Increased faecal serine protease activity in diarrhoeic IBS patients: a colonic lumenal factor impairing colonic permeability and sensitivity

Name: Work Video:
Duration: 3 min 30 s
Krisztina Gecse; R Róka; Laurent Ferrier; Mathilde Lévêque; Hélène Eutamène; Christel Cartier; Afifa Ait-Belgnaoui; András Rosztóczy; F Izbéki; Jean Fioramonti; Tibor Wittmann; L. Bueno
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239], 'activity.': [14], 'The': [15, 136], 'aims': [16], 'of': [17, 26, 56, 157, 171, 176, 192, 223, 230, 241, 264], 'this': [18, 27, 66], 'study': [19], 'were': [20, 74, 131, 195], '(1)': [21], 'to': [22, 33, 40, 52, 92, 102, 210], 'investigate': [23], 'the': [24, 54, 57, 221, 262], 'origin': [25], 'activity,': [31], '(2)': [32], 'evaluate': [34], 'if': [35], 'it': [36, 166], 'may': [37], 'be': [38], 'sufficient': [39], 'trigger': [41], 'alterations': [42], 'in': [43, 65, 76, 108, 120, 139, 145, 182, 216, 220, 232, 254, 261], 'paracellular': [45], 'permeability': [46], '(CPP)': [47], 'and': [48, 50, 62, 69, 79, 85, 97, 110, 113, 126, 186, 201, 227, 251], 'sensitivity,': [49], '(3)': [51], 'examine': [53], 'role': [55], 'proteinase-activated': [58], 'receptor-2': [59], '(PAR-2)': [60], 'activation': [61], 'signalling': [63], 'cascade': [64], 'process.': [67], '<h3>Patients': [68], 'methods:</h3>': [70], 'Faecal': [71], 'enzymatic': [72], 'activities': [73], 'assayed': [75], 'healthy': [77], 'subjects': [78, 96], 'patients': [80, 147, 181, 214, 243], 'with': [81, 149, 168], 'IBS,': [82], 'ulcerative': [83], 'colitis': [84], 'acute': [86], 'infectious': [87, 154], 'diarrhoea.': [88], 'Following': [89], 'mucosal': [90], 'exposure': [91, 209], 'supernatants': [93, 178, 211], 'from': [94, 179, 212], 'control': [95], 'IBS-D': [98, 146, 180, 213, 242], 'patients,': [99], 'electromyographic': [100], 'response': [101], 'colorectal': [103], 'balloon': [104], 'distension': [105], 'was': [106, 115], 'recorded': [107], 'wild-type': [109], 'PAR-2<sup>–/–</sup>': [111], 'mice,': [112, 207, 255], 'CPP': [114, 188], 'evaluated': [116], 'on': [117, 203], 'strips': [119], 'Ussing': [121], 'chambers.': [122], 'Zonula': [123], 'occludens-1': [124], '(ZO-1)': [125], 'phosphorylated': [127], 'myosin': [128, 224], 'light': [129, 225], 'chain': [130, 226], 'detected': [132], 'immunohistochemistry.': [134], '<h3>Results:</h3>': [135], 'threefold': [137], 'increase': [138, 219], 'faecal': [140, 177], 'activity': [143, 170, 240], 'seen': [144], 'compared': [148], 'constipation-predominant': [150], 'IBS': [151], '(IBS-C)': [152], 'or': [153], 'diarrhoea': [155], 'neither': [158], 'epithelial': [159, 248], 'nor': [160, 164], 'inflammatory': [161], 'cell': [162], 'origin,': [163], 'coupled': [167], 'antiprotease': [169], 'endogenous': [172], 'origin.': [173], 'Mucosal': [174], 'application': [175], 'mice': [183], 'evoked': [184], 'allodynia': [185, 253], 'increased': [187], '92%,': [190], 'both': [191], 'which': [193], 'effects': [194], 'prevented': [196], 'inhibitors': [200], 'dependent': [202], 'PAR-2': [204], 'expression.': [205], 'In': [206], 'resulted': [215], 'a': [217, 245, 257], 'rapid': [218], 'phosphorylation': [222], 'delayed': [228], 'redistribution': [229], 'ZO-1': [231], 'colonocytes.': [233], '<h3>Conclusions:</h3>': [234], 'Elevated': [235], 'evokes': [244], 'PAR-2-mediated': [246], 'barrier': [249], 'dysfunction': [250], 'subsequent': [252], 'suggesting': [256], 'novel': [258], 'organic': [259], 'background': [260], 'pathogenesis': [263], 'IBS.': [265]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2132122176', 'counts_by_year': [{'year': 2024, 'cited_by_count': 11}, {'year': 2023, 'cited_by_count': 13}, {'year': 2022, 'cited_by_count': 11}, {'year': 2021, 'cited_by_count': 22}, {'year': 2020, 'cited_by_count': 14}, {'year': 2019, 'cited_by_count': 19}, {'year': 2018, 'cited_by_count': 10}, {'year': 2017, 'cited_by_count': 12}, {'year': 2016, 'cited_by_count': 18}, {'year': 2015, 'cited_by_count': 11}, {'year': 2014, 'cited_by_count': 34}, {'year': 2013, 'cited_by_count': 20}, {'year': 2012, 'cited_by_count': 25}], 'updated_date': '2025-01-05T18:33:03.463101', 'created_date': '2016-06-24'}
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