Divergent androgen regulation of unfolded protein response pathways drives prostate cancer

Name: Work Video:
Duration: 3 min 30 s
Xia Sheng; Yke Jildouw Arnoldussen; Margrethe Larsdatter Storm; Martina Tesikova; Hatice Zeynep Nenseth; Sen Zhao; Ladan Fazli; Paul S. Rennie; Bjørn Risberg; Håkon Wæhre; Håvard E. Danielsen; Ian G. Mills; Yang Jin; Gökhan S. Hotamışlıgil; Fahri Saatcioglu
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[997], 'CitationsTrack': [998], 'CitationsPermissions': [999], 'Figures': [1000], '&': [1001, 1369, 1464, 1656, 1777, 1812, 1991, 2942, 3213, 3262], 'Info': [1002], 'Abstract': [1003], '(UPR)': [1008], 'is': [1009, 1021, 1081, 1188, 1194, 1248, 1262, 1311, 1420, 1433, 1532, 1788, 1791, 1824, 1977, 2167, 2311, 3072, 3183, 3199, 3319, 3476, 3489, 3979, 4125], 'homeostatic': [1011], 'mechanism': [1012], 'maintain': [1014], 'endoplasmic': [1015, 1308], 'reticulum': [1016, 1309, 1557], '(ER)': [1017, 1310], 'function.': [1018], 'UPR': [1020, 1055, 1063, 1129, 1163, 1182, 1251, 1395, 1419, 1432, 1605, 1757, 1784, 1831, 1898, 2013, 2033, 2069, 2101, 2120, 2144, 2184, 2197, 2208, 2253, 2266, 2328, 2367, 2402, 2414, 2641, 2854, 2935, 3046, 3068, 3084, 3255, 3353, 3364, 3498, 3510, 3604, 3697, 3715, 3874], 'activated': [1022, 1093, 1426, 2612], 'various': [1024, 1570], 'physiological': [1025, 1338], 'conditions': [1026, 1341, 1574, 1591, 3655], 'as': [1027, 1029, 1034, 1114, 1116, 1298, 1329, 1567, 1593, 1645, 1859, 1918, 2347, 2483, 2939, 3048, 3113, 3258, 3438, 3594, 3911], 'well': [1028, 1115], 'in': [1030, 1072, 1112, 1119, 1124, 1134, 1144, 1175, 1209, 1254, 1264, 1287, 1290, 1325, 1404, 1471, 1478, 1508, 1519, 1549, 1621, 1633, 1637, 1648, 1674, 1709, 1785, 1793, 1833, 1843, 1850, 1900, 1903, 1924, 1967, 1979, 2035, 2055, 2058, 2074, 2082, 2123, 2136, 2189, 2258, 2269, 2283, 2290, 2331, 2372, 2403, 2406, 2417, 2426, 2447, 2463, 2499, 2517, 2539, 2545, 2550, 2619, 2627, 2659, 2692, 2709, 2732, 2736, 2807, 2869, 2893, 2990, 3024, 3053, 3058, 3109, 3175, 3202, 3209, 3229, 3250, 3281, 3290, 3292, 3321, 3324, 3372, 3376, 3379, 3462, 3478, 3557, 3561, 3595, 3618, 3714, 3733, 3775, 3782, 3823, 3835, 3850, 3856, 3869, 3913, 3928, 3971, 3974, 3984, 4007, 4017, 4038, 4059, 4070, 4074, 4077, 4089, 4107, 4130, 4244, 4331, 4359, 4445], 'disease': [1031, 2552], 'states,': [1032], 'such': [1033, 1328, 1566, 1592, 1644, 1858, 1917, 2482, 2938, 3257, 3437], 'cancer.': [1035, 1305], 'As': [1036, 2187, 3279], 'androgens': [1037, 1071, 2029, 2081, 2412, 3002, 3071, 3077, 3146, 3154, 3246, 3337], 'regulate': [1038, 2012, 2049, 2639, 2850, 3861], 'secretion': [1039, 1320], 'development': [1041], 'normal': [1044, 1148, 1269, 2016], 'drive': [1047], '(PCa)': [1050], 'growth,': [1051, 1635], 'they': [1052], 'may': [1053, 1171, 1296, 1731, 2000, 2020, 2062, 2103, 3078, 3155, 3271, 3708, 3992], 'affect': [1054, 2413, 3080, 3993], 'pathways.': [1056, 3499], 'Here,': [1057, 2025], 'we': [1058, 2026, 2098, 2112, 3086, 3216, 3720, 3758, 3987], 'show': [1059, 2027, 3335, 3486, 3842], 'that': [1060, 1159, 1167, 1237, 1293, 1442, 1701, 1765, 1997, 2028, 2092, 2100, 2166, 2250, 2310, 3001, 3065, 3153, 3245, 3314, 3336, 3487, 3706, 3744, 3843, 4033, 4052], 'canonical': [1062, 1469, 2853, 3083, 3497], 'are': [1065, 1231, 1392, 1425, 1443, 1476, 1958, 1962, 2072, 2228, 2256, 2382, 2389, 2824, 2832, 3097, 3239, 3632, 3673, 3677, 3923, 4041, 4067, 4239, 4326, 4405], 'directly': [1066, 3709, 3746, 3845, 3867], 'divergently': [1068, 1160, 2638], 'regulated': [1069, 1963], 'PCa': [1073, 1084, 1109, 1123, 1834, 1845, 1925, 1943, 1956, 1985, 1998, 2036, 2054, 2083, 2132, 2138, 2419, 3210, 3251, 3276, 3325, 3463, 3985, 3994, 4039, 4060, 4071], 'cells,': [1074, 1473, 1643, 1799, 3026, 3252, 3986], 'through': [1075, 4043, 4055], 'receptor': [1078, 1974], '(AR),': [1079, 1975], 'which': [1080, 1315, 1351, 1485, 1548, 1976, 2019, 2872, 3298, 3384, 3742], 'critical': [1082], 'survival.': [1085, 4091], 'AR': [1086, 1127, 1158, 1235, 1246, 2067, 2107, 2118, 2134, 2164, 2193, 2251, 2264, 2305, 3349, 3371, 3380, 3400, 3418, 3449, 3458, 3488, 3502, 3522, 3546, 3582, 3638, 3694, 3707, 3732, 3745, 3763, 3802, 3824, 3844, 3866, 3918, 3977], 'bound': [1087], 'gene': [1089, 1130, 1252, 1544, 1839, 1862, 1891, 2070, 2121, 2125, 2145, 2185, 2198, 2254, 2267, 2279, 2286, 2329, 2415, 3354, 3698], 'regulatory': [1090, 3699, 3712, 3848], 'sites': [1091, 3713, 3788, 3849], 'IRE1α': [1095, 1105, 1169, 1186, 1203, 1215, 1229, 1241, 1274, 1294, 1515, 1727, 2041, 2398, 2421, 2441, 2515, 2557, 2608, 2623, 2707, 2783, 3007, 3054, 3169, 3171, 3182, 3269, 3296, 3341, 3388, 3460, 3794, 3858, 3961, 3990, 3999, 4018, 4037, 4053, 4064, 4082, 4100, 4161, 4264, 4301, 4367], 'branch,': [1096, 2042], 'but': [1097, 1217, 1800, 2043, 2460, 2985, 3160, 3597], 'simultaneously': [1098, 1218, 2927, 3013, 3344], 'inhibited': [1099, 1204], 'PERK': [1100, 1192, 1221, 1517, 1729, 2046, 2864, 2866, 2888, 2913, 3016], 'signaling.': [1101, 2108, 3348], 'Inhibition': [1102, 1272], 'arm': [1106, 1187, 1222, 1230, 3008], 'profoundly': [1107], 'reduced': [1108, 1923, 3228], 'cell': [1110, 1207, 1428, 1805, 2540, 3029, 3277, 3322, 3968, 3995, 4009, 4090, 4115, 4230], 'growth': [1111, 1208, 1286, 1673, 1708, 1747, 2050, 2541, 3969, 4173], 'vitro': [1113, 1210, 1288, 2056, 2404, 3972, 4075], 'tumor': [1117, 1634, 1672, 1707, 1746, 1798, 1889], 'formation': [1118], 'preclinical': [1120, 2519], 'models': [1121, 1676, 1715], 'vivo.': [1125, 2059], 'Consistently,': [1126, 2435, 2606, 2901], 'expression': [1131, 1140, 1247, 1253, 1261, 1545, 1840, 1852, 1892, 1935, 2071, 2122, 2126, 2135, 2146, 2199, 2204, 2255, 2268, 2280, 2287, 2330, 2362, 2416, 2422, 2437, 2469, 2475, 2558, 2581, 2600, 2657, 2708, 2784, 2806, 2948, 2964, 3060, 3123, 3132, 3355, 3389, 3405, 3410, 3422, 3599, 4014], 'were': [1132, 1937, 2156, 2239, 2301, 2335, 2351, 2644, 2666, 2673, 2890, 2958, 3022, 3467, 3515, 3525, 3535, 3606, 3833, 3884, 3903, 4094, 4181, 4200, 4215, 4283, 4291, 4375], 'correlated': [1133, 1249, 2073, 2142, 2195], 'human': [1135, 1255, 2131, 2522, 3110], 'PCa,': [1136, 2523], 'spliced': [1138], 'XBP-1': [1139, 1684, 1702, 2468, 3307, 3963, 4001, 4066, 4084, 4102, 4170, 4266, 4303], 'was': [1141, 1922, 2140, 2281, 2423, 2444, 2456, 2496, 2601, 2610, 2713, 2753, 2789, 2949, 2972, 3124, 3139, 3226, 3286, 3411, 3444, 3567, 3624, 3661, 3909, 4117, 4133, 4305, 4316, 4391], 'significantly': [1142, 2141, 2424, 2445, 2559, 2582, 2891, 2973, 3163, 3227, 3446], 'upregulated': [1143], 'compared': [1146, 1267, 2336, 3166, 3390], 'with': [1147, 1250, 1268, 1343, 1377, 1613, 1629, 1939, 2143, 2196, 2617, 2648, 2675, 2717, 2793, 2812, 3037, 3050, 3241, 3300, 3328, 3394, 3517, 3528, 3537, 3564, 3574, 3621, 3731, 3888, 4096, 4137, 4144, 4183, 4202, 4293], 'prostate.': [1149], 'These': [1150, 2060, 2237, 3150, 3237, 3840, 4045], 'data': [1151, 2061, 2127, 2238, 2288, 2371, 2831, 2999, 3021, 3151, 3238, 3334, 3485, 3676, 3702, 3723, 3792, 3841, 3921, 4049, 4238, 4325], 'establish': [1152], 'genetic': [1154], 'switch': [1155], 'orchestrated': [1156], 'regulates': [1161, 1316], 'suggest': [1166, 3152], 'targeting': [1168, 4098], 'signaling': [1170, 1275, 1295, 1396, 1547, 2102, 3172, 3198, 3318, 3342, 3365, 3461, 3978, 3991], 'have': [1172, 1699, 1847, 2001, 2063, 3272], 'therapeutic': [1173, 1301], 'utility': [1174], 'PCa.': [1176, 1911, 2259], 'Synopsis': [1177], 'Androgens': [1178, 1213, 2395, 2637, 2848], 'generate': [1179], 'divergent': [1181, 3067], 'whereby': [1184], 'activated,': [1189], 'one': [1193, 3926, 4128], 'inhibited.': [1195], 'Genetic': [1196], 'depletion': [1197], 'or': [1198, 1277, 1358, 1493, 1728, 3521, 3880, 3894, 3962, 4000, 4083, 4101, 4207, 4220, 4279, 4371, 4452], 'small': [1199, 1279], 'molecule': [1200, 1280], 'inhibition': [1201, 2910, 2921], 'tumor.': [1212], 'upregulate': [1214], 'signaling,': [1216, 1970, 2047], 'downregulate': [1219], 'UPR.': [1224], 'effects': [1226, 2861, 3219, 3362, 4035], 'on': [1227, 1414, 1827, 2096, 2862, 3220, 3275, 3363, 3657, 3766], 'mediated': [1232, 1434, 4042], 'direct': [1234], 'binding': [1236, 3695, 3803, 3825], 'increases': [1238, 2618, 4057], 'transcription': [1239, 1454, 1537, 3506], 'XBP-1S': [1243, 1260, 2479, 2580, 2625, 3404, 3435, 3811, 4016], 'target': [1244, 1302, 2480, 2936, 2969, 3121, 3136, 3180, 3770, 3812], 'genes.': [1245, 3716, 3753], 'specimens': [1258], 'increased': [1263, 2425, 2446, 2498, 2959, 2989, 3127, 3144, 3310, 3420], 'tissue.': [1271], 'genetically': [1276], 'inhibitors': [1281], 'dramatically': [1282], 'reduces': [1283], 'vivo,': [1291], 'suggesting': [1292, 2249, 3313], 'serve': [1297], 'potential': [1300], 'Introduction': [1306], 'an': [1312, 1373, 1479, 1535, 1630, 2242, 2543, 2569, 3051, 3273, 3980], 'essential': [1313], 'organelle': [1314], 'folding': [1318, 1346, 1402], 'impacts': [1322], 'key': [1323], 'functions': [1324], 'cell,': [1327], 'lipid': [1330], 'biosynthesis,': [1331], 'calcium': [1333], 'homeostasis': [1334], '(Hetz,': [1335], '2012).': [1336, 1993], 'Different': [1337], 'pathological': [1340], 'interfere': [1342], 'capacity': [1347, 1403, 4270], 'ER,': [1350, 2097], 'leads': [1352, 1541, 4085], 'accumulation': [1355, 1490], 'misfolded': [1359, 1494, 2881], 'proteins,': [1360, 1495], 'named': [1361], 'ER': [1362, 1406, 1448, 1450, 1513, 1521, 1554, 1618, 1828, 1855, 2007, 2213, 2877], 'stress': [1363, 1440, 1558, 1619, 1691, 1829, 2878], '(for': [1364, 1575, 1651, 1748, 1807, 1986], 'review,': [1366, 1653, 1750, 1809, 1988], 'see': [1367, 1577, 1654, 1751, 1810, 1989], 'Tabas': [1368], 'Ron,': [1370, 1465], '2011).': [1371, 1466], 'In': [1372, 1467, 1584, 1888, 2453, 2525, 2917, 2962, 3416, 3809], 'attempt': [1374], 'cope': [1376, 1612], 'stress,': [1379], 'several': [1380, 2477, 3749], 'intracellular': [1381], 'signal': [1382], 'transduction': [1383], 'pathways,': [1384], 'collectively': [1385], 'termed': [1386], '(UPR),': [1391], 'activated.': [1393], 'aims': [1397], 'increase': [1399, 2094, 2544, 2570, 3052, 3289, 3822], 'lumen,': [1407], 'thus': [1408, 1995, 2875], 'decreasing': [1409, 2880], 'load': [1413], 'cell.': [1416], 'If': [1417], 'unsuccessful,': [1421], 'however,': [1422], 'apoptotic': [1423, 1804], 'death': [1429, 1688, 1806], 'results.': [1430, 4139], 'at': [1436, 2593, 2613, 2741, 2749, 2762, 2785, 2981, 3098, 3469, 3610, 4393, 4403, 4416, 4424, 4435], 'least': [1437, 2763], 'three': [1438, 2160, 2308, 2333, 2356, 2689, 2764, 2827, 2852, 3670, 4135, 4223, 4329], 'well-conserved': [1439], 'sensors': [1441], 'ER-localized': [1444, 2484], 'transmembrane': [1445, 1500], 'receptors:': [1446], 'pancreatic': [1447], 'kinase-like': [1449], 'kinase': [1451, 1460, 1741], '(PERK),': [1452], 'activating': [1453, 1738, 2039], 'factor': [1455], '6': [1456], '(ATF6),': [1457], 'inositol-requiring': [1459], '1': [1461, 1664, 1863, 1876, 2216], '(IRE1)': [1462], '(Tabas': [1463], 'model,': [1470], 'unstressed': [1472], 'these': [1474, 2998, 3333, 3484, 3756], 'proteins': [1475, 1507, 2937, 3653], 'held': [1477], 'inactive': [1480], 'state': [1481], 'chaperones,': [1484], 'inhibit': [1486, 2045, 3345], 'their': [1487, 3862], 'activity.': [1488], 'Upon': [1489], 'chaperones': [1496], 'dissociate': [1497], 'from': [1498, 1640, 1689, 1927, 2129, 2369, 3331, 3725, 4050, 4447], 'receptors': [1501], 'bind': [1503, 3710], 'lumen': [1510], 'allowing': [1514], 'oligomerization': [1518], 'membrane,': [1522], 'translocation': [1524], 'ATF6α': [1526, 3092, 3120, 3135, 3158], 'Golgi': [1529], 'where': [1530], 'it': [1531, 1790], 'cleaved': [1533], 'into': [1534, 2159, 2307, 4378], 'active': [1536, 1641], 'factor.': [1538], 'This': [1539], 'then': [1540, 2157, 2508, 2857, 3357, 3526, 3904], 'specific': [1543], 'turn': [1550], 'orchestrates': [1551], 'adaptation': [1552], 'stress.': [1555, 1615], 'Endoplasmic': [1556], 'has': [1559, 1667], 'been': [1560, 1668], 'linked': [1561, 2257], 'many': [1563], 'chronic': [1564], 'diseases,': [1565], 'diabetes,': [1568], 'neurodegeneration,': [1569], 'cancers,': [1571], 'proinflammatory': [1573], 'reviews,': [1576], 'Hotamisligil,': [1578], '2010;': [1579, 1775], 'Clarke': [1580, 1752, 1819], 'et': [1581, 1678, 1693, 1717, 1753, 1773, 1816, 1820, 1885, 1930, 1949, 1953, 2554, 3189, 3193, 3739, 3772], 'al,': [1582, 1679, 1694, 1718, 1754, 1774, 1817, 1821, 1886, 1931, 1950, 1954, 2555, 3190, 3194, 3740, 3773], '2014).': [1583, 1755, 1779, 1822], 'cancer,': [1585], 'wide': [1587], 'range': [1588], 'cytotoxic': [1590], 'hypoxia,': [1594], 'pH': [1595], 'changes,': [1596], 'nutrient': [1598], 'deprivation': [1599], 'trigger': [1600], 'activation': [1602, 1724, 2867, 3105, 3225, 3249], 'help': [1607], 'cells': [1610, 1686, 1769, 1787, 1835, 1846, 1957, 1999, 2037, 2629, 2643, 2661, 2721, 2809, 2895, 3035, 3178, 3211, 3294, 3374, 3392, 3514, 3562, 3587, 3619, 3643, 3737, 3784, 3837, 3882, 3902, 4020, 4029, 4040, 4072, 4093, 4180, 4199, 4214, 4282, 4363], 'Thus,': [1616, 1780], 'setting': [1623], 'could': [1624], 'be': [1625, 2104], 'cytoprotective': [1627], 'important': [1631, 1978], 'role': [1632, 1782, 2079], 'especially': [1636], 'tumors': [1638, 2139, 2155, 2533, 2766, 4358, 4402, 4446], 'arising': [1639], 'secretory': [1642, 1960, 2087], 'case': [1647], 'multiple': [1649], 'myeloma': [1650], 'Tsai': [1655], 'Weissman,': [1657], '2010).': [1658, 1719], 'For': [1659], 'example,': [1660], 'IRE1α-X-box-binding': [1662], '(XBP-1)': [1665], 'pathway': [1666, 2609, 2914, 3108, 3859, 3983], 'shown': [1669, 1700, 1848, 2188, 3114, 3280, 3477, 3633, 3922], 'promote': [1671], 'xenograft': [1675], '(Romero-Ramirez': [1677], '2004)': [1680], 'loss': [1682, 3964], 'sensitized': [1685], 'oxidative': [1690], '(Liu': [1692], '2009).': [1695], 'Transgenic': [1696], 'mice': [1697, 2738, 4384, 4386], 'studies': [1698], 'splicing': [1703], 'occurs': [1704], 'during': [1705], 'primary': [1706], 'number': [1711], 'breast': [1713], '(Spiotto': [1716], 'However,': [1720, 3112], 'under': [1721, 3654], 'certain': [1722], 'conditions,': [1723], 'lead': [1732], 'apoptosis,': [1734, 2546], 'example': [1736], 'c-Jun': [1739, 3184], 'N-terminal': [1740, 3185], '(JNK),': [1742], 'thereby': [1744], 'inhibiting': [1745, 3014], 'Furthermore,': [1756, 2473], 'can': [1758, 1766, 1802], 'impact': [1759], 'autophagy': [1760], 'mitophagy,': [1762], 'two': [1763, 4242], 'processes': [1764], 'impart': [1767], 'survival': [1770, 1947, 2052], 'benefit': [1771], '(Kroemer': [1772], 'Maes': [1776], 'Agostinis,': [1778], 'paradoxical:': [1789], 'involved': [1792, 3201, 3320, 3855], 'adaptive': [1795, 2008, 3006], 'also': [1801, 2021, 2611, 3079, 3309, 3445], 'initiate': [1803], 'Liu': [1811], 'Ye,': [1813], '2011;': [1814], 'Vandewynckel': [1815], '2013;': [1818], 'There': [1823, 2350], 'limited': [1825, 3100], 'information': [1826], 'date.': [1837], 'Global': [1838], 'profiling': [1841, 1893], 'experiments': [1842, 2691, 3672, 3730, 4243, 4330], 'androgen-treated': [1844], 'changes': [1849], 'some': [1854, 1914, 2365], 'stress-associated': [1856], 'genes,': [1857, 2209, 2481], 'N-myc': [1860], 'downstream-regulated': [1861], '(NDRG1),': [1865], 'disulfide': [1867], 'isomerase-related': [1868], '(PDIR),': [1870], 'homocysteine-responsive': [1871], 'ER-resident': [1872], 'ubiquitin-like': [1873], 'domain': [1874], 'member': [1875], '(HERPUD1),': [1878], 'oxygen-regulated': [1880], '150': [1882], '(ORP150)': [1883], '(Segawa': [1884, 1929], '2002).': [1887, 3195], 'models,': [1890], 'indicated': [1894, 2652, 2664, 2743, 2816, 3532, 3603, 3611, 3652, 3656, 3705, 4187, 4395], 'downregulation': [1895, 3057], 'branches': [1899], 'high-grade': [1901], 'PIN': [1902], 'Nkx3.1:Pten': [1904], 'mutant': [1905], 'mice,': [1906], 'mouse': [1908], 'model': [1909, 2520], 'Expression': [1912, 3432, 3543, 3560, 3617, 3649], 'ER-associated': [1915], 'molecules,': [1916], 'HERPUD1': [1919], 'NDRG1,': [1921], 'samples': [1926], 'patients': [1928], '2002),': [1932], 'GRP78': [1934], 'levels': [1936, 2194, 2326, 2465, 2574, 2592, 2626, 2658, 2889, 2903, 2957, 2988, 3381, 3428, 3600], 'associated': [1938], 'greater': [1940], 'risk': [1941], 'recurrence': [1944], 'worse': [1946], '(Pootrakul': [1948], '2006;': [1951], 'Daneshmand': [1952], '2007).': [1955], 'highly': [1959], 'hormonal': [1965], 'signals,': [1966], 'particular': [1968], 'via': [1971], 'initiation': [1981], 'progression': [1983, 2084], 'Bluemn': [1990], 'Nelson,': [1992], 'We': [1994, 2408, 2507, 2856, 3265, 3356], 'postulated': [1996], 'developed': [2002], 'ways': [2003], 'engage': [2005], 'hormonally': [2011], 'sustain': [2015], 'tissue': [2017], 'integrity': [2018], 'support': [2022, 4047], 'tumorigenesis.': [2024], 'induce': [2030], 'unique': [2032], 'profile': [2034], 'coordinately': [2044], 'translational': [2064], 'implications.': [2065], 'Results': [2066], 'Given': [2077], 'function': [2088], 'would': [2093], 'burden': [2095], 'hypothesized': [2099], 'affected': [2105, 2603, 2951, 3413], 'To': [2109, 3074, 3717, 3754], 'assess': [2110, 3718], 'this,': [2111, 3019, 3719], 'investigated': [2113, 2667, 3087, 3358], 'possible': [2115, 2510, 2859], 'concordance': [2116], 'between': [2117, 2275, 2354, 2700, 2777, 3581, 3637, 3948, 4156], 'set': [2128, 2681, 2754, 3568, 3625, 3724], '190': [2130], 'tumors.': [2133, 4454], '(Supplementary': [2147, 2200, 2246, 2358, 2470, 2504, 2952, 2978, 3031, 3061, 3116, 3147, 3234, 3304, 3429, 3451], 'Fig': [2148, 2190, 2471, 2505, 2953, 2979, 3032, 3062, 3117, 3148, 3235, 3283, 3305, 3430, 3452, 3480], 'S1': [2149], 'Supplementary': [2151, 3282, 3479], 'Table': [2152, 2201, 2247, 2359], 'S1).': [2153], 'stratified': [2158, 2192, 2302], 'groups': [2161, 2334, 2357], 'according': [2162, 2303], 'status,': [2165], 'ARLow': [2168], '(n': [2169, 2173, 2178, 2296, 2313, 2317, 2322], '=': [2170, 2174, 2179, 2297, 2314, 2318, 2323, 2715, 2751, 2797, 3576, 4146, 4251, 4254, 4338, 4344, 4412, 4420, 4428], '60),': [2171, 2180, 2315], 'ARmedium': [2172, 2316], '70),': [2175, 2319], 'ARhigh': [2177, 2321], 'assessed': [2182, 2282, 2410, 2858, 3554], 'expression.': [2186, 3863], '1A,': [2191], 'S2).': [2202, 2360], 'profiles': [2205, 2363], 'prominent': [2207, 2366], 'ERN1': [2211, 2375], '(IRE1),': [2212, 2376], 'degradation-enhancing': [2214], 'alpha-mannosidase-like': [2215], '(EDEM1),': [2217], 'ATF6': [2218], 'DNAJC3': [2220, 2380], '(or': [2221], '58': [2222], 'kDa': [2223], 'interferon-induced': [2224], 'kinase,': [2226], 'P58IPK),': [2227], 'presented': [2229, 2346, 2823, 3703], 'separately': [2230], 'ease': [2232], 'evaluation': [2234], '(Fig': [2235, 2433, 2451, 2578, 2596, 2604, 2633, 2899, 2915, 2960, 2995, 3382, 3397, 3406, 3414, 3423, 3473, 3785, 3807, 3829, 3838, 4011, 4030], '1B).': [2236], 'validated': [2240], 'using': [2241, 2337, 2668, 2722, 2799, 3588, 3644, 3917, 3953, 4119, 4165, 4189, 4233, 4258, 4318, 4348, 4438], 'independent': [2243, 2690, 2765, 2828, 3671], 'patient': [2244], 'cohort': [2245, 2295], 'S3),': [2248], 'Figure': [2260, 2635, 2841, 3500, 3686, 3864, 4062], '1.': [2261, 2756, 3570], 'Correlation': [2262], 'cohorts': [2272], 'Possible': [2273], 'correlation': [2274, 2339], 'AR-': [2276], 'UPR-associated': [2278, 3752], 'global': [2285], 'available': [2289, 2833, 3096, 3678], 'TCGA': [2292], 'Adenocarcinoma': [2294], '190)': [2298], '(http://www.cbioportal.org/public-portal/index.do).': [2299], 'Tumors': [2300], 'status': [2306], 'groups,': [2309], 'ARlow': [2312], '60).': [2324], "Pearson's": [2338], 'analysis': [2340, 4219, 4354], 'R': [2343], 'software': [2344, 4322], 'heatmap.': [2349], 'significant': [2352, 2461, 3288, 3579, 3635, 3946, 4005], 'differences': [2353], 'genes': [2368, 2388, 2665, 3605, 3813, 3854, 3875], '(A),': [2373, 3596], 'EDEM1,': [2377, 2495, 3440], 'ATF6,': [2378], '(P58IPK),': [2381], 'presented.': [2383], 'P-values': [2384, 2698, 2775, 3631], 'different': [2387, 3509, 3873], 'given.': [2390], 'Download': [2391, 2393, 2844, 2846, 3689, 3691, 3957, 3959], 'figure': [2392, 2845, 3690, 3958], 'PowerPoint': [2394, 2847, 3692, 3960], 'activate': [2396, 3004, 3156, 3338], 'branch': [2399, 2516], 'vivo': [2407, 3975, 4078], 'next': [2409, 3266], 'whether': [2411, 3076, 3268, 3359, 3989], 'LNCaP': [2418, 2628, 2660, 2808, 2894, 3034, 3293, 3373, 3513, 3558, 3734, 3783, 3878, 3938, 4008, 4092, 4177, 4179, 4272, 4357, 4362], 'cells.': [2420, 3111, 3326, 3464, 3559, 4061, 4178, 4273], 'time-dependent': [2428], 'manner': [2429, 2450], 'upon': [2430, 2561, 2630, 2810, 2896, 2906, 2975, 3128, 3295, 3448, 3548, 3779, 3804, 3826], 'administration': [2432], '2A).': [2434], 'principal': [2440], 'target,': [2442], 'XBP-1S,': [2443, 2728, 4056], 'similar': [2449, 2547, 3020, 3045, 4138], '2B).': [2452], 'contrast,': [2454, 3417], 'there': [2455, 3285], 'very': [2458], 'marginal,': [2459], 'change': [2462], 'unspliced': [2467], 'S2A).': [2472], 'established': [2478, 3981], 'DnaJ': [2485], '4': [2486, 2492], '(ERdj4),': [2487], 'P58IPK,': [2488, 3439], 'ribosome-associated': [2489], 'membrane': [2490], '(RAMP4),': [2493], 'robustly': [2497], 'treatment': [2503, 2632, 2811, 2898, 2977, 2994, 3550, 3781, 3806, 3828], 'S2B–E).': [2506], 'studied': [2509], 'CWR22.': [2524], 'withdrawal': [2529], 'castration,': [2531], 'CWR22': [2532, 2733], 'regress': [2534], 'due': [2535], 'decrease': [2538, 4006, 4088], 'situ': [2551], '(Wainstein': [2553], '1994).': [2556], 'decreased': [2560, 2583, 2892, 2905, 2974, 3447], 'castration': [2562], 'up': [2563], '72': [2565, 2585], 'h': [2566, 2577, 2586, 2595, 2679, 2712, 2787, 3553, 3893], 'followed': [2567], 'back': [2571, 4023], 'basal': [2573, 2591], '120': [2576, 2594], '2C).': [2579], 'after': [2584, 2745, 3614, 4195, 4212], 'reaching': [2587], 'approximately': [2588, 3796], '40%': [2589], '2D),': [2597], 'whereas': [2598, 3205, 3408], 'XBP-1U': [2599, 2730, 3122, 3409], 'not': [2602, 2950, 3412], '2E).': [2605], 'level': [2616, 3472, 3544, 4026], 'phosphorylated': [2620, 2887], 'IRE1α,': [2621, 2727], 'total': [2622, 2885], '2F).': [2634, 2961], '2.': [2636], 'armsLNCaP': [2642], 'cultured': [2645, 3885, 4221, 4284], 'treated': [2647, 2674, 3036, 3393, 3527, 3536, 3887], 'R1881': [2649, 2710, 2813, 3049, 3529, 3615, 3895, 3952], 'times.': [2653, 3533], 'A,': [2654, 3876], 'B.': [2655, 3877, 4169], 'mRNA': [2656, 2731, 2947, 2983, 3547, 3598], 'quantitative': [2669], 'PCR': [2670], '(qPCR).': [2671], 'Controls': [2672, 3534], 'vehicle': [2676, 3538, 3889], '84': [2678], '100.': [2683, 3627], 'represent': [2685, 2696, 2758, 2773, 3572, 3629, 3932, 4142, 4248, 4335], 'mean': [2687, 2760], 'triplicate,': [2693], 'bars': [2695, 2772, 3931, 4141, 4247, 4334, 4408], 'SE.': [2697, 2774, 3630, 3933, 4249], 'ranged': [2699, 2776], '1.66': [2701], '×': [2702, 2779, 2791, 4148, 4152, 4256, 4340, 4346], '10−5': [2703, 4149, 4153], '0.025,': [2705], '48': [2711, 2786, 3540, 3552, 3892, 3899], '*P': [2714, 3575, 3934, 3940, 4145, 4250, 4337, 4411], '0.013': [2716], 'respect': [2718, 2794], 'vehicle-treated': [2720], 'unpaired': [2723, 2800, 3645, 3954, 4439], "Student's": [2724, 2801, 3590, 3646, 3955, 4167, 4260, 4350, 4440], 't-test.': [2725, 2802, 3591, 3647, 3956, 4168, 4261, 4351, 4441], 'C–E.': [2726], 'xenografts': [2734], 'grown': [2735], 'nude': [2737, 4360, 4383], 'collected': [2740], 'times': [2744, 2817, 4136], 'castration.': [2746], 'value': [2748], 't': [2750, 2796], '0': [2752, 2798], 'Columns': [2757], 'each': [2768], 'time': [2769, 3612, 4396], 'point,': [2770], '5.7': [2778], '10−10': [2780], '0.0002.': [2782], 'post-castration': [2788], '3.17': [2790], '10−6': [2792], 'F,': [2803], 'G.': [2804], 'Protein': [2805], 'Western': [2819, 3664, 4218, 4308], 'blot': [2820, 3665, 4309], 'analysis.': [2821, 3666, 4310], 'representative': [2825, 3924, 4126, 4240, 4327], 'experiments.': [2829, 3762], 'online': [2834, 3679], 'figure.': [2837, 3682], '2': [2842], '[emmm201404509-sup-0005-SDataFig2.pptx]': [2843], 'differentially': [2849, 3351, 3504], 'pathway.': [2865], 'results': [2868, 3330, 3466, 3832], 'eIF2α': [2870, 2925], 'phosphorylation': [2871, 2926], 'inhibits': [2873, 3173, 3965, 4268], 'translation,': [2874], 'alleviating': [2876], 'overload.': [2883], 'Both': [2884], '2G).': [2900, 2916, 2996], 'p-eIF2α': [2902, 3059], 'rapidly': [2904], 'exposure': [2908], 'confirming': [2909, 3064], 'addition': [2918], 'general': [2920], 'synthesis,': [2924], 'promotes': [2928], 'translation': [2930], 'subset': [2933], 'ATF4': [2940, 2946, 2955, 3427], '(Holcik': [2941], 'Sonenberg,': [2943], '2005).': [2944], 'Whereas': [2945], 'S3A),': [2954], 'addition,': [2963, 3810], 'CHOP,': [2966], 'downstream': [2968], 'ATF4,': [2971], 'S3B)': [2980], 'level,': [2984], 'its': [2986, 3768], 'Altogether,': [2997], 'indicate': [3000, 3945, 4409], 'selectively': [3003], 'UPR,': [3011], 'while': [3012], 'branch.': [3017, 3093], 'Supporting': [3018], 'obtained': [3023, 3468, 3834], 'VCaP': [3025, 3736, 3836, 3881, 3944], 'another': [3027, 3134], 'androgen-responsive': [3028], 'line': [3030], 'S4A).': [3033], 'natural': [3039], 'dihydrotestosterone': [3041], '(DHT)': [3042], 'induced': [3043], 'S4B),': [3063], 'physiological.': [3073], 'determine': [3075], 'third': [3082], 'pathway,': [3085, 3159, 4054], 'targets': [3089], 'reagents': [3095], 'present': [3099], 'assay': [3102, 3908, 4232], 'above': [3115, 3704, 4051], 'S2A),': [3118], 'only': [3125, 3140], 'slightly': [3126], 'treatment.': [3130], 'Similarly,': [3131, 3399], 'gene,': [3137], 'GRP78,': [3138], 'modestly': [3141], '(approximately': [3142], '2-fold)': [3143], 'S3C).': [3149], 'lesser': [3164], 'degree': [3165], 'arm.': [3170], 'apoptosis': [3174, 3208, 3291], 'One': [3179, 4193], 'Kinase': [3186], '(JNK)': [3187], '(Urano': [3188], '2000;': [3191], 'Nishitoh': [3192], 'Since': [3196, 3976], 'IRE1α-XBP-1S': [3197], 'generally': [3200], 'proliferative': [3203, 3340, 3982, 4068], 'effects,': [3204], 'JNK': [3206, 3221, 3224, 3248, 3347], 'induces': [3207], '(Lorenzo': [3212], 'Saatcioglu,': [3214, 3263], '2008),': [3215], 'determined': [3217, 3267, 3607, 3662, 4306], 'activation.': [3222], 'UV-induced': [3223], 'stimulation': [3233], 'S4C).': [3236], 'consistent': [3240], 'previous': [3242], 'findings': [3243, 4046], 'showing': [3244, 4032], 'block': [3247], 'triggered': [3253], 'inducers,': [3256], 'thapsigargin': [3259], '(e.g.,': [3260], 'Lorenzo': [3261], '2008).': [3264], 'knockdown': [3270, 3297, 3308, 3350, 3369, 3401, 3419, 3450, 3503, 4019, 4267, 4304], 'effect': [3274], 'viability.': [3278], 'S5A,': [3284], 'coincided': [3299], 'cleavage': [3301], 'caspase-3': [3303, 3311], 'S5B).': [3306], 'cleavage,': [3312], 'whole': [3316], 'IRE1α-XBP-1': [3317], 'viability': [3323, 4116], 'Together': [3327], 'above,': [3332], 'proapoptotic': [3346], 'affects': [3352], 'require': [3366], 'AR.': [3367], 'siRNA-mediated': [3368], 'resulted': [3375], '60–70%': [3377], 'reduction': [3378], '3A),': [3383], 'completely': [3385], 'blocked': [3386], 'R1881-induced': [3387], 'control': [3395, 3518, 3585, 3641, 4028, 4205, 4372], 'siRNA': [3396, 3520, 3549, 3566, 3623, 4097, 4159, 4188, 4196], '3B).': [3398], 'prevented': [3402], 'androgen-induced': [3403], '3C),': [3407], '3E).': [3415], 'CHOP': [3421], '3D)': [3424], 'without': [3425], 'affecting': [3426], 'S6E).': [3431], 'other': [3434], 'targets,': [3436], 'RAMP4,': [3441], 'ERdj4,': [3443], 'S6A–D)': [3453], 'underscoring': [3454], 'importance': [3456], 'Similar': [3465, 3831], '3F,': [3474], 'quantification': [3475], 'S6F).': [3481], 'Taken': [3482], 'together,': [3483], 'required': [3490], 'selective': [3492], '3.': [3501], 'influences': [3505], 'membersAfter': [3511], 'starvation,': [3512], 'transfected': [3516, 3563, 3620, 4095, 4182, 4201], '(CTRL)': [3519], 'siRNA.': [3523], 'Cells': [3524], 'h.': [3541, 3900], 'A.': [3542, 4079], 'qPCR': [3556, 3609], 'CTRL': [3565, 3622], 'Bars': [3571, 3628], 'SE': [3573], '0.001': [3577], 'indicating': [3578, 3634], 'difference': [3580, 3636, 3947], 'siRNA-': [3583, 3639], 'siRNA-transfected': [3586, 3642], 'paired': [3589, 4166, 4259, 4349], 'B–E.': [3592], 'Same': [3593], 'points': [3613], 'stimulation.': [3616], 'F.': [3648, 4442], 'top': [3659], 'label': [3660], 'Representative': [3667, 4398], 'blots': [3668], 'shown.': [3674, 4406], '3': [3687, 4112, 4286], '[emmm201404509-sup-0006-SDataFig3.pptx]': [3688], 'Direct': [3693], 'sequences': [3700], 'examined': [3721], 'chromatin': [3726], 'immunoprecipitation': [3727], 'sequencing': [3728], '(ChIP-seq)': [3729], '(Massie': [3738], '2011)': [3741], 'suggested': [3743], 'binds': [3747, 3846, 3868], 'validate': [3755], 'observations,': [3757], 'performed': [3759, 3910], 'individual': [3760], 'ChIP': [3761, 3907], 'efficiently': [3764], 'loaded': [3765], 'classical': [3769], '(Brookes': [3771], '1998)': [3774], 'PSA': [3777], 'enhancer': [3778], '4A).': [3786, 3808, 3830], 'Two': [3787], 'predicted': [3789], 'ChIP-Seq': [3791], 'showed': [3795], '6-': [3797], '8-fold': [3799], 'enrichment': [3800], 'RAMP4': [3814], 'EDEM1': [3816], 'had': [3817], '2.5-': [3819], '4-fold': [3821], '4B).': [3839], 'vicinity': [3852, 3871], '4.': [3865], '(A)': [3879], '(B)': [3883], '(C)': [3890], '24': [3897], 'fixed,': [3905], 'described': [3912], 'Materials': [3914], 'Methods': [3916], 'antibody.': [3919], 'experiment': [3927, 4129], 'duplicate.': [3929], 'Error': [3930, 4140, 4246, 4333, 4407], '<': [3935, 3941], '0.01': [3936, 4429], '0.04': [3942], 'C': [3949], '(control)': [3950], 'both': [3970, 4073, 4379, 4431], 'explored': [3988], 'growth.': [3996], 'Knockdown': [3997, 4080], 'led': [4002], 'proliferation': [4010, 4022, 4058, 4231], '5A).': [4012], 'Ectopic': [4013], 'restored': [4021], '5B)': [4031], 'XBP-1S.': [4044], '5.': [4063], 'factors': [4069], 'either': [4099, 4203], '(5': [4103], 'nM)': [4104], 'starved': [4106], '2%': [4108], 'CT-FCS': [4109], 'medium': [4110], 'days': [4113, 4211, 4225], 'before': [4114, 4226], 'measured': [4118, 4392], 'CCK-8': [4121, 4235], 'assay.': [4122], 'graph': [4124], 'triplicate': [4131], 'repeated': [4134], 'SD': [4143], '6.6': [4147], '4.5': [4151], 'comparison': [4155], 'Ctrl': [4157], 'against': [4160, 4366], 'XBP-1,': [4163], 'respectively,': [4164], 'rescues': [4171], 'defect': [4174], 'siIRE1α-transfected': [4176], '5': [4184], 'nM': [4185], 'Lipofectamine': [4190], 'RNAiMax': [4191], 'reagent.': [4192, 4236], 'day': [4194], 'transfection,': [4197, 4213], 'vector': [4204], '(Empty)': [4206], 'Flag-XBP-1S': [4208], '(XBP-1S).': [4209], 'Three': [4210], 'harvested': [4216], 'being': [4227], 'applied': [4228], 'triplicate.': [4245, 4332], '0.02,': [4252], '**P': [4253, 4343, 4427], '8.54': [4255], '10−7': [4257, 4341], 'C,': [4262], 'D.': [4263], 'clonogenic': [4269], 'Control': [4274], 'LN-Scr': [4275, 4453], '(Scr),': [4276], 'LN-shIRE1': [4277], '(shIRE1),': [4278], 'LN-shXBP1': [4280], '(shXBP-1)': [4281], 'weeks.': [4287], 'colonies': [4289, 4315], 'formed': [4290], 'stained': [4292], 'crystal': [4294], 'violet': [4295], 'photographed.': [4297], 'extent': [4299], 'area': [4312], 'covered': [4313], 'quantified': [4317], 'Gene': [4320], 'Tools': [4321], '(SynGene).': [4323], 'SEM.': [4336, 4410], '4.38': [4339], '3.39': [4345], '10−20': [4347], 'E.': [4352], 'Growth': [4353], 'xenografted': [4356], 'mice.': [4361], 'expressing': [4364], 'shRNA': [4365, 4373], '(LN-shIRE1),': [4368], 'XBP1': [4369], '(LN-shXBP-1),': [4370], '(LN-Scr)': [4374], 'subcutaneously': [4376], 'implanted': [4377], 'flanks': [4380], 'male': [4382], '(6': [4385], 'per': [4387], 'group).': [4388], 'Tumor': [4389], 'size': [4390], 'points.': [4397], 'pictures': [4399], 'harvest': [4404], '0.03': [4413], 'shIRE1': [4415, 4432], 'week': [4417, 4425, 4436], '7,': [4418, 4426], 'P': [4419], '0.02': [4421], 'shXBP-1': [4423, 4434], '8': [4437], 'PCNA': [4443], 'immunostaining': [4444], 'animals': [4448], 'bearing': [4449], 'LN-shIRE1,': [4450], 'LN-shXBP-1,': [4451], 'Sca': [4455]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2132092508', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 17}, {'year': 2022, 'cited_by_count': 17}, {'year': 2021, 'cited_by_count': 11}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 7}, {'year': 2017, 'cited_by_count': 7}, {'year': 2016, 'cited_by_count': 9}, {'year': 2015, 'cited_by_count': 2}], 'updated_date': '2024-12-10T10:40:44.452299', 'created_date': '2016-06-24'}
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