Transcriptional co‐factor Transducin beta‐like (<scp>TBL</scp>) 1 acts as a checkpoint in pancreatic cancer malignancy

Name: Work Video:
Duration: 3 min 30 s
Christian Stoy; Aishwarya Sundaram; Marcos Ríos García; Xiaoyue Wang; Oksana Seibert; Annika Zota; Susann Wendler; David Männle; Ulf Hinz; Carsten Sticht; Maria Muciek; Norbert Gretz; Adam J. Rose; Vera Greiner; Thomas G. Hofmann; Andrea S. Bauer; Jörg D. Hoheisel; Mauricio Berriel Díaz; Matthias M. Gaida; Jens Werner; Tobias Schafmeier; Oliver Strobel; Stephan Herzig
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1370, 1451, 1454, 1473, 1506, 1517], '(DKFZ)': [32, 66, 102, 136, 170, 204, 371, 404, 429, 451, 473, 499, 590, 665, 716, 750, 786, 820, 854, 888, 1055, 1088, 1113, 1135, 1157, 1183, 1274, 1349, 1452, 1507, 1518], 'Heidelberg,': [33, 44, 67, 78, 103, 114, 137, 148, 171, 182, 205, 216, 252, 253, 272, 273, 292, 293, 372, 383, 405, 406, 430, 431, 452, 453, 474, 475, 500, 511, 548, 567, 568, 591, 602, 640, 641, 666, 677, 717, 728, 751, 762, 787, 798, 821, 832, 855, 866, 889, 900, 936, 937, 956, 957, 976, 977, 1056, 1067, 1089, 1090, 1114, 1115, 1136, 1137, 1158, 1159, 1184, 1195, 1232, 1251, 1252, 1275, 1286, 1324, 1325, 1350, 1361, 1453, 1464, 1489, 1490, 1508, 1509, 1519, 1520, 1527], 'for': [35, 47, 69, 81, 105, 117, 139, 151, 173, 185, 207, 219, 236, 256, 276, 296, 314, 332, 350, 374, 386, 409, 434, 456, 478, 502, 514, 531, 551, 571, 593, 605, 622, 644, 668, 680, 697, 719, 731, 753, 765, 789, 801, 823, 835, 857, 869, 891, 903, 920, 940, 960, 980, 998, 1016, 1034, 1058, 1070, 1093, 1118, 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1304, 1326, 1362, 1379, 1465, 1482, 1491, 1498, 1510, 1521, 1528], 'Search': [46, 80, 116, 150, 184, 235, 255, 275, 295, 313, 331, 349, 385, 408, 433, 455, 477, 530, 550, 570, 621, 643, 696, 730, 764, 800, 834, 868, 919, 939, 959, 979, 997, 1015, 1033, 1069, 1092, 1117, 1139, 1161, 1214, 1234, 1254, 1305, 1327, 1380], 'more': [48, 82, 118, 152, 186, 237, 257, 277, 297, 315, 333, 351, 387, 410, 435, 457, 479, 532, 552, 572, 623, 645, 698, 732, 766, 802, 836, 870, 921, 941, 961, 981, 999, 1017, 1035, 1071, 1094, 1119, 1141, 1163, 1216, 1236, 1256, 1307, 1329, 1382, 1885, 1934], 'papers': [49, 83, 119, 153, 187, 238, 258, 278, 298, 316, 334, 352, 388, 411, 436, 458, 480, 533, 553, 573, 624, 646, 699, 733, 767, 803, 837, 871, 922, 942, 962, 982, 1000, 1018, 1036, 1072, 1095, 1120, 1142, 1164, 1217, 1237, 1257, 1308, 1330, 1383], 'by': [50, 84, 120, 154, 188, 239, 259, 279, 299, 317, 335, 353, 389, 412, 437, 459, 481, 534, 554, 574, 625, 647, 700, 734, 768, 804, 838, 872, 923, 943, 963, 983, 1001, 1019, 1037, 1073, 1096, 1121, 1143, 1165, 1218, 1238, 1258, 1309, 1331, 1384, 1616, 2766, 2799, 3219, 3825, 3836, 3844, 3901, 3965], 'this': [51, 85, 121, 155, 189, 240, 260, 280, 300, 318, 336, 354, 390, 413, 438, 460, 482, 535, 555, 575, 626, 648, 701, 735, 769, 805, 839, 873, 924, 944, 964, 984, 1002, 1020, 1038, 1074, 1097, 1122, 1144, 1166, 1219, 1239, 1259, 1310, 1332, 1385, 1534, 2169, 2255], 'author': [52, 86, 122, 156, 190, 241, 261, 281, 301, 319, 337, 355, 391, 414, 439, 461, 483, 536, 556, 576, 627, 649, 702, 736, 770, 806, 840, 874, 925, 945, 965, 985, 1003, 1021, 1039, 1075, 1098, 1123, 1145, 1167, 1220, 1240, 1260, 1311, 1333, 1386, 1585], 'Aishwarya': [53, 55, 737, 739, 1391], 'Sundaram': [54, 56, 738, 740], 'Marcos': [87, 90, 771, 774, 1393], 'Rios': [88, 91, 772, 775, 1394], 'Garcia': [89, 92, 773, 776], 'Xiaoyue': [123, 125, 807, 809, 1396], 'Wang': [124, 126, 808, 810], 'Oksana': [157, 159, 841, 843, 1398], 'Seibert': [158, 160, 842, 844], 'Annika': [191, 193, 875, 877, 1400], 'Zota': [192, 194, 876, 878], 'Institute': [218, 513, 543, 604, 679, 902, 1197, 1227, 1288, 1363], 'Diabetes': [220, 231, 515, 526, 606, 617, 681, 692, 904, 915, 1199, 1210, 1290, 1301, 1365, 1376, 1468, 1479], 'IDC,': [223, 518, 609, 684, 907, 1202, 1293, 1368, 1471], 'Helmholtz': [224, 519, 610, 685, 908, 1203, 1294, 1369, 1472], 'Munich': [226, 521, 612, 687, 910, 1205, 1296, 1371, 1474], 'Heidelberg-IDC': [229, 524, 615, 690, 913, 1208, 1299, 1374, 1477], 'Translational': [230, 525, 616, 691, 914, 1209, 1300, 1375, 1478], 'Program,': [232, 527, 618, 693, 916, 1211, 1302, 1377, 1480], 'Neuherberg,': [233, 528, 619, 694, 917, 1212, 1303, 1378, 1481], 'Susann': [242, 244, 926, 928, 1402], 'Wendler': [243, 245, 927, 929], 'Department': [246, 266, 286, 561, 634, 930, 950, 970, 1245, 1318], 'of': [247, 267, 287, 544, 562, 635, 931, 951, 971, 1228, 1246, 1319, 1484, 1523, 1563, 1573, 1609, 1627, 1638, 1665, 1716, 1740, 1754, 1770, 1834, 1842, 1859, 1882, 1898, 1908, 1937, 1960, 2018, 2033, 2046, 2065, 2087, 2096, 2132, 2160, 2176, 2195, 2227, 2240, 2254, 2273, 2302, 2308, 2368, 2390, 2399, 2459, 2476, 2488, 2516, 2673, 2697, 2720, 2776, 2860, 2882, 2894, 2907, 2961, 2984, 3004, 3023, 3031, 3083, 3116, 3137, 3143, 3156, 3163, 3177, 3186, 3234, 3277, 3306, 3393, 3399, 3424, 3524, 3559, 3823, 3847, 3917, 3931, 3994, 4024, 4080, 4176], 'General': [248, 268, 288, 563, 636, 932, 952, 972, 1247, 1320, 1485], 'Surgery,': [249, 269, 289, 564, 637, 933, 953, 973, 1248, 1321, 1486], 'Hospital': [251, 271, 291, 566, 639, 935, 955, 975, 1250, 1323, 1488], 'David': [262, 264, 946, 948, 1404], 'Männle': [263, 265, 947, 949], 'Ulf': [282, 284, 966, 968, 1406], 'Hinz': [283, 285, 967, 969], 'Carsten': [302, 304, 986, 988, 1408], 'Sticht': [303, 305, 987, 989], 'Medical': [306, 324, 342, 990, 1008, 1026], 'Center,': [308, 326, 344, 992, 1010, 1028, 1494], 'Klinikum': [309, 327, 345, 993, 1011, 1029, 1495], 'Mannheim,': [310, 311, 328, 329, 346, 347, 994, 995, 1012, 1013, 1030, 1031, 1496, 1497], 'Maria': [320, 322, 1004, 1006, 1410], 'Muciek': [321, 323, 1005, 1007], 'Norbert': [338, 340, 1022, 1024, 1412], 'Gretz': [339, 341, 1023, 1025], 'Adam': [356, 359, 1040, 1043, 1414], 'J': [357, 360, 1041, 1044, 1415], 'Rose': [358, 361, 1042, 1045], 'Vera': [392, 394, 1076, 1078, 1417], 'Greiner': [393, 395, 1077, 1079], 'Group': [397, 422, 1081, 1106, 1500], 'Cellular': [398, 423, 1082, 1107, 1501], 'Senescence,': [399, 424, 1083, 1108, 1502], 'Thomas': [415, 418, 1099, 1102, 1419], 'G.': [416, 419, 1100, 1103, 1420], 'Hofmann': [417, 420, 1101, 1104], 'Andrea': [440, 442, 1124, 1126, 1422], 'Bauer': [441, 443, 1125, 1127], 'Functional': [444, 466, 1128, 1150], 'Genome': [445, 467, 1129, 1151, 1512], 'Analysis,': [446, 468, 1130, 1152, 1513], 'Jörg': [462, 464, 1146, 1148, 1424], 'Hoheisel': [463, 465, 1147, 1149], 'Mauricio': [484, 487, 1168, 1171, 1426], 'Berriel': [485, 488, 1169, 1172, 1427], 'Diaz': [486, 489, 1170, 1173, 2204], 'Matthias': [537, 540, 1221, 1224, 1429], 'M': [538, 541, 1222, 1225, 1430], 'Gaida': [539, 542, 1223, 1226], 'Pathology,': [545, 1229, 1524], 'Jens': [557, 559, 1241, 1243, 1432], 'Werner': [558, 560, 1242, 1244], 'Tobias': [577, 579, 1261, 1263, 1434], 'Schafmeier': [578, 580, 1262, 1264], 'Oliver': [628, 632, 1312, 1316, 1436], 'Strobel': [629, 633, 1313, 1317, 1437], 'Corresponding': [630, 652, 1314, 1336], 'Author': [631, 653, 1315, 1337, 1387], 'Stephan': [650, 654, 1334, 1338, 1440], 'Herzig': [651, 655, 1335, 1339, 1441], 'Information': [1388], 'Stoy1,': [1390], 'Sundaram1,': [1392], 'Garcia1,‡,': [1395], 'Wang1,‡,': [1397], 'Seibert1,': [1399], 'Zota1,2,': [1401], 'Wendler3,': [1403], 'Männle3,': [1405], 'Hinz3,': [1407], 'Sticht4,': [1409], 'Muciek4,': [1411], 'Gretz4,': [1413], 'Rose1,': [1416], 'Greiner5,': [1418], 'Hofmann5,': [1421], 'Bauer6,': [1423], 'Hoheisel6,': [1425], 'Diaz1,2,': [1428], 'Gaida7,': [1431], 'Werner3,': [1433], 'Schafmeier1,2,': [1435], '3,‡': [1438], '1,2,‡': [1442], '1Joint': [1443], '2Institute': [1466], '3Department': [1483], '4Medical': [1492], '5Research': [1499], '6Functional': [1511], '7Institute': [1522], '‡These': [1529], 'authors': [1530], 'contributed': [1531], 'equally': [1532], 'to': [1533, 1587, 1590, 1622, 1728, 1788, 1853, 1943, 1972, 1986, 2006, 2090, 2189, 2247, 2331, 2521, 2551, 2724, 2728, 2978, 2997, 3080, 3101, 3109, 3172, 3202, 3806, 3815, 3925, 4058], 'work': [1535], '*Corresponding': [1536], 'author.': [1537, 1545], 'Tel:': [1538, 1546], '+49': [1539, 1547, 1551], '6221': [1540, 1548, 1552], '566110;': [1541], 'E-mail:': [1542, 1554], '[email': [1543, 1555], 'protected]': [1544, 1556], '423594;': [1549], 'Fax:': [1550], '423595;': [1553], 'EMBO': [1557], 'Mol': [1558], 'Med': [1559], '(2015)7:1048-1062https://doi.org/10.15252/emmm.201404837': [1560], 'PDFDownload': [1561], 'PDF': [1562], 'article': [1564], 'text': [1565], 'main': [1567, 2044], 'figures.': [1568], 'Peer': [1569], 'ReviewDownload': [1570], 'summary': [1572], 'the': [1574, 1605, 1636, 1751, 1768, 1860, 1904, 1957, 1990, 2034, 2043, 2085, 2094, 2105, 2117, 2130, 2158, 2172, 2214, 2224, 2237, 2248, 2251, 2274, 2299, 2332, 2342, 2357, 2360, 2396, 2402, 2445, 2543, 2683, 2740, 2980, 3077, 3093, 3135, 3144, 3174, 3256, 3303, 3832, 3918, 3928, 4022, 4066], 'editorial': [1575, 1579], 'decision': [1576, 1580], 'process': [1577, 4163], 'including': [1578, 2069], 'letters,': [1581], 'reviewer': [1582], 'comments': [1583], 'responses': [1586], 'feedback.': [1588], 'ToolsAdd': [1589], 'favoritesDownload': [1591], 'CitationsTrack': [1592], 'CitationsPermissions': [1593], 'ShareFacebookTwitterLinked': [1594], 'InMendeleyWechatReddit': [1595], 'Figures': [1596], '&': [1597, 1976, 2082, 2165, 2338, 2351, 3800], 'Info': [1598], 'Abstract': [1599], 'Pancreatic': [1600], 'ductal': [1601, 1821, 1865, 2748, 2867, 2944, 3191], 'adenocarcinoma': [1602, 1866, 2556, 2868, 2945, 3192], '(PDAC)': [1603], 'is': [1604, 1786, 1816, 1837, 1868, 1902, 1925, 1956, 2378, 2461, 2711, 2790, 3053, 3911], 'fourth': [1606, 1905], 'leading': [1607, 1906], 'cause': [1608, 1907], 'fatalities': [1611, 1910], 'Western': [1613, 1912], 'societies,': [1614], 'characterized': [1615], 'high': [1617, 1873, 2449, 2514], 'metastatic': [1618], 'potential': [1619, 2388, 2981, 3810], 'resistance': [1621, 2123], 'chemotherapy.': [1623], 'Critical': [1624], 'molecular': [1625, 1765, 2107, 3929], 'mechanisms': [1626, 2108, 3930], 'these': [1628, 2196, 2975, 3032, 3044, 3969, 4013], 'phenotypical': [1629], 'features': [1630], 'still': [1631, 2125], 'remain': [1632], 'unknown,': [1633], 'thus': [1634, 2355], 'hampering': [1635, 2129], 'development': [1637, 2131, 2234], 'effective': [1639, 2133], 'prognostic': [1640], 'therapeutic': [1642, 1877, 2134], 'measures': [1643], 'PDAC.': [1645, 1663, 1772, 3011, 3148], 'Here,': [1646], 'we': [1647, 2221, 2296, 2354, 2394, 2470, 2988, 3062, 3938], 'show': [1648], 'that': [1649, 2223, 2265, 2359, 2456, 2495, 2513, 3134, 3258, 3297, 3858, 3950, 4065], 'transcriptional': [1650, 1709, 1775, 1813, 1840, 2139, 2148, 2178, 2229, 2263, 2362, 3915], 'was': [1656, 1745, 3036, 3107, 4054], 'over-expressed': [1657, 2380], 'both': [1659, 1701, 2526, 3267, 3280], 'human': [1660, 1668, 1741, 1771, 2027, 2382, 2403, 2714, 2811, 3058, 3094, 3189, 3268, 3281, 3997], 'murine': [1662, 2025, 3237, 3270, 3283], 'Inactivation': [1664, 3822], 'TBL1': [1666, 1696, 1699, 1722, 1744, 1796, 1815, 1823, 1844, 2326, 2361, 2377, 2391, 2400, 2424, 2450, 2460, 2492, 2507, 2517, 2710, 2778, 2788, 2809, 2889, 2985, 2990, 3034, 3051, 3106, 3138, 3149, 3164, 3178, 3187, 3235, 3259, 3278, 3298, 3312, 3816, 3824, 3859, 3880, 3910, 3932, 3966, 3995, 4035, 4059, 4092], 'mouse': [1670, 2716, 3060, 3124, 3999], 'cells': [1673, 1718, 1962, 2243, 2524, 2869, 2946, 3159, 3194, 3216, 3240, 3286, 3328, 3395, 3456, 3471, 3530, 3562, 3794, 3830, 3884, 3970, 4000, 4025, 4041], 'reduced': [1674, 3245, 3831, 3875, 3991], 'cellular': [1675, 2162, 2216, 3151, 3833, 3876], 'proliferation': [1676, 1828, 3208, 3247, 3955, 4083], 'invasiveness,': [1678], 'correlating': [1679], 'with': [1680, 1730, 1778, 1872, 2144, 2463, 2785, 2793, 2819, 2834, 2844, 2853, 2870, 2904, 2924, 2931, 2938, 2947, 2995, 3039, 3120, 3213, 3386, 3396, 3520, 3563, 3775, 3873, 4012, 4039], 'diminished': [1681, 3885], 'glucose': [1682, 3834, 3877, 3887], 'uptake,': [1683], 'glycolytic': [1684, 3886], 'flux,': [1685], 'oncogenic': [1687, 1791, 2019, 2333], 'PI3': [1688, 1710, 1731, 1805, 1835, 3919], 'kinase': [1689, 1711, 1732, 1806, 1836, 2080], 'signaling': [1690, 2067, 2335, 3921], 'which': [1691, 1967, 2037, 2088, 3803, 3979], 'turn': [1693, 2061], 'could': [1694, 2471, 2534], 'rescue': [1695], 'deficiency-dependent': [1697], 'phenotypes.': [1698], 'deficiency': [1700, 3817, 3967], 'prevented': [1702], 'reversed': [1704], 'tumor': [1706, 1826, 1848, 2048, 2242, 2756, 3289, 3308, 3869, 3936], 'growth,': [1707], 'mediated': [1708], 'inhibition,': [1712], 'increased': [1714, 2547, 2856], 'chemosensitivity': [1715], 'PDAC': [1717, 1742, 1924, 1954, 2047, 2110, 2233, 2346, 2383, 2412, 2679, 2717, 2993, 3168], 'vivo.': [1720, 1811, 1856], 'As': [1721], 'mRNA': [1723, 2425, 2451, 2718], 'levels': [1724, 1733, 2398, 2426, 2452, 2515], 'were': [1725, 2420, 2427, 2519, 3959, 3990], 'also': [1726, 2328, 3244, 3807, 4076], 'found': [1727, 2188, 3108], 'correlate': [1729], 'overall': [1735, 2998, 3041, 3132, 3295], 'survival': [1736, 1896, 2781, 2999, 3042], 'cohort': [1739, 3003], 'patients,': [1743, 2698, 3033], 'identified': [1746, 2023, 2153], 'malignant': [1752, 2183, 3074], 'behavior': [1753], 'its': [1758], 'expression': [1759, 2175, 2226, 2301, 2397, 2458, 2719, 2779, 2789, 2991, 3035, 3082, 3165, 3398], 'may': [1760, 2245, 2364, 3860, 4075], 'serve': [1761], 'novel': [1764], 'target': [1766, 1841], 'treatment': [1769, 1945], 'Synopsis': [1773], 'The': [1774, 1812, 1831, 3160], 'TBL1,': [1777], 'known': [1779], 'functions': [1780], 'liver': [1782], 'adipose': [1784], 'tissue,': [1785, 2432], 'shown': [1787, 2686], 'be': [1789, 2091, 2536, 3110], 'an': [1790, 2366, 2474, 2500, 3001], 'driver': [1792, 2045], 'cancer.': [1795, 2375], 'inactivation': [1797], 'curbs': [1798], 'growth': [1800, 3263, 3317, 3423], 'aggressiveness': [1802], 'regulates': [1804], 'vitro': [1808], 'highly': [1817, 2379, 3111], 'overexpressed': [1818, 2712], 'adenocarcinoma.': [1822], 'controls': [1824, 3150, 3313], 'cell': [1827, 2540, 3026, 3182, 3207, 3210, 3223, 3246, 3290, 3316, 3335, 3404, 3433, 3537, 3580, 3954, 3957, 4085, 4134, 4178], 'invasion.': [1830], 'p110α': [1832], 'subunit': [1833], 'direct': [1839, 3913], 'TBL1.': [1843], 'inhibition': [1845, 4060], 'reduces': [1846], 'size': [1849], 'enhances': [1851], 'sensitivity': [1852], 'gemcitabine': [1854], 'Introduction': [1857], 'Malignancy': [1858], 'exocrine': [1861], 'pancreas,': [1862, 2544], 'particular': [1864, 3121], '(PDAC),': [1867], 'detrimental': [1870, 2121], 'disease': [1871], 'lethality': [1874], 'limited': [1876], 'options.': [1878], 'This': [1879], 'severe': [1880], 'form': [1881], 'causes': [1884], 'than': [1886, 1935], '200,000': [1887], 'deaths': [1888], 'worldwide': [1889], 'every': [1890], 'year': [1891], 'has': [1893, 1980, 2021, 2038, 2185, 2266, 2327], '5-year': [1895], 'rate': [1897], 'only': [1899, 1940, 2826], '4%.': [1900], 'It': [1901], 'therewith': [1903], 'societies': [1913], '(Raimondi': [1914], 'et': [1915, 1919, 1947, 1994, 2013, 2055, 2101, 2205, 2209, 2291, 2317, 2321, 3097], 'al,': [1916, 1920, 1948, 1995, 2014, 2056, 2102, 2206, 2210, 2292, 2318, 2322, 3098], '2009;': [1917], 'Vincent': [1918, 2054], '2011).': [1921, 1949, 1978, 2015, 2057], 'At': [1922], 'diagnosis,': [1923], 'already': [1926], 'metastasized': [1927], 'or': [1928, 2825, 2896, 3231, 3427], 'locally': [1929], 'advanced': [1930], 'non-resectable': [1932], '80%': [1936], 'cases': [1938], 'poorly': [1941, 2126], 'responds': [1942], 'chemotherapeutic': [1944], '(Vincent': [1946, 2012], 'An': [1950], 'early': [1951], 'event': [1952, 2307], 'tumorigenesis': [1955, 2099, 2464], 'metaplastic': [1958], 'reorganization': [1959], 'acinar': [1961, 3025], 'into': [1963, 2001, 3828], 'duct-like': [1964], 'structures': [1965], '(ADM),': [1966], 'commonly': [1968], 'occurs': [1969], 'response': [1971, 3814, 4057], 'inflammatory': [1973, 2501], 'challenges': [1974], '(Reichert': [1975], 'Rustgi,': [1977], 'Metaplasia': [1979], 'been': [1981, 2022, 2039, 2152, 2187, 2267, 2329], 'at': [1982, 2434], 'least': [1983], 'partially': [1984], 'attributed': [1985], 'acinar-to-ductal': [1987], 'transdifferentiation': [1988], 'adult': [1991], 'pancreas': [1992, 2404, 3078], '(Strobel': [1993], '2007).': [1996], 'Initial': [1997], 'metaplasia': [1998], 'might': [1999], 'progress': [2000], 'precursor': [2003], 'lesions': [2004, 2553, 2833, 2923, 2930, 3071, 3126], 'referred': [2005], 'intraepithelial': [2009], 'neoplasia': [2010], '(PanIN)': [2011], 'A': [2016], 'variety': [2017], 'pathways': [2020, 2372, 3866, 3951, 4053], 'PDAC,': [2028, 2393, 2570, 2574, 2987, 3061], 'most': [2029], 'notably': [2030], 'activating': [2031], 'mutations': [2032], 'KRAS': [2035, 2059, 3087, 3117], 'proto-oncogene,': [2036], 'accounted': [2040], 'formation': [2049], 'progression': [2051, 2249], '(Hidalgo,': [2052], '2010;': [2053], 'Oncogenic': [2058], 'triggers': [2062], 'number': [2064, 2696, 4023], 'downstream': [2066], 'pathways,': [2068], 'Raf/MEK/ERK,': [2070], 'RalGDS/p38': [2071], 'MAPK,': [2072], 'Rac': [2073], 'Rho,': [2075], 'phosphatidylinositide': [2077], '3': [2078, 2288, 3432], '(PI3)': [2079], '(Castellano': [2081], 'Downward,': [2083], '2011),': [2084], 'latter': [2086], 'seems': [2089], 'responsible': [2092], 'majority': [2095], 'KRAS-dependent': [2097], '(Eser': [2100], '2013).': [2103, 2211, 2323], 'Yet,': [2104], 'detailed': [2106], 'underlying': [2109], 'oncogenesis': [2111], 'well': [2113, 2529], 'those': [2115, 3962], 'determining': [2116], 'remarkable': [2118], 'clinically': [2120], 'therapy': [2122], 'are': [2124, 2503, 2880, 2959, 3980], 'understood,': [2127], 'thereby': [2128, 3090], 'measures.': [2135], 'By': [2136], 'wiring': [2137], 'distinct': [2138, 2161, 2198, 3796], 'networks': [2140], 'through': [2141], 'gene-specific': [2142], 'interactions': [2143], 'DNA-binding': [2145], 'transcription': [2146], 'factors,': [2147], 'complexes': [2150, 2231], 'have': [2151, 2297], 'critical': [2155], 'checkpoints': [2156], 'coordination': [2159], 'programs': [2163], '(Spiegelman': [2164], 'Heinrich,': [2166], '2004).': [2167], 'In': [2168, 2439, 3871, 3923, 4010], 'respect,': [2170], 'particularly': [2171], 'differential': [2173, 2457], 'gene': [2174, 4052], 'specific': [2177], 'regulators': [2179], 'between': [2180, 2345, 2735, 2755, 3057], 'healthy': [2181, 2817, 2902], 'conditions': [2184], 'often': [2186], 'reflect': [2190], 'causal,': [2192], 'functional': [2193, 3175], 'role': [2194], 'factors': [2197], 'physiological': [2199], 'pathophysiological': [2201, 2309], 'settings': [2202], '(Berriel': [2203], '2008;': [2207], 'Jones': [2208], 'Based': [2212], 'on': [2213, 2491, 3014, 4094], 'multi-level': [2215], 'dysfunction': [2217, 2349, 2498], 'cancer,': [2220], 'hypothesized': [2222], 'aberrant': [2225, 2300], 'as-yet-not-identified': [2228], 'during': [2232], 'directly': [2235], 'mirrors': [2236], 'tumorigenic': [2238, 3145, 3152, 3304], 'status': [2239], 'contribute': [2246], 'adverse': [2252], 'outcome': [2253], 'disease.': [2256], '(TBL1)': [2260], 'represents': [2261, 3139, 3299], 'initially': [2268, 2385], 'described': [2269, 2803, 4069], 'component': [2272, 3142], 'nuclear': [2275, 2531, 2836, 2845, 2854, 2871, 2918, 2925, 2932, 2939, 2948], 'receptor': [2276], 'co-repressor': [2277], '(NCoR)/silencing': [2278], 'mediator': [2279], 'retinoid': [2281], 'thyroid': [2283], 'receptors': [2284], '(SMRT)/histone': [2285], 'deacetylase': [2286], '(HDAC)': [2287], 'complex': [2289, 2363], '(Guenther': [2290], '2000).': [2293], 'Most': [2294], 'recently,': [2295], 'defined': [2298], 'TBL1/TBLR1': [2303], 'central': [2306], 'lipid': [2310], 'homeostasis': [2311], 'metabolically': [2313], 'active': [2314, 3086], 'tissues': [2315], '(Kulozik': [2316], '2011;': [2319], 'Rohm': [2320], 'Of': [2324, 3274, 4045], 'note,': [2325, 3275, 4046], 'linked': [2330], 'Wnt': [2334], 'pathway': [2336, 3922, 3947], '(Li': [2337], 'Wang,': [2339], '2008).': [2340], 'Given': [2341], 'tight': [2343], 'association': [2344], 'metabolic': [2348, 2371, 2497, 3154, 3319, 3811, 3865, 3902, 4051, 4067], '(Giovannucci': [2350], 'Michaud,': [2352], '2007),': [2353], 'tested': [2356], 'hypothesis': [2358], 'represent': [2365, 4077], 'integrator': [2367], 'proliferative': [2369], 'Results': [2376], 'To': [2384, 2973, 3048], 'explore': [2386, 3173], 'involvement': [2389], 'determined': [2395, 2765, 2798, 3900], 'from': [2405, 2417, 2444, 2548, 2739, 3345, 3414, 3443, 3547, 3590], 'patients': [2406, 2447, 2680, 2722, 2784, 3006], 'who': [2407, 3007], 'had': [2408], 'undergone': [2409], 'surgery': [2410], '(Table': [2413], '1).': [2414], 'Samples': [2415], 'obtained': [2416], 'organ': [2418, 2674, 2731], 'donors': [2419, 2567], 'used': [2421, 2681], 'reference.': [2423], 'detectable': [2428], 'tumor-free': [2430], 'albeit': [2433], 'relatively': [2436], 'low': [2437], 'level.': [2438], 'contrast,': [2440], 'tissue': [2443, 2550, 2759, 2813, 2818, 2892, 2903, 2994, 3115], 'same': [2446, 2741], 'displayed': [2448], '(Fig': [2453, 2557, 3046, 3127, 3225, 3248, 3853, 3905, 3971, 4071], '1A),': [2454], 'suggesting': [2455, 3133, 3296], 'associated': [2462, 2792, 3038], 'and/or': [2465, 3956, 4084], 'staging': [2466], 'humans.': [2468], 'Notably,': [2469], 'neither': [2472], 'observe': [2473], 'influence': [2475], 'body': [2477], 'mass': [2478], 'index': [2479], '(BMI)': [2480], '(<': [2481], '25': [2482, 2573], 'vs.': [2483], '>': [2484], '30': [2485, 2577], 'kg/m2)': [2486], 'nor': [2487], 'chronic': [2489, 2676, 2744], 'pancreatitis': [2490, 2569, 2618, 2625, 2632], 'levels,': [2493], 'indicating': [2494], 'systemic': [2496], 'state': [2502], 'not': [2504, 2703, 2706], 'causative': [2505], 'induction.': [2508], 'Subsequent': [2509], 'histological': [2510], 'examination': [2511], 'demonstrated': [2512, 3218, 4018], 'protein': [2518], 'restricted': [2520], 'neoplastic': [2522], 'epithelial': [2523], 'cytoplasmic': [2527, 2838, 2848, 2873, 2952], 'compartments': [2532], 'but': [2533], 'hardly': [2535], 'detected': [2537], 'other': [2539], 'types': [2541], 'within': [2542], 'gradually': [2546], 'non-malignant': [2549], 'PanIN': [2552, 3125], 'invasive': [2555, 2865, 2942, 3167], '1C;': [2558], 'Supplementary': [2559, 3129, 3252, 3907, 4005], 'Fig': [2560, 3130, 3196, 3253, 3293, 3908, 4006, 4043], 'S1).': [2561], 'Table': [2562, 3973, 4062, 4087], '1.': [2563, 2709], 'Patient': [2564], 'statistics': [2565, 3603, 3675], 'Organ': [2566], 'Chronic': [2568], 'BMI': [2571, 2575, 2639], '≤': [2572], '≥': [2576], 'n': [2578, 2771, 3332, 3401, 3430, 3534, 3577], '8': [2579], '15': [2580, 3851], '9': [2581, 2582], 'Mean': [2583, 2638], 'age': [2584], '±': [2585, 2588, 2591, 2594, 2597, 2640, 2645, 2648, 3785], 'SD': [2586, 2641], '44.25': [2587], '21.45': [2589], '49.50': [2590], '12.52': [2592], '63.89': [2593], '12.42': [2595], '68.44': [2596], '7.88': [2598], 'Male': [2599], '6/8': [2600], '(75%)': [2601], '10/15': [2602], '(66.7%)': [2603, 2661], '4/9': [2604, 2606], '(44.4%)': [2605, 2607], 'Female': [2608], '2/8': [2609], '(25%)': [2610], '5/15': [2611], '(33.3%)': [2612], '5/9': [2613, 2615], '(55.6%)': [2614, 2616], 'Mild': [2617], 'n.a.': [2619, 2622, 2623, 2626, 2629, 2630, 2633, 2636, 2637, 2651, 2652, 2658, 2659, 2665, 2666], '2/15': [2620], '(13.3%)': [2621], 'Medium-severe': [2624], '4/15': [2627], '(26.7%)': [2628], 'Severe': [2631], '9/15': [2634], '(60%)': [2635], 'n.d.': [2642, 2643], '23.04': [2644], '1.42': [2646], '32.33': [2647], '1.52': [2649], 'T3N0M0': [2650], '2/9': [2653, 2669], '(22.2%)': [2654, 2670], '0/9': [2655], '(0%)': [2656], 'T3N1M0': [2657], '6/9': [2660], '7/9': [2662], '(77.8%)': [2663], 'T3N1M1': [2664], '1/9': [2667], '(11.1%)': [2668], 'Statistical': [2671], 'parameters': [2672], 'donors,': [2675], 'pancreatitis,': [2677], 'initial': [2684], 'screen': [2685], 'Figs': [2688], '1A–C': [2689], '3D': [2691], 'E.': [2693], 'n:': [2694], 'total': [2695, 4108, 4112], 'SD:': [2699], 'standard': [2700], 'deviation,': [2701], 'n.a.:': [2702], 'applicable,': [2704], 'n.d.:': [2705], 'determined.': [2707], 'Figure': [2708, 3310], 'individual': [2721], 'normalized': [2723], '18S-rRNA': [2725], 'relative': [2727], 'pooled': [2730], 'donor': [2732], 'sample.': [2733], 'Lines': [2734], 'dots': [2736], 'connect': [2737], 'samples': [2738], 'patient.': [2742], 'CP:': [2743], 'pancreatitis;': [2745], 'PDAC:': [2746, 2786], 'adenocarcinoma;': [2749], 'significant': [2750, 3204], 'difference': [2751], '(P': [2752, 3342, 3411, 3440, 3544, 3587], '<': [2753, 3343, 3412, 3441, 3545, 3588], '0.05)': [2754, 3344, 3413, 3442, 3546, 3589], 'normal': [2758], 'P': [2760], '=': [2761, 2772, 3333, 3402, 3418, 3431, 3535, 3552, 3578], '9.39': [2762], '×': [2763, 3359, 3363, 3367, 3373, 3377, 3381, 3476, 3480, 3484, 3492, 3496, 3500, 3511, 3515, 3608, 3614, 3628, 3634, 3640, 3650, 3656, 3662, 3668, 3680, 3694, 3700, 3706, 3720, 3726, 3732, 3750, 3756, 3762, 3768], '10−5': [2764, 3477, 3485, 3516, 3669, 3727, 3733], 'paired': [2767], 'two-tailed': [2768], "Student's": [2769], 't-test,': [2770], '17': [2773], 'patients.': [2774], 'Association': [2775], 'microarray-based': [2777], '105': [2783, 3005], 'High': [2787], 'significantly': [2791, 3037, 3287, 3340, 3409, 3438, 3585], 'shorter': [2794], 'post-resection': [2795, 3040], 'survival.': [2796], 'P-value': [2797, 4106], 'log-rank': [2800], 'test': [2801, 3049, 3566, 3808], '4.': [2805], 'Immunohistochemistry': [2806, 2886], 'staining': [2807, 2887], 'paraffin-embedded': [2812, 2891], 'sections.': [2814], '1,': [2815, 2900], '2:': [2816, 2901], 'acini': [2820], 'duct': [2822, 2910], 'showing': [2823, 2915], 'no': [2824, 4047], 'very': [2827], 'weak': [2828, 2917], 'staining.': [2829, 2839, 2849, 2862, 2874, 2919, 2926, 2933, 2940, 2953], '3,': [2830, 2920], '4:': [2831, 2921], 'PanIN-1': [2832, 2922], 'occasional': [2835, 2847, 2916, 2950], '5,': [2840, 2927, 3684, 3714, 3740], '6:': [2841, 2928], 'PanIN-2': [2842, 2929], 'lesion': [2843, 2852, 2937], '7–10:': [2850], 'PanIN-3': [2851, 2936], 'occurrence': [2857], 'intensity': [2859], 'cytoplasmatic': [2861], '11,': [2863], '12:': [2864], 'Scale': [2875, 2954], 'bars:': [2876, 2955], '100': [2877, 2956], 'μm.': [2878, 2957], 'Images': [2879, 2958], 'representative': [2881, 2960], '12': [2883], 'patient': [2884], 'samples.': [2885], 'sections': [2893], 'wild-type': [2895, 2963], 'p48+/Cre;': [2897, 2966, 3064], 'Kras+/LSL-G12D': [2898, 2967, 3065], 'mice.': [2899, 2968, 3066], 'acini,': [2905], 'islet': [2906], 'Langerhans,': [2908], '(zoom-in': [2911], 'panel': [2913], '2)': [2914], '7,': [2934, 3692, 3748], '8:': [2935], '9–12:': [2941], 'faint': [2951], '32': [2962], '29': [2965], 'Download': [2969, 2971, 3787, 3789], 'figure': [2970, 3788], 'PowerPoint': [2972, 3790], 'validate': [2974], 'findings': [2976], 'assess': [2979], 'clinical': [2982], 'relevance': [2983], 'analyzed': [2989], 'respect': [2996], 'independent': [3002], 'underwent': [3008], 'resection': [3009], 'Intriguingly,': [3012], 'based': [3013], 'genome-wide': [3015], 'transcriptome': [3016, 3941], 'analysis': [3017, 3904, 3942, 4016, 4090], 'after': [3019, 3842], 'adjustment': [3020], 'effects': [3022], 'variable': [3024], 'content': [3027], 'biopsies': [3030], 'subjects': [3045], '1B).': [3047], 'whether': [3050], 'upregulation': [3052, 3162], 'conserved': [3055, 3141, 3262], 'feature': [3056], 'employed': [3063], 'These': [3067, 3855], 'animals': [3068, 3119], 'develop': [3069], 'pre-cancerous': [3070], 'eventually': [3073], 'tumors': [3075], 'due': [3079], 'organ-specific': [3081], 'constitutively': [3085], 'small': [3088], 'GTPase,': [3089], 'closely': [3091], 'mimicking': [3092], 'pathology': [3095], '(Hingorani': [3096], '2003).': [3099], 'Similar': [3100], 'our': [3102], 'observations': [3103], 'humans,': [3105], 'expressed': [3112], 'mutant': [3118], 'enrichment': [3122, 4114], '1D;': [3128], 'S2),': [3131], 'up-regulation': [3136], 'program': [3146, 3305], 'adaptations': [3155, 3320, 3812], 'marked': [3161], 'next': [3169, 3926], 'prompted': [3170, 3804], 'us': [3171, 3805], 'importance': [3176], 'properties.': [3183], 'siRNA-mediated': [3184], 'knockdown': [3185, 3233, 3276, 4036, 4093], '(Capan-1)': [3193], '(Supplementary': [3195, 3292, 4042, 4061], 'S3A,': [3197], 'C': [3198], 'D)': [3200, 4074], 'led': [3201], 'reduction': [3205], 'numbers': [3211], 'compared': [3212, 4038], 'control': [3214, 3346, 3415, 3444, 3548, 3591, 4040], 'siRNA-transfected': [3215, 3326, 3425, 3528, 3560], 'EdU': [3220, 3323, 3391], 'incorporation': [3221, 3324, 3392, 3846], 'counting': [3224], '2A': [3226, 3249], 'B).': [3228, 4009], 'Importantly,': [3229], 'siRNA-': [3230], 'shRNA-mediated': [3232], '(Panc02': [3241], 'Panc8680)': [3243], 'B;': [3251], 'S3B),': [3254], 'underlining': [3255], 'conclusion': [3257], 'fulfills': [3260], 'regulatory': [3264], 'function': [3265], 'cells.': [3273, 3309, 3821, 3870, 3945], 'impaired': [3288], 'invasiveness': [3291], 'S4),': [3294], '2.': [3311, 4088], 'Left': [3321], 'panel:': [3322, 3390], 'Capan-1': [3327, 3426, 3455, 3470, 3529, 3561, 3829, 3883, 3944], '(72': [3329], 'h': [3330, 3458, 3473, 3508, 3532, 3569, 3841], 'post-transfection),': [3331], '6': [3334, 3403, 3536], 'culture': [3336, 3405, 3434, 3538, 3581], 'wells': [3337, 3406, 3435, 3539, 3582], 'per': [3338, 3407, 3436, 3540, 3583], 'group;': [3339, 3408, 3437, 3541, 3584], 'different': [3341, 3410, 3439, 3543, 3586], '(no': [3347, 3445, 3592], 'siRNA)': [3348, 3446, 3593], '*,': [3349, 3447, 3594], 'siNC': [3350, 3353, 3448, 3451, 3595, 3598], '#1': [3351, 3449, 3464, 3489, 3596], '#,': [3352, 3450, 3597], '#2': [3354, 3371, 3452], '$;': [3355, 3453], 'P-values:': [3356, 3454, 3606, 3678], 'siTBL1#1': [3357], '8.24': [3358], '10−4': [3360, 3364, 3512, 3635, 3641], '(*),': [3361, 3375, 3478, 3494, 3513], '5.43': [3362], '(#),': [3365, 3379, 3482, 3498], '7.93': [3366], '10−6': [3368, 3629, 3657, 3663, 3721], '($);': [3369, 3517], 'siTBL1': [3370, 3463, 3468, 3488, 3504], '1.66': [3372], '10−11': [3374, 3378], '1.27': [3376, 3699], '8.79': [3380], '10−13': [3382], '($),': [3383], 'one-way': [3384], 'ANOVA': [3385, 3519, 3774], 'Bonferroni': [3387, 3521, 3776, 4115], 'post-test.': [3388, 3522, 3777], 'Right': [3389], 'Panc02': [3394], 'stable': [3397], 'shRNA;': [3400], '(shNC)': [3416], '#P': [3417], '0.0398;': [3419], "Welch's": [3420, 3554], 't-test.': [3421, 3555], 'Cell': [3422, 4120, 4147, 4161], 'Panc8680': [3428, 3506], 'cells;': [3429], '48': [3457, 3840], 'time-point:': [3459, 3474, 3509], '0.0408': [3460], '(*)': [3461, 3610, 3616, 3620, 3624, 3682, 3686, 3690, 3696, 3702, 3708], '/': [3465, 3490], '0.0464': [3466], '#2,': [3469], '72': [3472, 3507], '8.60': [3475], '1.82': [3479], '10−3': [3481, 3609, 3615, 3681, 3695, 3701, 3707, 3769], '3.24': [3483], '($)': [3486, 3502, 3652, 3658, 3664, 3670, 3738, 3742, 3746, 3752, 3758, 3764, 3770], '2.39': [3491], '10−10': [3493, 3501], '3.34': [3495], '10−9': [3497], '1.08': [3499], '#2;': [3505], '1.55': [3510], '2.73': [3514], 'two-way': [3518], 'Uptake': [3523], 'radio-labeled': [3525, 3848], '3H-2-deoxyglucose': [3526], '(48': [3531, 3568], 'post-transfection);': [3533, 3570], 'statistically': [3542], '(siNC': [3549], '#2)': [3550, 3599], '$P': [3551], '0.03;': [3553], 'Extracellular': [3556], 'flux': [3557, 3903], 'measurement': [3558], 'glycolysis': [3564], 'stress': [3565], 'assay': [3567], '2-DG:': [3571], '2-deoxyglucose;': [3572], 'ECAR:': [3573], 'extracellular': [3574], 'acidification': [3575], 'rate.': [3576], '6–8': [3579], '$.': [3600], 'Upper': [3601], 'symbols:': [3602, 3674], 'siTBL#1,': [3605], '2.18': [3607], 'time-point': [3611, 3617, 3621, 3625, 3631, 3637, 3643, 3647, 3653, 3659, 3665, 3671, 3683, 3687, 3691, 3697, 3703, 3709, 3713, 3717, 3723, 3729, 3735, 3739, 3743, 3747, 3753, 3759, 3765, 3771], '8,': [3612, 3632, 3654, 3698, 3724, 3754], '9.83': [3613], '9,': [3618, 3638, 3660, 3704, 3730, 3760], '0.0102': [3619], '10,': [3622, 3644, 3666, 3766], '0.044': [3623], '11;': [3626, 3648], '2.42': [3627], '(#)': [3630, 3636, 3642, 3646, 3712, 3716, 3722, 3728, 3734], '1.47': [3633], '3.17': [3639], '0.0277': [3645], '9.44': [3649], '10−7': [3651, 3751, 3763], '1.23': [3655], '1.33': [3661], '7.14': [3667], '11.': [3672, 3772], 'Lower': [3673], 'siTBL#2,': [3677], '3.94': [3679], '0.0143': [3685], '6,': [3688, 3718, 3744], '0.0342': [3689], '1.45': [3693], '2.38': [3705], '10;': [3710, 3736], '0.01': [3711], '0.0362': [3715], '1.22': [3719], '1.28': [3725], '5.84': [3731], '0.0118': [3737], '0.0208': [3741], '0.0291': [3745], '4.52': [3749], '6.04': [3755], '10−8': [3757], '1.43': [3761], '4.83': [3767, 4151], 'Two-way': [3773], 'Data': [3778], 'information:': [3779], 'All': [3780], 'data': [3781], 'plotted': [3782], 'mean': [3784], 'SEM.': [3786], 'Rapidly': [3791], 'proliferating': [3792], 'display': [3795], 'nutrient': [3797], 'liabilities': [3798], '(Ward': [3799], 'Thompson,': [3801], '2012),': [3802], 'siRNA': [3826], 'delivery': [3827], 'uptake': [3835], '30%': [3837], 'measured': [3839], 'transfection': [3843], 'monitoring': [3845], '2-deoxyglucose': [3849], 'over': [3850], 'min': [3852], '2C).': [3854], 'experiments': [3856], 'suggested': [3857], 'couple': [3861], 'proliferative,': [3862], 'invasive,': [3863], 'agreement': [3872], 'supply': [3878], 'upon': [3879, 4034], 'deficiency,': [3881], 'TBL1-depleted': [3882], 'usage,': [3888], 'while': [3889], 'mitochondrial': [3890, 3894], 'oxidative': [3891], 'phosphorylation': [3892], 'ATP': [3895], 'production': [3896], 'remained': [3897], 'unchanged': [3898], '2D;': [3906], 'S5).': [3909], 'upstream': [3914], 'activator': [3916], 'kinase-dependent': [3920], 'order': [3924], 'determine': [3927], 'action': [3933], 'cells,': [3937], 'performed': [3939], 'high-throughput': [3940], 'using': [3943], 'Genetic': [3946], 'determination': [3948], 'revealed': [3949], 'involved': [3952], 'cycle': [3958, 4121, 4135, 4148, 4162, 4179], 'over-represented': [3960], 'among': [3961], 'differentially': [3963], 'regulated': [3964], '3A,': [3972], '2).': [3974], 'Indeed,': [3975], 'CDK2': [3976], 'CDK4,': [3978], 'important': [3981], 'G1/S-phase': [3983], 'transition': [3984], 'G1': [3986], 'phase': [3987, 4149], 'progression,': [3988], 'respectively,': [3989], 'following': [3992], 'ablation': [3993], '(Figs': [4001], '3B': [4002], '5;': [4004], 'S6A': [4007], 'line': [4011], 'findings,': [4014], 'FACS': [4015], 'indeed': [4017], 'decrease': [4020], 'S-phase': [4027], 'concomitant': [4030], 'increase': [4031], 'G0/G1': [4033], 'S7).': [4044], 'major': [4048], 'change': [4049], 'observed': [4055], 'S1),': [4063], 'implying': [4064], 'alterations': [4068, 4081], 'above': [4070], '2C': [4072], 'secondary': [4078], 'consequences': [4079], 'growth.': [4086], 'Over-representation': [4089], 'GOPB': [4095], 'terms': [4096], 'Annotation': [4097], 'cluster': [4098], 'Enrichment': [4100], 'score:': [4101], '4.0244': [4102], 'Term': [4103], 'Count': [4104], '%': [4105], 'List': [4107], 'Pop': [4109, 4111], 'hits': [4110], 'Fold': [4113], 'Benjamini': [4116], 'FDR': [4117], '[%]': [4118], 'GO:0007049': [4119], '71': [4122], '8.17': [4123], '8.05E-08': [4124], '635': [4125, 4139, 4153, 4167, 4183], '776': [4126], '13,528': [4127, 4141, 4155, 4169], '1.949': [4128], '2.18E-04': [4129, 4130], '1.43E-04': [4131], 'GO:0000278': [4132], 'Mitotic': [4133], '39': [4136], '4.49': [4137], '4.61E-06': [4138], '370': [4140], '2.246': [4142], '0.012382': [4143], '0.006210': [4144], '0.008198': [4145], 'GO:0022403': [4146], '42': [4150], '4.82E-06': [4152], '414': [4154], '2.161': [4156], '0.012942': [4157], '0.004333': [4158], '0.008571': [4159], 'GO:0022402': [4160], '52': [4164], '5.98': [4165], '5.15E-06': [4166], '565': [4168], '1.961': [4170], '0.013830': [4171], '0.003476': [4172], '0.009163': [4173], 'GO:0051329': [4174], 'Interphase': [4175], 'mitotic': [4177], '16': [4180], '1.84': [4181], '8.65E-05': [4182]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2133539045', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 3}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 2}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 1}], 'updated_date': '2024-12-11T07:22:18.508925', 'created_date': '2016-06-24'}
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