Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2133438218', 'doi': 'https://doi.org/10.1081/iph-120014727', 'title': 'MODULATION OF ANTIGEN-SPECIFIC IMMUNE RESPONSES BY THE ORAL ADMINISTRATION OF A TRADITIONAL MEDICINE, BO-YANG-HWAN-O-TANG', 'display_name': 'MODULATION OF ANTIGEN-SPECIFIC IMMUNE RESPONSES BY THE ORAL ADMINISTRATION OF A TRADITIONAL MEDICINE, BO-YANG-HWAN-O-TANG', 'publication_year': 2002, 'publication_date': '2002-01-01', 'ids': {'openalex': 'https://openalex.org/W2133438218', 'doi': 'https://doi.org/10.1081/iph-120014727', 'mag': '2133438218', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/12375738'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1081/iph-120014727', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S16829457', 'display_name': 'Immunopharmacology and Immunotoxicology', 'issn_l': '0892-3973', 'issn': ['0892-3973', '1532-2513'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100644142', 'display_name': 'Eunha Kim', 'orcid': 'https://orcid.org/0000-0001-7041-1727'}, 'institutions': [{'id': 'https://openalex.org/I80611190', 'display_name': 'Jeonbuk National University', 'ror': 'https://ror.org/05q92br09', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I80611190']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Eun-Ha Kim', 'raw_affiliation_strings': ['Division of Biological Sciences and The Institute for Molecular Biology and Genetics, Chonbuk National University, Chonju, 561-756, Korea'], 'affiliations': [{'raw_affiliation_string': 'Division of Biological Sciences and The Institute for Molecular Biology and Genetics, Chonbuk National University, Chonju, 561-756, Korea', 'institution_ids': ['https://openalex.org/I80611190']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044518854', 'display_name': 'Jeong‐Chae Lee', 'orcid': 'https://orcid.org/0000-0002-4340-7965'}, 'institutions': [{'id': 'https://openalex.org/I80611190', 'display_name': 'Jeonbuk National University', 'ror': 'https://ror.org/05q92br09', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I80611190']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Jeong-Chae Lee', 'raw_affiliation_strings': ['Division of Biological Sciences and The Institute for Molecular Biology and Genetics, Chonbuk National University, Chonju, 561-756, Korea'], 'affiliations': [{'raw_affiliation_string': 'Division of Biological Sciences and The Institute for Molecular Biology and Genetics, Chonbuk National University, Chonju, 561-756, Korea', 'institution_ids': ['https://openalex.org/I80611190']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081828653', 'display_name': 'Ju Kim', 'orcid': 'https://orcid.org/0000-0002-6190-6506'}, 'institutions': [{'id': 'https://openalex.org/I80611190', 'display_name': 'Jeonbuk National University', 'ror': 'https://ror.org/05q92br09', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I80611190']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Ju Kim', 'raw_affiliation_strings': ['Bank for Cytokine Research, Chonbuk National University, Chonju, 561-756, Korea', 'Division of Biological Sciences and The Institute for Molecular Biology and Genetics, Chonbuk National University, Chonju, 561-756, Korea'], 'affiliations': [{'raw_affiliation_string': 'Bank for Cytokine Research, Chonbuk National University, Chonju, 561-756, Korea', 'institution_ids': ['https://openalex.org/I80611190']}, {'raw_affiliation_string': 'Division of Biological Sciences and The Institute for Molecular Biology and Genetics, Chonbuk National University, Chonju, 561-756, Korea', 'institution_ids': ['https://openalex.org/I80611190']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085273502', 'display_name': 'Young‐Ok Son', 'orcid': 'https://orcid.org/0000-0003-0154-4061'}, 'institutions': [{'id': 'https://openalex.org/I111277659', 'display_name': 'Chonnam National University', 'ror': 'https://ror.org/05kzjxq56', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I111277659']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Young-Ok Son', 'raw_affiliation_strings': ['Molecular Biochemistry Lab. & Biodefensive Substances Group, Institute of Biotechnology, Chonnam National University, Kwangju, 500-757, Korea'], 'affiliations': [{'raw_affiliation_string': 'Molecular Biochemistry Lab. & Biodefensive Substances Group, Institute of Biotechnology, Chonnam National University, Kwangju, 500-757, Korea', 'institution_ids': ['https://openalex.org/I111277659']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089491732', 'display_name': 'Gook‐Hyun Chung', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I80611190', 'display_name': 'Jeonbuk National University', 'ror': 'https://ror.org/05q92br09', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I80611190']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Gook-Hyun Chung', 'raw_affiliation_strings': ['Bank for Cytokine Research, Chonbuk National University, Chonju, 561-756, Korea', 'Division of Biological Sciences and The Institute for Molecular Biology and Genetics, Chonbuk National University, Chonju, 561-756, Korea'], 'affiliations': [{'raw_affiliation_string': 'Division of Biological Sciences and The Institute for Molecular Biology and Genetics, Chonbuk National University, Chonju, 561-756, Korea', 'institution_ids': ['https://openalex.org/I80611190']}, {'raw_affiliation_string': 'Bank for Cytokine Research, Chonbuk National University, Chonju, 561-756, Korea', 'institution_ids': ['https://openalex.org/I80611190']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5030863704', 'display_name': 'Yong‐Suk Jang', 'orcid': 'https://orcid.org/0000-0002-1675-4224'}, 'institutions': [{'id': 'https://openalex.org/I80611190', 'display_name': 'Jeonbuk National University', 'ror': 'https://ror.org/05q92br09', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I80611190']}], 'countries': ['KR'], 'is_corresponding': False, 'raw_author_name': 'Yong-Suk Jang', 'raw_affiliation_strings': ['Bank for Cytokine Research, Chonbuk National University, Chonju, 561-756, Korea', 'Division of Biological Sciences and The Institute for Molecular Biology and Genetics, Chonbuk National University, Chonju, 561-756, Korea'], 'affiliations': [{'raw_affiliation_string': 'Bank for Cytokine Research, Chonbuk National University, Chonju, 561-756, Korea', 'institution_ids': ['https://openalex.org/I80611190']}, {'raw_affiliation_string': 'Division of Biological Sciences and The Institute for Molecular Biology and Genetics, Chonbuk National University, Chonju, 561-756, Korea', 'institution_ids': ['https://openalex.org/I80611190']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.505, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 18, 'citation_normalized_percentile': {'value': 0.573075, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 84, 'max': 85}, 'biblio': {'volume': '24', 'issue': '3', 'first_page': '423', 'last_page': '440'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11020', 'display_name': 'Immune Cell Function and Interaction', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10943', 'display_name': 'Escherichia coli research studies', 'score': 0.9957, 'subfield': {'id': 'https://openalex.org/subfields/1310', 'display_name': 'Endocrinology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11155', 'display_name': 'Toxoplasma gondii Research Studies', 'score': 0.9864, 'subfield': {'id': 'https://openalex.org/subfields/2405', 'display_name': 'Parasitology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/splenocyte', 'display_name': 'Splenocyte', 'score': 0.6027366}, {'id': 'https://openalex.org/keywords/priming', 'display_name': 'Priming (agriculture)', 'score': 0.45124623}], 'concepts': [{'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.80815905}, {'id': 'https://openalex.org/C147483822', 'wikidata': 'https://www.wikidata.org/wiki/Q103537', 'display_name': 'Antigen', 'level': 2, 'score': 0.6893569}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.60894454}, {'id': 'https://openalex.org/C189976730', 'wikidata': 'https://www.wikidata.org/wiki/Q3493700', 'display_name': 'Splenocyte', 'level': 3, 'score': 0.6027366}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.52312535}, {'id': 'https://openalex.org/C2908647359', 'wikidata': 'https://www.wikidata.org/wiki/Q2625603', 'display_name': 'Population', 'level': 2, 'score': 0.45584694}, {'id': 'https://openalex.org/C81444415', 'wikidata': 'https://www.wikidata.org/wiki/Q7243535', 'display_name': 'Priming (agriculture)', 'level': 3, 'score': 0.45124623}, {'id': 'https://openalex.org/C24998067', 'wikidata': 'https://www.wikidata.org/wiki/Q4114622', 'display_name': 'Stimulation', 'level': 2, 'score': 0.43270355}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.42180485}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3296016}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.15199068}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C100701293', 'wikidata': 'https://www.wikidata.org/wiki/Q193838', 'display_name': 'Germination', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C99454951', 'wikidata': 'https://www.wikidata.org/wiki/Q932068', 'display_name': 'Environmental health', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000276', 'descriptor_name': 'Adjuvants, Immunologic', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D008518', 'descriptor_name': 'Medicine, East Asian Traditional', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000276', 'descriptor_name': 'Adjuvants, Immunologic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000284', 'descriptor_name': 'Administration, Oral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000917', 'descriptor_name': 'Antibody Formation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000917', 'descriptor_name': 'Antibody Formation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004527', 'descriptor_name': 'Egg Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004527', 'descriptor_name': 'Egg Proteins', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007371', 'descriptor_name': 'Interferon-gamma', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D015847', 'descriptor_name': 'Interleukin-4', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015847', 'descriptor_name': 'Interleukin-4', 'qualifier_ui': 'Q000096', 'qualifier_name': 'biosynthesis', 'is_major_topic': False}, {'descriptor_ui': 'D007723', 'descriptor_name': 'Korea', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008213', 'descriptor_name': 'Lymphocyte Activation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008213', 'descriptor_name': 'Lymphocyte Activation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009113', 'descriptor_name': 'Muramidase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009113', 'descriptor_name': 'Muramidase', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1081/iph-120014727', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S16829457', 'display_name': 'Immunopharmacology and Immunotoxicology', 'issn_l': '0892-3973', 'issn': ['0892-3973', '1532-2513'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320547', 'host_organization_name': 'Taylor & Francis', 'host_organization_lineage': ['https://openalex.org/P4310320547'], 'host_organization_lineage_names': ['Taylor & Francis'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/12375738', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.81}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W1551647859', 'https://openalex.org/W1575299903', 'https://openalex.org/W1598189172', 'https://openalex.org/W1765588280', 'https://openalex.org/W1942668068', 'https://openalex.org/W1990882452', 'https://openalex.org/W1993596576', 'https://openalex.org/W2003126462', 'https://openalex.org/W2007884447', 'https://openalex.org/W2013595164', 'https://openalex.org/W2016738669', 'https://openalex.org/W2022517847', 'https://openalex.org/W2023466603', 'https://openalex.org/W2025340024', 'https://openalex.org/W2029836713', 'https://openalex.org/W2030186991', 'https://openalex.org/W2030261077', 'https://openalex.org/W2035104903', 'https://openalex.org/W2059333433', 'https://openalex.org/W2063126884', 'https://openalex.org/W2065997849', 'https://openalex.org/W2074602523', 'https://openalex.org/W2076376959', 'https://openalex.org/W2078034183', 'https://openalex.org/W2079967754', 'https://openalex.org/W2089911206', 'https://openalex.org/W2102235987', 'https://openalex.org/W2219562258', 'https://openalex.org/W2407392029', 'https://openalex.org/W2410303910', 'https://openalex.org/W981195140'], 'related_works': ['https://openalex.org/W4378965535', 'https://openalex.org/W3032001543', 'https://openalex.org/W2406010984', 'https://openalex.org/W2401172966', 'https://openalex.org/W2371628387', 'https://openalex.org/W2364406978', 'https://openalex.org/W2362675350', 'https://openalex.org/W2119506352', 'https://openalex.org/W2057712953', 'https://openalex.org/W1971274279'], 'abstract_inverted_index': {'Bo-yang-hwan-o-tang': [0], '(BHT)': [1], 'has': [2], 'long': [3], 'been': [4], 'used': [5, 181], 'to': [6, 16, 62], 'treat': [7], 'cancer': [8], 'in': [9, 56, 136, 139], 'traditional': [10], 'Korean': [11], 'medicine': [12], 'and': [13, 52, 88, 178], 'is': [14], 'believed': [15], 'have': [17], 'immune-modulating': [18], 'activity.': [19], 'This': [20, 101, 131, 153], 'study': [21], 'investigated': [22], 'the': [23, 28, 63, 76, 85, 95, 112, 127, 141], 'effect': [24], 'of': [25, 30, 46, 84, 98, 115, 123, 126, 143, 150, 165], 'BHT': [26, 47, 61, 78, 104, 144, 173], 'on': [27], 'induction': [29], 'antigen-specific': [31, 175], 'immune': [32, 109, 176, 191], 'responses': [33, 55, 110], 'using': [34], 'hen': [35], 'egg-white': [36], 'lysozyme': [37], '(HEL)': [38], 'as': [39, 182], 'a': [40, 159, 162, 183], 'model': [41], 'antigen': [42], 'system.': [43], 'Oral': [44], 'administration': [45], 'enhanced': [48, 190], 'both': [49], 'HEL-specific': [50, 82], 'humoral': [51, 108], 'lymphocyte': [53], 'proliferative': [54], 'HEL': [57], 'low-responder': [58], 'mice.': [59], 'Feeding': [60], 'mice': [64], 'increased': [65, 81], 'INF-γ': [66], 'levels,': [67], 'but': [68], 'did': [69], 'not': [70], 'change': [71], 'IL-4': [72], 'levels.': [73], 'Interestingly,': [74], 'however,': [75], 'oral': [77], 'feeding': [79], 'significantly': [80, 145], 'antibodies': [83], 'IgG1,': [86], 'IgG2b,': [87], 'IgG3': [89], 'subtypes,': [90], 'which': [91, 140], 'are': [92], 'associated': [93, 157], 'with': [94, 158, 161], 'direct': [96, 113], 'stimulation': [97, 114], 'B': [99, 116], 'cells.': [100], 'indicates': [102], 'that': [103, 172], 'treatment': [105], 'enhances': [106], 'anti-HEL-specific': [107], 'via': [111], 'lymphocytes': [117], 'rather': [118], 'than': [119], 'by': [120, 135], 'selective': [121], 'priming': [122], 'specific': [124], 'subtypes': [125], 'helper': [128], 'T-cell': [129], 'population.': [130], 'conclusion': [132], 'was': [133, 155], 'supported': [134], 'vitro': [137], 'experiments,': [138], 'presence': [142], 'augmented': [146], 'B-cell': [147], 'mitogen-mediated': [148], 'proliferation': [149], 'mouse': [151], 'splenocytes.': [152], 'augmentation': [154], 'closely': [156], 'glycoprotein': [160], 'molecular': [163], 'weight': [164], 'around': [166], '100': [167], 'kDa.': [168], 'The': [169], 'results': [170], 'suggest': [171], 'modulates': [174], 'responses,': [177], 'might': [179], 'be': [180], 'therapeutic': [184], 'agent': [185], 'for': [186], 'patients': [187], 'who': [188], 'need': [189], 'function.': [192]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2133438218', 'counts_by_year': [{'year': 2020, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 1}, {'year': 2012, 'cited_by_count': 3}], 'updated_date': '2024-12-16T08:14:51.690009', 'created_date': '2016-06-24'}