Publication Information

{'id': 'https://openalex.org/W2132495730', 'doi': 'https://doi.org/10.1074/jbc.m404651200', 'title': 'Casein Kinase 1α Interacts with Retinoid X Receptor and Interferes with Agonist-induced Apoptosis', 'display_name': 'Casein Kinase 1α Interacts with Retinoid X Receptor and Interferes with Agonist-induced Apoptosis', 'publication_year': 2004, 'publication_date': '2004-07-01', 'ids': {'openalex': 'https://openalex.org/W2132495730', 'doi': 'https://doi.org/10.1074/jbc.m404651200', 'mag': '2132495730', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/15131121'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/jbc.m404651200', 'pdf_url': 'http://www.jbc.org/article/S0021925819711089/pdf', 'source': {'id': 'https://openalex.org/S140251998', 'display_name': 'Journal of Biological Chemistry', 'issn_l': '0021-9258', 'issn': ['0021-9258', '1067-8816', '1083-351X'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'http://www.jbc.org/article/S0021925819711089/pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100647556', 'display_name': 'Yi Zhao', 'orcid': 'https://orcid.org/0000-0002-6512-5096'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yi Zhao', 'raw_affiliation_strings': ['Departments of Biology and'], 'affiliations': [{'raw_affiliation_string': 'Departments of Biology and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040911962', 'display_name': 'Suofu Qin', 'orcid': 'https://orcid.org/0000-0002-3323-8846'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Suofu Qin', 'raw_affiliation_strings': ['Retinoid Research'], 'affiliations': [{'raw_affiliation_string': 'Retinoid Research', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034552923', 'display_name': 'Larissa Atangan', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Larissa I. 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148, 218, 315, 869, 1140, 1442, 1913, 1966, 2120, 2735, 3132, 3178, 3769, 3962], 'lymphoma.': [52, 219], 'However,': [53, 220, 830, 2418], 'molecular': [55, 222, 3955], 'mechanisms': [56, 223, 853, 3956, 3981], 'that': [57, 70, 75, 144, 224, 237, 242, 311, 854, 863, 1073, 1134, 1146, 1418, 1540, 1566, 1629, 2008, 2109, 2134, 2262, 2302, 2312, 2432, 2544, 2562, 2772, 2813, 2891, 3050, 3134, 3204, 3246, 3250, 3286, 3358, 3431, 3684, 3702, 3752, 3760, 3825, 3839, 3859, 3917, 3992], 'underlie': [58, 225], 'anti-cancer': [60, 162, 227, 329, 3999], 'effects': [61, 163, 228, 330, 344, 1172, 1435, 3255], 'RXR': [63, 79, 92, 104, 113, 135, 153, 165, 230, 246, 259, 271, 280, 302, 320, 332, 466, 843, 1035, 1074, 1160, 1163, 1182, 1187, 1221, 1224, 1545, 2100, 2118, 2162, 2246, 2265, 2422, 2431, 2436, 2452, 2462, 2494, 2499, 2659, 2696, 2741, 2793, 2799, 2893, 2903, 2913, 3032, 3036, 3056, 3063, 3080, 3107, 3119, 3137, 3147, 3155, 3168, 3172, 3199, 3212, 3226, 3248, 3257, 3276, 3287, 3362, 3753, 3765, 3779, 3786, 3827, 3844, 3854, 3868, 3918, 3983, 4002], 'agonists': [64, 231, 467, 1036, 1075, 2495, 3258], 'remain': [65, 232, 3615], 'unclear.': [66, 233], 'Here,': [67, 234], 'we': [68, 235, 1154, 3130], 'show': [69, 236, 2261, 2470], 'a': [71, 110, 238, 277, 542, 1177, 1462, 1585, 1614, 1635, 1751, 1941, 2170, 2198, 2285, 2298, 2316, 2427, 2486, 2616, 2859, 3323, 3620, 3698, 3877, 3924], 'novel': [72, 239, 3434, 3980], 'pro-apoptotic': [73, 240, 1168], 'pathway': [74, 241, 1190], 'is': [76, 81, 243, 248, 888, 933, 1022, 1191, 1625, 2433, 2540, 2545, 2785, 2817, 3259, 3650, 3832, 3873, 3915, 3921, 3947], 'induced': [77, 244, 2169, 2434], 'by': [78, 84, 150, 245, 251, 317, 345, 1029, 1081, 1194, 1365, 1430, 1446, 1526, 1910, 1964, 1996, 2038, 2061, 2160, 2195, 2244, 2255, 2336, 2435, 2548, 2807, 2932, 3064, 3191, 3211, 3297, 3348, 3368, 3417, 3704, 3853, 3923, 3957], 'agonist': [80, 105, 247, 272, 1161, 1222, 1229, 2163, 2269, 2437, 2504, 2894, 3213, 3869], 'negatively': [82, 249, 1192], 'regulated': [83, 250, 1193, 3922], 'casein': [85, 252, 381, 1198], 'kinase': [86, 253, 382, 1197, 1199, 2015, 2300, 2429, 2449, 2471, 2484, 2508, 2538, 2565, 2575, 2590, 2598, 2758, 2774, 2816, 2856, 3188, 3218, 3328, 3600], '1α': [87, 254, 1200], '(CK1α).': [88, 255, 1201], 'CK1α': [89, 108, 127, 145, 158, 256, 275, 294, 312, 325, 1346, 1817, 2661, 2693, 2765, 2830, 2851, 2900, 2905, 3014, 3026, 3115, 3170, 3240, 3270, 3311, 3341, 3374, 3649, 3692, 3758, 3777, 3872, 3994], 'associates': [90, 257], 'with': [91, 112, 118, 152, 258, 279, 285, 319, 461, 860, 890, 1086, 1408, 1452, 1472, 1483, 1735, 1821, 1828, 1868, 1915, 1947, 2284, 2304, 2476, 2518, 2703, 2794, 2801, 3169, 3225, 3337, 3420, 3757, 3764, 3778, 3865], 'an': [94, 103, 261, 270, 1186, 2308, 2447, 2457, 2498, 2502, 2541, 2779, 3678], 'agonist-dependent': [95, 262, 2309], 'manner': [96, 263, 2202, 2310, 2488, 3699], 'phosphorylates': [98, 265, 2566], 'RXR.': [99, 266, 3020], 'The': [100, 267, 1130, 1360, 1434, 1479, 1623, 1811, 1950, 2552, 2574, 2603, 3953], 'ability': [101, 120, 268, 287, 458], 'recruit': [107, 274, 2899], 'complex': [111, 278, 898, 2322, 2453, 3249, 3683, 3879, 3946], 'cells': [115, 130, 282, 297, 839, 1039, 1080, 1148, 1174, 1389, 1400, 1449, 1471, 1480, 1539, 1563, 1581, 1591, 1600, 1721, 1827, 1867, 2133, 2149, 2156, 2177, 2185, 2205, 2212, 2228, 2240, 2296, 2445, 2467, 2517, 2701, 2711, 2833, 3157, 3203, 3230, 3238, 3289, 3314, 3336, 3357, 3391, 3847], 'correlates': [116, 283], 'inversely': [117, 284], 'its': [119, 286, 530, 1265, 2268, 2668, 3611], 'inhibit': [122, 289], 'growth.': [123, 290], 'Remarkably,': [124, 291], 'depletion': [125, 292], 'resistant': [129, 296, 3159], 'renders': [131, 298, 3845], 'them': [132, 299], 'susceptible': [133, 300], 'agonist-induced': [136, 154, 303, 321, 1188, 3033, 3040, 3148, 3173], 'inhibition': [138, 305, 2159, 2234, 2584, 3150, 3175, 3208, 3296, 3347, 3367, 3767], 'apoptosis.': [140, 155, 307, 322, 1152, 3774], 'Our': [141, 308], 'study': [142, 309], 'shows': [143, 310], 'can': [146, 313, 1136, 2929, 3996], 'promote': [147, 314], 'survival': [149, 316, 1141], 'interfering': [151, 318, 378], 'Inhibition': [156, 323, 2104, 3280], 'may': [159, 326, 1149, 3290], 'enhance': [160, 327, 3997], 'agonists.': [166, 333, 4003], 'Retinoids': [334, 1202], '(natural': [335], 'retinoic': [336, 356, 365], 'acids': [337], 'their': [339, 457], 'derivatives)': [341], 'exert': [342], 'biological': [343, 3125], 'regulating': [346, 868, 1139], 'gene': [347, 1647, 3415, 3441, 3790], 'transcription': [348, 2927, 3416, 3442], 'through': [349], 'two': [350, 3381, 3406], 'classes': [351], 'nuclear': [353, 453, 464, 881, 2923, 3424], 'receptors,': [354], '(RAR': [359], '1The': [360], 'abbreviations': [361], 'are:': [363], 'RAR,': [364], 'receptor;': [367, 371], 'RXR,': [368, 891, 1426], 'NGF,': [372], 'nerve': [373], 'factor;': [375], 'siRNA,': [376], 'small': [377], 'RNA;': [379], 'CK1α,': [380, 1875, 2795, 2818, 3630], '1α;': [383], 'TTNPB,': [384], '4-(E-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic': [385], 'acid;': [386], 'luc,': [387], 'luciferase.α,-β,': [388], '-γ)': [390, 399], '(RXRα,': [396], '-β,': [397], '(1Mangelsdorf': [400], 'D.J.': [401, 475, 1649, 2399], 'Thummel': [402], 'C.': [403, 485, 507, 513, 636, 707, 1099, 1101, 1103, 1278, 1280, 1282, 1831, 1837, 2344, 2367, 2935, 2969, 3088, 3568, 3570, 3572, 3717, 3723], 'Beato': [404], 'M.': [405, 417, 515, 695, 806, 816, 1835, 2634, 2937, 2959, 2973, 3721], 'Herrlich': [406], 'P.': [407, 415, 419, 435, 634, 699, 705, 1053, 2087, 2365, 2945, 2977, 3086, 3548], 'Schutz': [408], 'G.': [409, 481, 509, 650, 914, 961, 1697, 3454, 3481], 'Umesono': [410, 1650], 'K.': [411, 697, 738, 906, 912, 1651, 1799, 3446, 3452], 'Blumberg': [412], 'B.': [413, 959, 984, 1041, 1316, 1575, 3479, 3504, 3536], 'Kastner': [414], 'Mark': [416], 'Chambon': [418, 2364, 2944, 2976, 3085], 'Evans': [420, 482, 1658], 'R.M.': [421, 483, 1659], 'Cell.': [422, 486, 795, 1001, 1660, 1848, 2676, 2978, 3521, 3662, 3734, 3814, 3888], '1995;': [423, 797, 2950], '83:': [424], '835-839Abstract': [425], 'Full': [426, 490, 581, 583, 667, 1005, 1007, 1060, 1062, 1120, 1122, 1299, 1301, 1327, 1329, 1664, 1706, 1708, 1852, 1854, 2374, 2376, 2408, 2410, 2648, 2982, 2984, 3095, 3097, 3525, 3527, 3555, 3557, 3589, 3591, 3738, 3740], 'Text': [427, 491, 582, 584, 668, 1006, 1008, 1061, 1063, 1121, 1123, 1300, 1302, 1328, 1330, 1665, 1707, 1709, 1853, 1855, 2375, 2377, 2409, 2411, 2649, 2983, 2985, 3096, 3098, 3526, 3528, 3556, 3558, 3590, 3592, 3739, 3741], 'PDF': [428, 492, 585, 669, 1009, 1064, 1124, 1303, 1331, 1666, 1710, 1856, 2378, 2412, 2650, 2986, 3099, 3529, 3559, 3593, 3742], 'PubMed': [429, 441, 493, 524, 566, 586, 602, 670, 716, 732, 800, 825, 921, 978, 1010, 1065, 1125, 1304, 1332, 1667, 1711, 1806, 1857, 2095, 2355, 2379, 2413, 2651, 2681, 2953, 2987, 3001, 3100, 3461, 3498, 3530, 3560, 3594, 3667, 3743, 3819, 3893, 3910], 'Scopus': [430, 442, 494, 525, 567, 587, 603, 671, 717, 733, 801, 826, 922, 979, 1011, 1066, 1126, 1305, 1333, 1668, 1712, 1807, 1858, 2096, 2356, 2380, 2414, 2652, 2682, 2988, 3002, 3101, 3462, 3499, 3531, 3561, 3595, 3668, 3744, 3820, 3894], '(6083)': [431], 'Google': [432, 444, 496, 527, 569, 589, 605, 673, 692, 719, 735, 776, 803, 828, 924, 981, 1013, 1068, 1128, 1307, 1335, 1670, 1714, 1809, 1860, 1984, 2098, 2358, 2382, 2416, 2654, 2684, 2954, 2966, 2990, 3004, 3103, 3464, 3501, 3533, 3563, 3597, 3670, 3746, 3822, 3896, 3911], 'Scholar,': [433, 497, 570, 590, 606, 674, 693, 720, 736, 777, 804, 982, 2359, 2383, 2955, 2967, 2991, 3465, 3502, 3534, 3564, 3897], '2Chambon': [434], 'FASEB': [436], 'J.': [437, 511, 710, 726, 744, 746, 951, 963, 1054, 1105, 1114, 1284, 1293, 1321, 1700, 1793, 2349, 2368, 2402, 3089, 3471, 3483, 3549, 3574, 3583, 3904], '1996;': [438, 689, 1703], '10:': [439, 2679, 3665, 3891], '940-954Crossref': [440], '(2604)': [443], 'Scholar).': [445, 829, 925, 1014, 1069, 1129, 1715, 1810, 1861, 1985, 2099, 2417, 2685, 3005, 3104, 3598, 3747, 3912], 'RXRs': [446, 858, 1135, 2327, 3408, 3432], 'unique': [448], 'among': [449], 'members': [450], 'receptor': [454, 882, 1424], 'superfamily': [455], 'heterodimerize': [460], 'several': [462, 2492, 2588], 'other': [463, 2493, 2840, 2926, 3154, 3422], 'receptors.': [465, 3425], '(the': [468], '(3Heyman': [472], 'R.A.': [473, 614, 686, 789, 791, 1113, 1292, 1699, 2675, 3582, 3661, 3887, 3903], 'Mangelsdorf': [474, 2398], 'Dyck': [476], 'J.A.': [477, 648, 969, 3489], 'Stein': [478], 'R.B.': [479], 'Eichele': [480], 'Thaller': [484], '1992;': [487, 521], '68:': [488], '397-406Abstract': [489], '(1567)': [495], '4Levin': [498], 'A.A.': [499], 'Sturzenbecker': [500], 'L.J.': [501], 'Kazmer': [502], 'S.': [503, 1693, 2361, 2632, 2971, 3082], 'Bosakowski': [504], 'T.': [505, 1801, 2089, 3797], 'Huselton': [506], 'Allenby': [508], 'Speck': [510], 'Kratzeisen': [512], 'Rosenberger': [514], 'Lovey': [516], 'A.': [517, 632, 814, 1109, 1288, 1797, 2939, 2957, 3578], 'Grippo': [518], 'J.F.': [519], 'Nature.': [520, 1802], '355:': [522], '359-361Crossref': [523], '(1100)': [526], 'Scholar)': [528, 1308, 1336, 1671, 2655, 3823], 'analogs)': [532], 'variety': [543, 1131], 'malignant': [545, 838], 'cells,': [546, 1414, 2748, 3830], 'such': [547], 'as': [548, 1461, 1603, 1787, 1974, 2080, 2557, 2583, 3677], 'lung': [549], 'breast': [551], 'carcinomas,': [552], 'lymphomas,': [553], 'leukemias': [555], '(5Altucci': [556], 'L.': [557, 572, 779, 785, 810, 2363, 3084], 'Gronemeyer': [558, 573], 'H.': [559, 574, 608, 947, 3467], 'Nat.': [560, 915, 3455], 'Rev.': [561, 596], 'Cancer.': [562, 663], '2001;': [563, 578, 713, 1803], '1:': [564, 730], '181-193Crossref': [565], '(685)': [568], '6Altucci': [571], 'Trends': [575, 2642], 'Endocrinol.': [576, 2949], 'Metab.': [577], '12:': [579, 2999], '460-468Abstract': [580], '(107)': [588], '7Sun': [591], 'S.Y.': [592], 'Lotan': [593], 'R.': [594, 620, 656, 756, 1977, 2348], 'Crit.': [595], 'Oncol.': [597, 712], 'Hematol.': [598], '2002;': [599, 773, 1849, 1981, 3735], '41:': [600], '41-55Crossref': [601], '(295)': [604], '8DeGrendele': [607], 'Khuri': [609], 'F.R.': [610], 'Rigas': [611], 'J.R.': [612, 2395], 'Figlin': [613], 'Gralla': [615], 'R.J.': [616], 'Shin': [617], 'D.M.': [618], 'Munden': [619], 'Fox': [621], 'N.': [622, 1107, 1286, 3576], 'Huyghe': [623], 'M.R.': [624], 'Kean': [625], 'Y.': [626, 740, 904, 1111, 1290, 1833, 1841, 3444, 3580, 3719, 3727], 'Reich': [627], 'S.D.': [628, 2673, 3659, 3885, 3899], 'Hong': [629, 2392], 'W.K.': [630, 2393], 'Lansiaux': [631], 'Formstecher': [633], 'Bailly': [635], 'Bengtson': [637], 'E.M.': [638], 'Rizvi': [639], 'N.A.': [640], 'Marshall': [641], 'J.L.': [642, 760, 1049, 2391, 3544], 'Dahut': [643], 'W.': [644, 787, 990, 1795, 3510], 'Ness': [645], 'E.': [646, 818], 'Truglia': [647], 'Loewen': [649], 'Gill': [651], 'G.M.': [652], 'Ulm': [653], 'E.H.': [654], 'Geiser': [655], 'Jaunakais': [657], 'D.': [658, 701, 766], 'Hawkins': [659], 'M.J.': [660, 2389], 'Clin.': [661, 711, 727, 2350], 'Lung': [662], '2003;': [664, 1117, 1296, 3586], '4:': [665], '210-212Abstract': [666], '(5)': [672], '9Gottardis': [675], 'M.M.': [676, 768], 'Bischoff': [677], 'E.D.': [678], 'Shirley': [679, 769], 'M.A.': [680, 682, 770], 'Wagoner': [681], 'Lamph': [683, 753, 786], 'W.W.': [684, 754], 'Heyman': [685, 788], 'Cancer': [687, 771], 'Res.': [688, 772], '56:': [690], '5566-5570PubMed': [691], '10Duvic': [694], 'Hymes': [696], 'Heald': [698], 'Breneman': [700], 'Martin': [702], 'A.G.': [703], 'Myskowski': [704], 'Crowley': [706], 'Yocum': [708], 'R.C.': [709], '19:': [714], '2456-2471Crossref': [715], '(581)': [718], '11Lowe': [721], 'M.N.': [722], 'Plosker': [723], 'G.L.': [724, 783], 'Am.': [725], 'Dermatol.': [728], '2000;': [729, 822, 918, 975, 1057, 1324, 2405, 3458, 3495, 3552], '245-252Crossref': [731], '(53)': [734], '12Wu': [737], 'Zhang': [739, 972, 999, 1842, 3492, 3519, 3728], 'Xu': [741], 'X.C.': [742], 'Hill': [743], 'Celestino': [745], 'Kim': [747], 'H.T.': [748], 'Mohsin': [749], 'S.K.': [750, 949, 986, 3469, 3506], 'Hilsenbeck': [751], 'S.G.': [752], 'Bissonette': [755], 'Brown': [757], 'P.H.': [758], 'Rodriquez': [759], 'Kuhn': [761], 'J.G.': [762], 'Green': [763], 'J.E.': [764], 'Munoz-Medellin': [765], 'Gottardis': [767], '62:': [774], '6376-6380PubMed': [775], '13Nagy': [778], 'Thomazy': [780], 'V.A.': [781], 'Shipley': [782], 'Fesus': [784], 'Chandraratna': [790, 1112, 1291, 1319, 1698, 3581], 'Davies': [792, 1690], 'P.J.': [793, 1691], 'Mol.': [794, 2948, 3813], 'Biol.': [796, 917, 1055, 1115, 1294, 1322, 1701, 2369, 2403, 3090, 3457, 3550, 3584, 3815], '15:': [798], '3540-3551Crossref': [799], '(240)': [802], '14Gianni': [805], 'Ponzanelli': [807], 'I.': [808, 2943], 'Mologni': [809], 'Reichert': [811], 'U.': [812, 1655, 3809], 'Rambaldi': [813], 'Terao': [815], 'Garattini': [817], 'Cell': [819, 916, 1374, 1929, 3278, 3456, 3905], 'Death': [820], 'Differ.': [821], '7:': [823], '447-460Crossref': [824], '(93)': [827, 2653], 'despite': [831], 'ubiquitous': [833], 'expression': [834, 1371, 1473, 1616, 1873, 2828, 2863, 3011, 3024, 3300, 3309, 3842], 'RXRs,': [836], 'many': [837, 2657, 3421], 'insensitive': [841, 3206, 3364], 'agonists,': [844], 'it': [846, 3914], 'is,': [847], 'therefore,': [848], 'important': [849, 865], 'identify': [851, 1176], 'cellular': [852], 'mediate': [855], 'this': [856, 2250, 3320, 3761], 'resistance.': [857], 'associate': [859], 'various': [861, 1453, 2334], 'proteins': [862, 1952, 2058, 2841], 'play': [864, 1137, 3409], 'roles': [866, 1133, 3054, 3411], 'survival.': [870], 'Nerve': [871], 'factor': [873], '(NGF)': [874], 'induces': [875], 'phosphorylation': [877, 2420, 2933, 3687], 'orphan': [880], 'NGFI-B': [883, 932], '(Nur77': [884], 'or': [885, 1034, 1254, 1552, 1571, 1927, 1931, 2525, 2585, 2915, 3022, 3038], 'TR3),': [886], 'heterodimerized': [889], 'leading': [892], 'translocation': [894], 'NGFI-B·RXR': [897], 'out': [899, 1786], 'nucleus': [902, 937], '(15Katagiri': [903, 3443], 'Takeda': [905, 3445], 'Yu': [907, 3447], 'Z.X.': [908, 3448], 'Ferrans': [909, 3449], 'V.J.': [910, 3450], 'Ozato': [911, 3451], 'Guroff': [913, 3453], '2:': [919, 3459], '435-440Crossref': [920, 3460], '(163)': [923, 3463], 'In': [926, 3139, 3383, 3628], 'presence': [928, 2691, 2763, 3263], 'apoptotic': [930, 1189], 'stimuli,': [931], 'translocated': [934], 'from': [935, 1236, 1242, 1252, 1358, 1391, 1561, 1640, 1755, 2464, 2618, 2698, 2709, 3201], 'mitochondria,': [939], 'causing': [940], 'cytochrome': [941], 'c': [942], 'release': [943], '(16Li': [946], 'Kolluri': [948, 985, 3468, 3505], 'Gu': [950, 3470], 'Dawson': [952, 995, 3472, 3515], 'M.I.': [953, 996, 3473, 3516], 'Cao': [954, 993, 3474, 3513], 'X.': [955, 973, 994, 1845, 1847, 3475, 3493, 3514, 3731, 3733], 'Hobbs': [956, 3476], 'P.D.': [957, 3477], 'Lin': [958, 964, 987, 1844, 3478, 3484, 3507, 3730], 'Chen': [960, 3480], 'Lu': [962, 3482], 'F.': [965, 988, 3485, 3508], 'Xie': [966, 3486], 'Z.': [967, 1843, 3487, 3729], 'Fontana': [968, 3488], 'Reed': [970, 997, 3490, 3517], 'J.C.': [971, 998, 3491, 3518, 3901], 'Science.': [974, 3494], '289:': [976, 3496], '1159-1164Crossref': [977, 3497], '(589)': [980, 3500], '17Lin': [983, 3503], 'Liu': [989, 3509], 'Han': [991, 1836, 3511, 3722], 'Y.H.': [992, 3512], 'X.K.': [1000, 3520], '2004;': [1002, 3522, 3816], '116:': [1003, 3523], '527-540Abstract': [1004, 3524], '(565)': [1012, 3532], 'RXRα': [1015, 1085, 2138, 2282, 2314, 2567, 2608, 2876, 3831, 3863], 'binds': [1016], 'insulin-like': [1017, 1030], 'factor-binding': [1019, 1032], 'protein-3': [1020, 1033], 'necessary': [1023], 'induction': [1026, 3400, 3772, 3850], '(18Liu': [1040], 'Lee': [1042, 3537], 'H.Y.': [1043, 2385, 3538], 'Weinzimer': [1044, 3539], 'S.A.': [1045, 1318, 1653, 3540], 'Powell': [1046, 3541], 'D.R.': [1047, 3542], 'Clifford': [1048, 2390, 3543], 'Kurie': [1050, 2400, 3545], 'J.M.': [1051, 2401, 2975, 3546], 'Cohen': [1052, 3547], 'Chem.': [1056, 1116, 1295, 1323, 1702, 2370, 2404, 3091, 3551, 3585], '275:': [1058, 1325, 2406, 3553], '33607-33613Abstract': [1059, 3554], '(286)': [1067, 3562], 'We': [1070, 3006, 3162, 3748], 'have': [1071, 1337, 2438, 3427, 3433, 3636, 3646, 3749], 'shown': [1072, 3195, 3751], 'affect': [1076, 3075, 3782], 'proliferation': [1078], 'promoting': [1082], 'interaction': [1083, 2425, 2791, 3181, 3762, 3960], 'β-catenin': [1087, 3686, 3694], 'degradation': [1090], 'both': [1092, 1159, 2224, 2241, 2263, 2786], 'these': [1094, 2176, 3142, 3177, 3237, 3388, 3846], 'molecules': [1095], '(19Xiao': [1096, 1275], 'J.H.': [1097, 1276, 2346, 3566], 'Ghosn': [1098, 1277, 3567], 'Hinchman': [1100, 1279, 3569], 'Forbes': [1102, 1281, 3571], 'Wang': [1104, 1283, 1313, 3573], 'Snider': [1106, 1285, 3575], 'Cordrey': [1108, 1287, 3577], 'Zhao': [1110, 1289, 3579], '278:': [1118, 1297, 3587], '29954-29962Abstract': [1119, 1298, 3588], '(136)': [1127, 1306, 3596], 'leads': [1142], 'possibility': [1145, 3285], 'tumor': [1147, 3710], 'circumvent': [1150], 'RXR-driven': [1151, 2542], 'Here': [1153], 'demonstrate': [1155], 'requirement': [1157], 'protein': [1164, 1196, 1921, 2139, 2266, 2299, 2318, 2428, 2589, 3607, 3626, 3695, 3712], 'driving': [1166], 'inhibitory': [1171, 3254], 'protective': [1178], 'mechanism': [1179, 2114], 'action': [1183, 2116, 3984], 'Other': [1204], 'Materials—The': [1205], 'following': [1206], 'retinoids': [1208], 'were': [1209, 1217, 1251, 1347, 1363, 1390, 1401, 1427, 1444, 1481, 1524, 1557, 1582, 1601, 1722, 1773, 1784, 1824, 1883, 1891, 1905, 1933, 1953, 1994, 2009, 2036, 2050, 2144, 2150, 2193, 2242, 2720, 2730, 2744, 2753, 2805, 3158, 3205, 3342, 3376], 'synthesized': [1210], 'at': [1211, 1528, 1584, 1907, 2029], 'Allergan': [1212], 'Inc.': [1213], '(Irvine,': [1214], 'CA)': [1215], 'dissolved': [1218], 'Me2SO:': [1220], '(AGN194204),': [1223], 'antagonist': [1225, 2247, 2500], '(AGN195393),': [1226], 'RAR': [1228, 2503, 3039], '(TTNPB).': [1230], 'Monoclonal': [1231, 1238], 'anti-FLAG': [1232], '(M2)': [1233], 'antibody': [1234, 1240], 'was': [1235, 1241, 1475, 1547, 1760, 1968, 2059, 2066, 2662, 2820, 3182, 3222, 3304, 3602], 'Sigma.': [1237], 'anti-V5': [1239], 'Invitrogen.': [1243, 1359], 'Polyclonal': [1244], 'anti-RXRα': [1245], '(D20),': [1246], 'anti-CK1α,': [1247], 'CK1ϵ': [1249, 1819, 2838, 2865], 'antibodies': [1250, 1917], 'Stressgen': [1253], 'Santa': [1255], 'Cruz': [1256], 'Biotechnology.': [1257], 'Construction': [1258], 'Expression': [1260], 'Vectors—Constructions': [1261], 'FLAG-RXR': [1263], 'mutants': [1266, 2743, 2800], '(RXR-CDE,': [1267], 'RXR-DE,': [1268], 'RXR-E,': [1269], 'RXR-ΔC,': [1270], 'RXR-ΔAF2,': [1271], 'RXR-CDEΔAF2,': [1272], 'RXR-DEΔAF2,': [1273], 'RXR-EΔAF2)': [1274], 'pRARα-V5': [1310], '(20Klein': [1311], 'E.S.': [1312, 1657, 1685], 'J.W.': [1314], 'Khalifa': [1315], 'Gavigan': [1317], 'R.A.S.': [1320], '19401-19408Abstract': [1326], '(34)': [1334], 'been': [1338, 2340, 2440, 3071, 3429, 3637, 3675], 'described': [1339, 1604, 1788, 1813, 1975, 2081, 2341], 'previously.': [1340], 'Full-length': [1341], 'human': [1342, 1422, 2129, 2607], 'cDNA': [1343], 'clones': [1344], 'found': [1348, 3875], 'expressed': [1351, 3239], 'sequence': [1352, 1638], 'tag': [1353], 'data': [1354, 2260, 2889, 3048], 'base': [1355], 'purchased': [1357], 'coding': [1361], 'regions': [1362], 'amplified': [1364], 'PCR': [1366], 'inserted': [1368, 1672, 1884], 'into': [1369, 1549, 1826, 1885, 2057, 2746, 3123, 3931, 3978], 'vector': [1372, 1617], 'pcDNA3.1.': [1373], 'Culture,': [1375], 'Recombinant': [1376], 'Protein': [1377, 1986, 2286, 2619], 'Expression,': [1378], 'Transactivation': [1380], 'Assay—Human': [1381], 'embryonic': [1382], 'kidney': [1383], '(HEK293),': [1384], 'HeLa,': [1385], 'CV-1,': [1386], 'Jurkat': [1388, 1866, 2132, 2142, 2280, 3356, 3390], 'ATCC': [1392, 1397], 'grown': [1394], 'according': [1395, 1893], 'instructions.': [1398], 'DT40': [1399, 2127, 2211, 2227, 2278], 'maintained': [1402], 'RPMI': [1404], '1640': [1405], 'medium': [1406, 1565, 1729], 'supplemented': [1407], '10%': [1409, 1494], 'fetal': [1410], 'bovine': [1411], 'serum.': [1412], 'HircRXR': [1413], 'rat': [1416], 'fibroblasts': [1417], 'stably': [1419, 1541, 2135], 'express': [1420, 1542], 'insulin': [1423], 'kindly': [1428], 'provided': [1429], 'Dr.': [1431], 'Jyoti': [1432], 'Kusari.': [1433], 'AGN194204': [1437, 2164, 2168, 2196, 2477, 2481, 2529, 2704, 2884, 3349, 3369, 3385], 'on': [1438, 1937, 1970, 2068, 2119, 2569, 2595, 3030], 'lines': [1443, 1890, 3133], 'measured': [1445, 3183], 'counting': [1447], 'viable': [1448], 'after': [1450, 1718], 'doses': [1454], '3–6': [1456], 'days.': [1457], 'Data': [1458], 'presented': [1460], 'percentage': [1463], 'control': [1465], '(without': [1466], 'treatment).': [1467], 'Transfection': [1468], 'vectors': [1474], 'performed': [1476, 1906, 1969, 2067], 'using': [1477, 1750, 1955, 2073, 2294, 2615, 3184], 'LipofectAMINE.': [1478], 'lysed': [1482], 'lysis': [1484], 'buffer': [1485, 2017], '(30': [1486, 2018], 'mm': [1487, 1497, 1500, 1504, 1507, 1512, 2019, 2025], 'Tris-HCl,': [1488, 2020], 'pH': [1489, 2021], '7.4,': [1490, 2022], '1%': [1491], 'Nonidet': [1492], 'P-40,': [1493], 'glycerol,': [1495], '150': [1496], 'NaCl,': [1498], '1': [1499, 1506, 3601], 'EDTA)': [1501], 'plus': [1502], '40': [1503], 'NaF,': [1505], 'sodium': [1508], 'orthovanadate,': [1509], '0.5': [1511], 'phenylmethylsulfonyl': [1513], 'fluoride,': [1514], '1×': [1516], 'protease': [1517], 'inhibitors': [1518], '(Roche': [1519], 'Applied': [1520], 'Science),': [1521], 'lysates': [1523, 2699, 2736], 'clarified': [1525, 1912], 'centrifugation': [1527], '12,000': [1529], '×': [1530, 1589], 'g.': [1531], 'To': [1532, 1862, 2811], 'establish': [1533], 'HEK293,': [1534], 'DT40,': [1535], 'Jurkat,': [1536], 'HeLa': [1538], 'RXRα,': [1543], 'insert': [1546], 'subcloned': [1548], 'pcDNA3.1': [1550, 1553], '(neomycin)': [1551], '(hygromycin).': [1554], 'Individual': [1555], 'colonies': [1556], 'selected': [1558], 'expanded': [1560], 'transfected': [1562, 1602, 1825, 2745], 'contained': [1567, 1613, 2776], '0.6–2': [1568], 'mg/ml': [1569, 1573], 'Geneticin': [1570], '0.3': [1572], 'hygromycin': [1574], 'For': [1576], 'transactivation': [1578, 3034, 3041], 'assay,': [1579], 'CV-1': [1580], 'seeded': [1583], 'concentration': [1586], '1.5': [1588], '105': [1590], 'per': [1592], 'well': [1593], '6-well': [1595], 'plates.': [1596], 'After': [1597], 'overnight': [1598], 'culture,': [1599], 'legend': [1607], 'Fig.': [1609, 3197], '4.': [1610], 'All': [1611, 2768], 'transfections': [1612], 'β-galactosidase': [1615, 1745, 1764], '(Promega)': [1618], 'correct': [1620], 'transfection': [1621, 1769], 'efficiency.': [1622, 1770], 'pRXRE-Luc': [1624], 'report': [1627], 'plasmid': [1628, 1822], 'contains': [1630, 1679, 2609], 'five': [1631], 'tandem': [1632], 'repeats': [1633], '35-base': [1636], 'pair': [1637], '(DR-1)': [1639], 'promoter': [1642], 'mouse': [1645], 'CRBP-II': [1646], '(21Mangelsdorf': [1648], 'Kliewer': [1652], 'Borgmeyer': [1654], 'Ong': [1656], '1991;': [1661, 2092], '66:': [1662], '555-561Abstract': [1663], '(525)': [1669], 'immediately': [1673], 'upstream': [1674], 'thymidine': [1676], 'kinase-luciferase.': [1677], 'pRARE-Luc': [1678], 'three': [1680], 'copies': [1681], 'DR-5': [1683], '(22Klein': [1684], 'Pino': [1686], 'M.E.': [1687], 'Johnson': [1688], 'A.T.': [1689], 'Nagpal': [1692], 'Thacher': [1694], 'S.M.': [1695, 1791], 'Krasinski': [1696], '271:': [1704], '22692-22696Abstract': [1705], '(98)': [1713], '24': [1716], 'h': [1717, 1727, 1926], 'transfection,': [1719], 'incubated': [1723], 'another': [1725], '16': [1726], 'containing': [1730], '0.5%': [1731], 'charcoal-treated': [1732], 'serum': [1733], 'along': [1734], 'ligand': [1737], 'then': [1739, 3343], 'harvested': [1740], 'measurement': [1743], 'activity': [1746, 1749, 1759, 1765, 2301, 2472, 2509, 2539, 2599, 2671, 2759, 2775, 2919, 3018, 3221, 3329, 3784], 'luciferase': [1748, 1758], 'system': [1752, 2079], 'protocol': [1754], 'Promega.': [1756], 'Relative': [1757], 'normalized': [1761], 'account': [1767], 'Triplicate': [1771], 'wells': [1772], 'each': [1776, 3642], 'experimental': [1777], 'group.': [1778], 'Small': [1779], 'Interfering': [1780], 'RNA': [1781], '(siRNA)—siRNA': [1782], 'experiments': [1783], 'carried': [1785], 'previously': [1789, 1812], '(23Elbashir': [1790], 'Harborth': [1792], 'Lendeckel': [1794], 'Yalcin': [1796], 'Weber': [1798], 'Tuschl': [1800], '411:': [1804], '494-498Crossref': [1805], '(8157)': [1808], 'siRNA': [1814, 2819, 3303], 'oligonucleotides': [1815, 1882], 'together': [1820], 'DNAs': [1823], 'LipofectAMINE': [1829], '(24Liu': [1830, 3716], 'Li': [1832, 3718], 'Semenov': [1834, 3720], 'Baeg': [1838, 3724], 'G.H.': [1839, 3725], 'Tan': [1840, 3726], 'He': [1846, 3732], '108:': [1850, 3736], '837-847Abstract': [1851, 3737], '(1663)': [1859, 3745], 'generate': [1863], 'HEK293RXR': [1864, 3313], 'stable': [1869], 'suppression': [1870], 'same': [1877, 2321], 'sequences': [1878], 'double-strand': [1880], 'DNA': [1881, 1961], 'pSiren-RetroQ': [1886], '(BD': [1887, 1972], 'Biosciences),': [1888], 'created': [1892], "manufacturer's": [1896], 'protocols.': [1897], 'Immunoprecipitation,': [1898], 'Immunoblot': [1899], 'Analysis,': [1900], 'Flow': [1902], 'Cytometric': [1903], 'Analysis—Immunoprecipitations': [1904], '4': [1908, 1925], '°C': [1909, 2031], 'incubating': [1911], 'extracts': [1914, 1930], '(2–5': [1918], 'μg/ml)': [1919], 'A/G-agarose': [1922], 'beads': [1923], 'overnight.': [1928], 'immunoprecipitates': [1932, 2697, 2708, 2752, 2771, 3200], 'subjected': [1934], 'separation': [1936], 'SDS-PAGE,': [1938], 'transferred': [1939], 'polyvinylidene': [1942], 'difluoride': [1943], 'membrane,': [1944], 'immunoblotted': [1946], 'specific': [1948], 'antibodies.': [1949], 'targeted': [1951], 'detected': [1954, 2722], 'enhanced': [1956, 3144], 'chemiluminescence': [1957], 'immunodetection': [1958], '(Amersham': [1959], 'Biosciences).': [1960], 'content': [1962], 'analysis': [1963, 2065, 2560, 2614, 2688], 'fluorescence-activated': [1965], 'sorter': [1967], 'FACScan™': [1971], 'Biosciences)': [1973], '(25Wang': [1976], 'Shi': [1978], 'Y.F.': [1979], 'BioTechniques.': [1980], '33:': [1982], 'S88-S91Crossref': [1983], 'Kinase': [1987, 2287, 2554, 2620, 3116, 3220], 'Assay': [1988], 'Phosphoamino': [1990, 2063], 'Acid': [1991], 'Analysis—Kinase': [1992], 'reactions': [1993, 2035], 'initiated': [1995], 'adding': [1997, 2039], '2': [1998], 'μlof50': [1999], 'μm': [2000], '[γ-32P]ATP': [2001], '(10': [2002], 'μCi)': [2003], 'immunoprecipitated': [2006, 3224], 'complexes': [2007], 'suspended': [2010], '15': [2012], 'μl': [2013, 2041], 'assay': [2016, 3189], '10': [2024], 'MgCl2).': [2026], 'Following': [2027], 'incubation': [2028], '30': [2030], '20': [2033], 'min,': [2034], 'terminated': [2037], '6': [2040], '4×': [2043], 'SDS': [2044], 'sample': [2045], 'loading': [2046], 'buffer,': [2047], 'mixtures': [2049], 'resolved': [2051], 'onto': [2052], 'SDS-PAGE.': [2053], 'Incorporation': [2054], '32P': [2056], 'determined': [2060], 'autoradiography.': [2062], 'thin': [2069, 2076], 'layer': [2070, 2077], 'cellulose': [2071], 'plates': [2072], 'Hunter': [2075, 2088], 'electrophoresis': [2078], '(26Boyle': [2082], 'W.J.': [2083], 'van': [2084], 'der': [2085], 'Geer': [2086], 'Methods': [2090], 'Enzymol.': [2091], '201:': [2093], '110-149Crossref': [2094], '(1276)': [2097], 'Agonist': [2101, 2442], 'Induces': [2102], 'Growth': [2103, 3109, 3279], 'Apoptosis': [2106], 'Cells': [2108, 3272], 'Overexpress': [2110], 'RXRα—To': [2111], 'examine': [2112], 'apoptosis,': [2123, 3152], 'chicken': [2124], 'B': [2125], 'lymphoma': [2126, 2131], 'overexpress': [2136, 3361], '(DT40RXR': [2140], 'RXR)': [2143], 'generated': [2145], '(Fig.': [2146, 2165, 2178, 2206, 2257, 2323, 2489, 2531, 2572, 2712, 2766, 2845, 2869, 3045, 3160, 3241, 3315, 3330, 3350, 3378, 3403], '1a).': [2147], 'These': [2148, 2259, 2888, 3047, 3243, 3856], 'dramatically': [2151, 2852], 'more': [2152], 'sensitive': [2153, 3293, 3344, 3372, 3848], 'than': [2154, 2455], 'parental': [2155, 2184], '1b),': [2166], 'significant': [2171, 3988], 'level': [2172, 2826, 2849], '1c)': [2179], 'but': [2180, 2705], 'not': [2181, 2187, 2209, 2214, 2230, 2469, 2479, 2511, 2521, 2546, 2601, 2706, 2721, 2738, 2886, 3074, 3223, 3360, 3781], '(data': [2186, 2213, 2229, 2478, 2510, 2600, 2737, 2885], 'shown).': [2188, 2215, 2231, 2480, 2512, 2602, 2739, 2887], 'Similarly,': [2189, 3354], 'caspase-3': [2190, 2220], '-9': [2192, 2222], 'activated': [2194, 2219, 2448, 3065], 'dose-': [2199], 'time-dependent': [2201], 'DT40RXR': [2204, 2225, 2239], '1d)': [2207], 'By': [2216, 2714], 'contrast,': [2217, 2715], 'H2O2': [2218], 'Agonist-induced': [2232, 3108, 3277], 'caspase': [2236], 'activation': [2237, 2332, 3395], 'blocked': [2243], 'AGN195393,': [2248], 'agent': [2251], 'had': [2252, 2592, 2773, 2866, 3027, 3135, 3143, 3217], 'no': [2253, 2593, 2867, 3028], 'effect': [2254, 2594, 2868, 3029], 'itself': [2256], '1e).': [2258], 'required': [2271], 'Associates': [2283], 'Presence': [2290, 3113], 'RXR-specific': [2292], 'Ligands—Studies': [2293], 'HEK293': [2295, 2466, 2516, 2747, 2832], 'revealed': [2297], 'co-immunoprecipitated': [2303, 2564], 'overexpressed': [2305], 'FLAG-RXRα': [2306], 'phosphorylated': [2313, 2806, 2875, 3929, 3944], '160-kDa': [2317], '2a).': [2324], 'Phosphorylation': [2325, 3061], 'response': [2329, 2530, 2543], 'pathways': [2335], 'extracellular': [2337], 'stimuli': [2338], 'has': [2339, 3069, 3673], 'before': [2342], '(27Solomon': [2343], 'White': [2345], 'Kremer': [2347], 'Investig.': [2351], '1999;': [2352, 2371, 3092, 3907], '103:': [2353], '1729-1735Crossref': [2354], '(124)': [2357], '28Adam-Stitah': [2360], 'Penna': [2362, 3083], 'Rochette-Egly': [2366, 3087], '274:': [2372, 3093], '18932-18941Abstract': [2373, 3094], '(73)': [2381, 3102], '29Lee': [2384], 'Suh': [2386], 'Y.A.': [2387], 'Robinson': [2388], 'Woodgett': [2394], 'Cobb': [2396], 'M.H.': [2397], '32193-32199Abstract': [2407], '(85)': [2415], 'between': [2426], 'never': [2439], 'reported.': [2441], 'recruited': [2446, 2482, 2506], 'rather': [2454], 'activating': [2456], 'already': [2458], 'associated': [2459, 2809], 'kinase,': [2460], 'because': [2461, 2666], 'immunocomplexes': [2463], 'untreated': [2465, 2710], 'did': [2468, 2520], 'when': [2473, 3373], 'treated': [2474, 2702], 'subsequently': [2475], 'dose-dependent': [2487], '2b).': [2490], 'Furthermore,': [2491], '(but': [2496], 'neither': [2497], 'nor': [2501], '(TTNPB))': [2505], 'Also,': [2513, 2871], 'cotransfection': [2514], 'RARα': [2519], 'alter': [2522], 'specificity': [2524], 'efficacy': [2526], '2c).': [2532], 'Thus,': [2533], 'agonist-mediated': [2535, 3919], 'recruitment': [2536], 'mediated': [2547], 'classical': [2549], 'RXR·RAR': [2550, 2916, 3043], 'heterodimers.': [2551], 'RXR-associated': [2553, 2597, 2815, 2855, 3327], 'Is': [2555, 2906], 'Identified': [2556], 'CK1α—Phosphoamino': [2558], 'demonstrated': [2561, 2689], 'primarily': [2568], 'Ser': [2570, 2611], 'residues': [2571], '3a).': [2573], 'interest': [2577, 2665], 'appears': [2578, 3644, 3653], 'be': [2580, 2930, 3291, 3655, 3937], 'constitutively': [2581, 3656], 'active': [2582, 3657], 'stimulation': [2586], 'cascades': [2591], 'A/B': [2604, 2803], 'domain': [2605], '26': [2610], 'residues,': [2612], 'program': [2617], 'Resources': [2621], '(University': [2622], 'California,': [2624], 'San': [2625], 'Diego)': [2626], '(30Smith': [2627], 'C.M.': [2628], 'Shindyalov': [2629], 'I.N.': [2630], 'Veretnik': [2631], 'Gribskov': [2633], 'Taylor': [2635, 3804], 'S.S.': [2636], 'Ten': [2637], 'Eyck': [2638], 'L.F.': [2639], 'Bourne': [2640], 'P.E.': [2641], 'Biochem.': [2643], 'Sci.': [2644, 3906], '1997;': [2645, 2963, 2979], '22:': [2646], '444-446Abstract': [2647], 'yielded': [2656], 'potential': [2658], 'kinases.': [2660, 3627], 'particular': [2664], 'known': [2669], 'constitutive': [2670], '(31Gross': [2672, 3658, 3884], 'Anderson': [2674, 3660, 3886, 3902], 'Signal.': [2677, 3663, 3889], '1998;': [2678, 2998, 3664, 3890], '699-711Crossref': [2680, 3666, 3892], '(269)': [2683, 3669, 3895], 'Indeed,': [2686], 'immunoblot': [2687, 3192], '3b).': [2713], 'CK1ϵ,': [2716], 'CK1δ,': [2717], 'CK2': [2719], 'any': [2724], 'immunoprecipitates,': [2727], 'although': [2728], 'clearly': [2731, 3750], 'present': [2732], 'Several': [2740], 'deletion': [2742], 'corresponding': [2751], 'examined': [2754, 3131], 'vitro': [2757, 2878, 3187], '3c).': [2767], 'CK1α.': [2777, 2810, 3060, 3265, 3302], 'Moreover,': [2778], 'intact': [2780, 2802], 'ligand-binding': [2781], 'region': [2782], '(E': [2783], 'domain)': [2784], 'essential': [2787, 3679], 'sufficient': [2789], 'only': [2797], 'those': [2798], 'domains': [2804], 'confirm': [2812], 'significantly': [2823], 'reduce': [2824, 3307], 'without': [2834], 'affecting': [2835], 'levels': [2836, 3012, 3339, 3375], '(RXRα': [2842], 'β-actin)': [2844], '3d).': [2846, 2870], 'Reducing': [2847, 3266], 'reduced': [2853], 'activity,': [2857], 'whereas': [2858, 3153], 'reduction': [2860, 3325], 'recombinant': [2872], 'CK1': [2873, 3618], 'effectively': [2874], 'even': [2879, 3235], 'absence': [2882], 'indicate': [2890, 3049], 'functions': [2895, 3078, 3436], 'vivo': [2897, 3756], 'complex.': [2904], 'Not': [2907], 'Required': [2908], 'Transcriptional': [2910], 'Activities': [2911], 'Homodimers': [2914], 'Heterodimers—The': [2917], 'transcriptional': [2918, 3017, 3053, 3077], 'certain': [2921], 'hormone': [2922], 'factors': [2928], 'modulated': [2931], '(32Rochette-Egly': [2934], 'Oulad-Abdelghani': [2936], 'Staub': [2938], 'Pfister': [2940], 'V.': [2941], 'Scheuer': [2942], 'Gaub': [2946], 'M.P.': [2947], '9:': [2951], '860-871Crossref': [2952], '33Minden': [2956], 'Karin': [2958], 'Biochim.': [2960], 'Biophys.': [2961], 'Acta.': [2962], '1333:': [2964], 'F85-F104PubMed': [2965], '34Rochette-Egly': [2968], 'Adam': [2970], 'Rossignol': [2972], 'Egly': [2974], '90:': [2980], '97-107Abstract': [2981], '(259)': [2989], '35Wilkinson': [2992], 'M.G.': [2993], 'Millar': [2994], 'J.B.': [2995], 'Genes': [2996], 'Dev.': [2997], '1391-1397Crossref': [3000], '(72)': [3003], 'investigated': [3007, 3163], 'whether': [3008, 3164, 3942], 'changing': [3009], 'affects': [3015], 'Increased': [3021], 'decreased': [3023, 3338, 3377], 'either': [3031], 'homodimers': [3037], 'heterodimers': [3044, 3419], '4).': [3046], 'direct': [3052], 'independent': [3058], 'c-Jun': [3066], 'NH2-terminal': [3067], 'kinases': [3068, 3608], 'also': [3070, 3428, 3874], 'reported': [3072, 3824], '(28Adam-Stitah': [3081], 'Correlation': [3105], 'Arrest': [3110], 'Activity': [3117], 'Immunoprecipitates—To': [3120], 'provide': [3121], 'insight': [3122], 'consequence': [3126], 'RXR/CK1α': [3128, 3180, 3959], 'interaction,': [3129], 'increased': [3136], 'expression.': [3138], 'instances,': [3141], 'sensitivity': [3145], 'overexpressing': [3156], '5a).': [3161], 'association': [3166], 'governs': [3171], 'lines.': [3179], 'analysis.': [3193], '5c,': [3198], '(HEK293RXR': [3214], 'HeLaRXR)': [3216], 'activity.': [3219], 'AGN194204-sensitive': [3229], '(DT40RXR,': [3231], 'JurkatRXR,': [3232], 'HircRXR)': [3234], 'though': [3236], '5b).': [3242], 'results': [3244], 'imply': [3245], 'mediates': [3251], 'inactive': [3260], 'Level': [3268], 'Increases': [3273], 'Efficacy': [3274], 'Apoptosis—We': [3282], 'tested': [3283], 'agonist-resistant': [3288], 'rendered': [3292], 'down-regulating': [3298], '6a,': [3316, 3331, 3351], 'left': [3317], 'panel),': [3318], 'led': [3321], 'concomitant': [3324], 'middle': [3332], 'panel).': [3333, 3353], 'Importantly,': [3334, 3972], 'right': [3352], 'native': [3355], 'do': [3359], 'became': [3371], '6b,': [3379, 3404], 'first': [3380, 3606], 'panels).': [3382, 3407], 'addition,': [3384], 'CK1α-suppressed': [3389], 'resulted': [3392], 'caspases': [3397], 'last': [3405], 'key': [3410], 'regulation': [3413, 3439, 3614, 3788], 'forming': [3418], 'ligand-activated': [3423], 'There': [3426], 'suggestions': [3430], 'physiological': [3435], 'besides': [3437], '16Li': [3466], '18Liu': [3535], '19Xiao': [3565], 'Casein': [3599], 'one': [3603], 'discovered,': [3609], 'yet': [3610], 'function': [3612, 3995], 'poorly': [3616], 'understood.': [3617], 'represents': [3619], 'family': [3621], 'second': [3623], 'messenger-independent': [3624], 'Ser/Thr': [3625], 'mammals,': [3629], 'β,': [3631], 'γ,': [3632], 'δ,': [3633], 'ϵ': [3635], 'identified': [3638, 3676], 'cloned,': [3640], 'isoform': [3643], 'different': [3647], 'roles.': [3648], 'ubiquitously': [3651], 'expressed,': [3652], 'Scholar),': [3671], 'recently': [3674], 'component': [3680], 'controls': [3685], 'degradation.': [3689], 'Depletion': [3690], 'causes': [3693], 'accumulation': [3696], 'similar': [3700], 'caused': [3703], 'lack': [3706], 'functional': [3709], 'suppressor': [3711], 'adenomotous': [3713], 'polyposis': [3714], 'coli': [3715], 'interacts': [3754], 'interferes': [3763], 'agonist-driven': [3766], 'Interaction': [3775], 'does': [3780], 'transcription.': [3791], 'Recently,': [3792], 'Tanaka': [3793], 'et': [3794], 'al.': [3795], '(36Tanaka': [3796], 'Dancheck': [3798], 'B.L.': [3799], 'Trifiletti': [3800], 'L.C.': [3801], 'Birnkrant': [3802], 'R.E.': [3803], 'B.J.': [3805], 'Garfield': [3806], 'S.H.': [3807], 'Thorgeirsson': [3808], 'De': [3810], 'Luca': [3811], 'L.M.': [3812], '24:': [3817], '3972-3982Crossref': [3818], '(31)': [3821], 'agonist-unresponsive': [3828], 'MDA-MB-231': [3829], 'located': [3833], 'interchromatin': [3835, 3881, 3932, 3950], 'granule': [3836, 3882, 3933, 3951], 'clusters': [3837, 3883], 'forced': [3840], 'nucleoplasmic': [3841], 'agonist.': [3855], 'findings': [3857, 3974], 'suggest': [3858], 'altered': [3860], 'localization': [3861], 'coincides': [3864], 'loss': [3866], 'responsiveness.': [3870], 'Interestingly,': [3871], 'multiprotein': [3878], '37Gross': [3898], 'Loijens': [3900], '112:': [3908], '2647-2656Crossref': [3909], 'Therefore,': [3913], 'possible': [3916], 'process': [3925], 'sequestration': [3927], 'RXR·CK1α': [3930, 3945], 'clusters.': [3934, 3952], 'It': [3935], 'would': [3936], 'very': [3938], 'interesting': [3939, 3967], 'investigate': [3941], 'sequestered': [3948], 'exact': [3954], 'regulates': [3961], 'subjects': [3968], 'future': [3970], 'study.': [3971], 'our': [3973], 'add': [3975], 'new': [3976], 'insights': [3977], 'therapeutic': [3989], 'importance': [3990], 'inhibiting': [3993], 'activities': [4000]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2132495730', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 1}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2014, 'cited_by_count': 6}, {'year': 2013, 'cited_by_count': 1}], 'updated_date': '2024-12-10T02:55:58.864087', 'created_date': '2016-06-24'}