitation': [1893, 1947], '366': [1895], 'nm': [1896, 1901, 1950, 1955, 2159, 2170], 'emission': [1898, 1952], '387': [1900], 'rhodamine-S88C-actophorin': [1933], 'unlabeled': [1935, 2206, 2944, 3094, 3229, 3256, 3339, 3573, 4027, 4050, 4219, 4318], '550': [1949], '574': [1954], 'Data': [1976], 'collected': [1978], 'Alphascan': [1981], 'spectrofluorometer': [1982], '(Photon': [1983], 'Technology': [1984], 'International,': [1985], 'South': [1986], 'Brunswick,': [1987], 'NJ).': [1988], 'Reactions': [1989], 'initiated': [1991], 'mixing': [1993, 3144, 3276, 3336, 3617, 3649], 'manually,': [1998], 'hand-driven': [2005], 'stopped-flow': [2006], 'mixer': [2007], '(Model': [2008], 'SFA-12,': [2009], 'Hi-tech': [2010], 'Scientific': [2011], 'Ltd.,': [2012], 'Salisbury,': [2013], 'Kingdom).': [2015], '2amino-6-mercapto-7-methyl': [2019], 'purine': [2020], 'riboside': [2021], 'purine-nucleoside': [2023], 'phosphorylase': [2024], 'measure': [2027, 3990], 'during': [2032, 4034], 'alone': [2037], 'presence': [2040, 3291, 3299, 3494, 3517, 4161], 'phalloidin': [2044], '(28Webb': [2045], 'M.R.': [2046], '1992;': [2054], '89:': [2055], '4884-4887Crossref': [2056], '(492)': [2059], '29Melki': [2062], 'Fievez': [2064], '1996;': [2069], '35:': [2070], '12038-12045Crossref': [2071], '(124)': [2074], '1:1': [2081, 2117], 'treatment': [2086], 'AG': [2091], '1-X4': [2092], 'Resin': [2093], '(Bio-Rad).': [2094], 'MgCl2': [2114], 'assembly': [2126], 'monitored': [2131], '400': [2133], 'μl': [2134], 'samples': [2135, 4144], 'Microplate': [2145], 'Spectrophotometer': [2146], 'system,': [2147], 'SECTRAmax': [2148], '250': [2149], '(Molecular': [2150], 'Devices': [2151], 'Corporation,': [2152], 'Sunnyvale,': [2153], 'CA)': [2154], 'using': [2155, 3179, 3310, 3685], 'absorbance': [2156, 2167, 2184], '310': [2158], '360': [2161, 2169], 'nm,': [2162], 'respectively.': [2163], 'increase': [2165, 2963, 2995, 3331], 'induced': [2171], 'blank': [2179], 'subtracted': [2181], 'due': [2186, 3065, 3899, 4476], 'release.': [2189], 'carried': [2193, 4002], 'out': [2194, 4003], 'steps.': [2197], 'First,': [2198], 'reacted': [2201], 'preformed': [2203], 'given': [2211], '25': [2214, 3133, 3607], '°C.': [2215, 3134], 'Then': [2216], 'reaction': [2218, 4285, 4313], 'mixture': [2219, 3233], 'diluted': [2221], '0.66': [2223], 'buffer,': [2229], 'added': [2236, 2261], 'growth': [2239], 'Under': [2246, 2310], 'these': [2247, 2725, 2840, 3948, 4129, 4418], 'conditions,': [2248], 'slower': [2256], 'elongation': [2258], 'concentration': [2265, 2306, 2324, 2377, 2384, 2985, 3049, 3202, 3345, 3359, 3699, 3852, 4048, 4274], '(N)': [2269], 'calculated': [2271, 4119], 'initial': [2274, 2317, 2994, 3158, 3833, 4334], 'Equation': [2280, 2347, 3369], '1,Rate=k+[A][N]−k−[N]Equation': [2281], 'where': [2283, 2350], 'k': [2284, 3190, 3691, 3926, 4395], 'constant': [2290, 2299, 2395, 2991, 3040, 3420, 3912, 3993, 4040, 4176], '(10': [2291], 's−1),k': [2293], '−': [2294], '(1': [2300], 's−1),': [2301], '[A]': [2303, 2380], 'conditions': [2312], 'assay,': [2315], 'directly': [2320], 'proportional': [2321], 'untreated': [2326], 'Kinetic': [2329], 'data': [2330, 2343, 3732, 3735], 'fit': [2332, 2345, 3178, 3309, 3684, 4263, 4326], 'exponentials': [2334], 'Kaleidagraph': [2336], 'software': [2337], '(Synergy': [2338], 'Software,': [2339], 'Reading,': [2340], 'PA).': [2341], '2,r=rcf+(rcb−rcf)[(Kd+[C]+[A])−(Kd+[C]+[A])2−(4[C][A])2]Equation': [2348], 'r': [2351], 'observed': [2354, 3910], 'anisotropy,r': [2355], 'cf': [2356], 'actophorin,r': [2362], 'cb': [2363], '[C]': [2373], 'total': [2376, 2383], 'K': [2389, 3953, 4117], 'complex.': [2398], 'KINSIM': [2401], '(30Barshop': [2402], 'Wrenn': [2404], 'R.F.': [2405], 'Anal.': [2408], '130:': [2411], '134-145Crossref': [2412], '(670)': [2415], 'simulate': [2419], 'including': [2437, 2446, 2781, 3484, 3537, 3552], 'complicated': [2441], 'several': [2443], 'reactions,': [2445, 2726], '(31Yonezawa': [2449], 'J': [2455], 'Biol': [2456], '260:': [2459], '14410-14412Abstract': [2460], '7Carlier': [2518], '(32McGough': [2601], 'Chiu': [2605], 'W.': [2606], '138:': [2613], '771-781Crossref': [2614], '(583)': [2617], 'study': [2724], 'assays:': [2731], 'intensity': [2734], 'rhodamine-labeled': [2742], 'actophorin.': [2744, 3574, 3701, 4361], 'Pyrenyl': [2745], '20-fold': [2752], '(26Kouyama': [2757], 'quenched': [2774], 'complication': [2813], 'three': [2825], 'different': [2826, 3538], 'mechanisms:': [2827], '(i)': [2828], '(ii)': [2830], 'conformational': [2831], 'change,': [2832], '(iii)': [2834], 'With': [2836, 3827, 4253], 'proper': [2837], 'experimental': [2838, 3171], 'design,': [2839], 'separated': [2844], 'time.': [2846], 'Fluorescence': [2847], 'sensitive': [2850], 'only': [2851], 'size': [2854], 'diffusing': [2857], 'species,': [2858], 'monomer.': [2875], 'rhodamine': [2879], '0.14': [2882, 2965], 'when': [2883, 2887, 4204], '0.21': [2886], 'monomer': [2892], 'whereas': [2913, 3073], 'polarization': [2915], 'rhodamine-phalloidin': [2918], 'immobilized': [2919], '0.30.': [2926], '2E.': [2927], 'De': [2929], 'La': [2930], 'Cruz': [2931], 'unpublished': [2936], 'observation.': [2937], 'Mixing': [2938], 'results': [2947, 3077, 3479], 'biphasic': [2950], '(Fig.1': [2955], 'A).': [2956], 'phase': [2959, 2981, 3029, 3063, 3076, 3195, 3795, 3834, 4405], 'exponential': [2962, 3033, 3837, 4329], '±': [2966, 2973, 3043, 3930, 3942, 3973, 4043, 4179, 4190], '0.005': [2967, 3943], 'maximum': [2970, 3330, 3355], '0.235': [2972], '0.005.': [2974], 'amplitude': [2978, 3327, 3356], 'range': [3002], 's−1,': [3006, 3045, 4045], 'accurately': [3012, 3986], '(due': [3013], 'less': [3015], 'noisy': [3016, 3296], 'data)': [3017], '(Fig.': [3025, 3348, 3490, 3525, 3786, 3822, 3841, 4007, 4164, 4185, 4196, 4212, 4227, 4234, 4257, 4303, 4330, 4390], '2).': [3026], 'second': [3028, 3075], 'slow': [3032, 3784], 'decrease': [3034, 3160, 3813, 3838, 3894, 4346], '0.012': [3042], '0.002': [3044], 'independent': [3046, 4046], 'interpretation,': [3054], 'elaborated': [3055, 4414], 'upon': [3056, 4415], 'under': [3057, 4416], '“Discussion,”': [3058, 4417], 'filaments.Figure': [3083], '2Fluorescence': [3084], 'pyrene-labeled': [3100, 3566], 'Conditions': [3103, 3575], 'follows:': [3106, 3578], 'mmTris-HCl,': [3108], '50': [3111, 3584], '3': [3129, 3603, 4228, 4235, 4258, 4331], 'NaN3': [3131, 3605], 'A,': [3135, 3843], '0.4': [3145, 3241], 'μmwild': [3146], 'Acanthamoebapyrenyl-actin': [3152], 'inset': [3155], 'faster': [3165, 4345], 'scale.': [3167], 'Noisy': [3168], 'curves': [3169, 3305, 3680], 'traces.': [3172], 'Smooth': [3173, 3304], 'curve': [3174, 3366], 'best': [3177, 3308, 3683], 'model': [3180, 3311, 3686], 'values': [3183, 3314, 4139], 'Table': [3185, 3316], 'B,': [3187, 3640, 4009], 'dependence': [3188, 3689, 4268, 4393], 'obs': [3191, 3692, 4271, 4396], 'fast': [3194], 'filaments:': [3205, 3287], 'closed': [3206, 3711, 3720], 'circles,': [3207, 3211, 3708, 3721], 'filaments;open': [3210], 'filaments.Inset,': [3214], 'competition': [3227], 'preincubated': [3246], 'min': [3249], 'then': [3251, 4018], 'mixed': [3252, 4222], 'filaments.C,': [3267], '0.6': [3277, 4125], 'wild': [3279], '6': [3283], 'dotted': [3288], 'line,': [3289, 3297], 'ADP;': [3295], 'ATP.': [3303, 4252], 'I.View': [3317], 'Large': [3318, 3745], 'Image': [3319, 3746], 'Figure': [3320, 3747], 'ViewerDownload': [3321, 3748], 'Hi-res': [3322, 3749], 'image': [3323, 3750], 'Download': [3324, 3751], '(PPT)': [3325, 3752], 'depends': [3342, 3424, 3849], 'B).': [3350, 3826, 3857, 4305, 4332], 'plot': [3352], 'versus': [3357], 'gives': [3363, 3951], 'saturation': [3365], 'fits': [3368, 3729], '2.': [3370], 'saturating': [3372], 'concentrations': [3373, 3625, 3657, 4359], '0.235,': [3380], 'lower': [3409], 'expected': [3411, 4280], 'filament.': [3415], 'apparent': [3417], 'source': [3427, 3486], '0.49': [3444], '5.6': [3457], 'μm).': [3458], 'Some': [3459], 'quench': [3462], 'However,': [3468], 'far': [3471], 'many': [3482], 'variables,': [3483], 'B),': [3492, 4236], 'γ-phosphate': [3497], '(see': [3503], 'Fig.': [3504, 3742], '4),': [3505], 'ratio': [3507, 3946], 'reactants': [3510], '(Figs.': [3511], '3),': [3514], 'ADP': [3521, 4208], 'C).': [3527, 4168, 4198, 4214, 4287, 4412], 'These': [3528], 'complications': [3529], 'arise': [3530], 'differences': [3533], 'actin,': [3536, 3780, 3966, 4115], 'affinities': [3539], 'degree': [3541], 'cooperativity,': [3544], 'follow': [3550], 'repolymerization.Figure': [3556], '3Fluorescence': [3557], 'Tris-HCl,': [3581], '°C.A,': [3608], 'pyrenyl-amoeba-actin': [3621], 'various': [3624, 3656], 'actophorin:': [3627, 3659], '15,': [3628], '20,': [3629], '30,': [3630], '40': [3632], 'top': [3636, 3670], 'bottom': [3638, 3672], 'curve,respectively.': [3639, 3673], 'pyrenyl-muscle-actin': [3653], '4,': [3660], '6,': [3661], '8,': [3662], '10,': [3663], '12,': [3664], '15': [3666], 'Inset': [3674], 'early': [3677], 'course.Smooth': [3679], '1.': [3687], 'C,': [3688], 'In': [3702, 4306, 4382], 'absence': [3704], 'phosphate:': [3706, 3719], 'open': [3707], 'actin;': [3710, 3714], 'squares,': [3712], '68': [3717], 'solid': [3725], 'manual': [3728], 'points.': [3733], 'zero': [3738], 'comes': [3740], 'B.View': [3744], 'Reaction': [3753, 3802], 'biphasic:': [3765], 'falls': [3768], 'value': [3772], 'intermediate': [3773], 'between': [3774], '2,': [3787, 4165], 'C),': [3790], 'similar': [3791], 'rhodamine-actophorin.': [3801], 'causes': [3810], 'monotonic': [3812], 'level': [3818, 4242], '3,': [3823], 'inset)': [3844], '(Fig.2': [3856], 'Like': [3858], 'interpret': [3892, 4099], 'Plots': [3907], 'versusconcentration': [3913], 'linear': [3919, 4410], 'slope': [3922, 3968, 4289], '(association': [3923], 'constant,': [3925], '+1)': [3927, 3970], '0.029': [3929], '0.003': [3931], 's−1and': [3933], 'y-intercept': [3935], '(dissociation': [3936], 'constant,k': [3938], '−1)': [3939], '0.11': [3941], 's−1.': [3944], '3.8': [3956], 'For': [3964, 4113], '0.008': [3972], '0.0005': [3974, 4044, 4191], 's−1': [3976, 4067, 4181, 4192], 'they-intercept': [3978], 'near': [3980], 'zero,': [3981], 'too': [3982], 'estimate': [3985], 'extrapolation.': [3988], 'chase': [4005, 4036, 4056], 'experiment': [4006, 4299], 'inset).': [4010], 'competed': [4019], 'it': [4020], 'off': [4021], 'adding': [4023], '0.0050': [4042], 'Unlabeled': [4053], 'ADF-1': [4057], 'NBD-labeled': [4059], '0.035': [4066], '(19Ressad': [4068], 'μm.': [4126], 'Both': [4127, 4362], 'derived': [4132], 'agree': [4135], 'well': [4136], 'anisotropy.': [4142], 'After': [4143], 'reached': [4151], 'minimum': [4153], 'fluorescence,': [4154], 'recovered': [4157], 'exponentially': [4172], '0.015': [4178], '0.001': [4180], 'A)': [4187, 4229], '0.0030': [4189], 'did': [4201, 4247, 4470], 'recover': [4203, 4249], 'contained': [4207], 'rather': [4209], 'When': [4215], 'decreased': [4239], 'A),': [4259], 'courses': [4262], 'single': [4264, 4328], 'exponentials,': [4265], 'thek': [4270], 'linear,': [4278], '(Fig.3': [4286, 4411], 'intercept': [4291], 'give': [4292], 'contrast,': [4307], 'does': [4324], 'lag': [4335, 4353, 4367, 4404], 'few': [4338], 'seconds': [4339], 'progressively': [4344], 'baseline': [4350], 'level.': [4351], 'most': [4355], 'pronounced': [4356], 'low': [4358, 4463], 'duration': [4364], 'subsequent': [4373, 4483], 'decline': [4374, 4399], 'concentration.': [4381], 'contrast': [4383], '2),': [4391], 'fluorescent': [4401], 'As': [4413], 'features': [4419], 'suggest': [4420], 'found': [4451], 'inorganic': [4453], 'ability': [4457], 'reduce': [4461], 'shear': [4464], 'viscosity': [4465], 'establish': [4472], 'inhibition': [4478], 'such': [4485], 'half': [4491], 'maximal': [4492], 'e': [4493]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2133950971', 'counts_by_year': [{'year': 2024, 'cited_by_count': 18}, {'year': 2023, 'cited_by_count': 16}, {'year': 2022, 'cited_by_count': 17}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 11}, {'year': 2019, 'cited_by_count': 17}, {'year': 2018, 'cited_by_count': 15}, {'year': 2017, 'cited_by_count': 4}, {'year': 2016, 'cited_by_count': 13}, {'year': 2015, 'cited_by_count': 15}, {'year': 2014, 'cited_by_count': 7}, {'year': 2013, 'cited_by_count': 16}, {'year': 2012, 'cited_by_count': 5}], 'updated_date': '2025-01-06T20:10:24.844173', 'created_date': '2016-06-24'}