Publication Information

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'abstract_inverted_index': {'Mitochondria': [0, 176], 'are': [1, 177, 493, 926, 1084, 3791, 3887, 4036, 4359, 4388], 'the': [2, 12, 31, 36, 52, 62, 92, 117, 147, 161, 178, 188, 207, 212, 228, 238, 268, 293, 323, 337, 471, 552, 558, 708, 929, 985, 988, 1033, 1036, 1047, 1101, 1151, 1158, 1163, 1169, 1179, 1184, 1211, 1243, 1249, 1273, 1284, 1291, 1306, 1320, 1357, 1359, 1363, 1369, 1420, 1434, 1440, 1461, 1481, 1494, 1572, 1578, 1593, 1620, 1639, 1654, 1688, 1749, 1771, 1798, 1811, 1827, 1856, 1866, 1890, 1933, 1955, 1959, 2053, 2106, 2197, 2217, 2231, 2300, 2305, 2367, 2454, 2493, 2499, 2586, 2620, 2648, 2696, 2724, 2765, 2830, 2947, 3117, 3315, 3344, 3368, 3373, 3398, 3455, 3459, 3505, 3559, 3598, 3610, 3657, 3669, 3680, 3686, 3711, 3716, 3723, 3803, 3857, 3900, 3916, 3935, 3957, 4048, 4111, 4124, 4134, 4157, 4197, 4214, 4232], 'major': [3, 157, 179, 333, 472, 1307, 1431, 1673, 3819, 4174], 'organelles': [4, 180], 'that': [5, 78, 85, 153, 181, 254, 261, 329, 636, 797, 838, 875, 924, 1027, 1083, 1668, 3656, 3703, 3774, 3794, 3875, 4043, 4067, 4140, 4224], 'produce': [6, 182, 2734], 'reactive': [7, 183, 387, 420], 'oxygen': [8, 184, 388, 421], 'species': [9, 185, 389, 422], '(ROS)': [10, 186], 'and': [11, 47, 66, 84, 99, 163, 187, 223, 242, 260, 275, 339, 357, 419, 444, 518, 589, 598, 700, 874, 955, 997, 1035, 1055, 1142, 1148, 1181, 1213, 1397, 1466, 1483, 1496, 1529, 1584, 1608, 1628, 1762, 1877, 1912, 1951, 1981, 2009, 2029, 2076, 2102, 2203, 2226, 2269, 2320, 2362, 2422, 2476, 2492, 2574, 2581, 2637, 2711, 2748, 2841, 2883, 2942, 3021, 3063, 3104, 3131, 3137, 3154, 3159, 3171, 3253, 3311, 3365, 3442, 3469, 3572, 3628, 3668, 3699, 3706, 3760, 3811, 3830, 3833, 3848, 3863, 3884, 3907, 3939, 3941, 3945, 4003, 4018, 4025, 4038, 4054, 4059, 4092, 4114, 4137, 4172, 4185, 4210, 4220, 4356, 4385], 'main': [13, 189], 'target': [14, 190], 'of': [15, 27, 33, 54, 88, 112, 125, 136, 144, 191, 203, 209, 230, 264, 288, 301, 312, 320, 353, 368, 440, 470, 474, 566, 803, 847, 932, 987, 1044, 1049, 1076, 1103, 1153, 1166, 1208, 1275, 1286, 1293, 1309, 1371, 1383, 1407, 1437, 1464, 1471, 1478, 1499, 1575, 1596, 1605, 1611, 1616, 1626, 1650, 1675, 1737, 1752, 1802, 1892, 1938, 2196, 2219, 2224, 2233, 2294, 2302, 2307, 2310, 2464, 2468, 2507, 2536, 2542, 2550, 2622, 2627, 2650, 2652, 2723, 2773, 2802, 2844, 2897, 2946, 2949, 2954, 3005, 3031, 3166, 3236, 3262, 3271, 3285, 3317, 3321, 3337, 3346, 3370, 3387, 3435, 3439, 3445, 3467, 3472, 3498, 3603, 3609, 3673, 3694, 3704, 3715, 3775, 3795, 3806, 3843, 3856, 3868, 3896, 3902, 3918, 3934, 3956, 3972, 4030, 4044, 4068, 4100, 4127, 4145, 4159, 4169, 4217, 4226, 4234, 4396], 'ROS-induced': [16, 120, 192, 296, 1581], 'damage': [17, 102, 129, 193, 278, 305, 362, 414, 501, 1583, 4078], 'as': [18, 194, 694, 993, 995, 1278, 1305, 1723, 2082, 2108, 2299, 2533, 2849, 3367, 3454, 3457, 3534, 3685, 4095, 4178], 'observed': [19, 195, 3826], 'in': [20, 35, 60, 75, 107, 146, 160, 169, 196, 211, 236, 251, 283, 322, 336, 345, 427, 523, 885, 928, 1046, 1073, 1100, 1132, 1168, 1178, 1242, 1356, 1433, 1439, 1480, 1577, 1790, 1889, 1898, 1919, 1988, 2178, 2419, 2504, 2557, 2900, 2956, 3015, 3076, 3080, 3094, 3122, 3233, 3292, 3314, 3421, 3786, 3808, 3827, 3835, 3846, 3853, 3876, 3905, 3978, 4076, 4103, 4106, 4110, 4129, 4156, 4192, 4207, 4213, 4238, 4243, 4361, 4390], 'various': [21, 197, 595, 690, 1062, 1609, 2462], 'pathological': [22, 198], 'states': [23, 199], 'including': [24, 200, 431, 1052, 3882], 'aging.': [25, 201], 'Production': [26, 202], 'NADPH': [28, 158, 204, 334, 1277, 1311, 1365, 1479, 2270, 3339, 3371], 'required': [29, 205, 1149], 'for': [30, 40, 142, 206, 216, 318, 990, 1150, 1266, 1283, 1361, 1502, 1599, 1687, 2087, 2200, 2313, 2359, 2458, 2478, 2552, 2688, 2717, 2756, 2893, 2939, 2992, 3026, 3053, 3068, 3085, 3098, 3225, 3250, 3474, 3492, 3507, 3541, 3597, 3778, 3924, 4354, 4383], 'regeneration': [32, 143, 208, 319, 1285], 'glutathione': [34, 45, 145, 210, 221, 321, 1126, 1137, 1155, 1239, 1295, 2318, 2322, 3446, 4180, 4183], 'mitochondria': [37, 162, 213, 338, 492, 709, 1102, 1185, 1214, 1244, 1482], 'is': [38, 80, 155, 214, 256, 331, 380, 564, 705, 1098, 1173, 1354, 1671, 2297], 'critical': [39, 215], 'scavenging': [41, 217], 'mitochondrial': [42, 55, 63, 101, 218, 231, 239, 277, 354, 364, 394, 398, 502, 524, 559, 567, 637, 798, 848, 890, 979, 1028, 1080, 1125, 1154, 1276, 1294, 1364, 1372, 1389, 1393, 1635, 1676, 1683, 1991, 2221, 2317, 2321, 3687, 3712, 3754, 4170, 4179, 4182, 4252, 4262, 4272, 4282, 4292], 'ROS': [43, 83, 93, 219, 259, 269, 475, 499, 555, 638, 799, 849, 891, 925, 1029, 1045, 1627, 2760], 'through': [44, 220, 1205, 1871], 'reductase': [46, 222, 3447], 'peroxidase': [48, 224, 1127, 2323], 'systems.': [49, 225], 'We': [50, 73, 226, 249, 1490], 'investigated': [51, 227, 1571], 'role': [53, 124, 168, 229, 300, 344, 884, 1043, 1131, 1432, 1574, 3917], 'NADP+-dependent': [56, 232, 365, 399, 403, 1394, 1399], 'isocitrate': [57, 233, 366, 392, 396, 400, 404, 1384, 1438, 1472], 'dehydrogenase': [58, 234, 391, 393, 397, 401, 405, 1300, 1353, 1385, 2361, 4209], '(IDPm)': [59, 235, 1396], 'controlling': [61, 237], 'redox': [64, 240, 355, 1373], 'balance': [65, 241, 356], 'subsequent': [67, 243, 2103], 'cellular': [68, 170, 244, 346, 358, 1050, 1310, 1315], 'defense': [69, 171, 245, 347, 359, 1160, 1579, 1689], 'against': [70, 127, 172, 246, 303, 348, 360, 1162, 1580, 1690], 'oxidative': [71, 128, 173, 247, 304, 349, 361, 417, 497, 1316, 1435, 1582, 1612, 1692, 3890], 'damage.': [72, 121, 248, 297, 498, 1662], 'demonstrate': [74, 250, 4073], 'this': [76, 252, 1568, 4107], 'report': [77, 253, 794], 'IDPm': [79, 89, 113, 126, 154, 255, 265, 289, 302, 330, 1465, 1504, 1576, 1601, 1617, 1651, 1670, 1695, 1729, 1743, 1772, 1806, 1818, 1927, 1940, 2080, 2227, 2295, 3509, 3543, 3579, 3604, 3630, 3660, 3696, 3718, 3727, 3798, 3807, 3820, 3844, 3869, 3897, 3903, 3919, 3927, 3937, 3943, 3959, 3973, 3993, 4009, 4031, 4062, 4104, 4128, 4146, 4152, 4227], 'induced': [81, 257, 415, 593], 'by': [82, 258, 363, 416, 594, 688, 1002, 1089, 1146, 1290, 1318, 1591, 1603, 1618, 1632, 1766, 1810, 1855, 1869, 1958, 1968, 2023, 2063, 2188, 2230, 2326, 2366, 2431, 2490, 2498, 2585, 2589, 2647, 2764, 2885, 2944, 2961, 3190, 3230, 3343, 3385, 3397, 3963], 'decreased': [86, 262], 'expression': [87, 263, 1615, 1649, 1801, 3804, 3904, 4126, 4144], 'markedly': [90, 266], 'elevates': [91, 267], 'generation,': [94, 270], 'DNA': [95, 271, 1757, 1819, 2099, 2543, 2579, 2623, 2629, 3561], 'fragmentation,': [96, 272, 2544, 2624], 'lipid': [97, 273, 1629, 2924], 'peroxidation,': [98, 274, 2925], 'concurrent': [100, 276, 1476], 'with': [103, 279, 1061, 1475, 1638, 1643, 1904, 1944, 2427, 2461, 2515, 2522, 2684, 2695, 2752, 2879, 2917, 2935, 2988, 3002, 3050, 3058, 3102, 3145, 3156, 3222, 3464, 3504, 3558, 3589, 3679, 4047, 4066, 4081, 4133], 'a': [104, 137, 156, 166, 280, 313, 332, 342, 844, 882, 1004, 1129, 1279, 1430, 1597, 1672, 1724, 1732, 1777, 1791, 1872, 1930, 1945, 1975, 2083, 2516, 2534, 2735, 2814, 2823, 2910, 2918, 2962, 3108, 3263, 3293, 3495, 3535, 3836, 4096], 'significant': [105, 281], 'reduction': [106, 282], 'ATP': [108, 284, 1072, 3186, 3258, 3306, 3322], 'level.': [109, 285], 'Conversely,': [110, 286], 'overproduction': [111, 287], 'protein': [114, 290, 3600, 3661, 3671, 3692, 3763, 3789, 4147], 'efficiently': [115, 291], 'protected': [116, 292], 'cells': [118, 294, 805, 1106, 1641, 1739, 1831, 1868, 1895, 1995, 2042, 2060, 2175, 2455, 2501, 2545, 2834, 2873, 2902, 2926, 2958, 3119, 3165, 3500, 3980, 3988, 4005, 4013, 4020, 4046, 4056, 4080, 4094, 4131, 4136, 4139, 4164, 4358, 4387], 'from': [119, 295, 707, 1288, 1653, 1731, 1865, 1993, 2040, 2058, 2173, 2768, 2835, 3327, 3546, 3722, 3793, 4251, 4261, 4271, 4281, 4291, 4305, 4316], 'The': [122, 298, 377, 1741, 1755, 1814, 1860, 1961, 1990, 2211, 2485, 2510, 2952, 3029, 3139, 3380, 3449, 3690, 3748, 3841, 3970], 'protective': [123, 299], 'may': [130, 306], 'be': [131, 307, 1176, 1246, 1377], 'attributed': [132, 308], 'to': [133, 309, 496, 1070, 1087, 1175, 1368, 1376, 1428, 1680, 1726, 1879, 1954, 1983, 2003, 2012, 2052, 2073, 2215, 2547, 2655, 2721, 2733, 2822, 2887, 3042, 3107, 3151, 3268, 3372, 3702, 3889, 4089, 4196], 'increased': [134, 310, 1623, 1648, 1682, 4125], 'levels': [135, 311, 3187, 3842, 3867, 3895, 3901], 'reducing': [138, 314, 1281], 'equivalent,': [139, 315], 'NADPH,': [140, 316, 1677, 3436], 'needed': [141, 317, 1686], 'mitochondria.': [148, 324, 1037, 1170], 'Our': [149, 325, 1587, 1663], 'results': [150, 326, 1664], 'strongly': [151, 327], 'indicate': [152, 328, 635], 'producer': [159, 335, 1674], 'thus': [164, 340], 'plays': [165, 341, 881, 1128], 'key': [167, 343, 1130], 'stress-induced': [174, 350], 'damage.AF212319': [175, 351], 'Control': [352], 'dehydrogenase.Journal': [367], 'Biological': [369], 'ChemistryVol.': [370], '276Issue': [371], '28PreviewDr.': [372], "Huh's": [373], 'name': [374], 'was': [375, 835, 1303, 1589, 1721, 1745, 1758, 1774, 1808, 1824, 1942, 1966, 2020, 2061, 2096, 2429, 2474, 2488, 2502, 2520, 2531, 2631, 2731, 2762, 2959, 3035, 3266, 3290, 3383, 3419, 3452, 3502, 3566, 3576, 3581, 3719, 3768, 3825, 3961, 3981, 4153, 4204], 'misspelled.': [376], 'correct': [378], 'spelling': [379], 'shown': [381], 'above.': [382], 'Full-Text': [383], 'PDF': [384, 657, 682, 828, 913, 971, 1020, 1345, 1456, 1561, 2140, 2263, 2392], 'Open': [385], 'Access': [386], 'glucose-6-phosphate': [390, 1299], 'NAD+-dependent': [395, 1390], 'cytosolic': [402, 1398], '3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium': [406, 2432], 'bromide': [407, 2433], '2′,7′-dichlorofluorescein': [408, 2769], 'fluorescence-activated': [409], 'cell': [410, 591, 1053, 1585, 1606, 2423, 2996, 4215, 4307, 4318], 'sorter': [411], 'malondialdehyde': [412, 2950], 'Cell': [413, 2529, 2691, 3071], 'stress': [418, 1317], '(ROS)1': [423], 'has': [424, 1425], 'been': [425, 1426, 1488], 'implicated': [426], 'several': [428, 920, 2220], 'human': [429, 2088, 3810, 3829, 3847, 3906], 'diseases': [430], 'aging,': [432], 'alcohol-mediated': [433], 'organ': [434], 'damage,': [435], 'neurodegenerative': [436], 'diseases,': [437, 443], 'many': [438], 'types': [439], 'cancers,': [441], 'cardiovascular': [442], 'UV-mediated': [445], 'skin': [446], 'disorders': [447], '(1Ames': [448], 'B.N.': [449], 'Shigenaga': [450], 'M.K.': [451], 'Hagen': [452], 'T.M.': [453], 'Proc.': [454, 536, 859, 1190, 1221, 1840], 'Natl.': [455, 537, 860, 1191, 1222, 1841], 'Acad.': [456, 538, 861, 1192, 1223, 1842], 'Sci.': [457, 539, 862, 1193, 1224, 1843], 'U.': [458, 540, 863, 1194, 1225, 1844], 'S.': [459, 529, 541, 864, 1109, 1195, 1226, 1330, 1332, 1845, 2377, 2379, 2441, 2600], 'A.': [460, 481, 531, 542, 865, 896, 900, 1189, 1196, 1220, 1227, 1326, 1328, 1846, 2373, 2375], '1993;': [461, 652, 1521, 1713, 1847, 2164, 3526, 3647], '90:': [462, 1848], '7913-7922Crossref': [463], 'Scopus': [464, 488, 514, 547, 585, 629, 659, 684, 748, 789, 830, 870, 915, 951, 973, 1022, 1121, 1201, 1232, 1262, 1347, 1525, 1563, 1717, 1851, 2142, 2168, 2265, 2281, 2340, 2354, 2394, 2406, 2449, 2614, 2671, 2866, 2975, 3210, 3361, 3412, 3485, 3530, 3623, 3651, 3744], '(5418)': [465], 'Google': [466, 490, 516, 549, 587, 631, 661, 686, 721, 750, 791, 832, 872, 917, 953, 975, 1024, 1123, 1203, 1234, 1264, 1349, 1458, 1527, 1565, 1719, 1788, 1853, 2144, 2170, 2267, 2283, 2342, 2356, 2396, 2408, 2451, 2616, 2673, 2799, 2868, 2977, 3212, 3363, 3414, 3487, 3532, 3625, 3653, 3746], 'Scholar).': [467, 550, 632, 792, 833, 918, 976, 1235, 1350, 1418, 1459, 1566, 2145, 2357, 2409, 2452, 2617, 2674, 2800, 2869, 2978, 3213, 3415, 3488, 3747], 'As': [468], 'one': [469, 3556, 3855], 'sources': [473], '(2Chance': [476], 'B.': [477, 621], 'Sies': [478, 3404], 'H.': [479, 665, 2399, 3405, 3732], 'Boveris': [480], 'Physiol.': [482], 'Rev.': [483], '1979;': [484], '59:': [485], '527-605Crossref': [486], 'PubMed': [487, 513, 546, 584, 628, 658, 683, 720, 747, 788, 829, 869, 914, 950, 972, 1021, 1120, 1200, 1231, 1261, 1346, 1457, 1524, 1562, 1716, 1850, 2141, 2167, 2264, 2280, 2339, 2353, 2393, 2405, 2448, 2613, 2670, 2865, 2974, 3209, 3411, 3484, 3529, 3622, 3650, 3743], '(4830)': [489], 'Scholar),': [491, 517, 1025, 1124, 2284, 3626], 'highly': [494], 'susceptible': [495], 'can': [500, 520, 556], 'enzymes': [503, 992, 4176, 4236], 'directly': [504, 800], '(3Lenaz': [505], 'G.': [506, 740, 783, 2332], 'Biochim.': [507, 622, 1255], 'Biophys.': [508, 623, 1116, 1256], 'Acta.': [509, 624, 1257], '1998;': [510, 625, 717], '1366:': [511, 626], '53-67Crossref': [512], '(569)': [515], 'they': [519], 'cause': [521, 639], 'mutation': [522], 'DNAs': [525], '(4Esposito': [526], 'L.A.': [527], 'Melov': [528], 'Panov': [530], 'Cottrell': [532], 'B.A.': [533], 'Wallace': [534], 'D.C.': [535], '1999;': [543, 675, 744, 785, 821, 1013, 1338, 1554, 2133, 2256, 2385], '96:': [544], '4820-4825Crossref': [545], '(537)': [548], 'At': [551, 3162], 'same': [553, 2107, 3456], 'time,': [554], 'change': [557], 'transmembrane': [560], 'potential': [561, 1164, 1573], '(Δψm),': [562], 'which': [563, 704, 1095, 1468, 3886], 'indicative': [565], 'membrane': [568, 2086], 'integrity': [569], '(5Huang': [570], 'P.': [571, 769, 813, 2602, 2789, 3734], 'Feng': [572], 'L.': [573, 1447, 3617, 3730], 'Oldham': [574], 'E.A.': [575], 'Keating': [576], 'M.J.': [577], 'Plunkett': [578], 'W.': [579, 858, 2347, 2604], 'Nature.': [580, 784], '2000;': [581], '407:': [582], '390-395Crossref': [583], '(749)': [586], 'Scholar)': [588, 687, 873, 954, 1204, 1265, 1528, 1720, 1789, 1854, 2171, 2268, 3364, 3533, 3654], 'precedes': [590], 'death': [592, 1054, 1607], 'toxic': [596], 'compounds': [597], 'cytokines': [599, 956], '(6Lemasters': [600], 'J.J.': [601], 'Nieminen': [602], 'A.L.': [603], 'Qian': [604], 'T.': [605, 667, 809, 945, 2860], 'Trost': [606], 'L.C.': [607], 'Elmore': [608], 'S.P.': [609, 2664], 'Nishimura': [610], 'Y.': [611, 671], 'Crowe': [612], 'R.A.': [613], 'Cascio': [614], 'W.E.': [615], 'Bradham': [616], 'C.A.': [617], 'Brenner': [618, 731], 'D.A.': [619, 807, 2783], 'Herman': [620], '177-196Crossref': [627], '(1227)': [630], 'Recent': [633], 'reports': [634, 1039], 'apoptosis': [640, 711, 802], '(7Hockenbery': [641], 'D.M.': [642], 'Oltvai': [643], 'Z.N.': [644], 'Yin': [645], 'X.-M.': [646], 'Milliman': [647], 'C.L.': [648], 'Korsmeyer': [649], 'S.J.': [650, 3353], 'Cell.': [651, 1012, 3738], '75:': [653], '241-251Abstract': [654], 'Full': [655, 678, 680, 824, 826, 909, 911, 967, 969, 1016, 1018, 1341, 1343, 1454, 1557, 1559, 2136, 2138, 2259, 2261, 2388, 2390], 'Text': [656, 679, 681, 825, 827, 910, 912, 968, 970, 1017, 1019, 1342, 1344, 1455, 1558, 1560, 2137, 2139, 2260, 2262, 2389, 2391], '(3294)': [660], 'Scholar,8Nomura': [662], 'K.': [663, 856, 943, 1252, 2858], 'Imai': [664], 'Koumura': [666], 'Arai': [668], 'M.': [669, 771, 898, 2793], 'Nakagawa': [670], 'J.': [672, 741, 765, 817, 853, 903, 961, 1216, 1335, 1448, 1520, 1551, 1712, 2130, 2163, 2253, 2275, 2334, 2349, 2382, 2794, 3203, 3525, 3646, 3736, 3737], 'Biol.': [673, 904, 962, 1336, 1449, 1552, 2131, 2254, 2383], 'Chem.': [674, 905, 963, 1337, 1450, 1553, 2132, 2255, 2384], '274:': [676, 1339, 1555, 2134, 2257, 2386], '29294-29302Abstract': [677], '(257)': [685], 'activating': [689], 'apoptotic': [691, 878], 'effectors': [692], 'such': [693, 4177], 'cytochromec': [695], 'release,': [696], 'procaspase-2,': [697], 'procaspase-9,': [698], 'procaspase-3,': [699], 'latent': [701], 'apoptosis-inducing': [702], 'factor,': [703, 1006], 'released': [706], 'during': [710], '(9Green': [712], 'D.R.': [713, 775], 'Reed': [714, 1253], 'J.C.': [715, 902], 'Science.': [716, 946, 2609, 2861], '281:': [718], '1309-1312Crossref': [719], 'Scholar,': [722, 751, 2343, 2397], '10Susin': [723], 'S.A.': [724, 753], 'Lorenzo': [725, 754], 'H.K.': [726, 755], 'Zamzami': [727, 756], 'N.': [728, 734, 757, 773], 'Marzo': [729, 758], 'I.': [730, 759], 'C.': [732, 894, 2596], 'Larochette': [733, 772], 'Prevost': [735], 'M.C.': [736, 2791], 'Alzari': [737], 'P.M.': [738], 'Kroemer': [739, 782], 'Exp.': [742], 'Med.': [743], '189:': [745], '381-394Crossref': [746], '(637)': [749], '11Susin': [752], 'Snow': [760], 'B.E.': [761], 'Brothers': [762], 'G.M.': [763, 2274], 'Mangion': [764], 'Jacotot': [766], 'E.': [767], 'Costantini': [768], 'Loeffler': [770], 'Goodlett': [774], 'Aebersold': [776], 'R.': [777], 'Siderovski': [778], 'D.P.': [779], 'Penninger': [780], 'J.M.': [781], '397:': [786], '441-446Crossref': [787], '(3452)': [790], 'Another': [793], 'also': [795, 836, 880], 'suggested': [796, 1957], 'caused': [801], 'T': [804], '(12Hildeman': [806], 'Mitchell': [808], 'Teague': [810], 'T.K.': [811], 'Henson': [812], 'Day': [814], 'B.J.': [815, 1516, 1548, 1708, 2127, 2159, 2250, 3521, 3642], 'Kappler': [816], 'Marrack': [818], 'P.C.': [819], 'Immunity.': [820], '10:': [822], '735-744Abstract': [823], '(407)': [831], 'It': [834], 'reported': [837, 1492, 3725], 'tumor': [839, 886], 'necrosis': [840, 887], 'factor': [841, 888, 1001, 1008], 'α': [842], 'causes': [843], 'rapid': [845, 1206], 'production': [846, 1477, 1625, 2232, 2306], '(13Goossens': [850], 'V.': [851], 'Grooten': [852], 'De': [854], 'Vos': [855], 'Fiers': [857], '1995;': [866, 947, 964, 2862], '92:': [867], '8115-8119Crossref': [868], '(556)': [871], 'ceramide,': [876], 'an': [877, 1041, 1139, 1681, 1920, 2030, 2523, 3146, 3260, 3334, 3590, 3751], 'stimulus,': [879], 'crucial': [883, 1367], 'α-induced': [889], 'generation': [892, 2761], '(14Garcia-Ruiz': [893], 'Colell': [895], 'Mari': [897], 'Morales': [899], 'Fernandez-Checa': [901], '1997;': [906, 1117, 2445], '272:': [907], '11369-11377Abstract': [908], '(715)': [916], 'Furthermore,': [919], 'other': [921, 1530, 3880, 4173, 4235], 'investigators': [922], 'demonstrated': [923], 'involved': [927, 4237], 'signaling': [930], 'pathway': [931, 1058], 'certain': [933], 'growth': [934, 1000, 1065], 'factors': [935], '(15Sundaresan': [936, 2851], 'M.,': [937, 2852], 'Yu,': [938, 2853], 'Z.-X.': [939, 2854], 'Ferrans': [940, 2855], 'C.J.': [941, 2856], 'Irani': [942, 2857], 'Finkel': [944, 2859], '270:': [948, 965, 2863], '296-299Crossref': [949, 2864], '(2314)': [952, 2867], '(16Lo': [957], 'Y.Y.C.': [958], 'Cruz': [959], 'T.F.': [960], '11727-11730Abstract': [966], '(471)': [974], 'In': [977, 1236, 1379, 1567, 1646, 1797, 3781, 3878, 4051, 4201], 'addition,': [978, 3782, 4202], 'ROS,': [980], 'under': [981, 1922, 2639], 'hypoxic': [982], 'conditions,': [983], 'activate': [984], 'transcription': [986], 'genes': [989], 'glycolytic': [991], 'well': [994], 'erythropoietin': [996], 'vascular': [998], 'endothelial': [999], 'up-regulating': [1003], 'transcriptional': [1005], 'hypoxia-inducible': [1007], '1': [1009, 2179, 2292, 2308, 2553, 2568, 2689, 2940, 2993, 3003, 3430, 3465, 3475, 3769], '(17Semenza': [1010], 'G.L.': [1011], '98:': [1014], '281-284Abstract': [1015], '(333)': [1023], 'suggesting': [1026, 4223], 'mediate': [1030], 'cross-talk': [1031], 'between': [1032, 1210, 4079], 'nucleus': [1034], 'These': [1038, 1270, 4034], 'suggest': [1040], 'important': [1042], 'regulation': [1048], 'homeostasis': [1051], 'signal': [1056, 3688], 'transduction': [1057], 'after': [1059, 2425, 2771, 3462, 3931], 'treatments': [1060], 'agents': [1063], 'or': [1064, 1659, 1768, 1793, 1804, 1821, 2089, 2682, 2750, 2933, 2986, 3048, 3220, 3947, 4083, 4162], 'factors.': [1066], 'During': [1067], 'aerobic': [1068], 'respiration': [1069], 'generate': [1071], 'mitochondria,': [1074, 1358], 'leakage': [1075], 'electrons': [1077], 'frequently': [1078], 'produces': [1079], 'superoxide': [1081, 1091, 2315, 4187], 'anions': [1082], 'rapidly': [1085], 'reduced': [1086, 1136, 1660], 'H2O2': [1088, 1167, 2428, 2551, 2687, 2755, 2938, 2991], 'manganese': [1090, 2314, 4186], 'dismutase.': [1092], 'Because': [1093, 1351], 'catalase,': [1094], 'metabolizes': [1096], 'H2O2,': [1097, 2465], 'absent': [1099, 1355], 'most': [1104, 3858], 'animal': [1105], '(18Esworthy': [1107], 'R,': [1108], 'Ho': [1110], 'Y.S.': [1111], 'Chu': [1112], 'F.F.': [1113], 'Arch.': [1114], 'Biochem.': [1115, 1519, 1711, 2162, 2335, 2348, 2666, 3357, 3524, 3645, 3739], '340:': [1118], '59-63Crossref': [1119], '(134)': [1122], 'metabolizing': [1133], 'H2O2.': [1134], 'Therefore,': [1135], '(GSH),': [1138], 'efficient': [1140], 'antioxidant': [1141, 4175], 'free': [1143], 'radical': [1144], 'scavenger': [1145], 'itself': [1147], 'activity': [1152, 1292, 2296, 4105, 4254, 4264, 4274, 4284, 4294, 4299, 4310], 'peroxidase,': [1156, 4181], 'becomes': [1157], 'best': [1159], 'available': [1161], 'toxicity': [1165], 'Nevertheless,': [1171], 'GSH': [1172, 1209, 1287, 1321, 1684, 3381, 3417, 3460], 'known': [1174], 'synthesized': [1177, 1943], 'cytosol': [1180, 1212, 1250, 4158], 'transported': [1182], 'into': [1183, 1248, 1268, 1473, 1748, 1776, 1826, 1881, 3569], '(19Griffith': [1186], 'O.W.': [1187], 'Meister': [1188, 1219], '1985;': [1197, 3206, 3481], '82:': [1198], '4668-4672Crossref': [1199], '(445)': [1202], 'exchange': [1207], '(20Martensson': [1215], 'Lai': [1217], 'J.C.K.': [1218], '1990;': [1228], '87:': [1229], '7185-7189Crossref': [1230], '(263)': [1233], 'contrast,': [1237, 1647, 3879, 4052], 'oxidized': [1238], 'disulfide': [1240], '(GSSG)': [1241], 'cannot': [1245], 'exported': [1247], '(21Olafsdottier': [1251], 'D.J.': [1254], '1988;': [1258], '964:': [1259], '377-382Crossref': [1260], '(160)': [1263], 'reconversion': [1267], 'GSH.': [1269], 'facts': [1271], 'underscore': [1272], 'importance': [1274], 'necessary': [1280], 'equivalent': [1282], 'GSSG': [1289, 3450], 'reductase.': [1296], 'Until': [1297], 'now,': [1298], '(Glu-6-P': [1301], 'dehydrogenase)': [1302], 'regarded': [1304], 'source': [1308], 'because': [1312, 4099], 'it': [1313], 'reduces': [1314], 'increasing': [1319], 'concentration': [1322, 2948, 2953], '(22Salvemini': [1323, 2370], 'F.': [1324, 2371], 'Franze': [1325, 2372], 'Iervolino': [1327, 2374], 'Filosa': [1329, 2376], 'Salzano': [1331, 2378], 'Ursini': [1333, 2380], 'M.V.': [1334, 2381], '2750-2757Abstract': [1340, 2387], '(297)': [1348, 2395], 'Glu-6-P': [1352, 2360, 4208], 'mechanism': [1360], 'maintaining': [1362], 'pool,': [1366], 'control': [1370, 1640, 2538, 3979, 4045, 4069, 4135, 4163, 4198, 4221], 'balance,': [1374], 'remains': [1375], 'elucidated.': [1378, 1489], 'mammals,': [1380], 'three': [1381, 4397], 'classes': [1382], '(ICDH)': [1386], 'isoenzymes': [1387], 'exist:': [1388], 'ICDH': [1391, 1395, 1400, 1422], '(IDH),': [1392], '(IDPc)': [1401], '(23Plaut': [1402], 'G.W.E.': [1403], 'Gabriel': [1404], 'J.L.': [1405], 'Biochemistry': [1406], 'Metabolic': [1408], 'Process.': [1409], 'Elsevier': [1410], 'Science': [1411], 'Publishing': [1412], 'Co.,': [1413, 3180], 'Inc.,': [1414, 2048], 'New': [1415], 'York1983:': [1416], '285-301Google': [1417], 'Among': [1419], 'eukaryotic': [1421], 'isoenzymes,': [1423], 'IDH': [1424, 1531, 2225, 4171], 'assumed': [1427], 'play': [1429], 'decarboxylation': [1436, 1470], 'tricarboxylic': [1441], 'acid': [1442, 3014, 3771], 'cycle': [1443], '(24Cupp': [1444], 'J.R.': [1445], 'McAlister-Henn': [1446, 3616], '1991;': [1451], '266:': [1452], '22199-22205Abstract': [1453], 'However,': [1460, 3710, 4150], 'exact': [1462], 'roles': [1463], 'IDPc,': [1467], 'catalyze': [1469], 'α-ketoglutarate': [1474], 'cytosol,': [1484], 'respectively,': [1485, 2285, 4041, 4064], 'have': [1486, 1491], 'not': [1487, 3587, 3968, 4154, 4166, 4230], 'previously': [1493, 2111, 3401, 3724], 'isolation': [1495], 'molecular': [1497], 'characterization': [1498], 'cDNA': [1500, 1598, 1622, 1656, 1696, 1730, 1735, 1744, 1773, 1807, 2081, 3496, 3506, 3539, 3580], 'clones': [1501, 3540], 'bovine': [1503, 1908, 3508, 3705], '(25Huh': [1505, 1697, 2148, 3510, 3631], 'T.-L.': [1506, 1550, 1698, 2129, 2149, 2252, 3511, 3632], 'Ryu': [1507, 1699, 2150, 3512, 3633], 'J.H.': [1508, 1700, 2151, 3513, 3634], 'Huh': [1509, 1541, 1549, 1701, 2120, 2128, 2152, 2243, 2251, 3514, 3635], 'J.W.': [1510, 1702, 2153, 2785, 3515, 3636], 'Sung': [1511, 1703, 2154, 3516, 3637], 'H.C.': [1512, 1704, 2155, 3517, 3638], 'Oh': [1513, 1705, 2156, 3518, 3639], 'I.-U.': [1514, 1706, 2157, 3519, 3640], 'Song': [1515, 1547, 1707, 2126, 2158, 2249, 3520, 3641], 'Veech': [1517, 1709, 2160, 3522, 3643], 'R.L.': [1518, 1710, 2161, 3523, 3644], '292:': [1522, 1714, 2165, 3527, 3648], '705-710Crossref': [1523, 1715, 2166, 3528, 3649], '(35)': [1526, 1718, 2169, 3531, 3652], 'subunits': [1532], '(26Kim': [1533, 2112, 2235], 'Y.-O.': [1534, 2113, 2236], 'Koh': [1535, 2114, 2237], 'H.-J.': [1536, 2115, 2238], 'Kim': [1537, 2116, 2239], 'S.-H.': [1538, 1540, 2117, 2119, 2240, 2242], 'Jo': [1539, 2118, 2241], 'J.-W.': [1542, 2121, 2244], 'Jeong': [1543, 2122, 2245], 'K.-S.': [1544, 2123, 2246], 'Lee': [1545, 2124, 2247, 3352], 'J.I.': [1546, 2125, 2248], '36866-36875Abstract': [1556, 2135, 2258], '(42)': [1564, 2143, 2266], 'study,': [1569], 'we': [1570, 4086], 'death.': [1586], 'study': [1588], 'performed': [1590, 2584], 'overproducing': [1592], 'coding': [1594, 3601], 'region': [1595, 3602], 'mouse': [1600, 1728, 1939, 2079, 2090, 3493, 3542, 3629, 3659, 3695, 3717, 3726, 3779, 3797, 3812, 3831, 3849, 3908], 'followed': [1602, 2884], 'measurement': [1604, 2722], 'indicators': [1610], 'stress.': [1613], 'Reduced': [1614], 'transfecting': [1619], 'antisense': [1621, 1794, 1805, 3942, 4084], 'spontaneous': [1624], 'peroxidation': [1630], 'accompanied': [1631], 'significantly': [1633, 3872, 4142], 'more': [1634], 'injury': [1636], 'compared': [1637, 4065, 4132], 'transfected': [1642, 1825, 3958], 'vector': [1644, 1779, 4049], 'alone.': [1645, 4050], 'derived': [1652], 'sense': [1655, 1792, 1803, 3936, 4082], 'effectively': [1657], 'prevented': [1658], 'ROS-related': [1661], 'further': [1665, 1765, 4122], 'provide': [1666], 'evidence': [1667], 'ROS-inducible': [1669], 'subsequently': [1678, 2010], 'leading': [1679], 'pool': [1685, 3376], 'ROS-mediated': [1691, 4077], 'injury.': [1693], 'Bovine': [1694], 'used': [1722, 1878, 1982, 2214, 2732], 'probe': [1725], 'screen': [1727], 'λ-ZAP': [1733], 'II': [1734], 'library': [1736, 3497], 'NIH3T3': [1738, 1882, 1885, 1894, 3499, 4244], '(Stratagene).': [1740], 'largest': [1742, 3560], 'initially': [1746], 'subcloned': [1747, 3568], 'EcoRI': [1750], 'site': [1751], 'pGEM7': [1753], '(Promega).': [1754], 'resultant': [1756], 'digested': [1759, 1764], 'byApaI,': [1760], 'blunt-ended,': [1761], 'then': [1763, 2021, 3105], 'eitherHindIII': [1767], 'ClaI': [1769], 'before': [1770], 'ligated': [1775], 'LNCX-retroviral': [1778, 1799], '(27Miller': [1780], 'A.D.': [1781], 'Rosman': [1782], 'G.T.': [1783], 'BioTechniques.': [1784], '1989;': [1785, 2610], '7:': [1786], '980-990PubMed': [1787], 'orientation,': [1795], 'respectively.': [1796, 3709, 4033], 'vector,': [1800], 'directed': [1809], 'cytomegalovirus': [1812], 'promoter.': [1813], 'respective': [1815], 'two': [1816, 3132, 3548, 3921], 'recombinant': [1817, 3926], 'constructs': [1820, 3960], 'LNCX-vector': [1822, 3948], 'alone': [1823, 3949], 'BOSC23': [1828], 'retroviral': [1829], 'packaging': [1830, 1867], '(28Pear': [1832], 'W.S.': [1833], 'Nolan': [1834], 'G.P.': [1835], 'Scott': [1836], 'M.L.': [1837], 'Baltimore': [1838], 'D.': [1839], '8392-8396Crossref': [1849], '(2301)': [1852], 'calcium': [1857], 'phosphate': [1858, 3083, 3425], 'method.': [1859], 'retrovirus': [1861], 'particles': [1862], 'were': [1863, 1887, 1896, 1996, 2043, 2105, 2176, 2213, 2228, 2324, 2364, 2414, 2456, 2555, 2583, 2645, 2679, 2693, 2742, 2811, 2838, 2847, 2877, 2903, 2930, 2983, 3000, 3045, 3073, 3092, 3120, 3135, 3143, 3169, 3188, 3228, 3309, 3312, 3325, 3341, 3544, 3816, 3851, 3911, 3929, 4189], 'separated': [1864, 1997, 2062], 'filtration': [1870], 'sterile': [1873], 'filter': [1874], '(0.4-μm': [1875], 'diameter)': [1876], 'transfect': [1880], 'cells.': [1883, 2539, 4000, 4116], 'Stable': [1884], 'transformants': [1886, 3923], 'identified': [1888], 'presence': [1891], 'G418.': [1893], 'grown': [1897, 2415, 2743, 3041], "Dulbecco's": [1899], 'modified': [1900], "Eagle's": [1901], 'medium': [1902], 'supplemented': [1903], '10%': [1905, 1999], '(v/v)': [1906, 3078], 'fetal': [1907], 'serum': [1909, 1970], '(Hyclone': [1910], 'Laboratories)': [1911], '10': [1913, 2201, 2565, 2774], 'μg/ml': [1914], 'gentamycin': [1915], 'at': [1916, 2194, 2205, 2286, 2289, 2482, 2512, 2714, 2726, 2905, 3023, 3037, 3065, 3088, 3182, 3247, 3330, 3389], '37': [1917, 2483], '°C': [1918, 2716, 3025, 3249], 'incubator': [1921], '5%': [1923], 'CO2.': [1924], 'To': [1925, 2618, 2828, 3489, 3801, 3914, 4072], 'prepare': [1926, 1984], 'polyclonal': [1928, 1985], 'antibody,': [1929], 'peptide': [1931, 1946, 1963, 3756], 'representing': [1932], 'N-terminal': [1934], '16': [1935], 'amino': [1936, 3664, 3675, 3683, 3758, 3766, 3770, 3784], 'acids': [1937, 3665, 3676, 3684, 3785], '(ADKRIKVAKPVVEMDG)': [1941], 'synthesizer': [1947], '(Excell,': [1948], 'Milligene': [1949], 'Bioresearch)': [1950], 'purified': [1952, 1962], 'according': [1953, 2051], 'protocol': [1956], 'manufacturer.': [1960], '(5': [1964, 3215], 'mg)': [1965, 1973], 'conjugated': [1967], 'rabbit': [1969], 'albumin': [1971], '(1': [1972, 2739], 'using': [1974, 2015, 2024, 2045, 2813, 2909, 3111, 3173, 3191, 3333, 4119], 'kit': [1976, 2034], '(Imject,': [1977], 'Pierce': [1978], 'Chemical': [1979], 'Co.)': [1980], 'anti-peptide': [1986, 2016], 'antibodies': [1987], 'rabbit.': [1989], 'homogenates': [1992], 'cultured': [1994, 2041, 2059, 2174], 'on': [1998, 2065, 2633, 2744, 3255], 'SDS-polyacrylamide': [2000], 'gel,': [2001], 'transferred': [2002, 2072, 3150], 'nitrocellulose': [2004], 'membranes': [2005], '(Schleicher': [2006], '&': [2007], 'Shuell),': [2008], 'subjected': [2011, 3106], 'immunoblot': [2013], 'analysis': [2014, 3608, 4118], 'antibodies.': [2017], 'Immunoreactive': [2018], 'antigen': [2019], 'recognized': [2022], 'horseradish': [2025], 'peroxidase-labeled': [2026], 'anti-rabbit': [2027], 'IgG': [2028], 'enhanced': [2031], 'chemiluminescence': [2032], 'detection': [2033], '(Amersham': [2035], 'Pharmacia': [2036], 'Biotech).': [2037], 'Total': [2038, 2056, 2642, 3416], 'RNAs': [2039], 'prepared': [2044, 2172], 'RNAzol': [2046], '(Tel-Test': [2047], 'Friendswood,': [2049], 'TX)': [2050], "manufacturer's": [2054], 'protocol.': [2055], 'RNA': [2057], 'electrophoresis': [2064], '0.66': [2066], 'm': [2067, 3082, 3423], 'formamide,': [2068], '1%': [2069, 2572, 2634, 3095], 'agarose': [2070, 2635], 'gels,': [2071], 'GeneScreen': [2074], 'membranes,': [2075], 'hybridized': [2077, 2097], 'with32P-labeled': [2078, 2098], 'probe.': [2084, 2100, 3536], 'A': [2085], 'multiple': [2091], 'tissue': [2092], 'Northern': [2093, 3814], 'blot': [2094], '(CLONTECH)': [2095], 'Hybridization': [2101], 'procedures': [2104], 'those': [2109], 'described': [2110, 2369, 2588, 2850, 3400], 'Mitochondrial': [2146], 'pellets': [2147, 3072], 'resuspended': [2177, 3232], '×': [2180, 2207, 2412, 2677, 2740, 2875, 2928, 2981, 3216, 3394], 'phosphate-buffered': [2181, 3059], 'saline': [2182], 'containing': [2183, 2571, 3282, 3429], '0.1%': [2184], 'Triton': [2185], 'X-100,': [2186], 'disrupted': [2187], 'sonication': [2189], '(4710': [2190], 'series,': [2191], 'Cole-Palmer)': [2192], 'twice': [2193, 3057], '40%': [2195], 'maximum': [2198], 'setting': [2199], 's,': [2202], 'centrifuged': [2204, 3064], '15,000': [2206], 'gfor': [2208], '30': [2209, 2718, 2888, 3099, 3437], 'min.': [2210, 2758, 2895, 3028, 3070], 'supernatants': [2212], 'measure': [2216, 2829], 'activities': [2218, 4212, 4233, 4242, 4249, 4259, 4269, 4279, 4289, 4303, 4314, 4353, 4382], 'enzymes.': [2222], 'Activities': [2223, 2312, 2358, 4168], 'measured': [2229, 2960, 3420, 3453, 4250, 4260, 4270, 4280, 4290, 4304, 4315], 'NADH': [2234], '(29Loverde': [2271], 'A.W.': [2272], 'Lehrer': [2273], 'Neurochem.': [2276], '1973;': [2277], '20:': [2278], '441-448Crossref': [2279], '(33)': [2282], '340': [2287], 'nm': [2288, 2514, 2518, 3332, 3391], '25': [2290, 2712], '°C.': [2291, 2484, 3090], 'unit': [2293, 3444], 'defined': [2298], 'amount': [2301], 'enzyme': [2303, 4241], 'catalyzing': [2304], 'μmol': [2309], 'NADPH/min.': [2311], 'dismutase,': [2316, 4188], 'reductase,': [2319, 4184], 'determined': [2325, 3036, 3189, 3342], 'published': [2327], 'methods': [2328, 2368], '(30Marklund': [2329], 'S.L.': [2330], 'Marklund': [2331], 'Eur.': [2333], '1974;': [2336], '47:': [2337], '469-474Crossref': [2338], '(8071)': [2341], '31Pinto': [2344], 'R.E.': [2345], 'Bartley': [2346], '1969;': [2350], '112:': [2351], '109-115Crossref': [2352], '(350)': [2355], 'catalase': [2363, 4211], 'analyzed': [2365, 2943, 3384], '32Aebi': [2398], 'Method.': [2400], 'Enzymol.': [2401, 2970, 3407, 3480], '1984;': [2402], '105:': [2403], '121-126Crossref': [2404], '(18681)': [2407], 'Cells': [2410, 2675, 2738, 2979, 3040, 3091, 3214], '(2': [2411, 2470, 2676, 2874, 2927, 2980], '104)': [2413], 'until': [2416], '80%': [2417, 3043], 'confluence': [2418, 3044], '96-well': [2420], 'plates,': [2421], 'viability': [2424, 2530], 'treatment': [2426, 3463], 'assessed': [2430], '(MTT)': [2434], 'assay': [2435, 2526, 2964], '(33Matteo': [2436], 'M.A.': [2437], 'Loweth': [2438], 'A.C.': [2439], 'Thomas': [2440, 2792], 'Mabley': [2442], 'J.G.': [2443], 'Apoptosis.': [2444], '2:': [2446], '164-177Crossref': [2447], '(53)': [2450], 'After': [2453], 'treated': [2457, 2751, 3221], '48': [2459], 'h': [2460, 2481, 2554, 2941, 3087, 3227, 3476], 'concentrations': [2463, 2549, 2644], '50': [2466, 3066], 'μl': [2467, 2506, 3235, 3270, 3466, 3471], 'MTT': [2469, 2486], 'mg/ml,': [2471], 'Sigma)': [2472, 2892], 'solution': [2473, 2487, 3009, 3238, 3273, 3324], 'added': [2475, 3267], 'incubated': [2477, 2694], 'another': [2479], '4': [2480, 3089, 3242, 3251], 'discarded': [2489], 'aspiration,': [2491], 'resulting': [2494], 'formazan': [2495], 'product': [2496], 'converted': [2497], 'viable': [2500], 'dissolved': [2503], '150': [2505], 'dimethyl': [2508], 'sulfoxide.': [2509], 'absorbance': [2511, 2725, 3030, 3329], '540': [2513], '620': [2517], 'reference': [2519], 'read': [2521], 'enzyme-linked': [2524], 'immunosorbent': [2525], 'plate': [2527], 'reader.': [2528], 'expressed': [2532, 3366, 3834, 3845], 'percentage': [2535], 'untreated': [2537, 2681, 2749, 2932, 2985, 3047, 3219], 'For': [2540, 2870, 2922, 3115, 3257, 3303], 'analyses': [2541, 3815], 'exposed': [2546], 'different': [2548, 2957, 3721, 3792, 3809, 3922], 'lysed': [2556], 'NTE': [2558], 'buffer,': [2559], 'pH': [2560, 3019, 3061, 3244, 3280], '8.0': [2561], '(100': [2562], 'mm': [2563, 2566, 2569, 2686, 2700, 2704, 2709, 2754, 2937, 2990, 3240, 3275, 3278, 3431], 'NaCl,': [2564], 'Tris,': [2567], 'EDTA)': [2570], 'SDS': [2573], 'proteinase': [2575], 'K': [2576], '(0.2': [2577], 'mg/ml).': [2578], 'extraction': [2580, 3237], 'purification': [2582], 'method': [2587, 3345, 3399], 'Bernhard': [2590], 'et': [2591, 3348], 'al.': [2592, 3349], '(34Bernhard': [2593], 'C.T.': [2594], 'Klas': [2595], 'Peters': [2597], 'A.M.J.': [2598], 'Matzku': [2599], 'Moller': [2601], 'Falk': [2603], 'Debatin': [2605], 'K.-M.': [2606], 'Krammer': [2607], 'P.H.': [2608], '245:': [2611], '301-304Crossref': [2612], '(1667)': [2615], 'analyze': [2619], 'degree': [2621], '5': [2625, 2757, 2880, 3069], 'μg': [2626, 3284, 3438], 'each': [2628, 2836, 3167, 3925, 4193], 'sample': [2630, 3168, 3265], 'resolved': [2632], 'gel': [2636], 'visualized': [2638], 'UV': [2640], 'illumination.': [2641], 'peroxide': [2643], 'calculated': [2646, 2848, 3326], 'rate': [2649], 'oxidation': [2651, 2772], 'ferrous': [2653, 2706], '(Fe2+)': [2654], 'ferric': [2656], 'ion': [2657], '(Fe3+)': [2658], '(35Jiang': [2659], 'Z.Y.': [2660], 'Hunt': [2661], 'J.V.': [2662], 'Wolff': [2663], 'Anal.': [2665, 3356], '1992;': [2667, 3619], '202:': [2668], '384-389Crossref': [2669], '(1462)': [2672], '106)': [2678, 2741, 2876, 2929, 2982, 3217], 'either': [2680, 2931, 2984, 3046, 3218], 'pretreated': [2683, 2878, 2934, 2987, 3049], '0.1': [2685, 2936, 2989, 3051, 3081, 3223, 3422], 'h.': [2690, 2994], 'extracts': [2692, 2997], 'reaction': [2697, 3272, 3966], 'mixture': [2698], '(0.1': [2699], 'xylenol': [2701], 'orange,': [2702], '0.25': [2703, 3016], 'ammonium': [2705], 'sulfate,': [2707], '100': [2708, 3024, 3269], 'sorbitol,': [2710], 'mmH2SO4)': [2713], '22': [2715], 'min': [2719], 'prior': [2720], '560': [2727], 'nm.': [2728, 3039, 3319], 'H2O2(0–5': [2729], 'μm)': [2730], 'standard': [2736, 3307], 'curve.': [2737], 'poly-l-lysine-coated': [2745], 'slide': [2746], 'glasses': [2747], '1.0': [2753], 'Intracellular': [2759, 3185], 'monitored': [2763], 'fluorescence': [2766, 2804, 2831, 2845, 2899], 'produced': [2767], '(DCF)': [2770], 'μm': [2775, 2889], 'dichlorodihydrofluorescein': [2776], 'diacetate': [2777, 2882], '(Molecular': [2778], 'Probes,': [2779], 'Eugene,': [2780], 'OR)': [2781], '(36Bass': [2782], 'Parce': [2784], 'Dechatelet': [2786], 'L.R.': [2787], 'Szejda': [2788], 'Seeds': [2790], 'Immunol.': [2795], '1983;': [2796], '130:': [2797], '1910-1917PubMed': [2798], 'Images': [2801], 'DCF': [2803, 2898], '(excitation,': [2805], '488': [2806], 'nm;': [2807], 'emission,': [2808], '520': [2809], 'nm)': [2810, 3142], 'acquired': [2812], 'laser': [2815], 'confocal': [2816], 'scanning': [2817], 'microscope': [2818, 2824, 3178], '(DM/R-TCS,': [2819], 'Leica)': [2820], 'coupled': [2821], '(Leitz': [2825], 'DM': [2826], 'RBE).': [2827], 'intensity,': [2832], '20': [2833, 3277], 'image': [2837], 'picked': [2839], 'randomly,': [2840], 'their': [2842], 'averages': [2843], 'intensity': [2846], 'FACS': [2871, 2911], 'analyses,': [2872], 'μmdichlorodihydrofluorescein': [2881], 'exposure': [2886], 'C2-ceramide': [2890], '(N-acetyl-d-sphingosine,': [2891], '15': [2894, 3027], 'Measurements': [2896], 'trypsin-treated': [2901], 'made': [2904], 'least': [2906, 3163], '10,000': [2907], 'events/test': [2908], 'Calibar': [2912], 'flow': [2913], 'cytometer': [2914], '(Becton': [2915], 'Dickinson)': [2916], 'fluorescein': [2919], 'isothiocyanate': [2920], 'filter.': [2921], 'measuring': [2923, 2945], '(MDA).': [2951], 'MDA': [2955], 'spectrophotometric': [2963, 3328], '(37Buege': [2965], 'J.A.': [2966], 'Aust': [2967], 'S.D.': [2968, 4395], 'Methods': [2969, 3406, 3479], '1978;': [2971], '52:': [2972], '302-310Crossref': [2973], '(10824)': [2976], 'Then': [2995], '(500': [2998], 'μl)': [2999], 'mixed': [3001], 'ml': [3004], 'thiobarbituric': [3006, 3011, 3032], 'acid-trichloroacetic': [3007], 'acid-HCl': [3008], '(0.375%': [3010], 'acid,': [3012], 'trichloroacetic': [3013], 'n': [3017], 'HCl,': [3018], '2.0)': [3020], 'heated': [3022, 3246], 'acid-reactive': [3033], 'substance': [3034], '535': [3038], 'mmH2O2': [3052, 3224], '2': [3054, 3086, 3226, 3952, 3985, 4015], 'h,': [3055], 'rinsed': [3056], 'saline,': [3060], '7.3,': [3062], '×g': [3067], 'fixed': [3074], 'immediately': [3075], '2.5%': [3077], 'glutaraldehyde': [3079], 'buffer': [3084, 3426], 'postfixed': [3093], 'osmium': [3096], 'tetroxide': [3097], 'min,': [3100, 3252], 'washed': [3101], 'water,': [3103], 'dehydration': [3109], 'procedure': [3110], 'graded': [3112], 'ethanol': [3113], 'series.': [3114], 'preparing': [3116], 'specimen,': [3118], 'embedded': [3121], 'Epon': [3123], '812': [3124], '(Electron': [3125], 'Microscopy': [3126], 'Sciences,': [3127], 'Fort': [3128], 'Washington,': [3129], 'PA),': [3130], 'random': [3133], 'areas': [3134], 'cut': [3136, 3144], 'processed.': [3138], 'sections': [3140], '(60–70': [3141], 'ultramicrotome': [3147], '(Soya': [3148], 'MT-7000),': [3149], 'copper': [3152], 'grids,': [3153], 'stained': [3155], 'uranyl': [3157], 'acetate': [3158], 'lead': [3160], 'citrate.': [3161], '40': [3164], 'examined': [3170], 'photographed': [3172], 'Hitachi': [3174], 'H-7100': [3175], 'transmission': [3176], 'electron': [3177], '(Hitachi': [3179], 'Japan)': [3181], '75': [3183], 'kV.': [3184], 'luciferin-luciferase': [3192], '(38Spragg': [3193], 'R.G.': [3194], 'Hinshaw': [3195], 'D.B.': [3196], 'Hyslop': [3197], 'P.A.': [3198], 'Schraufstätter': [3199], 'I.U.': [3200], 'Cochrane': [3201], 'C.G.': [3202], 'Clin.': [3204], 'Invest.': [3205], '76:': [3207], '1471-1476Crossref': [3208], '(204)': [3211], 'collected': [3229], 'centrifugation,': [3231], '250': [3234], '(10': [3239], 'KH2PO4,': [3241], 'mmMgSO4,': [3243], '7.4),': [3245], '98': [3248], 'placed': [3254], 'ice.': [3256], 'measurement,': [3259], 'aliquot': [3261], '50-μl': [3264], '(50': [3274], 'NaAsO2,': [3276], 'MgSO4,': [3279], '7.4)': [3281], '800': [3283], 'luciferin/luciferase': [3286], '(Sigma).': [3287, 3448], 'Light': [3288], 'emission': [3289], 'quantified': [3291], 'Turner': [3294], 'Designs': [3295], 'TD': [3296], '20/20': [3297], 'luminometer': [3298], '(Stratec': [3299], 'Biomedical': [3300], 'Systems,': [3301], 'Germany).': [3302], 'all': [3304, 4190], 'experiments,': [3305], 'curves': [3308], 'run': [3310], 'linear': [3313], 'range': [3316], '5–2500': [3318], 'Concentrations': [3320], 'stock': [3323], '259': [3331], 'extinction': [3335], 'coefficient': [3336], '15,400.': [3338], 'values': [3340, 4035], 'Zerez': [3347], '(39Zerez': [3350], 'C.R.': [3351], 'Tanaka': [3354], 'K.R.': [3355], '1987;': [3358], '1964:': [3359], '367-373Crossref': [3360], '(157)': [3362], 'ratio': [3369], 'total': [3374, 3458, 4306, 4317], 'NADP': [3375], '[NADPH]/[NADP+': [3377], '+': [3378], 'NADPH].': [3379], 'level': [3382, 3418, 3451, 3461, 3971], 'producing': [3386], '5-thio-2-nitrobenzoate': [3388], '412': [3390], '(ε=': [3392], '1.36': [3393], '104m−1': [3395], 'cm−1)': [3396], '(40Akerboom': [3402], 'T.P.M.': [3403], '1981;': [3408], '77:': [3409], '373-382Crossref': [3410], '(1464)': [3413], 'potassium': [3424], '(pH': [3427], '7.0)': [3428], 'EDTA,': [3432], '0.2': [3433], 'mg': [3434], '5,5′-dithio-bis(2-nitrobenzoic': [3440], 'acid),': [3441], '0.12': [3443], '2-vinylpyridine': [3468], '3': [3470], 'triethanolamine': [3473], '(41Anderson': [3477], 'M.E.': [3478], '113:': [3482], '548-555Crossref': [3483], '(2421)': [3486], 'isolate': [3490], 'cDNAs': [3491, 4228], 'IDPm,': [3494, 3708, 4085], '(Stratagene)': [3501], 'screened': [3503], '11': [3537, 3783], 'positive': [3538], 'isolated': [3545, 3930], 'about': [3547], 'million': [3549], 'phage': [3550], 'plaques': [3551], 'screened.': [3552], 'From': [3553], 'these': [3554], 'clones,': [3555], 'clone': [3557, 3777], 'insert': [3562], '(1.7': [3563], 'kilobase': [3564, 3823, 3976, 3996], 'pairs)': [3565, 3596, 3824, 3977, 3997], 'purified,': [3567], 'plasmid': [3570], 'pGEM7(+),': [3571], 'its': [3573, 3761, 3787], 'nucleotide': [3574], 'sequence': [3575, 3693, 3714, 3764, 3790], 'determined.': [3577], 'Mouse': [3578], '1,679': [3582], 'base': [3583, 3595], 'pairs': [3584], 'long': [3585, 3753], '(data': [3586, 3967, 4165], 'shown)': [3588], 'open': [3591], 'reading': [3592], 'frame': [3593], '(1,356': [3594], 'entire': [3599], '(Fig.': [3605, 3799, 3951, 3984, 4014], '1).': [3606, 3800], 'Structural': [3607], 'pig': [3611], '(42Haselbeck': [3612], 'R.J.': [3613], 'Colman': [3614], 'R.F.': [3615], 'Biochemistry.': [3618], '31:': [3620], '6219-6223Crossref': [3621], '(45)': [3624], 'bovine,': [3627], 'revealed': [3655], 'precursor': [3658], 'contains': [3662], '452': [3663], '(50,934': [3666], 'Da),': [3667], 'complete': [3670], 'consists': [3672], '413': [3674], '(46,575': [3677], 'Da)': [3678], 'first': [3681], '39': [3682, 4058], 'peptide.': [3689], 'deduced': [3691], 'showed': [3697], '94.5': [3698], '95%': [3700], 'identity': [3701], 'porcine': [3707], 'leader': [3713, 3755], 'quite': [3720], '(mNADP-IDH)': [3728], '(43Yang': [3729], 'Luo': [3731], 'Vinay': [3733], 'Wu': [3735], '1996;': [3740], '60:': [3741], '400-410Crossref': [3742], '(15)': [3745], 'mNADP-IDH': [3749], 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