Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2132941431', 'doi': 'https://doi.org/10.1104/pp.126.1.445', 'title': 'Dissecting the Superoxide Dismutase-Ascorbate-Glutathione-Pathway in Chloroplasts by Metabolic Modeling. Computer Simulations as a Step towards Flux Analysis', 'display_name': 'Dissecting the Superoxide Dismutase-Ascorbate-Glutathione-Pathway in Chloroplasts by Metabolic Modeling. Computer Simulations as a Step towards Flux Analysis', 'publication_year': 2001, 'publication_date': '2001-05-01', 'ids': {'openalex': 'https://openalex.org/W2132941431', 'doi': 'https://doi.org/10.1104/pp.126.1.445', 'mag': '2132941431', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/11351106', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/102317'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1104/pp.126.1.445', 'pdf_url': 'https://academic.oup.com/plphys/article-pdf/126/1/445/38680158/plphys_v126_1_445.pdf', 'source': {'id': 'https://openalex.org/S42294715', 'display_name': 'PLANT PHYSIOLOGY', 'issn_l': '0032-0889', 'issn': ['0032-0889', '1532-2548'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://academic.oup.com/plphys/article-pdf/126/1/445/38680158/plphys_v126_1_445.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5014052089', 'display_name': 'Andrea Polle', 'orcid': 'https://orcid.org/0000-0001-8697-6394'}, 'institutions': [{'id': 'https://openalex.org/I4210151128', 'display_name': 'IGES Institut', 'ror': 'https://ror.org/04qchsx62', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210151128']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Andrea Polle', 'raw_affiliation_strings': ['Georg-August Universitaet, Forstbotanisches Institut, Abteilung I, Forstbotanik und Baumphysiologie, Buesgenweg 2, 37077 Goettingen, Germany.'], 'affiliations': [{'raw_affiliation_string': 'Georg-August Universitaet, Forstbotanisches Institut, Abteilung I, Forstbotanik und Baumphysiologie, Buesgenweg 2, 37077 Goettingen, Germany.', 'institution_ids': ['https://openalex.org/I4210151128']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5014052089'], 'corresponding_institution_ids': ['https://openalex.org/I4210151128'], 'apc_list': {'value': 3411, 'currency': 'USD', 'value_usd': 3411, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 4.934, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 416, 'citation_normalized_percentile': {'value': 0.999974, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '126', 'issue': '1', 'first_page': '445', 'last_page': '462'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10303', 'display_name': 'Photosynthetic Processes and Mechanisms', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10303', 'display_name': 'Photosynthetic Processes and Mechanisms', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T13013', 'display_name': 'Free Radicals and Antioxidants', 'score': 0.9834, 'subfield': {'id': 'https://openalex.org/subfields/1605', 'display_name': 'Organic Chemistry'}, 'field': {'id': 'https://openalex.org/fields/16', 'display_name': 'Chemistry'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10014', 'display_name': 'Plant Stress Responses and Tolerance', 'score': 0.9808, 'subfield': {'id': 'https://openalex.org/subfields/1110', 'display_name': 'Plant Science'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/glutathione-reductase', 'display_name': 'Glutathione reductase', 'score': 0.84793484}], 'concepts': [{'id': 'https://openalex.org/C165069038', 'wikidata': 'https://www.wikidata.org/wiki/Q420930', 'display_name': 'Glutathione reductase', 'level': 5, 'score': 0.84793484}, {'id': 'https://openalex.org/C538909803', 'wikidata': 'https://www.wikidata.org/wiki/Q116907', 'display_name': 'Glutathione', 'level': 3, 'score': 0.7699677}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.70225656}, {'id': 'https://openalex.org/C2775838275', 'wikidata': 'https://www.wikidata.org/wiki/Q410776', 'display_name': 'Superoxide dismutase', 'level': 3, 'score': 0.648949}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.61780655}, {'id': 'https://openalex.org/C2778004101', 'wikidata': 'https://www.wikidata.org/wiki/Q133948', 'display_name': 'Antioxidant', 'level': 2, 'score': 0.5864576}, {'id': 'https://openalex.org/C134651460', 'wikidata': 'https://www.wikidata.org/wiki/Q3100717', 'display_name': 'Reductase', 'level': 3, 'score': 0.5746591}, {'id': 'https://openalex.org/C2778760513', 'wikidata': 'https://www.wikidata.org/wiki/Q24773045', 'display_name': 'Glutathione peroxidase', 'level': 4, 'score': 0.54534626}, {'id': 'https://openalex.org/C55904794', 'wikidata': 'https://www.wikidata.org/wiki/Q82682', 'display_name': 'Redox', 'level': 2, 'score': 0.53892684}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.52343917}, {'id': 'https://openalex.org/C68709404', 'wikidata': 'https://www.wikidata.org/wiki/Q1134475', 'display_name': 'Flux (metallurgy)', 'level': 2, 'score': 0.51175356}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.24113548}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.058685422}], 'mesh': [{'descriptor_ui': 'D001205', 'descriptor_name': 'Ascorbic Acid', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002736', 'descriptor_name': 'Chloroplasts', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D003198', 'descriptor_name': 'Computer Simulation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005978', 'descriptor_name': 'Glutathione', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D001205', 'descriptor_name': 'Ascorbic Acid', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002736', 'descriptor_name': 'Chloroplasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002736', 'descriptor_name': 'Chloroplasts', 'qualifier_ui': 'Q000201', 'qualifier_name': 'enzymology', 'is_major_topic': False}, {'descriptor_ui': 'D005978', 'descriptor_name': 'Glutathione', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017382', 'descriptor_name': 'Reactive Oxygen Species', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013482', 'descriptor_name': 'Superoxide Dismutase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1104/pp.126.1.445', 'pdf_url': 'https://academic.oup.com/plphys/article-pdf/126/1/445/38680158/plphys_v126_1_445.pdf', 'source': {'id': 'https://openalex.org/S42294715', 'display_name': 'PLANT PHYSIOLOGY', 'issn_l': '0032-0889', 'issn': ['0032-0889', '1532-2548'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://resolver.sub.uni-goettingen.de/purl?gs-1/7444', 'pdf_url': 'https://publications.goettingen-research-online.de/bitstream/2/15634/1/Plant_Physiology.pdf', 'source': {'id': 'https://openalex.org/S4306401634', 'display_name': 'GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I4210122495', 'host_organization_name': 'Asklepios Klinik St. Georg', 'host_organization_lineage': ['https://openalex.org/I4210122495'], 'host_organization_lineage_names': ['Asklepios Klinik St. Georg'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC102317', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/11351106', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1104/pp.126.1.445', 'pdf_url': 'https://academic.oup.com/plphys/article-pdf/126/1/445/38680158/plphys_v126_1_445.pdf', 'source': {'id': 'https://openalex.org/S42294715', 'display_name': 'PLANT PHYSIOLOGY', 'issn_l': '0032-0889', 'issn': ['0032-0889', '1532-2548'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/6', 'score': 0.56, 'display_name': 'Clean water and sanitation'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 66, 'referenced_works': ['https://openalex.org/W122125369', 'https://openalex.org/W137776434', 'https://openalex.org/W1497895255', 'https://openalex.org/W151452226', 'https://openalex.org/W1556016100', 'https://openalex.org/W1557981728', 'https://openalex.org/W1564781685', 'https://openalex.org/W1568785156', 'https://openalex.org/W1569815200', 'https://openalex.org/W1584077814', 'https://openalex.org/W165303406', 'https://openalex.org/W1750990940', 'https://openalex.org/W1872812400', 'https://openalex.org/W1922228235', 'https://openalex.org/W1964519487', 'https://openalex.org/W1967316460', 'https://openalex.org/W1968392253', 'https://openalex.org/W1970694255', 'https://openalex.org/W1973712759', 'https://openalex.org/W1980945992', 'https://openalex.org/W1981667404', 'https://openalex.org/W1984970586', 'https://openalex.org/W1993015950', 'https://openalex.org/W1995327418', 'https://openalex.org/W1998391472', 'https://openalex.org/W1999876250', 'https://openalex.org/W2001272842', 'https://openalex.org/W2006964554', 'https://openalex.org/W2009074963', 'https://openalex.org/W2009623212', 'https://openalex.org/W2012190292', 'https://openalex.org/W2030157501', 'https://openalex.org/W2037763413', 'https://openalex.org/W2038749103', 'https://openalex.org/W2043892446', 'https://openalex.org/W2046938998', 'https://openalex.org/W2049150348', 'https://openalex.org/W2050569561', 'https://openalex.org/W2052307177', 'https://openalex.org/W2056840435', 'https://openalex.org/W2061405206', 'https://openalex.org/W2066578305', 'https://openalex.org/W2076883436', 'https://openalex.org/W2077977915', 'https://openalex.org/W2092656571', 'https://openalex.org/W2099464491', 'https://openalex.org/W2106167767', 'https://openalex.org/W2112661424', 'https://openalex.org/W2116328859', 'https://openalex.org/W2116788801', 'https://openalex.org/W2116997576', 'https://openalex.org/W2117319049', 'https://openalex.org/W2120140146', 'https://openalex.org/W2144263923', 'https://openalex.org/W2147533928', 'https://openalex.org/W2150539008', 'https://openalex.org/W2154704815', 'https://openalex.org/W2157714482', 'https://openalex.org/W2160754136', 'https://openalex.org/W2161251566', 'https://openalex.org/W2165262318', 'https://openalex.org/W2299448387', 'https://openalex.org/W2344651313', 'https://openalex.org/W2346338495', 'https://openalex.org/W2401190203', 'https://openalex.org/W82252971'], 'related_works': ['https://openalex.org/W2793230427', 'https://openalex.org/W2426096361', 'https://openalex.org/W2312624647', 'https://openalex.org/W2118519973', 'https://openalex.org/W2082917745', 'https://openalex.org/W2047710688', 'https://openalex.org/W2003173759', 'https://openalex.org/W1988089211', 'https://openalex.org/W122125369', 'https://openalex.org/W10914289'], 'abstract_inverted_index': {'The': [0], 'present': [1], 'study': [2], 'introduces': [3], 'metabolic': [4], 'modeling': [5, 214], 'as': [6], 'a': [7, 77, 167], 'new': [8], 'tool': [9], 'to': [10, 53, 149, 171, 217, 233, 243], 'analyze': [11], 'the': [12, 18, 85, 95, 125, 134, 151, 172, 187, 210, 218, 222], 'network': [13], 'of': [14, 29, 38, 45, 64, 80, 127, 136, 190, 196, 209, 221, 224], 'redox': [15, 101, 168, 188], 'reactions': [16], 'composing': [17], 'superoxide': [19], 'dismutase-ascorbate': [20], '(Asc)-glutathione': [21], '(GSH)': [22], 'cycle.': [23], 'Based': [24], 'on': [25, 186], 'previously': [26], 'determined': [27], 'concentrations': [28, 61], 'antioxidants': [30, 46], 'and': [31, 41, 57, 62, 66, 82, 99, 140, 145, 236], 'defense': [32], 'enzymes': [33], 'in': [34, 60, 71, 76, 130, 175, 179, 199, 251], 'chloroplasts,': [35], 'kinetic': [36], 'properties': [37], 'antioxidative': [39], 'enzymes,': [40], 'nonenzymatic': [42, 131], 'rate': [43], 'constants': [44], 'with': [47, 87], 'reactive': [48], 'oxygen,': [49], 'models': [50], 'were': [51, 147], 'constructed': [52], 'simulate': [54], 'oxidative': [55, 69], 'stress': [56, 70, 249], 'calculate': [58], 'changes': [59], 'fluxes': [63], 'oxidants': [65], 'antioxidants.': [67], 'Simulated': [68, 194], 'chloroplasts': [72], 'did': [73], 'not': [74, 165], 'result': [75], 'significant': [78, 184], 'accumulation': [79, 182], 'O2*-': [81], 'H2O2': [83, 181, 201], 'when': [84], 'supply': [86], 'reductant': [88], 'was': [89, 103, 117, 121], 'sufficient.': [90], 'Model': [91], 'results': [92], 'suggest': [93], 'that': [94, 160, 231, 240], 'coupling': [96], 'between': [97], 'Asc-': [98], 'GSH-related': [100], 'systems': [102, 226], 'weak': [104], 'because': [105], 'monodehydroascorbate': [106, 137], 'radical': [107, 138], 'reductase': [108, 115, 120, 139, 144], 'prevented': [109], 'dehydroascorbate': [110], '(DHA)': [111], 'formation': [112], 'efficiently.': [113], 'DHA': [114, 141], 'activity': [116], 'dispensable.': [118], 'Glutathione': [119], 'mainly': [122], 'required': [123], 'for': [124, 247], 'recycling': [126], 'GSH': [128, 146], 'oxidized': [129], 'reactions.': [132], 'In': [133, 212], 'absence': [135], 'reductase,': [142], 'glutathione': [143], 'capable': [148], 'maintain': [150], 'Asc': [152, 176], 'pool': [153], 'more': [154], 'than': [155], '99%': [156], 'reduced.': [157], 'This': [158], 'suggests': [159], 'measured': [161], 'DHA/Asc': [162], 'ratios': [163], 'do': [164], 'reflect': [166], 'balance': [169, 189], 'related': [170], 'Asc-GSH-cycle.': [173, 211], 'Decreases': [174], 'peroxidase': [177], 'resulted': [178, 198], 'marked': [180], 'without': [183], 'effects': [185], 'Asc/DHA': [191], 'or': [192], 'GSH/GSSG.': [193], 'loss': [195], 'SOD': [197], 'higher': [200, 248], 'production': [202], 'rates,': [203], 'thereby': [204], 'affecting': [205], 'all': [206], 'subsequent': [207], 'steps': [208], 'conclusion,': [213], 'approaches': [215], 'contribute': [216], 'theoretical': [219], 'understanding': [220], 'functioning': [223], 'antioxidant': [225], 'by': [227], 'pointing': [228], 'out': [229], 'questions': [230], 'need': [232], 'be': [234], 'validated': [235], 'provide': [237], 'additional': [238], 'information': [239], 'is': [241], 'useful': [242], 'develop': [244], 'breeding': [245], 'strategies': [246], 'resistance': [250], 'plants.': [252]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2132941431', 'counts_by_year': [{'year': 2024, 'cited_by_count': 12}, {'year': 2023, 'cited_by_count': 15}, {'year': 2022, 'cited_by_count': 15}, {'year': 2021, 'cited_by_count': 15}, {'year': 2020, 'cited_by_count': 22}, {'year': 2019, 'cited_by_count': 23}, {'year': 2018, 'cited_by_count': 14}, {'year': 2017, 'cited_by_count': 14}, {'year': 2016, 'cited_by_count': 16}, {'year': 2015, 'cited_by_count': 27}, {'year': 2014, 'cited_by_count': 17}, {'year': 2013, 'cited_by_count': 32}, {'year': 2012, 'cited_by_count': 27}], 'updated_date': '2024-12-13T09:53:57.627008', 'created_date': '2016-06-24'}