Publication Information

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2782, 2860, 2900, 2930, 3021, 3037, 3065, 3081, 3096, 3121, 3166, 3188, 3201, 3300, 3368, 3403, 3442, 3600, 3632, 3653, 3666, 3712, 3761, 3766, 3848, 3930, 4054, 4069, 4082, 4093, 4116, 4200, 4219, 4297], 'kringle': [13, 45, 58, 79, 87, 128, 209, 241, 254, 275, 283, 324, 399, 1814, 2093, 2412, 2588, 2592, 2765, 3992, 4208, 4262, 4292], 'domain-containing': [14, 210], 'fragments': [16, 212, 2470, 2502, 2583, 2609, 2630, 2735, 2784, 3348, 3382, 3529, 3555, 3986, 4222], 'have': [17, 213, 421, 687, 897, 1417, 2047, 2424, 2471, 3195], 'been': [18, 214, 480, 688, 843, 1042, 1114, 1787, 2425, 2472], 'analyzed': [19, 215, 3002, 3236, 3500, 3615], 'by': [20, 24, 117, 154, 171, 216, 220, 313, 350, 367, 727, 1044, 1345, 1561, 1580, 1789, 2177, 2230, 2295, 2335, 2616, 2792, 2916, 2926, 3110, 3138, 3501, 3545, 3616, 3684, 3700, 4268], 'solid-phase': [21, 217], 'immunoassays': [22, 218, 4081], 'surface': [25, 221, 891, 2070, 2226, 2717, 2791], 'plasmon': [26, 222, 2071, 2718], 'resonance.': [27, 223], 'In': [28, 224, 581, 2832, 2882, 3741], 'immunoassays,': [29, 225], 'core': [31, 227], 'protein': [32, 228, 1922], 'binds': [35, 231, 3982, 4250], 'specifically': [36, 232], 'saturably': [38, 234], 'to': [39, 53, 70, 85, 91, 115, 235, 249, 266, 281, 287, 311, 482, 838, 845, 848, 880, 905, 930, 996, 1019, 1030, 1123, 1302, 1336, 1340, 1462, 1464, 1475, 1589, 1677, 1759, 1769, 1932, 2053, 2080, 2086, 2101, 2125, 2252, 2277, 2392, 2725, 2747, 2755, 2768, 2797, 2810, 2869, 2973, 3125, 3131, 3158, 3175, 3285, 3293, 3304, 3420, 3512, 3689, 3838, 3984, 4098, 4104, 4204, 4206, 4216, 4251, 4284], 'plasminogen,': [40, 236, 1817, 3186, 3440, 3835, 4211], 'which': [41, 55, 237, 251, 1809, 2364, 3990, 4281], 'consists': [42, 238], 'five': [44, 240, 2987], 'domains': [46, 59, 80, 242, 255, 276, 1815, 2766, 4209, 4293], 'a': [48, 184, 244, 380, 433, 677, 717, 917, 961, 1004, 1481, 1548, 1772, 2296, 2375, 2821, 2842, 2852, 2861, 2866, 2872, 2883, 2891, 2897, 2906, 2957, 3047, 3066, 3112, 3132, 3140, 3145, 3196, 3286, 3493, 3625, 3690, 3831, 3840, 4356], 'serine': [49, 245, 2596, 4226], 'protease': [50, 98, 246, 294, 2597, 4227], 'domain,': [51, 247], 'angiostatin,': [54, 250, 1808, 3187, 3989], 'contains': [56, 252, 2562, 3972], '1–3.': [60, 256], 'Apparent': [61, 257], 'dissociation': [62, 102, 258, 298, 3038, 3067, 3085, 3167, 3255, 4087], 'constants': [63, 103, 259, 299, 3256, 4088], 'for': [64, 75, 194, 260, 271, 390, 828, 919, 963, 1353, 1550, 1775, 1798, 2254, 2268, 2331, 2342, 2410, 2628, 2729, 2979, 2991, 3011, 3023, 3074, 3116, 3129, 3180, 3352, 3371, 3397, 3541, 3547, 3569, 3671, 3977, 4072, 4089, 4101, 4360], 'these': [65, 176, 261, 372, 885, 2096, 2291, 2911, 3193, 3230, 3942, 4252], 'interactions': [66, 262, 2083, 2097, 4074, 4090], 'range': [67, 263, 2965], 'from': [68, 82, 264, 278, 913, 2417, 2461, 2575, 2580, 2602, 2612, 2679, 2688, 2694, 2705, 3028, 3090], '12': [69, 265], '75': [71, 267], 'nm.': [72, 268, 2384], 'Additional': [73, 269], 'evidence': [74, 270, 821, 1112, 1329], 'interaction': [77, 129, 133, 273, 325, 329, 1202, 2731, 2773, 3117, 3182], 'comes': [81, 277], 'its': [83, 279, 477], 'binding': [84, 114, 123, 280, 310, 319, 2067, 2077, 2727, 2750, 2909, 3155, 3163, 3178, 3259, 3289, 3415, 3477, 3975, 4070, 4103, 4276, 4288, 4358], 'domain': [88, 94, 284, 290, 2518, 2547, 2554, 2598, 4228], '4': [89, 285, 2589, 3350, 3356], 'miniplasminogen': [92, 288], '(kringle': [93, 289], '5': [95, 291, 2593, 4298], 'plus': [96, 292, 2262, 2594], 'domain)': [99, 295], 'apparent': [101, 297, 3083, 3254, 4086], 'in': [104, 127, 300, 323, 429, 493, 589, 696, 735, 739, 745, 764, 907, 921, 927, 965, 1023, 1028, 1116, 1126, 1306, 1409, 1540, 1682, 1777, 1802, 2198, 2246, 2257, 2271, 2300, 2363, 2398, 2505, 2952, 3212, 3229, 3237, 3265, 3377, 3384, 3394, 3425, 3556, 3578, 3598, 3624, 3663, 3724, 3755, 3763, 3843, 3936, 3941, 3954, 3960, 4291], '18–71': [106, 302], 'nm': [107, 303, 3491, 3651, 3706], 'range.': [108, 304], 'Inhibition': [109, 305], 'angiostatin': [113, 139, 164, 309, 335, 360, 1921, 2124, 2317, 2856, 3419, 3451, 3931], '6-aminohexanoic': [118, 314, 413, 2690, 3437], 'acid': [119, 315, 414, 2691, 3438], 'suggests': [120, 316, 822], 'that': [121, 317, 592, 722, 823, 899, 1131, 1419, 1557, 1792, 2084, 2287, 2378, 3016, 3150, 3920, 3966, 3998, 4257, 4271], 'lysine': [122, 318, 3435, 4287], 'sites': [124, 320, 997, 3976, 4289], 'are': [125, 321, 955, 1001, 1132, 1424, 3202, 3932, 4075, 4096, 4202], 'involved': [126, 322, 3754], 'NG2.': [131, 173, 327, 369, 3728], 'The': [132, 160, 328, 356, 486, 1296, 1452, 1671, 1920, 2385, 2559, 2622, 2875, 3190, 3232, 3533, 4085], 'has': [140, 336, 479, 842, 1041, 1113, 1766, 1786], 'very': [141, 337], 'interesting': [142, 338], 'functional': [143, 339, 2104, 4357], 'consequences.': [144, 340], '1)': [145, 341], 'Soluble': [146, 342], 'significantly': [148, 344], 'enhances': [149, 345], 'activation': [151, 347, 1136, 2116], 'urokinase': [155, 351, 405, 1584, 2570], 'type': [156, 352, 1210, 1299, 4117], 'activator.': [158, 354], '2)': [159, 355], 'antagonistic': [161, 357], 'effect': [162, 358], 'on': [165, 361, 888, 1134, 1411, 1467, 2088, 2787, 3097], 'endothelial': [166, 362, 685, 990, 1934, 2127, 2139, 2235, 3845], 'cell': [167, 189, 363, 385, 730, 890, 1024, 1127, 1304, 1400, 1935, 2128, 2140, 2225, 2282, 2353, 2840, 2850, 2864, 2878, 2888, 2894, 2901, 3245, 3846], 'proliferation': [168, 192, 364, 388, 1936, 2233, 2289, 2351, 3847], 'is': [169, 365, 432, 488, 498, 585, 721, 725, 903, 981, 1213, 1327, 1343, 1356, 1558, 1567, 1573, 1675, 1794, 1818, 1941, 2388, 3753, 3836, 4266, 4277, 4282], 'inhibited': [170, 366], 'soluble': [172, 368, 2733, 2752, 3119], 'Both': [174, 370, 1395, 3057], 'effects': [177, 373, 883, 968], 'should': [180, 376], 'make': [181, 377], 'positive': [185, 381], 'regulator': [186, 382], 'migration': [190, 386, 1130, 1305, 1938, 3849], 'required': [193, 389], 'angiogenesis.': [195, 391, 430, 683], 'platelet-derived': [392], 'growth': [393, 397, 839, 886, 924, 971, 1397, 1826, 1950], 'factor': [394, 398, 925, 985, 1681], 'basic': [395, 2761], 'fibroblast': [396], 'fetal': [400, 2205], 'calf': [401, 2206], 'serum': [402, 409, 2207], 'extracellular': [403, 1011, 1032, 1207, 1468, 1478, 2517, 3956, 4105], 'glycosaminoglycan': [404, 2511], 'activator': [407], 'bovine': [408], 'albumin': [410], 'phosphate-buffered': [411], 'saline': [412], 'Several': [415], 'observations': [416], 'concerning': [417], 'suggested': [422, 1043], 'possible': [424, 1773], 'involvement': [425, 3940], 'this': [427, 1354, 1782, 2044, 3675, 3962], 'molecule': [428, 1596], 'prominent': [434], 'component': [435, 731, 1209], 'vasculature': [437, 734], '(1Stallcup': [438, 1216], 'W.B.': [439, 464, 667, 750, 813, 859, 943, 1055, 1074, 1099, 1152, 1217, 1236, 1255, 1279, 1315, 1440, 2434, 2482, 2530, 3319], 'Dahlin': [440, 1218, 2523], 'K.': [441, 529, 606, 772, 1053, 1148, 1173, 1219, 1373, 1515, 1636, 1692, 4029, 4336], 'Healy': [442, 1220], 'P.': [443, 547, 624, 790, 1169, 1221, 1369, 1501, 1521, 1698, 2148, 4010, 4183], 'J.': [444, 465, 512, 535, 552, 612, 629, 778, 795, 860, 944, 1056, 1100, 1171, 1222, 1256, 1280, 1371, 1441, 1519, 1622, 1696, 1733, 1831, 1847, 1853, 1869, 1881, 1882, 1955, 1971, 1977, 1993, 2005, 2006, 2435, 2483, 2531, 3320, 3775, 3804, 3862, 3892, 3906, 3909, 4012, 4130, 4153, 4154, 4173, 4237, 4308, 4341, 4369, 4375], 'Cell': [445, 752, 945, 1185, 1223, 1317, 1385, 1490, 1661, 2133, 2532, 3820], 'Biol.': [446, 861, 1076, 1154, 1186, 1224, 1238, 1257, 1281, 1386, 1491, 1734, 1747, 1883, 2007, 2166, 2436, 2484, 2533, 3321, 3821, 4131, 4155, 4238, 4342], '1990;': [447, 537, 614, 780, 1225, 3797, 4344], '111:': [448, 1226], '3177-3188Crossref': [449, 1227], 'PubMed': [450, 471, 518, 557, 634, 757, 800, 871, 1062, 1081, 1106, 1159, 1190, 1228, 1243, 1267, 1291, 1322, 1390, 1447, 1495, 1509, 1532, 1606, 1626, 1666, 1709, 1726, 1742, 1857, 1893, 1915, 1981, 2017, 2039, 2170, 2446, 2494, 2537, 3331, 3781, 3800, 3825, 3868, 3900, 3914, 4017, 4037, 4139, 4163, 4177, 4196, 4246, 4313, 4328, 4350], 'Scopus': [451, 472, 519, 558, 635, 758, 801, 872, 1063, 1082, 1107, 1160, 1191, 1229, 1244, 1268, 1292, 1323, 1391, 1448, 1496, 1510, 1533, 1607, 1627, 1667, 1710, 1727, 1858, 1894, 1916, 1982, 2018, 2040, 2171, 2447, 2495, 2538, 3332, 3782, 3810, 3826, 3869, 3901, 3915, 4018, 4038, 4178, 4314, 4329], '(147)': [452, 1230], 'Google': [453, 474, 521, 540, 560, 579, 617, 637, 656, 673, 715, 760, 783, 803, 819, 874, 950, 1065, 1084, 1109, 1162, 1193, 1231, 1246, 1270, 1294, 1325, 1393, 1450, 1498, 1512, 1535, 1609, 1629, 1650, 1669, 1712, 1729, 1743, 1860, 1896, 1918, 1984, 2020, 2042, 2173, 2449, 2497, 2540, 3334, 3784, 3801, 3812, 3828, 3871, 3903, 3917, 4020, 4040, 4140, 4164, 4180, 4197, 4247, 4316, 4331, 4351], 'Scholar,': [454, 522, 541, 561, 618, 638, 657, 784, 1066, 1085, 1163, 1232, 1247, 1271, 1499, 1513, 1610, 1630, 1651, 1730, 1744, 1861, 1897, 1985, 2021, 3785, 3802, 3813, 3872, 3904, 4021, 4041, 4141, 4165, 4181, 4317, 4332], '2Nishiyama': [455], 'A.': [456, 507, 509, 511, 941, 1091, 1150, 1234, 1275, 1277, 1313, 1616, 1653, 2478, 2480, 2522, 3791, 4149], 'Lin': [457], 'X.H.': [458, 1051, 1068], 'Giese': [459], 'N.': [460, 3907], 'Heldin': [461], 'C.H.': [462], 'Stallcup': [463, 666, 749, 812, 858, 942, 1054, 1073, 1098, 1151, 1235, 1254, 1278, 1314, 1439, 2433, 2481, 2529, 3318], 'Neurosci.': [466], 'Res.': [467, 575, 652, 669, 711, 753, 815, 1318, 1528, 1646, 1662, 1705, 1910, 2034], '1996;': [468, 554, 631, 797, 1059, 1078, 1259, 1885, 2009, 3865], '43:': [469], '299-314Crossref': [470], '(533)': [473], 'Scholar),': [475, 716, 761, 1110], 'where': [476, 998], 'expression': [478, 695], 'found': [481], 'be': [483, 826, 974, 1017, 1407, 1678, 2380, 3949], 'regulated.': [485], 'expressed': [489, 726, 1344], 'at': [490, 1575, 2243, 2382, 2673, 2942, 2956, 2986, 3349, 3355, 3400, 3489, 3550, 3668, 3704, 3717], 'high': [491, 2769, 3973], 'levels': [492, 2770, 2802, 3214, 3222, 3263], 'immature': [494], 'vessels': [495, 502], 'then': [497, 2266, 3369, 3404], 'down-regulated': [499], 'as': [500, 690, 1359, 1547, 2228, 2631, 2871, 2905, 3248, 3309, 3409, 3471, 3482, 3530, 3609, 3988, 4109, 4364], 'mature': [503, 582], '(3Miller': [504], 'B.': [505, 4008, 4025, 4371], 'Sheppard': [506], 'Bicknese': [508], 'Perlman': [510], 'Comp.': [513], 'Neurol.': [514], '1995;': [515, 754, 1623, 3911], '355:': [516], '615-628Crossref': [517], '(94)': [520], '4Schlingemann': [523], 'R.': [524, 543, 601, 620, 661, 767, 786, 807, 1095, 1253, 2156, 3789], 'Rietvold': [525, 602, 768], 'F.': [526, 549, 603, 626, 769, 792], 'De': [527, 604, 770], 'Wall': [528, 605, 771], 'Ferrone': [530, 607, 773], 'S.': [531, 608, 774, 1093, 1714, 1873, 1997, 2154, 4047, 4187], 'Ruiter': [532, 550, 609, 627, 775, 793], 'D.': [533, 551, 610, 628, 776, 794, 939, 1087, 1146, 1867, 1871, 1991, 1995, 3774, 4062, 4306, 4367], 'Am.': [534, 611, 777], 'Pathol.': [536, 553, 613, 630, 779, 796], '136:': [538, 615, 781], '1393-1405PubMed': [539, 616, 782], '5Schlingemann': [542, 619, 785], 'Oosterwijk': [544, 621, 787], 'E.': [545, 622, 665, 788, 811, 1097, 1177, 1251, 1377, 1716, 2146], 'Wesseling': [546, 623, 789], 'Rietveld': [548, 625, 791], '179:': [555, 632, 798], '436-442Crossref': [556, 633, 799], '(69)': [559, 636, 802], '6Schrappe': [562, 639], 'M.': [563, 640, 699, 1089, 1167, 1367, 1638, 1640, 1642, 1845, 1879, 1969, 2003, 2144, 2150, 2152, 2162, 3793, 3884, 4023, 4027, 4323, 4340], 'Klier': [564, 641, 700], 'F.G.': [565, 642, 701], 'Spiro': [566, 643, 702], 'R.C.': [567, 644, 703], 'Waltz': [568, 645, 704], 'T.A.': [569, 646, 705], 'Reisfeld': [570, 647, 706], 'R.A.': [571, 648, 707, 1849, 1973, 3882], 'Gladson': [572, 649, 708], 'C.L.': [573, 650, 709], 'Cancer': [574, 651, 668, 710, 814, 1527, 1600, 1645, 1704], '1991;': [576, 653, 712, 2534, 3778, 4325], '51:': [577, 654, 713], '4986-4993PubMed': [578, 655, 714], 'Scholar).': [580, 951, 1194, 1295, 1394, 1451, 1536, 1670, 1919, 2450, 2498, 3335, 3829, 3918, 4065, 4198, 4248, 4352], 'animals': [583], 'once': [586], 'again': [587, 2903, 3614], 'up-regulated': [588], 'neovasculature': [591, 697], 'develops': [593], 'during': [594, 986, 3018, 3850], 'tumor': [595, 1455, 1825, 1949], 'formation': [596], 'wound': [598], 'healing': [599], '(4Schlingemann': [600, 766], '7Burg': [658], 'M.A.': [659, 805, 855, 1072, 1144, 1249, 1311, 1436, 2430, 3315], 'Pasqualini': [660, 806], 'Arap': [662, 808], 'W.': [663, 809, 4304], 'Ruoslahti': [664, 810], '1999;': [670, 816, 863, 947, 1156, 1187, 1387, 1912, 2036, 2438, 3323], '59:': [671, 817], '2869-2874PubMed': [672, 818], 'Scholar)': [674, 875, 1326, 2174], 'further': [675, 1328], 'supporting': [676], 'relationship': [678], 'between': [679, 2732, 3118, 3153, 4091], 'Although': [684], 'cells': [686, 744, 834, 911, 991, 1351, 1456, 1539, 1566, 2221, 2236, 2292, 2330, 2370, 2397, 2827, 3239], 'proposed': [689], 'one': [691, 2833, 2889, 3240], 'source': [692], '(6Schrappe': [698], 'more': [718, 1429, 3407, 3586], 'likely': [719], 'possibility': [720], 'mesenchymal': [729], 'question:': [736], 'i.e.': [737], 'cardiomyocytes': [738], 'heart,': [741], 'smooth': [742, 909], 'muscle': [743, 910], 'arteries': [746], '(8Grako': [747], 'K.A.': [748, 857, 935, 1070, 1438, 2432, 3317], 'Exp.': [751, 1316, 1660], '221:': [755], '231-240Crossref': [756], '(93)': [759], 'pericytes': [763, 993], 'microvessels': [765], 'Scholar,7Burg': [804], 'Scholar).Current': [820], 'may': [825, 878, 1016], 'important': [827, 957, 976, 984, 1680], 'controlling': [829], 'both': [830, 956, 989, 1010, 1425, 1562, 1760, 2081, 2107, 3764, 4078, 4213], 'motility': [832, 980, 1027, 1401, 1453], 'their': [836, 889, 1432, 1460, 1473, 1552, 3939], 'responsiveness': [837], 'factors.': [840], 'shown': [844, 898, 1418], 'bind': [846, 4205, 4215], 'directly': [847, 2390], 'PDGF-AA1': [849], 'bFGF': [851, 954], '(9Goretzki': [852, 2427, 3312], 'L.': [853, 1175, 1179, 1375, 1379, 1525, 1702, 2158, 2160, 2428, 3313, 3858, 3876, 4043], 'Burg': [854, 1071, 1143, 2429, 3314], 'Grako': [856, 1069, 1437, 2431, 3316], 'Chem.': [862, 1258, 1282, 1735, 1884, 2008, 2437, 2485, 3322, 4132, 4156, 4239, 4343], '274:': [864, 2439, 3324], '16831-16837Abstract': [865, 2440, 3325], 'Full': [866, 868, 1262, 1264, 1286, 1288, 1723, 1739, 1888, 1890, 2012, 2014, 2441, 2443, 2489, 2491, 3326, 3328, 3897, 4136, 4160, 4243, 4347], 'Text': [867, 869, 1263, 1265, 1287, 1289, 1724, 1740, 1889, 1891, 2013, 2015, 2442, 2444, 2490, 2492, 3327, 3329, 3898, 4137, 4161, 4244, 4348], 'PDF': [870, 1266, 1290, 1725, 1741, 1892, 2016, 2445, 2493, 3330, 3899, 4138, 4162, 4245, 4349], '(168)': [873, 1192, 1392, 2448, 3333], 'thus': [877, 1940], 'serve': [879, 2870], 'modulate': [881, 2102], 'factors': [887, 972], 'signaling': [892, 932], 'receptors.': [893], 'For': [894, 1414, 2312, 2815, 3412], 'example,': [895, 1415], 'we': [896, 1416, 2046, 2074, 2819, 3169, 3964], 'PDGF-α': [901], 'receptor': [902, 933], 'unresponsive': [904], 'PDGF-AA': [906], 'aortic': [908, 2138], 'derived': [912], 'NG2-null': [914], 'mice,': [915], 'suggesting': [916, 4256], 'role': [918, 962, 1774, 3842], 'sequestering': [922], 'or': [926, 2318, 3144, 3380, 3418, 3465, 3527, 3659, 3958], 'presenting': [928], 'it': [929, 4258], '(10Grako': [934], 'Ochiya': [936], 'T.': [937, 1614, 1644, 4147, 4185, 4334], 'Barritt': [938, 1145], 'Nishiyama': [940, 1149, 1276, 1312, 2479], 'Sci.': [946], '112:': [948], '905-915PubMed': [949], 'PDGF': [952], 'angiogenic': [958, 1803], 'mitogens,': [959], 'so': [960], 'modulating': [966], 'would': [973], 'an': [975, 983, 1201, 1307, 1679, 1819, 1943, 3058], 'aspect': [977], 'neovascularization.Cell': [979], 'also': [982, 1357, 1472, 1544, 1795, 1942, 3170, 3227, 3739, 3981, 4259], 'angiogenesis,': [987], 'because': [988, 2758, 4212], 'migrate': [994, 1466], 'rapidly': [995], 'capillary': [999], 'beds': [1000], 'expanding.': [1002], 'As': [1003], 'membrane-spanning': [1005], 'molecule,': [1006], 'interacts': [1008, 4260], 'intracellular': [1013], 'components': [1014, 1470, 4107], 'able': [1018], 'trigger': [1020], 'cytoskeleton-dependent': [1021], 'changes': [1022, 1125], 'morphology': [1025], 'response': [1029, 3262], 'environment.': [1033], 'An': [1034], 'association': [1035, 3036, 3059, 3165], 'cytoskeleton': [1040], 'several': [1045], 'distinct': [1046], 'lines': [1047], 'investigation': [1049], '(11Lin': [1050], 'Dahlin-Huppe': [1052, 1147], 'Cell.': [1057, 1077, 1101, 1155, 1239, 1442, 1719, 3893], 'Biochem.': [1058, 1102, 1908, 2032, 4013, 4172, 4309, 4376], '63:': [1060], '463-477Crossref': [1061], '(56)': [1064], '12Lin': [1067], 'Mol.': [1075, 1153, 1237], '7:': [1079], '1977-1993Crossref': [1080], '(34)': [1083, 4179], '13Barritt': [1086], 'Pearn': [1088], 'Zisch': [1090], 'Lee': [1092], 'Javier': [1094], 'Pasquale': [1096], '2000;': [1103], '79:': [1104, 3895], '213-224Crossref': [1105], '(82)': [1108, 1324], 'presented': [1115], 'support': [1117], 'ability': [1120, 1297, 1461, 1474, 1931, 2050, 2122], 'initiate': [1124], 'shape': [1128], 'dependent': [1133], 'Rho': [1138], 'family': [1139], 'GTPases': [1140], '(14Fang': [1141], 'X.': [1142, 1839, 1963], '10:': [1157], '3373-3387Crossref': [1158], '(75)': [1161, 4019], '15Eisenmann': [1164], 'K.M.': [1165, 1365], 'Simpson': [1166, 1366], 'Keely': [1168, 1368], 'Guan': [1170, 1370], 'Tachibana': [1172, 1372], 'Lim': [1174, 1374], 'Manser': [1176, 1376], 'Furcht': [1178, 1378], 'Iida': [1180, 1380], 'J': [1181, 1381], 'McCarthy': [1182, 1382], 'J.B.': [1183, 1383], 'Nat.': [1184, 1384, 3863], '1:': [1188, 1388], '507-513Crossref': [1189, 1389], 'On': [1195], 'exterior': [1197], 'cell,': [1200], 'matrix': [1208, 1469, 1479, 4106], 'VI': [1211, 1300], 'collagen': [1212, 1301, 4119], 'well': [1214], 'documented': [1215], '16Nishiyama': [1233], '1993;': [1240, 1506, 1750, 4240], '4:': [1241, 3823], '1097-1108Crossref': [1242], '(84)': [1245], '17Burg': [1248], 'Tillet': [1250], 'Timpl': [1252], '271:': [1260, 1886, 2010], '26110-26116Abstract': [1261], '(172)': [1269], '18Tillet': [1272], 'E.F.': [1273, 1612, 2476], 'Ruggiero': [1274, 2477], '1997;': [1283, 1319, 1492, 2167, 2486], '272:': [1284, 2487], '10769-10776Abstract': [1285, 2488], '(134)': [1293, 2496], 'promote': [1303], 'NG2-dependent': [1308], 'fashion': [1309], '(19Burg': [1310], '235:': [1320], '254-264Crossref': [1321], 'capacity': [1332], 'mediate': [1337], 'cellular': [1338], 'responses': [1339], 'environment.NG2': [1342], 'majority': [1347], 'melanoma': [1350, 1362, 1412, 1762], 'reason': [1355], 'known': [1358, 1676, 4283], '(15Eisenmann': [1364], 'control': [1398, 3921], 'aspects': [1402], 'function': [1405, 1780, 2059], 'can': [1406, 2379], 'seen': [1408], 'studies': [1410], 'progression.': [1413], 'mouse': [1420, 2137, 2406, 2457], 'melanomas': [1421], 'expressing': [1422], 'faster': [1426], 'growing': [1427], 'metastatic': [1430], 'than': [1431, 3207], 'NG2-negative': [1433], 'counterparts': [1434], '(20Burg': [1435], 'Physiol.': [1443, 1504], '1998;': [1444, 1854, 1978, 3807], '177:': [1445], '299-312Crossref': [1446], '(101)': [1449], 'involves': [1457], 'not': [1458, 2223, 2745, 2880, 3136], 'only': [1459], 'adhere': [1463], 'but': [1471], 'degrade': [1476], 'using': [1480, 2357, 3003, 3139, 3164, 3480, 3504, 3638, 4077], 'number': [1482, 2394], 'different': [1484, 2500, 2988, 3429], 'proteases': [1485], '(21Chapman': [1486], 'H.A.': [1487], 'Curr.': [1488], 'Opin.': [1489], '9:': [1493, 1624, 1721], '714-724Crossref': [1494], '(421)': [1497], '22Mignatti': [1500], 'Rifkin': [1502, 3816], 'D.B.': [1503, 3817], 'Rev.': [1505, 1602, 3819], '73:': [1507, 4194], '161-195Crossref': [1508], '(1179)': [1511], '23Danø': [1514], 'Andreasen': [1516, 1693], 'P.A.': [1517, 1694, 1851, 1975], 'Grøndahl-Hansen': [1518, 1695], 'Kristensen': [1520, 1697], 'Nielsen': [1522, 1699], 'L.S.': [1523, 1700, 4151], 'Skriver': [1524, 1701], 'Adv.': [1526, 1703], '1985;': [1529, 1706, 4133, 4157], '44:': [1530, 1707], '139-166Crossref': [1531, 1708], '(2291)': [1534, 1711], 'Highly': [1537], 'motile': [1538], 'normally': [1541], 'developing': [1542], 'tissues': [1543, 3768], 'utilize': [1545], 'proteolysis': [1546], 'tool': [1549], 'enhancing': [1551], 'migration.': [1553], 'One': [1554], 'proteolytic': [1555, 3832], 'mechanism': [1556], 'commonly': [1559], 'used': [1560, 2504, 2724, 2820, 3171, 3228, 3470], 'normal': [1563, 3765], 'neoplastic': [1565], 'system,': [1570], 'wherein': [1571], 'cleaved': [1574], 'Arg561-Val562': [1577], 'peptide': [1578], 'bond': [1579], 'action': [1582, 1672], 'tissue': [1586], 'activators': [1588], 'yield': [1590, 3033], 'proteolytically': [1592], 'active': [1593], 'two': [1594, 2895], 'chain': [1595], 'plasmin': [1597, 1674, 2698, 3681, 3701, 3747], '(24Kwaan': [1598], 'H.C.': [1599], 'Metastasis': [1601], '1992;': [1603, 1663, 4174], '11:': [1604], '291-311Crossref': [1605], '(190)': [1608], '25Plow': [1611], 'Herren': [1613], 'Redlitz': [1615], 'Miles': [1617], 'L.A.': [1618, 1746], 'Hoover-Plow': [1619], 'J.L.': [1620], 'FASEB': [1621, 1852, 1976], '939-945Crossref': [1625], '(380)': [1628], '26Kobayashi': [1631], 'H.': [1632, 1634, 1837, 1961, 3795], 'Shinohara': [1633], 'Takeuchi': [1635], 'Itoh': [1637], 'Fujie': [1639], 'Saitoh': [1641], 'Terrao': [1643], '1994;': [1647, 3894], '54:': [1648], '844-849PubMed': [1649], '27Meissauer': [1652], 'Kramer': [1654, 1848, 1972], 'M.D.': [1655], 'Schirmmacher': [1656], 'V.': [1657], 'Brunner': [1658], 'G.': [1659], '199:': [1664], '179-190Crossref': [1665], '(47)': [1668], 'many': [1683, 3019], 'developmental': [1684], 'processes,': [1685], 'including': [1686], 'neovascularization': [1687], 'vascular': [1689], 'remodeling': [1690], '(23Danø': [1691], 'Scholar,28Strickland': [1713], 'Reich': [1715], 'Sherman': [1717], 'M.I.': [1718], '1976;': [1720], '231-240Abstract': [1722], '(420)': [1728], '29Highsmith': [1731], 'R.F.': [1732], '1981;': [1736], '256:': [1737], '6788-6795Abstract': [1738], '30Miles': [1745], 'Clin.': [1748, 3776], 'Hematol.': [1749], '15:': [1751], '107-115Google': [1752], 'Scholar).The': [1753], 'commonality': [1754], 'plasmin(ogen)': [1758], 'angiogenesis': [1764, 1823, 1947, 3854], 'systems': [1765], 'led': [1767], 'us': [1768], 'speculate': [1770], 'about': [1771], 'mediating': [1778], 'protease.': [1783], 'Our': [1784], 'curiosity': [1785], 'heightened': [1788], 'fact': [1791, 4270], 'precursor': [1797], 'another': [1799], 'key': [1800, 3841], 'player': [1801], 'mechanisms,': [1804], 'namely': [1805], 'angiostatin.': [1806, 2063], 'Full-length': [1807], 'comprises': [1810], 'first': [1812, 2838], 'four': [1813, 2826, 3246], 'endogenous': [1820], 'inhibitor': [1821], '(31Ji': [1827, 1951], 'W.R.': [1828, 1952], 'Castellino': [1829, 1953], 'F.,': [1830, 1954], 'Chang': [1832, 1956], 'Y.': [1833, 1863, 1905, 1957, 1987, 2029, 3878, 3888], 'Deford': [1834, 1958], 'M.E.': [1835, 1841, 1959, 1965], 'Gray': [1836, 1960], 'Villarreal': [1838, 1962], 'Kondri': [1840, 1964], 'Marti': [1842, 1870, 1966, 1994], 'D.M.': [1843, 1967], 'Llinas': [1844, 1878, 1968, 2002, 4322, 4339], 'Schaller': [1846, 1868, 1970, 1992, 4368], 'Trail': [1850, 1974], '12:': [1855, 1979, 3808], '1731-1738Crossref': [1856, 1980], '(123)': [1859, 1983], '32Cao': [1862, 1986], 'Ji': [1864, 1988], 'W-R.': [1865, 1989], 'Davidson': [1866, 1990], 'Söhndel': [1872, 1996], 'McCane': [1874, 1998], 'S.G.': [1875, 1999], "O'Reilly": [1876, 2000], 'M.S.': [1877, 2001, 3856, 3874, 4167, 4236], 'Folkman': [1880, 2004, 3861, 3891], '29461-29467Abstract': [1887, 2011], '(373)': [1895, 2019], '33McDonald': [1898, 2022], 'N.J.': [1899, 2023], 'Murad': [1900, 2024], 'A.C.': [1901, 2025], 'Fogler': [1902, 2026], 'W.E.': [1903, 2027], 'Lu': [1904, 2028], 'Sim': [1906, 2030], 'B.K.L.': [1907, 2031], 'Biophys.': [1909, 2033], 'Commun.': [1911, 2035], '264:': [1913, 2037], '469-477Crossref': [1914, 2038], '(51)': [1917, 2041], 'consisting': [1923], 'kringles': [1926, 2585], '1–3': [1927, 2413, 2586], '(K1–3)': [1928], 'retains': [1929], 'inhibit': [1933, 2126], 'effective': [1944], 'antagonist': [1945], 'Scholar).In': [2043], 'study': [2045, 3963], 'assessed': [2048], 'interact': [2054], 'affect': [2057], 'Using': [2064, 2711], 'solid': [2065, 4079], 'phase': [2066, 4080], 'assays': [2068], 'resonance': [2072, 2806, 3224], 'technology,': [2073], 'demonstrate': [2075], 'strong': [2076, 4272], 'molecules,': [2082], 'appear': [2085, 2100], 'depend': [2087], 'presence': [2090, 3427], 'domains.': [2094, 4263], 'Moreover,': [2095], 'properties': [2105], 'molecules.': [2108], 'Incubation': [2109], 'purified': [2111, 3346], 'accelerates': [2113], 'urokinase-dependent': [2115], 'diminishes': [2120], 'proliferation.EXPERIMENTAL': [2129], 'PROCEDURESCell': [2130], 'Culture': [2131], 'Proliferation': [2134], 'AssaysThe': [2135], 'Balb/c': [2136], 'line': [2141], '22106': [2142], '(34Bastaki': [2143], 'Nelli': [2145], "Dell'Era": [2147], 'Rusnati': [2149], 'Molinari-Tosatti': [2151], 'Parolini': [2153], 'Auerbach': [2155, 2189], 'Ruco': [2157], 'Possaati': [2159], 'Presta': [2161], 'Arterioscl.': [2163], 'Thromb.': [2164], 'Vasc.': [2165], '17:': [2168], '454-464Crossref': [2169], '(102)': [2172], 'was': [2175, 2293, 2325, 2355, 2686, 2692, 2703, 2723, 2879, 2924, 3001, 3088, 3283, 3423, 3452, 3478, 3604, 3622, 3682, 3702, 3749], 'provided': [2176], 'Drs.': [2178], 'Yu': [2179], 'Yamaguchi': [2180], '(The': [2181], 'Burnham': [2182], 'Institute,': [2183], 'La': [2184], 'Jolla,': [2185], 'CA)': [2186], 'Robert': [2188], '(University': [2190], 'Wisconsin,': [2192], 'Madison,': [2193], 'WI).': [2194], 'Cells': [2195, 2249], 'were': [2196, 2237, 2250, 2415, 2459, 2503, 2578, 2600, 2610, 2676, 2785, 2808, 2914, 2946, 2971, 2984, 3043, 3072, 3106, 3135, 3226, 3235, 3275, 3307, 3343, 3392, 3444, 3469, 3487, 3499, 3520, 3535, 3567, 3590, 3613, 3661, 3722, 3738], 'maintained': [2197], "Dulbecco's": [2199, 2258, 2273, 2301], 'modified': [2200, 2259, 2274, 2302], "Eagle's": [2201, 2260, 2275, 2303], 'medium': [2202, 2261, 2276, 2304, 2341], 'containing': [2203, 2305, 3363, 3389, 3558, 3580, 3646, 3731], '10%': [2204, 2263], '(FCS),': [2208], '2': [2209, 2548, 3398, 3548, 3570], 'mm': [2210, 2661, 2667, 3630, 3634], 'glutamine,': [2211], '100': [2212, 2216, 3385, 3633], 'IU/ml': [2213], 'penicillin,': [2214], 'μg/ml': [2217, 3351, 3524], 'streptomycin': [2218], 'sulfate.': [2219], 'These': [2220, 2608, 3031, 3946], 'do': [2222], 'express': [2224], 'determined': [2229, 2356], 'immunofluoresence': [2231], 'microscopy.For': [2232], 'experiments,': [2234, 2836, 2887, 3414], 'harvested': [2238], 'trypsin-EDTA': [2240], 'seeded': [2242], '2000': [2244], 'cells/well': [2245], '96-well': [2247, 3337, 3517, 3664], 'plates.': [2248], 'allowed': [2251], 'recover': [2253], '8': [2255], 'h': [2256, 2270, 2333, 3354, 3373, 3399, 3549, 3571], 'FCS': [2264, 2307], 'incubated': [2267, 2326, 3393, 3568, 3591, 3667, 3723], '24': [2269, 3353], 'serum-free': [2272], 'allow': [2278], 'synchronization': [2279], 'cycle.': [2283], 'Preliminary': [2284], 'experiments': [2285], 'established': [2286], 'optimal': [2288], 'achieved': [2294, 3264], '72-h': [2297, 2344, 2350], 'incubation': [2298, 3546, 3716], 'period': [2299, 2345], '5%': [2306], '10': [2309, 3650, 3672], 'ng/ml': [2310], 'bFGF.': [2311], 'determining': [2313], 'inhibition': [2314, 3413, 4273], 'proliferation,': [2316], '(along': [2320], 'when': [2323], 'indicated)': [2324], 'starved': [2329], '1': [2332, 2919, 3372, 3732], 'followed': [2334, 3544], 'addition': [2337, 3157, 3686], 'FCS/bFGF-containing': [2340], 'stimulation.': [2347], 'After': [2348, 3561, 3584, 3674], 'period,': [2352, 3677], 'density': [2354, 2387], 'CellTiter': [2359], '96': [2360], 'assay': [2361], '(Promega),': [2362], 'metabolic': [2366], 'activity': [2367, 3603, 3621, 3927], 'viable': [2369], 'converts': [2371], 'tetrazolium': [2372], 'dye': [2373], 'into': [2374], 'formazan': [2376], 'product': [2377], 'detected': [2381, 3445, 3453], '490': [2383], 'optical': [2386], 'therefore': [2389, 3203, 3933], 'proportional': [2391], 'living': [2396], 'wells.AntibodiesRabbit': [2400], 'antibody': [2401, 2408, 3456, 3476], 'against': [2402, 2422, 2454, 3277, 3457, 3575], 'monoclonal': [2407, 3455], 'specific': [2409], 'region': [2414, 3269], 'purchased': [2416, 2693, 2704], 'Calbiochem.': [2418, 2581], 'Affinity-purified': [2419], 'rabbit': [2420, 2455, 3447], 'antibodies': [2421, 2453, 3574], 'described': [2426, 2474, 3310, 3410, 3531, 3610], 'Peroxidase-labeled': [2451], 'goat': [2452, 3595], 'immunoglobulins': [2458], 'obtained': [2460, 2579, 2601, 2678, 2687, 2985, 3073, 3089, 4278], 'Bio-Rad.Purified': [2462], 'ProteinsThe': [2463], 'production': [2464, 3679], 'characterization': [2466], 'recombinant': [2468, 2939], 'previously': [2473, 3311], '(18Tillet': [2475], 'Four': [2499], 'our': [2506, 3103], 'experiments:': [2507], 'NG2/EC−': [2508, 3184], '(extracellular)': [2509], 'without': [2510], '(GAG)': [2512], 'chains,': [2513, 2565], 'comprising': [2514], 'entire': [2516, 3076], '(residues': [2519], '1–2223': [2520], '(35Nishiyama': [2521], 'K.J.': [2524], 'Prince': [2525], 'J.T.': [2526], 'Johnstone': [2527], 'S.R.': [2528], '114:': [2535], '359-371Crossref': [2536], '(230)': [2539], 'Scholar));': [2541], 'NG2/EC+': [2542], 'GAG': [2544], 'chains;': [2545], 'central': [2546], '(NG2/D2,': [2549], 'residues': [2550, 2557], '632–1450);': [2551], 'membrane-proximal': [2553], '3': [2555, 3523], '(NG2/D3,': [2556], '1587–2218).': [2558], 'NG2/D2': [2560], 'preparation': [2561], 'whereas': [2566, 3449], 'NG2/D3': [2567, 3660], 'does': [2568], 'not.Human': [2569], '(u-PA)': [2571], '(glu-type)': [2574], 'plasma': [2577], 'Plasminogen': [2582, 3379, 3514], 'representing': [2584], '(K1–3),': [2587, 2633], '(K4),': [2590, 2635], '(miniplasminogen)': [2599], 'American': [2603], 'Diagnostica': [2604], 'Inc.': [2605], '(Greenwich,': [2606], 'CT).': [2607], 'generated': [2611], 'glu-type': [2614], 'limited': [2617], 'digestion': [2618], 'pancreatic': [2620], 'elastase.': [2621], "manufacturer's": [2623, 2799], 'protocol': [2624], 'specifies': [2625], 'molecular': [2626], 'masses': [2627], '31.5': [2632], '14': [2634], '38': [2637], 'kDa': [2638], '(miniplasminogen).ReagentsResearch': [2639], 'grade': [2640], 'CM5': [2641, 3209], 'SensorChips': [2642], '(carboxymethylated': [2643], 'dextran': [2644], 'matrix),': [2645], 'Pioneer': [2646, 3172], 'B1': [2647, 3173], 'chips': [2648, 2913, 3174, 3194, 3234], 'reduced': [2650], 'negative': [2651], 'charge,': [2652], 'amine-coupling': [2653, 2794], 'kit': [2654], '[N-ethyl-N′-dimethylaminopropyl)': [2655], 'carbodiimide/N-hydroxysuccinimide],': [2656], 'HBS': [2658], 'buffer': [2659, 3626], '(10': [2660], 'HEPES': [2662], '0.15M': [2664], 'NaCl,': [2665, 3635], '3.4': [2666], 'EDTA,': [2668], '0.005%': [2670], 'surfactant': [2671], 'P20': [2672], 'pH': [2674, 2954, 3636], '7.4)': [2675], 'all': [2677, 2816, 2825], 'BIAcore': [2680, 2715, 2830, 4083], 'AB': [2681, 2707], '(Uppsala,': [2682], 'Sweden).': [2683], 'TurboTMB': [2684], '(3,3′,5,5′-tetramethylbenzidine)': [2685], 'Pierce,': [2689], 'Sigma,': [2695], 'substrate': [2699, 3641, 3699], 'S-2251': [2700, 3688], '(H-d-valyl-l-leucyl-l-lysine-p-nitroanilide': [2701], 'dihydrochloride)': [2702], 'Chromogenix': [2706], '(Mölndal,': [2708], 'Sweden).Kinetic': [2709], 'Measurements': [2710], 'Surface': [2712], 'Plasmon': [2713], 'ResonanceA': [2714], '3000': [2716], 'resonance-based': [2719], 'biosensor': [2720], '(BIAcore': [2721], 'AB)': [2722], 'measure': [2726, 2748], 'parameters': [2728], '(analytes)': [2736], 'various': [2738], 'immobilized': [2739, 2756, 2786, 2809, 3122, 3421], 'species': [2741, 2754, 2941, 4095], '(ligands).': [2742], 'We': [2743], 'did': [2744], 'attempt': [2746], 'NG2,': [2757], 'extremely': [2760], 'nature': [2762], 'leads': [2767], 'nonspecific': [2772, 3216], 'negatively': [2776, 3205], 'charged': [2777, 3206], 'sensor': [2778, 2789], 'chips.': [2779], 'Instead,': [2780], 'chip': [2790, 2843, 2853, 2868], 'method': [2795], 'according': [2796], 'instructions.': [2800], 'Low': [2801], 'ligand': [2804, 3220], '(<500': [2805], 'units)': [2807, 3225], 'minimize': [2811], 'mass': [2812, 3141], 'transfer': [2813], 'effects.': [2814], 'kinetic': [2817, 3104, 3160], 'measurements': [2818, 3020], 'flow': [2822, 2839, 2849, 2863, 2877, 2958, 3238, 3244], 'path': [2823], 'involving': [2824], '3000.': [2831], 'set': [2834, 2885, 2998, 3078], 'contained': [2841, 2851, 2865, 2890, 2896], 'coated': [2844, 2854, 2912, 2937, 2950, 3344, 3521], 'glu-plasminogen,': [2846, 3649], 'second': [2848, 2884, 3472], '(plasminogen': [2857], 'fragment': [2858, 3833], 'K1–3),': [2859], 'third': [2862], 'blank': [2867], 'reference': [2873, 3250], 'surface.': [2874, 3133, 3251], 'fourth': [2876], 'monitored.': [2881, 3740], 'K4-coated': [2892], 'chip,': [2893, 2899], 'miniplasminogen-coated': [2898], 'three': [2902, 3242, 3359, 3406, 3585], 'served': [2904], 'reference.': [2907], 'Between': [2908], 'cycles': [2910], 'regenerated': [2915], 'injection': [2917], 'm': [2920], 'NaCl.': [2921], 'Binding': [2922, 3298, 3303, 3511], 'specificity': [2923], 'checked': [2925], 'injecting': [2927], 'BSA': [2928, 3376, 3391, 3734], '(1.25': [2929], '2.5': [2931], 'μm)': [2932], 'over': [2933, 2948], 'each': [2934, 2992], 'chips.Purified': [2938], 'indicated': [2944], 'concentrations': [2945, 2968, 2990, 3430], 'injected': [2947], 'surfaces': [2951, 3191], 'HBS,': [2953], '7.4,': [2955], 'rate': [2959, 3060, 3068, 3098], '20': [2961, 3366, 3401, 3551], 'μl/min.': [2962], 'A': [2963, 3052], 'wide': [2964], 'analyte': [2967, 2989, 3120, 3278], '(∼1–10': [2969], '×KD)': [2970], 'applied': [2972], 'assure': [2974], 'recovery': [2975], 'data': [2977, 3077, 3105, 3179], 'suitable': [2978], 'curve': [2980], 'fitting.': [2981], 'Typically,': [2982], 'sensorgrams': [2983, 3000, 3027, 3042, 3272], 'analyte/ligand': [2995], 'pairs.': [2996], 'This': [2997, 3008, 3281, 4264], 'BIAevaluation': [3004], 'software': [3005, 3009, 3506], 'version': [3006], '3.0.': [3007], 'corrects': [3010], 'systematic': [3013], 'upward': [3014], 'drift': [3015], 'occurs': [3017], 'allows': [3022], 'subtraction': [3024], 'background': [3026], 'experimental': [3029], 'sensorgrams.': [3030], 'adjustments': [3032], 'corrected': [3034, 3041], 'sensorgrams.The': [3035], 'phases': [3039], 'fit': [3044, 3107, 3284], 'simultaneously,': [3045], 'assuming': [3046, 3111], 'simple': [3048, 3113], 'bimolecular': [3049, 3114], 'reaction': [3050], 'model:': [3051], '+': [3053], 'B': [3054], '↔': [3055], 'AB.': [3056], 'constant': [3061, 3069, 3086], 'ka': [3062], '(m−1': [3063], 's−1)': [3064], 'kd': [3070], '(s−1)': [3071], '(global': [3079], 'fit),': [3080], 'equilibrium': [3084, 3258], 'KD': [3087, 3295], 'ratio': [3092], 'off': [3095], 'constantskd': [3099], '/ka': [3100], '.': [3101], 'All': [3102], 'most': [3108], 'adequately': [3109], 'model': [3115, 3143, 3149], 'ligand,': [3123], 'equivalent': [3124], 'Langmuir': [3127], 'isotherm': [3128], 'adsorption': [3130], 'Fits': [3134], 'improved': [3137], 'transport': [3142], 'two-state': [3146], '(conformational': [3147], 'change)': [3148], 'assumes': [3151], 'cooperativity': [3152], 'multiple': [3154], 'sites.In': [3156], 'analysis': [3161], 'rates,': [3168], 'obtain': [3176], 'steady': [3177, 3267], 'miniplasminogen.': [3189], 'low': [3197, 3219], 'degree': [3198], 'carboxymethylation': [3200], 'less': [3204], 'chips,': [3210], 'resulting': [3211], 'lower': [3213], 'binding.': [3217], 'Very': [3218, 4066], 'immobilization': [3221], '(∼50': [3223], 'experiments.': [3231], 'ligand-coated': [3233], 'through': [3241], 'serving': [3247], 'To': [3252], 'derive': [3253], 'under': [3257], 'conditions,': [3260], 'peak': [3261], 'state': [3268], '(R': [3273], 'eq)': [3274], 'plotted': [3276], 'concentration': [3279, 3692], '(C).': [3280], 'plot': [3282], 'single': [3287], 'site': [3288, 4359], 'equation': [3290], '(Langmuir': [3291], 'isotherm)': [3292], 'determine': [3294], 'values.Solid': [3296], 'Phase': [3297], 'AssaysPlasminogen': [3299], 'Kringle': [3301], 'Domain': [3302], 'Immobilized': [3305, 3513], 'NG2Assays': [3306], 'performed': [3308], 'Briefly,': [3336], 'microtiter': [3338, 3495, 3518], 'plates': [3339, 3519, 3534, 3665], '(Greiner,': [3340], 'Nuertingen,': [3341], 'Germany)': [3342], '°C,': [3357], 'washed': [3358, 3405], 'times': [3360, 3408], 'PBS': [3362, 3388, 3557, 3579], '0.05%': [3364], 'Tween': [3365, 3582], '(PBST),': [3367], 'blocked': [3370, 3536], '1%': [3375, 3390, 3559], 'PBS.': [3378], 'dissolved': [3383, 3577], 'μl': [3386], 'wells': [3396, 3566, 3589], '°C': [3402, 3552, 3670], 'above.': [3411, 3532, 3611], 'measured': [3424, 3605, 3683], '(0.1–50': [3431], 'mm)': [3432], 'analog': [3436], '(6-AHA).Bound': [3439], 'miniplasminogen,': [3441], 'K4': [3443, 4220], 'anti-plasminogen,': [3448], 'bound': [3450, 3601], 'K1–3': [3460, 4218], 'fragment.': [3461], 'Horseradish': [3462], 'peroxidase-conjugated': [3463], 'anti-rabbit': [3464, 3596], 'anti-mouse': [3466], 'IgG,': [3467], 'respectively,': [3468], 'antibodies.': [3473], 'Quantitation': [3474], 'accomplished': [3479], '3,3′,5,5′-tetramethylbenzidine': [3481], 'peroxidase': [3484, 3602], 'substrate.': [3485], 'Plates': [3486], 'read': [3488], '450': [3490], 'Titertek': [3494], 'plate': [3496], 'reader.': [3497], 'Data': [3498, 3612], 'nonlinear': [3502, 3617], 'regression': [3503], 'PRISM': [3505], '(GraphPad,': [3507], 'San': [3508], 'Diego,': [3509], 'CA).NG2': [3510], 'SpeciesWells': [3515], 'Blocker': [3538], 'BLOTTO': [3539], '(Pierce)': [3540], '30': [3542], 'min,': [3543], 'BSA.': [3560], 'washing': [3562, 3608], 'PBST,': [3564], 'polyclonal': [3573], '0.02%': [3581], '20.': [3583], 'washes,': [3587], 'horseradish': [3593], 'peroxidase-labeled': [3594], 'IgG': [3597], 'PBS/BSA,': [3599], 'after': [3606, 3707], 'extensive': [3607], 'regression.Plasminogen': [3618], 'Activation': [3619], 'AssayPlasmin': [3620], 'quantified': [3623], 'composed': [3627], '50': [3629], 'Tris-HCl': [3631], '7.5,': [3637], 'chromogenic': [3640], 'S-2251.': [3642], 'Triplicates': [3643], 'samples': [3645, 3721, 3730], '0.15': [3647], 'μm': [3648, 3655, 3733], 'u-PA,': [3652, 3745], '0.5': [3654], 'NG2/EC−,': [3657], 'NG2/D2,': [3658], 'placed': [3662], '37': [3669, 3718], 'min.': [3673], 'preincubation': [3676], 'final': [3691], '0.3': [3694], 'mm.': [3695], 'Hydrolysis': [3696], 'monitored': [3703], '405': [3705], '30,': [3708], '60,': [3709], '120,': [3710], '180,': [3711], '240': [3713], 'min': [3714], '°C.': [3719], 'Reference': [3720], 'absence': [3726, 3743], 'Control': [3729], 'instead': [3735], 'no': [3746], 'generation': [3748], 'observed.DISCUSSIONThe': [3750], 'plasminogen/plasmin': [3751], 'system': [3752], 'regulation': [3757], 'development,': [3759], 'remodeling,': [3760], 'repair': [3762], 'pathological': [3767], '(39Vassalli': [3769], 'J.D.': [3770], 'Sappino': [3771], 'A.P.': [3772], 'Belin': [3773], 'Invest.': [3777], '88:': [3779], '1067-1072Crossref': [3780], '(1091)': [3783], '40Wilhelm': [3786], 'O.': [3787, 3815, 4145], 'Hafter': [3788], 'Henschen': [3790], 'Schmitt': [3792], 'Graeff': [3794], 'Blood.': [3796, 4192], '75:': [3798], '1673-1678Crossref': [3799], '41Félez': [3803], 'Fibrinolysis': [3805], 'Proteolysis.': [3806], '183-189Crossref': [3809], '(38)': [3811], '42Saksela': [3814], 'Annu.': [3818], '1988;': [3822], '93-126Crossref': [3824], '(714)': [3827], 'Angiostatin,': [3830], 'thought': [3837, 4203], 'play': [3839], 'regulating': [3844], 'process': [3852], "(43O'Reilly": [3855], 'Holmgren': [3857, 3875], 'Chen': [3859, 3879], 'C.': [3860, 3880], 'Med.': [3864, 3910], '2:': [3866], '689-692Crossref': [3867], '(1149)': [3870], "44O'Reilly": [3873], 'Shing': [3877], 'Rosenthal': [3881], 'Moses': [3883], 'Lane': [3885], 'W.S.': [3886], 'Cao': [3887], 'Sage': [3889], 'E.H.': [3890], '315-328Abstract': [3896], '(3150)': [3902], '45Folkman': [3905], 'Engl.': [3908], '333:': [3912], '1757-1763Crossref': [3913], '(2234)': [3916], 'Macromolecules': [3919], 'localization': [3923], 'and/or': [3924], 'regulate': [3925], 'interest': [3935], 'terms': [3937], 'same': [3943, 4253], 'biological': [3944], 'processes.': [3945], 'molecules': [3947, 4214], 'might': [3948], 'integral': [3950, 3968], 'membrane': [3951, 3969], 'components,': [3952], 'anchored': [3953], 'matrix,': [3957], 'free': [3959], 'solution.In': [3961], 'show': [3965], 'affinity': [3974], 'plasminogen.': [3979], 'tightly': [3983], 'such': [3987, 4108, 4363], 'contain': [3991], 'domains,': [3993], 'characteristic': [3995], 'disulfide-bonded': [3996], 'modules': [3997], 'occupy': [3999], 'N-terminal': [4001], 'two-thirds': [4002], 'polypeptide': [4006], '(46Wiman': [4007], 'Wallen': [4009], 'Eur.': [4011, 4307, 4374], '1975;': [4014], '50:': [4015], '489-494Crossref': [4016], '47Forsgren': [4022], 'Raden': [4024], 'Israelsson': [4026], 'Larsson': [4028], 'Helden': [4030], 'L.O.': [4031], 'FEBS': [4032], 'Lett.': [4033], '1987;': [4034], '213:': [4035], '254-260Crossref': [4036], '(154)': [4039], '48Sottrup-Jensen': [4042], 'Petersen': [4044], 'T.E.': [4045], 'Magnusson': [4046], 'Dayhoff': [4048], 'M.O.': [4049], 'Atlas': [4050], 'Protein': [4052], 'Sequence': [4053], 'Structure.': [4055], '5.': [4056], 'National': [4057], 'Biomedical': [4058], 'Research': [4059], 'Foundation,': [4060], 'Washington,': [4061], 'C.1978:': [4063], '91Google': [4064], 'similar': [4067], 'specificities': [4068], 'affinities': [4071], 'NG2/plasminogen': [4073, 4275], 'observed': [4076], 'measurements.': [4084], 'comparable': [4097], 'those': [4099], 'reported': [4100], 'fibronectin': [4110], '(91': [4111], 'nm),': [4112, 4115], 'thrombospondin': [4113], '(35': [4114], 'IV': [4118], '(12': [4120], 'nm)': [4121], '(49Silverstein': [4122], 'R.L.': [4123, 4125], 'Nachman': [4124], 'Leung': [4126], 'L.L.K.': [4127], 'Harpel': [4128], 'P.C.': [4129], '260:': [4134, 4158], '10346-10352Abstract': [4135], '50Salonen': [4142], 'E.M.': [4143], 'Saksela': [4144], 'Vario': [4146], 'Vaheri': [4148], 'Neilsen': [4150], 'Zeuthen': [4152], '12302-12307Abstract': [4159], '51Stack': [4166], 'Moser': [4168], 'T.L.': [4169, 4230], 'Pizzo': [4170, 4233], 'S.V.': [4171, 4234], '284:': [4175], '103-108Crossref': [4176], '52DePoli': [4182], 'Bacon-Baguley': [4184], 'Kendra-Franczak': [4186], 'Cederholm': [4188], 'M.T.': [4189], 'Walz': [4190], 'D.A.': [4191], '1989;': [4193], '976-982Crossref': [4195], 'Fibronectin': [4199], 'laminin': [4201], 'lacking': [4223], 'C-terminal': [4225], '(53Moser': [4229], 'Enghild': [4231], 'J.J.': [4232], 'Stack': [4235], '268:': [4241], '18917-18923Abstract': [4242], 'kringle-containing': [4254], 'fragments,': [4255], 'hypothesis': [4265], 'supported': [4267], '6-AHA,': [4280], 'block': [4285], 'present': [4290], '1,': [4294], '2,': [4295], '4,': [4296], '(54Lerch': [4299], 'P.G.': [4300], 'Rickli': [4301, 4372], 'E.E.': [4302, 4373], 'Lergier': [4303], 'Gillessen': [4305], '1980;': [4310], '107:': [4311], '7-13Crossref': [4312], '(183)': [4315], '55Rejante': [4318], 'M.R.': [4319], 'Byeon': [4320, 4337], 'I.-J.L.': [4321, 4338], 'Biochemistry.': [4324], '30:': [4326], '11081-11092Crossref': [4327], '(36)': [4330], '56Thewes': [4333], 'Constantine': [4335], '265:': [4345], '3906-3915Abstract': [4346], 'K3': [4353], 'apparently': [4354], 'lacks': [4355], 'zwitterionic': [4361], 'ligands': [4362], '6-AHA': [4365], '(57Marti': [4366], 'Ochsenberger': [4370], '199': [4377]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2132367917', 'counts_by_year': [{'year': 2022, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}, {'year': 2016, 'cited_by_count': 2}, {'year': 2015, 'cited_by_count': 4}, {'year': 2014, 'cited_by_count': 5}, {'year': 2013, 'cited_by_count': 2}], 'updated_date': '2024-12-12T03:13:03.310960', 'created_date': '2016-06-24'}